WO2015096767A1 - 一种全自动即时检验仪 - Google Patents

一种全自动即时检验仪 Download PDF

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Publication number
WO2015096767A1
WO2015096767A1 PCT/CN2014/094931 CN2014094931W WO2015096767A1 WO 2015096767 A1 WO2015096767 A1 WO 2015096767A1 CN 2014094931 W CN2014094931 W CN 2014094931W WO 2015096767 A1 WO2015096767 A1 WO 2015096767A1
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WO
WIPO (PCT)
Prior art keywords
disposed
motor
sample
card
detecting
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Application number
PCT/CN2014/094931
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English (en)
French (fr)
Inventor
周旭一
洪龙斌
徐文杰
陈晓东
周宋兵
沈国金
胡瑞
Original Assignee
杭州中翰盛泰生物技术有限公司
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Application filed by 杭州中翰盛泰生物技术有限公司 filed Critical 杭州中翰盛泰生物技术有限公司
Priority to KR1020167014915A priority Critical patent/KR101836753B1/ko
Priority to CA2931152A priority patent/CA2931152C/en
Priority to US15/101,127 priority patent/US20160299133A1/en
Publication of WO2015096767A1 publication Critical patent/WO2015096767A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
    • G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0427—Sample carriers, cuvettes or reaction vessels nestable or stockable
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G01N2035/0493—Locating samples; identifying different tube sizes

Definitions

  • the invention relates to the technical field of medical testing equipment, in particular to a fully automatic instant tester.
  • the POCT product is a branch of the in vitro diagnostic industry (IVD). It is popular in the clinic for its rapid and easy access to test results. At present, the instant tester has been widely used in hospitals, clinics and patients' homes, and can perform most routine clinical indicators. The global real-time tester market has exceeded $40 billion. In the early 1980s and 1990s, the European and American real-time tester market achieved an average annual growth rate of nearly 30%. With the development of China's economy and the aging of the population, the incidence of rheumatoid arthritis, diabetes, cardiovascular and cerebrovascular diseases has increased year by year, and the instant tester is more and more widely used in clinical practice. With the implementation of China's new medical reform, the popularization of medical insurance, and the improvement of disease prevention and health knowledge, the demand for real-time testers in health care and disease prevention and control will be more in the future, and will play a greater role.
  • a single test has a high average cost.
  • the invention provides a fully automatic instant tester with simple structure, integration and high degree of automation, and supports non-stop loading.
  • a fully automatic instant tester comprising a casing, a frame, a sample holder, a sample input device, a shaker device, a test card stack, a sample reaction device, a test card transport device, a detection device and a control panel, the sample input device, The shaker device, the test card stack, the sample reaction device, the test card transport device and the detection device are all disposed on the frame body, the sample is erected in the sample input device, and the sample test tube is placed on the sample rack.
  • the shaking device is disposed behind the sample input device, and the sample reaction device, the detection card conveying device and the detecting device are all disposed behind the shaking device;
  • the sample input device comprises a push rod mechanism and a limiting mechanism And the sensing mechanism;
  • the shaking device comprises a first bar code machine, a rotating mechanism, a vacuum blood vessel shaking mechanism and a peripheral blood vessel shaking mechanism, wherein the rotating mechanism, the vacuum blood vessel shaking mechanism and the peripheral blood vessel shaking mechanism are fixed at the same In the frame body, the peripheral blood vessel shaking mechanism is disposed under the vacuum blood vessel shaking mechanism, and the rotating mechanism is disposed on the vacuum blood vessel to shake evenly
  • the detection card stack includes a detection card, a detection card holder and a scanning mechanism, the detection card is disposed in the detection card holder, and the scanning mechanism is disposed behind the detection card holder;
  • the sample reaction The device comprises a reaction cup, a water flow ring, a reagent cartridge, a reagent bottle, a loading arm mechanism, a gripping mechanism,
  • the push rod mechanism includes a first push rod, a second push rod, a third push rod and a fourth push rod, and is driven by the first motor, the second motor, the third motor and the fourth motor, respectively, the first a push rod and a third push rod for moving the sample holder in a longitudinal direction, the second push rod and the fourth push rod for moving the sample holder in a lateral direction;
  • the limiting mechanism comprises a pair in the longitudinal direction a first limit switch of the sample rack limit and a second limit switch that limits the sample rack in a lateral direction;
  • the sample input device further includes a limit gate for docking, the limit gate
  • the upper part is provided with a photoelectric contrast sensor.
  • the rotating mechanism includes a first DC motor and a rotating friction head, the first DC motor is slidably coupled to the frame in a vertical direction;
  • the vacuum vessel shaking mechanism includes a guiding block and a grip, the guiding block Fixed on the frame body, the gripper is slidably connected with the frame body in a vertical direction, and the gripper is provided with a stop block, and the block rotates under the guiding action of the guide block, and drives the catch
  • the distal blood vessel shaking mechanism comprises a mounting platform, a second DC motor, a screw rod, a fixing block, a brushless motor and a fixing piece, and the mounting platform is fixed on the frame body, and the fixing block is in the
  • the second DC motor and the lead screw are slidably connected to the mounting platform, and the brushless motor is provided with an eccentric block, and the fixed piece is vibrated when the brushless motor rotates.
  • the reagent cartridge is disposed on the frame body, a fifth motor is disposed inside the reagent chamber, a first gear is disposed at the output end of the fifth motor, and a reagent tray is disposed in the reagent chamber, the reagent tray a ring gear is disposed on the lower surface, the first gear is meshed with the ring gear, and the reagent bottle is disposed on the reagent tray, and the water ring is uniformly provided with four cuvette sockets, and the reaction is performed.
  • a cup is inserted into the reaction cup socket, a water ring is provided with a latching tooth, a sixth motor is arranged outside the water ring, a second gear is arranged at the output end of the sixth motor, and the second gear meshes with the water ring, the metal a bathing area is disposed on a side of the reagent chamber, a reaction cup stacking area is disposed on a side of the metal bathing area, an opening is disposed on the reagent chamber, and the second barcode machine is disposed at the opening
  • the second barcode machine is fixed on the frame body; a heat sink is disposed on one side of the fifth motor in the reagent chamber, a cooling sheet is disposed above the heat sink, and a fan is disposed under the heat sink.
  • the grip mechanism includes a gripping arm, an electromagnet, a slider, a left gripping block, and a right gripping block.
  • the gripping arm is provided with a seventh motor and a sliding rail, and the slider is slidably connected with the sliding rail, and Connected to the seventh motor through a timing belt, the electromagnet is disposed on the slider, the lower end of the electromagnet is provided with a first link, and the left grab block and the right grab block respectively pass through the second link
  • a rod is rotatably coupled to the first link.
  • a reagent compartment cover is disposed above the reagent bottle, and the reagent compartment cover is provided with a fan-shaped notch.
  • the detection module comprises one or several of an immunocolloidal gold detection module, an immunofluorescence detection module, an immunomagnetic bead detection module, and an immunofluorescence microparticle module, and the immunocolloidal gold detection module or the immunofluorescence detection module or the immunomagnetic bead detection
  • a module or immunofluorescent particle module is disposed above the test card holder.
  • the automatic instant tester integrates two technical categories of immunocolloidal gold technology and immunofluorescence technology on one instrument, and provides a fully automatic, multi-project automatic fast immunoassay analyzer with integrated , automation, support for non-stop loading and other advantages.
  • the application of sample loading, detection, data processing, and results reporting in one go has not only made up for the shortcomings of manual operation and slow speed of small POCT projects, but also overcomes the trouble of long-term TAT and pre-processing of large-scale automated instruments.
  • POCT enables automated batch inspection to make quality control more practical.
  • the fully automatic real-time tester overcomes the shortcomings of large-scale automated instrument pre-processing and many process steps. At the same time, automatic continuous detection is realized, which greatly shortens the average detection cycle of each test, and can solve the single manual operation time-consuming and cannot be batch-detected. The problem.
  • This fully automatic real-time tester can meet single or multi-project, single or batch sample test in hospital outpatients.
  • Fig. 1 is a structural schematic view showing the state of the outer casing of the automatic instant checker according to the present invention.
  • FIG. 2 is a schematic structural view of a sample input device according to the present invention.
  • FIG. 3 is a schematic structural view of the shaker device of the present invention.
  • Figure 4 is a schematic view showing the structure of the sample reaction device of the present invention.
  • Figure 5 is an exploded view of the reagent cartridge of the present invention.
  • Figure 6 is a schematic view showing the structure of the grip mechanism of the present invention.
  • FIG. 1, FIG. 2, FIG. 3, FIG. 4, FIG. 5 and FIG. 6, including a casing (not shown), a frame body 1, and a sample Rack 2, sample input device, shaker device, test card stack, sample reaction device, test card transport device, detection device and control panel (not shown), sample input device, shake device, test card stack
  • the sample reaction device, the test card transport device and the detection device are all disposed on the frame body, the sample is erected in the sample input device, and the sample test tube 3 is placed on the sample rack 2, and the shaker device is placed Provided behind the sample input device, the sample reaction device, the detection card conveying device and the detecting device are all disposed behind the shaking device;
  • the sample input device comprises a push rod mechanism, a limiting mechanism and a sensing mechanism;
  • the shaking device comprises a first bar code machine 4, a rotating mechanism, a vacuum blood vessel shaking mechanism and a peripheral blood vessel shaking mechanism, wherein the rotating mechanism, the vacuum blood vessel shaking mechanism and the peripheral blood
  • the tip blood vessel shaking mechanism is disposed under the vacuum blood vessel shaking mechanism, the rotation mechanism is disposed on one side of the vacuum blood vessel shaking mechanism;
  • the detection card stack comprises a detection card 5, a detection card holder 6 and a scanning mechanism,
  • the detection card 5 is disposed in the detection card holder 6.
  • the scanning mechanism is disposed behind the detection card holder 6.
  • the sample reaction device includes a reaction cup 7, a water circulation ring 8, a reagent chamber 9, and a reagent bottle 10.
  • the reagent bottle 10 is disposed in the reagent chamber 9, and the water flowing ring 8 is disposed on the upper end surface of the reagent chamber 9,
  • the reaction cup 7 is disposed on the water flow ring 8
  • the loading arm mechanism is disposed above the reagent chamber 9 and fixed on the frame body 1
  • the grip mechanism is disposed in the reaction cup stack area 11 and above the metal bathing area 12, and fixed to the frame body 1
  • the detecting card conveying device comprises a detecting card conveying arm, a buffering bin 13 and a card taking mechanism, and the detecting card is transported
  • An arm is disposed behind the stack of the detecting card and fixed on the frame body 1.
  • the card taking mechanism is slidably disposed on the detecting card transport arm;
  • the detecting device includes a detecting mechanism and a detecting card mechanism.
  • the detecting mechanism is disposed above the discarding detection card mechanism, and the buffer chamber is disposed between the detecting mechanism and the card taking mechanism;
  • the control board is fixed on the frame body 1, the push rod mechanism, the limit Position mechanism, induction mechanism, first bar code machine, rotating mechanism, vacuum blood vessel shaking mechanism, peripheral blood vessel shaking mechanism, scanning mechanism, loading arm mechanism, gripping mechanism, metal bath area, detection card transport arm, buffer chamber,
  • the card taking mechanism, the detecting mechanism and the discarding card mechanism are respectively electrically connected to the control board.
  • the push rod mechanism includes a first push rod 14, a second push rod 15, a third push rod 16 and a fourth push rod 17, and respectively pass the first motor, the second motor, the third motor and Driven by the fourth motor, the first push rod 14 and the third push rod 16 are used to move the sample holder 2 in the longitudinal direction, and the second push rod 15 and the fourth push rod 17 are used to move in the lateral direction.
  • the limiting mechanism includes a first limit switch 18 that limits the sample holder in a longitudinal direction and a second limit switch 19 that limits the sample holder in a lateral direction;
  • the sample The input device further includes a limit gate 20 for docking, and the upper portion of the limit gate 20 is provided with a photoelectric countermeasure sensor 21.
  • the rotating mechanism includes a first DC motor 22 and a rotating friction head 23, and the first DC motor 22 is slidably connected to the frame body 1 in a vertical direction;
  • the vacuum blood vessel shaking mechanism includes a guiding The block 24 and the gripper 25 are fixed to the frame body 1.
  • the gripper 25 is slidably coupled to the frame body 1 in a vertical direction, and the gripper 25 is provided with a stopper 26
  • the stopper 26 rotates under the guiding action of the guiding block 24 and drives the gripper 25 to rotate
  • the peripheral blood vessel shaking mechanism comprises a mounting platform 27, a second DC motor 28, a screw rod 29, a fixing block 30, and no a brush motor 31 and a fixing piece 32
  • the mounting platform 27 is fixed on the frame body 1
  • the fixing block 30 is slidably connected to the mounting platform 27 by the second DC motor 28 and the screw rod.
  • the brushless motor 31 is provided with an eccentric block 33, and the fixed piece 32 is vibrated when the brushless motor 31 rotates.
  • the reagent cartridge 9 is disposed on the frame body 1 , and the fifth motor 34 is disposed inside the reagent chamber 9 , and the first gear 35 is disposed at the output end of the fifth motor 34 .
  • a reagent tray 36 is disposed in the cartridge 9, and a lower surface of the reagent tray 36 is provided with a ring gear 37.
  • the first gear 35 meshes with the ring gear 37, and the reagent bottle 10 is disposed on the reagent tray 36.
  • the water ring 8 is provided with four cuvette sockets 38, and the cuvette 7 is inserted into the cuvette socket 38.
  • the water ring is provided with a latching tooth 39, and the water ring 8 is disposed outside.
  • the output end of the sixth motor 40 is provided with a second gear 41.
  • the second gear 41 meshes with the water ring 8.
  • the metal bath zone 12 is disposed in the reagent compartment 9.
  • the cuvette stacking area 11 is disposed on one side of the metal bathing zone 12, the reagent compartment 9 is provided with an opening 42, and the opening 42 is provided with the second barcode machine 43
  • the second code machine 43 is fixed on the frame body 1; a heat sink 44 is disposed on the side of the fifth motor 34 in the reagent chamber 9, and a cooling plate 45 is disposed above the heat sink 44. Said heat sink 44 is provided below the fan 46.
  • the grip mechanism includes a gripping arm 47, an electromagnet 48, a slider 49, a left gripping block 50, and a right gripping block 51.
  • the gripping arm 47 is provided with a seventh motor 52 and a slide rail 53,
  • the slider 49 is slidably connected to the slide rail 53 and connected to the seventh motor 52 through a timing belt 54.
  • the electromagnet 48 is disposed on the slider 49, and the lower end of the electromagnet 48 is disposed.
  • There is a first link 55, and the left grab block 50 and the right grab block 51 are rotatably coupled to the first link 55 via a second link 56, respectively.
  • a reagent compartment cover 57 is disposed above the reagent bottle 10, and the reagent compartment cover 57 is provided with a fan-shaped notch 58.
  • the detecting mechanism includes an immunocolloidal gold detecting module (not shown) and an immunofluorescence detecting module (not shown), and the immunocolloidal gold detecting module and the immunofluorescence detecting module are both It is arranged above the detection card 5.
  • the detection mechanism may also include one or two immunocolloidal gold detection modules, or may also include one or two immunofluorescence detection modules, or may also include one or two exemptions.
  • the plaque magnetic bead detection module may also include one or two immunofluorescent particle modules, or may also include an immunocolloidal gold detection module, an immunofluorescence detection module, and an immunomagnetic bead detection module, or may also include an immunocolloidal gold detection.
  • the module, an immunofluorescence detection module, an immunomagnetic bead detection module, and an immunofluorescent particle module Then, it is also within the protection scope of the present invention, and details are not described herein again.

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Abstract

一种全自动即时检验仪，包括外壳、架体（1）、样本架（2）、样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置、检测装置和控制板；样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置和检测装置均设于架体（1）上；样本架（2）设于样本输入装置内，样本架（2）上放置有样本试管（3）；摇匀装置设于样本输入装置后方；样本反应装置、检测卡输送装置和检测装置均设于摇匀装置后方。该全自动即时检验仪结构简单、集成化和自动化程度高、支持不停机加载。

Description

一种全自动即时检验仪 技术领域
本发明涉及医疗检验设备技术领域，具体地说是一种全自动即时检验仪。
背景技术
POCT产品是体外诊断行业(IVD)的一个分支，它凭借便捷、快速的优势,实现在患者身边快速取得检验结果而深受临床的欢迎。目前即时检验仪已被广泛应用在医院、诊所及患者家中，能够进行绝大多数常规临床指标的检测。全球即时检验仪市场规模已超过400亿美元。在行业发展初期的1980至1990年代，欧美即时检验仪市场实现了近30％的年均增速。随着中国经济的发展和人口老龄化趋势日益严重，风湿性关节炎、糖尿病、心脑血管类疾病发病率逐年增长，即时检验仪在临床也越来越广泛应用。随着中国新医改的实施、医保的普及、防病健康知识的提高，今后即时检验仪在健康保健、疾病预防监控中的需求量会更多，将会发挥更大的作用。
医学科学的进步在很大程度上有赖于相关实验室检查。目前市场上拥有很多自动化设备，其自动化程度高、检测容量大，但是需要较复杂的标本前处理流程和较长的检测周期(TAT)。而现有的即时检验仪可做到微型、即时、简便的床旁检测要求，但即时检验仪的共同特点都是单个检测，如果临床有较多的批量标本，或者急诊检测同一个项目的标本数量较多，则单个检测的即时检验仪小仪器就很难满足其要求。单个操作个体差异大，结果离散程度高，质量控制难，不利于同一医疗机构内检验结果一致化；而且手工操作费力、费时速度慢，拉长了平均单个检测的检测周期(TAT)，且分散单个检测，平均成本高。
发明内容
本发明提供一种结构简单、集成化和自动化程度高、支持不停机加载的全自动即时检验仪。
本发明是通过下述技术方案实现的：
一种全自动即时检验仪，包括外壳、架体、样本架、样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置、检测装置和控制板，所述样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置和检测装置均设于所述架体上，所述样本架设于所述样本输入装置内，所述样本架上放置有样本试管，所述摇匀装置设于所述样本输入装置后方，所述样本反应装置、检测卡输送装置和检测装置均设于所述摇匀装置后方；所述样本输入装置包括推杆机构、限位机构和感应机构；所述摇匀装置包括第一条码机、旋转机构、真空血管摇匀机构和末梢血管摇匀机构，所述旋转机构、真空血管摇匀机构和末梢血管摇匀机构均固定于所述架体上，所述末梢血管摇匀机构设于所述真空血管摇匀机构下方，所述旋转机构设于所述真空血管摇匀机构一侧；所述检测卡堆栈包括检测卡、检测卡架和扫描机构，所述检测卡设于所述检测卡架内，所述扫描机构设于所述检测卡架后方；所述样本反应装置包括反应杯、流水环、试剂仓、试剂瓶、加样臂机构、抓手机构、反应杯堆栈区和金属浴区，所述试剂瓶设于试剂仓内，所述流水环设于所述试剂仓上端面，所述反应杯设于所述流水环上，所述加样臂机构设于所述试剂仓上方，并固定于所述架体上，所述抓手机构设于所述反应杯堆栈区和金属浴区上方，并固定于所述架体上；所述检测卡输送装置包括检测卡输送臂、缓冲仓和取卡机构，所述检测卡输送臂设于所述检测卡堆栈后方，并固定于所述架体上，所述取卡机构滑动设于所述检测卡输送臂上；所述检测装置包括检测机构和丢检测卡机构，所述检测机 构设于所述丢检测卡机构上方，所述缓冲仓设于所述检测机构和取卡机构之间；所述控制板固定于所述架体上，所述推杆机构、限位机构、感应机构、第一条码机、旋转机构、真空血管摇匀机构、末梢血管摇匀机构、扫描机构、加样臂机构、抓手机构、金属浴区、检测卡输送臂、缓冲仓、取卡机构、检测机构和丢检测卡机构分别于所述控制板电连接。
所述推杆机构包括第一推杆、第二推杆、第三推杆和第四推杆，并分别通过第一电机、第二电机、第三电机和第四电机带动，所述第一推杆和第三推杆用于在纵向上移动所述样本架，所述第二推杆和第四推杆用于在横向上移动所述样本架；所述限位机构包括在纵向上对所述样本架限位的第一限位开关和在横向上对所述样本架限位的第二限位开关；所述样本输入装置还包括用于对接的限位门，所述限位门上部设有光电对射感应器。
所述旋转机构包括第一直流电机和旋转摩擦头，所述第一直流电机与所述架体在垂直方向上滑动连接；所述真空血管摇匀机构包括导向块和抓手，所述导向块固定于所述架体上，所述抓手与所述架体在垂直方向上滑动连接，所述抓手上设有挡块，所述挡块在导向块的导向作用下转动，并带动抓手转动；所述末梢血管摇匀机构包括安装平台、第二直流电机、丝杆、固定块、无刷电机和固定片，所述安装平台固定于所述架体上，所述固定块在所述第二直流电机和丝杆的带动下与所述安装平台滑动连接，所述无刷电机上设有偏心块，在所述无刷电机转动时带动所述固定片振动。
所述试剂仓设于所述架体上，所述试剂仓内部设有第五电机，所述第五电机输出端设有第一齿轮，所述试剂仓内设有试剂托盘，所述试剂托盘下表面上设有齿环，所述第一齿轮与所述齿环相啮合，所述试剂瓶设于所述试剂托盘上，所述流水环上均布有四个反应杯插口，所述反应杯插入所述反应杯插口内，所 述流水环上设有卡齿，所述流水环外侧设有第六电机，所述第六电机输出端上设有第二齿轮，所述第二齿轮与所述流水环相啮合，所述金属浴区设于所述试剂仓一侧，所述反应杯堆栈区设于所述金属浴区一侧，所述试剂仓上设有开口，所述开口处设有所述第二条码机，所述第二条码机固定于所述架体上；所述试剂仓内位于所述第五电机一侧设有散热器，所述散热器上方设有制冷片，所述散热器下方设有风机。
所述抓手机构包括抓手臂、电磁铁、滑块、左抓块和右抓块，所述抓手臂上设有第七电机和滑轨，所述滑块与所述滑轨滑动连接，并通过同步带与所述第七电机相连接，所述电磁铁设于所述滑块上，所述电磁铁下端设有第一连杆，所述左抓块和右抓块分别通过第二连杆与所述第一连杆转动连接。
所述试剂瓶上方设有试剂仓盖，所述试剂仓盖上设有扇形缺口。
所述检测模块包括免疫胶体金检测模块、免疫荧光检测模块、免疫磁珠检测模块、免疫荧光微粒模块中的一个或者几个，所述免疫胶体金检测模块或者免疫荧光检测模块或者免疫磁珠检测模块或者免疫荧光微粒模块设于所述检测卡托架上方。
本发明所带来的有益效果是：
本发明中，所述全自动即时检验仪将二大技术门类免疫胶体金技术和免疫荧光技术整合在一台仪器上，提供一款全自动、多项目的全自动快速免疫分析仪，具有集成化、自动化、支持不停机加载等优点。使加样、检测、数据处理、结果报告“一气呵成”，既弥补了小型POCT项目手工操作繁琐、速度慢的缺点，又克服大型自动化仪器检测需较长的TAT和标本前处理的麻烦。POCT实现自动化批量检测后使质量控制变得更切实可行。而且我们针对国内医院病人多，工作量大，对成本要求低的特点，开发的仪器、试剂远低于同类进口产品，更 适合中国国情。该全自动即时检验仪克服了大型自动化仪器标本前处理繁琐，流程环节多的缺点，同时，实现自动连续检测，大大缩短平均每个测试的检测周期，又能解决单个手工操作费时，不能批量检测的问题。本全自动即时检验仪可满足医院门诊单项目或多项目，单个或批量样本检测。
附图说明
以下结合附图对本发明作进一步详细说明。
图1为本发明所述全自动即时检验仪去掉外壳状态的结构示意图。
图2为本发明所述样本输入装置的结构示意图。
图3为本发明所述摇匀装置的结构示意图。
图4为本发明所述样本反应装置的结构示意图。
图5为本发明所述试剂仓的爆炸图。
图6为本发明所述抓手机构的结构示意图。
图中部件名称对应的标号如下：
1、架体；2、样本架；3、样本试管；4、第一条码机；5、检测卡；6、检测卡架；7、反应杯；8、流水环；9、试剂仓；10、试剂瓶；11、反应杯堆栈区；12、金属浴区；13、缓冲仓；14、第一推杆；141、第一电机；15、第二推杆；151、第二电机；16、第三推杆；161、第三电机；17、第四推杆；171、第四电机；18、第一限位开关；19、第二限位开关；20、限位门；21、光电对射感应器；22、第一直流电机；23、旋转摩擦头；24、导向块；25、抓手；26、挡块；27、安装平台；28、第二直流电机；29、丝杆；30、固定块；31、无刷电机；32、固定片；33、偏心块；34、第五电机；35、第一齿轮；36、试剂托盘；37、齿环；38、反应杯插口；39、卡齿；40、第六电机；41、第二齿轮；42、开口；43、第二条码机；44、散热器；45、制冷片；46、风机；47、抓手臂；48、电 磁铁；49、滑块；50、左抓块；51、右抓块；52、第七电机；53、滑轨；54、同步带；55、第一连杆；56、第二连杆；57、试剂仓盖；58、扇形缺口。
具体实施方式
下面结合附图及实施例对本发明作进一步的详述：
作为本发明所述全自动即时检验仪的实施例，如图1、图2、图3、图4、图5和图6所示，包括外壳(图中未示出)、架体1、样本架2、样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置、检测装置和控制板(图中未示出)，所述样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置和检测装置均设于所述架体上，所述样本架设于所述样本输入装置内，所述样本架2上放置有样本试管3，所述摇匀装置设于所述样本输入装置后方，所述样本反应装置、检测卡输送装置和检测装置均设于所述摇匀装置后方；所述样本输入装置包括推杆机构、限位机构和感应机构；所述摇匀装置包括第一条码机4、旋转机构、真空血管摇匀机构和末梢血管摇匀机构，所述旋转机构、真空血管摇匀机构和末梢血管摇匀机构均固定于所述架体上，所述末梢血管摇匀机构设于所述真空血管摇匀机构下方，所述旋转机构设于所述真空血管摇匀机构一侧；所述检测卡堆栈包括检测卡5、检测卡架6和扫描机构，所述检测卡5设于所述检测卡架6内，所述扫描机构设于所述检测卡架6后方；所述样本反应装置包括反应杯7、流水环8、试剂仓9、试剂瓶10、加样臂机构、抓手机构、反应杯堆栈区11和金属浴区12，所述试剂瓶10设于试剂仓9内，所述流水环8设于所述试剂仓9上端面，所述反应杯7设于所述流水环8上，所述加样臂机构设于所述试剂仓9上方，并固定于所述架体1上，所述抓手机构设于所述反应杯堆栈区11和金属浴区12上方，并固定于所述架体1上；所述检测卡输送装置包括检测卡输送臂、缓冲仓13和取卡机构，所述检测卡输送 臂设于所述检测卡堆栈后方，并固定于所述架体1上，所述取卡机构滑动设于所述检测卡输送臂上；所述检测装置包括检测机构和丢检测卡机构，所述检测机构设于所述丢检测卡机构上方，所述缓冲仓设于所述检测机构和取卡机构之间；所述控制板固定于所述架体1上，所述推杆机构、限位机构、感应机构、第一条码机、旋转机构、真空血管摇匀机构、末梢血管摇匀机构、扫描机构、加样臂机构、抓手机构、金属浴区、检测卡输送臂、缓冲仓、取卡机构、检测机构和丢检测卡机构分别于所述控制板电连接。
本实施例中，所述推杆机构包括第一推杆14、第二推杆15、第三推杆16和第四推杆17，并分别通过第一电机、第二电机、第三电机和第四电机带动，所述第一推杆14和第三推杆16用于在纵向上移动所述样本架2，所述第二推杆15和第四推杆17用于在横向上移动所述样本架2；所述限位机构包括在纵向上对所述样本架限位的第一限位开关18和在横向上对所述样本架限位的第二限位开关19；所述样本输入装置还包括用于对接的限位门20，所述限位门20上部设有光电对射感应器21。
本实施例中，所述旋转机构包括第一直流电机22和旋转摩擦头23，所述第一直流电机22与所述架体1在垂直方向上滑动连接；所述真空血管摇匀机构包括导向块24和抓手25，所述导向块24固定于所述架体1上，所述抓手25与所述架体1在垂直方向上滑动连接，所述抓手25上设有挡块26，所述挡块26在导向块24的导向作用下转动，并带动抓手25转动；所述末梢血管摇匀机构包括安装平台27、第二直流电机28、丝杆29、固定块30、无刷电机31和固定片32，所述安装平台27固定于所述架体1上，所述固定块30在所述第二直流电机28和丝杆的带动下与所述安装平台27滑动连接，所述无刷电机31上设有偏心块33，在所述无刷电机31转动时带动所述固定片32振动。
本实施例中，所述试剂仓9设于所述架体1上，所述试剂仓9内部设有第五电机34，所述第五电机34输出端设有第一齿轮35，所述试剂仓9内设有试剂托盘36，所述试剂托盘36下表面上设有齿环37，所述第一齿轮35与所述齿环37相啮合，所述试剂瓶10设于所述试剂托盘36上，所述流水环8上均布有四个反应杯插口38，所述反应杯7插入所述反应杯插口38内，所述流水环上设有卡齿39，所述流水环8外侧设有第六电机40，所述第六电机40输出端上设有第二齿轮41，所述第二齿轮41与所述流水环8相啮合，所述金属浴区12设于所述试剂仓9一侧，所述反应杯堆栈区11设于所述金属浴区12一侧，所述试剂仓9上设有开口42，所述开口42处设有所述第二条码机43，所述第二条码机43固定于所述架体1上；所述试剂仓9内位于所述第五电机34一侧设有散热器44，所述散热器44上方设有制冷片45，所述散热器44下方设有风机46。
本实施例中，所述抓手机构包括抓手臂47、电磁铁48、滑块49、左抓块50和右抓块51，所述抓手臂47上设有第七电机52和滑轨53，所述滑块49与所述滑轨53滑动连接，并通过同步带54与所述第七电机52相连接，所述电磁铁48设于所述滑块49上，所述电磁铁48下端设有第一连杆55，所述左抓块50和右抓块51分别通过第二连杆56与所述第一连杆55转动连接。
本实施例中，所述试剂瓶10上方设有试剂仓盖57，所述试剂仓盖57上设有扇形缺口58。
本实施例中，所述检测机构包括一个免疫胶体金检测模块(图中未示出)和一个免疫荧光检测模块(图中未示出)，所述免疫胶体金检测模块和免疫荧光检测模块均设于所述检测卡5上方。
当然，所述检测机构也可以包括一个或者两个免疫胶体金检测模块，或者也可以包括一个或者两个免疫荧光检测模块，或者也可以包括一个或者两个免 疫磁珠检测模块也可以包括一个或者两个免疫荧光微粒模块，或者也可以包括一个免疫胶体金检测模块、一个免疫荧光检测模块和一个免疫磁珠检测模块，或者也可以包括一个免疫胶体金检测模块、一个免疫荧光检测模块、一个免疫磁珠检测模块和免疫荧光微粒模块。那么，也都在本发明保护范围之内，这里不再一一赘述。

Claims (7)

  1. 一种全自动即时检验仪，其特征在于包括外壳、架体、样本架、样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置、检测装置和控制板，所述样本输入装置、摇匀装置、检测卡堆栈、样本反应装置、检测卡输送装置和检测装置均设于所述架体上，所述样本架设于所述样本输入装置内，所述样本架上放置有样本试管，所述摇匀装置设于所述样本输入装置后方，所述样本反应装置、检测卡输送装置和检测装置均设于所述摇匀装置后方；所述样本输入装置包括推杆机构、限位机构和感应机构；所述摇匀装置包括第一条码机、旋转机构、真空血管摇匀机构和末梢血管摇匀机构，所述旋转机构、真空血管摇匀机构和末梢血管摇匀机构均固定于所述架体上，所述末梢血管摇匀机构设于所述真空血管摇匀机构下方，所述旋转机构设于所述真空血管摇匀机构一侧；所述检测卡堆栈包括检测卡、检测卡架和扫描机构，所述检测卡设于所述检测卡架内，所述扫描机构设于所述检测卡架后方；所述样本反应装置包括反应杯、流水环、试剂仓、试剂瓶、加样臂机构、抓手机构、反应杯堆栈区和金属浴区，所述试剂瓶设于试剂仓内，所述流水环设于所述试剂仓上端面，所述反应杯设于所述流水环上，所述加样臂机构设于所述试剂仓上方，并固定于所述架体上，所述抓手机构设于所述反应杯堆栈区和金属浴区上方，并固定于所述架体上；所述检测卡输送装置包括检测卡输送臂、缓冲仓和取卡机构，所述检测卡输送臂设于所述检测卡堆栈后方，并固定于所述架体上，所述取卡机构滑动设于所述检测卡输送臂上；所述检测装置包括检测机构和丢检测卡机构，所述检测机构设于所述丢检测卡机构上方，所述缓冲仓设于所述检测机构和取卡机构之间；所述控制板固定于所述架体上，所述推杆机构、限位机构、 感应机构、第一条码机、旋转机构、真空血管摇匀机构、末梢血管摇匀机构、扫描机构、加样臂机构、抓手机构、金属浴区、检测卡输送臂、缓冲仓、取卡机构、检测机构和丢检测卡机构分别于所述控制板电连接。
  2. 如权利要求1所述的全自动即时检验仪，其特征在于所述推杆机构包括第一推杆、第二推杆、第三推杆和第四推杆，并分别通过第一电机、第二电机、第三电机和第四电机带动，所述第一推杆和第三推杆用于在纵向上移动所述样本架，所述第二推杆和第四推杆用于在横向上移动所述样本架；所述限位机构包括在纵向上对所述样本架限位的第一限位开关和在横向上对所述样本架限位的第二限位开关；所述样本输入装置还包括用于对接的限位门，所述限位门上部设有光电对射感应器。
  3. 如权利要求2所述的全自动即时检验仪，其特征在于所述旋转机构包括第一直流电机和旋转摩擦头，所述第一直流电机与所述架体在垂直方向上滑动连接；所述真空血管摇匀机构包括导向块和抓手，所述导向块固定于所述架体上，所述抓手与所述架体在垂直方向上滑动连接，所述抓手上设有挡块，所述挡块在导向块的导向作用下转动，并带动抓手转动；所述末梢血管摇匀机构包括安装平台、第二直流电机、丝杆、固定块、无刷电机和固定片，所述安装平台固定于所述架体上，所述固定块在所述第二直流电机和丝杆的带动下与所述安装平台滑动连接，所述无刷电机上设有偏心块，在所述无刷电机转动时带动所述固定片振动。
  4. 如权利要求3所述的全自动即时检验仪，其特征在于所述试剂仓设于所述架体上，所述试剂仓内部设有第五电机，所述第五电机输出端设有第一齿轮，所述试剂仓内设有试剂托盘，所述试剂托盘下表面上设有齿环，所述第一齿轮与所述齿环相啮合，所述试剂瓶设于所述试剂托盘上，所述流水环上均布有四 个反应杯插口，所述反应杯插入所述反应杯插口内，所述流水环上设有卡齿，所述流水环外侧设有第六电机，所述第六电机输出端上设有第二齿轮，所述第二齿轮与所述流水环相啮合，所述金属浴区设于所述试剂仓一侧，所述反应杯堆栈区设于所述金属浴区一侧，所述试剂仓上设有开口，所述开口处设有所述第二条码机，所述第二条码机固定于所述架体上；所述试剂仓内位于所述第五电机一侧设有散热器，所述散热器上方设有制冷片，所述散热器下方设有风机。
  5. 如权利要求4所述的全自动即时检验仪，其特征在于所述抓手机构包括抓手臂、电磁铁、滑块、左抓块和右抓块，所述抓手臂上设有第七电机和滑轨，所述滑块与所述滑轨滑动连接，并通过同步带与所述第七电机相连接，所述电磁铁设于所述滑块上，所述电磁铁下端设有第一连杆，所述左抓块和右抓块分别通过第二连杆与所述第一连杆转动连接。
  6. 如权利要求5所述的全自动即时检验仪，其特征在于所述试剂瓶上方设有试剂仓盖，所述试剂仓盖上设有扇形缺口。
  7. 如权利要求6所述的全自动即时检验仪，其特征在于所述检测模块包括免疫胶体金检测模块、免疫荧光检测模块、免疫磁珠检测模块、免疫荧光微粒模块中的一个或者几个，所述免疫胶体金检测模块或者免疫荧光检测模块或者免疫磁珠检测模块或者免疫荧光微粒模块设于所述检测卡托架上方。
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