WO2015092888A1 - Dispositif d'administration de médicament par voie orale - Google Patents

Dispositif d'administration de médicament par voie orale Download PDF

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Publication number
WO2015092888A1
WO2015092888A1 PCT/JP2013/083958 JP2013083958W WO2015092888A1 WO 2015092888 A1 WO2015092888 A1 WO 2015092888A1 JP 2013083958 W JP2013083958 W JP 2013083958W WO 2015092888 A1 WO2015092888 A1 WO 2015092888A1
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WO
WIPO (PCT)
Prior art keywords
oral administration
viscous medium
drug
joint
administration device
Prior art date
Application number
PCT/JP2013/083958
Other languages
English (en)
Japanese (ja)
Inventor
修司 盛本
大帆 三上
山内　浩
Original Assignee
株式会社モリモト医薬
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社モリモト医薬 filed Critical 株式会社モリモト医薬
Priority to PCT/JP2013/083958 priority Critical patent/WO2015092888A1/fr
Priority to JP2015553279A priority patent/JP6168160B2/ja
Priority to TW103138906A priority patent/TWI662959B/zh
Publication of WO2015092888A1 publication Critical patent/WO2015092888A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0046—Cups, bottles or bags

Definitions

  • the present invention relates to a drug oral administration device for orally administering drugs, and particularly to a device for forming a drug-coated medium in which a plurality of coated drugs are integrated after coating individual drugs.
  • the container 11 of the viscous drug product 10 is a container in which the surface and the back of a pair of sheets made of, for example, polypropylene or polyethylene are bonded together, and a sealed space 12 is formed between the pair of sheets.
  • the structure of the container 11 is not restricted to said thing, What is necessary is just to have the space sealed in the inside.
  • the sealed space of the container 11 is divided into a liquid compartment 12a and a medicine compartment 12b by a separator 13.
  • a separator 13 For example, when the pressure in the liquid separating section 12a increases, the separating section 13 is formed so that the liquid compartment 12a and the medicine compartment 12b communicate with each other.
  • liquid 5 such as purified water such as purified water, tea, and juice is stored.
  • the above-described viscous drug preparation 1 of the present invention is accommodated in the medicine compartment 12b.
  • the aforementioned viscous product preparation 10 has the following points to be improved.
  • the liquid 5 contained in the liquid compartment 12a and the viscous drug substance preparation 1 contained in the medicine compartment 12b are separated when the container 11 is squeezed by hand. Mix together. That is, the isolation part 13 is formed so as to be in close contact with a force that can be gripped with a hand.
  • the present invention provides a drug coating in which a drug and a viscous medium are separately stored and portable, and each drug is coated and integrated with a plurality of drugs when orally administered. It is an object of the present invention to provide an oral drug administration device that can easily form a medium and can be administered orally.
  • a drug oral administration device is formed of a predetermined forming material having a planar shape, and has an open end portion having an opening and a closed closed end portion, which are positioned to face the open end portion.
  • a device for oral administration of medicines having a cylindrical shape, which is a viscous medium for coating medicines and medicines containing supplements for replenishing predetermined nutrients.
  • Viscous medium that forms a drug-coated medium integrated with the same, formed so as to connect the first side and the second side formed when the cylindrical planar shape is formed, and located opposite to each other A space formed by the intermediate joint, the intermediate joint, the side, and the closed end for joining the forming material, the viscous medium enclosure for enclosing the viscous medium, from the open end To descend toward the closed end,
  • the discharge port forming inclined joint portion that is formed so as to connect the first side portion from a predetermined end position between the first side portion and the second side portion, and joins the forming materials positioned opposite to each other.
  • the said edge part position has the discharge port formation inclination junction part formed in the said open end part side rather than the said intermediate junction part.
  • the viscous medium is cut to an appropriate size by moving the viscous medium along the discharge port forming inclined joint, and the cut viscous medium is formed between the second side portion and the end position. Can be discharged from the outlet. Therefore, a drug-coated medium in which drugs and a viscous medium are uniformly integrated can be easily formed.
  • the second side portion is an inclined side portion that rises from the open end portion toward the closed end portion, at a position facing the discharge port forming inclined joint portion.
  • An inclined side portion formed.
  • the viscous medium can move the viscous medium along the discharge port forming inclined joint portion and the inclined side portion, the viscous medium cut to an appropriate size can be formed more easily.
  • the discharge port forming inclined joint portion does not have a constant inclination angle.
  • the discharge port forming inclined joint is formed by a continuous curve.
  • the discharge port forming inclined joint portion has an arc shape.
  • a support joint that joins the forming material that is formed so as to connect the discharge port forming inclined joint and the first side portion, and facing each other, A support joint formed on the open end side of the intermediate joint.
  • the open end portion has a notch that exposes the other forming material in any one of the forming materials facing each other. To do.
  • the drugs can be easily put into the drug oral administration device.
  • the drug-coated medium when the drug-coated medium is orally administered, the drug-coated medium can be easily orally administered because the drug-coated medium can be disposed on the exposed molding material.
  • the oral drug administration device includes a storage state maintaining unit that maintains a storage state in which the open end is folded at least once toward the closed end.
  • the storage state maintaining part is a cut formed in the closed end part.
  • the storage state maintaining unit is formed continuously from the closed end on the side opposite to the viscous medium enclosing unit, and an end different from the closed end side is provided.
  • An opening is provided to store an end portion different from the closed end portion in the storage state.
  • the storage state maintaining part is formed on the first side part and / or the second side part, and is formed on the open end part side with respect to the intermediate joint part. And a notch formed on the closed end side with respect to the intermediate joint portion is engaged with each other.
  • the oral drug administration device has the predetermined drugs.
  • FIG. 1 is a front view of an oral drug administration device 100 that is an embodiment of an oral drug administration device according to the present invention. It is a rear view of the chemical
  • FIG. It is a figure which shows the usage method of the chemical
  • FIG. It is a figure which shows the usage method of the chemical
  • FIG. It is a figure which shows the usage method of the chemical
  • FIG. 1 shows a front view of the drug oral administration device 100
  • FIG. 2 shows a rear view of the drug oral administration device 100.
  • the oral drug administration device 100 is formed by using, as a forming material, a planar sheet formed of a material that is fused by heat, such as polypropylene or polyethylene.
  • the oral medicine administration device 100 includes a joint side portion 101, a bent side portion 102, a closed end portion 103, an open end portion 104, an intermediate joint portion 105, a discharge port forming joint portion 106, and a storage state maintenance. Part 107 is provided.
  • the oral drug administration device 100 forms a cylindrical shape by fusing the opposite ends of one sheet with heat to form the side joining region 101r.
  • the joining side portion 101 has one end portion 104T1 of the open end portion 104 and one end portion 103T1 of the corresponding closed end portion 103 at the boundary of the side joining region 101r on the side of the bent side portion 102 (described later). It is formed by tying.
  • the joining side portion 101 has an inclined side portion 101a.
  • the inclined side portion 101a is formed so as to increase in the direction from the open end portion 104 side toward the closed end portion 103 side.
  • the inclined side portion 101a is formed at a position facing the discharge port forming joint portion 106, particularly the second inclined joint portion 106b (described later).
  • the bonding side portion 101 that is a boundary on the side of the bent side portion 102 (described later) and the outer side portion 101e that is the boundary on the opposite side of the bonding side portion 101 are formed in parallel. Yes.
  • the folding side portion 102 is positioned to face the side portion where the joining side portion 101 is formed.
  • the folding side portion 102 has one end portion 104T2 of the open end portion 104 and a corresponding closed end at a boundary formed by pressing the sheet formed into a cylindrical shape by forming the joining side portion 101 into a planar shape. It is formed by connecting one end portion 103T2 of the portion 103.
  • the closed end portion 103 is formed by fusing one of the end portions of the sheet that has been formed into a cylindrical shape by the formation of the joining side portion 101 with heat.
  • the pharmaceutical oral administration device 100 forms a bag shape having three sides closed by the joint side portion 101, the folding side portion 102, and the closed end portion 103.
  • the open end 104 is positioned opposite the closed end 103.
  • the open end 104 has a first open end 104a and a second open end 104b.
  • the first open end 104a and the second open end 104b are positioned to face each other.
  • a semicircular cutout 104c is formed only in the second open end 104b.
  • the first open end 104a is exposed through the notch 104c, so that the medicine is introduced through the notch 104c and the viscous medium integrated with the medicine through the notch 104c is discharged / administered. Can be easily implemented.
  • the intermediate joint portion 105 is formed so as to cross the joint side portion 101 and the bent side portion 102.
  • the intermediate joint 105 includes a first intermediate joint 105a and a second intermediate joint 105b.
  • the first intermediate joint 105a and the second intermediate joint 105b are formed substantially in parallel, and the first intermediate joint 105a is formed on the closed end 103 side with respect to the second intermediate joint 105b. Is done.
  • the intermediate joint portion 105 is formed by placing a viscous medium in a medium sealing portion 203 (described later) and then fusing the sheet with heat.
  • the intermediate joint 105 is formed so that the viscous medium does not leak from the medium enclosure 203 when being carried or transported, and the viscous medium can be easily taken out from the medium enclosure 203 during use.
  • the intermediate joint portion 105 is formed so as to have a fusion strength such that the fusion is peeled off when the internal pressure of the viscous medium sealing portion 203 becomes higher than a predetermined level.
  • the discharge port forming joint portion 106 is located between the medium enclosing portion 203 and a drug placement portion 201 (described later), and cuts the viscous medium.
  • the discharge port forming joint portion 106 descends from the open end 104 side toward the closed end 103 side so as to connect a predetermined position between the joint side portion 101 and the fold side portion 102 and the fold side portion 102. It is formed as follows. An end 106t on the open end 104 side of the discharge port forming joint 106 is formed at a position away from the joint side 101 by a predetermined distance.
  • the discharge port forming joint 106 has a discharge port 106d for discharging the viscous medium.
  • the discharge port 106d is an opening through which the viscous medium passes when the viscous medium breaks the joint of the intermediate joint portion 105 and moves from the medium sealing portion 203 toward the medicine placement portion 201. Further, the discharge port forming joint portion 106 is formed between the joint side portion 101 and the end portion 106 t of the discharge port forming joint portion 106.
  • the discharge port 106 d is an opening having a distance smaller than the distance between the joining side portion 101 and the folding side portion 102 in the intermediate joining portion 105.
  • the discharge port forming joint 106 includes a first slope joint 106a, a second slope joint 106b, and a support joint 106c.
  • the viscous medium moves along a viscous medium movement line L106 formed by the first inclined joint 106a and the second inclined joint 106b.
  • the first inclined joint portion 106a and the second inclined joint portion 106b are formed obliquely from the open end portion 104 toward the closed end portion 103, respectively.
  • the first inclined joint portion 106a and the second inclined joint portion 106b have different inclination angles. That is, the discharge port forming joint portion 106 does not have a constant inclination angle.
  • the first inclined joint portion 106a has a gentler inclination angle than the second inclined joint portion 106b.
  • the 1st inclination junction part 106a is formed in the open end part 104 side rather than the 2nd inclination junction part 106b.
  • the viscous medium having a predetermined size is stably discharged from the discharge port 106d. be able to.
  • the support joint portion 106c is formed so as to connect from the vicinity of the joint point between the first slope joint portion 106a and the second slope joint portion 106b to the folding side portion 102.
  • the discharge port forming joint portion 106 is formed so that the end portion 106t of the discharge port forming joint portion 106 is located closer to the open end portion 014 than the second intermediate joint portion 105b.
  • the storage state maintaining unit 107 is formed in the closed end portion 103.
  • the storage state maintaining portion 107 is formed as a cut larger than the width of the open end portion 104. Thereby, an end portion different from the closed end portion 103 in the storage state (described later) in which the open end portion 104 is bent can be easily inserted into the storage state maintaining portion 107.
  • the space formed by the bonding side portion 101, the folding side portion 102, and the second intermediate bonding portion 105b functions as a medicine placement portion 201.
  • a predetermined medicine T is placed in the medicine placement unit 201.
  • the drug T to be arranged may have any shape such as a tablet, a capsule, or a granule.
  • the tablet is illustrated as the chemical
  • the space formed by the joining side portion 101, the folding side portion 102, the closed end portion 103, and the first intermediate joining portion 105a functions as the viscous medium enclosing portion 203.
  • a viscous medium having a predetermined viscosity and covering each individual drug and forming a drug-coated medium integrated with the coated drug is encapsulated.
  • so-called jelly is used as the viscous medium.
  • the space formed between the first inclined joint portion 106a, the support joint portion 106c, and the bent side portion 102 functions as the drug receiving portion 205.
  • the drug receiving unit 205 stably holds the drug when the drug oral administration device 100 is used. Thereby, the user of the drug oral administration device 100 can easily mix the viscous medium and the drug.
  • Second Usage Method When the drug oral administration device 100 is used, there are a preparation stage in which a drug such as a tablet T is sealed in the drug placement unit 201 and an oral administration stage in which the drug-coated medium is orally administered. Hereinafter, each stage will be described.
  • the oral medicine administration device 100 is provided to a user (hereinafter referred to as encapsulator) who encapsulates the medicine in a state where a predetermined viscous medium is encapsulated in the viscous medium enclosure 203 in advance.
  • encapsulator a user who encapsulates the medicine in a state where a predetermined viscous medium is encapsulated in the viscous medium enclosure 203 in advance.
  • the preparation stage of the oral drug administration device 100 will be described with reference to FIGS.
  • the encapsulator who intends to enclose the drug T in the drug oral administration device 100 arranges the drug T in the open end 104, moves it in the direction of the arrow a ⁇ b> 31, and inputs it into the drug arrangement unit 201 To do.
  • the open end 104 is opened in a diamond shape.
  • the first open end 104a where the notch 104c is not formed is positioned on the lower side
  • the second open end 104b where the notch 104c is formed is positioned on the upper side, via the notch 104c.
  • the tablet T is arrange
  • the open end 104 Since the open end 104 is opened in a diamond shape, the first open end 104a has a convex shape on the lower side. Therefore, the tablet T can be easily received, and when the tablet T is inserted, it is spilled sideways. Can prevent failure.
  • the encapsulator bends the medicine end portion 104 in the direction of the medicine placement portion 201, that is, the direction of the arrow a ⁇ b> 41, with the open end portion 104 facing inward.
  • the pharmaceutical oral administration device 100 can be in a two-fold state in which the open end 104 is folded.
  • the open end portion 104 is folded, it is folded at a position where at least the notch portion 104c is completely inside.
  • the encapsulator further moves the drug placement part 201 in a state where the open end part 104 is folded along the first intermediate joint part 105a as shown in FIG.
  • the encapsulator After folding in the direction of the viscous medium enclosing portion 203, that is, in the direction of the arrow a51, an end different from the end on the second intermediate joint portion 105b side of the drug placement portion 201, that is, an end where the open end is folded is indicated by an arrow a53.
  • It inserts in the accommodation state maintenance part 107 along a direction.
  • medical agent oral administration apparatus 100 can be made into a three-fold state.
  • medicine oral administration device 100 into a folded state, while being compactly packable the form at the time of carrying can be stabilized.
  • the oral administration person who orally administers the medicine stored in the medicine oral administration device 100 or makes it oral by the other person shows the medicine oral administration device 100 in a trifolded state as shown in FIG. As shown in FIG.
  • the oral administration person presses the viscous medium enclosing portion 203 with a finger.
  • the pressure inside the viscous medium enclosure 203 increases.
  • the internal pressure of the viscous medium enclosing part 203 becomes higher than a predetermined level, the fusion bonding of the intermediate joint part 105 is peeled off, and the viscous medium located inside the medium enclosing part 203 moves in the direction of the medicine placement part 201.
  • the viscous medium is discharged from the arrow a61 direction to the arrow a65 direction along the second inclined joint portion 106b and the first inclined joint portion 106a of the discharge port forming joint portion 106. That is, the viscous medium moves along the viscous medium movement line L106.
  • the viscous medium moves from the intermediate joint portion 105 toward the discharge port 106d, which is an opening having a distance smaller than the distance between the joint side portion 101 and the folding side portion 102 in the intermediate joint portion 105. .
  • the viscous medium is a compression force applied to the viscous medium enclosure 203, that is, the pressure applied to the viscous medium when the viscous medium is directed from the wide medium enclosure 201 to the narrow discharge port 106d, or the viscous medium itself.
  • the material is cut into an appropriate size.
  • the viscous medium is also discharged in the direction of the arrow a63 along the inclined side portion 101a of the joining side portion 101. For this reason, since a viscous medium merges in the vicinity of the intersection of the arrow a61 direction and the arrow a63 direction, cutting is further promoted.
  • the cut viscous medium is discharged from the discharge port 106d to the medicine placement unit 201 along the arrow a67.
  • the cut viscous medium is discharged to the medicine receiving unit 205 side. Since the medicine T is located in the medicine receiving part 205, the cut viscous medium and the medicine T can be easily integrated. Thereby, the medicine covering medium in which the medicine T and the viscous medium located inside the medicine placement unit 201 are integrated can be generated.
  • a drug-coated medium in which the drug is uniformly included in the viscous medium can be generated.
  • the drug-coated medium is moved in the direction of the open end 104, that is, in the direction of the arrow a71, and the drug-coated medium is disposed on the first open end 104a. Then, the drug-coated medium is orally administered from the first open end 104a.
  • Example 1 in Example 1 described above, so-called jelly was used as the viscous medium.
  • the viscous medium has a predetermined viscosity and a predetermined strength, is coated with a drug, and a plurality of coated drugs are integrated.
  • the present invention is not limited to the examples as long as the formed drug-coated medium is formed.
  • tablet T is shown as the drug, but the drug is not limited to the illustrated one as long as it is a drug.
  • the drug may be a mini tablet, pellet, hard capsule, soft capsule, inclusion, granule, powder, API.
  • a supplement for supplementing a predetermined nutrient may be used instead of the drug.
  • Example 1 drug oral administration device 100 Although polypropylene or the like is shown as the material of the sheet forming the above-described Example 1 drug oral administration device 100, the joint side portion 101, the intermediate joint portion 105, and the discharge port forming joint portion 106 can be formed. If there is, it is not limited to the example. For example, you may make it form with soft materials, such as aluminum. Further, it may be transparent or translucent.
  • the storage state maintenance unit 107 is configured by the cut formed in the closed end portion 103.
  • the storage state in which the oral medicine administration device is folded can be maintained. If it is, it is not limited to the thing of illustration.
  • the storage state maintaining unit 307 may be formed in a direction that is continuous with the joint end 103 and in a direction different from the viscous medium enclosing unit 203. .
  • the storage state maintaining unit 307 has an end storage opening that is positioned opposite to the joint end 103. As shown in FIG. 9, with the open end portion 104 folded, the drug placement portion 203 is folded so as to overlap the viscous medium enclosing portion 203. The storage state maintaining unit 307 is also folded so as to overlap the viscous medium enclosing unit 203. Then, one end of the folded drug placement unit 203 is inserted into the end storage opening of the storage state maintaining unit 307, and the storage state of the drug oral administration device 300 during carrying is maintained.
  • the storage state may be maintained by the storage state maintaining unit 407 formed in the side joint region 101r.
  • the storage state maintaining unit 407 is formed in the first cutout 407a, the second cutout 407b formed in the bonding side portion 101 corresponding to the medicine placement portion 203, and the bonding side portion 101 corresponding to the viscous medium enclosing portion 203.
  • the third cutout 407c and the fourth cutout 407d are provided.
  • the first cutout 407 a and the second cutout 407 b are formed as cuts that become narrower from the end of the joining side portion 101 toward the drug placement portion 203.
  • the third cutout 407 c and the fourth cutout 407 d are formed as cuts that widen from the end of the joining side portion 101 toward the viscous medium sealing portion 203.
  • the first notch 407a When forming the storage state during carrying, as shown in FIG. 11A, the first notch 407a, as shown in FIG. 11B in which the X region shown in FIG. A part of the tip of the second notch 407b is inserted into the third notch 407c and the fourth notch 407d, and the first notch 407a and the second notch 407b are inserted into the third notch 407c and the fourth notch. 407d is engaged. Thereby, the medicine oral administration device 400 can be maintained in the housed state.
  • the hatched portions of the first cutout 407a and the second cutout 407b show the portions engaged with the third cutout 407c and the fourth cutout 407d.
  • the discharge port forming joint portion 106 includes the first inclined joint portion 106a and the second inclined joint portion 106b having different inclination angles.
  • the present invention is not limited to the example as long as the inclination angle is not constant.
  • the viscous medium moving line L506 is formed by the arc-shaped discharge port forming joint 506.
  • the divided inclined joint obtained by dividing the first inclined joint portion 106a and the second inclined joint portion 106b of the oral medicine administration device 100 in Example 1 described above into a plurality of parts.
  • the portions 206a to 206d may be formed.
  • the distance between the divided joints may be a distance that allows the viscous medium to move along the respective divided joints without leaking from the gap.
  • the viscous medium movement line L606 is formed by the divided inclined joints 206a to 206d and the space therebetween.
  • Support joint 106c In the drug oral administration device 100 in the first embodiment described above, the discharge port forming joint 106 has the support joint 106c, but like the drug oral administration device 600 shown in FIG. In addition, the support joint 106c may not be formed. Also, the space between the support joint 106c and the second inclined joint 106b shown in FIG. 1 is fused, and the first inclined joint 106a, the second inclined joint 106b, and the support joint 106c are connected. , And may be integrally fused.
  • Side joint region 101r In the oral drug administration device 100 in Example 1 described above, the joint side portion 101 and the external side portion 101e in the side joint region 101r are formed in parallel.
  • the shape is not limited to the illustrated example as long as the joining side portion 101 having a shape can be formed.
  • the outer side portion 651 e may be formed with a side joining region 651 r having a horizontal shape different from that of the joining side portion 101.
  • the joint side portion 101 has the inclined side portion 101a.
  • the joining side portion 701 includes one end portion 104T1 of the open end portion 104 and one end portion 703T1 of the corresponding closed end portion 703 at the boundary of the side joining region 701r on the folded side portion 102 side. Connected to form a straight line.
  • the folded side portion 102 corresponds to one end portion 104T2 of the open end portion 104 at a boundary formed by press-contacting a sheet having a cylindrical shape by forming the joining side portion 101 into a planar shape. It is formed on a straight line connecting one end portion 703T2 of the closed end portion 703.
  • Cylindrical shape of the drug oral administration device 100 In the drug oral administration device 100 in Example 1 described above, the end of one sheet is fused and, as shown in FIG. Although the oral medicine administration device 100 has a cylindrical shape by forming the joint side portion 101, it is not limited to the illustrated one as long as it can have a cylindrical shape. For example, both ends of two sheets are fused, and a joining side portion 101 is formed on one side as in the oral medicine administration device 800 shown in FIG. 802 may be formed.
  • Intermediate joint 105 In the first embodiment, the intermediate joint 105 has the first intermediate joint 105a and the second intermediate joint 105b, but only one of them is formed. May be. Three or more intermediate joints may be formed.
  • Discharge port forming portion In the above-described first embodiment, the discharge port inclined joint portion 106 forms the viscous medium cutting portion that cuts the viscous medium, but the discharge port inclined joint portion 106 is not formed. Alternatively, a viscous medium cutting part may be formed.
  • the discharge port forming unit 806 located between the medium enclosing unit 203 and the drug placement unit 201 is formed.
  • the discharge port forming part 806 is formed by fusing the forming materials positioned opposite to each other in an island shape.
  • the discharge port forming portion 806 is configured by discharge port forming inclined joint portions 806a and 806b.
  • the viscous medium breaks the joint of the intermediate joint portion 105 and moves from the medium sealing portion 203 toward the drug placement portion 201, the viscous medium is discharged from the discharge ports 806d1 to 806d1 ⁇ formed by the discharge port forming inclined joint portions 806a and 806b. Pass 806d3.
  • the discharge ports 806d1 to 806d3 are each formed by an opening having a distance smaller than the distance between the bonding side portion 101 and the folding side portion 102 in the intermediate bonding portion 105.
  • the oral drug administration device 100 has one discharge port 106d, but may have a plurality of discharge ports.
  • the discharge port has an island-shaped joint 906a, and has two discharge ports 906d1 and 906d2 in total, one above and below the island-shaped joint 906a.
  • the forming unit 906 may be formed.
  • the oral drug administration device 100 has a cylindrical shape in which three sides are closed by the joint side portion 101, the bent portion 102, and the closed end portion 103.
  • the present invention is not limited to the illustrated example as long as the bag shape is closed on three sides.
  • the outer shape of the oral drug administration device 1000 may be a fish shape.
  • the present invention stores a drug and a viscous medium in a separated state so that they can be carried, and when orally administered, a drug-coated medium formed by the viscous medium and the drug is formed and orally administered. Can be used as a device.
  • Oral administration device 307 Storage state maintaining unit 400 ⁇ Oral medicine administration device 407... Storage state maintaining unit 407a... First cutout 407b... Second cutout 407c... Third cutout 407d.
  • Oral medicine administration device 506 Drain formation joint portion 600 ⁇ Oral medicine administration device 700 ⁇ Oral medicine administration device 701 ⁇ Joint side portion 800 ⁇ ⁇ Oral drug administration device 802 ⁇ Joint side portion 900 ⁇ Oral drug administration device 1000 ⁇ Oral drug administration device

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif d'administration de médicament par voie orale avec lequel : un médicament et un milieu visqueux peuvent être transportés en étant contenus séparément; et, lors de la prise du médicament par voie orale, après enrobage des médicaments individuels, un milieu d'enrobage de médicament dans lequel les médicaments enrobés sont combinés avec le milieu visqueux peut être facilement formé et administré oralement. Le dispositif d'administration de médicament par voie orale (100) comprend une jonction formant une sortie (106). La jonction formant une sortie (106) comprend une première section de jonction inclinée (106a) et une seconde section de jonction inclinée (106b). La première section de jonction inclinée (106a) et la seconde section de jonction inclinée (106b) ont des angles d'inclinaison mutuellement différents. La première section de jonction inclinée (106a) a un angle d'inclinaison plus graduel que la seconde section de jonction inclinée (106b). La première section de jonction inclinée (106a) est en outre formée sur un côté d'extrémité ouverte (104) de la seconde section de jonction inclinée (106b). En formant la première section de jonction inclinée (106a) et la seconde section de jonction inclinée (106b) avec des angles d'inclinaison différents de telle sorte qu'elles soient contiguës, il est possible d'éjecter de façon stable un milieu visqueux de taille spécifiée par la sortie.
PCT/JP2013/083958 2013-12-18 2013-12-18 Dispositif d'administration de médicament par voie orale WO2015092888A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/JP2013/083958 WO2015092888A1 (fr) 2013-12-18 2013-12-18 Dispositif d'administration de médicament par voie orale
JP2015553279A JP6168160B2 (ja) 2013-12-18 2013-12-18 薬剤類経口投与装置
TW103138906A TWI662959B (zh) 2013-12-18 2014-11-10 Pharmacy oral medication device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2013/083958 WO2015092888A1 (fr) 2013-12-18 2013-12-18 Dispositif d'administration de médicament par voie orale

Publications (1)

Publication Number Publication Date
WO2015092888A1 true WO2015092888A1 (fr) 2015-06-25

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Country Status (3)

Country Link
JP (1) JP6168160B2 (fr)
TW (1) TWI662959B (fr)
WO (1) WO2015092888A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811338B1 (en) * 1999-10-08 2004-11-02 The Procter & Gamble Company Disposable semi-enclosed applicator for distributing a substance onto a target surface
JP2011194048A (ja) * 2010-03-19 2011-10-06 Jms Co Ltd 医療用容器
WO2011122640A1 (fr) * 2010-03-29 2011-10-06 株式会社モリモト医薬 Récipient pour composition pharmaceutique s'administrant par voie orale
WO2012150704A1 (fr) * 2011-05-02 2012-11-08 株式会社モリモト医薬 Récipient pour l'administration d'un médicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4776589B2 (ja) * 2007-06-19 2011-09-21 敏彦 仁科 薬剤服用補助容器
JP3173017U (ja) * 2011-11-01 2012-01-19 葉子 斉藤 薬剤服用器具

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811338B1 (en) * 1999-10-08 2004-11-02 The Procter & Gamble Company Disposable semi-enclosed applicator for distributing a substance onto a target surface
JP2011194048A (ja) * 2010-03-19 2011-10-06 Jms Co Ltd 医療用容器
WO2011122640A1 (fr) * 2010-03-29 2011-10-06 株式会社モリモト医薬 Récipient pour composition pharmaceutique s'administrant par voie orale
WO2012150704A1 (fr) * 2011-05-02 2012-11-08 株式会社モリモト医薬 Récipient pour l'administration d'un médicament

Also Published As

Publication number Publication date
TW201532601A (zh) 2015-09-01
JPWO2015092888A1 (ja) 2017-03-16
TWI662959B (zh) 2019-06-21
JP6168160B2 (ja) 2017-07-26

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