WO2015072517A1 - Timbre - Google Patents

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Publication number
WO2015072517A1
WO2015072517A1 PCT/JP2014/080079 JP2014080079W WO2015072517A1 WO 2015072517 A1 WO2015072517 A1 WO 2015072517A1 JP 2014080079 W JP2014080079 W JP 2014080079W WO 2015072517 A1 WO2015072517 A1 WO 2015072517A1
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WO
WIPO (PCT)
Prior art keywords
patch
sensitive adhesive
support
pressure
skin
Prior art date
Application number
PCT/JP2014/080079
Other languages
English (en)
Japanese (ja)
Inventor
智範 猪飼
彰人 竹崎
藤澤　博充
Original Assignee
ニチバン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニチバン株式会社 filed Critical ニチバン株式会社
Priority to JP2015547788A priority Critical patent/JPWO2015072517A1/ja
Publication of WO2015072517A1 publication Critical patent/WO2015072517A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01034—Non-adhesive bandages or dressings characterised by a property
    • A61F13/01038—Flexibility, stretchability or elasticity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • the present invention relates to a patch, particularly a patch for wound covering or post-surgical wound protection, and further to a patch for healing wounds, treating scars, or preventing formation of scars and keloids.
  • Patent Document 1 discloses a hydrocolloid patch having a specific elongation force.
  • U.S. Patent No. 6,057,056 describes devices, bandages, kits, and methods that are configured to shield wounds from intrinsic and / or extrinsic stresses and can improve scar and / or keloid formation.
  • Patent Document 3 discloses a patch that is applied in accordance with a peripheral zone adjacent to the affected part such as keloid, an elastic body that covers the affected part, and the adhesive material that supports the elastic body from above.
  • a body for treating skin disorders has been disclosed, comprising a support patch that is attached so that at least a part of the elastic body is applied to the elastic body and presses the elastic body toward the affected area.
  • JP 2012-135582 A Special table 2009-545382 Japanese Patent Publication No. 07-079827
  • An object of the present invention is to provide a patch for wound covering or post-operative wound protection, particularly a wound patch that can suppress both elongation and contraction of the skin, has excellent followability to the skin, and can be applied for a long period of time.
  • An object of the present invention is to provide a patch for healing, treatment of scars or prevention of scar / keloid formation.
  • the invention made in order to solve the above-mentioned problems is that the 10% tensile load in at least one of the longitudinal direction and the short direction of the patch is 18 N / 25 mm or more, and the bending resistance (mm) and basis weight (by the cantilever method) g / m 2 ) is a patch for wound covering or postoperative wound protection having a product of 3000 or more.
  • the patch of the present invention can suppress both stretching and shrinkage of the skin, and is excellent in followability to the skin and can be applied for a long time.
  • the patch of the present invention is also excellent in the effect of suppressing the shrinkage of the skin that the conventional patch has not sufficiently provided.
  • the present inventors can sufficiently suppress the elongation of the skin when the 10% tensile load of the patch is 18 N / 25 mm or more, and the product of the bending resistance (mm) and the basis weight (g / m 2 ) by the cantilever method. It has been found that the shrinkage of the skin can be sufficiently suppressed when the ratio is 3000 or more.
  • the gist of the present invention is as follows.
  • “10% tensile load” is measured according to JIS K 7113 of Japanese Industrial Standard.
  • the “bending softness by cantilever method (mm)” can be measured according to JIS L 1096.
  • the “basis weight (g / m 2 )” is the weight (g) per unit area of the patch expressed in grams per square meter.
  • a patch comprising a support and an adhesive layer provided on one side of the support
  • 10% tensile load in at least one of the longitudinal direction and the short direction of the patch is 18 N / 25 mm or more
  • the product of the bending resistance (mm) and the basis weight (g / m 2 ) by the cantilever method is 3000 or more.
  • ⁇ 4> The patch according to any one of ⁇ 1> to ⁇ 3>, wherein the stress relaxation time in at least one of the longitudinal direction and the short direction of the patch is 10 s or more.
  • ⁇ 5> The adhesive material according to any one of ⁇ 1> to ⁇ 4>, wherein the 10% tensile load in the longitudinal direction and the lateral direction is 18 N / 25 mm or more.
  • ⁇ 6> The patch according to any one of ⁇ 1> to ⁇ 5>, wherein the pressure-sensitive adhesive layer contains a urethane-based pressure-sensitive adhesive or a foamed acrylic pressure-sensitive adhesive.
  • ⁇ 7> The patch according to any one of ⁇ 1> to ⁇ 6>, wherein the support comprises a woven fabric or a nonwoven fabric.
  • ⁇ 8> The patch according to any one of ⁇ 1> to ⁇ 7>, wherein the support includes micropores.
  • ⁇ 9> The patch according to any one of ⁇ 1> to ⁇ 8>, which is used for wound healing, scar treatment, or scar / keloid formation prevention.
  • the patch according to ⁇ 9> which is used for healing a wound of a wound by surgery, treating a scar, or preventing scar / keloid formation.
  • a patch comprising a support and an adhesive layer provided on one side of the support, at least one 10% tensile load in the longitudinal direction or the short direction of the patch is 18 N / 25 mm or more.
  • the product of the bending resistance (mm) by the cantilever method and the basis weight (g / m 2 ) is 3000 or more
  • a patch comprising the pressure-sensitive adhesive layer containing a urethane-based pressure-sensitive adhesive or a foamed acrylic pressure-sensitive adhesive.
  • 10% tensile load in at least one of the longitudinal direction and the short direction of the patch is 18 N / 25 mm or more, and the product of the bending resistance (mm) and the basis weight (g / m 2 ) by the cantilever method is 3000 or more.
  • a patch material in which the product of the bending resistance (mm) by the cantilever method and the apparent density (g / cm 3 ) is 25 or more.
  • the patch of the present invention not only the stretch of the skin but also the shrinkage can be suppressed, so that the external force applied to the skin having a wound due to an injury or an operation can be sufficiently reduced.
  • it is excellent in followability to skin, moisture permeability, adhesion, etc., and can be applied for a long time. Therefore, according to the patch of the present invention, it is possible to promote the healing of wounds and the treatment of scars on wounds and wounds after surgery, and to effectively prevent the formation of scars and keloids.
  • the patch of the present invention (hereinafter also referred to as “the patch”) includes a support and an adhesive layer provided on one side of the support. Further, the patch material includes a peeler and / or a carrier as necessary. One or more other layers may be interposed between the support and the support, between the support and the pressure-sensitive adhesive layer, and / or between the pressure-sensitive adhesive layer and the release body. A support body, an adhesive layer, a peeling body, a support body, and other layers will be described later. In addition, let the long direction of a sticking material be a longitudinal direction, and let a short direction be a transversal direction.
  • the direction corresponding to the long side is the longitudinal direction
  • the direction corresponding to the short side is the short direction
  • the longer direction when cut is the longer direction
  • the shorter direction is the shorter direction.
  • the adhesive material has a 10% tensile load of 18 N / 25 mm or more in at least one of the longitudinal direction and the short direction. Since the patch has such physical properties, it is difficult to be deformed by external force, scar tissue extension, or the like, and can sufficiently suppress the elongation of the skin.
  • the tensile load is preferably 18 N / 25 mm or more and 500 N / 25 mm or less, more preferably 18 N / 25 mm or more and 300 N / 25 mm or less, further preferably 20 N / 25 mm or more and 200 N / 25 mm or less, more preferably 25 N / 25 mm or more and 150 N / 25 mm or less is particularly preferable, and 30 N / 25 mm or more and 150 N / 25 mm or less is most preferable.
  • the tensile load is less than 18 N / 25 mm, the patch is likely to be deformed by an external force or the like, and the effect of suppressing the elongation of the skin may be insufficient.
  • the tensile load exceeds 500 N / 25 mm, the elongation of the skin can be suppressed.
  • the adhesive material only needs to satisfy at least one of the longitudinal direction and the short-side direction, but in order to sufficiently reduce the external force on the skin and effectively suppress the elongation of the skin, It is preferable that both the direction and the short direction satisfy the above conditions.
  • the measurement of the tensile load in this invention performed the tensile test according to JISK7113, and measured the 10% tensile load.
  • the patch has a product of bending resistance (mm) and basis weight (g / m 2 ) by the cantilever method of 3000 or more.
  • the value of the product of the bending resistance and the basis weight is related to the effect of suppressing the stretch and contraction of the skin when the patch is applied to the skin, particularly the effect of suppressing the contraction of the skin. Found that there is. That is, the larger the product of the bending resistance and the basis weight, the higher the effect of suppressing skin shrinkage, and the smaller the product, the lower the effect of suppressing skin shrinkage.
  • the patch of the present invention having a product value of 3000 or more can sufficiently suppress the shrinkage of the skin, promote the healing of wounds and the treatment of scars, and can effectively suppress the formation of scars and keloids. .
  • this value is too large, the effect of suppressing the shrinkage of the skin can be obtained, but the followability of the patch to the skin may be reduced, or normal operation may be difficult to perform when the patch is stuck to the skin.
  • the product of the bending resistance and the basis weight is preferably 3000 or more and 70000 or less, more preferably 3300 or more and 20000 or less, and further preferably 3500 or more and 10,000 or less, It is particularly preferably 3500 or more and 8000 or less, and most preferably 4000 or more and 8000 or less.
  • the product of the bending resistance (mm) by the cantilever method and the apparent density (g / cm 3 ) is preferably 25 or more.
  • the value of the product of the bending resistance and the apparent density is also closely related to the effect of suppressing the elongation and contraction of the skin when the patch is applied to the skin, particularly the contraction suppressing effect. I found out. That is, the greater the product of the bending resistance and the apparent density, the higher the skin shrinkage suppressing effect, and the smaller the product value, the lower the skin shrinkage suppressing effect.
  • the patch of the present invention having a product value of 25 or more can sufficiently suppress the shrinkage of the skin, promote the healing of wounds and the treatment of scars, and can effectively suppress the formation of scars and keloids. .
  • the product of the bending resistance and the apparent density is preferably 25 or more and 100 or less, more preferably 25 or more and 70 or less, and further preferably 25 or more and 50 or less, 30 It is especially preferable that it is 50 or more.
  • the apparent density (g / cm 3 ) of the patch is a value obtained by dividing the basis weight (g / m 2 ) by the thickness ( ⁇ m).
  • the moisture permeability is preferably 700 (g / m 2 ⁇ 24 h) or more. Since the adhesive material has a water vapor transmission rate of 700 (g / m 2 ⁇ 24 h) or more, it can be applied for a long time because it has less stuffiness when applied to the skin.
  • the moisture permeability of the patch is more preferably 900 (g / m 2 ⁇ 24 h) or more, further preferably 1000 (g / m 2 ⁇ 24 h) or more, and 1500 (g / m 2 ⁇ 24 h). ) Or more is particularly preferable. The higher the moisture permeability, the better.
  • the upper limit of the preferable moisture permeability is not particularly limited, but is usually 30000 (g / m 2 ⁇ 24 h) or less.
  • the moisture permeability was measured at a temperature of 40 ° C. and a relative humidity of 90% according to the B condition of JIS Z0208. That is, one side of the patch is adjusted to a temperature of 40 ° C. and a relative humidity of 90%, and a moisture absorbent such as calcium chloride is placed on the other side to absorb the moisture that has passed through the patch, and the weight change of the moisture absorbent Was calculated by converting per 1 m 2 for 24 hours.
  • the stress relaxation time of at least one of the longitudinal direction and the short direction is 10 (s) or more. Since the patch material has a stress relaxation time of 10 (s) or longer, even when the patch material is stretched by an external force or the like, it can return to its original state without being stretched. It can promote wound healing and scar treatment for wounds and the like after surgery, and can effectively prevent the formation of scars and keloids.
  • the stress relaxation time of the patch is more preferably 30 (s) or more, further preferably 70 (s) or more, and particularly preferably 100 (s) or more.
  • the stress relaxation time is preferably as high as possible, but is usually 1000 (s) or less.
  • the adhesive material only needs to satisfy the above condition in at least one of the longitudinal direction and the lateral direction, but even when the adhesive material is extended by an external force or the like, the original material is not stretched. In order to be able to return, it is preferable that both the longitudinal direction and the lateral direction satisfy the above conditions.
  • the stress relaxation time is measured by using a strip with a width of 25 mm and a length of 80 mm in each of the short side (CD) direction and the long side (MD) direction of each adhesive material, so that the gap between the chucks is 50 mm. Nichiban Co., Ltd. Carton Tape No. 660 was attached, and the same method as the measurement of the tensile load was performed. After pulling at a speed of 300 mm / min up to 25 N, the load was stopped for 180 seconds when the load became 25 N, and the time (second) when the load decreased to 20 N was defined as the stress relaxation time.
  • the patch has a 10% tensile load, and the product of the bending resistance (mm) and the basis weight (g / m 2 ) by the cantilever method is within the specified range, thereby suppressing skin elongation.
  • shrinkage can be suppressed. That is, the magnitude of 10% tensile load mainly contributes to the suppression of skin elongation, whereas the product of bending resistance (mm) and basis weight (g / m 2 ) mainly suppresses skin shrinkage. This is based on the discovery that these desired effects are exhibited when these values are equal to or greater than a predetermined numerical value, preferably within a predetermined range.
  • the patch is excellent in followability to the skin.
  • the effect of suppressing the shrinkage of the skin can be further improved by setting the product of the bending resistance (mm) and the apparent density (g / cm 3 ) by the cantilever method to 25 or more.
  • the patch is excellent in moisture permeability, it is difficult to cause stuffiness when it is applied to the skin, and it can be applied for a long time.
  • the thickness of the patch is not particularly limited, but is 6 ⁇ m or more and 6 mm or less, preferably 50 ⁇ m or more and 2 mm or less, more preferably 60 ⁇ m or more and 1 mm or less, and more preferably 80 ⁇ m or more and 0. More preferably, it is 5 mm or less.
  • the form of the patch is not particularly limited as long as it includes the support and the adhesive layer.
  • a rectangle, a square, a quadrangle such as a rhombus, a polygon, a sheet-like form appropriately combining these shapes It can be made into a free form according to the purpose, such as a tape form or a roll form continuously formed in a specific direction.
  • R may be appropriately provided at the corners around.
  • the size of these patch materials can also be freely selected according to the purpose, but when applying to wounds on the skin to prevent scarring and keloid formation, the wounds can be covered sufficiently. Must be size.
  • the patch When the patch is used for medical purposes, such as to prevent scars and keloids, and to be applied to wounds on the skin, it is preferably sterilized to prevent bacterial infection, viral infection, etc. .
  • a method generally used for a patch can be used.
  • a ⁇ -ray sterilization method, an electron beam sterilization method, a high-pressure steam sterilization method, an ethylene oxide gas sterilization method, or the like is used. .
  • the support of the patch of the present invention when it is used as a patch, the 10% tensile load in at least one of the longitudinal direction and the short direction is 18 N / 25 mm or more, and the cantilever
  • the product of the bending resistance (mm) by a method and basic weight (g / m ⁇ 2 >) can be 3000 or more, For example, what consists of the following materials is mentioned.
  • Polyesters such as polyethylene terephthalate (PET) and polybutylene terephthalate; Polyamides such as nylon (nylon 6, nylon 66); Polyolefins such as polypropylene, polyethylene, low density polyethylene (LDPE), and high density polyethylene (HDPE); Ethylene / vinyl acetate copolymer (EVA), ethylene / ethyl acrylate copolymer (EEA), ethylene / methyl acrylate copolymer (EMA), ethylene / methyl methacrylate copolymer (EMMA), ethylene / acrylic acid copolymer Olefin copolymers such as coalescence (EAA); Polyvinyl alcohol (PVA); Polychlorides such as polyvinyl chloride and polyvinylidene chloride; Pulp made from wood, etc .; Silicones; It can be selected from polyurethane and the like, or composite materials thereof.
  • a material having low moisture permeability by
  • polyester, polyamide, polyolefin, and polyurethane are preferable as the material for the support.
  • polyethylene terephthalate (PET) nylon, polyethylene, and pulp are more preferable.
  • PET polyethylene terephthalate
  • nylon polyethylene
  • LDPE low-density polyethylene
  • the composite material is preferably a composite material of polyethylene terephthalate (PET) and pulp.
  • the support may be a woven fabric made of the above-mentioned material, or may be a non-woven fabric, a knitted fabric, a film, a foam or the like.
  • a woven fabric and a non-woven fabric are preferable from the viewpoint that the patch has sufficient moisture permeability.
  • the support may be further processed from a woven fabric, a nonwoven fabric, a knitted fabric, a film, a foam, or the like made of the above material.
  • it may be coated with a polyurethane resin, an acrylic resin or the like, or may be laminated with a polyurethane film or the like.
  • the support includes: PET woven fabric with polyurethane coating, PET woven fabric with acrylic coating, PET woven fabric laminated with polyurethane film, PET woven fabric laminated with ether polyurethane film, and composite material of PET and pulp
  • Nonwoven fabrics made of, LDPE film, nylon woven fabric with acrylic coating, and polyurethane foam are preferred supports.
  • the characteristics of the adhesive material largely depend on the physical characteristics of the support.
  • the 10% tensile load in at least one of the longitudinal direction and the short direction of the support is also preferably 18 N / 25 mm or more.
  • the tensile load is preferably 18 N / 25 mm or more and 500 N / 25 mm or less, more preferably 18 N / 25 mm or more and 300 N / 25 mm or less, and further preferably 20 N / 25 mm or more and 200 N / 25 mm or less.
  • 25 N / 25 mm to 150 N / 25 mm is particularly preferable, and 30 N / 25 mm to 150 N / 25 mm is most preferable. If the tensile load of the support is less than 18 N / 25 mm, the patch is likely to be deformed by an external force or the like, and the effect of suppressing skin elongation may be insufficient.
  • both the longitudinal direction and the transversal direction satisfy
  • the breaking strength of the support is preferably 18 N / 25 mm or more, more preferably 50 N / 25 mm or more, and further preferably 100 N / 25 mm or more.
  • additives that are usually used may be added as necessary.
  • the additive include an ultraviolet absorber, an anti-aging agent, a filler, a pigment, a colorant, a flame retardant, and an antistatic agent. These additives may be used alone or in combination, and the content of these additives may be selected in an optimum range depending on the type of the additive. In many cases, the amount is in the range of 0.001 to 30% by mass, preferably 0.01 to 25% by mass, more preferably 0.1 to 20% by mass.
  • UV irradiation to the wound part is blocked by adding an ultraviolet absorber to the support layer or coating the ultraviolet ray absorber on the support layer, so that wound healing, scar treatment, scarring, etc. -It is preferable from the viewpoint of prevention of keloids and the like.
  • the thickness of the support is 5 ⁇ m or more and 5 mm or less, preferably 20 ⁇ m or more and 3 mm or less, and preferably 40 ⁇ m or more and 1 mm or less from the viewpoint that the patch of the present invention sufficiently exhibits the effect of suppressing the stretching of the skin and improves the handleability. Is more preferably 50 ⁇ m or more and 0.5 mm or less, and particularly preferably 60 ⁇ m or more and 0.15 mm or less. If the thickness of the support is less than 5 ⁇ m, the strength of the support is insufficient, and the support may be broken due to friction or the like during use. In addition, handleability may be reduced. On the other hand, if the thickness exceeds 5 mm, it becomes bulky and uncomfortable when it is applied to the skin. In particular, the ability to follow the curved surface of the skin is poor, and it is easy to come into contact with the clothing covered by the adhesive material. There is a risk of peeling off easily.
  • the support can be provided with micropores in order to apply an ointment, cream, gel or the like containing a drug from the top of the support during application.
  • an ointment containing a steroid agent from above the support, inflammation and itching of the wound can be suppressed without peeling off the patch.
  • the size of the micropores is not particularly limited as long as the ointment, cream or gel penetrates into the wound part, but is preferably 0.01 to 30 mm 2 .
  • the pressure-sensitive adhesive layer of the patch of the present invention (hereinafter also referred to as “the pressure-sensitive adhesive layer”) is provided on one side of the support.
  • the pressure-sensitive adhesive layer serves to removably fix the patch of the present invention to the skin.
  • the pressure-sensitive adhesive layer contains at least one pressure-sensitive adhesive. Moreover, it may contain optional components such as a softener, a tackifier, a pH adjuster, a medicinal component, a filler, an antioxidant (antioxidant, antiseptic), a colorant, and a fragrance as necessary.
  • a softener e.g., a tackifier
  • a pH adjuster e.g., a pH adjuster
  • a medicinal component e.g., a tackifier, e.g., a tackifier, a pH adjuster, a medicinal component, a filler, an antioxidant (antioxidant, antiseptic), a colorant, and a fragrance as necessary.
  • the type of pressure-sensitive adhesive contained in the pressure-sensitive adhesive layer is not particularly limited, and examples thereof include a urethane-based pressure-sensitive adhesive, an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, and a silicone-based pressure-sensitive adhesive.
  • Examples of the urethane-based pressure-sensitive adhesive include those made of a urethane resin obtained by reacting a polyol and a polyisocyanate compound.
  • Examples of the polyol include polyether polyol, polyester polyol, polycarbonate polyol, polycaprolactone polyol, and the like.
  • Examples of the polyisocyanate compound include diphenylmethane diisocyanate, tolylene diisocyanate, hexamethylene diisocyanate, and the like.
  • the NCO / OH molar ratio between the polyol and the polyisocyanate compound used in the reaction is 0.7 / 1.00 to 1.00 / 1.00 so that gelation in the reaction is suppressed and the adhesive strength is increased. It is preferable.
  • a usual method such as a bulk polymerization (solid reaction) method in which the reaction is performed in a molten state, a solution polymerization method, or the like can be used.
  • the solvent used in the solution polymerization method include ketone solvents such as methyl ethyl ketone, methyl isobutyl ketone, and cyclohexanone, ester solvents such as ethyl acetate and butyl acetate, ether solvents such as dioxane and tetrahydrofuran, cellosolve, Glycol ether solvents such as carbitol, glycol ether solvents such as cellosolve acetate, amide solvents such as dimethylacetamide and dimethylformamide, aromatic hydrocarbon solvents such as toluene and xylene, alcohols such as methanol, ethanol and isopropanol These solvents are further included such as system solvent
  • a catalyst When producing a urethane-based pressure-sensitive adhesive, a catalyst, an additive, and the like can be used as necessary.
  • the catalyst include general urethanization catalysts such as nitrogen-containing compounds such as triethylamine and triethylenediamine, and organometallic compounds such as dibutyltin dilaurate, tin octylate and tin stearate.
  • the additive include ultraviolet absorbers such as substituted benzotriazoles, antioxidants such as phenol derivatives, and hydrolysis inhibitors.
  • a chain extender can be used in the production of the urethane adhesive.
  • the urethane-based adhesive can be used in combination with a polyisocyanate curing agent to change the adhesive properties. Increasing the cohesive strength by the combined use of a polyisocyanate curing agent is effective in improving problems such as adhesive residue.
  • the polyisocyanate used as the curing agent can also be used, but a polyol adduct of isocyanate obtained by reaction of these with a bifunctional or higher polyol is preferable, and polymeric polyisocyanate, Isocyanurate modified products and carbodiimide modified products are also preferable.
  • Specific examples include Coronate L, Coronate HL, Coronate 3041, Coronate 2030, Coronate 2031, Coronate HX, Millionate MTL, Millionate MR, and the like manufactured by Nippon Polyurethane Industry.
  • Urethane adhesives are highly safe and are practically used as medical polymer materials. High moisture permeability, good adhesion to the skin, flexible, familiar, and low-irritant adhesive. Therefore, it is suitable for an application to be applied to a human body, and is suitable as an adhesive for a medical patch. Moreover, all of adhesiveness, safety, stability as a material, economy, etc. are satisfied.
  • acrylic pressure-sensitive adhesive examples include acrylic acid esters having an alkyl group having 4 to 12 carbon atoms, such as butyl acrylate, isononyl acrylate, 2-ethylhexyl acrylate, 2-hydroxyethyl acrylate, isooctyl acrylate, n-octyl acrylate, and the like. Or homopolymers of methacrylic acid esters; these (meth) acrylic acid esters as the main component, and other monomers such as (meth) acrylic acid, vinyl acetate, vinylpyrrolidone, acrylamide, hydroxyethyl acrylate, hydroxypropyl acrylate, etc. Examples thereof include a copolymer obtained by copolymerizing with one or more other copolymerizable monomers. Other monomers are usually used in the range of 2 to 50% by mass.
  • the acrylic pressure-sensitive adhesive can be obtained by polymerizing a monomer in a nitrogen atmosphere using a peroxide such as benzoyl peroxide as an initiator in an organic solvent such as toluene, hexane, or ethyl acetate.
  • a peroxide such as benzoyl peroxide
  • organic solvent such as toluene, hexane, or ethyl acetate
  • the acrylic pressure-sensitive adhesive obtained by this method is called a solvent-type acrylic pressure-sensitive adhesive.
  • An emulsion acrylic pressure-sensitive adhesive obtained by emulsifying and dispersing the monomer in water with an emulsifier and then polymerizing can also be used.
  • the acrylic pressure-sensitive adhesive is cross-linked using a cross-linking agent such as a polyvalent isocyanate-based cross-linking agent, a polyvalent epoxy resin-based cross-linking agent, or a polyvalent metal-based cross-linking agent.
  • a cross-linking agent such as a polyvalent isocyanate-based cross-linking agent, a polyvalent epoxy resin-based cross-linking agent, or a polyvalent metal-based cross-linking agent.
  • Tetrad-X manufactured by Mitsubishi Gas Chemical Co., Inc.
  • nursem manufactured by Nippon Chemical Industry Co., Ltd.
  • coronate HL coronate L
  • coronate EH manufactured by Nippon Polyurethane Industry Co., Ltd.
  • These crosslinking agents are usually added to the pressure-sensitive adhesive composition when it is prepared.
  • the crosslinking agent is generally used in an amount of 0.01 to 5 parts by mass, preferably 0.05 to 2 parts by mass with respect to 100 parts by mass of the acrylic pressure-sensitive adhesive (acrylic polymer component). That is, the amount of the crosslinking agent used is appropriately selected from the above range in consideration of adhesive properties, cohesiveness, bleeding properties of medicinal components, and the like. If necessary, a liquid component such as a softening agent can be blended in the acrylic pressure-sensitive adhesive.
  • a foamed pressure-sensitive adhesive because air permeability can be improved and cushioning properties can be improved.
  • Foaming of the pressure-sensitive adhesive can be performed by a usual method, and examples thereof include a method of using a foaming agent and a method of using a vaporizing action generated when an aqueous solution or an organic solvent is heated.
  • the rubber-based adhesive examples include rubber-like elastic bodies such as natural rubber, styrene-isoprene-styrene block copolymer, polyisobutylene, polybutene, polyisoprene, and a mixture of two or more thereof, rosin resin, terpene And the like, to which a tackifier such as a resin, a coumarone-indene resin, or a petroleum resin is added.
  • the rubber-based pressure-sensitive adhesive can be added with softening agents such as liquid polybutene, liquid polyisobutylene and mineral oil; fillers such as titanium oxide and zinc oxide; antioxidants such as butylhydroxytoluene and the like. .
  • those having a styrene-isoprene-styrene block copolymer as a main base are preferable from the viewpoint of adhesiveness.
  • silicone pressure-sensitive adhesive examples include a mixture or partial condensate of silicone rubber and silicone resin.
  • silicone rubber examples include a high molecular weight linear polydiorganosiloxane having a silicon functional group such as a silanol group at both ends, and the silicone resin includes a monofunctional siloxane unit and a tetrafunctional siloxane unit, Examples thereof include polyorganosiloxanes having a branched or network structure having a silicon functional group such as a silanol group or a methoxy group in the molecule.
  • such a silicone rubber is a long-chain copolymer of polydimethylsiloxane
  • the silicone resin is an MQ resin (M units ((CH 3 ) 3 SiO 1/2 ) and Q units).
  • MQ resin M units ((CH 3 ) 3 SiO 1/2 ) and Q units).
  • Silicone resin having a three-dimensional structure made of (SiO 2 )).
  • the composition ratio of the silicone rubber / silicone resin constituting the silicone pressure-sensitive adhesive is not particularly limited, but is preferably 30:70 to 60:40, more preferably 35:65 to 45:55 (mass ratio). ).
  • the composition ratio of silicone rubber / silicone resin particularly preferred in the present invention is 40/60 (w / w) (BIO-PSA4501, Dow Corning), 45/55 (w / w) (BIO-PSA4601, Dow Corning) And the like.
  • a silicone-based pressure-sensitive adhesive is a pressure-sensitive adhesive having pressure-sensitive adhesive properties due to silicon functional groups present in the molecule.
  • Examples of the organic group bonded to the silicon atom include various monovalent hydrocarbon groups such as methyl, ethyl, vinyl, and phenyl, and the adhesiveness can be adjusted by selecting the type of substituent.
  • the silicone-based pressure-sensitive adhesive is rich in air permeability and moisture permeability because the intermolecular distance of the polyorganosiloxane that is the main component thereof is large.
  • each pressure-sensitive adhesive may be used alone or in combination of two or more.
  • these pressure-sensitive adhesives may be used only with pressure-sensitive adhesives.
  • hydrogels containing water, organogels containing organic solvents, hydrocolloids added with hydrophilic polymer compounds It may be used as a hydrocolloid adhesive in the form.
  • the pressure-sensitive adhesive layer may be formed as a single pressure-sensitive adhesive, or may be formed by laminating a plurality of pressure-sensitive adhesive layers. When a plurality of pressure-sensitive adhesive layers are laminated, a plurality of different types of pressure-sensitive adhesives or different sizes of pressure-sensitive adhesives can be laminated. For example, a hydrocolloid adhesive smaller than the support can be used as a part of the bandage pad.
  • urethane pressure-sensitive adhesives or foamed acrylic pressure-sensitive adhesives are preferable from the viewpoints of moisture permeability, low irritation, safety, moderate pressure-sensitive adhesiveness, and the like.
  • the adhesive layer may contain a softener, a tackifier, a pH adjuster, a medicinal component, a filler, an antioxidant (antioxidant, preservative), a colorant, and a fragrance as optional components.
  • a softener can reduce the elasticity of the pressure-sensitive adhesive to give flexibility and improve the pressure-sensitive adhesiveness.
  • the softener include mineral oils such as liquid paraffin, liquid isoparaffin, and naphthenic oil; vegetable oils such as olive oil and olive squalane; animal oils such as lanolin, turtle oil, and beeswax; and synthetic oils such as fatty acid triglyceride and silicone oil.
  • the tackifier can be added as needed because it can make it difficult to cohesive failure while imparting appropriate flexibility to the adhesive.
  • tackifiers include natural rosin derivatives, coumarone-indene resins, terpene oligomers, aliphatic petroleum resins, alkyl-modified phenol resins, polyterpene resins, gum rosins, rosin esters, oily phenol resins, coumarone indene resins, petroleum carbonization. A hydrogen resin etc. are mentioned.
  • the type of the pH adjuster is not particularly limited as long as the object of the present invention is not impaired.
  • karaya gum citric acid, phosphoric acid, sodium hydrogen phosphate, anhydrous sodium hydrogen phosphate, pectin, anhydrous citric acid, alkali metal water
  • examples thereof include oxides and buffer solutions of organic acids.
  • the pressure-sensitive adhesive layer can be adjusted to a pH range of 4.0 to 6.0 by adjusting to the pH of normal skin.
  • antibacterial agents for example, antibacterial agents, anti-inflammatory analgesics, steroid agents, anesthetic agents, antifungal agents, vitamin agents and the like can be mentioned.
  • these drugs exert their effects systemically or locally through percutaneous absorption, or exert their effects locally at the site where they are applied.
  • the drug may contain a drug that suppresses the formation of scars and keloids.
  • Such drugs include antiallergic agents, steroidal agents, TGF- ⁇ signal inhibitors and the like. It is known that allergic reactions are involved in symptoms such as the development / progress of scars and keloids, itching and pain.
  • corticosteroids have a variety of actions, but in the skin, they have an effect of suppressing inflammation and an effect of atrophying tissue.
  • TGF- ⁇ has a very important role in maintaining the homeostasis of the living body, but it is known that abnormalities in TGF- ⁇ signal cause various diseases such as scleroderma, scleroderma and various fibrosis. ing. A common cause of these diseases is thought to be excessive tissue fibrosis induced by excessive TGF- ⁇ signal.
  • the thickness of the pressure-sensitive adhesive layer is not particularly limited, but it is preferably 1 ⁇ m or more and 1 mm or less, preferably 10 ⁇ m or more and 0.5 mm or less from the viewpoint of ensuring the fixation to the skin and the balance with the thickness of the support. Is more preferably 20 ⁇ m or more and 0.1 ⁇ m or less.
  • the coating weight (adhesive thickness) at the time of drying of the pressure-sensitive adhesive layer is preferably 1 g / m 2 or more and 1000 g / m 2 or less, more preferably 10 g / m 2 or more and 200 g / m 2 or less, and 20 g / m.
  • the thickness of the pressure-sensitive adhesive layer or the coating weight is equal to or more than the upper limit, moisture permeability and handleability may be deteriorated. On the other hand, if it is less than the lower limit, there is a possibility that the fixation to the skin cannot be secured.
  • the adhesive strength of the adhesive material provided with an adhesive layer on one side is neither too strong nor too weak, and the adhesive strength against bakelite is about 0.3 to 10 N / 25 mm.
  • the thickness is 2.0 to 6.0 N / 25 mm.
  • the adhesive strength to bakelite was determined by attaching a tape test piece prepared by cutting to a length of 150 mm and a width of 25 mm on a bakelite panel in an atmosphere of 23 ° C. and 50% RH, and applying a 2 kg rubber roll to 300 mm / min. The pressure is reciprocated at a speed of 1 mm.
  • the peel force is measured under the conditions of a peel angle of 180 degrees and a peel speed of 300 mm / min to determine the test piece's bakelite adhesive strength. The measurement is performed three times, and the average value is defined as the adhesive strength of the patch to the bakelite (unit: N / 25 mm).
  • the tackiness of the pressure-sensitive adhesive layer provided on the support is neither too strong nor too weak, and is about 0.4 to 10 (N / 5 mm ⁇ ) in probe tack, preferably 0. About 6 to 5.0 (N / 5mm ⁇ ) is preferable.
  • the peel-off body used for the patch of the present invention (hereinafter also referred to as “the peel-off body”) is provided on the surface of the pressure-sensitive adhesive layer opposite to the surface provided with the support. It is provided in a peelable state.
  • the release body release paper, release film and the like commonly used in the field of patch materials can be used.
  • a paper substrate such as high-quality paper or glassine paper subjected to silicone release treatment, a polyester film, or the like can be used.
  • the thickness of the peeled body is not particularly limited, but is usually 20 ⁇ m or more, preferably 40 ⁇ m or more, and the upper limit is about 500 ⁇ m.
  • the carrier used for the patch of the present invention (hereinafter also referred to as “the carrier”) is provided in a peelable state on the surface of the support opposite to the surface on which the pressure-sensitive adhesive layer is provided. It plays the role which improves the manufacturability and operativity of the patch of this invention.
  • this carrier is transparent or translucent in view of visibility so that the application site can be confirmed at the time of application.
  • the carrier has a relatively high elastic modulus with respect to the support and has an elastic modulus of about 3 to 20 times that of the support.
  • a cut may be provided near the center of the carrier, or two carriers may be provided with a gap between the carriers.
  • a tape or a film may be laminated on the upper part of the cut of the carrier, and a mouth portion may be provided as a gripping piece.
  • the mouth portion may be a film, non-woven fabric, woven fabric, or a laminate thereof, may be an adhesive tape, and may be colored.
  • the end portion of the carrier may be in the form of a waveform or a plurality of cuts, or may be formed larger than the support.
  • the carrier used examples include polyolefins such as polyethylene and polypropylene, polyesters such as polyethylene terephthalate, polyamides such as nylon, polyvinyl chloride, and polyvinylidene chloride.
  • polyolefins such as polyethylene and polypropylene
  • polyesters such as polyethylene terephthalate
  • polyamides such as nylon, polyvinyl chloride, and polyvinylidene chloride.
  • it may be a composite carrier laminated with paper, non-woven fabric, woven fabric, knitted fabric, or metal foil. From the viewpoints of cost and cost, polyolefin and polyester films are preferably used.
  • the thickness of the carrier is not particularly limited, but is usually 20 ⁇ m or more, preferably 40 ⁇ m or more, and the upper limit is about 500 ⁇ m.
  • one or more other layers may be interposed between the carrier and the support, between the support and the pressure-sensitive adhesive layer, and / or between the pressure-sensitive adhesive layer and the release body.
  • an undercoat layer, an adhesive layer, or a release agent layer may be provided in order to improve adhesiveness and peelability, or a film, a nonwoven fabric, a woven fabric, or a laminate thereof may be interposed.
  • the method for producing the patch is not particularly limited, and can be produced according to a general method for producing a patch.
  • the pressure-sensitive adhesive layer can be formed, for example, by supplying a pressure-sensitive adhesive to one upper surface of the support or release body by a method such as a coating method or an extrusion method. Moreover, it can form by supplying an adhesive between a support body and a peeling body. Furthermore, the support and the pressure-sensitive adhesive layer can be coextruded.
  • the method of manufacturing a patch includes a step of forming a pressure-sensitive adhesive layer by applying a pressure-sensitive adhesive to the upper surface of the release body layer.
  • the pressure-sensitive adhesive coating method is not particularly limited, such as spread coating, hot melt coating, and emulsion coating, but the melt coating method is particularly preferable when a thin pressure-sensitive adhesive layer having a thickness of 50 ⁇ m or less is obtained. .
  • an adhesive that forms an adhesive layer is applied to the upper surface of a peeled body that is formed in advance in one direction, and the solvent is removed by drying to form an adhesive layer.
  • a patch comprising the support, the pressure-sensitive adhesive layer, and the peelable body laminated in this order can be obtained. it can.
  • the surface of the support may be entirely covered, or may be partially covered.
  • arbitrary forms such as a grid
  • air permeability, moisture permeability, etc. can be further improved, and the irritation at the time of peeling from the skin is further reduced. You can also.
  • the support may be subjected to surface treatment or primer treatment in order to improve the adhesion between the support and the pressure-sensitive adhesive layer.
  • surface treatment of the support for example, any known treatment methods such as embossing, sand matting, corona discharge treatment, plasma treatment, and alkali treatment can be employed.
  • the primer treatment can be performed using any known primer as long as it is a primer that can be used in the composition according to the present invention, for example, using a primer composed of a silane coupling agent or the like. .
  • the patch can suppress not only the expansion of the skin but also the shrinkage when applied to the skin, it can sufficiently reduce the external force applied to the skin having an injury or a wound caused by surgery. it can. Moreover, since it is excellent also in followability to skin, moisture permeability, etc., it can be applied for a long time. Therefore, according to the patch of the present invention, wound healing and scar treatment can be promoted, and scar and keloid formation can be effectively prevented. In particular, it is effective in preventing the formation of scars and keloids.
  • the direction (longitudinal direction and transversal direction) of the sticking material when sticking can be determined according to the size of the wound.
  • the 10% tensile load in the direction perpendicular to the flaw is increased.
  • it can be affixed to the affected area suffering from eczema, burns, acne, pierced holes, BCG inoculation and the like.
  • the wound healing process is one of the biological defense systems that are divided into three stages from the time course, the inflammatory phase, the proliferative phase and the tissue remodeling phase.
  • the inflammatory phase the proliferative phase
  • the tissue remodeling phase the tissue remodeling phase.
  • mechanical strains such as stretching and contraction occur at the wound site
  • the digestion and removal of necrotic tissue by macrophages and the apoptosis of excess cells are suppressed, particularly in the early proliferative phase, leading to scarring of collagen fibers. It is presumed that the reconstruction of the tissue is suppressed and the scar is enlarged to form a keloid.
  • the patch according to the present invention can be used for the treatment of scars caused by trauma or surgery from the viewpoint of promoting wound healing, while scars and keloids are formed in the sense of suppressing the formation of scars and keloids. It can be used for prevention.
  • the usage of the patch is appropriately selected according to the purpose. For example, for the purpose of preventing scar and keloid formation in the wound, it is preferable to continuously apply for about 3 to 12 months. One sticking material can be stuck continuously after it is once stuck until it peels off. This period is usually about 3 to 7 days. After that, it is desirable to apply a new adhesive material, and repeatedly apply a new adhesive material when peeled off.
  • the adhesive material can be used by covering the adhesive material with a dressing material or medical tape as necessary for waterproofing and long-term adhesion.
  • Adhesive Urethane adhesive has a molar ratio of polyether polyol A / polyether polyol B / polyether monool C (mass ratio 43/21/36) in the isocyanate prepolymer with respect to hydroxyl group 100 in the active hydrogen compound.
  • a urethane-based pressure-sensitive adhesive to which hexamethylene diisocyanate prepolymer was added so as to have an isocyanate group of 90 was used.
  • the acrylic adhesive acrylic adhesive 1, acrylic adhesive 2, and acrylic adhesive 3 were used.
  • the acrylic pressure-sensitive adhesive 1 is a coronate (registered as a cross-linking agent) with respect to 100 parts by mass of an alkyl acrylate copolymer comprising isononyl acrylate / 2-methoxyethyl acrylate / acrylic acid (mass ratio 68/30/2).
  • An acrylic pressure-sensitive adhesive to which 0.3 part by mass of HL manufactured by Nippon Polyurethane Industry Co., Ltd.
  • Acrylic pressure-sensitive adhesive 2 is TETRAD (registered trademark) X 0.02 parts by mass as a crosslinking agent with respect to 100 parts by mass of an acrylic acid alkyl ester copolymer consisting of isononyl acrylate / acrylic acid (mass ratio 98/2). It is an acrylic pressure-sensitive adhesive to which 0.1 part by mass of Nasem aluminum (manufactured by Nippon Chemical Industry Co., Ltd.) is added.
  • the acrylic pressure-sensitive adhesive 3 was used as a crosslinking agent with respect to 100 parts by mass of an acrylic acid alkyl ester copolymer composed of isononyl acrylate / acrylic acid (mass ratio 96/4), and 0.03 parts by mass of TETRAD (registered trademark) X It is an acrylic adhesive with the addition of Mitsubishi Gas Chemical Co., Ltd.
  • Base material (support) As a substrate (support), PET woven fabric + PU coating (polyester woven fabric with polyurethane coating), PET woven fabric + PU film laminated product (polyester woven fabric laminated with polyurethane film), PET / pulp nonwoven fabric (nonwoven fabric containing polyester and pulp), Nylon woven fabric + acrylic coating (Nylon woven fabric with acrylic coating), PET woven fabric + acrylic coating (polyester woven fabric with acrylic coating), PET woven fabric + PU film laminated product (polyester woven fabric laminated with ether polyurethane film), Polyurethane film, PP spunbond nonwoven fabric (polypropylene long fiber nonwoven fabric), A polyurethane nonwoven fabric was used.
  • Example 2 [Examples 2, 5 to 7, and Comparative Example 1] Except that the base material described in Table 1 below was used, the patch materials of Examples 2, 5 to 7 and Comparative Example 1 were prepared in the same manner as in Example 1. The adhesive thickness of each obtained patch was also shown in Table 1. The characteristics of each patch were similarly measured using the method described later and are shown in Table 2.
  • Example 3 Apply an ethyl acetate solution of acrylic pressure-sensitive adhesive 1 (the total solid content is about 40% by mass) to one side of the peeled body so that the thickness after drying is 39 g / m 2 , and then dry, A layer was formed, and a PET / pulp nonwoven fabric was laminated as a support to prepare a patch.
  • acrylic pressure-sensitive adhesive 1 the total solid content is about 40% by mass
  • Example 4 and Comparative Examples 2 to 4 Except that the pressure-sensitive adhesive and the base material described in Table 1 below were used, patch materials of Example 4 and Comparative Examples 2 to 4 were prepared in the same manner as Example 3. The adhesive thickness of each obtained patch was also shown in Table 1. The characteristics of each patch were similarly measured using the method described later and are shown in Table 2.
  • the upper crosshead was raised at a speed of 300 mm / min, and the test piece was pulled.
  • the load when the tensile length reached 10% based on the original test piece was defined as a 10% tensile load.
  • the unit of tensile load was expressed as Newton (N) / 25 mm.
  • Three test pieces were cut in each of the short (CD) direction and the long (MD) direction of each patch, and the measurement was performed on all three sheets. The average value of the three sheets was taken as the measured value of the tensile load in each of the CD direction and MD direction.
  • the measurement conditions are summarized as follows.
  • the moisture permeability was measured at a temperature of 40 ° C. and a relative humidity of 90% in accordance with B condition of JIS Z 0208. That is, one side of each patch is adjusted to a temperature of 40 ° C. and a relative humidity of 90%, and about 15 g of a hygroscopic agent (calcium chloride) is placed on the other side to absorb the moisture that has passed through each patch. The mass change amount of the hygroscopic agent was converted to 1 m 2 per 24 hours, and the average value of the three test pieces was defined as moisture permeability.
  • a hygroscopic agent calcium chloride
  • Stress relaxation time As the test piece of each patch, one obtained by cutting three strips each having a width of 25 mm and a length of 80 mm in each of the short side (CD) direction and the long side (MD) direction was used. Nichiban Co., Ltd. Carton Tape No. is attached to both ends so that the distance between chucks is 50 mm. A test piece for measuring tensile strength was prepared by attaching 660. After pulling at a speed of 300 mm / min up to 25 N, the load was stopped for 180 seconds when the load became 25 N, and the time (second) when the load decreased to 20 N was defined as the stress relaxation time. The measurement conditions are summarized as follows.
  • the patch for wound covering or post-operative wound protection of the present invention not only the expansion of the skin but also the shrinkage can be suppressed, so that the external force applied to the skin having a wound due to trauma or surgery can be sufficiently reduced. it can. Moreover, since it is excellent also in followability to skin, moisture permeability, etc., it can be applied for a long time. Therefore, the patch for wound covering or protecting a postoperative wound according to the present invention is suitable for wound healing, scar treatment or prevention of scar or keloid formation.

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Abstract

La présente invention concerne un timbre pour le recouvrement d'une plaie ou la protection d'une lésion postopératoire, qui peut supprimer l'étirement et la contraction de la peau, suit parfaitement les contours de la peau et peut adhérer longtemps. Ce timbre de recouvrement d'une plaie ou de protection d'une lésion postopératoire comprend un corps de support, ainsi qu'une couche adhésive située sur une surface du corps de support, la charge de tension de 10 % dans la direction longue et/ou la direction courte du timbre étant supérieure ou égale à 18 N/25 mm et le produit de la résistance à la flexion (mm) selon un procédé en porte-à-faux et du poids de base (g/m2) étant supérieur ou égal à 3 000.
PCT/JP2014/080079 2013-11-15 2014-11-13 Timbre WO2015072517A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017064083A (ja) * 2015-09-30 2017-04-06 株式会社麻生 臍ヘルニア治療材固定用貼付材
KR20190075578A (ko) * 2017-12-21 2019-07-01 주식회사 엘지화학 항균 드레싱 필름용 조성물 및 항균 드레싱 필름

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59183751A (ja) * 1983-04-01 1984-10-18 冨士森　良輔 医療用貼付材
JP2007037562A (ja) * 2005-07-29 2007-02-15 Sekisui Chem Co Ltd 乳房用皮膚外用貼付剤
JP2009545382A (ja) * 2006-08-03 2009-12-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 傷跡および／またはケロイドの治療または防止のためのデバイスならびに包帯、ならびにそのための方法およびキット
JP2012135582A (ja) * 2010-12-28 2012-07-19 Alcare Co Ltd 貼付材

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59183751A (ja) * 1983-04-01 1984-10-18 冨士森　良輔 医療用貼付材
JP2007037562A (ja) * 2005-07-29 2007-02-15 Sekisui Chem Co Ltd 乳房用皮膚外用貼付剤
JP2009545382A (ja) * 2006-08-03 2009-12-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 傷跡および／またはケロイドの治療または防止のためのデバイスならびに包帯、ならびにそのための方法およびキット
JP2012135582A (ja) * 2010-12-28 2012-07-19 Alcare Co Ltd 貼付材

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017064083A (ja) * 2015-09-30 2017-04-06 株式会社麻生 臍ヘルニア治療材固定用貼付材
KR20190075578A (ko) * 2017-12-21 2019-07-01 주식회사 엘지화학 항균 드레싱 필름용 조성물 및 항균 드레싱 필름
KR102224033B1 (ko) 2017-12-21 2021-03-08 주식회사 엘지화학 항균 드레싱 필름용 조성물 및 항균 드레싱 필름

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