WO2015011750A1

WO2015011750A1 - Moisturizing agent

Info

Publication number: WO2015011750A1
Application number: PCT/JP2013/069747
Authority: WO
Inventors: 豊明小林; 上原　静香
Original assignee: 株式会社コーセー
Priority date: 2013-07-22
Filing date: 2013-07-22
Publication date: 2015-01-29
Also published as: JP6382815B2; WO2015012198A1; CN105263471B; HK1213786A1; TWI636797B; TW201507733A; JPWO2015012198A1; CN105263471A

Abstract

The purpose of the present invention is to provide an excellent moisturizing agent. This moisturizing agent includes: a sugar fermentation product (A) obtained using a yeast belonging to Kluyveromyces; and a polyhydric alcohol (B) having a specific gravity at 20˚C of at least 0.93. The polyhydric alcohol (B) may have a specific gravity at 20˚C of at least 1.01. Furthermore, the polyhydric alcohol (B) may be at least one selected from glycerin, propanediol, propylene glycol, and dipropylene glycol.

Description

Moisturizer

The present invention relates to a humectant.

Moisturizing ingredients are blended in topical skin preparations, cosmetics, quasi-drugs, and the like for the purpose of adjusting moisture on the skin surface to give moist and moist feeling to the skin and hair.
When the water content of the stratum corneum in the outermost layer of the skin epidermis decreases and the moisture retention function decreases, the skin barrier function tends to decrease. When the skin barrier function is lowered, for example, skin troubles such as dry skin, wrinkles, and rough skin are likely to occur, and improvement of skin inflammation is delayed.
For this reason, increasing and retaining the moisture in the stratum corneum has been expected to be used for various purposes because it leads to keeping the skin soft, elastic and protecting the dermis. As such a moisturizing component, for example, glycerin having high hygroscopicity has been used. However, these components are easily affected by the surrounding humidity, and do not exhibit a sufficient effect on dry skin, but also have the problem of taking away moisture from the skin and promoting drying.
For this reason, at present, attention is focused mainly on biological component-derived or biologically similar components. Specifically, NMF (NATURAL MOISTURIZING FACTOR) sodium lactate, amino acids (eg, glycine, β-alanine, etc.), high molecular compounds such as hyaluronic acid, soluble collagen, ceramide, etc. are used.
For example, Patent Document 1 proposes a humectant containing lysyl-β-alanine or a salt thereof.
However, since users are seeking various moisturizing ingredients, research and development of further moisturizing ingredients is underway.

International Publication No. 2008/1266652 Pamphlet

Therefore, the present invention is intended to provide an excellent moisturizing agent in view of such circumstances.

Therefore, as a result of intensive studies, the present inventor has (A) a sugar fermented product obtained from yeast belonging to the genus Kluyveromyces, and (B) a specific gravity at 20 ° C. of 0.93 or more. It has been found that an excellent moisturizing effect can be obtained by using together with a monohydric alcohol, and the present invention has been completed.

Thus, the present invention provides the following components (A) and (B):
(A) Sugar fermented product from yeast of the genus Kluyveromyces (B) A humectant containing a polyhydric alcohol having a specific gravity at 20 ° C. of 0.93 or more is provided.
The polyhydric alcohol of component (B) may be a polyhydric alcohol having a specific gravity at 20 ° C. of 1.01 or more.
The polyhydric alcohol of component (B) may be one or more selected from glycerin, propanediol, propylene glycol, and dipropylene glycol.

According to the present invention, an excellent moisturizing agent can be provided.

It is a figure which shows the result of the moisturizing effect (change rate when application is set to 1) confirmation test of brown sugar fermented liquor and polyhydric alcohol. It is a figure which shows the result of the moisturizing effect (change rate of brown sugar fermentation liquid / change rate of purified water) confirmation test of brown sugar fermentation liquid and polyhydric alcohol.

The moisturizing agent of the present disclosure contains, as active ingredients, component (A) a sugar fermented product of Kluyveromyces yeast and component (B) a polyhydric alcohol having a specific gravity at 20 ° C. of 0.93 or more. Is.

The “component (A) sugar fermented product of yeast of the genus Kluyveromyces” (hereinafter also referred to as “component (A) sugar fermented product”) used in the present disclosure will be described.

The “Kluyveromyces yeast” used in the present disclosure is not particularly limited, and one or more of the following exemplified yeast species can be selected and used.
Examples of the “Kluyveromyces genus (Kluyveromyces) yeast” include, for example, Kluyveromyces thermotolerans, Kluyveromyces africanus, Kluyveromyces fragilis, Kluyveromyces lactis, Kluyveromyces phaffii, Kluyveromyces waltii, Kluyveromyces wickerhamii, Kluyveromyces wickerhamii, Kluyveromyces warrowhamii Is mentioned.
Of these, Kluyveromyces thermotolerans, Kluyveromyces lactis, and Kluyveromyces fragilis, more preferably Kluyveromyces fragilis. Tolerance (Kluyveromyces thermotolerans).
These yeasts have long been used for producing dairy products such as cheese and yogurt, wine, and fermented foods such as pickles. For example, Kluyveromyces thermotolerance has been reported as a lactic acid-producing yeast isolated from wine brewing and plum jam fermentation products along with its biochemical and physiological properties (Reference 1: The Yeasts.A). Taxonomic Study, 4th ed. Elsevier Science BV, Amsterdam. 240-241 (1998)). Examples of Kluyveromyces thermotolerans include Kluyveromyces thermotolerans MA KT (NITE BP-1420).
Thus, the Kluyveromyces genus yeast used in the present disclosure is an extremely safe microorganism for the human body and can also eat sugar as a fermentation raw material. Therefore, the component (A) sugar of the present disclosure Fermented products are considered to be highly safe.

The “sugar” used as a raw material for the component (A) fermented sugar of the present disclosure is not particularly limited, and those containing sucrose are preferable. The “sugar” may be in any form such as powder or liquid.
As the component (A) of the present disclosure, sugar derived from sugarcane is preferable, and sugarcane sugar obtained from sugarcane squeezed juice is more preferable. Examples of sugars derived from sugarcane include unpurified sugars such as Wasanbon, molasses, black honey, honey-containing sugar, crude sugar, brown sugar, and the like; and refined sugars such as upper white sugar and granulated sugar. More than one species can be selected. Of these, unpurified sugar that has not been purified to upper white sugar is preferred, and among the unpurified sugars, brown sugar is preferred. Brown sugar is produced by heating and concentrating sugarcane squeezed juice, and is preferably not subjected to separation and purification of sugar.
The “sugarcane” of the present disclosure is a plant belonging to the genus Sugarcane (sugar cane, scientific name: Saccharum officinarum), and is also called sweet potato.

The component (A) sugar fermented product of the present disclosure is preferably a fermented product obtained by culturing Kluyveromyces yeast in a sugar-containing medium.
The content of sugar in the sugar-containing medium of the present disclosure is not particularly limited, but is preferably 3 to 15% by mass, more preferably 4 to 8% by mass.
In addition, the sugar-containing medium of the present disclosure is preferably a liquid. Examples of the sugar-containing liquid medium include an aqueous sugar solution obtained by mixing the above-described sugar and water. The water is not particularly limited. For example, pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, purified water, ion-exchanged water, physiological saline, phosphate buffer, phosphorus Examples include acid buffered saline.
Furthermore, the sugar-containing medium preferably contains medium components (for example, a carbon source, a nitrogen source, inorganic salts, etc.) usually used for yeast in terms of improving the productivity of the fermented product. In addition, it is preferable to use a saccharide-containing medium that has been sterilized (for example, heated or film-treated) in order to prevent the propagation of various bacteria.

The culture method of the Kluyveromyces genus yeast is not particularly limited as long as it is a culture method usually used for yeast, and can follow a known method (for example, see Reference 1).
For example, shaking culture, aeration culture, stationary culture, stirring culture and the like can be mentioned. Moreover, any of a batch type and a continuous type may be sufficient. These can be performed alone or in combination of two or more.
The culture conditions (for example, aerobic, anaerobic, pH in the medium, dissolved oxygen, culture temperature, culture time, etc.) of the Kluyveromyces yeast are not particularly limited, and can be appropriately selected according to the purpose. it can.

The component (A) fermented sugar of the present disclosure is preferably prepared by aerobic culture in a sugar-containing medium inoculated with pre-cultured Kluyveromyces yeasts. At this time, it is preferable to add 1% of the preculture solution to the sugar-containing medium. At this time, it is preferable to perform the aerobic culture at a medium pH of 5 to 7 at 15 to 35 ° C. for 1 to 3 days. As the preferred culture, it is desirable to perform shaking culture or stirring culture under aerobic conditions. In the case of aerobic conditions, air (about 20% by volume of oxygen) treated with a sterilization filter may be used.
In addition, the preparation of the present disclosure does not actively perform ethanol fermentation as in alcoholic beverage production, but the ethanol concentration in the sugar fermentation product after the preparation is less than 1% by mass (preferably 0.1% by mass or less) ) Is preferable in terms of the moisturizing effect.

The component (A) sugar fermented product of the present disclosure can be used as it is or after it is dried. In addition, after preparation of the present disclosure, cells of Kluyveromyces genus yeast may be removed by a conventional method such as centrifugation or membrane treatment.
In addition, the component (A) fermented sugar product of the present disclosure may be a diluted solution, a concentrated solution, or a dried product, and may be a separated product or a purified product according to the purpose. When diluting, a physiological saline solution may be used, and when drying, a freeze drying method or a spray drying method may be used. For separation and purification, conventional methods such as centrifugation, precipitation, and chromatography may be used for the purpose of removing impurities, and activated carbon, adsorbents, ion exchange resins, etc. for the purpose of deodorization and decolorization. May be used.
Moreover, you may use 2 or more types of sugar fermented products obtained with different yeast seed | species.

The “component (B) polyhydric alcohol having a specific gravity at 20 ° C. (g / mL at 20 ° C.) of 0.93 or more” (hereinafter also referred to as “component (B) polyhydric alcohol”) used in the present disclosure will be described. . The component (B) of the present disclosure can be prepared by selecting one or more of the following examples of the component (B) polyhydric alcohol.

Component (B) “polyhydric alcohol having a specific gravity of 0.93 or more at 20 ° C.” of the present disclosure includes methylene glycol, glycol (ethylene glycol), propylene glycol, propanediol (1,3-propanediol), diethylene glycol Coal, methylenepropanediol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 2,3-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1, 4-pentanediol, 1,5-pentanediol, 2,4-pentanediol, 1,2-cyclopentanediol, 1,3-cyclopentanediol, neopentyl glycol, isopentyldiol, aminoethylpropanediol, 1, 2-hexanediol, 1,6-hexanedio , Triethylene glycol, dipropylene glycol, butoxydiglycol, ethylhexanediol, butylethylpropanediol, 1,10-decanediol, equol, polyethylene glycol, polypropylene glycol, glycerin, trimethylolethane, trimethylolbutane, 1, Examples include 2,6-hexanetriol, phytanetriol, pentaerythritol, diglycerin, polyglycerin and the like.

The specific gravity (g / mL at 20 ° C.) of the component (B) polyhydric alcohol of the present disclosure is preferably 1.01 or more, more preferably 1.03 or more. When used together, the moisture retention can be further improved, which is preferable. Moreover, the specific gravity (g / mL at 20 ° C.) of the polyhydric alcohol of the present disclosure is preferably 2 or less.
The alcohol valence of the polyhydric alcohol is preferably 2 to 4, more preferably 2 to 3.
The component (B) polyhydric alcohol preferably has 6 or less carbon atoms, more preferably 2 to 4 carbon atoms.
The refractive index of the component (B) polyhydric alcohol is preferably 1.3 to 1.6, more preferably 1.4 to 1.5.

Of the component (B) polyhydric alcohols, propylene glycol, propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, dipropylene glycol and glycerin are preferred.
Furthermore, propylene glycol, propanediol, dipropylene glycol and glycerin are more preferable among the components (B) from the viewpoint of improving moisture retention.

The “specific gravity at 20 ° C.” of the polyhydric alcohol is a value measured by the specific gravity measurement method No. 1 described in the Ministry of Health, Labor and Welfare: Quasi-drug raw material standard 2006 (published by Yakuji Nipposha).
The “refractive index at 20 ° C.” of the polyhydric alcohol is a value measured by a refractive index measurement method described in Japan Ministry of Health, Labor and Welfare: Quasi-drug raw material standard 2006 (published by Yakuji Nippo).

The preparation of the humectant of the present disclosure combines the component (A) sugar fermented product and the component (B) polyhydric alcohol, and therefore, these may be mixed. When combining these, it is preferable to use a sugar fermentation liquid (preferably an aqueous solution) as the component (A) sugar fermentation product.
The content ratio of the component (A) sugar fermented product and the component (B) polyhydric alcohol in the moisturizing agent of the present disclosure (parts by mass of dry solids: parts by mass) is not particularly limited, but from the viewpoint of improving moisturizing properties. The ratio is preferably 0.09: 0.5 to 0.09: 30, more preferably 0.09: 1 to 0.09: 20, and still more preferably 0.09: 5 to 0.09: 10.
In addition, the content of the component (B) polyhydric alcohol in the moisturizing agent is preferably 1 to 30% by mass, more preferably 5 to 20% by mass. In addition, it is possible to adjust so that it may become 100 mass% of humectants using water.
Moreover, the form of the moisturizing agent of the present disclosure to be obtained is not particularly limited, but liquid or semi-solid is preferable.

As shown in the below-mentioned Examples, by containing the component (A) fermented sugar and the component (B) polyhydric alcohol, the moisture retention can be dramatically improved as compared with the case where each component is used alone. Admitted. Therefore, since the mixture of the component (A) and the component (B) has a very excellent moisturizing property, it may be used for moisturizing and various preparations intended for use for moisturizing. It can also be used to produce these various formulations.
Moreover, since the combination of the said component (A) and the said component (B) has the outstanding moisturizing property, it is used for the method for aiming at prevention, improvement, and / or treatment of various symptoms, conditions, etc. regarding skin by moisturizing. can do. Examples of the various symptoms and conditions include rough skin, wrinkle formation, skin aging, xeroderma, dandruff, and the like. Moreover, the combination of the said component (A) and the said component (B) can give a moist feeling to a target object (for example, skin, hair, foodstuff, etc.). For example, the combination of the said component (A) and the said component (B) can be used in order to give a moist feeling and a feeling of unity to hair, and, thereby, can suppress hairiness.
Therefore, the component (A) sugar fermented product and the component (B) polyhydric alcohol are used in order to improve or impart moisturizing properties, such as external preparations for skin, cosmetics, quasi drugs, pharmaceuticals, foods and functional foods. (For example, food for specified health use) and the like (hereinafter also referred to as “formulation”) and the like. The moisturizing agent of the present disclosure can be the above-mentioned external preparation for skin, cosmetics, foods and the like. Moreover, you may make these preparations contain the moisturizer containing the said component (A) of this indication, and the said component (B).

The humectant of the present disclosure or the component (A) fermented sugar and the component (B) polyhydric alcohol are particularly suitable for use in external preparations for skin, cosmetics, quasi drugs, etc. A preparation to be contacted by application or the like is preferable. Examples of skin external preparations and cosmetics include skin lotions, emulsions (oil-in-water type, etc.), creams (oil-in-water type), pack cosmetics, liquid foundations, ointments, hair nourishing agents, hair protectants and the like.

The content of the component (A) fermented sugar in the preparation of the present disclosure is preferably 0.001 to 0.095% by mass, more preferably as a dry solid content, from the viewpoint of the stability of the preparation and moisture retention. It is 0.005 to 0.05 mass%, more preferably 0.001 to 0.02 mass%.
The content of the component (B) polyhydric alcohol in the preparation of the present disclosure is preferably 1 to 50% by mass, more preferably 5 to 40% by mass, and further preferably 10 to 30% from the viewpoints of safety and moisture retention. % By mass.
The content ratio of the component (A) sugar fermented product and the component (B) polyhydric alcohol in the formulation of the present disclosure (parts by mass of dry solids: parts by mass) is not particularly limited, but the stability and moisture retention of the formulation From this viewpoint, it is preferably 0.01: 5 to 0.01: 500, more preferably 0.01: 10 to 0.01: 300, and still more preferably 0.01: 20 to 0.01: 200.

In addition, the moisturizer of the present disclosure and the preparation of the present disclosure are necessary as long as the effects of the present technology are not impaired in addition to the component (A) fermented sugar and the component (B) polyhydric alcohol of the present disclosure. Depending on the situation, optional components may be used in combination. Other components may be pharmaceutically acceptable components, such as preservatives, cell activators, antioxidants, humectants, UV inhibitors, solvents (water, alcohols, etc.), oils, interfaces Activator, Thickener, Powder, Chelating agent, pH adjuster, Emulsifier, Stabilizer, Colorant, Brightener, Flavoring agent, Flavoring agent, Excipient, Binder, Disintegrant, Lubricant, Dilution Agents, osmotic pressure adjusting agents, fragrances and the like, and these may be added according to the intended preparation.
The form of the preparation is not particularly limited, and may be any form such as liquid, paste, gel, solid, and powder.

In addition, this technique can also employ | adopt the following structures.
[1] The following components (A) and (B);
(A) Sugar fermented product from yeast of the genus Kluyveromyces (B) A humectant containing a polyhydric alcohol having a specific gravity at 20 ° C. of 0.93 or more.
[2] The humectant according to [1], wherein the sugar fermentation product is a fermentation product derived from sugarcane sugar.
[3] The humectant according to [1] or [2], wherein the fermented sugar product has an ethanol concentration of less than 1% by mass.
[4] The humectant according to any one of [1] to [3], wherein the polyhydric alcohol of component (B) is a polyhydric alcohol having a specific gravity at 20 ° C. of 1.01 or more.
[5] Any one of [1] to [4], wherein the polyhydric alcohol of component (B) is one or more selected from glycerin, propanediol, propylene glycol, and dipropylene glycol. The humectant described.

[6] The yeast belonging to the genus Kluyveromyces is one selected from Kluyveromyces thermotolerans, Kluyveromyces lactis and Kluyveromyces fragilis The humectant according to any one of [1] to [5], which is two or more kinds.
[7] The component (A) fermented sugar product is a fermented product obtained by culturing Kluyveromyces yeast in a sugar (preferably unpurified sugar) -containing medium. The humectant according to any one of the above.

Examples, Reference Examples, Comparative Examples, Test Examples, Production Examples, etc. are given below to describe the present invention (present technique) more specifically. However, the present invention (present technique) is not limited to these examples. It is not something.

<Preparation Example 1: Preparation of brown sugar fermentation broth by Kluyveromyces thermotolerans>
[Pre-culture]
Liquid culture of Kluyveromyces thermotolerance MA KT (NITE BP-1420) was performed using YPD medium (pH 6.0). One platinum loop of the liquid culture solution was taken and inoculated into a YM medium (solid medium), and precultured at 25 ° C. for 2 days. Incidentally, YPD (Yeast Extract-Peptone- Dextrose) medium and YM (Yeast Mold) media are those made in accordance with what is described in ^{^{Difco TM & BBL TM Manual, 2}} nd Edition.
Kluyveromyces thermotolerans MA KT (NITE BP-1420) is a country of origin: Japan / source: collected from sap, classified as Lachancea (Kluyveromyces) thermotolerans based on morphology and bacteriological properties, and named MA KT It is. The strain was deposited on September 13, 2012 at the depository: 2-5-8, Kazusa Kamashichi, Kisarazu City, Chiba Prefecture 292-0818, Japan, and the National Institute of Technology and Technology (NPMD). It is what.

[Preparation of brown sugar aqueous solution]
500 parts by mass of pure water was added to 25 parts by mass of brown sugar to obtain a 5% by mass brown sugar aqueous solution. The 5 mass% brown sugar aqueous solution was sterilized together with the aeration and stirring type fermenter, and then adjusted to an appropriate temperature.
As brown sugar, a commercial product produced by heating and concentrating sugarcane stem juice was used.

[Fermentation process]
A colony obtained by pre-culture of the Kluyveromyces thermotolerans was suspended in physiological saline to obtain 1.0 × 10 ⁹ CFU / mL to 1.0 × 10 ¹⁰ CFU / mL. 1% by mass of the total amount of the 5% by mass brown sugar aqueous solution is added to the 5% by mass brown sugar aqueous solution, and the shaking suspension (shaking condition: 100 rpm) is performed at 30 ° C. for 2 days. went. The culture solution after shaking culture was sterilized with an autoclave (conditions: 121 ° C., 15 minutes), and then impurities and residues were removed by filtration. Thereafter, purified water and phenoxyethanol were added to prepare a brown sugar fermentation broth of Kluyveromyces thermotolerans having a solid concentration of 0.1% by mass. The ethanol content was 0.01%.

<Examples 1 to 7 and Comparative Examples 1 and 2: Production of moisturizing agent>
The brown sugar fermentation broth prepared in Preparation Example 1 was mixed so that the solid content concentration was 0.09% by mass and each polyhydric alcohol shown in Table 1 was 10% by mass, and Examples 1 to 7 and Comparative Examples 1 to 2 were mixed. A humectant was produced. Moreover, the sample which mixed the purified water instead of the brown sugar fermentation liquid was also prepared.
The specific gravity was measured by the specific gravity measurement method No. 1 described in Japan Ministry of Health, Labor and Welfare: Quasi-drug raw material standard 2006 (published by Yakuji Nippo Co., Ltd.).
The refractive index was measured by the refractive index measurement method described in the Ministry of Health, Labor and Welfare: quasi-drug raw material standard 2006 (published by Yakuji Nippo Co., Ltd.).
No symbol: Quasi-drug raw material standard 2006
# 1 MERCK INDEX ELEVENTH EDITION
# 2 Chemical Handbook Basics I (The Chemical Society of Japan, revised 4th edition)
# 3 Cosmetics Handbook (Nikko Chemicals)
# 4 Chemical book

The moisturizing effect was measured by the following method.
After washing the inner part of the forearm, the measurement site (2 cm × 2 cm) was marked. It was acclimatized for 20 minutes under an air temperature of 20 ° C. and a humidity of 50%, and the moisture content was measured with Skicon200 (IBSCo. Ltd.). This value was taken as the value before coating. Thereafter, 100 μL of the sample was impregnated into a 2 cm × 2 cm tissue paper, and then placed on the measurement site and allowed to stand for 5 minutes. The tissue paper was peeled off and the sample was applied to the skin with a finger. The value obtained by measuring the moisture content with Skicon200 (IBSCo. Ltd.) 60 minutes after the completion of coating was taken as the value after 60 minutes.

The results of the moisture retention test are shown in FIGS.
S is the time when the mixed solution of brown sugar fermented liquid and polyhydric alcohol is applied, w is the time when the mixed liquid of brown sugar fermented liquid and purified water is applied, the water content after 60 minutes of application is A, and the water content before coating B.
As / Bs and Aw / Bw at this time are shown in FIG. Further, (As / Bs) / (Aw / Bw) is shown in FIG.
In Comparative Example 2 in which brown sugar fermented liquid and purified water were combined, the amount of water was lower than before application, but the brown sugar fermented liquid was combined with polyhydric alcohol having a specific gravity of 0.93 or higher at 20 ° C. In Examples 1 to 7, the water content was kept high until 60 minutes after application.
That is, by combining a sugar fermentation product from yeast of the genus Kluyveromyces with a polyhydric alcohol having a specific gravity of 0.93 or higher at 20 ° C., the moisture content is dramatically increased compared to the case where each is used alone. It was observed that the sex was improved. It was recognized that the moisture retention was significantly improved when the specific gravity of the polyhydric alcohol exceeded 1.0065.

[Prescription Example 1: Solubilized lotion]
(Ingredient) (mass%)
1. POE (40 mol) hydrogenated castor oil 0.5
2. POE (12 mol) dioleate 0.3
3. Astaxanthin 0.025
4.1,3-Butylene glycol 2.0
5. Glycerin 2.0
6). Ethanol 15.0
7). Tranexamic acid 2.0
8). Brown sugar fermentation broth of Preparation Example 1 (solid content concentration 0.1% by mass) 10.0
9. Sodium lactate 0.2
10. Methyl paraoxybenzoate 0.1
11. Purified water balance
(Production method)
A. Components 1 to 6 are mixed and dissolved.
B. Components 7 to 11 are mixed and dissolved.
C. A was added to B to obtain a skin lotion.
The skin lotion of the present Formulation Example 1 moisturized the skin, prevented the skin from drying for a long time, and was excellent in the moisturizing effect.

[Formulation Example 2: Emulsion lotion]
(Ingredient) (mass%)
1. Soybean-derived hydrogenated phospholipid 0.5
2. Cetostearyl alcohol 0.1
3. Polyoxyethylene (10 mol) cholesterol ether 0.2
4). Acetic acid-dl-α-tocopherol 0.1
5. Squalane 0.1
6). Hydroxyethyl cellulose 0.03
7). Purified water remaining amount 8. Kojic acid 2.0
9. Brown sugar fermentation broth of Preparation Example 1 (solid content concentration 0.1% by mass) 5.0
10. Disodium monohydrogen phosphate 0.1
11. Monosodium dihydrogen phosphate 0.1
12 Glycerin 3.0
13. Dipropylene glycol 2.0
14 Ethanol 7.0
15. Perfume
(Production method)
A. Ingredients 1 to 5 are heated to 75 ° C. and mixed and dissolved uniformly.

B. Ingredients

6 and 7 are heated to 75 ° C. and mixed and dissolved uniformly. Add B to A and emulsify.
D. C was cooled and ingredients 8 to 15 were added to obtain an emulsified lotion.
The lotion of the present Formulation Example 2 moisturized the skin, prevented the skin from drying for a long time, and was excellent in the moisturizing effect.

[Prescription Example 3: Latex]
(Ingredient) (mass%)
1. Polyoxyethylene (20) sorbitan monooleate 1.0
2. Sorbitan sesquioleate 0.5
3. Glyceryl trioctanoate 0.5
4). Jojoba oil 0.5
5. Squalane 0.5
6). 6. Purified water remaining amount Edetate disodium 0.1
8). Methylparaben 0.2
9. Phenoxyethanol 0.5
10. Glycerin 5.0
11. Propanediol 1.0
12 Propylene glycol 2.0
13. Sodium lactate 0.5
14. 2-O-α-D-glucosyl-L-ascorbic acid 1.0
15. Brown sugar fermentation broth of Preparation Example 1 (solid content concentration 0.1% by mass) 20.0
16. Xanthan gum 0.05
17. Purified water 10.0
18. Ethanol 3.0
19. Perfume
(Production method)
A: Swell component 16 with component 17 heated to 70 ° C.
B: Components 1 to 5 are heated and mixed at 70 ° C.
C: Components 6 to 13 are dissolved by heating at 70 ° C., then added to B and emulsified.
D: After cooling C to room temperature, ingredients 14, 15, 18 and A were added to obtain a cosmetic liquid.
The emulsion of this Formulation Example 3 moisturized the skin, prevented the skin from drying for a long time, and was excellent in the moisturizing effect.

[Formulation Example 4: Hair Nourishing]
(Ingredient) (mass%)
1. Srutianin 1.5
2. Ginkgo biloba extract 0.5
3. Dipotassium glycyrrhizinate 0.1
4). Brown sugar fermentation liquid of Preparation Example 1 (solid content concentration 0.1% by mass) 1.0
5. Glycerin 2.0
6). 6. Purified water remaining amount D-pantothenyl alcohol 0.3
8). Hinokitiol 0.02
9. Cephalanthin 0.001
10. Tocopherol acetate 0.01
11. L-Menthol 0.2
12 Polyoxyethylene hydrogenated castor oil 0.2
13. Ethanol 60
(Production method)
A. Components 1 to 6 are mixed and dissolved.
B. Components 7 to 11 are mixed and dissolved.
C. B was added to A to obtain a hair nourishing agent.
The hair nourishing agent of Prescription Example 4 moisturized the scalp and hair, prevented drying over a long period of time, and was excellent in moisturizing effect.

[Prescription Example 5: Hair Treatment]
(Ingredient) (mass%)
1. 1. Purified water remaining amount Ethanol 10.0
3. Propylene glycol 2.0
4). Sodium monohydrogen phosphate 0.03
5. Hydroxyethyl cellulose 0.01
6). Ethanol 5.0
7). Stearyltrimethylammonium chloride 0.32
8). Jojoba oil 0.01
9. Rice bran oil 0.01
10. 2-Ethylhexyl paramethoxycinnamate 0.2
11. Isopropyl myristate 0.2
12 Methyl paraoxybenzoate 0.05
13. Isostearic acid polyoxyethylene hydrogenated castor oil 0.5
14 Sodium pyrophosphate acid 0.1
15. Sorbitol 0.3
16. Brown sugar fermentation broth of Preparation Example 1 (solid content concentration 0.1% by mass) 3.0
17. Purified water 1.0

(Production method)
A. Ingredients 1 to 5 are mixed and dissolved.
B. Components 6 to 13 are mixed and dissolved.
C. Hair treatment was obtained by adding B to A and adding 14-17.
The hair treatment of Formulation Example 5 was excellent in the effect of moisturizing the scalp and hair, preventing drying over a long period of time, moistening the hair, and giving a sense of unity.

[Prescription Example 6: Ointment A]
(Compounding ingredients) (mass%)
1. Stearyl alcohol 18.0
2. Owl 20.0
3. Polyoxyethylene (20) monooleate 0.25
4). Glycerin monostearate 0.3
5. Vaseline 40.0
6). 6. Purified water remaining amount Glycerin 10.0
8.1,2-Pentanediol 2.0
9. Brown sugar fermentation broth of Preparation Example 1 (solid content concentration 0.1% by mass) 15.0

(Production method)
A. Mix 1-5 uniformly at 70 ° C.
B. Warm 6-8 to 70 ° C.
C. Add B to A and emulsify.
D. C was cooled and 9 was added to obtain an ointment.
The ointment of Formulation Example 6 moisturized the skin, prevented the skin from drying for a long time, and was excellent in the moisturizing effect.

MA KT (NITE BP-1420) strain / Classification: Lachancea (Kluyveromyces) thermotolerans / Depositary: 292-0818, Kisarazu City, Chiba Pref. (NPMD) / Contract date: September 13, 2012.

Claims

The following components (A) and (B);
(A) Sugar fermented product from yeast of the genus Kluyveromyces (B) A humectant containing a polyhydric alcohol having a specific gravity at 20 ° C. of 0.93 or more.
The humectant according to claim 1, wherein the sugar fermentation product is a sugar fermentation product derived from sugarcane.
The humectant according to claim 1 or 2, wherein the polyhydric alcohol of component (B) is a polyhydric alcohol having a specific gravity at 20 ° C of 1.01 or more.
The humectant according to any one of claims 1 to 3, wherein the polyhydric alcohol of component (B) is one or more selected from glycerin, propanediol, propylene glycol and dipropylene glycol.