WO2014181753A1 - 測定装置 - Google Patents

測定装置 Download PDF

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Publication number
WO2014181753A1
WO2014181753A1 PCT/JP2014/062086 JP2014062086W WO2014181753A1 WO 2014181753 A1 WO2014181753 A1 WO 2014181753A1 JP 2014062086 W JP2014062086 W JP 2014062086W WO 2014181753 A1 WO2014181753 A1 WO 2014181753A1
Authority
WO
WIPO (PCT)
Prior art keywords
biosensor
biological sample
light source
measurement
detection electrode
Prior art date
Application number
PCT/JP2014/062086
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
滋 関根
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to CN201480023442.6A priority Critical patent/CN105164524A/zh
Priority to JP2015515860A priority patent/JP6455425B2/ja
Priority to KR1020157023300A priority patent/KR20160006157A/ko
Publication of WO2014181753A1 publication Critical patent/WO2014181753A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes

Definitions

  • the present invention relates to a measuring apparatus for measuring the concentration of a substance to be measured in a biological sample.
  • Insulin is known as a drug that controls blood glucose levels and is administered to diabetic patients as a therapeutic agent for diabetes.
  • the need to administer insulin is determined based on the blood glucose level of the diabetic patient. For this reason, it is important for a diabetic patient to grasp a blood glucose level.
  • the blood glucose level is the glucose concentration in the blood.
  • a simple blood glucose measuring device has been developed for the purpose of allowing a diabetic patient to easily measure his blood glucose level (see Patent Documents 1 and 2).
  • the liquid crystal screen of such a measuring device is a monochrome digital liquid crystal, and when measuring in a dark place, a light source for illuminating the monochrome liquid crystal is required. Further, at the time of measurement, it is also necessary for confirmation of a position where the biosensor is inserted and confirmation of a suction path in the biosensor for sucking the biological sample. For this reason, the light source had to be lit continuously for a long time from when the apparatus was turned on until the end of measurement. Therefore, the power consumption of the measuring device is increased, and the user is forced to frequently charge or replace the battery.
  • An object of the present invention is to provide a measuring apparatus with reduced power consumption.
  • the inventors of the present invention have completed the present invention in view of the fact that the color liquid crystal display itself has sufficient brightness in the measurement apparatus incorporating the color liquid crystal display.
  • the present invention relates to a measuring apparatus in which a biosensor is detachably provided on the apparatus body.
  • the biosensor includes a suction path for sucking a biological sample, a measurement electrode for measuring the concentration of a measurement target substance in the biological sample, and a biological A detection electrode that detects completion of aspiration of the sample, and the apparatus body includes a power source, a color liquid crystal display, an insertion port into which a biosensor is inserted, and a light source that illuminates the periphery of the insertion port. It is turned on when the power is turned on, and after the biosensor is mounted on the apparatus main body, it is turned off after the biological electrode is detected by the detection electrode of the biosensor.
  • FIG. 1 is a perspective view showing an appearance of a measuring apparatus 10 according to an embodiment of the present invention.
  • the measurement device 10 includes a biosensor 11 and a device body 12.
  • the biosensor 11 When the biosensor 11 is inserted into the insertion port 13 of the apparatus main body 12, the biosensor 11 and the apparatus main body 12 are electrically connected. The biosensor 11 is replaced for each measurement.
  • the measurement target substance of the biological sample measured by the measuring device 10 is not particularly limited, and examples thereof include glucose (blood sugar), hemoglobin, glycated hemoglobin, cortisol and active ingredients of various pharmaceuticals present in blood, Examples include cortisol and amylase present in saliva.
  • glucose blood sugar
  • hemoglobin hemoglobin
  • glycated hemoglobin glycated hemoglobin
  • cortisol active ingredients of various pharmaceuticals present in blood
  • Examples include cortisol and amylase present in saliva.
  • many measuring devices for measuring blood glucose concentration (blood glucose) are widely used.
  • the biosensor 11 is generally an elongated sheet shape.
  • the biosensor 11 is attached to the apparatus main body 12 by inserting one end of the biosensor 11 in the longitudinal direction 101 into the insertion port 13 of the apparatus main body 12. Further, the biosensor 11 is removed from the apparatus main body 12 when the biosensor 11 is pulled out in the longitudinal direction 101.
  • the biosensor 11 includes a suction path 41 for sucking a biological sample, measurement electrodes 33 and 37 for measuring the concentration of a measurement target substance of the biological sample, and a detection electrode 39 for detecting completion of the suction of the biological sample.
  • This configuration is a very common configuration in the field of biosensors.
  • the suction path 41 has a configuration in which a biological sample reaches from the outside of the biosensor 11 to the detection electrode 39 via the measurement electrodes 33 and 37.
  • the detection electrode 39 is an electrode for electrically detecting the presence or absence of a biological sample reaching the detection electrode 39. Once the presence of the biological sample is detected by the detection electrode 39, the user no longer needs to confirm the position of the insertion port 13 in the measuring apparatus or the position of the suction path 41 in the biosensor 11 for sucking the biological sample.
  • the types of electrodes in the measurement electrodes 33 and 37 and the detection electrode 39, reagents used for the measurement electrodes 33 and 37, and the like can be appropriately selected by those skilled in the art depending on the substance to be measured.
  • the electrode material can be gold, platinum, silver, carbon, etc.
  • the reagents used in the measurement system are enzymes such as glucose dehydrogenase and glucose oxidase, and An electron mediator such as potassium ferricyan and hexaaminoruthenium is preferably selected.
  • the apparatus main body 12 is an electronic apparatus in which an electronic component is accommodated in a housing 50.
  • a color liquid crystal display 51 On the front side of the housing 50, a color liquid crystal display 51, a power button 52, operation buttons 53, 54 and 55, an insertion port 13 for inserting the biosensor 11, and a light source 14 provided around the insertion port 13 are arranged.
  • the housing 50 contains a power source, voltage application means, current measurement means, a control board for controlling these, and the like.
  • the control board operates a program stored in the ROM in advance. Further, the control board calculates the concentration of the measurement target in the biological sample from the current value flowing through the biosensor 11 in response to a predetermined potential. The calculated concentration to be measured in the biological sample is displayed on the color liquid crystal display 51.
  • the color liquid crystal display 51 displays the state of the apparatus main body 12, measurement results, error display, and the like.
  • the power button 52 is for inputting the power of the apparatus main body 12.
  • the operation buttons 53, 54, and 55 are for generating corresponding commands based on user operations.
  • the color liquid crystal display 51 is used as a display screen, the backlight can display with sufficient brightness even in a dark place, and a separate light source for illuminating the color liquid crystal display 51 is necessary. Absent.
  • the insertion port 13 is provided with terminals that are electrically connected to the measurement electrodes 33 and 37 and the detection electrode 39 of the biosensor 11 (not shown in the figure).
  • the shape of the insertion opening 13 is not particularly limited. As shown in FIG. 1, the shape of the insertion opening 13 is notched on the lower side when the apparatus body 12 is viewed from the front side where the color liquid crystal display 51 is disposed. It is preferable that the biosensor 11 inserted into the insertion port 13 can be stably fixed. By providing the light source 14 along the notch-shaped peripheral edge that is the insertion opening 13, the position of the insertion opening 13 is more conspicuous and the apparatus main body 12 is excellent in design and beauty.
  • the light source 14 is a means for illuminating the periphery of the insertion port 13.
  • the light source 14 is not particularly limited as long as it is used industrially, and an incandescent bulb or LED can be mainly used. However, the apparatus main body 12 does not generate heat and the power consumption is small. From the viewpoint, an LED is preferable. Power is supplied to the light source 14 from a power source. The light source 14 is turned on and off by the control board.
  • the control board When the power button 52 is pressed, the control board turns on the power of the measuring apparatus 10 and turns on the light source 14. When the light source 14 is turned on, the user can easily recognize the insertion port 13 into which the biosensor 11 is to be inserted.
  • the detection electrode 39 detects the biological sample.
  • the control board turns off the light source 14. Since the light source 14 is turned off, only the color liquid crystal display 51 is in a bright state, so that the color liquid crystal display 51 on which the measurement result is displayed can be focused.
  • the translucent resin is not particularly limited as long as it is an industrially used resin, and for example, polypropylene, polycarbonate, acrylic resin, epoxy resin, and the like can be used.
  • the degree of light intensity relaxation of the light source 14 is adjusted by the intensity of the light source 14 itself and the type and thickness of the translucent resin.
  • an LED is generally composed of a semiconductor, an electrode, and a sealing material.
  • the sealing material is a member for preventing contamination of the semiconductor and the electrode, and is generally formed of a transparent resin.
  • the present invention is not limited to a general LED, that is, an embodiment in which the periphery of an LED in which a sealing material is formed of a transparent resin is protected by a semi-transparent resin, but also by adopting a translucent resin as a sealing material. An aspect in which a part of the mouth 13 is formed may be used.
  • the usage method of the measuring apparatus 10 is demonstrated by taking the case where the blood glucose level (blood glucose level) is measured using the measuring apparatus 10 as an example.
  • the user presses the power button 52 of the apparatus body 12 to turn on the power. Then, the light source 14 in the insertion port 13 of the apparatus main body 12 is turned on, and the position of the insertion port 13 in the apparatus main body 12 can be easily grasped even in a dark place. Note that a startup screen is displayed on the color liquid crystal display 51.
  • the user inserts the biosensor 11 into the insertion port 13 of the apparatus main body 12.
  • the user causes the suction path 41 of the biosensor 11 to suck a small amount of blood collected from a finger or the like without dilution.
  • the conductive state between the working electrode or the counter electrode as the measurement electrodes 33 and 37 and the detection electrode 39 changes.
  • the control board determines that blood is introduced into the biosensor 11 due to the change in the conductive state, and turns off the light source 14 at the insertion port 13. This is because it is no longer necessary for the user to grasp the position of the insertion port 13 in the apparatus main body 12 and the position of the suction path 41 of the biosensor 11 attached to the insertion port 13. This is because illuminating with a waste of power.
  • the voltage application means applies a predetermined potential to the measurement electrodes 33 and 37. Thereby, an oxidation response current corresponding to the blood glucose concentration flows between the measurement electrodes 33 and 37. Based on the oxidation response current flowing between the measurement electrodes 33 and 37 in this way, the current measurement means calculates the blood glucose concentration and displays the result on the color liquid crystal display 51.
  • the control board turns off the power of the apparatus main body 12. To do.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Human Computer Interaction (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
PCT/JP2014/062086 2013-05-10 2014-05-01 測定装置 WO2014181753A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201480023442.6A CN105164524A (zh) 2013-05-10 2014-05-01 测量装置
JP2015515860A JP6455425B2 (ja) 2013-05-10 2014-05-01 測定装置
KR1020157023300A KR20160006157A (ko) 2013-05-10 2014-05-01 측정장치

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-099998 2013-05-10
JP2013099998 2013-05-10

Publications (1)

Publication Number Publication Date
WO2014181753A1 true WO2014181753A1 (ja) 2014-11-13

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ID=51867234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/062086 WO2014181753A1 (ja) 2013-05-10 2014-05-01 測定装置

Country Status (4)

Country Link
JP (1) JP6455425B2 (ko)
KR (1) KR20160006157A (ko)
CN (1) CN105164524A (ko)
WO (1) WO2014181753A1 (ko)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021001208A1 (en) 2019-07-04 2021-01-07 Mint Diagnostics Ltd Saliva testing
WO2021185695A1 (en) 2020-03-19 2021-09-23 Mint Diagnostics Ltd Microfluidic point-of-care assay
WO2023187384A1 (en) 2022-04-01 2023-10-05 Mint Diagnostics Ltd Microfluidic collection and test
JP7362119B2 (ja) 2020-02-03 2023-10-17 国立研究開発法人物質・材料研究機構 測定装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11235196A (ja) * 1998-02-20 1999-08-31 Kdk Corp バイオセンサシステム
JP2000131263A (ja) * 1998-10-20 2000-05-12 Kdk Corp レンズ付き液体試料測定装置
JP2003512866A (ja) * 1999-07-28 2003-04-08 アボット・ラボラトリーズ 発光グルコースモニタ装置
WO2008035697A1 (fr) * 2006-09-19 2008-03-27 Panasonic Corporation Capteur sanguin et instrument d'examen du sang incluant ledit capteur
JP2010181219A (ja) * 2009-02-04 2010-08-19 Panasonic Corp 測定装置及びそれに用いる点検用センサ、並びに測定装置の点検方法
JP2011502263A (ja) * 2007-10-31 2011-01-20 ニプロ ダイアグナスティックス，インコーポレーテッド 液体サンプル中の被分析物の濃度を測定するテストストリップ及びシステム
JP2011237408A (ja) * 2010-04-14 2011-11-24 Arkray Inc 生体情報測定装置、生体情報測定装置における照明方法、および生体情報測定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071028B2 (en) * 2003-06-12 2011-12-06 Abbott Diabetes Care Inc. Method and apparatus for providing power management in data communication systems
JP2011137767A (ja) * 2009-12-29 2011-07-14 Nipro Corp バイオセンサ、及び当該バイオセンサを有する測定装置
JP5509969B2 (ja) 2010-03-25 2014-06-04 ニプロ株式会社 測定装置及び測定方法
JP5625555B2 (ja) 2010-07-06 2014-11-19 ニプロ株式会社 血中グルコース濃度測定装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11235196A (ja) * 1998-02-20 1999-08-31 Kdk Corp バイオセンサシステム
JP2000131263A (ja) * 1998-10-20 2000-05-12 Kdk Corp レンズ付き液体試料測定装置
JP2003512866A (ja) * 1999-07-28 2003-04-08 アボット・ラボラトリーズ 発光グルコースモニタ装置
WO2008035697A1 (fr) * 2006-09-19 2008-03-27 Panasonic Corporation Capteur sanguin et instrument d'examen du sang incluant ledit capteur
JP2011502263A (ja) * 2007-10-31 2011-01-20 ニプロ ダイアグナスティックス，インコーポレーテッド 液体サンプル中の被分析物の濃度を測定するテストストリップ及びシステム
JP2010181219A (ja) * 2009-02-04 2010-08-19 Panasonic Corp 測定装置及びそれに用いる点検用センサ、並びに測定装置の点検方法
JP2011237408A (ja) * 2010-04-14 2011-11-24 Arkray Inc 生体情報測定装置、生体情報測定装置における照明方法、および生体情報測定方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021001208A1 (en) 2019-07-04 2021-01-07 Mint Diagnostics Ltd Saliva testing
JP7362119B2 (ja) 2020-02-03 2023-10-17 国立研究開発法人物質・材料研究機構 測定装置
WO2021185695A1 (en) 2020-03-19 2021-09-23 Mint Diagnostics Ltd Microfluidic point-of-care assay
WO2023187384A1 (en) 2022-04-01 2023-10-05 Mint Diagnostics Ltd Microfluidic collection and test

Also Published As

Publication number Publication date
KR20160006157A (ko) 2016-01-18
CN105164524A (zh) 2015-12-16
JP6455425B2 (ja) 2019-01-23
JPWO2014181753A1 (ja) 2017-02-23

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