WO2014148289A1 - 生体加熱器具及び制御装置 - Google Patents
生体加熱器具及び制御装置 Download PDFInfo
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- WO2014148289A1 WO2014148289A1 PCT/JP2014/056129 JP2014056129W WO2014148289A1 WO 2014148289 A1 WO2014148289 A1 WO 2014148289A1 JP 2014056129 W JP2014056129 W JP 2014056129W WO 2014148289 A1 WO2014148289 A1 WO 2014148289A1
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- needle
- living body
- body heating
- heater
- inner needle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
- A61B18/082—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00482—Digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00595—Cauterization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
Definitions
- the present invention relates to a living body heating instrument and a control device therefor that punctures or inserts a needle part into an affected part of a living body and heats the affected part.
- Patent Document 1 a needle part with a built-in heater is punctured or inserted into an affected part, and the affected part is cauterized by being heated by the heater.
- stage 3 and stage 4 such as lung cancer and pancreatic cancer
- a minimally invasive treatment is desired even for a surgical treatment.
- An object of the present invention is to provide a minimally invasive living body heating apparatus that can puncture or insert into an affected part and reliably heat the affected part.
- Another object of the present invention is to provide a control device for controlling the living body heating instrument.
- the living body heating apparatus which is punctured or inserted into an affected part in a living body and heats the affected part, has an inner needle and an inner needle inserted from a needle base side opening into a needle tip side. And an outer needle having a hollow portion.
- the inner needle has biocompatibility and thermal conductivity, and has a built-in heater.
- the inner needle may further incorporate a temperature detection element. Further, a temperature detection element may be provided on the outer surface of the outer needle so that the temperature of the affected part to be heated can be measured more accurately.
- the outer needle can be configured as follows, for example. That is, the hollow part of the outer needle can be a through hole in which the needle tip and the needle base of the outer needle are opened or a hole part in which only the needle base is opened. Further, on the outer surface of the outer needle, a heat insulating layer may be provided in a region excluding the region where the affected part is heated, so that portions other than the affected part are not heated.
- the control device for controlling the living body heating appliance as described above includes a transmission / reception unit that performs transmission / reception with the living body heating device, and a controller that controls the temperature and / or heating time of the heater of the living body heating device that performs transmission / reception with the transmission / reception unit. .
- the controller can also independently control the heaters of a plurality of biological heating devices. Further, the controller may control the heater based on temperature data from the temperature detection element.
- a living body heating instrument is inserted into an outer needle with an inner needle having a built-in heater, and the living body is punctured or inserted until it reaches the affected area, the heater generates heat, and the affected area is cauterized.
- the living body heating device may be removed, but further, after the cauterization, with the living body heating device being punctured or inserted, the inner needle is withdrawn from the outer needle, and the medicine is passed through the outer needle. Can be injected directly into the affected area.
- the temperature detection element is provided in the inner needle or on the outer surface of the outer needle, the temperature data is fed back to the control device, so that more precise temperature control of the heater can be performed.
- the heaters of the individual living body heating devices are controlled independently, so that the heaters can be finely adjusted according to the state of the position where the needle is punctured or inserted. The temperature can be adjusted.
- FIG. 1 is an exploded perspective view of a living body heating apparatus to which the present invention is applied.
- FIG. 2 is a perspective view of a living body heating device to which the present invention is applied.
- FIG. 3 is a diagram conceptually showing ablation therapy while showing a living body heating instrument and a control device to which the present invention is applied.
- FIG. 4 is a diagram conceptually showing a therapy in which a medicine is directly injected into an affected part cauterized.
- FIG. 5 is a modification of the living body heating device to which the present invention is applied, and is a cross-sectional view of a main part of the living body heating device in which the temperature detection element is provided on the outer surface of the outer needle.
- FIG. 1 is an exploded perspective view of a living body heating apparatus to which the present invention is applied.
- FIG. 2 is a perspective view of a living body heating device to which the present invention is applied.
- FIG. 3 is a diagram conceptually showing ablation therapy while showing a living body heating instrument and a
- FIG. 6 is a modification of the living body heating device to which the present invention is applied, and is a cross-sectional view of a main part of the living body heating device in which a heat insulating layer is provided on the outer surface of the outer needle.
- FIG. 7 is a modification of the living body heating device to which the present invention is applied, and is a cross-sectional view of a main part of the living body heating device in which a temperature detection element and a heat insulating layer are provided on the outer surface of the outer needle.
- the living body heating instrument 10 includes an inner needle 11 and an outer needle 21 into which the inner needle 11 is inserted.
- the living body heating instrument 10 is inserted into a diseased part 1 that has become cancerous, such as a lung or pancreas, in the living body, with the inner needle 11 inserted into the outer needle 21.
- stainless steel is used as the metal material having excellent thermal conductivity in the needle portions 11a and 21a of the inner needle 11 and the outer needle 21 while having biocompatibility.
- the inner needle 11 has, for example, a total length of about 150 mm to 200 mm, and a diameter of the needle portion 11a of about 0.3 mm to about 0.9 mm, preferably about 0.45.
- the needle portion 11 a of the inner needle 11 has a hollow portion 12, and a heater 13 is disposed in the hollow portion 12 on the needle tip side.
- the heater 13 has a continuous thread shape with a thickness of 0.5 mm or less, and has flexibility.
- a thread-like heater 13 is inserted into the hollow portion 12 of the needle portion 11a from the opening on the needle base side, and is disposed on the needle tip side where the affected portion 1 is cauterized.
- a temperature detection element 14 such as a thermocouple or a Peltier element is provided in the hollow portion 12 to detect the temperature of the needle tip side of the needle portion 11 a, and the needle portion 11 a is detected by the control device 30.
- the temperature may be controlled.
- a thermocouple is used for the temperature detection element 14, it is insulated from the heater 13 with an insulator such as a polyimide tube and disposed in the hollow portion 12.
- one or a plurality of heaters 13 may be disposed in the hollow portion 12 of the needle portion 11a.
- the heater 13 and the temperature detecting element 14 may be arranged side by side in the longitudinal direction of the inner needle 11 or may be arranged side by side in the radial direction.
- the temperature detection element 14 can detect the temperature on the heater 13.
- the temperature detection element 14 can be protected from the heat of the heater 13 by partitioning the heater 13 and the temperature detection element 14 with a heat insulating material or the like. Further, the heater 13 may be disposed at a place other than the distal end portion of the inner needle 11 according to the purpose of treatment.
- the cutting edge of the inner needle 11 is closed with a hollow portion 12 with biocompatible resin or the like.
- the needle base portion 15 of the inner needle 11 is formed of a synthetic resin material such as polymethylpentene or polypropylene having electrical insulation and biocompatibility, or a metal material obtained by plating a brass with Ni or the like.
- the needle base portion 15 of the inner needle 11 is formed thicker than the needle portion 11a and serves as an inner needle operation portion that facilitates the work of pulling the inner needle 11 from the outer needle 21 with a medical instrument such as a probe or by hand.
- the portion 12 is closed so that moisture does not enter.
- the cutting edge of the inner needle 11 is cut and sharpened so that the blade surface is an inclined surface here.
- the shape of the blade surface is not limited to this.
- the outer needle 21 into which the inner needle 11 is inserted is formed to have substantially the same length, that is, about 150 mm to 200 mm in length so that the cutting edge is aligned with the cutting edge of the inner needle 11 when the inner needle 11 is inserted.
- the needle portion 21a has a cylindrical shape, and the thickness thereof is, for example, about 18G (outer diameter 1.2 mm / inner diameter 0.94 mm) to 23G (outer diameter 0.65 mm / inner diameter 0.4 mm).
- the hollow portion 22 of the needle portion 21a of the outer needle 21 has a blade opening 23 formed at the tip, and a needle base opening 24 formed in the needle base, forming a through hole.
- the needle base 25 of the outer needle 21 is formed of a synthetic resin material such as polymethylpentene or polypropylene having electrical insulation properties or biocompatibility, or a metal material obtained by plating brass or the like with Ni or the like.
- the needle base portion 25 of the outer needle 21 is formed thicker than the needle portion 21a, and serves as an outer needle operation portion that facilitates the operation of puncturing or inserting the affected portion with a medical instrument such as a probe or the hand, or withdrawing from the affected portion 1.
- the cutting edge of the outer needle 21 is cut so that the cutting surface is an inclined surface, and is sharpened.
- the shape of the blade surface is not limited to this.
- the needle base 15 of the inner needle 11 is fitted to the needle base 25 of the outer needle 21.
- a positioning convex portion 16 is formed on the needle base portion 15 of the inner needle 11, and a positioning concave portion 26 is formed on the needle base portion 25 of the outer needle 21.
- the positioning convex portion 16 of the needle base portion 15 of the inner needle 11 engages with the positioning concave portion 26 of the needle base portion 25 of the outer needle 21.
- rotation is stopped and positioning in the circumferential direction is performed.
- the inclined blade surface of the inner needle 11 and the inclined blade surface of the outer needle 21 coincide with each other to form a flush surface.
- the positioning convex portion may be formed on the needle base portion 25 of the outer needle 21, and the positioning concave portion may be formed on the needle base portion 15 of the inner needle 11.
- a scale 27 with a predetermined interval is formed so that it can be used as a guide when puncturing or inserting into the affected area 1, and the index member 28 is slidably inserted. Yes.
- the user can use the indicator member 28 along the needle portion 21a of the outer needle 21 as a guideline for recognizing the puncture or insertion depth in relation to the scale 27.
- the inner needle 11 is inserted into the hollow portion 22 of the outer needle 21, and the needle base portion 15 of the inner needle 11 is inserted into the needle base portion 25 of the outer needle 21.
- the positioning convex portion 16 is engaged with the positioning concave portion 26 and positioned in the circumferential direction. Further, the inclined blade surface of the inner blade edge coincides with the inclined blade surface of the outer needle. It is an inclined surface.
- the plug 18 of the connection cord 17 led out from the needle base portion 15 of the inner needle 11 is connected to the control device 30 with the inner needle 11 being combined with the outer needle 21.
- the control device 30 includes a terminal unit 31 to which plugs 18 of a plurality of living body heating devices 10 serving as transmission / reception units are connected, a controller 32 that controls the plurality of living body heating devices 10, and an operation signal that operates the living body heating device 10. Are input to the controller 32, and a display unit 34 for displaying the operation status.
- the operation unit 33 is provided with a switch configured by a dial switch, a slide switch, or the like according to the number of the terminal units 31, and the temperature of the heater 13 of each living body heating instrument 10 is independently set using each switch. Control. For example, the user can adjust the temperature of the heater 13 of each living body heating instrument 10 by operating the operation unit 33 while viewing the temperature of the heater 13 of each living body heating apparatus 10 displayed on the display unit 34. .
- the living body heating device 10 controls the heater 13 to, for example, about 60 ° C. so that the amount of heat that the protein irreversibly heat-denaturates is given to the cancer cells, thereby minimizing the damage given to the healthy cells. Can be cauterized.
- the temperature detecting element 14 is provided in the needle portion 11a
- temperature data is supplied from the temperature detecting element to the controller 32, and the controller 32 controls the heater 13 so that the heating temperature is constant. For example, even if there is a blood flow at the position where the living body heating device 10 is punctured or inserted, and there is a partial temperature loss, the temperature of the heater 13 of each living body heating device 10 can be adjusted. It can be heated to the desired temperature.
- the controller 32 may incorporate a timer and control to turn off the heater 13 when the cauterization time set by the operation unit 33 is reached.
- the exchange of the control data of the heater 13 and the temperature data of the heater 13 between the living body heating apparatus 10 and the control device 30 may be wired as described above or may be wireless.
- the power supply to the heater 13 may be supplied from a control device 30 in a wired manner, or may be supplied from a primary battery or a secondary battery provided in the living body heating instrument 10.
- the affected part 1 that has become cancerous such as a lung or pancreas in a living body, which is a puncture target, is specifically observed, and the puncture route, the ablation temperature of the affected part 1, the ablation time, etc.
- the living body heating instrument 10 is taken out from the container, and the needle base 25 of the outer needle 21 is fixed to a medical instrument such as a probe, and the plug 18 of the connection cord 17 led out from the needle base 15 of the inner needle 11 is connected to the control device 30. Connect to terminal portion 31.
- the living body heating device 10 Prior to the puncture or insertion into the affected area 1, the living body heating device 10 sets a standard for the depth of puncture or insertion using the index member 28 and the scale 27 of the outer needle 21. Next, puncture or insertion is performed in the affected area 1 where the needle tip is specified while confirming the needle tip echo of the ultrasonic image of the living body heating instrument 10, the X-ray fluoroscopy, or the CT guide direction and depth. The affected area 1 is punctured or inserted with the inner needle 11 inserted into the outer needle 21. When only the outer needle 21 is punctured or inserted, it may be difficult to puncture or insert at the target bending position. However, since the inner needle 11 is inserted into the outer needle 21 and it is difficult to bend, The needle tip of the instrument 10 can accurately reach the affected area 1.
- the outer needle 21 is used to puncture or insert the affected area 1, and then the inner needle 11 is inserted into the outer needle 21. You may make it do.
- the affected part 1 is cauterized for a predetermined time by operating the operation unit 33 of the control device 30 to heat the heater 13 so that the predetermined cauterization temperature is reached and the needle tip portion of the outer needle 21 is heated.
- the controller 32 can independently control the heater 13 of each living body heating instrument 10 based on the temperature data fed back from the temperature detection element 14. Therefore, for example, even if blood flow exists at the position where the living body heating instrument 10 is punctured or inserted, and there is a partial temperature loss, the entire affected area 1 can be heated to a desired temperature.
- the living body heating instrument 10 can perform cauterization of the affected part 1 simply by puncturing or inserting the affected part 1 in the deep part of the living body, and can realize a less invasive ablation therapy for the patient. it can.
- the living body heating instrument 10 may be removed from the affected area 1 as it is, but here, after the cauterization, the inner needle 11 is pulled out from the living body heating instrument 10 punctured in the affected area 1. .
- a tube 41 such as a drip is connected to the needle base opening 24 of the outer needle 21, passes through the hollow part 22 of the outer needle 21, and the affected part 1 from the blade edge opening 23.
- immunotherapy includes dendritic cell vaccine therapy.
- an immunotherapy can be performed by injecting a drug 40 such as a vaccine containing dendritic cells into the cauterized affected part 1.
- a drug 40 such as a vaccine containing dendritic cells
- poured from the needle base 25 of the outer needle 21 it is not limited to the above example, Various things can be used according to a patient's treatment policy, for example, an anticancer agent etc. It may be.
- ablation therapy for the affected area 1 and therapy for directly injecting a drug into the affected area can be performed continuously, and a minimally invasive treatment can be realized for the patient.
- the blade opening 23 of the outer needle 21 is blocked because it is not necessary to inject the medicine 40 into the cauterized affected part 1, and the hollow part 22 is The hole part which only the needle base opening part 24 opened may be sufficient.
- the living body heating instrument 10 is punctured or inserted into the living body until it reaches the affected area 1 in a state where the inner needle 11 incorporating the heater 13 is combined with the outer needle 21, and the heater 13 generates heat. Then, the affected area 1 is cauterized.
- the living body heating device 1 may be removed, but the inner needle 11 is pulled out from the outer needle 21 with the living body heating device 1 being punctured or inserted, and the medicine is cauterized through the outer needle 21. It can be directly injected into the affected area 1. In this way, the living body heating instrument 10 only needs to be punctured or inserted so as to reach the affected area 1 without performing a laparotomy or the like, so that it is possible to realize minimally invasiveness. In addition, there is no risk of exposure as in radiotherapy, and patients do not feel pain or numbness as in radiofrequency therapy.
- the temperature detection element 14 is built in the inner needle 11
- the temperature data is fed back to the control device 30, whereby finer temperature control of the heater 13 can be performed.
- the heater 13 of each living body heating device 10 is controlled independently, so that the living body heating device 10 is finely tuned according to the state of the puncture or insertion. The temperature of the heater 13 can be adjusted.
- the temperature detection element 14 may be provided on the outer surface of the outer needle 21.
- a temperature detection element 14 is provided on the outer surface of the outer needle 21 at a position near the heater 13 when the inner needle 11 is inserted.
- the temperature detection element 14 is fixed to the outer surface of the outer needle 21 with a biocompatible adhesive or resin.
- the temperature detection element 14 when the temperature detection element 14 is provided on the outer surface of the outer needle 21 and in the vicinity of the heater 13, the temperature detection element 14 is in contact with the heated affected area 1, so that the affected area is more accurately detected. 1 heating temperature can be measured.
- the needle base 15 can be reduced in size, and the operability of the inner needle 11 can be improved.
- a connection cord extending from the temperature detection element 14 that connects the temperature detection element 14 and the control device 30 is derived from the needle base 25 of the outer needle 21.
- the temperature detection element 14 and the connection cord are covered with a biocompatible material.
- tip part of the inner needle 11 is obstruct
- the inner needle 11 and the outer needle 21 are often formed of a biocompatible metal material such as stainless steel, and are excellent in thermal conductivity. Therefore, for example, even when the heater 13 is built in the distal end portion of the inner needle 11, the temperature rises to a region other than the distal end portion of the outer needle 21 and to the middle due to heat conduction. In this case, the area other than the affected area 1 may be heated more than necessary. In general, in the living body heating device 10, the heating region that is punctured or inserted into the affected area 1 and cauterizes the affected area 1 is often determined only at the distal end or as ⁇ mm from the distal end. Therefore, as shown in FIG.
- the outer surface of the outer needle 21 may be provided with a heat insulating layer 29 on the outer surface of the outer needle 21 in a region excluding the region 29 a for heating the affected part 1.
- a heat insulating layer 29 on the outer surface of the outer needle 21 in a region excluding the region 29 a for heating the affected part 1.
- biocompatible carbon fiber, ceramic, resin or the like can be used for the heat insulating layer 29.
- the distal end portion of the outer needle 21 is used as a heating region 29a, and the heat insulating layer 29 is provided on the needle base side from the distal end portion, and the outer surface of the outer needle 21 is exposed in the heating region 29a.
- the heating area 29a can be heated to a heating temperature at which the affected area 1 is cauterized, the temperature rise in other areas can be suppressed, and the area other than the affected area 1 can be prevented from being heated more than necessary. can do.
- region 29a is decided by relations, such as a use, For example, it is good also not as a front-end
- the temperature detection element 14 is provided on the outer surface of the outer needle 21, and the heat insulating layer 29 is provided on the outer surface of the outer needle 21.
- the temperature of the affected part 1 to be cauterized can be accurately measured by the temperature detecting element 14, and a part other than the affected part 1 is heated in a region other than the heating region 29a. Can be prevented.
- the living body heating device 10 can be used for various cancer treatments such as uterine cancer and cervical cancer other than the above-described lung cancer and pancreatic cancer. It can also be used to heat affected areas other than humans.
- 1 affected part 10 living body heating instrument, 11 inner needle, 11a needle part, 12 hollow part, 12a occlusion member, 13 heater, 14 temperature detection element, 15 needle base, 16 positioning convex part, 17 connection cord, 18 plug, 21 outside Needle, 21a needle part, 22 hollow part, 23 cutting edge opening part, 24 needle base opening part, 25 needle base part, 26 positioning concave part, 27 scale, 28 index member, 29 heat insulation layer, 29a heating area, 30 control device, 31 terminal Part, 32 controller, 33 operation part, 34 display part, 40 drugs, 41 tube
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Abstract
Description
Claims (7)
- 生体内の患部に穿刺又は挿入され患部を加熱する生体加熱器具において、
内針と、
上記内針が針基側の開口から針先側に挿入される中空部を有する外針とを備え、
上記内針は、生体適合性及び熱伝導性を有し、ヒータが内蔵されている生態生体加熱器具。 - 上記内針の内部又は上記外針の外面には、更に、温度検出素子が設けられている請求項1記載の生体加熱器具。
- 上記外針の外面には、上記患部の加熱領域を除く領域に、断熱層が設けられている請求項1又は2の何れかに記載の生体加熱器具。
- 上記中空部は、上記外針の針先と針基が開口した貫通孔又は針基のみが開口した孔部である請求項1記載の生体加熱器具。
- 生体内の患部に穿刺又は挿入され患部を加熱する生体加熱器具の制御装置であって、
上記生体加熱器具は、内針と、上記内針が針基側の開口から針先側に挿入される中空の外針とを有し、上記内針が生体適合性及び熱伝導性を有し、ヒータが内蔵されており、
上記制御装置は、上記生体加熱器具と送受信を行う送受信部と、
上記送受信部と送受信を行う生体加熱器具のヒータの温度及び/又は加熱時間を制御するコントローラと
を備える制御装置。 - 上記生体加熱器具の内針の内部又は外針の外面には、更に、温度検出素子が設けられており、
上記コントローラは、上記温度検出素子からの温度データに基づいて上記ヒータを制御する請求項5記載の制御装置。 - 上記コントローラは、複数の生体加熱器具のヒータを独立して制御する請求項5又は請求項6記載の制御装置。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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EP14767430.3A EP2977032B1 (en) | 2013-03-22 | 2014-03-10 | Living body heating instrument and controller |
JP2015506703A JP6116666B2 (ja) | 2013-03-22 | 2014-03-10 | 生体加熱器具及び制御装置 |
US14/778,710 US10321947B2 (en) | 2013-03-22 | 2014-03-10 | Living body heating instrument and control device |
HK16108878.2A HK1220603A1 (zh) | 2013-03-22 | 2016-07-25 | 活體加熱儀器和控制器 |
Applications Claiming Priority (2)
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JP2013-059308 | 2013-03-22 | ||
JP2013059308 | 2013-03-22 |
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US (1) | US10321947B2 (ja) |
EP (1) | EP2977032B1 (ja) |
JP (1) | JP6116666B2 (ja) |
HK (1) | HK1220603A1 (ja) |
WO (1) | WO2014148289A1 (ja) |
Cited By (3)
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JP2016101360A (ja) * | 2014-11-28 | 2016-06-02 | 株式会社アドメテック | ガイドワイヤ及び制御装置 |
JP2020032068A (ja) * | 2018-08-31 | 2020-03-05 | 株式会社アドメテック | 内視鏡下癌治療システム |
JP2022078544A (ja) * | 2020-11-13 | 2022-05-25 | 諸見里 和子 | 点滴注射キット |
Families Citing this family (1)
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CN115886988B (zh) * | 2023-02-17 | 2023-05-12 | 北京北琪医疗科技股份有限公司 | 一种内热针与射频电极结合的装置 |
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CN201719369U (zh) * | 2010-03-29 | 2011-01-26 | 韩俊峰 | 逆向温控组合探针式肿瘤热疗仪 |
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JP2016101360A (ja) * | 2014-11-28 | 2016-06-02 | 株式会社アドメテック | ガイドワイヤ及び制御装置 |
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JP2022078544A (ja) * | 2020-11-13 | 2022-05-25 | 諸見里 和子 | 点滴注射キット |
Also Published As
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EP2977032A4 (en) | 2016-12-14 |
HK1220603A1 (zh) | 2017-05-12 |
JP6116666B2 (ja) | 2017-05-10 |
EP2977032B1 (en) | 2018-11-14 |
US20160051312A1 (en) | 2016-02-25 |
JPWO2014148289A1 (ja) | 2017-02-16 |
US10321947B2 (en) | 2019-06-18 |
EP2977032A1 (en) | 2016-01-27 |
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