WO2014139282A1 - 一种治疗生殖系统癌症的药物组合及其制备方法 - Google Patents
一种治疗生殖系统癌症的药物组合及其制备方法 Download PDFInfo
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- WO2014139282A1 WO2014139282A1 PCT/CN2013/084813 CN2013084813W WO2014139282A1 WO 2014139282 A1 WO2014139282 A1 WO 2014139282A1 CN 2013084813 W CN2013084813 W CN 2013084813W WO 2014139282 A1 WO2014139282 A1 WO 2014139282A1
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Definitions
- the present invention is in the field of health care, and is a combination of drugs for preventing and treating cancer of the reproductive system, and the scope of application is: breast hyperplasia, breast cancer, liver calculi, liver cirrhosis, liver cancer, uterine fibroids, endometrial cancer, ovary Cancer, benign prostatic hyperplasia, prostate cancer and other diseases that belong to the reproductive system can also prevent and treat gastric ulcers and stomach cancer.
- the invention relates to a medicine combination for treating and preventing reproductive system cancer using Chinese herbal medicine as a raw material medicine and a preparation method thereof.
- BACKGROUND OF THE INVENTION Cancer is the leading cause of death in humans. According to WHO estimates, 84 million people will die of cancer between 2005 and 2015 without intervention. In 2004, the number of cancer deaths reached 7.4 million (about 13% of all deaths. More than 70% of cancer deaths occur in low- and middle-income countries. Cancer deaths worldwide are expected to continue to increase, with an estimated 12 million in 2030. Died of cancer.
- the technical problem to be solved by the present invention is to overcome the deficiencies of the above methods for treating cancer, and to provide a combination of drugs for treating cancer of the reproductive system with remarkable effect, cost, and side effects.
- the reproductive system mainly belongs to the liver, and belongs to the spleen and kidney.
- Modern medicine has proved that the establishment of menstrual cycle in normal women depends on the neuroendocrine regulation between the hypothalamic-pituitary-ovarian axis and the cyclical response of the endometrium to changes in sex hormones, which regulate the action of sex hormones.
- I have also solved the liver disease mainly in the early stage of the liver, and the spleen mainly reflects the liver and spleen lesions.
- the principle of traditional Chinese medicine for the treatment of reproductive system diseases is "salt the liver and strengthen the spleen".
- the so-called “salt liver and spleen” means to clear the blood vessels and supplement the nutrition; eliminate edema and enhance the functions of the liver, spleen and pancreas.
- the representative party is "Yaoyao Pill” (composition: licorice, angelica, medlar, white peony, atractylodes, Bupleurum), "Yaoyao Pill” is mainly used in early breast hyperplasia, irregular menstruation and other diseases.
- Fangzhong Angelica and Radix Paeoniae Alba are used to clear the blood circulation of the liver and spleen, and to promote blood circulation and blood supply.
- Atractylodes macrocephala and aphid are used to eliminate edema in liver and spleen cells.
- the chemical constituents of Atractylodes lancea L. contain volatile oil, which has the effect of inhibiting mold; Hu acts on the virus in the liver blood; licorice is an auxiliary drug, which plays a role in regulating and regulating. From the role of these six-flavor drug substance, the effect of its action is weak and can not be treated.
- “Bupleurum” is mainly used to treat viral infections. It is contraindicated when "hepatic wind is moving", that is, it cannot be used when cancer occurs.
- the liver is derived from the hepatic portal vein, when the mold and virus infect the hepatic portal vein, it is easy to block the portal vein, causing portal hypertension, resulting in many varicose veins. P is further invaded by mold.
- the portal vein is blocked, the anastomosis between the portal vein and the vena cava gradually expands to form a collateral circulation, which causes the portal vein to circulate into the vena cava and into the heart.
- the main collateral circulation is: 1, the lower esophageal vein and gastric coronary varices, which is the cause of major bleeding in the digestive tract. 2, abdominal wall and umbilical veins around the umbilical cord. 3, iliac vein varicose veins, this is the cause of bleeding.
- the obstruction process of the portal vein it also causes liver stones, liver cirrhosis, liver dysfunction, causing endocrine and metabolic disorders, mainly the ability of the liver to inactivate estrogen, thus affecting the function of the entire reproductive system. This is also the reason why women have face spots, because normal liver function has the ability to inactivate estrogen and increase the content of progesterone. Therefore, the principle of treatment and prevention of reproductive system diseases is mainly to clear the blood circulation of the hepatic portal vein, which is to strengthen the use of blood stasis drugs.
- the TCM group pays attention to the principles of using drugs, such as Jun, Chen, and Zuo, and also pays attention to the use of drugs.
- Guide medicine is equivalent to the purpose of targeting. Therefore, in the treatment of the reproductive system, “Panxia Atractylodes Tianmachang” is a drug, and the drug is replaced by “Yaoyao Pill", adjuvant is to strengthen the blood circulation.
- the main ways in which mold invades the liver are: cold and cold transfer, food infection, sexual infection, mother-to-child transmission, transfusion and blood transfusion. Active treatment of colds and colds is very important. At present, it is wrong to treat anti-allergic drugs with cold and cold, because it inhibits sneezing, so that mold can not be discharged with the nose and sputum, but instead is transferred to the brain and liver. Therefore, to prevent cancer of the reproductive system, the first is to resist cold and cold.
- the drug is also composed of "Pan Xia Baizhu Tianma Tang” combined with "Xiao Chai Hu Tang” and "Yao Yao Pill” addition and subtraction.
- Xiao Chai Hu Tang and “Yao Yao Pill” are actually one side split into two parties. Plus the divergent wind cold medicine, the schizonepeta, the perilla” Can be grouped as: Pinellia, Atractylodes, Gastrodia elata, licorice, alfalfa, white peony, dried tangerine peel, ginger, wind, schizonepeta, perilla, Bupleurum, scutellaria.
- Yanhusuo is the first medicine for activating blood circulation and relieving pain.
- the medicine is: Xin, bitter and warm. It can treat all the pain in the whole body.
- Its chemical composition mainly contains a variety of alkaloids. It is these alkaloids that can inhibit and kill molds, and spread the molds in the blood to spread out with the blood, so as to clear the blood vessels, and the blood is smooth and natural. eliminated.
- Corydalis is often used in combination with "Xiangfu” to promote the synergy of blood circulation. Xiangfu is a qi medicine.
- Liangqi means to help the smooth exchange of oxygen and carbon dioxide in the blood, and also promote the discharge of carbon dioxide. Therefore, blood stasis and phlegm medicine are generally used together with qi medicine to make the gas and blood clear at the same time.
- the chemical constituents of Xiangfu contain volatile oils and alkaloids, which have the effect of inhibiting mold and virus.
- Yu Jin medicine; Xin, bitter, cold. It is a blood-activating and stasis-relieving drug that targets the liver. Its chemical composition contains a variety of volatile oils, and it is these volatile oils that inhibit mold, viruses, and bacilli. There is a combination of gold and qi medicine “woody incense”, woody temperature, complementary to the coldness of turmeric. The chemical constituents of woody notes also contain volatile oils and alkaloids.
- the third combination of prescriptions is: Pinellia, Atractylodes, Gastrodia elata, Corydalis, Xiangfu, Muxiang, Licorice, Angelica, Poria, Angelica, Chenpi, Cinnamon, Ginger, Astragalus, Codonopsis, Rehmannia, Musk, Atractylodes, Magnolia, ⁇ , ⁇ .
- Rhizoma Curcumae and Trigonium are volatile oils, which inhibit mold, viruses and bacteria.
- Adding or subtracting these drugs will form the fourth combination of prescriptions: Pinellia, Atractylodes, Gastrodia elata, Corydalis, Xiangfu, Muxiang, Licorice, Angelica, Poria, Angelica, Poria, Aconite, Ginger, Astragalus, Codonopsis, Rehmannia, Atractylodes, Magnolia, ⁇ Fangfeng, ⁇ , spatholobus, ⁇ ⁇ , ⁇ ⁇ .
- the sixth combination of prescriptions is: Pinellia, Atractylodes, Gastrodia elata, Corydalis, Xiangfu, Muxiang, Licorice, Angelica, Poria, Angelica, Poria, Ginger, Atractylodes, Magnolia, Rhythm, Wolfberry, Chicken Blood Rattan, Niuqi, Alisma, Duhuo, Mulberry, Asarum, Chuanxiong, Baiji.
- Fangzhong Tianma, Chuanxiong and Radix Paeoniae Alba are targeted to the high blood pressure caused by liver.
- the spatholobus, sedum, mulberry, and asarum are targeted to the hypertension caused by the kidney.
- the brain venous lesion caused by liver is in the left forehead, and the toxin is discharged through the left nasal cavity; while the brain venous lesion caused by the kidney is in the occipital region of the brain, and the toxin is discharged through the right nasal cavity.
- P is further advanced when the disease progresses further. At this time, there are headaches and multiple pains in the body. It is the liver, spleen and kidney of the Chinese medicine. At this time, it is necessary to increase the treatment of brain, lung peony and anti-rheumatic pain medicine, diuretic swelling.
- Chinese medicine believes that treating diseases should be treated with both "medication and diet”. Therefore, Chinese medicine pays great attention to diet therapy. When taking medicine, the diet should be properly matched and can play an auxiliary therapeutic role.
- Chinese medicine pays attention to soup, that is, chicken, pig, sheep, cattle and other meat-bone compatibility: onion, ginger, garlic, pepper, pepper, star anise, cinnamon, cumin, fragrant leaves, grass fruit, cloves and other spices. These spices have the function of inhibiting mold, virus and bacillus, and the bones supplement the nutrients necessary for the human body, and play the role of qi and blood to enhance the body's resistance. Especially beef and beef bones, the effect is quite yellow.
- PCT/CN2013/080936 patent treatment focuses on the brain, Treat liver and kidneys.
- the main medicine is to treat headaches, and the principle of medication is to promote drainage and sputum. Therefore, the composition of the medicinal herbs is different. It is composed of "Jade Pot Pills” combined with “Pingwei San” and the medicine “White peony and Chuanxiong”.
- the medicine is composed of " ⁇ " and "Danihuo parasitic soup", which is intended to strengthen the effect of relieving pain and rheumatism.
- the adjuvant is a drug for diuretic swelling.
- the focus of the treatment of the present invention is in the liver, which treats both the kidney and the brain.
- the composition of the present invention is: "Pan Xia Baizhu Tianma Tang” is a medicinal herb, and the drug is replaced by “Xiaoyao Pill”, and the adjuvant is to strengthen the blood circulation and phlegm.
- the principle of medication is to clear the blood circulation of the liver.
- the stage of treatment is different.
- Application No. PCT/CN2013/080936 is for the treatment of advanced cancer. Because when there are frequent headaches and multiple pains in the body, cancer is already in the advanced stage. At this time, the renal function is also seriously damaged, and the edema is more obvious. Therefore, in the adjuvant should be combined with a variety of diuretic swelling drugs.
- the present invention is for the prevention of cancer, as well as early and mid-stage cancer treatment. Therefore, it can also be used for precancerous lesions such as hypertension, hyperlipidemia, diabetes, etc., and can also stain spots and lose weight.
- Formula for preventing cancer of the reproductive system 0-50 parts of Pinellia, 0 ⁇ 50 parts of Atractylodes, 0-50 parts of Tianma, 0 ⁇ 50 parts of licorice, 0 ⁇ 50 parts of ⁇ , 0 ⁇ 50 parts of white peony, dried tangerine peel 0 ⁇ 50 parts, 0 ⁇ 50 parts of ginger, 0 ⁇ 50 parts of P square wind, 0 ⁇ 50 parts of schizonepeta, 0 ⁇ 50 parts of perilla, 0 ⁇ 50 parts of Bupleurum, 0 ⁇ 50 parts of astragalus.
- the composition of the drug substance is increased and decreased.
- the prescription of the drug substance is increased or decreased: 0-50 parts of Pinellia, 0-50 parts of Atractylodes, 0-50 parts of Tianma, 0 ⁇ 50 parts of Corydalis, and 0 ⁇ 50 parts, 0 ⁇ 50 parts of woody, 0 ⁇ 50 parts of licorice, 0 ⁇ 50 parts of Chinese angelica, 0 ⁇ 50 parts of ⁇ , 0 ⁇ 50 parts of white peony, 0 ⁇ 50 parts of medlar, 0 ⁇ 50 parts of ginger, 0 ⁇ 50 copies of Atractylodes, 0 ⁇ 50 copies of Magnolia, 0 ⁇ 50 copies of P-square, ⁇ 0-50 parts, 0-50 parts of spatholobus stem, 0-50 parts of beef seven, 0-50 parts of Alisma, 0-50 parts of solo, 0 ⁇ 50 parts of mulberry, 0 ⁇ 50 parts of asarum, Chuanxiong 0 ⁇ 50
- the above-mentioned 1, 2, 3, 4, 5, 6 pharmaceutical compositions of the present invention are added to various conventional excipients, such as disintegrants, lubricants, adhesives and the like, which are required for preparing different dosage forms, and are prepared by a conventional traditional Chinese medicine preparation method.
- the dosage forms include: pills, capsules, tablets, powders, granules or oral solutions, syrups and the like. It can also be directly made into Chinese herbal medicine pieces to make health tea.
- the above-mentioned 1, 2, 3, 4, 5, and 6 pharmaceutical compositions of the present invention can also be prepared into a biological preparation by extracting effective chemical components from a bulk drug by a modern pharmaceutical method: alkaloids and volatile oils, and other effective chemicals.
- Dosage forms include: oral preparations (capsules, tablets, granules or oral liquids, etc. (including various doses) and external medicines (including health care products).
- oral preparations capsules, tablets, granules or oral liquids, etc. (including various doses) and external medicines (including health care products).
- the above 1, 2, 3, 4, 5, 6 groups of the present invention The pharmaceutical composition can be prepared into different dosages according to different age groups and genders.
- the above pharmaceutical composition of the present invention can be adapted to: medical drugs, health foods, health care products, animal drugs, animal materials.
- the drug has the following advantages:
- the sources of various raw materials are easy to obtain and easy to promote.
- the medicine of the invention has the effects of killing mold, dissolving the mold group and excreting the mold, and improving the liver and kidney functions.
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Abstract
一种预防和治疗生殖系统癌症的药物组合物及其制备方法,所述药物组合物是以半夏、白术、天麻、甘草、茯苓、白芍、生姜等的任意一种或多种作为原料药制成的。
Description
—种治疗生殖系统癌症的药物组合及其制备方法
技术领域 本发明创造属医疗保健领域 ,是一种预防和治疗生殖系统癌症的药物组 合 ,适用范围:乳腺增生、 乳腺癌、 肝结石、 肝硬化、 肝癌、 子宫肌瘤、 子宫内 膜癌、 卵巢癌、 前列腺增生、 前列腺癌等归属生殖系统的疾病 ,同时还可以预防 与治疗胃溃疡、 胃癌。本发明是一种以中草药为原料药的治疗与预防生殖系统癌 症的药物组合及其制备方法。 背景技术 癌症是人类首要的死亡原因。 据世卫组织估计 ,如不进行干预 , 2005年 至 2015年期间将有 8400万人死于癌症。 2004年,癌症死亡人数达 740万(约 占所有死亡人数的 13% 超过 70%的癌症死亡发生在低收入和中等收入国家。 预计全世界癌症死亡将继续增加, 2030年估计将有 1200万人死于癌症。
到目前为止,化疗、 放疗的效果不明显,还存在毒副作用大等缺陷,用药 后病人反应强烈,痛苦程度高。 早期手术治疗容易复发和转移,疗'效也不明显。 发明内容 本发明所要解决的技术问题是克服以上治疗癌症方法的缺陷,提供一种 疗'效显著、 成本 ί氐廉、 毒副作用小的治疗生殖系统癌症的药物组合。
本人在硏究中医理论的过程中,发现《历代名医医案选析》中金代名医张 元素对《头痛案》的分析,对张氏所谓的《头痛案》 "厥阴、 太阴合病,名曰风 痰头痛" 进行仔细辨证 ,再对足厥阴肝经 ,足太阴脾经进行逻辑推理 ,运用中西 医理论 ,得出张氏所说的 "厥阴病" 为肺癌合并脑瘤。 "太阴病" 为肝癌。 因此 "风痰头痛" 就是肺癌合并脑瘤伴肝转移。 张元素用《玉壶丸》治疗此病 ,本人 结合其方解发现《半夏白术天麻汤》 (组成:半夏、 天麻、 白术、 茯苓、 陈皮、 甘草、生姜)是一剂治疗全身癌症的基础方。并在此基础上进一步分析,发现 "真 菌"才是导致各种癌症的主要因素之一。生殖系统的癌变主要由白色念珠菌导致。
根据中医理论 ,生殖系统主要归属肝经 ,从属脾经、 肾经。 现代医学已证明 正常女性月经周期的建立有赖于下丘脑-垂体-卵巢轴之间的神经内分泌调节 ,以 及子宫内膜对性激素变化的周期反应,肝脏有调节性激素的作用。本人前期也已 破解肝经主要反映的是脑部的病变 ,而脾经主要反映的是肝脏、脾脏的病变。 中 医对生殖系统疾病用药原则是 "疏肝健脾" ,所谓 "疏肝健脾" 的意思是疏通血 管、 补充营养;消除水肿 ,增强肝、 脾、 胰等内脏的功能。 代表方为《逍遥丸》 (组成:甘草、 当归、 茯苓、 白芍、 白术、 柴胡),《逍遥丸》主要是作用于早期 乳腺增生、 月经不调等疾病。 方中当归、 白芍用于疏通肝脏、 脾脏的血液循环 , 起活血补血的作用;白术、 茯苓用于消除肝脏、 脾脏细胞内的水肿 ,白术的化学 成分含挥发油 ,具有抑制霉菌的作用;柴胡则作用于肝脏血液里的病毒感染;甘 草为辅助药 ,起调和作用。 从这六味原料药的作用来分析 ,其作用的功效弱小 , 起不到治疗作用。而且 "柴胡" 主要用于治疗病毒感染,当 "肝风内动"时忌用, 即当出现癌变时不能用。
在《破解中医治疗肺癌合并脑瘤伴肝癌转移的方剂》中,发现半夏、 天麻为
治疗全身癌症的君药。 因此 ,在治疗生殖系统的癌症中 ,半夏、 天麻还是君药 , 但与治疗肺癌合并脑瘤伴肝癌转移不同的是:肺癌合并脑瘤伴肝癌转移的重点在 于对脑部的治疗,而生殖系统的癌症重点是对肝脏的治疗力度。因肝经出自于肝 门静脉 ,当霉菌、 病毒感染肝门静脉后 ,容易阻塞肝门静脉 ,引起门静脉高压 , 导致许多静脉曲张。 P逭着霉菌进一步侵犯 ,当门静脉发生阻塞后 ,则门静脉和腔 静脉间的吻合支逐渐扩张形成側支循环,使门静脉血经側支循环进入腔静脉流入 心脏。 主要的側支循环有: 1、 食管下段静脉和胃冠状静脉曲张 ,这是导致消化 道大出血的原因。 2、 腹壁及脐周围静脉网曲张。 3、 痔静脉丛曲张 ,这是痔痊 出血的原因。 同时随着门静脉的阻塞进程 ,也导致肝结石、 肝硬化 ,使肝功能不 全 ,引起内分泌代谢障碍 ,主要是肝脏对雌激素的灭活能力降 ί氐 ,从而影响了整 个生殖系统的功能。这也是女人出现脸上色斑的原因,因为正常的肝功能具有灭 活雌激素,增加黄体酮的含量的能力。因此治疗与预防生殖系统疾病的用药原则 主要是疏通肝门静脉的血液循环 ,这就要加强活血化瘀药的使用。
中医组方讲究君、 臣、 佐、 使配伍用药原则, 也讲究引经药的使用, "引经 药"就相当于靶向作用的意思。因此在对生殖系统的治疗中,《半夏白术天麻场》 是君药 ,而臣药则换成《逍遥丸》 ,佐药就是要加强活血化瘀的药。
霉菌入侵肝脏的途径主要有:风寒感冒转移、食物传染、性传染、母婴传染、 输液输血传染等。积极治疗风寒感冒是非常重要的。 目前治疗风寒感冒喜用抗过 敏的药是错误的 ,因为它抑制了打喷嚏 ,使霉菌不能随鼻涕、 痰液排出 ,反而向 脑部和肝脏转移。因此要预防生殖系统癌变,首先是抗风寒感冒。药物也是由《半 夏白术天麻汤》合并《小柴胡汤》和《逍遥丸》加减组成。 《小柴胡汤》与《逍 遥丸》其实就是一方被分拆成两方。 再加上发散风寒药 方风、 荊芥、 紫苏"便
可组方为:半夏、 白术、 天麻、 甘草、 茯苓、 白芍、 陈皮、 生姜、 防风、 荊芥、 紫苏、 柴胡、 黄芩。
当霉菌侵入肝脏后 ,就必须加速肝脏的血液循环 ,使霉菌不能繁殖。在活血 化瘀药中, "延胡索" 为活血行气止痛第一药,药性:辛、 苦、 温。 能治疗全身 上下的所有疼痛。其化学成分主要含多种生物碱 ,正是这些生物碱能抑制和杀死 霉菌 ,并把血液中聚集成团的霉菌发散开随血液排走 ,起疏通血管的作用 ,血液 通畅自然疼痛就消除了。 延胡索常与 "香附" 配伍 ,使活血行气协同作用。 香附 属理气药 , "理气" 的意思是指帮助血液中的氧气与二氧化碳顺利交换 ,同时也 促使二氧化碳排出。 因此活血化瘀药一般都与理气药并用 ,使气和血同时疏通。 香附的化学成分含挥发油和生物碱 ,具有抑制霉菌、 病毒的作用。
"郁金"药性;辛、 苦、 寒。 是靶向作用于肝脏的活血化瘀药。 其化学成分 含多种挥发油 ,正是这些挥发油具有抑制霉菌、 病毒、 杆菌的作用。 有金常与理 气药 "木香" 配伍 ,木香性温 ,互补郁金的寒性。 木香的化学成分也含挥发油和 生物碱。
因为肝脏毒素的排泄主要是通过大便、尿液排出。女人还可通过月经血排出。 因此就要配伍作用于肾经的药物。因是早期 ,症状轻微 ,选用《苓桂术甘汤》(组 成:茯苓、 桂枝、 白术、 甘草 ) ,此方也是《半夏白术天麻汤》的分拆方 ,就是 增加一味 "桂枝"药。 又因霉菌对肝脏病变的早期为微小结石 ,故要增加化石利 尿药 "金钱草"、 化湿药 "藿香和厚朴"
因此综合《半夏白术天麻汤》、《逍遥丸》加减 ,便组成治疗早期生殖系统癌 症的药物组方为:半夏、 白术、天麻、延胡索、香附、木香、甘草、当归、茯苓、 白芍、 有金、 陈皮、 桂枝、 金钱草、 生姜、 藿香、 厚朴。
Pit着病情的进一步发展 ,肝功能、 脾功能开始减退 ,出现胃胀、 肥胖、 月经 量多、 月经期长等症状时 ,就必须增加补气补血的药物。 中医认为月经血过多 , 是脾虚的原因 ,即脾不统血。 在补气药中 , "黄芪" 为第一药 ,配伍 "党参" ,能 相互增强疗效。 补血药除当归外,再增加 "熟地"。 同时增强治疗 "湿邪" 的药 力 ,加入 "苍术、 Ρ方风";改桂枝为 "肉桂" ,去郁金、 金钱草力卩 "萆解"。 便组 成第三张组合药方为:半夏、 白术、 天麻、 延胡索、 香附、 木香、 甘草、 当归、 茯苓、 白芍、 陈皮、 肉桂、生姜、黄芪、 党参、熟地、藿香、苍术、厚朴、 Ρ方风、 萆蘚。
再随着肝功能的进一步减退,且肾功能也减退。即中医所说的由虚证转为实 证。 此时出现的症状有:月经量少、 乳腺增生、 子宫肌瘤、 前列腺增生、 心烦失 眠、 口干、 色素沉着、 腰酸痛、 下肢怕冷等症状。 这时就要针对症状加强用药。 活血调经药中的 "鸡血藤"可调经止痛,且补血、暖腰肾。加上破血消肿瘤药 "莪 术"、 "三棱",同时去除肉桂,改为 "附子" 卩强抗真菌的作用,也去除藿香、 陈皮力卩 "枳实"。 莪术、 三棱的主要化学成分为挥发油 ,有抑制霉菌、 病毒、 杆 菌的作用。 增减这些药便组成第四张组合药方为:半夏、 白术、 天麻、 延胡索、 香附、木香、甘草、 当归、茯苓、 白芍、枳实、 附子、生姜、黄芪、 党参、熟地、 苍术、 厚朴、 ρ方风、 萆蘚、 鸡血藤、 莪术、 三棱。
Pit着肝、 脾、 肾等内脏的功能进一步下降 ,即中医所说的肝肾阴虚。 此时临 床症状增加了浮肿、糖尿病的症状 ,还出现脚跟痛等症状。病情的发展已到了癌 症的中期。 这时就要加强对肾脏的治疗 ,增加利尿消肿药 "泽泻、 猪苓" ,去莪 术、三棱改为 "牛七" ,去党参改为 "人参" ,以恢复肾功能。并增加祛风湿药 "独 活、 桑寄生、 细辛"。 于是组成第五张组合药方:半夏、 白术、 天麻、 延胡索、
香附、木香、甘草、 当归、茯苓、 白芍、枳实、 附子、生姜、黄芪、人参、熟地、 苍术、 厚朴、 P方风、 萆蘚、 鸡血藤、 牛七、 泽泻、 猪苓、 独活、 桑寄生、 细辛。
当生殖系统早期癌症合并高血压时,就要增加疏通脑部血管的药 "川芎、 白 芷" ,去黄芪、 人参、 熟地、 附子、 猪苓。 便组成第六张组合药方为:半夏、 白 术、天麻、延胡索、香附、木香、甘草、 当归、茯苓、 白芍、枳实、生姜、苍术、 厚朴、 防风、 萆蘚、 鸡血藤、 牛七、 泽泻、 独活、 桑寄生、 细辛、 川芎、 白芷。 方中天麻、川芎、白芷是靶向作用于肝经引起的高血压,鸡血藤、独活、桑寄生、 细辛是靶向作用于肾经引起的高血压。根据本人的临床体会,肝经引起的脑部静 脉病变在左前额,其毒素通过左侧鼻腔排出;而肾经引起的脑部静脉病变在脑后 枕部 ,其毒素通过右側鼻腔排出。
P逭着病情再进一步发展就到了晚期了 ,这时就出现头痛及全身多处疼痛。 就 是中医讲的肝经、 脾经、 肾经三阴合病。 这时就要增加治疗脑部、 肺部祛痰药和 抗风湿痛药、 利尿消肿的药了。
中医认为治疗疾病应 "药疗与食疗"并重。 因此中医非常注重饮食疗法 ,在 服用药物时,饮食要搭配合理,能起辅助治疗作用。中医注重煲汤,即用鸡、猪、 羊、牛等连肉带骨配伍:葱、姜、蒜、胡椒、花椒、八角、桂皮、小茴香、香叶、 草果、 丁香等辛香料一起煮。 这些辛香料具有抑制霉菌、 病毒、 杆菌的作用 ,骨 肉补充了人体所必须的营养 ,起补气补血的作用 ,增强了人体抵抗力。尤其是牛 肉、 牛骨,功效相当黄芪。
―、 本发明与申请号 PCT/CN2013/080936国际专利的鉴别:
1、 治疗的重点不同: PCT/CN2013/080936号专利治疗的重点在脑部 ,兼
治肝脏、 肾脏。 药品主要是治疗头痛 ,用药原则是促使排痰液和鼻涕。 因此其君 药组成不同,是由《玉壶丸》合并《平胃散》加引经药 "白芷、 川芎" 组成。 臣 药由《羌活胜湿汤》和《独活寄生汤》组成 ,意在加强止痛祛风湿的作用。 佐药 为利尿消肿的药。 而本发明治疗的重点在肝脏 ,兼治肾脏、 脑部。 因霉菌是随血 液循环侵犯全身的 ,故中医治疗讲究全身用药 ,又有側重点。 因此本发明的组成 是:《半夏白术天麻汤》是君药 ,而臣药则换成《逍遥丸》 ,佐药就是要加强活血 化瘀的药。 用药原则是疏通肝脏的血液循环。
2、治疗的病变阶段不同。申请号 PCT/CN2013/080936号专利是用于中、 晚期癌症。 因为当出现经常头痛、 全身多处疼痛时,癌症就已是中晚期了。 此时 的肾功能也损伤较严重 ,浮肿较明显。所以在佐药中要联合多种利尿消肿药。而 本发明是用于预防癌症、 以及早期、 中期的癌症治疗。 因此也可用于高血压、 高 血脂症 ,糖尿病等癌前病变 ,还可以祛色斑、 减肥。
二、 组合药物制备方法
1、用于预防生殖系统癌症的方剂:半夏 0-50份、白术 0~50份、天麻 0-50 份、 甘草 0~50份、 茯苓 0~50份、 白芍 0~50份、 陈皮 0~50份、 生姜 0~50 份、 P方风 0~50份、 荊芥 0~50份、 紫苏 0~50份、 柴胡 0~50份、 黄芩 0~50 份。
2、 在 1的基础上加减组成用于治疗早期生殖系统癌症的方剂:半夏 0-50 份、白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50份、木香 0~50 份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 有金 0~50 份、陈皮 0-50份、桂枝 0-50份、金钱草 0-50份、生姜 0-50份、藿香 0-50 份、 厚朴 0~50份。
3、在 2的基础上当出现月经量多时增减原料药组成的方剂半夏 0-50份、 白术 0~50份、天麻 0-50份、延胡索 0~50份、香附 0~50份、木香 0-50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 陈皮 0~50份、 肉桂 0~50份、 生姜 0~50份、 黄芪 0~50份、 党参 0~50份、 熟地 0~50份、 藿香 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、 萆蘚 0~50份。
4、 在 3的基础上当出现有肿块时增减原料药组成的方剂:半夏 0-50份、 白术 0~50份、天麻 0-50份、延胡索 0~50份、香附 0~50份、木香 0-50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50份、 附子 0~50份、 生姜 0~50份、 黄芪 0~50份、 党参 0~50份、 熟地 0~50份、 苍术 0-50份、厚朴 0~50份、 P方风 0-50份、萆蘚 0-50份、鸡血藤 0-50份、 莪术 0~50份、 三棱 0~50份。
5、在 4的基础上当出现浮肿、足跟痛合并糖尿病时增减原料药组成的方剂: 半夏 0-50份、白术 0~50份、天麻 0-50份、延胡索 0~50份、香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50份、 附子 0~50份、 生姜 0~50份、 黄芪 0~50份、 人参 0~50份、 熟地 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、 萆蘚 0~50份、 鸡血藤 0~50份、 牛七 0~50份、 泽泻 0~50份、 猪苓 0~50份、 独活 0〜份、 桑寄生 0~50份、 细辛 0~50份。
6、在 5的基础上当生殖系统癌症早期合并高血压时增减原料药组成的方剂: 半夏 0-50份、白术 0~50份、天麻 0-50份、延胡索 0~50份、香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50份、 生姜 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、
萆蘚 0-50份、鸡血藤 0-50份、牛七 0-50份、泽泻 0-50份、独活 0-50份、 桑寄生 0~50份、 细辛 0~50份、 川芎 0~50份、 白芷 0~50份。 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物加入制备不同剂型时所需的 各种常规辅料 ,例如崩解剂、润滑剂、黏合剂等以常规的中药制剂方法制备成任 何一种常用的口服制剂 ,剂型包括:丸剂、 胶囊剂、 片剂、 散剂、 颗粒剂或口服 液、 糖浆等。 也可直接炮制成中药饮片制成保健茶。 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物还可以现代制药方法从原料 药中提取有效化学成分 :生物碱和挥发油以及其他有效化学物质制备成生物制剂。 剂型包括:口服制剂 (胶囊剂、 片剂、 颗粒剂或口服液等 X 针剂 (包含各种剂 量)以及外用药品(含保健用品) 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物可以根据不同年龄段及男女 差别化制备成不同的剂量。 本发明的上述药物组合物的适应范围为:医疗药品、 保健食品、 保健用品、 动物药品、 动物词料。 三、 本发明药物具有以下优点:
1、 符合国家药典。
2、 使用方便、 安全。
3、 疗效确切 ,副作用小。
4、 各种原料药来源易得、 容易推广。
5、 中成药生产工艺成熟、 简单且造价低廉。
6、 生物制剂的原料提取技术也成熟。
7、 从秦汉时期到现代已有二千多年的临床人体试验证明疗效确切。
8、 相比化学合成药品,本发明的药品具有杀灭霉菌、化解霉菌团并把 霉菌排出体外的功效 ,还有修复肝、 肾功能的疗效。 参考文献
【1】 邓中甲. 全国高等中医药院校规划教材《方剂学》 . 中国中医 药出版社, 2009年 9月.
【2】 高学敏. 全国高等中医药院校规划教材《中药学》 . 中国中医 药出版社, 2009年 9月.
【3】 易法银、 胡方林. 历代名医医案选析. 化学工业出版社医学 出版分社, 2008年 4月. P50 和瑞芝. 病理学. 人民卫生出版社, 2001年 5月第 4版.
Claims
1、 一种预防与治疗生殖系统癌症的药物组合物 ,其特征是用于预防生殖系统癌 症的主要由以下重量份的原料药组成:方剂:半夏 0-50份、 白术 0~50份、 天 麻 0~50份、 甘草 0~50份、 茯苓 0~50份、 白芍 0~50份、 陈皮 0~50份、 生 姜 0~50份、 P方风 0~50份、 荊芥 0~50份、 紫苏 0~50份、 柴胡 0~50份、 黄 芩 0~50份。
2、 在权利要求 1的基础上加减 ,其特征是用于治疗早期生殖系统癌症的原料药 组成:半夏 0-50份、 白术 0~50份、 天麻 0-50份、 延胡索 0~50份、 香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 有金 0~50份、 陈皮 0~50份、 桂枝 0~50份、 金钱草 0~50份、 生 姜 0~50份、 藿香 0~50份、 厚朴 0~50份
3、 在权利要求 2的基础上加减 ,其特征是当出现月经量多时的原料药组成:半 夏 0~50份、 白术 0~50份、 天麻 0~50份、 延胡索 0~50份、 香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 陈皮 0~50份、 肉桂 0~50份、 生姜 0~50份、 黄芪 0~50份、 党参 0~50份、 熟地 0~50份、 藿香 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、 萆蘚 0~50份。
4、在权利要求 3的基础上加减其特征当出现有肿块时的原料药组成半夏 0~50 份、白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50份、木香 0~50 份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50 份、 附子 0~50份、 生姜 0~50份、 黄芪 0~50份、 党参 0~50份、 熟地 0~50 份、苍术 0-50份、厚朴 0~50份、 P方风 0-50份、萆蘚 0-50份、鸡血藤 0-50
份、 莪术 0~50份、 三棱 0~50份。
5、 在权利要求 4的基础上加减,其特征是当出现浮肿、 足跟痛合并糖尿病时的 原料药组成:半夏 0-50份、 白术 0~50份、 天麻 0-50份、 延胡索 0~50份、 香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50份、 附子 0~50份、 生姜 0~50份、 黄芪 0~50份、 人参 0~50份、 熟地 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、 萆蘚 0-50份、鸡血藤 0-50份、牛七 0-50份、泽泻 0-50份、猪苓 0-50份、 独活 0〜份、 桑寄生 0~50份、 细辛 0~50份。
6、 在权利要求 5的基础上加减 ,其特征是:当生殖系统癌症早期合并高血压时 增减原料药组成的方剂:半夏 0~50份、 白术 0~50份、 天麻 0~50份、 延胡索 0~50份、 香附 0~50份、 木香 0~50份、 甘草 0~50份、 当归 0~50份、 茯苓 0~50份、 白芍 0~50份、 枳实 0~50份、 生姜 0~50份、 苍术 0~50份、 厚朴 0~50份、 P方风 0~50份、 萆蘚 0~50份、 鸡血藤 0~50份、 牛七 0~50份、 泽 泻 0~50份、 独活 0~50份、 桑寄生 0~50份、 细辛 0~50份、 川芎 0~50份、 白芷 0~50份。
7、 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物加入制备不同剂型时所需的 各种常规辅料 ,例如崩解剂、润滑剂、黏合剂等以常规的中药制剂方法制备成任 何一种常用的口服制剂 ,剂型包括:丸剂、 胶囊剂、 片剂、 散剂、 颗粒剂或口服 液、 糖浆等。 也可直接炮制成中药饮片制成保健茶。
8、 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物还可以现代制药方法从原料 药中提取有效化学成分 :生物碱和挥发油以及其他有效化学物质制备成生物制剂。
剂型包括:口服制剂 (胶囊剂、 片剂、 颗粒剂或口服液等 X 针剂 (包含各种剂 量)以及外用药品(含保健用品)
9、 本发明的上述 1、 2、 3、 4、 5、 6组药物组合物可以根据不同年龄段及男女 差别化制备成不同的剂量。
10、 本发明的上述药物组合物的适应范围为:医疗药品、 保健食品、 保健用 品、 动物药品、 动物词料。 专利保护主体的结构
1、 半夏 0~50份、 白术 0~50份、 天麻 0~50份、 甘草 0~50份、 茯苓 0~50 份、白芍 0~50份、陈皮 0~50份、生姜 0~50份、 P方风 0~50份、荊芥 0~50 份、 紫苏 0~50份、 柴胡 0~50份、 黄芩 0~50份。
2、半夏 0~50份、 白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50 份、木香 0~50份、甘草 0~50份、当归 0~50份、茯苓 0~50份、白芍 0~50 份、 有金 0-50份、 陈皮 0-50份、 桂枝 0-50份、 金钱草 0-50份、 生姜 0~50份、 藿香 0~50份、 厚朴 0~50份。
3、半夏 0~50份、 白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50 份、木香 0~50份、甘草 0~50份、当归 0~50份、茯苓 0~50份、白芍 0~50 份、陈皮 0~50份、肉桂 0~50份、生姜 0~50份、黄芪 0~50份、党参 0~50 份、熟地 0-50份、藿香 0-50份、苍术 0-50份、厚朴 0~50份、 P方风 0-50 份、 萆蘚 0~50份。
4、半夏 0~50份、 白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50 份、木香 0~50份、甘草 0~50份、当归 0~50份、茯苓 0~50份、白芍 0~50
份、枳实 0-50份、附子 0-50份、生姜 0-50份、黄芪 0-50份、党参 0-50 份、熟地 0-50份、苍术 0-50份、厚朴 0~50份、 P方风 0-50份、萆蘚 0-50 份、 鸡血藤 0~50份、 莪术 0~50份、 三棱 0~50份。
、半夏 0~50份、 白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50 份、木香 0~50份、甘草 0~50份、当归 0~50份、茯苓 0~50份、白芍 0~50 份、枳实 0-50份、附子 0-50份、生姜 0-50份、黄芪 0-50份、人参 0-50 份、熟地 0-50份、苍术 0-50份、厚朴 0~50份、 P方风 0-50份、萆蘚 0-50 份、 鸡血藤 0-50份、 牛七 0-50份、 泽泻 0-50份、 猪苓 0-50份、 独活 0〜份、 桑寄生 0~50份、 细辛 0~50份。
、半夏 0~50份、 白术 0~50份、天麻 0~50份、延胡索 0~50份、香附 0~50 份、木香 0~50份、甘草 0~50份、当归 0~50份、茯苓 0~50份、白芍 0~50 份、枳实 0-50份、生姜 0-50份、苍术 0-50份、厚朴 0~50份、 P方风 0-50 份、 萆蘚 0~50份、 鸡血藤 0~50份、 牛七 0~50份、 泽泻 0~50份、 独活 0~50份、 桑寄生 0~50份、 细辛 0~50份、 川芎 0~50份、 白芷 0~50份。
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CN109432344A (zh) * | 2013-03-11 | 2019-03-08 | 肖鸣春 | “化湿药”在制备抗霉菌的药物或保健品中的应用 |
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CN109432259A (zh) | 2019-03-08 |
CN109512987A (zh) | 2019-03-26 |
CN110025748A (zh) | 2019-07-19 |
CN109432365A (zh) | 2019-03-08 |
CN109453307A (zh) | 2019-03-12 |
CN109663087A (zh) | 2019-04-23 |
CN109731055A (zh) | 2019-05-10 |
CN109498783A (zh) | 2019-03-22 |
CN109663097A (zh) | 2019-04-23 |
CN109432331A (zh) | 2019-03-08 |
CN104043068A (zh) | 2014-09-17 |
CN109731042A (zh) | 2019-05-10 |
CN109432253A (zh) | 2019-03-08 |
CN104918628A (zh) | 2015-09-16 |
CN109550028A (zh) | 2019-04-02 |
CN110025715A (zh) | 2019-07-19 |
CN109498764A (zh) | 2019-03-22 |
WO2014139255A1 (zh) | 2014-09-18 |
CN109498687A (zh) | 2019-03-22 |
CN110025761A (zh) | 2019-07-19 |
CN109432180A (zh) | 2019-03-08 |
CN109663022A (zh) | 2019-04-23 |
US20150283197A1 (en) | 2015-10-08 |
US20150374778A1 (en) | 2015-12-31 |
CN103394067A (zh) | 2013-11-20 |
CN109498769A (zh) | 2019-03-22 |
CN109432344A (zh) | 2019-03-08 |
US9498508B2 (en) | 2016-11-22 |
US9744206B2 (en) | 2017-08-29 |
CN105377281A (zh) | 2016-03-02 |
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