CN108355045B - 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 - Google Patents
一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 Download PDFInfo
- Publication number
- CN108355045B CN108355045B CN201810499630.6A CN201810499630A CN108355045B CN 108355045 B CN108355045 B CN 108355045B CN 201810499630 A CN201810499630 A CN 201810499630A CN 108355045 B CN108355045 B CN 108355045B
- Authority
- CN
- China
- Prior art keywords
- prostatic hyperplasia
- medicine
- traditional chinese
- chinese medicine
- kidney deficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 76
- 210000003734 kidney Anatomy 0.000 title claims abstract description 43
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 29
- 208000026435 phlegm Diseases 0.000 title claims abstract description 29
- 230000007812 deficiency Effects 0.000 title claims abstract description 25
- 150000001875 compounds Chemical class 0.000 title claims abstract description 24
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 19
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title claims description 34
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title claims description 33
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 241000935235 Fritillaria meleagris Species 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 240000001417 Vigna umbellata Species 0.000 claims abstract description 12
- 235000011453 Vigna umbellata Nutrition 0.000 claims abstract description 12
- 239000000706 filtrate Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- 241000096284 Gynochthodes officinalis Species 0.000 claims abstract description 10
- 235000012874 Phaseolus calcaratus Nutrition 0.000 claims abstract description 10
- 244000153955 Reynoutria sachalinensis Species 0.000 claims abstract description 9
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 240000000031 Achyranthes bidentata Species 0.000 claims abstract description 7
- 244000081426 Ranunculus ficaria Species 0.000 claims abstract description 7
- 235000002226 Ranunculus ficaria Nutrition 0.000 claims abstract description 7
- 238000009835 boiling Methods 0.000 claims abstract description 7
- 238000002791 soaking Methods 0.000 claims abstract description 5
- 240000001341 Reynoutria japonica Species 0.000 claims description 4
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 abstract description 9
- 206010020718 hyperplasia Diseases 0.000 abstract description 5
- 230000003203 everyday effect Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 description 13
- 229940079593 drug Drugs 0.000 description 11
- 230000027939 micturition Effects 0.000 description 11
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 235000019640 taste Nutrition 0.000 description 9
- 206010013990 dysuria Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 210000000582 semen Anatomy 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 206010029446 nocturia Diseases 0.000 description 4
- 210000002435 tendon Anatomy 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 241000605372 Fritillaria Species 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010046555 Urinary retention Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 241000427159 Achyranthes Species 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 244000082204 Phyllostachys viridis Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000218158 Clematis Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241001083527 Dicentra Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 244000126155 Lycopus uniflorus Species 0.000 description 1
- 235000002280 Lycopus uniflorus Nutrition 0.000 description 1
- 241000978093 Metaplexis Species 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 240000004064 Poterium sanguisorba Species 0.000 description 1
- 235000008291 Poterium sanguisorba Nutrition 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 235000008282 Sanguisorba officinalis Nutrition 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 241001330502 Stephania Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241001471302 Tachysurus Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007322 compensatory function Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 208000005346 nocturnal enuresis Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 229910052957 realgar Inorganic materials 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000009910 sargent gloryvine Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000010356 tongguan Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法，涉及中药复方。中药复方按质量比可由以下原料组成：巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。按组成原料混合，放入煎药容器中，再加入水，浸泡，先用武火煮沸后，再改文火煎煮，得药液；用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；两次煎煮得到的滤液混合后即为内服药物。所得内服药物的用法为：每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
Description
技术领域
本发明涉及中药复方，尤其涉及一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法。
背景技术
前列腺增生(BPH)是男性中老年人常见的泌尿系统疾病之一，随生活压力日渐加重，发病率日渐增多，且有低龄化的趋势([1]张春和,李焱风,秦国政,申吉泓,徐波,赵凡,张富刚,杨毅坚,陈天波,丁世霖,邹建东.前列通窍胶囊治疗肾虚瘀阻型前列腺增生症87例临床研究[J].中华中医药杂志,2016,31(10):4299-4302)。前列腺增生病程进展缓慢，由于病变的程度不一定伴随临床症状变化，所以难以确定起病时间。早期的前列腺增生由于人体的代偿功能，症状可能不明显。随着前列腺增生程度加重，症状逐渐明显，临床症状包括尿频、尿等待、尿滴沥、夜尿增多、排尿困难等。目前治疗前列腺增生的有效方法主要是通过药物或者手术治疗。由于手术治疗前列腺增生具有一定后遗症和风险性，服用西药治疗则副作用明显，依赖性强，耐药性大。中医药的防治在此则较有明显的优势([2]佟志刚,王丽新.中医治疗前列腺增生的临床疗效分析[J].中国医药指南,2014,12(21):270-271)。
首先，中医临床认为肾虚是前列腺增生发病的基本病因([3]童亮,汤进,阳辉辉,周益红,刘旺,戴英波.补肾通关颗粒治疗BPH患者临床疗效分析[J].中药材,2017,40(02):482-484)：本病好发于老年男性，源于男子40岁以后，激素调节功能失衡，肾气逐渐衰减。肾主水液，体内水液的分布与排泄，主要靠肾的气化作用。肾气不足,气化无力，津液不能正常的下输水道，关门开阖不利，则可发生癃闭。其次，痰瘀是前列腺增生主要的病理产物([4]张春和,李焱风,秦国政,陈天波,张富刚,丁世霖,杨毅坚.540例良性前列腺增生症患者中医证候分布规律研究[J].中医杂志,2012,53(01):45-47)：老年人肾阳不足，脾胃运化能力减弱，导致水液输布失常，凝而成痰，甚至影响到气血的运行，从而瘀堵于血脉中。即前列腺增生乃为痰瘀拥堵于下焦，水道不利，则发为癃闭。最后，热毒内蕴是前列腺增生的主要兼证([5]孙自学,宋春生,邢俊平,毛向明,李湛民,郝高利.良性前列腺增生中西医结合诊疗指南(试行版)[J].中华男科学杂志,2017,23(03):280-285)：由膀胱与肾俱有热，热气太盛入于胞，故令结涩，发为小便不通。所以前列腺增生患者出现小便不通多因湿浊败精，郁久化热，蕴热成毒阻于尿道，导致小便不通而癃闭。
发明内容
本发明的目的在于提供一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比由以下原料组成：
巴戟天10～20、浙贝母10～20、玄参15～20、虎杖10～20、赤小豆15～30、怀牛膝10～20。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比可由以下原料组成：
巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比可由以下原料组成：
巴戟天20、浙贝母10、玄参10、虎杖10、赤小豆30、怀牛膝15。
所述治疗肾虚痰热证前列腺增生的中药复方的制备方法包括以下步骤：
1)按组成原料混合，放入煎药容器中，再加入水，浸泡，先用武火煮沸后，再改文火煎煮，得药液；
2)用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；
3)两次煎煮得到的滤液混合后即为内服药物。
在步骤1)中，所述水的加入量可为600～1000mL；所述浸泡时间可为30～60min；所述文火煎煮的时间可为20～30min，所述文火煎煮的过程中可搅拌2～3次。
在步骤2)中，所述文火煎煮的时间可为20～30min，所述文火煎煮的过程中可搅拌2～3次。
所述治疗肾虚痰热证前列腺增生的中药复方的剂型可为汤剂、丸剂、散剂、片剂、膏剂、颗粒剂、胶囊剂、口服液等中的一种。
所得内服药物的用法为：每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
以下给出本发明所述治疗肾虚痰热证前列腺增生的中药复方的原料药药理：
巴戟天：别名巴戟、巴吉天、戟天、巴戟肉、鸡肠风、猫肠筋、兔儿肠、鸡眼藤、黑藤钻、糠藤、三角藤、不雕草、三蔓草。性微温，味辛、甘。归肝、肾经。功效：补肾助阳、强筋壮骨、祛风除湿。主治：肾虚阳痿，遗精早泄，少腹冷痛，小便不禁，宫冷不孕，风寒湿痹，腰膝酸软，风湿肢气等。
浙贝母：别名别名浙贝、大贝、象贝、元宝贝、珠贝。性寒，味苦。归肺、心经。功效：清热化痰，散结解毒。治风热咳嗽，肺痈喉痹，瘰疬，疮疡肿毒等。
玄参：别名重台、鬼藏、正马、鹿肠、端、玄台、逐马、馥草、黑参、野脂麻、元参。性微寒、味苦。归肺、肾经。功效：滋阴降火，除烦解毒。主治：热病伤阴，舌绎烦渴，发斑，骨蒸劳热，夜寐不宁，自汗盗汗，津伤便秘，吐血衄血，咽喉肿痛，痈肿，瘰疬，温毒发斑、目赤、白喉、疮毒等。
虎杖：别名大虫杖、苦杖、酸杖、斑杖、酸桶笋、斑庄根、鸟不踏、酸杆、斑根、酸榴根、土地檎、酸通、雄黄连、蛇总管、大活血、血藤、紫金龙、酸汤秆、黄地榆、号筒草、斑龙紫、野黄连、活血丹、红贯脚、阴阳莲、活血龙、猴竹。性平，味苦。归肝、胆、肺经。功效：祛风利湿，破瘀通经。主治：风湿筋骨疼痛，湿热黄疸，淋浊带下，妇女经闭，产后恶露不下，症瘕积聚，痔漏下血。跌扑损伤，烫伤，恶疮癣疾泻下攻积、泻火解毒、活血祛瘀、清泄湿热等。
赤小豆：别名亦豆、红豆、红小豆、小红绿豆、虱拇豆、朱赤豆、金红小豆、朱小豆。性平，味甘酸。归心、小肠经。功效：利水除湿，和血排脓，消肿解毒。主治：治水肿，脚气，黄疸，泻痢，便血，痈肿等。
怀牛膝：别名牛膝、牛髁膝、山苋菜、对节草、红牛膝、杜牛膝、土牛膝。性平，味甘苦酸。归肝、肾经。功效：补肝肾，强筋骨，逐瘀通经，引血下行。主治：腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕等。
所述巴戟天为君药，浙贝母和玄参为臣药，虎杖和赤小豆为佐药，怀牛膝为佐使药。
本发明以巴戟天、浙贝母、玄参、虎杖、赤小豆、怀牛膝组成，方中巴戟天味甘、辛，其性微温，归于肾、肝经，善于温补肾阳，填精化气，又兼能祛湿为君药。浙贝母味苦，其性寒，入肺、心经，该药具有清热化痰散结，消除癥结肿块之功效，能清肺开壅，提壶揭盖，可通淋闭；玄参味甘、苦、咸，其性微寒，可入肺、胃、肾经，该药能清热解毒散结，且玄参能制约方中温燥之药，二者共用为臣药。虎杖、赤小豆可以清热解毒，利水除湿，且虎杖还兼有散瘀化痰之功效，二者同为佐药。再佐以怀牛膝，其味苦、酸，性平，入肝、肾经，主要具备补肾之功效，同时又可活血祛瘀通经，又因怀牛膝能引诸药之力下行到达病灶，兼为佐使药。全方共奏补肾化痰，清热散结，通络利水的功效。且是纯中药制剂，无明显依赖性，不易复发。
具体实施方式
以下实施例将对本发明作进一步的说明。
实施例1：一种治疗肾虚痰热证前列腺增生的中药复方，包括以下原料制备得到：巴戟天15份、浙贝母15份、玄参15份、虎杖15份、赤小豆20份、怀牛膝15份。
制备方法：按配方称取药材，将称取的药材混合均匀，洗净后放入煎药容器中，再加入600～1000mL的纯净水，混合均匀，浸泡30～60min。用武火煮沸后，再改文火煎煮20～30min，煎药过程中可适当搅拌2～3次。用过滤纱布倒取滤液于药液容器中，再加入适量纯净水于煎药容器中至没过药物，煎煮方法同上，再次倒取滤液于药液容器中。两次煎煮获取的滤液混合后即为内服药物。每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
实施例2：一种治疗肾虚痰热证前列腺增生的中药复方，包括以下原料制备得到：巴戟天20份、浙贝母10份、玄参10份、虎杖10份、赤小豆30份、怀牛膝15份。
效果：上述药物互相协调合作，可以达到有效治疗肾虚痰热证前列腺增生的效果，且无依赖性。
以下给出临床实例：
1、患者王某，男，74岁，尿频、排尿困难5年余，于2017年12月25日来我院就诊，自诉5年多以来，尿频，排尿困难，有时频数短涩，现症见：小便点滴不通，夜尿增多，每夜5～6次，偶有浑浊尿，腰膝酸软，口干口苦，大便干结，舌暗红苔黄，脉沉数。检查：B超印象为前列腺腺体肿大。最大尿流率11.3mL/s。结合临床，本患者可诊断前列腺增生。使用本发明实施例1所制中药汤剂，每日一剂，一天两次，连服15日。2018年1月11日复诊，诉排尿困难的症状有缓解，夜尿3～4次，其余症状有不同程度的减轻。效不更方，再取原方续服30天。三诊：2018年02月20日，患者自觉尿频、排尿困难症状很大程度减轻，夜尿减少至2次，B超检查，前列腺较前略有缩小。最大尿流率16.9mL/s。
2、患者何某，男，57岁。尿频尿急，夜间遗尿6年余，在某医院诊断为前列腺增生，2017年11月7号来我院就诊，现症见：尿频尿急，腰膝酸软，舌淡暗苔薄黄，脉沉稍数。使用本发明实施例2所制中药胶囊剂，每日一剂，一天两次，15日为一疗程。1个疗程后症状明显减轻，继续治疗两个疗程症状则完全消失。
3、患者连某，男，45岁。尿频，滴沥不尽，性功能减退两年余，时轻时重，夜寐欠安，在我院做B超显示，前列腺4.6cm×5.1cm×4.0cm。服用本发明实施例2所制颗粒剂1个疗程后明显感觉症状好转，夜里睡眠质量改善。后又连续服用2个疗程，症状明显减轻。再次服用2个疗程加强治疗，随访至今没有复发。
Claims (7)
1.一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于按质量比由以下原料组成：
巴戟天10～20、浙贝母10～20、玄参15～20、虎杖10～20、赤小豆15～30、怀牛膝10～20。
2.如权利要求1所述一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于所述治疗肾虚痰热证前列腺增生的中药复方按质量比由以下原料组成：
巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。
3.如权利要求1所述一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于其剂型为汤剂、丸剂、散剂、片剂、膏剂、颗粒剂、胶囊剂、口服液中的一种。
4.如权利要求1～3任一项所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于包括以下步骤：
1）按组成原料混合，放入煎药容器中，再加入水600～1000mL，浸泡30～60min，先用武火煮沸后，再改文火煎煮，得药液；
2）用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；
3）两次煎煮得到的滤液混合后即为内服药物。
5.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1）中，所述文火煎煮的时间为20～30min。
6.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1）中，所述文火煎煮的过程中搅拌2～3次。
7.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤2）中，所述文火煎煮的时间为20～30min，所述文火煎煮的过程中搅拌2～3次。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810499630.6A CN108355045B (zh) | 2018-05-23 | 2018-05-23 | 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810499630.6A CN108355045B (zh) | 2018-05-23 | 2018-05-23 | 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108355045A CN108355045A (zh) | 2018-08-03 |
| CN108355045B true CN108355045B (zh) | 2021-01-01 |
Family
ID=63012314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810499630.6A Active CN108355045B (zh) | 2018-05-23 | 2018-05-23 | 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108355045B (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125911A (zh) * | 2015-09-06 | 2015-12-09 | 江淑芬 | 一种用于调治前列腺增生的中药组合物及其制备方法 |
| US9498508B2 (en) * | 2013-03-11 | 2016-11-22 | Mingchun Xiao | Pharmaceutical composition for treating cancers and preparation method therefor |
-
2018
- 2018-05-23 CN CN201810499630.6A patent/CN108355045B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9498508B2 (en) * | 2013-03-11 | 2016-11-22 | Mingchun Xiao | Pharmaceutical composition for treating cancers and preparation method therefor |
| CN105125911A (zh) * | 2015-09-06 | 2015-12-09 | 江淑芬 | 一种用于调治前列腺增生的中药组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 徐福松教授治疗前列腺增生用药经验拾零;薛玉书;《四川中医》;20001015;4-5 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108355045A (zh) | 2018-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100518807C (zh) | 一种治疗肝硬化腹水的药物 | |
| CN101081261B (zh) | 一种治疗痔疮的药物 | |
| CN102512630B (zh) | 一种治疗胆囊结石的中药组合物 | |
| CN101549069A (zh) | 抗淋巴癌药品使用及生产方法 | |
| CN101129994A (zh) | 一种治疗黄疸的中药组合物 | |
| CN104288701A (zh) | 一种治疗胆囊炎的中药组合物 | |
| CN102512632B (zh) | 一种治疗月经不调的中药组合物 | |
| CN101695555B (zh) | 治疗前列腺炎、前列腺增生的药物组合物及其制备方法 | |
| CN106390077A (zh) | 一种治疗腹痛、腹泻的药物组合物及其制备方法和应用 | |
| CN108355045B (zh) | 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 | |
| CN113288939A (zh) | 一种护肾沐足中药组合物及其制备方法 | |
| CN101658652A (zh) | 一种治疗慢性阑尾炎的中药制剂 | |
| CN105287949A (zh) | 一种治疗痛经的中药组合物 | |
| CN104758754A (zh) | 一种治疗肾气虚衰型前列腺增生的药物及制备方法 | |
| CN104189268A (zh) | 一种治疗产后月经不调的中药制剂 | |
| CN104825892B (zh) | 一种治疗排卵期出血的中药制剂及其制备方法 | |
| CN102205075B (zh) | 治疗乳腺病的外用药膏组合物的制备方法及其应用 | |
| CN101961481A (zh) | 一种治疗肝胆气郁型胆囊炎的中药及其制备方法 | |
| CN101376017A (zh) | 一种治疗便秘的中药及其制作方法 | |
| CN105902878A (zh) | 一种治疗尿路结石的药物及其制备 | |
| CN106309576A (zh) | 一种治疗痔疮的药物及其制备方法 | |
| CN104758444A (zh) | 一种治疗银屑病的中药组合物 | |
| CN104547672A (zh) | 用于预防痔疮发作和治疗痔疮的中药组合物 | |
| CN108785611A (zh) | 一种用于治疗肿瘤的中药及制备方法 | |
| CN117045740A (zh) | 一种调理便秘的脐疗配方及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181102 Address after: 361004 201-209 Hubin South Road, Siming District, Xiamen, Fujian Applicant after: Zhongshan Hospital Xiamen University Applicant after: Xiamen University Address before: Xiamen City, Fujian Province, 361005 South Siming Road No. 422 Applicant before: Xiamen University |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |