CN108355045A - 一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 - Google Patents
一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法 Download PDFInfo
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Abstract
一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法，涉及中药复方。中药复方按质量比可由以下原料组成：巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。按组成原料混合，放入煎药容器中，再加入水，浸泡，先用武火煮沸后，再改文火煎煮，得药液；用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；两次煎煮得到的滤液混合后即为内服药物。所得内服药物的用法为：每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
Description
技术领域
本发明涉及中药复方，尤其涉及一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法。
背景技术
前列腺增生(BPH)是男性中老年人常见的泌尿系统疾病之一，随生活压力日渐加重，发病率日渐增多，且有低龄化的趋势([1]张春和,李焱风,秦国政,申吉泓,徐波,赵凡,张富刚,杨毅坚,陈天波,丁世霖,邹建东.前列通窍胶囊治疗肾虚瘀阻型前列腺增生症87例临床研究[J].中华中医药杂志,2016,31(10):4299-4302)。前列腺增生病程进展缓慢，由于病变的程度不一定伴随临床症状变化，所以难以确定起病时间。早期的前列腺增生由于人体的代偿功能，症状可能不明显。随着前列腺增生程度加重，症状逐渐明显，临床症状包括尿频、尿等待、尿滴沥、夜尿增多、排尿困难等。目前治疗前列腺增生的有效方法主要是通过药物或者手术治疗。由于手术治疗前列腺增生具有一定后遗症和风险性，服用西药治疗则副作用明显，依赖性强，耐药性大。中医药的防治在此则较有明显的优势([2]佟志刚,王丽新.中医治疗前列腺增生的临床疗效分析[J].中国医药指南,2014,12(21):270-271)。
首先，中医临床认为肾虚是前列腺增生发病的基本病因([3]童亮,汤进,阳辉辉,周益红,刘旺,戴英波.补肾通关颗粒治疗BPH患者临床疗效分析[J].中药材,2017,40(02):482-484)：本病好发于老年男性，源于男子40岁以后，激素调节功能失衡，肾气逐渐衰减。肾主水液，体内水液的分布与排泄，主要靠肾的气化作用。肾气不足,气化无力，津液不能正常的下输水道，关门开阖不利，则可发生癃闭。其次，痰瘀是前列腺增生主要的病理产物([4]张春和,李焱风,秦国政,陈天波,张富刚,丁世霖,杨毅坚.540例良性前列腺增生症患者中医证候分布规律研究[J].中医杂志,2012,53(01):45-47)：老年人肾阳不足，脾胃运化能力减弱，导致水液输布失常，凝而成痰，甚至影响到气血的运行，从而瘀堵于血脉中。即前列腺增生乃为痰瘀拥堵于下焦，水道不利，则发为癃闭。最后，热毒内蕴是前列腺增生的主要兼证([5]孙自学,宋春生,邢俊平,毛向明,李湛民,郝高利.良性前列腺增生中西医结合诊疗指南(试行版)[J].中华男科学杂志,2017,23(03):280-285)：由膀胱与肾俱有热，热气太盛入于胞，故令结涩，发为小便不通。所以前列腺增生患者出现小便不通多因湿浊败精，郁久化热，蕴热成毒阻于尿道，导致小便不通而癃闭。
发明内容
本发明的目的在于提供一种治疗肾虚痰热证前列腺增生的中药复方及其制备方法。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比由以下原料组成：
巴戟天10～20、浙贝母10～20、玄参15～20、虎杖10～20、赤小豆15～30、怀牛膝10～20。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比可由以下原料组成：
巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。
所述治疗肾虚痰热证前列腺增生的中药复方按质量比可由以下原料组成：
巴戟天20、浙贝母10、玄参10、虎杖10、赤小豆30、怀牛膝15。
所述治疗肾虚痰热证前列腺增生的中药复方的制备方法包括以下步骤：
1)按组成原料混合，放入煎药容器中，再加入水，浸泡，先用武火煮沸后，再改文火煎煮，得药液；
2)用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；
3)两次煎煮得到的滤液混合后即为内服药物。
在步骤1)中，所述水的加入量可为600～1000mL；所述浸泡时间可为30～60min；所述文火煎煮的时间可为20～30min，所述文火煎煮的过程中可搅拌2～3次。
在步骤2)中，所述文火煎煮的时间可为20～30min，所述文火煎煮的过程中可搅拌2～3次。
所述治疗肾虚痰热证前列腺增生的中药复方的剂型可为汤剂、丸剂、散剂、片剂、膏剂、颗粒剂、胶囊剂、口服液等中的一种。
所得内服药物的用法为：每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
以下给出本发明所述治疗肾虚痰热证前列腺增生的中药复方的原料药药理：
巴戟天：别名巴戟、巴吉天、戟天、巴戟肉、鸡肠风、猫肠筋、兔儿肠、鸡眼藤、黑藤钻、糠藤、三角藤、不雕草、三蔓草。性微温，味辛、甘。归肝、肾经。功效：补肾助阳、强筋壮骨、祛风除湿。主治：肾虚阳痿，遗精早泄，少腹冷痛，小便不禁，宫冷不孕，风寒湿痹，腰膝酸软，风湿肢气等。
浙贝母：别名别名浙贝、大贝、象贝、元宝贝、珠贝。性寒，味苦。归肺、心经。功效：清热化痰，散结解毒。治风热咳嗽，肺痈喉痹，瘰疬，疮疡肿毒等。
玄参：别名重台、鬼藏、正马、鹿肠、端、玄台、逐马、馥草、黑参、野脂麻、元参。性微寒、味苦。归肺、肾经。功效：滋阴降火，除烦解毒。主治：热病伤阴，舌绎烦渴，发斑，骨蒸劳热，夜寐不宁，自汗盗汗，津伤便秘，吐血衄血，咽喉肿痛，痈肿，瘰疬，温毒发斑、目赤、白喉、疮毒等。
虎杖：别名大虫杖、苦杖、酸杖、斑杖、酸桶笋、斑庄根、鸟不踏、酸杆、斑根、酸榴根、土地檎、酸通、雄黄连、蛇总管、大活血、血藤、紫金龙、酸汤秆、黄地榆、号筒草、斑龙紫、野黄连、活血丹、红贯脚、阴阳莲、活血龙、猴竹。性平，味苦。归肝、胆、肺经。功效：祛风利湿，破瘀通经。主治：风湿筋骨疼痛，湿热黄疸，淋浊带下，妇女经闭，产后恶露不下，症瘕积聚，痔漏下血。跌扑损伤，烫伤，恶疮癣疾泻下攻积、泻火解毒、活血祛瘀、清泄湿热等。
赤小豆：别名亦豆、红豆、红小豆、小红绿豆、虱拇豆、朱赤豆、金红小豆、朱小豆。性平，味甘酸。归心、小肠经。功效：利水除湿，和血排脓，消肿解毒。主治：治水肿，脚气，黄疸，泻痢，便血，痈肿等。
怀牛膝：别名牛膝、牛髁膝、山苋菜、对节草、红牛膝、杜牛膝、土牛膝。性平，味甘苦酸。归肝、肾经。功效：补肝肾，强筋骨，逐瘀通经，引血下行。主治：腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕等。
所述巴戟天为君药，浙贝母和玄参为臣药，虎杖和赤小豆为佐药，怀牛膝为佐使药。
本发明以巴戟天、浙贝母、玄参、虎杖、赤小豆、怀牛膝组成，方中巴戟天味甘、辛，其性微温，归于肾、肝经，善于温补肾阳，填精化气，又兼能祛湿为君药。浙贝母味苦，其性寒，入肺、心经，该药具有清热化痰散结，消除癥结肿块之功效，能清肺开壅，提壶揭盖，可通淋闭；玄参味甘、苦、咸，其性微寒，可入肺、胃、肾经，该药能清热解毒散结，且玄参能制约方中温燥之药，二者共用为臣药。虎杖、赤小豆可以清热解毒，利水除湿，且虎杖还兼有散瘀化痰之功效，二者同为佐药。再佐以怀牛膝，其味苦、酸，性平，入肝、肾经，主要具备补肾之功效，同时又可活血祛瘀通经，又因怀牛膝能引诸药之力下行到达病灶，兼为佐使药。全方共奏补肾化痰，清热散结，通络利水的功效。且是纯中药制剂，无明显依赖性，不易复发。
具体实施方式
以下实施例将对本发明作进一步的说明。
实施例1：一种治疗肾虚痰热证前列腺增生的中药复方，包括以下原料制备得到：巴戟天15份、浙贝母15份、玄参15份、虎杖15份、赤小豆20份、怀牛膝15份。
制备方法：按配方称取药材，将称取的药材混合均匀，洗净后放入煎药容器中，再加入600～1000mL的纯净水，混合均匀，浸泡30～60min。用武火煮沸后，再改文火煎煮20～30min，煎药过程中可适当搅拌2～3次。用过滤纱布倒取滤液于药液容器中，再加入适量纯净水于煎药容器中至没过药物，煎煮方法同上，再次倒取滤液于药液容器中。两次煎煮获取的滤液混合后即为内服药物。每日一剂，分早、晚两次服用，15天为一疗程，一般1～3个疗程即可治愈。
实施例2：一种治疗肾虚痰热证前列腺增生的中药复方，包括以下原料制备得到：巴戟天20份、浙贝母10份、玄参10份、虎杖10份、赤小豆30份、怀牛膝15份。
效果：上述药物互相协调合作，可以达到有效治疗肾虚痰热证前列腺增生的效果，且无依赖性。
以下给出临床实例：
1、患者王某，男，74岁，尿频、排尿困难5年余，于2017年12月25日来我院就诊，自诉5年多以来，尿频，排尿困难，有时频数短涩，现症见：小便点滴不通，夜尿增多，每夜5～6次，偶有浑浊尿，腰膝酸软，口干口苦，大便干结，舌暗红苔黄，脉沉数。检查：B超印象为前列腺腺体肿大。最大尿流率11.3mL/s。结合临床，本患者可诊断前列腺增生。使用本发明实施例1所制中药汤剂，每日一剂，一天两次，连服15日。2018年1月11日复诊，诉排尿困难的症状有缓解，夜尿3～4次，其余症状有不同程度的减轻。效不更方，再取原方续服30天。三诊：2018年02月20日，患者自觉尿频、排尿困难症状很大程度减轻，夜尿减少至2次，B超检查，前列腺较前略有缩小。最大尿流率16.9mL/s。
2、患者何某，男，57岁。尿频尿急，夜间遗尿6年余，在某医院诊断为前列腺增生，2017年11月7号来我院就诊，现症见：尿频尿急，腰膝酸软，舌淡暗苔薄黄，脉沉稍数。使用本发明实施例2所制中药胶囊剂，每日一剂，一天两次，15日为一疗程。1个疗程后症状明显减轻，继续治疗两个疗程症状则完全消失。
3、患者连某，男，45岁。尿频，滴沥不尽，性功能减退两年余，时轻时重，夜寐欠安，在我院做B超显示，前列腺4.6cm×5.1cm×4.0cm。服用本发明实施例2所制颗粒剂1个疗程后明显感觉症状好转，夜里睡眠质量改善。后又连续服用2个疗程，症状明显减轻。再次服用2个疗程加强治疗，随访至今没有复发。
Claims (10)
1.一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于按质量比由以下原料组成：
巴戟天10～20、浙贝母10～20、玄参15～20、虎杖10～20、赤小豆15～30、怀牛膝10～20。
2.如权利要求1所述一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于所述治疗肾虚痰热证前列腺增生的中药复方按质量比由以下原料组成：
巴戟天15、浙贝母15、玄参15、虎杖15、赤小豆20、怀牛膝15。
3.如权利要求1所述一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于所述治疗肾虚痰热证前列腺增生的中药复方按质量比由以下原料组成：
巴戟天20、浙贝母10、玄参10、虎杖10、赤小豆30、怀牛膝15。
4.如权利要求1～3所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于包括以下步骤：
1)按组成原料混合，放入煎药容器中，再加入水，浸泡，先用武火煮沸后，再改文火煎煮，得药液；
2)用过滤纱布倒取滤液于药液容器中，再加入水于煎药容器中至没过药物，再先用武火煮沸后，改文火煎煮，再次倒取滤液于药液容器中；
3)两次煎煮得到的滤液混合后即为内服药物。
5.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1)中，所述水的加入量为600～1000mL。
6.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1)中，所述浸泡的时间为30～60min。
7.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1)中，所述文火煎煮的时间为20～30min。
8.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤1)中，所述文火煎煮的过程中搅拌2～3次。
9.如权利要求4所述治疗肾虚痰热证前列腺增生的中药复方的制备方法，其特征在于在步骤2)中，所述文火煎煮的时间为20～30min，所述文火煎煮的过程中搅拌2～3次。
10.如权利要求1所述一种治疗肾虚痰热证前列腺增生的中药复方，其特征在于其剂型为汤剂、丸剂、散剂、片剂、膏剂、颗粒剂、胶囊剂、口服液中的一种。
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