WO2014117316A1 - 多功能芦荟胶及其制备方法 - Google Patents
多功能芦荟胶及其制备方法 Download PDFInfo
- Publication number
- WO2014117316A1 WO2014117316A1 PCT/CN2013/001490 CN2013001490W WO2014117316A1 WO 2014117316 A1 WO2014117316 A1 WO 2014117316A1 CN 2013001490 W CN2013001490 W CN 2013001490W WO 2014117316 A1 WO2014117316 A1 WO 2014117316A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sodium hyaluronate
- aloe vera
- multifunctional
- betaine
- vera gel
- Prior art date
Links
- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 55
- 241001116389 Aloe Species 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000001879 gelation Methods 0.000 title abstract description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 46
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 46
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 42
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 40
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 38
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 32
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 30
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 29
- 229960003237 betaine Drugs 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 17
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 16
- 239000011703 D-panthenol Substances 0.000 claims abstract description 16
- 235000004866 D-panthenol Nutrition 0.000 claims abstract description 16
- 229960000458 allantoin Drugs 0.000 claims abstract description 16
- 229960003949 dexpanthenol Drugs 0.000 claims abstract description 16
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 15
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 15
- 229960001631 carbomer Drugs 0.000 claims abstract description 15
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940041616 menthol Drugs 0.000 claims abstract description 14
- 239000003755 preservative agent Substances 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims abstract description 9
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 229940064064 purslane extract Drugs 0.000 claims abstract description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract 6
- 230000001804 emulsifying effect Effects 0.000 claims abstract 4
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 41
- 238000003756 stirring Methods 0.000 claims description 25
- 229920000642 polymer Polymers 0.000 claims description 9
- 239000002537 cosmetic Substances 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- 239000003513 alkali Substances 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 7
- 235000019634 flavors Nutrition 0.000 claims description 7
- 238000004945 emulsification Methods 0.000 claims description 6
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 claims description 3
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 claims description 3
- 244000144927 Aloe barbadensis Species 0.000 claims 8
- 240000001592 Amaranthus caudatus Species 0.000 claims 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims 1
- 235000012735 amaranth Nutrition 0.000 claims 1
- 239000004178 amaranth Substances 0.000 claims 1
- 230000006862 enzymatic digestion Effects 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 abstract description 13
- 238000001816 cooling Methods 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract 2
- 238000013019 agitation Methods 0.000 abstract 1
- NMJJFJNHVMGPGM-UHFFFAOYSA-N butyl formate Chemical compound CCCCOC=O NMJJFJNHVMGPGM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 244000186892 Aloe vera Species 0.000 description 33
- 210000003491 skin Anatomy 0.000 description 29
- 230000003020 moisturizing effect Effects 0.000 description 16
- 230000000694 effects Effects 0.000 description 12
- 235000001855 Portulaca oleracea Nutrition 0.000 description 9
- 244000234609 Portulaca oleracea Species 0.000 description 7
- 230000003110 anti-inflammatory effect Effects 0.000 description 7
- -1 compound sodium hyaluronate Chemical class 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000008176 lyophilized powder Substances 0.000 description 5
- 230000003266 anti-allergic effect Effects 0.000 description 4
- 230000003796 beauty Effects 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229940014041 hyaluronate Drugs 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000219304 Portulacaceae Species 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- CZMOVKLQUFOJAZ-UHFFFAOYSA-N butyl n-(3-iodoprop-1-ynyl)carbamate Chemical compound CCCCOC(=O)NC#CCI CZMOVKLQUFOJAZ-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SKKTUOZKZKCGTB-UHFFFAOYSA-N butyl carbamate Chemical compound CCCCOC(N)=O SKKTUOZKZKCGTB-UHFFFAOYSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- the invention relates to aloe vera gel, in particular to a multifunctional aloe vera gel and a preparation method thereof. Background technique
- hyaluronate Polyols such as 1,3-butanediol, and a natural moisturizing factor with unique water-keeping and lubricating properties, sodium hyaluronate are usually added to high-end cosmetics.
- the commonly used hyaluronic acid is a high molecular hyaluronic acid having a molecular weight of several hundred thousand to more than one million. It is difficult to achieve multiple moisturizing effects that satisfy consumers by adding only common translucent acid.
- the present invention provides a multifunctional aloe vera gel which is mild in nature, safe to use, and has superior skin care and beauty effects, and a preparation method thereof.
- the technical solution adopted by the present invention to solve the technical problems thereof is as follows: Multifunctional aloe vera gel, including the following components by weight percentage:
- Aloe freeze-dried powder 0.10 ⁇ 1.50%, Portulaca oleracea extract 0.00% ⁇ 10.00%, polymer sodium hyaluronate 0.00% ⁇ 1.00%, oligomeric sodium hyaluronate 0.00% ⁇ 1.00%, allantoin 0.00% ⁇ 0.40%, D-panthenol 0.00% ⁇ 5.00%, betaine 0.00% ⁇ 5.00%, ⁇ -glucan 0.10% ⁇ 3.00%, 1,3-butanediol 1.00% ⁇ 15.00%, menthol 0.00% ⁇ 1.00%, carbomer 0.10% ⁇ 2.00%, flavor 0.00%-0.30%, preservative 0.00% ⁇ 0.30%, lye 0.10% ⁇ 10.00%, deionized water 10.00% ⁇ 90.00%.
- the multifunctional aloe vera gel wherein the oligomeric sodium hyaluronate is a low molecular weight sodium hyaluronate having a molecular weight of 3000-10000 obtained by enzymatic cleavage.
- a multifunctional aloe vera gel the betaine being a cosmetic or pharmaceutical grade betaine.
- a multifunctional aloe vera gel the preservative being one or a mixture of methyl isothiazolinone and iodopropynyl butyl carbamate.
- a multifunctional aloe vera gel the lye being one of potassium hydroxide or sodium hydroxide solution.
- a multifunctional aloe vera gel, the lye being one of a concentration of 5% potassium hydroxide or sodium hydroxide solution.
- the preparation method of the multifunctional aloe vera gel comprises the following steps:
- B dissolve the aloe lyophilized powder with the amount of water, and use it;
- C polymer sodium hyaluronate, oligo-sodium hyaluronate, deionized water, allantoin, D-panthenol, betaine, ⁇ -glucan, carbomer are respectively put into the emulsification pot, vacuumed, 30 rpm / 50 ° rpm, mixing and stirring, while heating to 70 ° C temperature, control the heating, continue to stir until completely dissolved, cooled to a temperature of 50 ⁇ , added to the ⁇ step of the product and purslane extraction Object, vacuum, 30 rpm, stirring, continue cooling until the temperature drops below 45 ;;
- the multifunctional aloe vera gel according to the invention comprises aloe lyophilized powder, plant extract, sodium hyaluronate, allantoin, D-panthenol, menthol, betaine, 3 - Effective active ingredients such as dextran are a kind of mild skin care, safe to use, have superior moisturizing properties, can be used alone to play the skin care effect of aloe vera, and can be used in combination with other skin care products to play aloe vera.
- aloe vera has the functions of sunscreen, moisturizing, analgesic, antibacterial and anti-inflammatory, preventing acne, healing superficial wounds, etc.; purslane extract has anti-allergic, anti-irritant, anti-inflammatory and acne effects.
- the compound sodium hyaluronate is a mixture of high molecular weight sodium hyaluronate and sodium oligo-sodium hyaluronate.
- the high-molecular hyaluronate has good film-forming properties, can lock the surface moisture of the skin, tighten the skin, and Poly-hyaluronate has a fast penetration, deep moisturizing, reducing skin wrinkles, etc.; It has the functions of moisturizing, anti-wrinkle, softening keratin, stimulating tissue growth and promoting wound healing;
- D-panthenol has anti-inflammatory, moisturizing and wound healing effects; menthol has antipruritic, anti-allergic, anti-inflammatory, anti-inflammatory and anti-bacterial effects; betaine can improve skin's moisture retention, stimulate cell vitality, and maintain skin Moisturizing, smooth, preventing dryness and darkening effect; while ⁇ -glucan has the functions of moisturizing, anti-aging, anti-allergy, anti-inflammatory, anti-ultraviolet damage, promoting scar healing and regeneration, and multiple components can be used simultaneously. Give full play to the unique effects of each component and ensure the best results of the overall product. detailed description
- Multi-functional aloe vera gel by weight, includes the following components:
- aloe vera freeze-dried powder uses Aloe vera freeze-dried powder as the main functional raw material, and the aloe vera, amino acid, mucopolysaccharide and other active ingredients contained in the aloe have superior skin care and beauty effects;
- the multi-functional aloe vera gel of the invention is sterilized, anti-inflammatory, anti-allergic, anti-aging and promotes the healing of damaged skin by the compounding of various active ingredients such as purslane extract, D-panthenol and ⁇ -glucan. The effect is enhanced, which can increase the damage of the skin to the outside.
- the resistance of the bacteria promotes the proliferation of epidermal cells and contributes to skin regeneration in the damaged area.
- the present invention selects two different molecular weights of sodium hyaluronate - high molecular weight sodium hyaluronate and sodium oligo-sodium hyaluronate as a humectant, and the high molecular weight sodium hyaluronate molecule can be
- the surface of the skin forms a permeable hydrated membrane, which softens the hydrated layer of the stratum corneum and increases the absorption and utilization of the active substance by the stratum corneum.
- the oligomeric sodium hyaluronate can directly penetrate into the dermis, expand the capillaries, increase blood microcirculation, and strengthen nutrition.
- the supply of materials through the cooperation of the two, achieves a more comprehensive, three-dimensional moisturizing effect.
- the 1,3-butanediol, allantoin and betaine added in the present invention can absorb moisture from the atmosphere and the skin to keep the skin moisturized, and improve the skin's moisture retention, thereby further improving the water absorption and water retention effect.
- 1, 3-butanediol also has a good antibacterial effect.
- the invention selects carbomer as a gelling agent, has the characteristics of water-soluble matrix, has rapid drug release, is non-greasy, and has no irritation to skin and mucous membrane. When used, it can form a protective film on the surface of the skin to isolate foreign pollutants. Invasion of the skin.
- the present invention selects one of potassium hydroxide or sodium hydroxide solution having a concentration of 5% as a neutralizing agent.
- the acidic carbomer is salted, and the curled molecules are opened and thickened to adjust the stability and viscosity of the preparation.
- the invention uses methyl isothiazolinone in combination with butyl iodopropynylcarbamate, which can effectively prevent spoilage and secondary pollution of cosmetics during the effective period, so as to ensure product safety. Sex and stability.
- the multifunctional aloe vera gel according to the invention has stable properties and good compatibility, and the gel tissue is fine and uniform, free from foreign matter, and conforms to the prescribed aroma, and does not cause delamination even under high temperature and low temperature conditions.
- its pH, bacterial content and heavy metal content are in line with the quality requirements of skin care products.
- the oligomeric sodium hyaluronate is a low molecular weight sodium hyaluronate having a molecular weight of 3000-10000 prepared by enzymatic cleavage; basically only high molecular weight hyaluronic acid is used in ordinary skin care and beauty products.
- Nano selects two different molecular weights of sodium hyaluronate - high molecular weight sodium hyaluronate and oligomeric sodium hyaluronate as a humectant, high molecular weight sodium hyaluronate molecules can form a breathable surface
- the hydrated membrane softens the hydrated layer of the stratum corneum and increases the absorption and utilization of the active substance by the stratum corneum.
- the oligomeric sodium hyaluronate can directly penetrate into the dermis layer, expand the capillaries, increase the blood microcirculation, and strengthen the supply of nutrients. The two work together to achieve a more comprehensive, three-dimensional moisturizing effect.
- Multi-functional aloe vera gel which is a cosmetic or pharmaceutical grade betaine.
- Betaine can improve the skin's moisture retention and stimulate cell vitality, and has the effect of keeping skin moist, smooth, dry and dark.
- the preservative is one or a mixture of methyl isothiazolinone and butyl iodopropynyl carbamate; the invention combines methyl isothiazolinone with iodopropynyl group
- the use of butyl carbamate can effectively prevent the spoilage and secondary pollution of cosmetics during the effective period to ensure the safety and stability of the product;
- the lye is one of a concentration of 5% potassium hydroxide or sodium hydroxide solution, in order to avoid serious irritation of the skin caused by impurities such as diethanolamine and nitrosamine remaining in the synthesis process of triethanolamine.
- the present invention selects potassium hydroxide or sodium hydroxide at a concentration of 5%.
- One of the solutions acts as a neutralizing agent, causing the acidic carbomer to form a salt, and the crimped molecules are opened and thickened to adjust the stability and viscosity of the formulation.
- the preparation method of the multifunctional aloe vera gel comprises the following steps:
- E is added to a 5% concentration of lye, and stirred to cool below 40 °C;
- Example 1 Weigh various ingredients according to the product of 10 kg of multifunctional aloe vera gel:
- Embodiment 2 is a diagrammatic representation of Embodiment 1:
- step B Add the product of step B and the extract of Portulaca oleracea, vacuum, stir at 30 rpm, continue cooling until the temperature drops below 45 ° C; then 1,3-butanediol, menthol, preservative, The essence is mixed uniformly and dissolved, and then put into the emulsification pot, stirred for 5 minutes, until completely dissolved and mixed uniformly; then, the alkali solution with a concentration of 5% is added, and the mixture is stirred and cooled to below 40 ° C;
- Embodiment 3 is a diagrammatic representation of Embodiment 3
- the three embodiments of the present invention are only specific examples of three arbitrary data within the scope of the present invention, and the resulting product has stable properties and good compatibility with the gel group. Weaving fine and uniform, no foreign matter, in accordance with the specified aroma, even under high temperature and low temperature conditions, there will be no delamination; in addition, the products of the invention have been tested for their pH, bacterial content and heavy metal content. It meets the quality requirements of skin care products; any other similar formulation that replaces each component with an equivalent substitute of the same nature is within the scope of the present invention.
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Abstract
一种多功能芦荟胶及其制备方法，所述多功能芦荟胶含有芦荟冻干粉、马齿苋提取物、高分子透明质酸钠、寡聚透明质酸钠、尿囊素、D-泛醇、薄荷脑、甜菜碱、β-葡聚糖等有效活性成分，以及甲基异噻唑啉酮和碘代丙炔基甲酸丁酯作为防腐剂，还含有卡波姆以及浓度为5%的氢氧化钾或氢氧化钠溶液中的一种作为碱液。其制备方法包括以下步骤：Α按重量百分比称取各组分备用；B将芦荟冻干粉用适量的水溶解，待用；C将高分子透明质酸钠、寡聚透明质酸钠、去离子水、尿囊素、D-泛醇、甜菜碱、β-葡聚糖、卡波姆分别投入乳化锅中，抽真空，以30-50转/分的速度混合搅拌，并加热至70°C，控制加热，继续搅拌至完全溶解后，冷却至50°C，加入B步骤所述产品及马齿苋提取物，抽真空，以30转/分搅拌，继续冷却至45°C以下；D将1，3-丁二醇、薄荷脑、防腐剂、香精混合均匀并溶解后加入乳化锅，搅拌5分钟，直至完全溶解并混合均匀；E加入浓度为5%的碱液，搅拌冷却至40°C以下；F出料。
Description
多功能芦荟胶及其制备方法 技术领域
本发明涉及一种芦荟胶， 特别是一种多功能芦荟胶及其制备方法。 背景技术
随着芦荟的美容功效逐渐受到人们的认可， 对其有效成分和功效的 研究与开发也逐步深入。 目前， 市面上的芦荟护肤品种类琳琅满目， 而 保湿作为护肤化妆品的一种基础功能， 选择具有优越的保湿能力且效果 持久的保湿剂， 对其维持皮肤良好肤质至关重要。 通常， 为增加护肤品 的保湿功效， 会在产品配方中添加保湿剂， 如甘油、 丙二醇、 山梨醇、
1，3-丁二醇等多元醇， 另具有独特保水润滑功能的天然保湿因子——透 明质酸钠通常也被添加到高档的化妆品中。 但是， 常用的透明质酸为高 分子透明质酸， 其分子量为几十万到上百万以上。 只添加普通常用的透 明质酸， 较难达到令消费者满意的多重保湿效果。
发明内容
为了克服现有技术的不足， 本发明提供一种性质温和、 使用安全、 具有优越的护肤美容作用的多功能芦荟胶及其制备方法。
本发明解决其技术问题所采用的技术方案是： 多功能芦荟胶， 按重 量百分比， 包括以下各组分：
芦荟冻干粉 0.10~1.50%、 马齿苋提取物 0.00%〜10.00%、 高分子透 明质酸钠 0.00%~1.00%、 寡聚透明质酸钠 0.00%〜1.00%、 尿囊素 0.00%~0.40%、 D-泛醇 0.00%〜5.00%、 甜菜碱 0.00%〜5.00%、 β-葡聚糖 0.10%〜3.00% 、 1,3- 丁 二 醇 1.00%〜15.00% 、 薄 荷 脑 0.00%~1.00%、 卡波姆 0.10%〜2.00%、 香精 0.00%-0.30%、 防腐剂 0.00%〜0.30%、 碱液 0.10%~10.00%、 去离子水 10.00%~90.00%。
多功能芦荟胶， 所述寡聚透明质酸钠是由酶切法制得的分子量为 3000-10000的低分子量的透明质酸钠。
多功能芦荟胶， 所述甜菜碱为化妆品级或药用级的甜菜碱。
多功能芦荟胶， 所述防腐剂是甲基异噻唑啉酮及碘代丙炔基氨甲酸 丁酯中的一种或两种混合。
多功能芦荟胶， 所述碱液是氢氧化钾或氢氧化钠溶液中的一种。 多功能芦荟胶， 所述碱液是浓度为 5%的氢氧化钾或氢氧化钠溶液 中的一种。
多功能芦荟胶的制备方法， 包括以下步骤：
Α按重量百分比称取各组分备用；
B将芦荟冻干粉用遣量的水溶解， 待用；
C高分子透明质酸钠、 寡聚透明质酸钠、 去离子水、 尿囊素、 D-泛 醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入乳化锅中， 抽真空， 以 3 0转 /分一 5 0转 /分,混合搅拌， 同时加热至 70°C温度后， 控制加热， 继 续搅拌直至完全溶解后， 冷却至温度 50Ό， 加入 Β步骤所述产品及马 齿苋提取物， 抽真空， 30转 I分搅拌， 继续冷却到温度下降到 45Ό以 下；
D将 1,3-丁二醇、 薄荷脑、 防腐剂、 香精混合均匀并溶解后投入乳 化锅， 搅拌 5分钟， 直至完全溶解并混合均匀；
Ε加入浓度为 5%的碱液， 搅拌冷却至 40°C以下；
F出料。 本实用新型的有益效果是： 本发明所述的多功能芦荟胶由于含有芦 荟冻干粉、 植物提取物、 透明质酸钠、 尿囊素、 D-泛醇、 薄荷脑、 甜菜 碱、 3 -葡聚糖等有效活性成分， 是一种性质温和、 使用安全、 具有优 越的保湿性能、 既能单独使用发挥芦荟自身的护肤效果、 又能与其它多 种护肤产品搭配使用发挥芦荟的多种护肤美容效果的多功能芦荟胶， 其 中， 芦荟具有防晒、 保湿、 镇痛、 抗菌消炎、 预防粉刺、 愈合浅表性创 口等作用； 马齿苋提取物具有抗过敏、 抗刺激、 消炎祛痘等作用； 复配 透明质酸钠是高分子透明质酸钠和寡聚透明质酸钠的混合物， 高分子透 明质酸钠具有良好的成膜性， 能锁住肌肤表层水分、 紧致皮肤， 而寡聚 透明质酸钠具有快速渗透、 深层保湿， 减少肌肤皱紋等作用； 尿囊素具
有润肤、 抗皱、 软化角质蛋白、 刺激组织生长、 促进伤口愈合等作用；
D -泛醇具有消炎、 保湿、 促进伤口愈合等作用； 薄荷脑具有止痒、 抗过 敏、 消肿止痛、 消炎抗菌等作用； 甜菜碱能改善肌肤的水分保持力， 激 发细胞活力，具有保持肌肤滋润、光滑、防止干燥和发暗的效果；而 β - 葡聚糖具有保湿、 抗衰老、 抗敏消炎、 对抗紫外线伤害、 促进疤痕的愈 合和再生等作用， 多种组分同时使用， 既能充分发挥每个组分的独特效 果， 又能保证整体产品的最佳效果。 具体实施方式
多功能芦荟胶， 按重量百分比， 包括以下各组分：
芦荟冻干粉 0.10〜1.50%、 马齿苋提取物 0.00°/。〜10.00%、 高分子透 明质酸钠 0.00%~1.00%、 寡聚透明质酸钠 0.00%〜1.00%、 尿囊素 0.00%〜0.40%、 D-泛醇 0.00%〜5.00%、 甜菜碱 0.00%〜5.00%、 β-葡聚糖 0.10%~3.00% 、 1,3- 丁 二 醇 1.00%〜15.00% 、 薄 荷 脑 0.00%~1.00%、 卡波姆 0.10%~2.00%、 香精 0.00%-0.30%、 防腐剂 0.00%〜0.30%、 碱液 0.10%〜10.00%、 去离子水 10.00%〜90.00%。 其中芦 荟冻干粉选用库拉索芦荟冻干粉作为主要功效性原料， 而该芦荟中所含 的芦荟甙、 氨基酸、 粘多糖等有效成分使其具有优越的护肤美容效果； 在芦荟的护肤基础上， 通过马齿苋提取物、 D-泛醇及 β-葡聚糖等多种有 效成分的复配加入， 使本发明多功能芦荟胶的杀菌消炎、 抗过敏、 抗衰 老、 促进破损皮肤愈合等功效得到了强化， 既能增加受损皮肤对外来细
菌的抵抗力， 又能促进表皮细胞增殖， 有助于受损部位的皮肤再生。 而 在保湿剂的选择上， 本发明选用了两种不同分子量的透明质酸钠——高 分子透明质酸钠及寡聚透明质酸钠作为保湿剂， 高分子量的透明质酸钠 分子能在皮肤表面形成透气的水化膜， 使角质层水合软化， 增加角质层 对活性物质的吸收利用； 而寡聚透明质酸钠能直接地渗入真皮层， 扩张 毛细血管、 增加血液微循环、 加强营养物质的供给， 通过两者的共同协 作， 达到更为全面、立体的保湿效果。而且本发明中加入的 1 ,3-丁二醇、 尿囊素及甜菜碱， 可从大气和皮肤深层吸收水分使皮肤保持润湿， 并改 善肌肤的水分保持力， 进一步提升了其吸水保水效果， 其中 1 ,3-丁二醇 还有良好的抑菌作用。 另外， 本发明选用卡波姆作为凝胶剂， 具有水溶 性基质的特点， 释药迅速、 无油腻性、 对皮肤和黏膜无刺激性， 使用时 能在皮肤表层形成保护膜， 隔绝外来污染物对皮肤的侵害。 此外， 为避 免三乙醇胺在合成过程残留的二乙醇胺、 亚硝胺等杂质对皮肤的严重刺 激性， 本发明选用了浓度为 5%的氢氧化钾或氢氧化钠溶液其中一种作 为中和剂， 使酸性的卡波姆成盐， 卷曲的分子张开而增稠， 从而调节制 剂的稳定性和黏度。 在防腐剂的选择上， 本发明将甲基异噻唑啉酮结合 碘代丙炔基氨甲酸丁酯一起使用， 能有效地防止化妆品在有效期内的腐 败变质及二次污染， 以保证产品的安全性和稳定性。 实验证明， 本发明 所述的多功能芦荟胶性质稳定、 兼容性良好， 凝胶组织细腻均匀、 无异 物、 符合规定香气， 即使在高温和低温的条件下也不会出现分层现象。
另外， 其 pH值、 细菌含量以及重金属含量等各项指标均符合护肤品的 质量要求。
多功能芦荟胶， 所述寡聚透明质酸钠是由酶切法制得的分子量为 3000-10000的低分子透明质酸钠；普通的护肤美容产品中基本上都只采 用了高分子量透明质酸纳， 而本发明选用了两种不同分子量的透明质酸 钠——高分子透明质酸钠及寡聚透明质酸钠作为保湿剂， 高分子量的透 明质酸钠分子能在皮肤表面形成透气的水化膜， 使角质层水合软化， 增 加角质层对活性物质的吸收利用； 而寡聚透明质酸钠能直接地渗入真皮 层， 扩张毛细血管、 增加血液微循环、 加强营养物质的供给， 通过两者 的共同协作， 达到更为全面、 立体的保湿效果。
多功能芦荟胶， 所述甜菜碱属于化妆品级或药用级的甜菜碱， 甜菜 碱能改善肌肤的水分保持力，激发细胞活力， 具有保持肌肤滋润、光滑、 防止干燥和发暗的效果；
多功能芦荟胶， 所述防腐剂是甲基异噻唑啉酮及碘代丙炔基氨甲酸 丁酯中的一种或两种混合； 本发明将甲基异噻唑啉酮结合碘代丙炔基氨 甲酸丁酯一起使用， 能有效地防止化妆品在有效期内的腐败变质及二次 污染， 以保证产品的安全性和稳定性；
多功能芦荟胶， 所述碱液是浓度为 5%的氢氧化钾或氢氧化钠溶液 中的一种， 为避免三乙醇胺在合成过程残留的二乙醇胺、 亚硝胺等杂质 对皮肤的严重刺激性， 本发明选用了浓度为 5%的氢氧化钾或氢氧化钠
溶液其中一种作为中和剂， 使酸性的卡波姆成盐， 卷曲的分子张开而增 稠， 从而调节制剂的稳定性和黏度。
多功能芦荟胶的制备方法， 包括以下步骤：
A按重量百分比称取各组分备用；
B将芦荟冻干粉用适量的水溶解， 待用；
C高分子透明质酸钠、 寡聚透明质酸钠、 去离子水、 尿囊素、 D-泛 醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入乳化锅中， 抽真空， 以 3 0转 /分一 5 0转 /分,混合搅拌， 同时加热至 70Ό温度后， 控制加热， 继 续搅拌直至完全溶解后， 冷却至温度 50°C， 加入 B步骤所述产品及马 齿苋提取物， 抽真空， 以 30转 /分搅拌， 继续冷却到温度下降到 45°C 以下；
D将 1,3-丁二醇、 薄荷脑、 防腐剂、 香精混合均匀并溶解后投入乳 化锅， 搅拌 5分钟， 直至完全溶解并混合均匀；
E加入浓度为 5%的碱液， 搅拌冷却至 40 °C以下；
F出料。
实施例一- 按 10公斤多功能芦荟胶成品称取各种成分：
芦荟冻干粉 10克、马齿苋提取物 100克、高分子透明质酸钠 1 0克、 寡聚透明质酸钠 5克、 尿囊素 15克、 D-泛醇 5 0克、 甜菜碱 100克、 β-
葡聚糖 1 0克、 1，3-丁二醇 500克、卡波姆 6 0克、 甲基异噻唑啉酮 1克、 碘代丙炔基氨甲酸丁酯 5克、 5 %氢氧化钾溶液 500克、 去离子水 8624 克备用； 首先将高分子透明质酸钠、 寡聚透明质酸钠、 去离子水、 尿囊 素、 D-泛醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入乳化锅中， 抽真空， 以 3 0转 /分一 5 0转 /分,混合搅拌， 同时加热至 70°C温度后， 控制 加热， 继续搅拌直至完全溶解后， 冷却至温度 50°C， 加入 B步骤所述 产品及马齿苋提取物， 抽真空， 以 30转 /分搅拌， 继续冷却到温度下 降到 45°C以下； 再将 1,3-丁二醇、 薄荷脑、 防腐剂、 香精混合均匀并溶 解后投入乳化锅， 搅拌 5分钟， 直至完全溶解并混合均匀； 然后加入浓 度为 5%的碱液， 搅拌冷却至 40°C以下； 出料。
实施例二：
按 10公斤多功能芦荟胶成品称取各种成分：
芦荟冻干粉 40克、 马齿苋提取物 200克、 高分子透明质酸钠 5克、 寡聚透明质酸钠 20克、尿囊素 10克、 D-泛醇 5 0克、甜菜碱 100克、 β- 葡聚糖 1 0克、 1 ,3-丁二醇 500克、 薄荷脑 1克、 卡波姆 120克、 甲基异 噻唑啉酮 1 克、 碘代丙炔基氨甲酸丁酯 5克、 5 %氢氧化钾溶液 1000 克、 去离子水 7763 克备用； 首先将高分子透明质酸钠、 寡聚透明质酸 钠、 去离子水、 尿囊素、 D-泛醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入 乳化锅中， 抽真空， 以 3 Q转 /分一 5 Q转 /分,混合搅拌， 同时加热至 70°C温度后， 控制加热， 继续搅拌直至完全溶解后， 冷却至温度 50°C ,
加入 B步骤所述产品及马齿苋提取物， 抽真空， 以 30转 /分搅拌， 继 续冷却到温度下降到 45°C以下； 再将 1,3-丁二醇、 薄荷脑、 防腐剂、 香 精混合均匀并溶解后投入乳化锅， 搅拌 5分钟， 直至完全溶解并混合均 匀； 然后加入浓度为 5%的碱液， 搅拌冷却至 40°C以下； 出料。
实施例三：
按 10公斤多功能芦荟胶成品称取各种成分：
芦荟冻干粉 5 0克、马齿苋提取物 100克、寡聚透明质酸钠 50克、 尿囊素 2 0克、 D-泛醇 300克甜菜碱、 300克、 β-葡聚糖 1 0克、 1,3-丁 二醇 300克、 卡波姆 130克、 甲基异噻唑啉酮 1克、 碘代丙炔基氨甲酸 丁酯 5克、 香精 5克、 5 %氢氧化钾溶液 1100克、 去离子水 7635克备 用； 首先将高分子透明质酸钠、 寡聚透明质酸钠、 去离子水、 尿囊素、 D-泛醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入乳化锅中， 抽真空， 以 3 0转 /分一 5 0转 /分，混合搅拌， 同时加热至 70°C温度后， 控制加热， 继续搅拌直至完全溶解后， 冷却至温度 50°C， 加入 B步骤所述产品及 马齿苋提取物，抽真空， 以 30转 /分搅拌，继续冷却到温度下降到 45°C 以下； 再将 1,3-丁二醇、 薄荷脑、 防腐剂、 香精混合均匀并溶解后投入 乳化锅， 搅拌 5分钟， 直至完全溶解并混合均匀； 然后加入浓度为 5% 的碱液， 搅拌冷却至 40°C以下； 出料。
总之， 本发明所述的三个实施例只是本发明保护范围内的三个任 意数据的具体实施例， 最后得到的产品性质稳定、 兼容性良好， 凝胶组
织细腻均匀、 无异物、 符合规定香气， 即使在高温和低温的条件下也不 会出现分层现象； 另外， 经测试本发明所述产品其 PH值、 细菌含量以 及重金属含量等各项指标均符合护肤品的质量要求； 任何其它以性质相 同的等同替代物代替各组分的类似配方都在本发明的保护范围之内。
Claims
1、 多功能芦荟胶， 按重量百分比， 包括以下各组分：
芦荟冻干粉 0.10〜1.50%、 马齿苋提取物 0.00%〜10.00%、 高分子透 明质酸钠 0.00%〜1.00%、 寡聚透明质酸钠 0.00%〜1.00%、 尿囊素 0.00%~0.40%, D-泛醇 0.00%〜5.00%、 甜菜碱 0.00%〜5.00%、 β-葡聚糖 0.10%~3.00% 、 1,3- 丁 二 醇 1.00%〜15.00% 、 薄 荷 脑 0.00%~1.00%、 卡波姆 0.10%〜2.00%、 香精 0.00°/ο-0.30%、 防腐剂 0.00%〜0.30%、 碱液 0.10%〜10.00%、 去离子水 10.00%~90.00%。
2、 根据权利要求 1 所述的多功能芦荟胶， 其特征在于所述寡聚透 明质酸钠是由酶切法制得的分子量为 3000〜10000的低分子量的透明质 酸钠。
3、 根据权利要求 1 所述的多功能芦荟胶， 其特征在于所述甜菜碱 为化妆品级或药用级的甜菜碱。
4、 根据权利要求 1 所述的多功能芦荟胶， 其特征在于所述防腐剂 是甲基异噻唑啉酮及碘代丙炔基氨甲酸丁酯中的一种或两种混合。
5、 根据权利要求 1 所述的多功能芦荟胶， 其特征在于所述碱液是 氢氧化钾或氢氧化钠溶液中的一种。
6、 根据权利要求 1 所述的多功能芦荟胶， 其特征在于所述碱液是 浓度为 5%的氢氧化钾或氢氧化钠溶液中的一种。
7、 多功能芦荟胶的制备方法， 包括以下步骤：
A按重量百分比称取各组分备用；
B将芦荟冻干粉用适量的水溶解， 待用；
C高分子透明质酸钠、 寡聚透明质酸钠、 去离子水、 尿囊素、 D-泛 醇、 甜菜碱、 β-葡聚糖、 卡波姆分别投入乳化锅中， 抽真空， 以 3 0转 /分一 5 0转 /分,混合搅拌， 同时加热至 70°C温度后， 控制加热， 继 续搅拌直至完全溶解后， 冷却至温度 50°C， 加入 B步骤所述产品及马 齿苋提取物， 抽真空， 以 30转 /分搅拌， 继续冷却到温度下降到 45°C 以下；
D将 1，3-丁二醇、 薄荷脑、 防腐剂、 香精混合均匀并溶解后投入乳 化锅， 搅拌 5分钟， 直至完全溶解并混合均匀；
E加入浓度为 5%的碱液， 搅拌冷却至 40°C以下；
F出料。
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