Classifications

• • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
  • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
  • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
  • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
  • F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
  • F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
  • F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
  • F16K11/076—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with sealing faces shaped as surfaces of solids of revolution
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
  • B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
• • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
  • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
  • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
  • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
  • F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
  • F16K11/08—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only taps or cocks
  • F16K11/085—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only taps or cocks with cylindrical plug
• • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
  • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
  • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
  • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
  • F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
  • F16K11/08—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only taps or cocks
  • F16K11/085—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only taps or cocks with cylindrical plug
  • F16K11/0856—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only taps or cocks with cylindrical plug having all the connecting conduits situated in more than one plane perpendicular to the axis of the plug
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
  • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T137/00—Fluid handling
  • Y10T137/8593—Systems
  • Y10T137/86493—Multi-way valve unit
  • Y10T137/86574—Supply and exhaust
  • Y10T137/8667—Reciprocating valve
  • Y10T137/86694—Piston valve
  • Y10T137/8671—With annular passage [e.g., spool]
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T137/00—Fluid handling
  • Y10T137/8593—Systems
  • Y10T137/87249—Multiple inlet with multiple outlet

Definitions

• the invention relates to a fluidic distributor adapted for the in-situ reconstitution of a solution by mixing two components from a first reservoir and a second reservoir, the fluidic distributor comprising a body defining an axial chamber and comprising first and second radial input / output ports for connection to the first tank and a circulation pump, and a radial administration port adapted for the output of the solution, the first and second input / output ports and the administration port communicating with the chamber, a rotatable crankpin housed in the chamber and traversed by connecting channels, the crank pin having third and fourth axial input / output ports for connection to the second reservoir and communicating with the channels connection channels being arranged to fluidically and selectively connect the first, second, third and fourth ports of trea / output and the administration port according to the angular position of the crankpin relative to the body so, in a first angular position, connect the first input / output port to the third input / output port and close the second port input / output port and the fourth input / output port
• the invention also relates to a device for reconstituting in situ and administering a solution obtained by mixing two components from a first and a second reservoir, the in situ reconstitution and administration device comprising a distributor.
• fluidic device comprising a body and a pin rotatable in said body, motorized drive means of the crank pin, a fluid circuit element arranged to connect the first and second input / output ports.
• a solution It is frequently necessary to mix constituents to reconstitute and homogenize, just before use, a solution. This is particularly the case for therapeutic solutions, in the medical or veterinary field or for other purposes for example in the cosmetics field. Mixtures or reconstitutions of solution, made just before using this same solution, are very useful when the solution is not stable after mixing and reconstitution. This is particularly the case for new therapeutic molecules of biological origin, which can only be preserved mainly in the form of solid powder to suspend or freeze-dried or to reconstitute just before administration.
• a first component is used in the form of solid powder, freeze-dried, dehydrated or concentrated, and a second component of the solvent type.
• reconstitution requires the follow-up of a specific protocol.
• the solution can be administered by any suitable means.
• administration is meant in particular any act allowing a constituent to be absorbed by a user, whether by an injection, an infusion, orally or cutaneously, or by any other suitable means.
• the reconstitution of a solution may require four to ten manual steps requiring the use of one or more syringes, vials, needles and the like to successively:
• the object of the invention is to overcome the disadvantages of existing fluidic distributors by proposing a fluidic dispenser of simple construction for obtaining the homogeneous reconstitution of a solution from the mixture of two components, easy to use by a user without training medical, the fluidic dispenser being optionally integrated with a device for mixing and administering the solution obtained, for example by injection.
• the subject of the invention is a fluidic distributor adapted for the in situ reconstitution of a solution by mixing two constituents coming from a first reservoir and a second reservoir
• the fluidic distributor comprising a body defining a axial chamber and having first and second radial input / output ports for connection to the first reservoir and a circulation pump, and a radial administration port adapted for the output of the solution, the first and second ports of input / output and the administration port communicating with the chamber, a rotatable crank pin housed in the chamber and traversed by connecting channels, the crank pin having third and fourth axial input / output ports to be connected to the second tank and communicating with the connecting channels, the connecting channels being arranged to fluidically and selectively connect the first, second, third and fourth rth input / output ports and the administration port according to the angular position of the crank pin with respect to the body so as to, in a first angular position, connect the first input / output port to the third input / output port and closing the second input /
• first, second, third are used in a nonlimiting manner to differentiate the similar elements.
• the idea underlying the invention is to provide a particular configuration of the connecting channels which provides a fluidic dispenser type 5/3, namely five ports and three positions, simple design and use.
• the connecting channels comprise the following three connecting channels:
• first inverted T-channel whose central branch is provided with the third input / output port, a first radial branch of which is provided with a first radial mouth and a second radial branch of which is provided with a second radial mouth.
• first connecting channel being arranged so that:
• the first radial mouth is located opposite the first inlet / outlet port and the second radial mouth is closed by the chamber wall
• the second radial mouth is located opposite the first input / output port and the first radial mouth is closed by the wall of the chamber
• the first and second radial mouths are closed by the wall of the chamber, a second inverted L-shaped connecting channel whose large bar is provided with the fourth input / output port and whose small bar is provided with a radial mouth, the second connecting channel being arranged so that:
• the radial mouth is closed by the wall of the chamber
• the radial mouth is located opposite the second input / output port
• a third connecting channel radially crossing the crank pin and provided with a first radial mouth and a second radial mouth, the third connecting channel being arranged so that:
• the first and second radial mouths are closed by the wall of the chamber
• the first radial mouth is located opposite the first input / output port and the second radial mouth is located opposite the administration port.
• the axes of the first and second radial mouths of the first connecting channel, the first radial mouth of the third connecting channel and the first input / output port are included in a first radial plane, the axes of the radial mouth of the second connecting channel and the second input / output port are included in a second radial plane distinct from the first radial plane,
• the axis of the second radial mouth of the third connecting channel and the administration port are included in a third radial plane distinct from the first and second radial planes.
• the first input / output port, the second input / output port and the administration port are located in the same median plane of the body, the first and second connecting channels are located in the same first axial plane of the crankpin ,
• the third connecting channel is located in a second axial plane of the crank pin angularly offset by 90 ° with respect to the first axial plane
• the connecting channels comprise the following two connecting channels:
• a first inverted L-shaped link channel having a plurality of small bars, the large bar of which is provided with the fourth input / output port, a first small bar of which has a first radial mouth, of which a second small bar is provided with a second radial mouth, of which a small third bar is provided with a third radial mouth, the first connecting channel being arranged so that:
• the first, second and third radial mouths are closed by the wall of the chamber
• the second radial mouth is located opposite the first inlet / outlet port and the first and third radial mouths are closed by the wall of the chamber
• the third radial mouth is located opposite the first inlet / outlet port, the first radial mouth is located opposite the administration port, the second radial mouth is closed by the chamber wall;
• a second inverted T-channel comprising a plurality of radial branches, whose central branch is provided with the third input / output port, a first radial branch of which is provided with a first radial mouth, of which a second branch radial is provided with a second radial mouth, of which a third radial branch is provided with a third radial mouth, the second connecting channel being arranged so that:
• the first radial mouth is located opposite the second inlet / outlet port and the second and third radial mouths are closed by the wall of the chamber,
• the second radial mouth is located opposite the second inlet / outlet port and the first and third radial mouths are closed by the wall of the chamber
• the third radial mouth is located opposite the second input / output port and the second and third radial mouths are closed by the wall of the chamber.
• the fluidic dispenser may comprise all of the following features:
• the axis of the first radial mouth of the first connecting channel and the administration port are included in a third radial plane distinct from the first and second radial planes.
• the fluidic dispenser may comprise the following features:
• the first, second input / output ports and the administration port are substantially located in the same median plane of the body, the first connecting channel is located in a first axial plane of the crank pin so that the passage between the first and second second angular positions is obtained by rotating a half turn of the crankpin in the body,
• the fluidic dispenser may comprise all of the following features:
• the axes of the first and third radial mouths of the first connecting channel and the first input / output port are included in a first radial plane
• the axis of the second radial mouth of the first connecting channel and the administration port are included in a third radial plane distinct from the first and second radial planes.
• the fluidic dispenser according to the invention comprises an annular seal provided between the crankpin and the body, the annular seal having a solid portion through which openings intended to be opposite the first radial mouth, second radial mouth, third mouthpiece radial radial of the first connecting channel, the first radial mouth, the second radial mouth, the third radial mouth of the second connecting channel and the first radial mouth and a second radial mouth of the third connecting channel, the solid portion being arranged to seal selective between the link channels.
• the invention extends to a device for reconstituting in situ and administering a solution obtained by mixing two components from a first and a second reservoir
• the device for reconstitution in situ and administration comprising a fluidic distributor comprising a body and a crank rotatable in the body, motorized drive means of the crankpin, a fluidic circuit element arranged to connect the first and second input / output ports, characterized in that comprises a fluidic distributor according to one any of the preceding claims, motor drive means of the crankpin, a fluid circuit element arranged to connect the first and second input / output ports and the first reservoir, a circulation pump connected to the fluid circuit element.
• Figure 1 is an exploded perspective view of the fluid dispenser according to a first embodiment of the invention
• Figures 2 and 3 are respectively sectional and front views of the fluidic distributor of Figure 1 in a first so-called transfer position;
• Figures 4 and 5 are views similar to Figures 2 and 3 illustrating a second so-called reconstituting position of the fluidic distributor of Figure 1;
• Figures 6 and 7 are views similar to Figures 2 and 3 illustrating a third position said administration of the fluid dispenser of Figure 1 wherein the administration is carried out from the first reservoir;
• Figures 8 and 9 are respectively sectional views of two embodiments of an in situ reconstitution device and administration provided with a fluidic dispenser according to the first embodiment of the invention
• Figure 10 is a schematic view of the fluidic distributor according to a second embodiment of the invention.
• FIGS. 11 to 13 are diagrammatic views of the fluidic distributor of FIG. 10 respectively in first, second and third positions similar to the previous ones, the administration being carried out at from the second tank;
• Figure 14 is a schematic view of the fluidic distributor of Figures 1-1 to 13 illustrated in a third position equivalent to that of Figure 13 and wherein, the administration being carried out from the second reservoir;
• Figure 15 is a schematic view similar to Figure 10 of the fluid dispenser according to a third embodiment of the invention.
• Figures 16 to 18 are schematic views of the fluidic distributor of Figure 15 similar to Figures 1 1 to 13.
• the fluidic dispenser and the device for reconstitution in situ and of administration according to the invention can be used for mixing a first liquid component with a second component of any type (concentrate, lyophilizate, powder, etc.).
• the reconstituted solution in situ can be administered by any suitable technique.
• the following description relates to a fluidic dispenser integrable to a device for mixing pharmaceutical constituents and administering the solution reconstituted by injection.
• the mixing and administering device 1a comprises a fluidic distributor 10a, an injection needle 11 (shown only in FIG. 8), motorized drive means 12, an element fluid circuit 13 and a circulation pump 14.
• the fluidic distributor 10a comprises a body 2, a crankpin 3a and an annular seal 4 provided between the body 2 and the crank pin 3a.
• the body 2 has a generally tubular shape and defines a cylindrical chamber 20 opening axially on either side of the body 2.
• the body 2 comprises first and second input / output ports 21, 22 radial and a port of administration 23 radially extending from the chamber 20 and disposed in the same median plane P1 of the body 2.
• the first and second input / output ports 21, 22 are diametrically opposed to the administration port 23.
• the axis of the first input / output port 21 is located in a first radial plane R1
• the axis of the second input / output port 22 is located in second radial plane R2 distinct from the first radial plane R1
• the axis of the port of administration 23 is located in a third radial plane R3 provided between the first and second radial planes R1, R2.
• the body 2 comprises an angular and axial abutment 24 whose function is specified below.
• the chamber 20 is provided with an inner shoulder 25 whose function is also specified below.
• the first and second input / output ports 21, 22 are intended to be connected to the circulation pump 14 and to a first reservoir 100 via the fluid circuit element 13.
• the Circulation pump 14 is provided between the first reservoir 100 and the first inlet / outlet port 21.
• the administration port 23 is adapted to allow the exit of the reconstituted solution and adapted for example to receive the fitting of an injection needle January 1 to administer the solution by injection.
• the pin 3a has a generally cylindrical shape and carries the annular seal 4 which has a generally tubular shape.
• the annular seal 4 is for example made of elastomer.
• the annular seal 4 is integral with the crank pin 3a on which it can be overmolded.
• the outer diameter of the annular seal 4 is substantially similar to that of the chamber 20.
• the crankpin 3a carrying the annular seal 4 can be housed in the chamber 20, the annular seal 4 ensuring the seal between the crank pin 3a and the body 2.
• Crankpin 3a is provided with third and fourth axial input / output ports 31, 32 provided at the same axial end of the crankpin 3a, each provided with a transfer needle 36, 37.
• each of these third and fourth ports of entry / outlet 31, 32 is provided with a transfer needle 36, 37 for perforating the stopper of a second reservoir 200, for example of the vial type.
• the transfer needles 36, 37 of the third and fourth input / output ports 31, 32 preferably have different lengths to promote mixing.
• the crankpin 3a is traversed by connecting channels 5a, 6a, 7a connected to the third and fourth input / output ports 31, 32.
• the connecting channels 5a, 6a, 7a comprise a first connecting channel 5a, a second channel link 6a and a third link channel 7a independent of each other.
• These connecting channels 5a, 6a, 7a have for example a substantially circular section.
• the first connecting channel 5a has an inverted T shape, the end of the central rod of which opens axially into a third axial input / output port 31 and whose branches traverse radially the crankpin 3a and open into a first radial mouth 51a and a second radial mouth 52a provided at the first radial plane R1 comprising the first input / output port 21.
• the second connecting channel 6a has an inverted L shape, the large bar of which opens axially into a fourth input / output port 32 and whose small bar opens radially into a first radial mouth. 61a whose axis is substantially coincidental in the second radial plane R2 comprising the second input / output port 22.
• the first and second connecting channels 5a, 6a are located in the same first axial plane A1 of the crank pin 3a.
• the central rod of the first connecting channel 5a and the second connecting channel 6a are arranged on either side of the axis M of the crank pin 3a.
• the third connecting channel 7a is inclined and laterally traverses the crankpin 3a opening into a first radial mouth 71a whose axis is substantially coincidental to the first radial plane R1 comprising the axis of the first port input / output 21 and a second radial end 72a whose axis is substantially coincident with the third radial plane R3 comprising the axis of the administration port 23, the first and second radial mouths 71a, 72a being diametrically opposed.
• the axis of the third connecting channel 7a is located in a second axial plane A2 of the crank pin 3a.
• the second axial plane A2 of the crank pin 3a is offset from the first axial plane A1 of the crank pin 3a by an angle of approximately 90 °.
• the third connecting channel 7a passes through the axis M of the crankpin 3a above the branches of the first connecting channel 5a.
• the dimensions of the connecting channels 5a, 6a, 7a are provided so that there is no interference between the first, second connecting channels 5a, 6a and the third connecting channel 7a.
• the third connecting channel may be provided so that its first end opens into a third radial plane coincident with the second radial plane comprising the second input / output port.
• the annular seal 4 has openings 40-44 transfer through and allowing the passage of fluid.
• the transfer orifices 40-44 thus comprise first and second diametrically opposed transfer orifices 40, 41 whose axes are provided in the first radial plane R1 and respectively facing the axes of the first and second radial mouths 51a, 52a of the first connecting channel 5a.
• the first and second transfer orifices 40, 41 are thus provided with their axes in the first axial plane A1.
• Transfer ports 40-44 also have a third transfer port 42 provided between the first and second transfer ports 40, 41 with an axis in the first radial plane R1, in the second axial plane A2 and opposite the first radial mouth 71a of the third connecting channel 7a.
• the connecting channels 40-44 comprise a fourth transfer port 43 with its axis provided in the second radial plane R2 and in the second axial plane A2, facing the second radial mouth 72a of the third connecting channel 7a.
• the connecting channels 40-44 comprise a fifth transfer orifice 44 whose axis is provided in the second radial plane R2 and in the first axial plane A1, facing the first radial mouth 61a of the second connecting channel. 6a.
• Each transfer port 40-44 is surrounded by an annular lip 45 reinforcing the seal between the annular seal 4 and the body 2.
• the annular seal 4 comprises on its periphery intermediate annular lips 46 for isolating between they the first, second and third radial planes R1, R2, R3.
• the annular seal 4 also comprises two annular end lips 47 provided respectively beyond the first radial plane R1 and the second radial plane R2 with respect to the third radial plane R3 and making it possible to isolate the first and second radial planes R1, R2 from the outside.
• the intermediate annular lips 46 may be connected to one another or to the annular end lips 47 by crosspieces 48 (visible in FIG. 7) preventing any annular fluidic circulation, reinforcing the tightness of the fluidic dispenser 1 Oa and making it possible to reduce the dead volume.
• the crankpin 3a is axially locked in the chamber 20 by the inner shoulder 25 in a first axial direction and the angular and axial abutment 24 in a second axial direction.
• the crankpin 3a has an external lateral rib 35 (visible in FIG. 1) designed to cooperate with the annular seal 4 to reinforce the rotational locking of the annular seal 4 with respect to the crankpin 3a.
• the crankpin 3a also has two shoulders 38 of diameter greater than the inner diameter of the annular seal 4 to lock axially relative to the crankpin 3a.
• the crankpin 3a is provided with a radial lug 33 intended to cooperate with the angular and axial abutment 24 of the body 2 to limit the rotation of the crankpin 3a relative to the body 2.
• crankpin 3a is coupled to motorized drive means 12 of the standard type adapted to angularly pivot the crankpin 3a and the annular seal 4 relative to the body 2 in predetermined angular positions.
• the mechanical coupling between the crankpin 3a and the motorized drive means 12 is of known type and designed to allow easy coupling and decoupling.
• the fluid circuit element 13 makes it possible to connect the first and second input / output ports 21, 22 together.
• the fluidic circuit element 13 may comprise a fluid conduit 131 whose ends are connected to the first and second input / output ports 21, 22, provided with first connection means 136 for its connection. the first tank 100 and secondary connection means 140 for its connection to a circulation pump 14 disposed between the first tank 100 and the first inlet / outlet port 21.
• the circulation pump is disposed between the first reservoir and the second input / output port.
• the body 2 may be laterally extended so that the first input / output port 21 is separated from the chamber 20 by a tube portion 133 provided with secondary connection means 140 for connection to a circulating pump 14 and first connection means 136 provided at the first input / output port 21 and allowing its connection to the first reservoir 100.
• the fluidic circuit element 13 comprises a fluid conduit 131 whose ends are connected to the first and second input / output ports 21, 22.
• the circulation pump 14 is of any type adapted to cause the circulation of the fluid contained between the first reservoir 100 and the second reservoir 200 and the first or second reservoir 100, 200 to the administration port 23.
• the mixing and administering device 1a is provided with a first reservoir 100 containing a first liquid component and a second reservoir 200 containing a second component, for example in the form of a powder.
• the first tank 100 is connected to the fluid distributor 10 between the first and second input-output ports 21, 22.
• the second tank 200 is connected to the fluidic distributor 10a between the third and fourth input-output ports 31, 32.
• the crankpin 3a is placed in a first angular position relative to the body 2, said transfer position, in which the first axial plane A1 of the crank pin 3a and the first median plane P1 of the body 2 are substantially confused.
• the first radial mouth 51a of the first connecting channel 5a is opposite the first input / output port 21, the second radial mouth 52a of the first connecting channel 5a being closed by the wall of the chamber 20.
• the circulation 14 is controlled to transfer the liquid from the first reservoir 100 to the second reservoir 200 containing the second component according to arrows S0.
• the liquid contained in the first tank 100 passes through the first inlet / outlet port 21, the first transfer port 40 of the annular seal 4, the first radial mouth 51a of the first connecting channel 5a, flows in the first connection channel 5a then passes through the axial mouth of the first connecting channel 5a and the third input / output port 31 before joining the second reservoir 200.
• the first radial mouth 61a of the second connecting channel 6a and the administration port 23 are closed by the wall of the room 20.
• the reconstituted solution is stirred so as to obtain a homogeneous mixture.
• This stirring is performed by circulating the mixture of the second reservoir 200 to the second reservoir 200 again.
• the crankpin 3a is rotated by 180 °, so as to place the crankpin 3_adans a second angular position relative to the body 2 This second position is called reconstitution.
• the second angular position is delimited by the radial lug 33 of the crank pin 3a in contact with the angular and axial abutment 24 of the body 2.
• the first axial plane A1 of the crankpin 3a and the median plane P1 of the body 2 are substantially merged but in an axially symmetrical configuration with respect to the previous one.
• the second radial mouth 52a of the first connecting channel 5a is opposite the first input / output port 21, the first radial mouth 51a of the first connecting channel 5a being closed by the wall of the the chamber 20.
• the first radial mouth 61a of the second connecting channel 6a is opposite the second input / output port 22.
• the administration port 23 is closed by the wall of the the chamber 20.
• the circulation pump 14 is controlled to transfer the liquid between the third and fourth input / output ports 31, 32 of the crank pin 3a.
• This fluid flow can be carried out according to a first direction of circulation, illustrated by the arrows S1, firstly passing through the fourth input / output port 32 and then the second connecting channel 6a, the first radial mouth 61a of the second connecting channel 6a, the fifth transfer port 44 of the annular seal 4, the second input / output port 22, the fluidic circulation element 13, the first input / output port 21, the second transfer port 41 of the annular seal 4, the second radial mouth 52a of the first connecting channel 5a, the first connecting channel 5a and the third input / output port 31.
• Fluid circulation can also be carried out according to a second direction of circulation, illustrated by the arrows S2, crossing firstly the third input / output port 31, the first connecting channel 5a, the second radial mouth 52a, the second transfer orifice 41 of the annular seal 4, the first input / output port 21, the fluid circulation element 13, the second input / output port 22, the fifth orifice 44 of the annular seal 4, the first radial mouth 61a of the second connection channel 6a, the second connecting channel 6a and the fourth input / output port 32.
• This fluid circulation makes it possible to mix the mixture of the first and second components and to obtain a homogeneous solution.
• crankpin 3a is rotated 90.degree., In the example illustrated clockwise by 90.degree. So as to place the crankpin 3_a in a third angular position with respect to the body 2.
• This third angular position referred to as administration is angularly intermediate between the first and second angular positions.
• the second axial plane A2 of the crankpin 3a and the median plane P1 of the body 2 are substantially merged.
• the first radial mouth 71a of the third connecting channel 7a is opposite the first input / output port 21, the second radial mouth 72a of the third connecting channel 7a is in position.
• view of the administration port 23, the second radial mouth 52a of the first connecting channel 5a and the radial mouth 61a of the second connecting channel 6a are closed by the wall of the chamber 20.
• the first port input / output 21 is connected to the administration port 23.
• the circulation pump 14 is controlled to transfer the liquid from the first reservoir 100 to the administration port 23 according to the arrows S3, via the first port inlet / outlet 21, so that the solution can be injected by the injection needle 1 1.
• the solution passes through the first input / output port 21, the third transfer port 42 of the annular seal 4, the third connecting channel 7a, the fourth transfer port 43 of the annular seal 4 and then the administration port 23 .
• crankpin and the seal form a single piece.
• the seal is fixed relative to the body.
• Figures 10 to 13 illustrate a fluidic distributor 10b according to a second embodiment of the invention comprising a body 2 similar to the previous and a crankpin 3b described below.
• crankpin 3b has third and fourth input / output ports 31, 32 similar to those of the previous crankpin 3a which it differs by its connecting channels 5b, 6b having a first connecting channel 5b and a second connecting channel 6b independent of each other.
• first connecting channel 5b is shown with a double line
• second connecting channel 6b is shown with a single line.
• the first connecting channel 5b has an inverted L shape with a plurality of small angularly and axially offset bars.
• the central rod of the first connecting channel 5b opens axially into a third input / output port 31.
• a first small bar of the first connecting channel 5b opens radially into a first radial mouth 51b
• a second bar of the first connecting channel 5b opens radially into a second radial mouth 52b
• a third bar of the first connecting channel 5b opens radially into a third radial mouth 53b.
• the first connecting channel 5b is located in the same first axial plane A1 of the crankpin 3b.
• the second radial mouth 52b and the third radial mouth 53b are distributed on either side of the central rod, their axes being included in a first radial plane R1 of the crank pin 3b comprising the axis of the first input / output port 21 .
• the axis of the first radial mouth 51b is included in a third radial plane R3 of the crank pin 3b provided between the first radial plane R1 and the third input / output port 31 and comprising the axis of the administration port 23
• the first connecting channel 5b is further provided with a first non-return valve 54 provided between the junction of the central rod with the first radial mouth 51b and the third input / output port 31 to prevent any fluid flow of one of the small bars to the third input / output port 31.
• the second connecting channel 6b has a T-shape having a plurality of radial branches and whose end of the central rod opens axially into a fourth axial input / output port 32.
• a first radial branch opens into a first radial mouth 61b
• a second radial branch opens into a second radial mouth 62b
• a third radial branch opens into a third radial mouth 63b.
• the axes of the first, second and third radial mouths 61b, 62b, 63b are included in a second radial plane R2 provided beyond the third radial plane R3 with respect to the first radial plane R1 and comprising the axis of the second port of
• the axes of the second and third radial mouths 62b, 63b are diametrically opposed, distributed on either side of the central rod and included in the first axial plane A1, and the axis of the first radial mouth 61b is included in a second axial plane A2.
• the second axial plane A2 is shifted by 90 ° relative to the first axial plane A1 so that the passage between the first and second positions, and the passage between the second and third positions, are respectively obtained by the rotation of a quarter turn of the crankpin in the body.
• the mixing and administering device 1b is substantially similar to the previous one. It differs in that the circulation pump 14 is provided between the first reservoir 100 and the second inlet / outlet port 22.
• the first reservoir 100 is coupled to a second nonreturn valve 101 to prevent any fluid flow to the reservoir.
• first tank 100 is coupled to a second nonreturn valve 101 to prevent any fluid flow to the reservoir.
• the crankpin 3b is placed in a first angular position relative to the body 2, said transfer position, in which the second axial plane A2 of the crank pin 3b and the first median plane P1 of the body 2 are substantially confused.
• the first radial mouth 61b of the second connecting channel 6b is opposite the second input / output port 22, the second and third radial mouths 62b, 63b of the second connecting channel 6b being closed by the wall of the chamber 20
• the circulation pump 14 is controlled to transfer the liquid from the first reservoir 100 to the second reservoir (not shown in this figure) containing the second component according to the arrows S0.
• the first, second and third radial mouths 51b, 52b, 53b of the first connecting channel 5b and the administration port 23 are closed off by the wall of the chamber 20.
• the crankpin 3b is rotated by 90 °, in the example illustrated in the antihair direction seen from above, so as to place the crankpin 3b in a second angular position called reconstitution relative to the body 2.
• the first axial plane A1 of the crankpin 3b and the median plane P1 of the body 2 are substantially merged, the second radial mouth 52b of the first connecting channel 5b is opposite the first input / output port 21, the first and third radial mouths 51b, 53b of the first channel of 5b connection being closed by the wall of the chamber 20.
• the second radial mouth 62b of the second connecting channel 6b is opposite the second input / output port 22, the first and third radial mouths 61b, 63b of the second connecting channel 6b and the administration port 23 are closed by the wall of the chamber 20.
• the circulation pump 14 is controlled to transfer the liquid between the fourth and third input / output ports 32, 31 of the crank pin 3b .
• This fluid circulation is carried out according to the first direction of circulation, illustrated by the arrows S1.
• the second non-return valve 101 prevents any fluid return to the first reservoir 100.
• crankpin 3b is rotated by 180 °, so as to place the crankpin 3_b in a third angular position known as delivery with respect to the body 2.
• This third angular position is substantially axially symmetrical at the first position angular.
• the first axial plane A1 of the crank pin 3b and the median plane P1 of the body 2 are substantially merged, the third radial mouth 53b of the first connecting channel 5b is opposite the first input / output port 21, the first radial mouth 51b of the first connecting channel 5b is opposite the administration port 23 and the second radial mouth 52b of the first connecting channel 5b is closed by the wall of the chamber 20.
• the third radial mouth 63b of the second connecting channel 6b is opposite the second input / output port 22, the first and second radial mouths 61b, 62b of the second connecting channel 6b are closed by the wall of the chamber 20.
• the circulation pump 14 is controlled to transfer the liquid from the second tank to the administration port 23 as illustrated by the arrows S3.
• the first check valve 54 prevents any fluid return to the second tank by the second channel 5b.
• the administration is thus carried out from the second reservoir.
• the solution of the second reservoir is transferred to the first reservoir. To do this, it rotates the crankpin 3b of the second position in the first angular position of Figure 12 by pivoting the crankpin 3b of 90 °, in the example shown in the clockwise view from above.
• the circulation pump 14 is controlled so as to transfer the solution contained in the second reservoir to the first reservoir 100 in the direction of circulation illustrated by the arrows S4 opposite the arrows S0 of FIG. 12.
• the device mixing and administration 1 b does not include a second non-return valve 101. Then to move from this position to the third position described above, turn the crankpin 3b 90 ° in the example shown in the clockwise view from above and proceed to the administration of the solution contained in the first tank 100 .
• Figures 15 to 18 illustrate a fluidic distributor 10c according to a third embodiment of the invention comprising a body 2 similar to the previous and a pin 3c described below.
• the crank pin 3c comprises third and fourth input / output ports 31, 32 similar to those of the previous crank pins 3a, 3b, of which it differs by its connecting channels 5c, 6c comprising a first connecting channel 5c and a second channel of FIG. link 6c independent between them.
• the first connecting channel 5c is shown with a double line
• the second connecting channel 6c is shown with a single line.
• the first connecting channel 5c has an inverted L shape with a plurality of small angularly and axially offset bars.
• the central rod of the first connecting channel 5c opens axially into a third input / output port 31.
• a first small bar of the first connecting channel 5c opens radially into a first radial mouth 51 ç
• a second bar of the first connecting channel 5c opens radially into a second radial mouth 52c
• a third bar of the first connecting channel 5c opens radially into a third radial mouth 53c.
• the first connecting channel 5c is located in the same first axial plane A1 of the crank pin 3c.
• the axes of the second and third radial mouths 52c, 53c are included in a first radial plane R1 of the crank pin 3c comprising the axis of the first input / output port 21.
• the axes of the second and third radial mouths 52c_, 53c are also angularly offset between them, in the example shown, they are shifted by 90 °.
• the axis of the first radial mouth 51 ç of the crank pin 3c is included in a third radial plane R3 of the crank pin 3c comprising the axis of the administration port 23 and located between the first radial plane R1 and the third input port / exit 31.
• the axes of the first and third radial mouths 51c, 53c are included in a first axial plane A1 of the crank pin 3c.
• the first connecting channel 5c is further provided with a first non-return valve 54 provided between the junction of the central rod with the first radial mouth 51c and the third input / output port 31 to prevent any fluid flow of the one of the small bars to the third input / output port 31.
• the second connecting channel 6c has a T-shaped shape comprising a plurality of radial branches and the end of the central rod opens axially into a fourth axial input / output port 32.
• a first radial branch opens into a first radial mouth 61c
• a second radial branch opens into a second radial mouth 62c
• a third radial branch opens into a third radial mouth 63c.
• the axes of the first, second and third radial mouths 61c, 62c, 63c. are included in a second radial plane R2 provided beyond the third radial plane R3 with respect to the first radial plane R1 and comprising the axis of the second input / output port 22.
• the axes of the first and third radial mouths 61 ç, 63ç_ are diametrically opposite, distributed on either side of the central rod and included in the first axial plane A1, and the axis of the second radial mouth 62c is included in a second axial plane A2.
• the second axial plane A2 is shifted by 90 ° relative to the first axial plane A1 so that the passage between the first and second positions, and the passage between the second and third positions, are respectively obtained by the rotation of a quarter turn of the crankpin in the body.
• the mixing and administering device 1 is substantially similar to the previous one. It differs in the configuration of the first and second connecting channels 5c, 6c.
• the crankpin 3c is placed in a first angular position relative to the body 2, said transfer position, in which the second axial plane A1 of the crankpin 3c and the first median plane P1 of the body 2 are substantially merged.
• the first radial mouth 61c of the second connecting channel 6c is opposite the second input / output port 22, the second and third radial mouths 62c, 63c of the second connecting channel 6c being closed by the wall of the chamber 20
• the circulation pump 14 is controlled to transfer the liquid from the first reservoir 100 to the second reservoir (not shown in this figure) containing the second component according to the arrows S0.
• the first, second and third radial mouths 51c, 52c, 53c of the first connecting channel 5c and the administration port 23 are closed off by the wall of the chamber 20.
• the solution is stirred. To do this, it rotates the crankpin 3c 90 °, in the example shown in the horaie seen from above, so as to place the crankpin 3c in a second angular position called reconstitution relative to the body 2.
• the second axial plane A2 of the crankpin 3c and the median plane P1 of the body 2 are substantially merged, the second radial mouth 52c of the first connecting channel 5c is opposite the first input / output port 21, the first and third radial mouths 51c, 53c of the first connecting channel 5c_ being closed off by the wall of the chamber 20.
• the second radial mouth 62c of the second connecting channel 6c_ is opposite the second input / output port 22, the first and second third radial mouths 61c, 63c of the second connecting channel 6c and the administration port 23 are closed by the wall of the chamber 20.
• the circulation pump 14 is controlled to transfer the liquid between the third and fourth input ports / output 31, 32 of the crankpin 3b. This fluid circulation is carried out according to the first direction of circulation, illustrated by the arrows S1.
• the second non-return valve 101 prevents any fluid return to the first reservoir 100.
• crankpin 3c of 90.degree. Is pivoted, in the example illustrated in the horological direction seen from above, so as to place the crankpin 3c in a third angular position known as delivery with respect to the body 2
• This third angular position is substantially axially symmetrical at the first angular position.
• the first axial plane A1 of the crank pin 3c and the median plane P1 of the body 2 are substantially merged, the third radial mouth 53c of the first connecting channel 5c_ is opposite the first input / output port 21, the first radial mouth 51c of the first connecting channel 5b is opposite the administration port 23 and the second radial mouth 52c of the first connecting channel 5c is closed off by the wall of the chamber 20.
• the third radial mouth 63c of the second connecting channel 6c is opposite the second input / output port 22, the first and second radial mouths 61c, 62c of the second connecting channel 6c_ are closed off by the wall of the chamber 20.
• the circulation pump 14 is ordered to transfer the liquid of the second reservoir to the administration port 23 as illustrated by the arrows S3.
• the first check valve 54 prevents any fluid return to the second tank by the second channel 5c. The administration is thus carried out from the second reservoir.
• the mixing and administering device 1 a; 1 b; 1 ç thus comprises a disposable portion and a reusable portion.
• the motorized drive means 12 can easily be decoupled from the crankpin 3 to be used with another fluid distributor 10a; 10b; 10c.
• the invention achieves the previously mentioned objectives. Indeed, the use of the fluidic dispenser and the mixing and administration device is simple. The external and internal fluidic paths of the fluidic distributor are simplified.

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• Infusion, Injection, And Reservoir Apparatuses (AREA)
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• 2012
  • 2012-07-27 FR FR1257291A patent/FR2993791B1/fr active Active
• 2013
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