WO2013185282A1 - 生化检测系统及其光源模块 - Google Patents
生化检测系统及其光源模块 Download PDFInfo
- Publication number
- WO2013185282A1 WO2013185282A1 PCT/CN2012/076727 CN2012076727W WO2013185282A1 WO 2013185282 A1 WO2013185282 A1 WO 2013185282A1 CN 2012076727 W CN2012076727 W CN 2012076727W WO 2013185282 A1 WO2013185282 A1 WO 2013185282A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light source
- light
- halogen
- filter
- beam splitter
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 45
- 150000002367 halogens Chemical class 0.000 claims abstract description 45
- 238000001228 spectrum Methods 0.000 claims abstract description 18
- 230000003287 optical effect Effects 0.000 claims description 34
- 238000001514 detection method Methods 0.000 claims description 32
- 239000006185 dispersion Substances 0.000 claims description 7
- 241000143243 Idaea flaveolaria Species 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 229910052724 xenon Inorganic materials 0.000 description 6
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 2
- 235000005811 Viola adunca Nutrition 0.000 description 1
- 240000009038 Viola odorata Species 0.000 description 1
- 235000013487 Viola odorata Nutrition 0.000 description 1
- 235000002254 Viola papilionacea Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0213—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using attenuators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2803—Investigating the spectrum using photoelectric array detector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/10—Beam splitting or combining systems
- G02B27/1006—Beam splitting or combining systems for splitting or combining different wavelengths
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/10—Beam splitting or combining systems
- G02B27/14—Beam splitting or combining systems operating by reflection only
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/10—Beam splitting or combining systems
- G02B27/14—Beam splitting or combining systems operating by reflection only
- G02B27/141—Beam splitting or combining systems operating by reflection only using dichroic mirrors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J2003/1282—Spectrum tailoring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3155—Measuring in two spectral ranges, e.g. UV and visible
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06166—Line selective sources
- G01N2201/0618—Halogene sources
Definitions
- the present invention relates to a biochemical detection system, and more particularly to an optical biochemical detection system. Background technique
- xenon lamps can provide a light source with a small intensity difference in the visible light range, which is beneficial to the subsequent analysis.
- the higher price of xenon lamps is not conducive to the popularization of optical biochemical detection systems.
- the current optical biochemical detection system also uses a low-cost halogen light source, it may need to analyze the light source of the visible light wavelength when performing the analysis, and it is necessary to perform multiple times to complete the analysis of the visible light spectrum, but not the visible light full spectrum at one time. Analysis. This is not allowed for some full spectrum analysis of visible light. The difference between the intensity of the halogen source in the visible range may exceed 20 times. After sensing the full spectrum of visible light, the subsequent analysis may be difficult or impossible to perform.
- a light source module for a biochemical detection system includes a light source that passes through the first light source path and the second light source path and is collected by the first beam splitter to detect a waiting Test the sample.
- the first light source path includes a plurality of mirrors and a first filter for attenuating the light source of the orange band in the halogen light source.
- the second light source path includes a second filter for attenuating the light source other than the ultraviolet light band in the halogen light source.
- the mirror is a mirror having a wavelength between 300 nm and 800 nm.
- the first filter is located between the halogen source on the first source path and the first beam splitter.
- the first filter is located on the second light source path. Between the mirror and the halogen source.
- the light source in the orange band is a light source having a wavelength of 550 nm or more in the halogen light source.
- the second filter is for attenuating the wavelength other than the halogen source
- the biochemical detection system further includes a second beam splitter for distributing the halogen light source to the first light source path and the second light source path.
- the first filter is located between the first beam splitter and the second beam splitter on the first optical path.
- a biochemical detection system which includes a light source module as described above and an optical spectrum analyzer.
- the spectrum analyzer is used to analyze the light that passes through the sample to be tested.
- a spectrum analyzer includes an entrance slit, a focus dispersion component, and a photodiode array.
- the entrance slit is for receiving light that passes through the sample to be detected.
- the focusing dispersive component is used to spatially disperse the light that travels through the entrance slit.
- a photodiode array is used to sense the light that has been developed by the focused dispersion component.
- a spectrometer in accordance with another embodiment of the present invention, includes an entrance slit, a parallel light mirror, a dispersive component, a concentrating mirror, and a photodiode array.
- the entrance slit is for receiving light that passes through the sample to be detected.
- Parallel light mirrors are used to reflect light that traverses the entrance slit.
- the dispersive component is used to expand the light reflected by the collimator.
- the photodiode array is used to sense the light that has spread through the dispersive component.
- a concentrating mirror is used to focus the light that has been unfolded through the dispersive component onto the photodiode array.
- the biochemical detection system of the present invention uses only a single halogen light source, and uses its optical module to improve the characteristics of the halogen light source, so that the halogen light source can better meet the requirement of full spectrum detection in the visible light range, thereby replacing High-cost xenon light sources and other specific wavelengths of LED light sources can reduce the cost of components of biochemical detection systems.
- FIG. 1A is a diagram showing a biochemical detection system in accordance with one embodiment of the present invention.
- FIG. 1B is a diagram showing a biochemical detection system according to another embodiment of the present invention.
- 2 and 3 are data diagrams respectively measured before and after the light source module of the biochemical detection system according to the present invention is processed by the optical module.
- FIG. 4 is a schematic diagram of an optical module in accordance with one embodiment of the present invention.
- FIG. 5 is a schematic diagram of an optical module in accordance with another embodiment of the present invention. detailed description
- the biochemical detection system 100 includes a halogen light source 102, an optical module 104, and a spectrum analyzer 108, whereby optical analysis is performed on the sample to be detected 106a loaded in the sample carrier disk 106.
- the function of the optical module 104 is to adjust the optical characteristics of the halogen source 102 to enable the halogen source 102 to more closely meet the needs of optical analysis.
- the spectrum analyzer 108 includes an incident slit 108b, a parallel light mirror 108c, a dispersive component 108d, a condensing mirror 108e, and a photodiode array 108a.
- the incident slit 108b is for receiving the light passing through the sample to be detected 106a and sampling.
- the parallel light mirror 108c is for reflecting light passing through the incident slit 108b so that the light is transmitted in parallel to the dispersing component 108d.
- the dispersive component 108d is configured to expand the light reflected by the parallel light mirror 108c to facilitate sensing by the photodiode array 108a.
- the concentrating mirror 108e is used to focus the light expanded by the dispersing component 108d onto the photodiode array 108a to facilitate sensing.
- a biochemical detection system in accordance with another embodiment of the present invention is illustrated.
- the main difference between the biochemical detection system 100' and the biochemical detection system 100 is that the parallel light mirror 108c and the dispersive component 108d are integrated into a single focus dispersion component 108f, and the unnecessary condenser lens 108e is omitted.
- the focus dispersion component 108f is used to spatially disperse the light that has passed through the entrance slit 108b and direct the developed light to the photodiode array 108a.
- the structure of the above spectrum analyzer is merely an example, and the spectrum analyzer to which the present invention is applied is not limited to the above examples.
- FIGs 2 and 3 there are respectively shown data plots of the halogen source of the biochemical detection system in accordance with the present invention before and after processing by the optical module (the vertical axis is the relative intensity value, so there is no absolute unit).
- Figure 2 is a graph of data measured before the halogen source is processed by the optical module
- Figure 3 is a graph of the data measured by the halogen source after processing by the optical module.
- the intensity of the light emitted by the halogen source in the visible range (wavelength between about 400 nm and 750 nm) will be more than 20 times (for example, 60000/2946>20).
- the biochemical detection system of the present invention incorporates an optical module (eg, an optical mode) Block 104), to process the halogen light source, the measured data map after processing is shown in FIG. It can be seen from Fig. 3 that the light intensity difference in the range of visible light (wavelength between about 400 nm and 750 nm) will be less than 5 times (for example, 60000/12000 ⁇ 5), which will make subsequent data analysis much easier.
- an optical module eg, an optical mode
- Block 104 the measured data map after processing is shown in FIG. It can be seen from Fig. 3 that the light intensity difference in the range of visible light (wavelength between about 400 nm and 750 nm) will be less than 5 times (for example, 60000/12000 ⁇ 5), which will make subsequent data analysis much easier.
- the optical module 104 increases the blue-violet light source required for biochemical detection, the light intensity near the wavelength of 400 nm is greatly increased.
- the optical module 104' includes a single halogen light source 102a.
- the light from the single halogen light source 102b passes through the first light source path 101a and the second light source path 101b, respectively, and is collected by the first beam splitter 104b to detect a sample to be detected (for example, Sample to be tested 106a) of Figure 1A.
- the first light source passage 101a includes a plurality of mirrors and a first filter 104e for attenuating a light source having a wavelength greater than 550 nm in the halogen light source 102a (i.e., a light source in an orange band).
- the second light source path 101b includes a second filter 104a for attenuating the light source other than the wavelength between 320 nm and 400 nm (i.e., the ultraviolet band) of the halogen light source 102a.
- the first filter 104e can be located between the halogen light source 102a on the first light source path 101a and the first beam splitter 104b, and the first filter 104a is located on the second light source path 101b.
- the mirrors (104c, 104d, 104O may be mirrors or other suitable mirrors having a wavelength between 300 nm and 800 nm. Further, the mirrors (104c, 104d, 104O) The number is unlimited and the number of mirrors can be changed by the needs of the optical module.
- the optical module 104" differs from the optical module 104' mainly in that the second beam splitter 104b' is added.
- the optical module 104" includes a single halogen light source 102b, and light from the single halogen light source 102b passes through the first light source path 101a and the first After the two light source paths 101b are collected by the first beam splitter 104b, a sample to be detected (for example, the sample to be detected 106a of FIG. 1A) is detected.
- the added second beam splitter 104b' is configured to distribute the halogen light source 102b to the first light source path 101a and the second light source path 101l.
- the first light source path 101a includes a first filter 104e and a plurality of mirrors, and the first filter 104e It is used to attenuate a light source having a wavelength greater than 550 nm in the halogen light source 102b (ie, a light source in an orange band).
- the second light source path 101b includes a second filter 104a for attenuating other light sources in the halogen light source 102b except for wavelengths between 320 nm and 400 nm (ie, the ultraviolet band).
- the first filter 104e may be located at any position between the first beam splitter 104b and the second beam splitter 104b' on the first light source path 101a, and the second filter The mirror 104a is located between the first beam splitter 104b and the second beam splitter 104b' on the second light source path 101b.
- the mirrors (104c, 104d) may be mirrors or other suitable mirrors having a wavelength between 300 nanometers and 800 nanometers.
- the number of mirrors (104c, 104d) is not limited and the number of mirrors can be varied as required by the optical module.
- the biochemical detection system of the present invention uses only a single halogen light source, and utilizes its optical module to improve the characteristics of the halogen light source, so that the halogen light source can better meet the requirements of full spectrum detection in the visible light range. This replaces the higher cost xenon source and other specific wavelengths of the LED source, allowing the component cost of the biochemical detection system to be further reduced.
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201290000421.9U CN203719767U (zh) | 2012-06-11 | 2012-06-11 | 生化检测系统及其光源模块 |
DE112012006501.8T DE112012006501B4 (de) | 2012-06-11 | 2012-06-11 | Biochemisches Analysesystem und Lichtmodul desselben |
PCT/CN2012/076727 WO2013185282A1 (zh) | 2012-06-11 | 2012-06-11 | 生化检测系统及其光源模块 |
US14/376,845 US20150049328A1 (en) | 2012-06-11 | 2012-06-11 | Biochemical analyzing system and light module thereof |
TW101143099A TWI470202B (zh) | 2012-06-11 | 2012-11-19 | 生化檢測系統 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2012/076727 WO2013185282A1 (zh) | 2012-06-11 | 2012-06-11 | 生化检测系统及其光源模块 |
Publications (1)
Publication Number | Publication Date |
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WO2013185282A1 true WO2013185282A1 (zh) | 2013-12-19 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/CN2012/076727 WO2013185282A1 (zh) | 2012-06-11 | 2012-06-11 | 生化检测系统及其光源模块 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150049328A1 (zh) |
CN (1) | CN203719767U (zh) |
DE (1) | DE112012006501B4 (zh) |
TW (1) | TWI470202B (zh) |
WO (1) | WO2013185282A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109406411B (zh) * | 2017-08-15 | 2022-02-15 | 台湾超微光学股份有限公司 | 光源装置 |
CN113008814A (zh) * | 2021-02-22 | 2021-06-22 | 山东省科学院海洋仪器仪表研究所 | 一种利用双激光器进行水汽浓度检测的装置及方法 |
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2012
- 2012-06-11 DE DE112012006501.8T patent/DE112012006501B4/de active Active
- 2012-06-11 US US14/376,845 patent/US20150049328A1/en not_active Abandoned
- 2012-06-11 CN CN201290000421.9U patent/CN203719767U/zh not_active Expired - Lifetime
- 2012-06-11 WO PCT/CN2012/076727 patent/WO2013185282A1/zh active Application Filing
- 2012-11-19 TW TW101143099A patent/TWI470202B/zh active
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CN1338623A (zh) * | 2001-10-12 | 2002-03-06 | 周向前 | 微型双光谱检测生化分析仪 |
WO2007111408A1 (en) * | 2006-03-29 | 2007-10-04 | Korea Electro Technology Research Institute | Light source for fluorescence diagnosis and photodynamic therapy |
CN101308156A (zh) * | 2007-05-16 | 2008-11-19 | 株式会社日立高新技术 | 分析装置 |
CN201368878Y (zh) * | 2009-01-23 | 2009-12-23 | 北京松上技术有限公司 | 用于全自动生化分析仪的改良型光谱仪 |
CN102175324A (zh) * | 2011-01-26 | 2011-09-07 | 中国科学院长春光学精密机械与物理研究所 | 基于面阵探测器的多通道低杂散光光谱仪 |
CN202177452U (zh) * | 2011-07-27 | 2012-03-28 | 杭州轻通博科自动化技术有限公司 | 采用卤钨灯滤光模拟的d65光源 |
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TWI470202B (zh) | 2015-01-21 |
US20150049328A1 (en) | 2015-02-19 |
CN203719767U (zh) | 2014-07-16 |
DE112012006501B4 (de) | 2016-04-28 |
DE112012006501T5 (de) | 2015-04-02 |
TW201350824A (zh) | 2013-12-16 |
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