WO2013149445A1 - 预装式混药器 - Google Patents

预装式混药器 Download PDF

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Publication number
WO2013149445A1
WO2013149445A1 PCT/CN2012/079609 CN2012079609W WO2013149445A1 WO 2013149445 A1 WO2013149445 A1 WO 2013149445A1 CN 2012079609 W CN2012079609 W CN 2012079609W WO 2013149445 A1 WO2013149445 A1 WO 2013149445A1
Authority
WO
WIPO (PCT)
Prior art keywords
guiding
sleeve
groove
preloaded
guide
Prior art date
Application number
PCT/CN2012/079609
Other languages
English (en)
French (fr)
Inventor
邱宇
李科
袁媛
李鸿宇
黄叶莉
Original Assignee
重庆莱美药业股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201210224552.1A external-priority patent/CN102716033B/zh
Priority claimed from CN201210224556.XA external-priority patent/CN102716035B/zh
Priority claimed from CN201210224566.3A external-priority patent/CN102716039B/zh
Priority claimed from CN 201210224563 external-priority patent/CN102716523B/zh
Priority claimed from CN2012102245555A external-priority patent/CN102716522B/zh
Priority claimed from CN 201210224553 external-priority patent/CN102716521B/zh
Priority claimed from CN201210224557.4A external-priority patent/CN102716036B/zh
Application filed by 重庆莱美药业股份有限公司 filed Critical 重庆莱美药业股份有限公司
Priority to US14/415,605 priority Critical patent/US9839581B2/en
Priority to CA2877515A priority patent/CA2877515C/en
Priority to EP12873551.1A priority patent/EP2845578B1/en
Publication of WO2013149445A1 publication Critical patent/WO2013149445A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the invention relates to a medical device, in particular to a drug mixture used in a mixed drug.
  • the mixed solution is then input to a patient such as a hospital clinical institution.
  • a drug dispenser is often used to connect a drug container to an infusion soft bag or an infusion soft bottle.
  • the dosing device of the prior art mainly comprises a adding cartridge and a dosing double needle, and the adding cartridge forms a cup-shaped structure, and the dosing double needle is stuck in the charging cartridge through the double needle supporting seat, in order to seal the mixed drug channel a diaphragm is arranged on the cross section of the inner wall of the bottom of the filling cartridge, and a sealing film is arranged at the top end of the filling cartridge, and a needle tip of the dosing double needle corresponds to the diaphragm, and the other needle tip of the dosing double needle and the sealing film above correspond.
  • the interface of the filling tube with the infusion soft bag or the infusion soft bottle is docked, the sealing film on the top of the filling tube is torn off, and the drug container is inserted into the filling tube, and the drug container is also pushed in.
  • the dosing double needle is moved down, the upper needle tip of the dosing double needle pierces the sealing plug on the drug container, the lower needle of the dosing double needle pierces the diaphragm and pierces the sealing plug on the interface of the infusion soft bag or the infusion soft bottle
  • Mixing infusion soft bags or infusion soft bottles can achieve mixed medicine.
  • the dosing device with the above structure mainly has the following disadvantages in the mixing process: when the drug container is inserted into the cartridge, the sealing film on the top of the cartridge must be torn off first, and the cartridge is added when the cartridge is inserted. Contact with the outside world, resulting in pollution. and All the closed type dosing devices appearing in the prior art can only achieve the sealing in the mixing process, and can not realize the "full process aseptic sealing" when the drug container and the dosing device are docked, mixed and infused. .
  • the present invention provides a method for transporting, storing, docking, mixing, and infusion in a fully sterilized state.
  • Pre-filled blender Pre-filled blender.
  • the invention also provides a method for sealing, mixing and infusion in a completely sterilized state.
  • Pusher used on pre-filled blenders.
  • the present invention adopts the following technical solutions:
  • the first pre-filled drug mixture provided by the invention comprises a rotary sleeve, a guiding sleeve I, a guiding sleeve II, a guiding component, a filling cylinder and a dosing double needle; the dosing double needle is arranged in the charging cylinder ,
  • One end of the guiding sleeve I extends into the guiding sleeve II, and the other end of the guiding sleeve I is connected with one end of the rotating sleeve;
  • the side wall of the guiding sleeve I is provided with a guiding through groove in the axial direction, and the guiding through slot The two ends extend a distance in the opposite direction on the circumference of the guiding sleeve I, and the bottom end of the guiding groove extends in the direction of the circumference of the guiding sleeve I and the rotation direction of the rotating sleeve when pushing the medicine container;
  • One end of the charging cartridge is an interface connecting end, and the other end is connected to one end of the guiding sleeve II; the inner wall of the guiding sleeve II is provided with a guiding spiral groove;
  • the guiding member is disposed in the guiding sleeve 1.
  • the outer side of the guiding member has a guiding block.
  • the guiding block passes through the guiding through groove and extends into the guiding spiral groove, so that the rotating sleeve and the guiding sleeve II are axially fixed and radial. Rotating fit.
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is corresponding to the dosing; the one end of the guiding cylinder is open, and the open end of the guiding cylinder and the dosing double
  • the inner cavity of the guiding cylinder is a drug container accommodating cavity.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve 1.
  • the outer wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on the other end of the guide sleeve II and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve II through the sealing ring.
  • two guiding spiral grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves are arranged symmetrically on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically arranged
  • the adding cartridge is integrally formed with the guiding sleeve II.
  • the inner wall of the charging cartridge is symmetrically disposed with at least two anti-slip buckles in the shape of a barb and used to prevent loosening of the drug container.
  • annular rubber pad is disposed on the inner wall of the charging cartridge and adjacent to the interface connecting end, and the needle tip corresponding to the connecting end of the dosing pin passes through the annular rubber pad.
  • the bottom end of the filling cartridge is provided with a snap-fit assembly for connecting the interface of the infusion container and the interface connection end.
  • the snap-fit component is a ring-shaped card
  • the ring-shaped card includes a first curved card and a second curved card, and the inner walls of the first curved card and the second curved card are provided with a sealing pad;
  • One end of the first curved card is hinged to one end of the second curved card, and the other end of the first curved card is engaged with the other end of the second curved card.
  • the length of the lower needle of the dosing double needle is greater than the length of the upper needle.
  • the second preloaded hybrid device comprises a rotary sleeve, a guiding sleeve I, a guiding sleeve II, a guiding component, a filling cylinder and a dosing double needle; the dosing double needle is arranged in the charging cylinder ,
  • One end of the charging cartridge is an interface connecting end, and the other end is connected to one end of the guiding sleeve I;
  • the other end of the guiding sleeve I extends into the guiding sleeve II.
  • the side wall of the guiding sleeve I is provided with a guiding through groove in the axial direction, and both ends of the guiding through groove are opposite on the circumference of the guiding sleeve I. a direction extending a distance, the bottom end of the guiding groove extending in the direction of the circumference of the guiding sleeve I and the rotation direction of the rotating sleeve when pushing the medicine container;
  • the inner wall of the guiding sleeve II is provided with a guiding spiral groove, and the guiding sleeve II is connected with one end of the rotating sleeve;
  • the guiding member is disposed in the guiding sleeve 1.
  • the outer side of the guiding member has a guiding block.
  • the guiding block passes through the guiding through groove and extends into the guiding spiral groove, so that the rotating sleeve and the guiding sleeve I form an axial fixed and radial direction. Rotating fit.
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is corresponding to the dosing; the one end of the guiding cylinder is open, and the open end of the guiding cylinder and the dosing double
  • the inner cavity of the guiding cylinder is a drug container accommodating cavity.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve II.
  • the inner wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed against the other end of the guide sleeve 1 and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve 1 through the sealing ring.
  • two guiding spiral grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves are arranged symmetrically on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically arranged
  • the adding cartridge is integrally formed with the guiding sleeve I.
  • the inner wall of the charging cartridge is symmetrically disposed with at least two anti-slip buckles in the shape of a barb and used to prevent loosening of the drug container.
  • annular rubber pad is disposed on the inner wall of the charging cartridge and adjacent to the interface connecting end, and the needle tip corresponding to the connecting end of the dosing pin passes through the annular rubber pad.
  • the bottom end of the filling cartridge is provided with a snap-fit assembly for connecting the interface of the infusion container and the interface connection end.
  • the snap-fit component is a ring-shaped card
  • the ring-shaped card includes a first curved card and a second curved card, and the inner walls of the first curved card and the second curved card are provided with a sealing pad;
  • One end of the first curved card is hinged to one end of the second curved card, and the other end of the first curved card is engaged with the other end of the second curved card.
  • the length of the lower needle of the dosing double needle is greater than the length of the upper needle.
  • the third preloaded hybrid device comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II, a guiding component, a filling cylinder and a dosing double needle; the dosing double needle is arranged in the charging cylinder ,
  • One end of the feeding cartridge is an interface connecting end, and the other end is connected to one end of the guiding sleeve II, and the inner wall of the guiding sleeve II is provided with a guiding spiral through groove;
  • the other end of the guiding sleeve II extends into the guiding sleeve I, and the guiding sleeve I is connected with one end of the rotating sleeve;
  • the side wall of the guiding sleeve I is provided with a guiding groove in the axial direction, and the two ends of the guiding groove are
  • the circumference of the guide sleeve I extends in a direction opposite to the opposite direction, and the bottom end of the guide groove extends in the direction of the circumference of the guide sleeve I to coincide with the rotation direction of the rotary sleeve when the medicine container is pushed;
  • the guiding member is disposed in the guiding sleeve II.
  • the outer side of the guiding member has a guiding block.
  • the guiding block passes through the guiding spiral passage groove and extends into the guiding groove, so that the rotating sleeve and the guiding sleeve II are axially fixed and radial. Rotating fit.
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is corresponding to the dosing; the one end of the guiding cylinder is open, and the open end of the guiding cylinder and the dosing double
  • the inner cavity of the guiding cylinder is a drug container accommodating cavity.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve 1.
  • the inner wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on the other end of the guide sleeve II and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve II through the sealing ring.
  • two guiding spiral passage grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves disposed axially are symmetrically disposed on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically disposed
  • the adding cartridge is integrally formed with the guiding sleeve II.
  • the inner wall of the charging cartridge is symmetrically disposed with at least two anti-slip buckles in the shape of a barb and used to prevent loosening of the drug container.
  • annular rubber pad is disposed on the inner wall of the charging cartridge and adjacent to the interface connecting end, and the needle tip corresponding to the connecting end of the dosing pin passes through the annular rubber pad.
  • the bottom end of the filling cartridge is provided with a snap-fit assembly for connecting the interface of the infusion container and the interface connection end.
  • the snap-fit component is a ring-shaped card
  • the ring-shaped card includes a first curved card and a second curved card, and the inner walls of the first curved card and the second curved card are provided with a sealing pad;
  • One end of the first curved card is hinged to one end of the second curved card, and the other end of the first curved card is engaged with the other end of the second curved card.
  • the length of the lower needle of the dosing double needle is greater than the length of the upper needle.
  • the fourth preloaded drug mixture provided by the invention comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II, a guiding component, a filling cylinder and a dosing double needle; the dosing double needle is arranged in the charging cylinder ,
  • One end of the charging cartridge is an interface connecting end, and the other end is connected to one end of the guiding sleeve I;
  • a guiding groove is disposed on the side wall of the guiding sleeve I in the axial direction, and both ends of the guiding groove extend a certain distance in the opposite direction on the circumference of the guiding sleeve I, and the bottom end of the guiding groove is in the guiding sleeve
  • the direction of extension of the circumference of I coincides with the direction of rotation of the rotating sleeve when pushing the drug container;
  • One end of the guiding sleeve II extends into the guiding sleeve I, and the other end of the guiding sleeve II is connected with one end of the rotating sleeve; the inner wall of the guiding sleeve II is provided with a guiding spiral through groove;
  • the guiding member is disposed in the guiding sleeve II.
  • the outer side of the guiding member has a guiding block.
  • the guiding block passes through the guiding spiral passage groove and extends into the guiding groove, so that the rotating sleeve and the guiding sleeve I form an axial fixed and radial direction. Rotating fit.
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is corresponding to the dosing; the one end of the guiding cylinder is open, and the open end of the guiding cylinder and the dosing double
  • the inner cavity of the guiding cylinder is a drug container accommodating cavity.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve II.
  • the outer wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on the other end of the guide sleeve 1 and is rotationally and sealingly engaged therewith.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve 1 through the sealing ring.
  • two guiding spiral passage grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves disposed axially are symmetrically disposed on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically disposed
  • the adding cartridge is integrally formed with the guiding sleeve I.
  • the inner wall of the charging cartridge is symmetrically disposed with at least two anti-slip buckles in the shape of a barb and used to prevent loosening of the drug container.
  • annular rubber pad is disposed on the inner wall of the charging cartridge and adjacent to the interface connecting end, and the needle tip corresponding to the connecting end of the dosing pin passes through the annular rubber pad.
  • the bottom end of the filling cartridge is provided with a snap-fit assembly for connecting the interface of the infusion container and the interface connection end.
  • the snap-fit component is a ring-shaped card
  • the ring-shaped card includes a first curved card and a second curved card, and the inner walls of the first curved card and the second curved card are provided with a sealing pad;
  • One end of the first curved card is hinged to one end of the second curved card, and the other end of the first curved card is engaged with the other end of the second curved card.
  • the length of the lower needle of the dosing double needle is greater than the length of the upper needle.
  • the pushing device used in the first preloaded hybrid device comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II and a guiding member; one end of the guiding sleeve I extends into the guiding sleeve II, and the guiding sleeve The other end of the guide sleeve I is connected to one end of the rotating sleeve; the side wall of the guiding sleeve I is provided with a guiding through groove in the axial direction, and both ends of the guiding through groove extend in opposite directions on the circumference of the guiding sleeve I.
  • the inner wall of the guiding sleeve II is provided with a guiding spiral groove;
  • the outer side of the guiding member has a guiding block, and the guiding block passes through the guiding through groove and protrudes into the guiding spiral groove, so that the rotating sleeve and the guiding sleeve II form an axial fixed and radial rotatably fit.
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is downward; one end of the guiding cylinder is open, and the open end of the guiding cylinder is downward, guiding the inner cavity of the cylinder
  • the chamber is housed in a drug container.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve 1.
  • the outer wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on the other end of the guide sleeve II and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve II through the sealing ring.
  • two guiding spiral grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves are arranged symmetrically on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically arranged
  • the pushing device used in the second preloaded hybrid device comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II and a guiding member; one end of the guiding sleeve I extends into the guiding sleeve II, A guiding through groove is arranged on the side wall of the guiding sleeve I in the axial direction, and both ends of the guiding through groove extend a certain distance in the opposite direction on the circumference of the guiding sleeve I, and the bottom end of the guiding through groove is guided
  • the direction of the sleeve I extends in the same direction as the rotation direction of the rotating sleeve when pushing the medicine container;
  • the inner wall of the guiding sleeve II is provided with a guiding spiral groove, and the guiding sleeve II is connected with one end of the rotating sleeve;
  • the guiding member is arranged on the guiding sleeve I, the outer
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is downward; one end of the guiding cylinder is open, and the open end of the guiding cylinder is downward, guiding the inner cavity of the cylinder
  • the chamber is housed in a drug container.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve II.
  • the inner wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed against the other end of the guide sleeve 1 and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with the other end of the guide sleeve 1 through the sealing ring.
  • two guiding spiral grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves are arranged symmetrically on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically arranged
  • the pushing device used in the third preloaded hybrid device comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II and a guiding member; one end of the guiding sleeve II extends into the guiding sleeve I,
  • the inner wall of the guiding sleeve II is provided with a guiding spiral through groove;
  • the guiding sleeve I is connected with one end of the rotating sleeve;
  • the side wall of the guiding sleeve I is provided with a guiding groove in the axial direction, and both ends of the guiding groove are in the guiding sleeve I Extending a distance in the opposite direction on the circumference, the bottom end of the guiding groove extending in the direction of the circumference of the guiding sleeve I and the rotating direction of the rotating sleeve when pushing the medicine container;
  • the guiding member is disposed in the guiding sleeve II
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is downward; one end of the guiding cylinder is open, and the open end of the guiding cylinder is downward, guiding the inner cavity of the cylinder
  • the chamber is housed in a drug container.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve 1.
  • the inner wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on one end of the guide sleeve II and is rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with one end of the guide sleeve II through a sealing ring.
  • two guiding spiral passage grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves disposed axially are symmetrically disposed on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically disposed
  • the pushing device used in the fourth pre-assembled mixing device comprises a rotating sleeve, a guiding sleeve I, a guiding sleeve II and a guiding member; one end of the guiding sleeve II extends into the guiding sleeve I, and the guiding sleeve The other end of the guiding sleeve II is connected with one end of the rotating sleeve; the inner wall of the guiding sleeve II is provided with a guiding spiral passage groove; the side wall of the guiding sleeve I is provided with a guiding groove in the axial direction, and both ends of the guiding groove are guided The circumference of the sleeve I extends a distance in an opposite direction, the bottom end of the guiding groove extending in the direction of the circumference of the guiding sleeve I and the rotation direction of the rotating sleeve when pushing the medicine container; the guiding member is arranged at the guiding In
  • the guiding member is a flat plate, a grab bucket, a guiding cylinder or a push rod; the opening of the grab bucket is downward; one end of the guiding cylinder is open, and the open end of the guiding cylinder is downward, guiding the inner cavity of the cylinder
  • the chamber is housed in a drug container.
  • the other end of the rotating sleeve is a sealed end.
  • the rotating sleeve is integrally formed with the guiding sleeve II.
  • the outer wall of the rotary sleeve is provided with a pressure ring in the circumferential direction, and the pressure ring is pressed on one end of the guide sleeve 1 and rotated and sealingly fitted thereto.
  • the pressure ring is sealingly engaged with one end of the guide sleeve I through a sealing ring.
  • two guiding spiral passage grooves are symmetrically disposed on the inner wall of the guiding sleeve II, and two guiding grooves disposed axially are symmetrically disposed on the side wall of the guiding sleeve I, and the outer side of the guiding member is symmetrically disposed
  • the invention has the beneficial effects that when the pre-filled drug mixture is used, the bottom of the drug cartridge is firstly docked with the interface on the infusion soft bag or the infusion soft bottle, and the drug container is pre-loaded under the guiding member or the guiding member. Inside, the guide sleeve II is sealingly butted against the top of the cartridge. The drug container and the dosing double needle are sealed by a septum in the interface and a rotating sleeve sealed at one end, so that absolute sterility of transport and storage can be achieved.
  • Figure 1 is a schematic view showing the structure of a first preloaded drug mixture
  • FIG. 2 is a schematic cross-sectional structural view of a charging cartridge in a first preloaded drug mixture
  • FIG. 3 is a schematic cross-sectional structural view of a guide sleeve II in the first preloaded drug mixture
  • FIG. 4 is a schematic cross-sectional structural view showing the guide sleeve II and the filling cylinder integrally formed in the first preloaded drug mixture;
  • Figure 5 is a front elevational view showing the rotary sleeve and the guide sleeve I integrally formed in the first preloaded drug mixture;
  • Figure 6 is a cross-sectional view taken along line A-A of Figure 5;
  • Figure 7 is a schematic cross-sectional view showing the guiding member of the first preloaded type mixing device using a guiding cylinder
  • Figure 8 is a schematic view showing the structure of a first preloaded type mixing device using a guiding cylinder for a guiding member
  • FIG. 9 is a schematic cross-sectional structural view of a guide member in a first preloaded drug mixture using a push rod
  • Figure 10 is a perspective view showing the three-dimensional structure of the guide member in the first type of preloaded drug mixture using a push rod;
  • Figure 11 is a schematic view showing the structure of the snap-fit assembly in the first pre-filled drug mixture
  • Figure 12 is a schematic view showing the structure of the first pre-filled mixer using the push rod of the guiding member connected to the infusion container and before use;
  • Figure 13 is a schematic view showing the structure of the first pre-filled mixer using the push rod of the guiding member connected to the infusion container and in use;
  • Figure 14 is a schematic view showing the structure of the first pre-filled mixer using the guide cylinder connected to the infusion container and in use;
  • Figure 15 is a schematic view showing the structure of the pushing device used on the first preloaded type mixing device using the guiding cylinder for the guiding member;
  • Figure 16 is a schematic view showing the structure of a pushing device used on a first preloaded type mixing device using a push rod;
  • Figure 17 is a schematic view showing the structure of a second preloaded drug mixture
  • Figure 18 is a front elevational view showing the rotary sleeve and the guide sleeve II integrally formed in the second preloaded drug mixture;
  • Figure 19 is a cross-sectional view taken along line B-B of Figure 18;
  • Figure 20 is a schematic view showing the structure of the guide sleeve I in the second preloaded drug mixture
  • Figure 21 is a cross-sectional structural view showing the molding of the cartridge and the guide sleeve I in the second preloaded drug mixture
  • Figure 22 is a schematic view showing the structure of the second pre-assembled type mixing device using the push rod of the guiding member connected to the infusion container and before use;
  • Figure 23 is a schematic view showing the structure of the second pre-assembled type mixing device using the push rod of the guiding member connected to the infusion container and in use;
  • Figure 24 is a schematic view showing the structure of the second pre-assembled type mixing device with the guiding member connected to the infusion container and in use;
  • Figure 25 is a schematic view showing the structure of a pushing device used on a second preloaded type mixing device using a guiding cylinder;
  • Figure 26 is a schematic view showing the structure of a pushing device used on a second preloaded type mixing device using a push rod;
  • Figure 27 is a schematic view showing the structure of a third preloaded drug mixture
  • Figure 28 is a front elevational view showing the guide sleeve I and the rotary sleeve integrally formed in the third preloaded drug mixture;
  • Figure 29 is a cross-sectional view taken along line C-C of Figure 28;
  • Figure 30 is a schematic view showing the structure of the guide sleeve II in the third preloaded drug mixture
  • Figure 31 is a cross-sectional structural view showing the molding of the cartridge and the guide sleeve II in the third preloaded drug mixture;
  • Figure 32 is a schematic view showing the structure of the third pre-filled mixer using the push rod of the guiding member connected to the infusion container and before use;
  • Figure 33 is a schematic view showing the structure of the third pre-filled mixer using the push rod of the guiding member connected to the infusion container and in use;
  • Figure 34 is a schematic view showing the structure of the third pre-assembled type mixing device with the guiding member connected to the infusion container and in use;
  • Figure 35 is a schematic view showing the structure of a pushing device used on a third pre-filled mixer using a guiding cylinder;
  • Figure 36 is a schematic view showing the structure of a pushing device used on a third pre-filled mixer using a push rod;
  • Figure 37 is a schematic view showing the structure of a fourth preloaded drug mixture
  • Figure 38 is a front elevational view showing the guide sleeve II and the rotary sleeve integrally formed in the fourth preloaded drug mixture;
  • Figure 39 is a cross-sectional view taken along line D-D of Figure 38;
  • Figure 40 is a schematic structural view of a guide sleeve I in a fourth preloaded drug mixture
  • Figure 41 is a cross-sectional structural view showing the molding of the cartridge and the guide sleeve I in the fourth preloaded drug mixture.
  • Figure 42 is a schematic view showing the structure of the fourth pre-filled mixer using the push rod of the guiding member connected to the infusion container and before use;
  • Figure 43 is a schematic view showing the structure of the fourth pre-assembled type mixing device using the push rod of the guiding member connected to the infusion container;
  • Figure 44 is a schematic view showing the structure of the fourth pre-assembled mixing device using the guiding cylinder connected to the infusion container;
  • Figure 45 is a schematic view showing the structure of a pushing device used on a fourth preloaded drug mixture in which the guiding member is guided by a guiding cylinder;
  • Figure 46 is a schematic view showing the structure of a pushing device used on a fourth preloaded drug-mixer in which the guide member is a pusher.
  • the preloaded mixing device comprises a rotating sleeve 4, a guiding sleeve I3, a guiding sleeve II6, a guiding member, a filling cylinder 1 and a dosing double needle 2.
  • the structure of the cartridge 1 is as shown in FIG. 2, the bottom end of the cartridge 1 is an interface connection end 25, and the inner wall of the interface connection end 25 is a shrink-out structure, which is more conducive to the infusion container 14 (ie, infusion soft The size of the interface of the bag or infusion soft bottle is matched.
  • the inner wall of the charging cartridge 1 and the interface connecting end 25 are provided with an annular rubber pad 12, and the double needle 2 is added.
  • the dosing double needle 2 of the embodiment adopts a cross needle, that is, the upper needle and the lower side of the dosing double needle 2
  • the needle and the double needle support base 15 are integrally formed, and the cutting plane along the axis of the dosing double needle is a "cross" structure) is disposed in the charging cartridge 1, and the lower needle tip of the dosing double needle 2 passes through the annular rubber pad 12 And stuck on the annular rubber pad 12, the double needle support seat 15 of the dosing double needle 2 is located above the annular rubber pad 12, and the length of the lower needle of the dosing double needle 2 is greater than the length of the upper needle.
  • At least two anti-slip clasps 16 are provided symmetrically on the inner wall of the cartridge 1 (in this embodiment, four anti-slip clasps are symmetrically disposed on the inner wall of the cartridge 1), and are mounted in the drug container 17 After entering the cartridge 1, when the drug container 17 is mixed with the infusion container 14 (as shown in FIG. 13), the cap of the drug container 17 is caught under the anti-slip buckle 16, and the anti-slip buckle 16 can effectively block The drug container 17 is retreated to ensure that the mixed drug proceeds smoothly.
  • the structure of the guiding sleeve II6 is as shown in FIG. 3, the bottom end of the guiding sleeve II6 is sealingly butted with the top end of the filling cylinder 1 (which can be connected by welding), and the inner wall of the guiding sleeve II6 is provided with a guiding spiral groove 7, the embodiment Two guide spiral grooves 7 are symmetrically disposed on the inner wall of the guide sleeve II6.
  • An annular card 18 is circumferentially disposed at the top of the inner wall of the guide sleeve II6, and an annular groove 19 is provided in the circumferential direction on the top end surface of the guide sleeve II6.
  • the guide sleeve II6 and the cartridge 1 can be integrally formed as shown in FIG.
  • the structure of the guide sleeve I3 and the rotary sleeve 4 is as shown in Figs. 5 and 6.
  • the guide sleeve I3 and the rotary sleeve 4 are integrally formed.
  • the guiding sleeve I3 extends into the guiding sleeve II6, and the top end of the guiding sleeve I3 is connected with the bottom end of the rotating sleeve 4 (butted by welding), and the rotating sleeve 4 and the guiding sleeve II6 form an axial fixed and radial rotation fit.
  • the rotating sleeve 4 is sealingly engaged with the guiding sleeve II6, and the top end of the rotating sleeve 4 is a sealed end.
  • a pressure ring 10 is provided on the outer wall of the rotary sleeve 4 in the circumferential direction, and an annular card groove 20 is provided in the circumferential direction below the pressure ring 10.
  • the guide sleeve I3 is provided with a guide groove 8 in the axial direction on the side wall of the guide sleeve I3. In the embodiment, two guide grooves 8 are arranged symmetrically on the side wall of the guide sleeve I3.
  • Both ends of the guide groove 8 extend in a reverse direction on the circumference of the guide sleeve I3 to form a "z"-shaped guide groove 8, and the bottom end of the guide groove 8 extends on the circumference of the guide sleeve I3.
  • the direction is the same as the direction of rotation of the rotary sleeve 4 when the drug container is pushed.
  • the guide block 9 on the guide member is located in the groove in the circumferential direction of the tip end of the guide groove 8, effectively preventing the guide member from being axially downward.
  • the guiding block 9 on the guiding member is located in the guiding channel 8
  • the groove in the circumferential direction of the bottom end effectively prevents the guide member from moving upward in the axial direction, thereby effectively preventing the drug container 17 from retreating, further ensuring smooth running of the mixed drug.
  • the guiding members are a flat plate, a grab bucket, a guide cylinder 5 or a push rod 26.
  • the guiding block 9 is disposed on both sides of the flat plate.
  • the drug container 17 only needs to be placed directly in the guiding sleeve I3 and under the flat plate, and the guiding block is arranged through the two sides of the flat plate. A downward directed movement is achieved, the plate is in contact with the drug container 17 and can directly push the drug container 17 downward.
  • the opening of the grab bucket is downward and corresponds to the dosing double needle 2
  • the guiding block 9 is symmetrically disposed on the outer wall on both sides of the grab bucket
  • the drug container 17 is pre-positioned when the dosing device is used.
  • the grab grips the drug container 17, and the downward guiding movement is realized by the guide blocks provided on the outer walls of the two sides of the grab, and the grab can directly push the medicine container 17 downward.
  • the guiding member adopts a guiding cylinder 5, one end of the guiding cylinder 5 is open, and the open end of the guiding cylinder 5 corresponds to the dosing double needle 2.
  • the inner cavity of the guiding cylinder 5 is a drug container accommodating cavity on the outer wall of the guiding cylinder 5.
  • Symmetrical two guiding blocks 9 are provided (as shown in Figures 7 and 8).
  • the guide member can also adopt a push rod 26.
  • the structure of the push rod 26 is as shown in FIG. 9 and FIG. 10, and the push rod 26 is disposed in the rotary sleeve 4 along the axial direction of the rotary sleeve 4.
  • the push rod 26 is open at the upper end and sealed at the lower end.
  • the hollow structure has a hollow structure in which the diameter of the upper inner hole is large and the diameter of the lower inner hole is small.
  • the bottom wall of the upper inner hole is uniformly provided with a vent hole 29 disposed in the axial direction. When the push rod 26 moves downward, the vent hole 29 facilitates the flow of gas in the lower space to the upper space, and the lower push rod 26 is lowered. Moved air resistance.
  • Two guide blocks 9 are symmetrically arranged on the outer wall of the push rod 26, one of the guide blocks 9 passes through a guide through groove 8 and projects into a guide spiral groove 7, and the other guide block 9 passes through the other guide through groove. 8 and into the other guiding spiral groove 7.
  • the push rod 26 is disposed in the rotating sleeve 4 along the axis of the rotating sleeve 4, and the upper needle tip of the dosing double needle 2 corresponds to the push rod 26, and after the medicine container 17 is placed in the filling tube 1, the bottom of the push rod 26 and the medicine
  • the top of the top of the container 17 corresponds to the upper needle tip of the dosing double needle 2 corresponding to the cap of the drug container 17.
  • the bottom of the interface connection end 25 is provided with a snap-fit assembly 24 (shown in Figures 11-14) for connecting the interface of the infusion container 14 with the interface connection end 25.
  • the snap-fit assembly 24 is a ring-shaped card.
  • the ring-shaped card includes a first curved card 241 and a second curved card 242.
  • the cross-sections of the first curved card 241 and the second curved card 242 are both concave structures.
  • a gasket 243 is disposed in the inner grooves of the curved card 241 and the second curved card 242.
  • One end of the first curved card 241 is hinged to one end of the second curved card 242, and the other end of the first curved card 241 is engaged with the other end of the second curved card 242.
  • the other end of the first curved card 241 and the other end of the second curved card 242 are overlapped and connected, that is, at the other end of the first curved card 241 and the second curved card 242.
  • the opposite end of the other end is provided with an undercut 244, and the other end of the first curved card 241 and the other end of the second curved card 242 are fastened to each other by the undercut 244 thereon (as shown in FIG. 11).
  • the first curved card 241 and the second curved card 242 are stuck on the annular boss at the bottom of the interface connecting end 25 and the annular boss on the interface 22, and the first curved card 241 and the second curved card 242 pass.
  • the undercuts 244 are snap-fitted to each other, and the interface connection end 25 of the cartridge 1 and the interface 22 on the infusion container 14 are sealed by a gasket 243 in the annular buckle 24.
  • a lifting ring 13 is provided through which the dosing device and the infusion container 14 connected to the dosing device (shown in Figures 12-14) are provided. Hang together on the support frame for infusion.
  • the bottom end of the cartridge 1 and the interface 22 on the infusion container 14 are firstly sealed by the snap-fit assembly 24 (also by soldering and screwing).
  • the infusion container 14 is an infusion soft bag, as shown in FIG. 12, the drug container 17 is pre-loaded into the cartridge 1 under aseptic conditions, through the septum 23 in the interface 22 and The top sealed swivel sleeve 4 places the drug container 17 and the dosing double needle 2 in a sealed state so that absolute sterility of transport and storage can be achieved.
  • the rotating sleeve 4 When mixing the medicine, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the push rod 26 to move down along the guiding spiral groove 7 on the inner wall of the guiding sleeve II6, and directly presses on the medicine container 17, thereby pushing the double needle 2 to move downward.
  • the upper needle tip of the dosing double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the dosing double needle 2 pierces the septum 23 in the interface 22, so that the drug container 17 and the infusion soft bag are instantaneously connected, as shown in FIG.
  • the entire process is in sterile docking, and the entire process is accomplished by rotating the swivel sleeve 4 to drive the push rod 26 down.
  • the lowering of the push rod 26 is achieved by the rotation of the rotary sleeve 4, so that the push rod 26 can be prevented from pressing the drug container 17 during transportation and storage.
  • the medicine container 17 is pushed until the cap is positioned below the anti-slip buckle 16, effectively preventing the drug container 17 from retreating, thereby ensuring the mixing.
  • the medicine went smoothly. Since the pre-filled drug dispenser is pre-loaded into the drug container until the infusion is completed, the drug container involved and the parts in direct contact with the drug are in a sterile state, so that the drug can be transported, stored, docked, and mixed.
  • the whole process of medicine and infusion is aseptically sealed.
  • the drug container 17 is placed in the drug cartridge 1 before and during the mixing. Since the drug cartridge 1 is made of a transparent material, the operator can observe the drug container 17 through the transparent drug cartridge 1.
  • the information of the drug to be dispensed helps the operator to grasp the information of the drug in time and avoid the mismatch of the drug.
  • the cartridge 1 can also adopt the structure of the mixed card body shown in FIG. 8 and FIG. 14 , and the guiding member adopts the guiding cylinder 5 , and the medicine container 17 is pre-loaded into the guiding cylinder 5 under aseptic conditions.
  • the drug container 17 and the dosing double needle 2 are sealed by the septum 23 in the interface 22 and the tip-sealed rotating sleeve 4, so that absolute sterility of transport and storage can be achieved.
  • the rotating sleeve 4 When the medicine is mixed, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the guiding cylinder 5 to move down along the guiding spiral groove 7 on the inner wall of the guiding sleeve II6, thereby driving the medicine container 17 in the guiding cylinder 5 to move downward, and the medicine container 17 is pressed.
  • the double needle 2 is applied and the dosing double needle 2 is driven down.
  • the upper needle tip of the dosing double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the dosing double needle 2 pierces the septum 23 in the interface 22.
  • the drug container 17 is instantaneously connected to the infusion soft bag as shown in FIG.
  • the drug container 17 is preloaded into the guide barrel 5, and the distance between the guide barrel 5 and the medicine container 17 is greatly shortened when the medicine is mixed (i.e., short-process mixing is achieved).
  • the pushing device used on the preloaded blender includes a rotating sleeve 4, a guide sleeve I3, a guide sleeve II6 and a guide member.
  • the guiding sleeve I3 extends into the guiding sleeve II6, the top end of the guiding sleeve I3 is connected with the bottom end of the rotating sleeve 4 (butted by welding), and the top end of the rotating sleeve 4 is sealed.
  • the rotating sleeve and the guiding sleeve I3 One piece.
  • the side wall of the guiding sleeve I3 is axially provided with a guiding through groove 8.
  • the two ends of the guiding groove 8 extend in a opposite direction on the circumference of the guiding sleeve I3, and the bottom end of the guiding groove 8 is in the guiding sleeve.
  • the direction of the extension of I3 coincides with the direction of rotation of the rotary sleeve 4 when the drug container is pushed; the inner wall of the guide sleeve II6 is provided with a guide spiral groove.
  • the guiding member is disposed in the guiding sleeve I3.
  • the guiding member has a guiding block 9 on the outer side thereof.
  • the guiding block 9 passes through the guiding through groove 8 and extends into the guiding spiral groove 7, so that the rotating sleeve 4 and the guiding sleeve II6 are axially fixed and diameter. Rotating fit.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the rotary sleeve 4, the guide sleeve I3, the guide sleeve II6, the guide cylinder 5 and the push rod 26 are the same as those in the first pre-filled mixer, and will not be described herein.
  • the guiding member When assembling the pushing device used on the pre-filled mixer, firstly, the guiding member (when the guiding member is guided by the guiding cylinder 5, as shown in Fig. 15; when the guiding member is the push rod 26, as shown in Fig. 16) is loaded.
  • the guiding block 9 on the guiding member passes through the guiding through groove 8 on the guiding sleeve I3, and pushes the guiding member to the connecting end of the guiding sleeve I3 and the rotating sleeve 7; then the guiding sleeve II6 is placed on the guiding sleeve
  • the guide block 9 on the guide member is inserted into the guide spiral groove 7 on the guide sleeve II6, and the rotary sleeve 4 is fastened to the top of the guide sleeve II6.
  • the pusher used in the first pre-filled blender is assembled in the same manner as the first pre-filled blender after being assembled with the cartridge and the dosing double needle. Let me repeat.
  • the preloaded blender includes a rotary sleeve 4, a guide sleeve I3, a guide sleeve II6, a guide member, a drug cartridge 1 and a dosing double needle 2.
  • the structure of the addition cartridge 1 and the dosing double needle 2 in the cartridge 1 is the same as that in the first preloaded mixer, and will not be described herein.
  • the structure of the guide sleeve II6 and the rotary sleeve 4 is as shown in Figs. 18 and 19.
  • the guide sleeve II6 and the rotary sleeve 4 are integrally formed, and the tip end of the rotary sleeve 4 is sealed.
  • the inner wall of the guide sleeve II6 is provided with a guiding spiral groove 7.
  • two guiding spiral grooves 7 are symmetrically arranged on the inner wall of the guiding sleeve II6.
  • a pressure ring 10 is provided on the inner wall of the rotary sleeve 4 in the circumferential direction, and an annular card groove 20 is provided in the circumferential direction below the pressure ring 10.
  • the structure of the guiding sleeve I3 is as shown in FIG. 20, the bottom end of the guiding sleeve I3 is sealingly butted with the top end of the filling cylinder 1 (which can be connected by welding), and the guiding sleeve I3 extends into the guiding sleeve II6, and the guiding sleeve I3
  • the top of the outer wall is provided with an annular card 18 in the circumferential direction, and an annular groove 19 is provided on the top end surface of the guide sleeve I3 in the circumferential direction.
  • the annular card 18 is located in the annular card slot 20, and a sealing ring 11 is mounted in the annular groove 19, and the pressure ring 10 is pressed against the guiding sleeve I3 through the sealing ring 11 and sealed therewith.
  • the rotating sleeve 4 is rotated, the ring-shaped card 18 rotates in the annular card slot 20, and the rotating sleeve 4 can be rotated on the guiding sleeve I3 due to the sealing action of the sealing ring 11, and the inner wall and the guiding sleeve of the rotating sleeve 4 can be realized.
  • the top of the I3 is sealed.
  • the guide sleeve I3 is provided with a guide groove 8 in the axial direction on the side wall of the guide sleeve I3.
  • two guide grooves 8 are arranged symmetrically on the side wall of the guide sleeve I3. Both ends of the guide groove 8 extend in a reverse direction on the circumference of the guide sleeve I3 to form a "z"-shaped guide groove 8, and the bottom end of the guide groove 8 extends on the circumference of the guide sleeve I3.
  • the direction is the same as the direction of rotation of the rotary sleeve 4 when the drug container is pushed.
  • the guide block 9 on the guide member is located in the groove in the circumferential direction of the tip end of the guide groove 8, effectively preventing the guide member from being axially downward. Moving, thereby preventing the guiding member from pushing the drug container 17 down before mixing; when the drug container 17 is mixed with the infusion container 14 (as shown in Figures 23 and 24), the guiding block 9 on the guiding member is located in the guiding channel 8 The groove in the circumferential direction of the bottom end effectively prevents the guide member from moving upward in the axial direction, thereby effectively preventing the drug container 17 from retreating, further ensuring smooth running of the mixed drug.
  • the guide sleeve I3 and the cartridge 1 can be integrally formed as shown in FIG.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the guiding cylinder 5 and the push rod 26 is the same as that of the first preloaded mixing device, and the mounting position and working principle of the flat plate, the grab bucket, the guiding cylinder or the push rod are mixed with the first preloaded type.
  • the installation position and working principle in the medicine device are the same, and will not be described here.
  • a snap-on assembly 24 is also provided at the bottom of the cartridge 1, and a sling 13 is provided on the top of the swivel sleeve 4.
  • the bottom end of the cartridge 1 and the interface 22 on the infusion container 14 are first sealedly connected by the snap-fit assembly 24, as shown in FIG.
  • the drug container 17 is pre-loaded into the cartridge 1 under aseptic conditions, and the drug container 17 and the dosing double needle 2 are sealed by the septum 23 in the interface 22 and the rotating sleeve 4 sealed at the tip end, thereby achieving transportation. And store absolute sterility.
  • the rotating sleeve 4 When mixing the medicine, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the push rod 26 to move down along the guiding groove 8 on the guiding sleeve I3, and directly presses on the medicine container 17, thereby pushing the double needle 2 to move downward, and then adding
  • the upper needle tip of the drug double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the drug double needle 2 pierces the diaphragm 23 in the interface 22, so that the drug container 17 and the infusion soft bag are instantaneously connected, as shown in FIG. Show .
  • the medicine container 17 is pushed until the cap is positioned below the anti-slip buckle 16, effectively preventing the drug container 17 from retreating, thereby ensuring the mixing.
  • the drug goes smoothly . Since the prefilled drug dispenser is pre-loaded into the drug container until the infusion is completed, the drug container involved and the components in direct contact with the drug are sterilized, therefore, It can realize the aseptic sealing of drugs in the whole process of transportation, storage, docking, mixing and infusion. .
  • the drug container 17 is placed in the drug cartridge 1 before and during the mixing. Since the drug cartridge 1 is made of a transparent material, the operator can observe the drug container 17 through the transparent drug cartridge 1. The information of the drug to be dispensed helps the operator to grasp the information of the drug in time and avoid the mismatch of the drug.
  • the cartridge 1 can also adopt the structure of the mixed card body shown in FIG. 24, and the guiding member adopts the guiding cylinder 5, and the medicine container 17 is pre-loaded into the guiding cylinder 5 under the sterile condition through the interface 22 in use.
  • the inner diaphragm 23 and the tip-sealed rotating sleeve 4 keep the drug container 17 and the dosing double needle 2 in a sealed state, so that absolute sterility of transportation and storage can be achieved.
  • the rotating sleeve 4 When the medicine is mixed, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the guiding cylinder 5 to move down along the guiding groove 8 on the guiding sleeve I3, thereby driving the medicine container 17 in the guiding cylinder 5 to move downward, and the medicine container 17 is pressed.
  • the medicine double needle 2 drives the medicine double needle 2 downward, and the upper needle tip of the medicine double needle 2 pierces the sealing plug on the medicine container 17, and the lower needle tip of the medicine double needle 2 pierces the diaphragm 23 in the interface 22,
  • the drug container 17 is brought into transient communication with the infusion soft bag as shown in FIG.
  • the drug container 17 is preloaded into the guide barrel 5, and the distance between the guide barrel 5 and the medicine container 17 is greatly shortened when the medicine is mixed (i.e., short-process mixing is achieved).
  • the pushing device used on the second preloaded blender includes a rotating sleeve 4, a guiding sleeve I3, a guiding sleeve II6 and a guiding member.
  • the guide sleeve I3 extends into the guide sleeve II6, and the guide sleeve I3 is provided with a guide groove 8 in the axial direction on the side wall of the guide sleeve I3.
  • two axially disposed guides are symmetrically disposed on the side wall of the guide sleeve I3.
  • the groove 8), the two ends of the guide groove 8 extend in a opposite direction on the circumference of the guide sleeve I3, and the bottom end of the guide groove 8 extends in the direction of the circumference of the guide sleeve I3 and pushes the drug container.
  • the rotation direction of the rotary sleeve 4 is uniform.
  • the top end of the rotary sleeve 4 is sealed, and the bottom end of the rotary sleeve 4 is connected to the top end of the guide sleeve II6 (butted by welding).
  • the guide sleeve II6 and the rotary sleeve 4 are integrally formed.
  • the guide member is disposed in the guide sleeve I3.
  • the guide member has a guide block 9 on the outer side thereof.
  • the guide block 9 passes through the guide groove 8 and extends into the guide spiral groove 7, so that the rotary sleeve 4 and the guide sleeve I3 form an axial fixed diameter. Rotating fit.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the rotary sleeve 4, the guide sleeve I3, the guide sleeve II6, the guide cylinder 5 and the push rod 26 is the same as that in the second preloaded mixer, and will not be described herein.
  • the guiding member When assembling the pushing device used on the pre-filled mixer, firstly, the guiding member (when the guiding member is guided by the guiding cylinder 5, as shown in Fig. 25; when the guiding member is the push rod 26, as shown in Fig. 26) is loaded.
  • the guiding sleeve II6 the guiding block 9 on the guiding member is inserted into the guiding spiral groove 7 on the guiding sleeve II6, and pushes the guiding member to the connecting end of the guiding sleeve II6 and the rotating sleeve 4; then the guiding sleeve I3 is inserted into the guiding sleeve II6.
  • the guide block 9 on the guide member is passed through the guide groove 8 on the guide sleeve I3, and the rotary sleeve 4 is fastened to the top of the guide sleeve I3.
  • the pushing device used in the second pre-filled mixer is mixed with the adding cartridge and the dosing double needle, and the mixing method is the same as the second pre-filled mixing device. Let me repeat.
  • the third preloaded blender includes a swivel sleeve 4, a guide sleeve I3, a guide sleeve II6, a guide member, a drug cartridge 1 and a dosing double needle 2.
  • the structure of the adding cartridge 1 and the dosing double needle 2 in the filling cartridge 1 is the same as that in the first pre-filled mixing device, and details are not described herein again.
  • the structure of the guide sleeve I3 and the rotary sleeve 4 is as shown in Figs. 28 and 29, and the top end of the guide sleeve I3 is connected to the bottom end of the rotary sleeve 4 (which can be butted by welding), and the top end of the rotary sleeve 4 is sealed.
  • the guide sleeve I3 and the rotary sleeve 4 are integrally formed.
  • a pressure ring 10 is provided on the inner wall of the rotary sleeve 4 in the circumferential direction, and an annular card groove 20 is provided in the circumferential direction below the pressure ring 10.
  • a guide groove 28 is disposed on the side wall of the guide sleeve I3 in the axial direction (in the embodiment, two circumferentially disposed guide grooves 28 are symmetrically disposed on the side wall of the guide sleeve I3). Both ends of the guiding groove 28 extend a certain distance in the opposite direction on the circumference of the guiding sleeve I3, and the bottom end of the guiding groove 28 extends in the direction of the circumference of the guiding sleeve I3 in accordance with the rotation direction of the rotating sleeve 4 when the medicine container is pushed. . Before the drug container 17 is mixed with the infusion container (as shown in FIG.
  • the guide block 9 on the guide member is located in the groove in the circumferential direction of the tip end of the guide groove 28, effectively preventing the guide member from moving downward from the axial direction.
  • the guiding member is prevented from pushing the medicine container 17 downward before the mixing; when the medicine container 17 is mixed with the infusion container 14 (as shown in Figs. 33 and 34), the guiding block 9 on the guiding member is located at the bottom end of the guiding groove 28.
  • the groove in the circumferential direction effectively prevents the guide member from moving upward in the axial direction, thereby effectively preventing the drug container 17 from retreating, further ensuring smooth running of the mixed drug.
  • the guiding sleeve II6 has the structure shown in Fig. 30, the guiding sleeve II6 is inserted into the guiding sleeve I3, and the inner wall of the guiding sleeve II6 is provided with a guiding spiral through groove 27. In this embodiment, two guiding spirals are symmetrically arranged on the inner wall of the guiding sleeve II6. Through slot 27.
  • the bottom end of the guiding sleeve II6 is sealingly butted against the top end of the filling cylinder 1 (which can be butted by welding), and an annular card 18 is circumferentially arranged on the top of the outer wall of the guiding sleeve II6, and the circumferential direction of the top end surface of the guiding sleeve II6
  • An annular groove 19 is provided.
  • the rotating sleeve 4 When the rotating sleeve 4 is rotated, the ring card 18 rotates in the annular card slot 20, and the rotating sleeve 4 can be rotated on the guiding sleeve II6 due to the sealing action of the sealing ring 11, and the inner wall and the guiding sleeve of the rotating sleeve 4 can be realized.
  • the top seal of the II6 When the rotating sleeve 4 is rotated, the ring card 18 rotates in the annular card slot 20, and the rotating sleeve 4 can be rotated on the guiding sleeve II6 due to the sealing action of the sealing ring 11, and the inner wall and the guiding sleeve of the rotating sleeve 4 can be realized.
  • the top seal of the II6 When the rotating sleeve 4 is rotated, the ring card 18 rotates in the annular card slot 20, and the rotating sleeve 4 can be rotated on the guiding sleeve II6 due
  • the guide sleeve II6 and the cartridge 1 can be integrally formed as shown in FIG.
  • the guiding member is disposed in the guiding sleeve II6.
  • the outer side of the guiding member has a guiding block 9.
  • the guiding block 9 passes through the guiding spiral through groove 27 and extends into the guiding groove 28, so that the rotating sleeve 4 and the guiding sleeve II6 are axially fixed and diameter. Rotating fit.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the guiding cylinder 5 and the push rod 26 is the same as that of the first preloaded mixing device, and the mounting position and working principle of the flat plate, the grab bucket, the guiding cylinder or the push rod are mixed with the first preloaded type.
  • the installation position and working principle in the medicine device are the same, and will not be described here.
  • a snap-on assembly 24 is also provided at the bottom of the cartridge 1, and a sling 13 is provided on the top of the swivel sleeve 4.
  • the bottom end of the cartridge 1 and the interface 22 on the infusion container 14 are first sealedly connected by the snap-fit assembly 24, as shown in FIG.
  • the drug container 17 is pre-loaded into the cartridge 1 under aseptic conditions, and the drug container 17 and the dosing double needle 2 are sealed by the septum 23 in the interface 22 and the rotating sleeve 4 sealed at the tip end, thereby achieving transportation. And store absolute sterility.
  • the rotating sleeve 4 drives the push rod 26 to move down along the guiding spiral through groove 27 on the inner wall of the guiding sleeve II6, and directly presses on the drug container 17, thereby pushing the dosing double needle 2 down.
  • the upper needle tip of the dosing double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the dosing double needle 2 pierces the diaphragm 23 in the interface 22, so that the drug container 17 and the infusion soft bag are instantaneously connected, as shown in the figure. 33 shows .
  • the guide block 9 on the push rod 26 is moved down into the groove in the circumferential direction of the bottom end of the guide groove 28, the medicine container 17 is pushed until the cap is positioned below the anti-slip buckle 16, effectively preventing the drug container 17 from retreating, thereby ensuring the mixed medicine. Smooth progress .
  • the drug container 17 is placed in the drug cartridge 1 before and during the mixing. Since the drug cartridge 1 is made of a transparent material, the operator can observe the drug container 17 through the transparent drug cartridge 1. The information of the drug to be dispensed helps the operator to grasp the information of the drug in time and avoid the mismatch of the drug.
  • the cartridge 1 can also adopt the structure of the mixed card body shown in FIG. 34, and the guiding member adopts the guiding cylinder 5, and the medicine container 17 is pre-loaded into the guiding cylinder 5 under the sterile condition through the interface 22 in use.
  • the inner diaphragm 23 and the tip-sealed rotating sleeve 4 keep the drug container 17 and the dosing double needle 2 in a sealed state, so that absolute sterility of transportation and storage can be achieved.
  • the rotating sleeve 4 When the medicine is mixed, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the guiding cylinder 5 to move down along the guiding spiral passage groove 27 on the inner wall of the guiding sleeve II6, thereby driving the medicine container 17 in the guiding cylinder 5 to move downward, and the medicine container 17 is pressed.
  • the upper needle tip of the dosing double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the dosing double needle 2 pierces the diaphragm in the interface 22 23, the drug container 17 and the infusion soft bag are instantaneously connected, as shown in FIG.
  • the drug container 17 is preloaded into the guide barrel 5, and the distance between the guide barrel 5 and the medicine container 17 is greatly shortened when the medicine is mixed (i.e., short-process mixing is achieved).
  • the pushing device used on the third preloaded blender includes a rotating sleeve 4, a guide sleeve I3, a guide sleeve II6, and a guide member.
  • the guiding sleeve II6 extends into the guiding sleeve I3, and the inner wall of the guiding sleeve II6 is provided with a guiding spiral through groove 27 (in the embodiment, the inner wall of the guiding sleeve II6 is symmetrically provided with two guiding spiral through grooves 27).
  • the top end of the guide sleeve I3 is connected to the bottom end of the rotary sleeve 4 (butted by welding).
  • the guide sleeve I3 and the rotary sleeve 4 are integrally formed.
  • a guiding groove 28 is disposed on the side wall of the guiding sleeve I3 in the axial direction (in the embodiment, two axially disposed guiding grooves 28 are symmetrically disposed on the side wall of the guiding sleeve I3), and the two ends of the guiding groove 28 are
  • the circumference of the guide sleeve I3 extends in the opposite direction for a distance, and the bottom end of the guide groove 28 extends in the direction of the circumference of the guide sleeve I3 in conformity with the direction of rotation of the rotary sleeve 4 when the medicine container is pushed.
  • the guiding member is disposed in the guiding sleeve II6.
  • the outer side of the guiding member has a guiding block 9.
  • the guiding block 9 passes through the guiding spiral through groove 27 and extends into the guiding groove 28, so that the rotating sleeve 4 and the guiding sleeve II6 are axially fixed and diameter. Rotating fit.
  • the guide member When assembling the pushing device used on the pre-filled mixer, first, the guide member (when the guide member is guided by the guide cylinder 5, as shown in Fig. 35; when the guide member is the push rod 26, as shown in Fig. 36) is loaded.
  • the guiding block 9 on the guiding member In the guiding sleeve I3, the guiding block 9 on the guiding member is inserted into the guiding groove 28 on the guiding sleeve I3, and pushes the guiding member to the connecting end of the guiding sleeve I3 and the rotating sleeve 4; then the guiding sleeve II6 is inserted into the guiding sleeve I3.
  • the guide block 9 on the guide member is passed through the guide spiral passage groove 27 on the guide sleeve II6, and the rotary sleeve 4 is fastened to the top of the guide sleeve II6.
  • the pusher used in the third pre-filled blender is mixed with the cartridge and the dosing double-needle, and the hybrid is the same as the third pre-filled blender. Let me repeat.
  • the preloaded blender includes a rotary sleeve 4, a guide sleeve I3, a guide sleeve II6, a guide member, a drug cartridge 1 and a dosing double needle 2.
  • the structure of the adding cartridge 1 and the dosing double needle 2 in the filling cartridge 1 is the same as that in the first pre-filled mixing device, and details are not described herein again.
  • the structure of the guide sleeve II6 and the rotary sleeve 4 is as shown in Figs. 38 and 39, and the top end of the guide sleeve II6 is connected to the bottom end of the rotary sleeve 4 (which can be butted by welding).
  • the guide sleeve II6 and the rotary sleeve 4 are integrally formed, and the tip end of the rotary sleeve 4 is sealed.
  • the inner wall of the guiding sleeve II6 is provided with a guiding spiral through groove 27.
  • two guiding spiral through grooves 27 are symmetrically arranged on the inner wall of the guiding sleeve II6.
  • a pressure ring 10 is provided on the outer wall of the rotary sleeve 4 in the circumferential direction, and an annular card groove 20 is provided circumferentially below the pressure ring 10.
  • the structure of the guiding sleeve I3 is as shown in Fig. 40, the bottom end of the guiding sleeve I3 is sealingly butted with the top end of the filling cartridge 1 (which can be connected by welding), and the guiding sleeve II6 extends into the guiding sleeve I3, and the guiding sleeve I3
  • the top of the inner wall is provided with an annular card 18 in the circumferential direction, and an annular groove 19 is provided in the circumferential direction on the top end surface of the guide sleeve I3.
  • the annular card 18 is located in the annular card slot 20, and a sealing ring 11 is mounted in the annular groove 19, and the pressure ring 10 is pressed against the guiding sleeve I3 through the sealing ring 11 and sealed therewith.
  • the rotating sleeve 4 is rotated, the ring-shaped card 18 rotates in the annular card slot 20, and the rotating sleeve 4 can be rotated on the guiding sleeve I3 due to the sealing action of the sealing ring 11, and the outer wall and the guiding sleeve of the rotating sleeve 4 can be realized.
  • the top of the I3 is sealed.
  • a guide groove 28 is disposed on the side wall of the guide sleeve I3 in the axial direction (in the embodiment, two axially disposed guide grooves 28 are symmetrically disposed on the side wall of the guide sleeve I3). Both ends of the guiding groove 28 extend a certain distance in the opposite direction on the circumference of the guiding sleeve I3 to form a "z"-shaped guiding groove 28, and the bottom end of the guiding groove 28 extends in the direction and pushing of the circumference of the guiding sleeve I3.
  • the rotation direction of the rotary sleeve 4 is the same when the medicine container is used. Before the drug container 17 is mixed with the infusion container 14 (as shown in Fig.
  • the guide block 9 on the guide member is located in the groove in the circumferential direction of the tip end of the guide groove 28, effectively preventing the guide member from moving downward from the axial direction.
  • the guiding member is prevented from pushing the medicine container 17 downward before the mixing; when the medicine container 17 is mixed with the infusion container 14 (as shown in FIGS. 43 and 44), the guiding block 9 on the guiding member is located at the bottom of the guiding groove 28.
  • the groove in the circumferential direction effectively prevents the guide member from moving upward in the axial direction, thereby effectively preventing the drug container 17 from retreating, further ensuring smooth running of the mixed drug.
  • the guide sleeve I3 and the cartridge 1 can be integrally formed as shown in FIG.
  • the guide member is disposed in the guide sleeve II6.
  • the guide member has a guide block 9 on the outer side thereof.
  • the guide block 9 passes through the guide spiral passage groove 27 and extends into the guide groove 28, so that the rotary sleeve 4 and the guide sleeve I3 form an axial fixed diameter. Rotating fit.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the guiding cylinder 5 and the push rod 26 is the same as that of the first preloaded mixing device, and the mounting position and working principle of the flat plate, the grab bucket, the guiding cylinder or the push rod are mixed with the first preloaded type.
  • the installation position and working principle in the medicine device are the same, and will not be described here.
  • a snap-on assembly 24 is also provided at the bottom of the cartridge 1, and a sling 13 is provided on the top of the swivel sleeve 4.
  • the bottom end of the cartridge 1 and the interface 22 on the infusion container 14 are first sealedly connected by the snap-fit assembly 24, as shown in FIG.
  • the drug container 17 is pre-loaded into the cartridge 1 under aseptic conditions, and the drug container 17 and the dosing double needle 2 are sealed by the septum 23 in the interface 22 and the rotating sleeve 4 sealed at the tip end, thereby achieving transportation. And store absolute sterility.
  • the rotating sleeve 4 When the medicine is mixed, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the push rod 26 to move down along the guiding groove 28 on the inner wall of the guiding sleeve I3, and directly presses on the medicine container 17, thereby pushing the dosing double needle 2 down, and adding
  • the upper needle tip of the drug double needle 2 pierces the sealing plug on the drug container 17, and the lower needle tip of the drug double needle 2 pierces the diaphragm 23 in the interface 22, so that the drug container 17 and the infusion soft bag are instantaneously connected, as shown in FIG. Show .
  • the medicine container 17 is pushed until the cap is positioned below the anti-slip buckle 16, effectively preventing the drug container 17 from retreating, thereby ensuring the mixed medicine. Smooth progress . Since the prefilled drug dispenser is pre-loaded into the drug container until the infusion is completed, the drug container involved and the components in direct contact with the drug are sterilized, therefore, It can realize the aseptic sealing of drugs in the whole process of transportation, storage, docking, mixing and infusion. .
  • the drug container 17 is placed in the drug cartridge 1 before and during the mixing. Since the drug cartridge 1 is made of a transparent material, the operator can observe the drug container 17 through the transparent drug cartridge 1. The information of the drug to be dispensed helps the operator to grasp the information of the drug in time and avoid the mismatch of the drug.
  • the cartridge 1 can also adopt the structure of the mixed card body shown in Fig. 44, and the guiding member adopts the guiding cylinder 5, and the medicine container 17 is pre-loaded into the guiding cylinder 5 under the sterile condition through the interface 22 in use.
  • the inner diaphragm 23 and the tip-sealed rotating sleeve 4 keep the drug container 17 and the dosing double needle 2 in a sealed state, so that absolute sterility of transportation and storage can be achieved.
  • the rotating sleeve 4 When the medicine is mixed, the rotating sleeve 4 is rotated, and the rotating sleeve 4 drives the guiding cylinder 5 to move down along the guiding groove 28 on the inner wall of the guiding sleeve I3, thereby driving the medicine container 17 in the guiding cylinder 5 to move downward, and the medicine container 17 is pressed.
  • the medicine double needle 2 drives the medicine double needle 2 downward, and the upper needle tip of the medicine double needle 2 pierces the sealing plug on the medicine container 17, and the lower needle tip of the medicine double needle 2 pierces the diaphragm 23 in the interface 22,
  • the drug container 17 is brought into transient communication with the infusion soft bag as shown in FIG.
  • the drug container 17 is preloaded into the guide barrel 5, and the distance between the guide barrel 5 and the medicine container 17 is greatly shortened when the medicine is mixed (i.e., short-process mixing is achieved).
  • the pushing device used on the preloaded blender includes a rotating sleeve 4, a guide sleeve I3, a guide sleeve II6 and a guide member.
  • the guiding sleeve II6 extends into the guiding sleeve I3, and the top end of the guiding sleeve II6 is connected with the bottom end of the rotating sleeve 4 (butted by welding).
  • the inner wall of the guide sleeve II6 is provided with a guiding spiral through groove 27 (in this embodiment, the inner wall of the guiding sleeve II6 is symmetrically provided with two guiding spiral through grooves 27).
  • the guiding sleeve II6 and the rotating sleeve 4 are integrally formed.
  • a guiding groove 28 is disposed on the side wall of the guiding sleeve I3 in the axial direction (in the embodiment, two axially disposed guiding grooves 28 are symmetrically disposed on the side wall of the guiding sleeve I3), and the two ends of the guiding groove 28 are
  • the circumference of the guide sleeve I3 extends in the opposite direction for a distance, and the bottom end of the guide groove 28 extends in the direction of the circumference of the guide sleeve I3 in conformity with the direction of rotation of the rotary sleeve 4 when the medicine container is pushed.
  • the guide member is disposed in the guide sleeve II6.
  • the guide member has a guide block 9 on the outer side thereof. The guide block 9 passes through the guide spiral passage groove 27 and extends into the guide groove 28, so that the rotary sleeve 4 and the guide sleeve I3 form an axial fixed diameter. Rotating fit.
  • the guiding members are flat plates, grabs, guide cylinders or push rods.
  • the structure of the rotary sleeve 4, the guide sleeve I3, the guide sleeve II6, the guide cylinder 5 and the push rod 26 is the same as that in the fourth pre-filled mixer, and will not be described herein.
  • the guiding member When assembling the pushing device used on the pre-filled mixer, firstly, the guiding member (when the guiding member is guided by the guiding cylinder 5, as shown in Fig. 45; when the guiding member is the push rod 26, as shown in Fig. 46) is loaded.
  • the guiding sleeve II6 the guiding block 9 on the guiding member passes through the guiding spiral through groove 27 on the guiding sleeve II6, and pushes the guiding member to the connecting end of the guiding sleeve II6 and the rotating sleeve 4; then the guiding sleeve I3 is placed on the guiding end.
  • the guide block 9 on the guide member On the sleeve II6, the guide block 9 on the guide member is inserted into the guide groove 28 of the guide sleeve I3, and the rotary sleeve 4 is fastened to the top of the guide sleeve I3.
  • the pusher used in the fourth pre-filled blender is assembled in the same manner as the cartridge and the dosing double-needle, and the fourth pre-filled blender is mixed. Let me repeat.

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Abstract

一种预装式混药器，包括旋转套（4）、导向套I（3）、导向套II（6）、导向部件、加药筒（1）和加药双针（2）；导向套I（3）伸入导向套II（6）内并与旋转套（4）连接，导向套I（3）的侧壁上设有导向通槽（8），导向通槽（8）的两端向相反方向延伸出一段距离，导向套II（6）的内壁设置导向螺旋槽（7）；导向部件设在导向套I（3）内，其外侧具有导向块（9），导向块（9）穿过导向通槽（8）并伸进导向螺旋槽（7）内。使用时，转动旋转套（4）驱动导向部件迅速下移并推动药物容器（17），加药双针（2）的上针尖刺穿药物容器（17）上的密封塞，下针尖刺破接口（22）内的隔膜（23），使药物容器（17）与输液容器（14）瞬间连通，可实现运输、储存、对接、混药及输液的全过程无菌密闭。

Description

预装式混药器
技术领域
本发明涉及一种医疗器械，尤其涉及一种混药时使用的混药器。
背景技术
为了将药物容器内的药物加入输液容器（即输液软袋或输液软瓶）内的溶液中，然后将混合溶液输入诸如医院的临床机构中的病人。现有技术中，常采用加药器将药物容器与输液软袋或输液软瓶连接。
现有技术中的加药器主要包括加药筒和加药双针，加药筒形成杯状结构，加药双针通过双针支撑座卡在加药筒内，为了对混药通道进行密封，在加药筒的底部内壁横截面上设有隔膜，在加药筒的顶端设有密封膜，加药双针的一针尖与隔膜对应，加药双针的另一针尖与上方的密封膜对应。使用时，将该加药筒与输液软袋或输液软瓶的接口对接，撕开加药筒顶端上的密封膜，再将药物容器卡入加药筒内，药物容器卡入的同时也推动加药双针下移，加药双针的上针尖刺穿药物容器上的密封塞，加药双针的下针刺破隔膜并刺穿输液软袋或输液软瓶上的接口上的密封塞，挤压输液软袋或输液软瓶便可实现混药。
采用上述结构的加药器，在混药过程中主要存在如下不足：在药物容器卡入加药筒内时，必须先撕开加药筒顶端上的密封膜，而且卡入时加药筒会与外界接触，进而造成污染。而 现有技术中出现的所有的密闭式加药器，均只能实现在混药过程的密闭，而不能实现药物容器与加药器的对接、混药及输液时的"全过程无菌密闭" 。
发明内容
针对现有技术中存在的上述不足，本发明提供了一种可在完全无菌状态下运输、储存、对接、混药及输液 全过程密闭的 预装式混药器 。
同时本发明还提供了一种 可在完全无菌状态下对接、混药及输液 全过程密闭的 预装式混药器上使用的推动装置。
为了解决上述技术问题，本发明采用了如下技术方案：
本发明提供的第一种预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，
所述导向套Ⅰ的一端伸入导向套Ⅱ内，导向套Ⅰ的另一端与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
所述加药筒的一端为接口连接端，另一端与导向套Ⅱ的一端连接；所述导向套Ⅱ的内壁设置导向螺旋槽；
所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口与加药双针对应；所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅰ一体成型。
进一步，所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
进一步，所述加药筒与导向套Ⅱ一体成型。
进一步，所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
进一步，所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
进一步，所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
进一步，所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
进一步，所述加药双针的下针的长度大于上针的长度。
本发明提供的第二种预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，
所述加药筒的一端为接口连接端，另一端与导向套Ⅰ的一端连接；
所述导向套Ⅰ的另一端伸入导向套Ⅱ内，所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
所述导向套Ⅱ的内壁设置导向螺旋槽，导向套Ⅱ与旋转套的一端连接；
所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口与加药双针对应；所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅱ一体成型。
进一步，所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
进一步，所述加药筒与导向套Ⅰ一体成型。
进一步，所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
进一步，所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
进一步，所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
进一步，所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
进一步，所述加药双针的下针的长度大于上针的长度。
本发明提供的第三种预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，
所述加药筒的一端为接口连接端，另一端与导向套Ⅱ的一端连接，所述导向套Ⅱ的内壁设置导向螺旋通槽；
所述导向套Ⅱ的另一端伸入导向套Ⅰ内，导向套Ⅰ与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口与加药双针对应；所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅰ一体成型。
进一步，所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
进一步，所述加药筒与导向套Ⅱ一体成型。
进一步，所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
进一步，所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
进一步，所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
进一步，所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
进一步，所述加药双针的下针的长度大于上针的长度。
本发明提供的第四种预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，
所述加药筒的一端为接口连接端，另一端与导向套Ⅰ的一端连接；
所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
所述导向套Ⅱ的一端伸入导向套Ⅰ内，导向套Ⅱ的另一端与旋转套的一端连接；所述导向套Ⅱ的内壁设置导向螺旋通槽；
所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口与加药双针对应；所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅱ一体成型。
进一步，所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动密封配合。
进一步，所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
进一步，所述加药筒与导向套Ⅰ一体成型。
进一步，所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
进一步，所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
进一步，所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
进一步，所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
进一步，所述加药双针的下针的长度大于上针的长度。
本发明提供的第一种预装式混药器上使用的推动装置，包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅰ的一端伸入导向套Ⅱ内，导向套Ⅰ的另一端与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向套Ⅱ的内壁设置导向螺旋槽；所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口向下；所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅰ一体成型。
进一步，所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
本发明提供的第二种预装式混药器上使用的推动装置，包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅰ的一端伸入导向套Ⅱ内，所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向套Ⅱ的内壁设置导向螺旋槽，导向套Ⅱ与旋转套的一端连接；所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口向下；所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅱ一体成型。
进一步，所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
本发明提供的第三种预装式混药器上使用的推动装置，包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅱ的一端伸入导向套Ⅰ内，所述导向套Ⅱ的内壁设置导向螺旋通槽；导向套Ⅰ与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口向下；所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅰ一体成型。
进一步，所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅱ的一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅱ的一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
本发明提供的第四种预装式混药器上使用的推动装置，包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅱ的一端伸入导向套Ⅰ内，导向套Ⅱ的另一端与旋转套的一端连接；所述导向套Ⅱ的内壁设置导向螺旋通槽；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
进一步，所述导向部件为平板、抓斗、导向筒或推杆；所述抓斗的开口向下；所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
进一步，所述旋转套的另一端为密封端。
进一步，所述旋转套与导向套Ⅱ一体成型。
进一步，所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅰ的一端上并与其转动、且密封配合。
进一步，所述压环通过密封圈与导向套Ⅰ的一端密封配合。
进一步，所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
本发明的有益效果是：使用该预装式混药器时，先将加药筒的底部与输液软袋或输液软瓶上的接口对接，将药物容器预装入导向部件的下方或导向部件内，再将导向套Ⅱ与加药筒的顶部密封对接。通过接口内的隔膜和一端密封的旋转套使药物容器和加药双针处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套驱动导向部件沿导向套Ⅰ 上设置的导向槽或导向套Ⅱ上设置的导向螺旋槽迅速下移，进而带动导向部件下方或导向部件内的药物容器下移，药物容器施压在加药双针上并驱动加药双针下移，加药双针的上针尖刺穿药物容器上的密封塞，加药双针的下针尖刺破接口内的隔膜，使药物容器与输液软袋或输液软瓶内瞬间连通，整个过程均处于 无菌对接，因此，该 预装式混药器可实现运输、储存、对接、混药及输液的 全过程无菌密闭 。
附图说明
图1为第一种预装式混药器的结构示意图；
图2为第一种预装式混药器中的加药筒的剖面结构示意图；
图3为第一种预装式混药器中的导向套Ⅱ的剖面结构示意图；
图4为第一种预装式混药器中的导向套Ⅱ和加药筒一体成型的剖面结构示意图；
图5为第一种预装式混药器中的旋转套和导向套Ⅰ一体成型的主视图；
图6为图5中沿A-A方向的剖面视图；
图7为第一种预装式混药器中的导向部件采用导向筒的剖面结构示意图；
图8为导向部件采用导向筒的第一种预装式混药器的结构示意图；
图9为第一种预装式混药器中的导向部件采用推杆的剖面结构示意图；
图10为第一种预装式混药器中的导向部件采用推杆的立体结构示意图；
图11为第一种预装式混药器中的卡接组件的结构示意图；
图12为导向部件采用推杆的第一种预装式混药器连接在输液容器上、且处于使用前的结构示意图；
图13为导向部件采用推杆的第一种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图14为导向部件采用导向筒的第一种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图15为导向部件采用导向筒的第一种预装式混药器上使用的推动装置的结构示意图；
图16为导向部件采用推杆的第一种预装式混药器上使用的推动装置的结构示意图；
图17为第二种预装式混药器的结构示意图；
图18为第二种预装式混药器中的旋转套与导向套Ⅱ一体成型的主视图；
图19为图18中沿B-B方向的剖面视图;
图20为第二种预装式混药器中的导向套Ⅰ的结构示意图；
图21为第二种预装式混药器中的加药筒与导向套 Ⅰ一体 成型的剖面结构示意图；
图22为导向部件采用推杆的第二种预装式混药器连接在输液容器上、且处于使用前的结构示意图；
图23为导向部件采用推杆的第二种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图24为导向部件采用导向筒的第二种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图25为导向部件采用导向筒的第二种预装式混药器上使用的推动装置的结构示意图；
图26为导向部件采用推杆的第二种预装式混药器上使用的推动装置的结构示意图；
图27为第三种预装式混药器的结构示意图；
图28为第三种预装式混药器中的导向套Ⅰ与旋转套一体成型的主视图；
图29为图28中沿C-C方向的剖面视图；
图30为第三种预装式混药器中的导向套Ⅱ的结构示意图；
图31为第三种预装式混药器中的加药筒与导向套Ⅱ 一体 成型的剖面结构示意图；
图32为导向部件采用推杆的第三种预装式混药器连接在输液容器上、且处于使用前的结构示意图；
图33为导向部件采用推杆的第三种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图34为导向部件采用导向筒的第三种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图35为导向部件采用导向筒的第三种预装式混药器上使用的推动装置的结构示意图；
图36为导向部件采用推杆的第三种预装式混药器上使用的推动装置的结构示意图；
图37为第四种预装式混药器的结构示意图；
图38为第四种预装式混药器中的导向套Ⅱ与旋转套一体成型的主视图；
图39为图38中沿D-D方向的剖面视图；
图40为第四种预装式混药器中的导向套Ⅰ的结构示意图；
图41为第四种预装式混药器中的加药筒与导向套Ⅰ 一体 成型的剖面结构示意图
图42为导向部件采用推杆的第四种预装式混药器连接在输液容器上、且处于使用前的结构示意图；
图43为导向部件采用推杆的第四种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图44为导向部件采用导向筒的第四种预装式混药器连接在输液容器上、且处于使用时的结构示意图；
图45为导向部件采用导向筒的第四种预装式混药器上使用的推动装置的结构示意图；
图46为导向部件采用推杆的第四种预装式混药器上使用的推动装置的结构示意图。
附图中： 1 -加药筒； 2 -加药双针； 3 -导向套Ⅰ； 4 -旋转套； 5 -导向筒； 6 -导向套Ⅱ； 7 -导向螺旋槽； 8 -导向通槽； 9 -导向块； 10 -压环 ；11-密封圈； 12-环形胶垫； 13-吊环； 14-输液容器； 15-双针支撑座； 16-防滑扣； 17-药物容器； 18 -环形卡； 19-环形凹槽； 20-环形卡槽； 22 -接口； 23 -隔膜； 24 -卡接组件； 241-第一弧形卡； 242-第二弧形卡； 243-密封垫；244-倒扣； 25-接口连接端； 26-推杆； 27-导向螺旋通槽； 28-导向槽；29-通气孔 。
具体实施方式
下面结合附图和具体实施方式对本发明作进一步详细地描述。
第一种预装式混药器的结构，请参见图1至图14：
预装式混药器，包括旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向部件、加药筒1和加药双针2。
其中，加药筒1的结构如图2所示，加药筒1的底端为接口连接端25，接口连接端25的内壁为一缩口结构，这样更利于与输液容器14（即输液软袋或输液软瓶）的接口尺寸匹配。加药筒1的内壁、且靠近接口连接端25设有环形胶垫12，加药双针2（本实施例的加药双针2采用十字针，即加药双针2的上针、下针和双针支撑座15一体成型，且沿该加药双针的轴线的剖切面为"十字"结构）设在加药筒1内，加药双针2的下针尖穿过环形胶垫12并卡在环形胶垫12上，加药双针2的双针支撑座15位于环形胶垫12的上方，加药双针2的下针的长度大于上针的长度。在加药筒1的内壁上对称设置有至少两个呈倒钩状的防滑扣16（本实施例中，在加药筒1的内壁上对称设置有四个防滑扣），在药物容器17装入加药筒1内后，在药物容器17与输液容器14混药时（如图13所示），药物容器17的瓶盖被卡在防滑扣16的下方，该防滑扣16可有效地阻止药物容器17后退，保障混药顺利进行。
导向套Ⅱ6的结构如图3所示，导向套Ⅱ6的底端与加药筒1的顶端密封对接（可采用焊合的方式连接），导向套Ⅱ6的内壁设置导向螺旋槽7，本实施例中，导向套Ⅱ6的内壁上对称设置两条导向螺旋槽7。在导向套Ⅱ6的内壁顶部沿周向设有环形卡18，在导向套Ⅱ6的顶端面上沿圆周方向设有环形凹槽19。
导向套Ⅱ6与加药筒1可一体成型，如图4所示。
导向套Ⅰ3和旋转套4的结构如图5和图6所示，在本实施例中，导向套Ⅰ3和旋转套4一体成型。导向套Ⅰ3伸入导向套Ⅱ6内，导向套Ⅰ3的顶端与旋转套4的底端连接（采用焊合的方式对接），旋转套4与导向套Ⅱ6形成轴向固定、径向可转动配合，且旋转套4与导向套Ⅱ6密封配合，旋转套4的顶端为密封端。本实施例中，在旋转套4的外壁沿周向设有压环10，在压环10的下方沿周向设有环形卡槽20。当旋转套4安装在导向套Ⅱ6上后，环形卡18位于环形卡槽20内，在环形凹槽19内安装有密封圈11，压环10通过密封圈11压在导向套Ⅱ6的顶端上并与其密封配合。在转动旋转套4时，环形卡18在环形卡槽20内转动，因密封圈11的密封作用，使旋转套4在导向套Ⅱ6上既可转动，又能实现旋转套4的外壁与导向套Ⅱ6的顶部密封。导向套Ⅰ3的侧壁上沿轴向设有导向通槽8（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向通槽8）。导向通槽8的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，形成"z"字形的导向通槽8，导向通槽8的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。在药物容器17与输液容器14进行混药之前（如图12所示），导向部件上的导向块9位于导向通槽8顶端圆周方向的槽内，有效地阻止了导向部件沿轴向从下移动，从而避免了导向部件在混药之前推动药物容器17下移；在药物容器17与输液容器14混药时（如图13、14所示），导向部件上的导向块9位于导向通槽8底端圆周方向的槽内，有效地阻止了导向部件沿轴向从上移动，从而有效地阻止药物容器17后退，进一步保障混药顺利进行。
导向部件为平板、抓斗、导向筒5或推杆26。导向部件采用平板时，在平板的两侧设置导向块9，使用该加药器时只需将药物容器17直接放置在导向套Ⅰ3内并位于平板的下方，通过平板的两侧设置的导向块实现向下导向移动，平板与药物容器17接触并可直接推动药物容器17向下移动。
导向部件采用抓斗时，抓斗的开口向下并与加药双针2对应，在抓斗的两侧的外壁上对称设置的导向块9，使用该加药器时药物容器17需预先放置在抓斗内，抓斗抓紧药物容器17，通过抓斗两侧外壁上设置的导向块实现向下导向移动，抓斗可直接推动药物容器17下移。
导向部件采用导向筒5，导向筒5的一端敞口，导向筒5的敞口端与加药双针2对应，导向筒5的内腔为药物容器容置腔，在导向筒5的外壁上对称设有两个导向块9（如图7、8所示）。使用该加药器时药物容器17需预先放置在导向筒5内，导向筒5的内壁有效地限制药物容器17在使用过程中左右晃动，通过导向筒5可直接推动药物容器17下移。
导向部件也可采用推杆26，推杆26的结构如图9和图10所示，推杆26沿旋转套4的轴向设置在旋转套4内，推杆26为上端开口、下端密封的中空结构，且推杆26形成上部内孔直径大、下部内孔直径小的中空结构。在上部内孔的底部壁上均布有沿轴向设置的通气孔29，在推杆26向下移动过程时，该通气孔29有利于下部空间内的气体流向上部空间，降低推杆26下移的空气阻力。在推杆26的外壁上对称设有两个导向块9，其中一个导向块9穿过一导向通槽8并伸入一导向螺旋槽7内，另一个导向块9穿过另一导向通槽8并伸入另一导向螺旋槽7内。推杆26沿旋转套4的轴线设置在旋转套4内，加药双针2的上针尖与推杆26对应，在药物容器17放置在加药筒1内后，推杆26的底部与药物容器17的顶部正中对应，加药双针2的上针尖与药物容器17的瓶盖对应。
接口连接端25的底部设有用于将输液容器14的接口和接口连接端25连接的卡接组件24（如图11～14所示）。卡接组件24为环形卡，环形卡包括第一弧形卡241和第二弧形卡242，第一弧形卡241和第二弧形卡242的横截面均为内凹结构，在第一弧形卡241和第二弧形卡242的内凹槽内均设置密封垫243。第一弧形卡241的一端和第二弧形卡242的一端铰接，第一弧形卡241的另一端和第二弧形卡242的另一端卡接。本实施例中，第一弧形卡241的另一端和第二弧形卡242的另一端搭接后扣合连接，即在第一弧形卡241的另一端和第二弧形卡242的另一端的相对内侧设置倒扣244，第一弧形卡241的另一端和第二弧形卡242的另一端通过其上的倒扣244相互扣合连接（如图11所示）。将加药筒1的接口连接端25与输液容器14上的接口22连接时，首先将接口连接端25底部的环形凸台与接口22上的环形凸台贴在一起，再将环形卡扣24上的第一弧形卡241和第二弧形卡242卡在接口连接端25底部的环形凸台与接口22上的环形凸台上，第一弧形卡241和第二弧形卡242通过其上的倒扣244相互扣合连接，加药筒1的接口连接端25与输液容器14上的接口22便通过环形卡扣24内的密封垫243实现密封连接。
在旋转套4的密封端上（即旋转套4的顶部）设有一吊环13，通过该吊环13可将该加药器以及与加药器连接的输液容器14（如图12～14所示）一起悬挂在输液所用的支撑架上。
使用第一种预装式混药器时，先将加药筒1的底端与输液容器14上的接口22通过卡接组件24密封连接（也可采用焊合的方式和用螺纹连接的方式实现密封连接），本实施例中，输液容器14采用输液软袋，如图12所示，将药物容器17在无菌条件下预装入加药筒1内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动推杆26沿导向套Ⅱ6内壁上的导向螺旋槽7迅速下移，直接施压在药物容器17上，进而推动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图13所示，整个过程均处于无菌对接，且整个过程均通过转动旋转套4驱动推杆26向下移动实现。而推杆26下移需依靠旋转套4转动才能实现，所以可以防止在运输和储存中，推杆26压迫药物容器17。推杆26上的导向块9下移到导向通槽8的底端圆周方向的槽内时，药物容器17被推动到瓶盖位于防滑扣16的下方，有效地阻止药物容器17后退，保障混药顺利进行。由于该预装式混药器自预装入药物容器后直至输液完成，所涉及的药物容器和与药物直接接触的部件均处于无菌状态，因此，可实现药品在运输、储存、对接、混药及输液的全过程无菌密闭。在混药之前和混药时，药物容器17均处在加药筒1内，因加药筒1由透明材料制成，操作人员只需通过透明的加药筒1便可观察药物容器17上的所配药物的信息，有利于操作者及时掌握所配的药物信息，避免药物错配。
加药筒1也可采用图8和图14所示的混药卡体的结构，导向部件采用导向筒5，使用时需先将药物容器17在无菌条件下预装入导向筒5内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动导向筒5沿导向套Ⅱ6内壁上的导向螺旋槽7迅速下移，进而带动导向筒5内的药物容器17下移，药物容器17施压在加药双针2上并驱动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图14所示。将药物容器17预装入导向筒5内，混药时大大缩短了导向筒5和药物容器17下移距离（即实现短进程混药）。
第一种预装式混药器上使用的推动装置的结构，请参见图15～16：
预装式混药器上使用的推动装置包括旋转套4、导向套Ⅰ3、导向套Ⅱ6和导向部件。导向套Ⅰ3伸入导向套Ⅱ6内，导向套Ⅰ3的顶端与旋转套4的底端连接（采用焊合的方式对接），旋转套4的顶端密封，本实施例中，旋转套与导向套Ⅰ3一体成型。导向套Ⅰ3的侧壁上沿轴向设有导向通槽8，导向通槽8的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，导向通槽8的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致；导向套Ⅱ6的内壁设置导向螺旋槽。导向部件设在导向套Ⅰ3内，导向部件的外侧具有导向块9，导向块9穿过导向通槽8并伸进导向螺旋槽7内，使旋转套4与导向套Ⅱ6形成轴向固定、径向可转动配合。
导向部件为平板、抓斗、导向筒或推杆。旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向筒5和推杆26的结构与第一种预装式混药器中的结构相同，在此不再赘述。
组装该预装式混药器上使用的推动装置时，首先将导向部件（导向部件采用导向筒5时，如图15所示；导向部件采用推杆26时，如图16所示）装入导向套Ⅰ3内，导向部件上的导向块9穿过导向套Ⅰ3上的导向通槽8，并将导向部件推到导向套Ⅰ3和旋转套7的连接端；然后将导向套Ⅱ6套在导向套Ⅰ3上，使导向部件上的导向块9插入导向套Ⅱ6上的导向螺旋槽7内，并将旋转套4扣合在导向套Ⅱ6的顶部。
第一种预装式混药器上使用的推动装置与加药筒和加药双针组装后进行混药的方式与第一种预装式混药器进行混药的方式相同，在此不再赘述。
第二种预装式混药器的结构，请参见图17至图24：
预装式混药器包括旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向部件、加药筒1和加药双针2。
其中加药筒1和加药双针2在加药筒1中的结构与第一种预装式混药器中的结构相同，在此不再赘述。
导向套Ⅱ6和旋转套4的结构如图18和图19所示，在本实施例中，导向套Ⅱ6和旋转套4一体成型，旋转套4的顶端密封。导向套Ⅱ6的内壁设置导向螺旋槽7，本实施例中，导向套Ⅱ6的内壁上对称设置两条导向螺旋槽7。在旋转套4的内壁上沿周向设有压环10，在压环10的下方沿周向设有环形卡槽20。
导向套Ⅰ3的结构如图20所示，导向套Ⅰ3的底端与加药筒1的顶端密封对接（可采用焊合的方式连接），导向套Ⅰ3伸入导向套Ⅱ6内，在导向套Ⅰ3的外壁顶部沿周向设有环形卡18，在导向套Ⅰ3的顶端面上沿圆周方向设有环形凹槽19。当旋转套4安装在导向套Ⅰ3上后，环形卡18位于环形卡槽20内，在环形凹槽19内安装有密封圈11，压环10通过密封圈11压在导向套Ⅰ3上并与其密封配合。在转动旋转套4时，环形卡18在环形卡槽20内转动，因密封圈11的密封作用，使旋转套4在导向套Ⅰ3上即可转动，又能实现旋转套4的内壁与导向套Ⅰ3的顶部密封。导向套Ⅰ3的侧壁上沿轴向设有导向通槽8（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向通槽8）。导向通槽8的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，形成"z"字形的导向通槽8，导向通槽8的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。在药物容器17与输液容器14进行混药之前（如图22所示），导向部件上的导向块9位于导向通槽8顶端圆周方向的槽内，有效地阻止了导向部件沿轴向从下移动，从而避免了导向部件在混药之前推动药物容器17下移；在药物容器17与输液容器14混药时（如图23、24所示），导向部件上的导向块9位于导向通槽8底端圆周方向的槽内，有效地阻止了导向部件沿轴向从上移动，从而有效地阻止药物容器17后退，进一步保障混药顺利进行。
导向套Ⅰ3与加药筒1可一体成型，如图21所示。
导向部件为平板、抓斗、导向筒或推杆。导向筒5和推杆26的结构与第一种预装式混药器中的结构相同，平板、抓斗、导向筒或推杆的安装位置和工作原理均与在第一种预装式混药器中的安装位置和工作原理相同，在此不再赘述。在加药筒1的底部同样也设置有卡接组件24，在旋转套4的顶部设有吊环13。
使用导向部件采用推杆的第二种预装式混药器时，先将加药筒1的底端与输液容器14上的接口22通过卡接组件24密封连接，如图22所示，将药物容器17在无菌条件下预装入加药筒1内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动推杆26沿导向套Ⅰ3上的导向通槽8迅速下移，直接施压在药物容器17上，进而推动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图23所示 。 推杆26上的导向块9下移到导向通槽8的底端圆周方向的槽内时，药物容器17被推动到瓶盖位于防滑扣16的下方，有效地阻止药物容器17后退，保障混药顺利进行 。由于该 预装式混药器自预装入药物容器后直至输液完成，所涉及的药物容器和与药物直接接触的部件均处于无菌状态， 因此， 可实现药品在运输、储存、对接、混药及输液的 全过程无菌密闭 。在混药之前和混药时，药物容器17均处在加药筒1内，因加药筒1由透明材料制成，操作人员只需通过透明的加药筒1便可观察药物容器17上的所配药物的信息，有利于操作者及时掌握所配的药物信息，避免药物错配。
加药筒1也可采用图24所示的混药卡体的结构，导向部件采用导向筒5，使用时需先将药物容器17在无菌条件下预装入导向筒5内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动导向筒5沿导向套Ⅰ3上的导向通槽8迅速下移，进而带动导向筒5内的药物容器17下移，药物容器17施压在加药双针2上并驱动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图24所示。将药物容器17预装入导向筒5内，混药时大大缩短了导向筒5和药物容器17下移距离（即实现短进程混药）。
第二种预装式混药器上使用的推动装置的结构，请参见图25和图26：
第二种预装式混药器上使用的推动装置包括旋转套4、导向套Ⅰ3、导向套Ⅱ6和导向部件。导向套Ⅰ3伸入导向套Ⅱ6内，导向套Ⅰ3的侧壁上沿轴向设有导向通槽8（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向通槽8），导向通槽8的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，导向通槽8的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。旋转套4的顶端密封，旋转套4的底端与导向套Ⅱ6的顶端连接（采用焊接的方式对接），在本实施例中，导向套Ⅱ6和旋转套4一体成型。导向部件设在导向套Ⅰ3内，导向部件的外侧具有导向块9，导向块9穿过导向通槽8并伸进导向螺旋槽7内，使旋转套4与导向套Ⅰ3形成轴向固定、径向可转动配合。
导向部件为平板、抓斗、导向筒或推杆。旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向筒5和推杆26的结构与第二种预装式混药器中的结构相同，在此不再赘述。
组装该预装式混药器上使用的推动装置时，首先将导向部件（导向部件采用导向筒5时，如图25所示；导向部件采用推杆26时，如图26所示）装入导向套Ⅱ6内，导向部件上的导向块9插入导向套Ⅱ6上的导向螺旋槽7内，并将导向部件推到导向套Ⅱ6与旋转套4的连接端；然后将导向套Ⅰ3插入导向套Ⅱ6内，使导向部件上的导向块9穿过导向套Ⅰ3上的导向通槽8内，并将旋转套4扣合在导向套Ⅰ3的顶部。
第二种预装式混药器上使用的推动装置与加药筒和加药双针组装后进行混药的方式与第二种预装式混药器进行混药的方式相同，在此不再赘述。
第三种预装式混药器的结构，请参见图27～34：
第三种预装式混药器包括旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向部件、加药筒1和加药双针2。
其中，加药筒1和加药双针2在加药筒1中的结构与第一种预装式混药器中的结构相同，在此不再赘述。
导向套Ⅰ3和旋转套4的结构如图28和图29所示，导向套Ⅰ3的顶端与旋转套4的底端连接（可采用焊合的方式对接），旋转套4的顶端密封。在本实施例中，导向套Ⅰ3和旋转套4一体成型。在旋转套4的内壁上沿圆周方向设有压环10，在压环10的下方沿周向设有环形卡槽20。导向套Ⅰ3的侧壁上沿轴向设有导向槽28（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿周向设置的导向槽28）。导向槽28的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，导向槽28的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。在药物容器17与输液容器进行混药之前（如图32所示），导向部件上的导向块9位于导向槽28顶端圆周方向的槽内，有效地阻止了导向部件沿轴向从下移动，从而避免了导向部件在混药之前推动药物容器17下移；在药物容器17与输液容器14混药时（如图33、34所示），导向部件上的导向块9位于导向槽28底端圆周方向的槽内，有效地阻止了导向部件沿轴向从上移动，从而有效地阻止药物容器17后退，进一步保障混药顺利进行。
导向套Ⅱ6的结构如图30所示，导向套Ⅱ6伸入导向套Ⅰ3内，导向套Ⅱ6的内壁设置导向螺旋通槽27，本实施例中，导向套Ⅱ6的内壁上对称设置两条导向螺旋通槽27。导向套Ⅱ6的底端与加药筒1的顶端密封对接（可采用焊合的方式对接），在导向套Ⅱ6的外壁顶部沿周向设有环形卡18，在导向套Ⅱ6的顶端面上沿圆周方向设有环形凹槽19。当旋转套4安装在导向套Ⅱ6上后，环形卡18位于环形卡槽20内，在环形凹槽19内安装有密封圈11，压环10通过密封圈11压在导向套Ⅱ6上并与其密封配合。在转动旋转套4时，环形卡18在环形卡槽20内转动，因密封圈11的密封作用，使旋转套4在导向套Ⅱ6上即可转动，又能实现旋转套4的内壁与导向套Ⅱ6的顶部密封。
导向套Ⅱ6和加药筒1可一体成型，如图31所示。
导向部件设在导向套Ⅱ6内，导向部件的外侧具有导向块9，导向块9穿过导向螺旋通槽27并伸进导向槽28内，使旋转套4与导向套Ⅱ6形成轴向固定、径向可转动配合。导向部件为平板、抓斗、导向筒或推杆。导向筒5和推杆26的结构与第一种预装式混药器中的结构相同，平板、抓斗、导向筒或推杆的安装位置和工作原理均与在第一种预装式混药器中的安装位置和工作原理相同，在此不再赘述。在加药筒1的底部同样也设置有卡接组件24，在旋转套4的顶部设有吊环13。
使用导向部件采用推杆的第三种预装式混药器时，先将加药筒1的底端与输液容器14上的接口22通过卡接组件24密封连接，如图32所示，将药物容器17在无菌条件下预装入加药筒1内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动推杆26沿导向套Ⅱ6内壁上的导向螺旋通槽27迅速下移，直接施压在药物容器17上，进而推动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图33所示 。 推杆26上的导向块9下移到导向槽28的底端圆周方向的槽内时，药物容器17被推动到瓶盖位于防滑扣16的下方，有效地阻止药物容器17后退，保障混药顺利进行 。由于该 预装式混药器自预装入药物容器后直至输液完成，所涉及的药物容器和与药物直接接触的部件均处于无菌状态， 因此， 可实现药品在运输、储存、对接、混药及输液的 全过程无菌密闭 。在混药之前和混药时，药物容器17均处在加药筒1内，因加药筒1由透明材料制成，操作人员只需通过透明的加药筒1便可观察药物容器17上的所配药物的信息，有利于操作者及时掌握所配的药物信息，避免药物错配。
加药筒1也可采用图34所示的混药卡体的结构，导向部件采用导向筒5，使用时需先将药物容器17在无菌条件下预装入导向筒5内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动导向筒5沿导向套Ⅱ6内壁上的导向螺旋通槽27迅速下移，进而带动导向筒5内的药物容器17下移，药物容器17施压在加药双针2上并驱动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图34所示。将药物容器17预装入导向筒5内，混药时大大缩短了导向筒5和药物容器17下移距离（即实现短进程混药）。
第三种预装式混药器上使用的推动装置的结构，请参见图35和图36：
第三种预装式混药器上使用的推动装置包括旋转套4、导向套Ⅰ3、导向套Ⅱ6和导向部件。导向套Ⅱ6伸入导向套Ⅰ3内，导向套Ⅱ6的内壁设置导向螺旋通槽27（本实施例中，导向套Ⅱ6的内壁对称设置两条导向螺旋通槽27）。导向套Ⅰ3的顶端与旋转套4的底端连接（采用焊合的方式对接），本实施例中，导向套Ⅰ3和旋转套4一体成型。导向套Ⅰ3的侧壁上沿轴向设有导向槽28（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向槽28），导向槽28的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，导向槽28的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。导向部件设在导向套Ⅱ6内，导向部件的外侧具有导向块9，导向块9穿过导向螺旋通槽27并伸进导向槽28内，使旋转套4与导向套Ⅱ6形成轴向固定、径向可转动配合。
组装该预装式混药器上使用的推动装置时，首先将导向部件（导向部件采用导向筒5时，如图35所示；导向部件采用推杆26时，如图36所示）装入导向套Ⅰ3内，导向部件上的导向块9插入导向套Ⅰ3上的导向槽28内，并将导向部件推到导向套Ⅰ3与旋转套4的连接端；然后将导向套Ⅱ6插入导向套Ⅰ3内，使导向部件上的导向块9穿过导向套Ⅱ6上的导向螺旋通槽27，并将旋转套4扣合在导向套Ⅱ6的顶部。
第三种预装式混药器上使用的推动装置与加药筒和加药双针组装后进行混药的方式与第三种预装式混药器进行混药的方式相同，在此不再赘述。
第四种预装式混药器的结构，请参见图37～44：
预装式混药器包括旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向部件、加药筒1和加药双针2。
其中，加药筒1和加药双针2在加药筒1中的结构与第一种预装式混药器中的结构相同，在此不再赘述。
导向套Ⅱ6和旋转套4的结构如图38和39所示，导向套Ⅱ6的顶端与旋转套4的底端连接（可采用焊合的方式对接）。在本实施例中，导向套Ⅱ6和旋转套4一体成型，旋转套4的顶端密封。导向套Ⅱ6的内壁设置导向螺旋通槽27，本实施例中，导向套Ⅱ6的内壁上对称设置两条导向螺旋通槽27。在旋转套4的外壁上沿圆周方向设有压环10，在压环10的下方沿圆周设有环形卡槽20。
导向套Ⅰ3的结构如图40所示，导向套Ⅰ3的底端与加药筒1的顶端密封对接（可采用焊合的方式连接），导向套Ⅱ6伸入导向套Ⅰ3内，在导向套Ⅰ3的内壁顶部沿周向设有环形卡18，在导向套Ⅰ3的顶端面上沿圆周方向设有环形凹槽19。当旋转套4安装在导向套Ⅰ3上后，环形卡18位于环形卡槽20内，在环形凹槽19内安装有密封圈11，压环10通过密封圈11压在导向套Ⅰ3上并与其密封配合。在转动旋转套4时，环形卡18在环形卡槽20内转动，因密封圈11的密封作用，使旋转套4在导向套Ⅰ3上即可转动，又能实现旋转套4的外壁与导向套Ⅰ3的顶部密封。导向套Ⅰ3的侧壁上沿轴向设有导向槽28（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向槽28）。导向槽28的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，形成"z"字形的导向槽28，导向槽28的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。在药物容器17与输液容器14进行混药之前（如图42所示），导向部件上的导向块9位于导向槽28顶端圆周方向的槽内，有效地阻止了导向部件沿轴向从下移动，从而避免了导向部件在混药之前推动药物容器17下移；在药物容器17与输液容器14混药时（如图43、44所示），导向部件上的导向块9位于导向槽28底端圆周方向的槽内，有效地阻止了导向部件沿轴向从上移动，从而有效地阻止药物容器17后退，进一步保障混药顺利进行。
导向套Ⅰ3与加药筒1可一体成型，如图41所示。
导向部件设在导向套Ⅱ6内，导向部件的外侧具有导向块9，导向块9穿过导向螺旋通槽27并伸进导向槽28内，使旋转套4与导向套Ⅰ3形成轴向固定、径向可转动配合。导向部件为平板、抓斗、导向筒或推杆。导向筒5和推杆26的结构与第一种预装式混药器中的结构相同，平板、抓斗、导向筒或推杆的安装位置和工作原理均与在第一种预装式混药器中的安装位置和工作原理相同，在此不再赘述。在加药筒1的底部同样也设置有卡接组件24，在旋转套4的顶部设有吊环13。
使用导向部件采用推杆的第四种预装式混药器时，先将加药筒1的底端与输液容器14上的接口22通过卡接组件24密封连接，如图42所示，将药物容器17在无菌条件下预装入加药筒1内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动推杆26沿导向套Ⅰ3内壁上的导向槽28迅速下移，直接施压在药物容器17上，进而推动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图43所示 。 推杆26上的导向块9下移到导向槽28的底端圆周方向的槽内时，药物容器17被推动到瓶盖位于防滑扣16的下方，有效地阻止药物容器17后退，保障混药顺利进行 。由于该 预装式混药器自预装入药物容器后直至输液完成，所涉及的药物容器和与药物直接接触的部件均处于无菌状态， 因此， 可实现药品在运输、储存、对接、混药及输液的 全过程无菌密闭 。在混药之前和混药时，药物容器17均处在加药筒1内，因加药筒1由透明材料制成，操作人员只需通过透明的加药筒1便可观察药物容器17上的所配药物的信息，有利于操作者及时掌握所配的药物信息，避免药物错配。
加药筒1也可采用图44所示的混药卡体的结构，导向部件采用导向筒5，使用时需先将药物容器17在无菌条件下预装入导向筒5内，通过接口22内的隔膜23和顶端密封的旋转套4使药物容器17和加药双针2处于密封状态，因此，可达到运输和储存绝对的无菌。混药时，转动旋转套4，旋转套4驱动导向筒5沿导向套Ⅰ3内壁上的导向槽28迅速下移，进而带动导向筒5内的药物容器17下移，药物容器17施压在加药双针2上并驱动加药双针2下移，加药双针2的上针尖刺穿药物容器17上的密封塞，加药双针2的下针尖刺破接口22内的隔膜23，使药物容器17与输液软袋内瞬间连通，如图44所示。将药物容器17预装入导向筒5内，混药时大大缩短了导向筒5和药物容器17下移距离（即实现短进程混药）。
第四种预装式混药器上使用的推动装置的结构，请参见图45和图46：
预装式混药器上使用的推动装置包括旋转套4、导向套Ⅰ3、导向套Ⅱ6和导向部件。导向套Ⅱ6的伸入导向套Ⅰ3内，导向套Ⅱ6的顶端与旋转套4的底端连接（采用焊合的方式对接）。导向套Ⅱ6的内壁设置导向螺旋通槽27（本实施例中，导向套Ⅱ6的内壁对称设置两条导向螺旋通槽27），本实施例中，导向套Ⅱ6和旋转套4一体成型。导向套Ⅰ3的侧壁上沿轴向设有导向槽28（本实施例中，导向套Ⅰ3的侧壁上对称设有两条沿轴向设置的导向槽28），导向槽28的两端在导向套Ⅰ3的圆周上向相反的方向延伸出一段距离，导向槽28的底端在导向套Ⅰ3的圆周上延伸的方向与推动药物容器时旋转套4的旋转方向一致。导向部件设在导向套Ⅱ6内，导向部件的外侧具有导向块9，导向块9穿过导向螺旋通槽27并伸进导向槽28内，使旋转套4与导向套Ⅰ3形成轴向固定、径向可转动配合。
导向部件为平板、抓斗、导向筒或推杆。旋转套4、导向套Ⅰ3、导向套Ⅱ6、导向筒5和推杆26的结构与第四种预装式混药器中的结构相同，在此不再赘述。
组装该预装式混药器上使用的推动装置时，首先将导向部件（导向部件采用导向筒5时，如图45所示；导向部件采用推杆26时，如图46所示）装入导向套Ⅱ6内，导向部件上的导向块9穿过导向套Ⅱ6上的导向螺旋通槽27，并将导向部件推到导向套Ⅱ6与旋转套4的连接端；然后将导向套Ⅰ3套在导向套Ⅱ6上，使导向部件上的导向块9插入导向套Ⅰ3上的导向槽28内，并将旋转套4扣合在导向套Ⅰ3的顶部。
第四种预装式混药器上使用的推动装置与加药筒和加药双针组装后进行混药的方式与第四种预装式混药器进行混药的方式相同，在此不再赘述。
最后说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的宗旨和范围，其均应涵盖在本发明的权利要求范围当中。

Claims (80)

  1. 预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，其特征在于：
    所述导向套Ⅰ的一端伸入导向套Ⅱ内，导向套Ⅰ的另一端与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
    所述加药筒的一端为接口连接端，另一端与导向套Ⅱ的一端连接；所述导向套Ⅱ的内壁设置导向螺旋槽；
    所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
  2. 根据权利要求1所述的预装式混药器，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口与加药双针对应；
    所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
  3. 根据权利要求1或2所述的预装式混药器，其特征在于：所述旋转套的另一端为密封端。
  4. 根据权利要求3所述的预装式混药器，其特征在于：所述旋转套与导向套Ⅰ一体成型。
  5. 根据权利要求3所述的预装式混药器，其特征在于：所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
  6. 根据权利要求5所述的预装式混药器，其特征在于：所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
  7. 根据权利要求3所述的预装式混药器，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
  8. 根据权利要求3所述的预装式混药器，其特征在于：所述加药筒与导向套Ⅱ一体成型。
  9. 根据权利要求3所述的预装式混药器，其特征在于：所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
  10. 根据权利要求3所述的预装式混药器，其特征在于：所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
  11. 根据权利要求3所述的预装式混药器，其特征在于：所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
  12. 根据权利要求11所述的预装式混药器，其特征在于：所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
  13. 根据权利要求3所述的预装式混药器，其特征在于：所述加药双针的下针的长度大于上针的长度。
  14. 预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，其特征在于：
    所述加药筒的一端为接口连接端，另一端与导向套Ⅰ的一端连接；
    所述导向套Ⅰ的另一端伸入导向套Ⅱ内，所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
    所述导向套Ⅱ的内壁设置导向螺旋槽，导向套Ⅱ与旋转套的一端连接；
    所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
  15. 根据权利要求14所述的预装式混药器，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口与加药双针对应；
    所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
  16. 根据权利要求14或15所述的预装式混药器，其特征在于：所述旋转套的另一端为密封端。
  17. 根据权利要求16所述的预装式混药器，其特征在于：所述旋转套与导向套Ⅱ一体成型。
  18. 根据权利要求16所述的预装式混药器，其特征在于：所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动、且密封配合。
  19. 根据权利要求18所述的预装式混药器，其特征在于：所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
  20. 根据权利要求16所述的预装式混药器，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
  21. 根据权利要求16所述的预装式混药器，其特征在于：所述加药筒与导向套Ⅰ一体成型。
  22. 根据权利要求16所述的预装式混药器，其特征在于：所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
  23. 根据权利要求16所述的预装式混药器，其特征在于：所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
  24. 根据权利要求16所述的预装式混药器，其特征在于：所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
  25. 根据权利要求24所述的预装式混药器，其特征在于：所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
  26. 根据权利要求16所述的预装式混药器，其特征在于：所述加药双针的下针的长度大于上针的长度。
  27. 预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，其特征在于：
    所述加药筒的一端为接口连接端，另一端与导向套Ⅱ的一端连接，所述导向套Ⅱ的内壁设置导向螺旋通槽；
    所述导向套Ⅱ的另一端伸入导向套Ⅰ内，导向套Ⅰ与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
    所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
  28. 根据权利要求27所述的预装式混药器，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口与加药双针对应；
    所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
  29. 根据权利要求27或28所述的预装式混药器，其特征在于：所述旋转套的另一端为密封端。
  30. 根据权利要求29所述的预装式混药器，其特征在于：所述旋转套与导向套Ⅰ一体成型。
  31. 根据权利要求29所述的预装式混药器，其特征在于：所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
  32. 根据权利要求31所述的预装式混药器，其特征在于：所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
  33. 根据权利要求29所述的预装式加混器，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
  34. 根据权利要求29所述的预装式混药器，其特征在于：所述加药筒与导向套Ⅱ一体成型。
  35. 根据权利要求29所述的预装式混药器，其特征在于：所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
  36. 根据权利要求29所述的预装式混药器，其特征在于：所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
  37. 根据权利要求29所述的预装式混药器，其特征在于：所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
  38. 根据权利要求37所述的预装式混药器，其特征在于：所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
  39. 根据权利要求29所述的预装式混药器，其特征在于：所述加药双针的下针的长度大于上针的长度。
  40. 预装式混药器，包括旋转套、导向套Ⅰ、导向套Ⅱ、导向部件、加药筒和加药双针；所述加药双针设在加药筒内，其特征在于：
    所述加药筒的一端为接口连接端，另一端与导向套Ⅰ的一端连接；
    所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；
    所述导向套Ⅱ的一端伸入导向套Ⅰ内，导向套Ⅱ的另一端与旋转套的一端连接；所述导向套Ⅱ的内壁设置导向螺旋通槽；
    所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
  41. 根据权利要求40所述的预装式混药器，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口与加药双针对应；
    所述导向筒的一端敞口，导向筒的敞口端与加药双针对应，导向筒的内腔为药物容器容置腔。
  42. 根据权利要求40或41所述的预装式混药器，其特征在于：所述旋转套的另一端为密封端。
  43. 根据权利要求42所述的预装式混药器，其特征在于：所述旋转套与导向套Ⅱ一体成型。
  44. 根据权利要求42所述的预装式混药器，其特征在于：所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动、且密封配合。
  45. 根据权利要求44所述的预装式混药器，其特征在于：所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
  46. 根据权利要求42所述的预装式混药器，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
  47. 根据权利要求42所述的预装式混药器，其特征在于：所述加药筒与导向套Ⅰ一体成型。
  48. 根据权利要求42所述的预装式混药器，其特征在于：所述加药筒的内壁上对称设置有至少两个呈倒钩状、且用于防止药物容器松动的防滑扣。
  49. 根据权利要求42所述的预装式混药器，其特征在于：所述加药筒的内壁上、且靠近接口连接端设置环形胶垫，所述加药双针与接口连接端对应的针尖穿过该环形胶垫。
  50. 根据权利要求42所述的预装式混药器，其特征在于：所述加药筒的底端设有用于将输液容器的接口和接口连接端连接的卡接组件。
  51. 根据权利要求50所述的预装式混药器，其特征在于：所述卡接组件为环形卡，所述环形卡包括第一弧形卡和第二弧形卡，所述第一弧形卡和第二弧形卡的内壁均设置密封垫；所述第一弧形卡的一端和第二弧形卡的一端铰接，第一弧形卡的另一端和第二弧形卡的另一端卡接。
  52. 根据权利要求42所述的预装式混药器，其特征在于：所述加药双针的下针的长度大于上针的长度。
  53. 预装式混药器上使用的推动装置，其特征在于：包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅰ的一端伸入导向套Ⅱ内，导向套Ⅰ的另一端与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向套Ⅱ的内壁设置导向螺旋槽；所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
  54. 根据权利要求53所述的预装式混药器上使用的推动装置，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口向下；
    所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
  55. 根据权利要求53或54所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的另一端为密封端。
  56. 根据权利要求55所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套与导向套Ⅰ一体成型。
  57. 根据权利要求55所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅱ的另一端上并与其转动、且密封配合。
  58. 根据权利要求57所述的预装式混药器上使用的推动装置，其特征在于：所述压环通过密封圈与导向套Ⅱ的另一端密封配合。
  59. 根据权利要求55所述的预装式混药器上使用的推动装置，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
  60. 预装式混药器上使用的推动装置，其特征在于：包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅰ的一端伸入导向套Ⅱ内，所述导向套Ⅰ的侧壁上沿轴向设有导向通槽，所述导向通槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向通槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向套Ⅱ的内壁设置导向螺旋槽，导向套Ⅱ与旋转套的一端连接；所述导向部件设在导向套Ⅰ内，导向部件的外侧具有导向块，所述导向块穿过导向通槽并伸进导向螺旋槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
  61. 根据权利要求60所述的预装式混药器上使用的推动装置，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口向下；
    所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
  62. 根据权利要求60或61所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的另一端为密封端。
  63. 根据权利要求62所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套与导向套Ⅱ一体成型。
  64. 根据权利要求62所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅰ的另一端上并与其转动、且密封配合。
  65. 根据权利要求64所述的预装式混药器上使用的推动装置，其特征在于：所述压环通过密封圈与导向套Ⅰ的另一端密封配合。
  66. 根据权利要求62所述的预装式混药器上使用的推动装置，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向通槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向通槽并伸入一导向螺旋槽内，另一个导向块穿过另一导向通槽并伸入另一导向螺旋槽内。
  67. 预装式混药器上使用的推动装置，其特征在于：包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅱ的一端伸入导向套Ⅰ内，所述导向套Ⅱ的内壁设置导向螺旋通槽；导向套Ⅰ与旋转套的一端连接；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅱ形成轴向固定、径向可转动配合。
  68. 根据权利要求67所述的预装式混药器上使用的推动装置，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口向下；
    所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
  69. 根据权利要求67或68所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的另一端为密封端。
  70. 根据权利要求69所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套与导向套Ⅰ一体成型。
  71. 根据权利要求69所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的内壁沿周向设有压环，所述压环压在导向套Ⅱ的一端上并与其转动、且密封配合。
  72. 根据权利要求69所述的预装式混药器上使用的推动装置，其特征在于：所述压环通过密封圈与导向套Ⅱ的一端密封配合。
  73. 根据权利要求69所述的预装式混药器上使用的推动装置，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
  74. 预装式混药器上使用的推动装置，其特征在于：包括旋转套、导向套Ⅰ、导向套Ⅱ和导向部件；所述导向套Ⅱ的一端伸入导向套Ⅰ内，导向套Ⅱ的另一端与旋转套的一端连接；所述导向套Ⅱ的内壁设置导向螺旋通槽；所述导向套Ⅰ的侧壁上沿轴向设有导向槽，所述导向槽的两端在导向套Ⅰ的圆周上向相反的方向延伸出一段距离，所述导向槽的底端在导向套Ⅰ的圆周上延伸的方向与推动药物容器时旋转套的旋转方向一致；所述导向部件设在导向套Ⅱ内，导向部件的外侧具有导向块，所述导向块穿过导向螺旋通槽并伸进导向槽内，使旋转套与导向套Ⅰ形成轴向固定、径向可转动配合。
  75. 根据权利要求74所述的预装式混药器上使用的推动装置，其特征在于：所述导向部件为平板、抓斗、导向筒或推杆；
    所述抓斗的开口向下；
    所述导向筒的一端敞口，导向筒的敞口端向下，导向筒的内腔为药物容器容置腔。
  76. 根据权利要求74或75所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的另一端为密封端。
  77. 根据权利要求76所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套与导向套Ⅱ一体成型。
  78. 根据权利要求76所述的预装式混药器上使用的推动装置，其特征在于：所述旋转套的外壁沿周向设有压环，所述压环压在导向套Ⅰ的一端上并与其转动、且密封配合。
  79. 根据权利要求76所述的预装式混药器上使用的推动装置，其特征在于：所述压环通过密封圈与导向套Ⅰ的一端密封配合。
  80. 根据权利要求76所述的预装式混药器上使用的推动装置，其特征在于：所述导向套Ⅱ的内壁上对称设置两条导向螺旋通槽，所述导向套Ⅰ的侧壁上对称设有两条沿轴向设置的导向槽，所述导向部件的外侧上对称设有两个导向块，其中一个导向块穿过一导向螺旋通槽并伸入一导向槽内，另一个导向块穿过另一导向螺旋通槽并伸入另一导向槽内。
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