WO2013144643A3 - Dispositif et système de biocapteur - Google Patents

Dispositif et système de biocapteur Download PDF

Info

Publication number
WO2013144643A3
WO2013144643A3 PCT/GB2013/050832 GB2013050832W WO2013144643A3 WO 2013144643 A3 WO2013144643 A3 WO 2013144643A3 GB 2013050832 W GB2013050832 W GB 2013050832W WO 2013144643 A3 WO2013144643 A3 WO 2013144643A3
Authority
WO
WIPO (PCT)
Prior art keywords
detected
biological sample
biosensor device
sample
proteins
Prior art date
Application number
PCT/GB2013/050832
Other languages
English (en)
Other versions
WO2013144643A2 (fr
Inventor
Panteleimon ATHANASIOU
Alpesh Patel
David Whitaker
Hua Bai
John Palmer-Felgate
Daniel COOMBER-ALFORD
Sam Reed
Jessica FISHER
Chad Schneider
Alex Flamm
Ben Lane
Original Assignee
Dna Electronics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dna Electronics Ltd filed Critical Dna Electronics Ltd
Priority to JP2015502455A priority Critical patent/JP6141960B2/ja
Priority to US14/387,354 priority patent/US9739743B2/en
Priority to EP17210118.0A priority patent/EP3323511B1/fr
Priority to ES13717299.5T priority patent/ES2668475T3/es
Priority to EP13717299.5A priority patent/EP2830766B1/fr
Priority to CN201380017921.2A priority patent/CN104203411B/zh
Publication of WO2013144643A2 publication Critical patent/WO2013144643A2/fr
Publication of WO2013144643A3 publication Critical patent/WO2013144643A3/fr
Priority to US15/394,909 priority patent/US10527574B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4333—Mixers with scallop-shaped tubes or surfaces facing each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Electrochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Computer Hardware Design (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un système, un dispositif et un procédé de réception, préparation et identification d'un échantillon biologique. Certaines parties peuvent être tenues et actionnées par un utilisateur. L'échantillon peut être détecté par un réseau de capteurs. Le système peut comprendre des composants réutilisables et jetables, agencés de manière à se raccorder ensemble. L'échantillon biologique peut contenir des acides nucléiques, des protéines ou d'autres molécules à détecter.
PCT/GB2013/050832 2012-03-28 2013-03-28 Dispositif et système de biocapteur WO2013144643A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2015502455A JP6141960B2 (ja) 2012-03-28 2013-03-28 バイオセンサーのデバイス及びシステム
US14/387,354 US9739743B2 (en) 2012-03-28 2013-03-28 Biosensor device and system
EP17210118.0A EP3323511B1 (fr) 2012-03-28 2013-03-28 Dispositif de préparation d'échantillons biologiques
ES13717299.5T ES2668475T3 (es) 2012-03-28 2013-03-28 Dispositivo y sistema biosensor
EP13717299.5A EP2830766B1 (fr) 2012-03-28 2013-03-28 Dispositif et système de biocapteur
CN201380017921.2A CN104203411B (zh) 2012-03-28 2013-03-28 生物传感器装置和系统
US15/394,909 US10527574B2 (en) 2012-03-28 2016-12-30 Biosensor device and system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1205497.9 2012-03-28
GB1205497.9A GB2500658A (en) 2012-03-28 2012-03-28 Biosensor device and system

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/387,354 A-371-Of-International US9739743B2 (en) 2012-03-28 2013-03-28 Biosensor device and system
US15/394,909 Continuation US10527574B2 (en) 2012-03-28 2016-12-30 Biosensor device and system

Publications (2)

Publication Number Publication Date
WO2013144643A2 WO2013144643A2 (fr) 2013-10-03
WO2013144643A3 true WO2013144643A3 (fr) 2014-02-27

Family

ID=46087295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2013/050832 WO2013144643A2 (fr) 2012-03-28 2013-03-28 Dispositif et système de biocapteur

Country Status (7)

Country Link
US (2) US9739743B2 (fr)
EP (2) EP2830766B1 (fr)
JP (2) JP6141960B2 (fr)
CN (1) CN106501327B (fr)
ES (2) ES2668475T3 (fr)
GB (2) GB2500658A (fr)
WO (1) WO2013144643A2 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9789483B2 (en) 2013-03-11 2017-10-17 Cue Inc. System for portable and easy-to-use detection of analytes with mobile computing device
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
AU2014317986A1 (en) * 2013-09-06 2016-03-03 Theranos Ip Company, Llc Devices, systems, methods and kits for receiving a swab
US10058821B2 (en) * 2013-09-13 2018-08-28 Infineon Technologies Ag Ion pump
GB2519577A (en) * 2013-10-25 2015-04-29 Gene Onyx Ltd A genetic test control apparatus
PT3594360T (pt) 2014-04-24 2021-08-19 Lucira Health Inc Deteção colorimétrica da amplificação do ácido nucleico
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
AU2015302059B2 (en) * 2014-08-12 2020-02-06 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
BR112017021460A2 (pt) 2015-04-08 2018-07-03 Becton Dickinson Co método e aparelhagem para coleta de crescimento microbiológico a partir de uma superfície semi-sólida
AU2016296589B2 (en) 2015-07-17 2021-11-18 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US11260392B2 (en) * 2015-07-24 2022-03-01 Novel Microdevices, Inc. Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion and methods of use thereof
US11291995B2 (en) 2016-03-14 2022-04-05 Lucira Health, Inc. Selectively vented biological assay devices and associated methods
CA3240706A1 (fr) 2016-03-14 2017-09-21 Pfizer Inc. Systemes et procedes pour effectuer des tests biologiques
EP3430372A4 (fr) 2016-03-14 2019-10-16 Lucira Health, Inc. Dispositifs et procédés de préparation et d'acheminement d'échantillon d'essai biologique
WO2017180909A1 (fr) 2016-04-13 2017-10-19 Nextgen Jane, Inc. Dispositifs, systèmes et procédés de collecte et de conservation d'échantillon
WO2018025856A1 (fr) * 2016-08-02 2018-02-08 学校法人武庫川学院 Procédé de dépistage génétique simple, procédé de mesure du nombre de copies, et technologie de support associée
EP3519093B1 (fr) * 2016-09-30 2021-03-10 Koninklijke Philips N.V. Système d'application d'un réactif sur un échantillon
WO2018060421A1 (fr) * 2016-09-30 2018-04-05 Koninklijke Philips N.V. Système pour préparer un échantillon
EP3519094B1 (fr) * 2016-09-30 2020-06-24 Koninklijke Philips N.V. Système de préparation d'un échantillon
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US11666906B2 (en) * 2017-06-30 2023-06-06 Hewlett-Packard Development Company, L.P. Parts for diagnostic devices
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
CN209400538U (zh) 2017-09-21 2019-09-17 贝克顿·迪金森公司 引导从表面收集有害污染物样品的模板和包括其的系统
CN209624606U (zh) * 2017-09-21 2019-11-12 贝克顿·迪金森公司 危险污染检测系统
US11583861B2 (en) 2017-10-30 2023-02-21 Hewlett-Packard Development Company, L.P. Microfluidic devices
US11446663B2 (en) * 2018-01-26 2022-09-20 Aincobio Llc Method and apparatus for isolating and detecting biological and other particles
WO2020039960A1 (fr) * 2018-08-23 2020-02-27 Dic株式会社 Film d'étanchéité, film stratifié, et matériau d'emballage
CN108828238A (zh) * 2018-08-30 2018-11-16 苏州仁端生物医药科技有限公司 一种Aβ1-42检测试剂条及其应用
CN109142716A (zh) * 2018-08-30 2019-01-04 苏州仁端生物医药科技有限公司 一种联合检测Aβ-40和Aβ-42的检测试剂条及其应用
CN109212225A (zh) * 2018-08-30 2019-01-15 苏州仁端生物医药科技有限公司 一种磷酸化Tau蛋白检测试剂条及其应用
CN109001469A (zh) * 2018-08-30 2018-12-14 苏州仁端生物医药科技有限公司 一种Tau蛋白检测试剂条及其应用
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN109856201A (zh) * 2019-01-18 2019-06-07 深圳和而泰数据资源与云技术有限公司 唾液检测装置
KR20220012832A (ko) * 2019-01-24 2022-02-04 리머스 브릭스 앤더스 하웁트 유체 연동 레이어 펌프
US11280801B2 (en) 2019-01-28 2022-03-22 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
IL267301A (en) * 2019-06-12 2019-11-28 Gyntools Ltd A test device and hand-held sample collection tools for it
WO2021046506A1 (fr) * 2019-09-06 2021-03-11 Teleflex Medical Incorporated Systèmes et procédés de détection d'infection comprenant un filtrage et un mesurage intermédiaires
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
CN111558409B (zh) * 2020-06-10 2023-09-22 苏州点合医疗科技有限公司 一种安全存放式鼻咽拭子定位试管套件
CN111701498B (zh) * 2020-06-28 2022-04-19 南通理工学院 一种生产加工用机械式混料设备
JP2023005959A (ja) * 2021-06-30 2023-01-18 株式会社Ｓｃｒｅｅｎホールディングス 流路型デバイス
CN115251997B (zh) * 2022-06-17 2023-09-19 无锡市第五人民医院 一种新冠病毒鼻咽拭子的采样装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5839467A (en) * 1993-10-04 1998-11-24 Research International, Inc. Micromachined fluid handling devices
DE10238600A1 (de) * 2002-08-22 2004-03-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Peristaltische Mikropumpe
WO2004065010A2 (fr) * 2003-01-21 2004-08-05 Micronics Inc. Procede et systeme de manipulation microfluidique, amplification et analyse de fluides tels les essais de bacteries et tests antiglobuliniques

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3837534A (en) * 1972-10-16 1974-09-24 Rohe Scientific Corp Compact, flexible, multiple fluid dispenser
US4246339A (en) * 1978-11-01 1981-01-20 Millipore Corporation Test device
JPS5799188A (en) * 1980-12-12 1982-06-19 Nippon Tectron Co Ltd Culture cell device in measuring device for culture of microorganism
US4753536A (en) * 1987-03-09 1988-06-28 Spehar Edward R Dispensing mixer for the storage and mixing of separate materials
DE58907327D1 (de) 1988-06-01 1994-05-05 Deutsche Aerospace Vorrichtung mit Träger besonderer Struktur zur Aufnahme, Untersuchung und Behandlung von Proben.
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5413924A (en) * 1992-02-13 1995-05-09 Kosak; Kenneth M. Preparation of wax beads containing a reagent for release by heating
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
EP0572057A1 (fr) * 1992-05-11 1993-12-01 Johnson & Johnson Clinical Diagnostics, Inc. Composition et kit de réactifs de PCR et procédés pour amplification et détection avec amplification non-spécifique d'acides nucléiques réduite
GB9526653D0 (en) * 1995-12-29 1996-02-28 Shine Thomas A Fluid delivery device
DE19646505A1 (de) * 1996-11-12 1998-05-14 Itt Ind Gmbh Deutsche Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen
DE19920811B4 (de) 1999-05-06 2004-08-19 Micronas Gmbh Vorrichtung zur Durchführung von Untersuchungen an Zellkulturen
US7795012B2 (en) 1999-05-06 2010-09-14 Micronas Gmbh Device for performing analysis on cell cultures
NZ517565A (en) * 1999-08-05 2002-08-28 Bruce Harrison Trading As Sxy Direct aspiration-reaction and injection device and methods of use
US6656428B1 (en) * 1999-08-06 2003-12-02 Thermo Biostar, Inc. Automated point of care detection system including complete sample processing capabilities
EP1111281A1 (fr) * 1999-12-23 2001-06-27 Scitec Research SA Dispositif d'analyse comprenant une plaquette de petites dimensions à circulation de fluides
US6489172B1 (en) * 2000-01-05 2002-12-03 Varian, Inc. Saliva sampling device
AU2001265128A1 (en) * 2000-05-30 2001-12-11 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US7348183B2 (en) * 2000-10-16 2008-03-25 Board Of Trustees Of The University Of Arkansas Self-contained microelectrochemical bioassay platforms and methods
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
GB0110476D0 (en) * 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
AU2003215340A1 (en) * 2002-02-22 2003-09-09 Nanostream, Inc. Ratiometric dilution devices and methods
WO2003078621A1 (fr) * 2002-03-13 2003-09-25 Genomics Usa Inc. Procede de fabrication de microreseaux base sur l'immobilisation de susbtrats poreux sur des surfaces modifiables au plan thermique
WO2003087353A2 (fr) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. Nouveaux polypeptides purifies impliques dans la biogenese membranaire
AU2003204160B2 (en) * 2002-05-13 2010-05-13 Corning Incorporated Self-aliquoting sample storage plate system
AU2003232168A1 (en) * 2002-06-11 2003-12-22 Chempaq A/S Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells
US6730883B2 (en) * 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
CA2501640C (fr) * 2002-10-07 2007-07-24 Urschel Laboratories, Inc. Trancheuse alimentaire
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
EP1608952B1 (fr) * 2002-12-20 2016-08-10 Life Technologies Corporation Appareil et procede de dosage utilisant des reseaux microfluidiques
US20060014151A1 (en) * 2002-12-25 2006-01-19 Jun Ogura Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor
US20050010132A1 (en) * 2003-07-08 2005-01-13 Dale Pestes Swab having easily displaceable tip for collecting a saliva sample and inserting it into a collection device, and method of using same
NZ547174A (en) * 2003-11-14 2009-09-25 Inverness Medical Switzerland Rapid sample collection and analysis device and methods of use
US7749451B2 (en) * 2004-02-20 2010-07-06 Yale West Universal secure clamping apparatus
US7807043B2 (en) * 2004-02-23 2010-10-05 Oakville Hong Kong Company Limited Microfluidic test device
GB0414815D0 (en) * 2004-07-02 2004-08-04 Secr Defence Method for stabilising reagents which are useful for nucleic acid amplification
US7282181B2 (en) * 2004-09-16 2007-10-16 Varian Inc. Fluid collection and testing device
JP2006153788A (ja) * 2004-12-01 2006-06-15 Matsushita Electric Ind Co Ltd センサデバイスおよび分析装置
US20060216203A1 (en) * 2005-03-28 2006-09-28 Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. Multiwell sample plate with integrated impedance electrodes and connection scheme
FR2889461B1 (fr) * 2005-08-04 2007-10-26 Gilson Sas Soc Par Actions Sim Microtube de laboratoire.
JP5015441B2 (ja) * 2005-09-30 2012-08-29 凸版印刷株式会社 反応チップおよび反応方法
US20070105239A1 (en) * 2005-11-07 2007-05-10 The Regents Of The University Of California Method of forming vertical microelectrodes in a microchannel
US8871155B2 (en) * 2005-11-30 2014-10-28 Alere Switzerland Gmbh Devices for detecting analytes in fluid sample
US7879623B2 (en) * 2006-03-31 2011-02-01 Guirguis Raouf A Integrated device for analyte, testing, confirmation, and donor identity verification
WO2008065996A1 (fr) * 2006-11-28 2008-06-05 Shimadzu Corporation Plaque de réaction
US7851207B1 (en) * 2007-02-07 2010-12-14 The United States Of America As Represented By The Secretary Of The Army Multiplex field device to detect and identify a variety of microbial agents simultaneously
US7863035B2 (en) * 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
JP4893685B2 (ja) * 2007-07-26 2012-03-07 株式会社島津製作所 反応容器プレート及び反応処理方法
US8268634B2 (en) * 2007-11-29 2012-09-18 Ameditech, Inc. Fluid sample collecting and analyzing apparatus and method
DE102008042196A1 (de) * 2008-09-18 2010-03-25 Robert Bosch Gmbh Verfahren zum Herstellen eines mikrofluidischen Bauelementes sowie mikrofluidisches Bauelement
EP2169391B1 (fr) * 2008-09-30 2013-04-03 ibidi GmbH Dispositif de fixation d'une chambre d'analyse et système comprenant la chambre d'analyse et le dispositif de fixation
US8169006B2 (en) * 2008-11-29 2012-05-01 Electronics And Telecommunications Research Institute Bio-sensor chip for detecting target material
EP2233210A1 (fr) * 2009-03-23 2010-09-29 Aleria Biodevices, S. L. Dispositif pour la distribution séquentielle de réactifs liquides sur une chambre à réaction
GB0907605D0 (en) * 2009-05-01 2009-06-10 Univ Bristol Apparatus for testing the quality of a fluid sample
CN102782115A (zh) * 2009-07-20 2012-11-14 西罗亚生物科技有限公司 微流控分析平台
US20120028845A1 (en) * 2009-10-04 2012-02-02 Ross Teggatz Sensor for Detecting Biological Agents in Fluid
US20110244466A1 (en) * 2010-04-02 2011-10-06 Robert Juncosa Nucleic acid testing device and method
DE102010036216B4 (de) * 2010-08-29 2023-10-19 Microfluidic Chipshop Gmbh Vorrichtung zum Transfer von mittels Probennehmer gesammelter Proben in fluidische Plattformen
CN105842435B (zh) * 2010-12-03 2019-03-05 塞普莱有限公司 细胞功能的微分析
DE102011001550A1 (de) * 2011-03-25 2012-09-27 Friz Biochem Gesellschaft Für Bioanalytik Mbh Vorrichtung zum Fördern und Mischen von Mikromengen an Reagenzien und zur Durchführung chemischer Reaktionen
GB201212775D0 (en) * 2012-07-18 2012-08-29 Dna Electronics Ltd Sensing apparatus and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5839467A (en) * 1993-10-04 1998-11-24 Research International, Inc. Micromachined fluid handling devices
DE10238600A1 (de) * 2002-08-22 2004-03-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Peristaltische Mikropumpe
WO2004065010A2 (fr) * 2003-01-21 2004-08-05 Micronics Inc. Procede et systeme de manipulation microfluidique, amplification et analyse de fluides tels les essais de bacteries et tests antiglobuliniques

Also Published As

Publication number Publication date
US20170106371A1 (en) 2017-04-20
ES2668475T3 (es) 2018-05-18
GB201205497D0 (en) 2012-05-09
US20150076008A1 (en) 2015-03-19
GB2501179A (en) 2013-10-16
JP2017163993A (ja) 2017-09-21
EP3323511A1 (fr) 2018-05-23
EP3323511B1 (fr) 2021-10-27
EP2830766B1 (fr) 2018-02-21
GB201305651D0 (en) 2013-05-15
CN104203411A (zh) 2014-12-10
WO2013144643A2 (fr) 2013-10-03
GB2501179B (en) 2016-11-23
ES2905750T3 (es) 2022-04-12
GB2500658A (en) 2013-10-02
CN106501327B (zh) 2019-06-28
US10527574B2 (en) 2020-01-07
JP6448706B2 (ja) 2019-01-09
EP2830766A2 (fr) 2015-02-04
US9739743B2 (en) 2017-08-22
JP2015513102A (ja) 2015-04-30
CN106501327A (zh) 2017-03-15
JP6141960B2 (ja) 2017-06-07

Similar Documents

Publication Publication Date Title
WO2013144643A3 (fr) Dispositif et système de biocapteur
WO2013050881A3 (fr) Analyse directe d'acides nucléiques
WO2014011536A3 (fr) Dispositifs de collecte d'échantillons biologiques et procédés de production et d'utilisation associés
WO2011100708A3 (fr) Carte d'essai pour l'acquisition d'échantillon, traitement et réaction
WO2014107599A3 (fr) Compositions et procédés de détection d'une activité protéase dans des systèmes biologiques
SG11201500371VA (en) Methods of detecting dna, rna and protein in biological samples
EP3216852A4 (fr) Procédé d'introduction d'acide nucléique, procédé de détection d'acide nucléique, procédé d'analyse de constituant biologique, dispositif de réseau pour le dosage de constituant biologique, et kit pour l'analyse de constituant biologique
WO2014144713A3 (fr) Méthode de séquençage du répertoire immunitaire
EP3080585A4 (fr) Biocapteurs pour analyse biologique ou chimique et leurs méthodes de fabrication
EP2565260A4 (fr) Dispositif de purification automatique d'échantillon biologique à unité d'application de champ magnétique, procédé pour extraire une substance cible d'un échantillon biologique, et procédé d'expression et de purification de protéine
EP3201350A4 (fr) Procédé pour l'analyse d'acide nucléique directement à partir d'un échantillon biologique non purifié
WO2011143478A3 (fr) Identification d'acides nucléiques
WO2012122564A3 (fr) Dispositifs et méthodes de diagnostic et de préparation d'échantillons
WO2014052433A3 (fr) Procédé et système d'analyse d'une protéine et d'autres modifications sur l'adn et l'arn
EP2931921B8 (fr) Procédés sans marqueur pour l'isolement et l'analyse d'acides nucléiques sur dispositif en phase solide
EP2463660A4 (fr) Elément d'acide nucléique utilisable dans le cadre d'une analyse et procédé, réactif et instrument d'analyse l'utilisant
WO2011121454A3 (fr) Analyse directe des acides nucléiques
WO2012109574A3 (fr) Procédés de dosage à l'aide de protéines de liaison à l'adn
WO2014096973A3 (fr) Systèmes et procédés de détection interne d'analytes
MX2019003927A (es) Sistema de analisis y metodo para analizar una muestra.
MX2015012319A (es) Sistemas de instrumento analitico.
WO2015019195A3 (fr) Systèmes, dispositifs et procédés pour déployer des réactifs à bord d'un dispositif de diagnostic
EP3007824A4 (fr) Système et procédés de collecte d'échantillons de fluide préférentiels pour arn/protéines/adn
EP2482068A3 (fr) Préparation d'échantillons pour analyse de gaz utilisant un chauffage à induction
WO2013166444A3 (fr) Analyse de biomarqueurs utilisant la scodaphorèse

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13717299

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2013717299

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 14387354

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2015502455

Country of ref document: JP

Kind code of ref document: A