WO2013127244A1

WO2013127244A1 - Prepackaged reagent cuvette

Info

Publication number: WO2013127244A1
Application number: PCT/CN2012/087829
Authority: WO
Inventors: 何毅
Original assignee: He Yi
Priority date: 2012-02-28
Filing date: 2012-12-28
Publication date: 2013-09-06
Also published as: CN102590094A; CN102590094B

Abstract

A prepackaged reagent cuvette structure comprising a first reagent chamber having at the top part thereof an opening, a second reagent chamber having at both the top part and bottom part thereof openings, a sealing element, and a lid body. The sealing element interference fits the opening at the bottom part of the second reagent chamber; the sealing ring seals the opening at the bottom part of the second reagent chamber. The second reagent chamber is at the upper part inside the first reagent chamber; the outer wall of the second reagent chamber is sealedly connected to the inner wall of the first reagent chamber. The lid body is coveringly arranged on the opening at the top part of the second reagent chamber, while the inner sidewall of the lid body is sealedly connected to the outer wall of the first reagent chamber. An optical surface is provided on the side face and/or bottom face of the lower part of the first reagent chamber. When in use, testing is allowed by using the lid body to push away the sealing element.

Description

Reagent prepackaged cuvette

Technical field

The invention relates to the field of inspection and analysis instruments, and in particular to a cuvette structure.

Background technique

Conventional technical solutions at home and abroad, usually reagents are placed separately from the cuvettes, because the reagents need to be refrigerated to ensure that they are not degraded. They are usually stored in special reagent bottles and designed with special reagent refrigeration chambers. The cuvette can be a disposable plastic cup or a permanent glass. When working, use a special suction needle to suck out the refrigerating reagent, then spit it into the cuvette, react with the sample, and measure its change by optical system to determine its content or ingredient.

The shortcomings of the prior art are:

1. Separating reagents and cuvettes requires the user to have certain professional skills, know the principles and methods of operating the equipment, as well as the professional knowledge of calibration, quality control and parameter setting;

2. The operation process is complicated, and the test result has a long time period;

3. For fully automatic equipment, the split structure leads to increased costs, large size, complicated equipment and reduced reliability.

Summary of the invention

In order to overcome the deficiencies of the prior art, it is an object of the present invention to provide a reagent prepackaged cuvette that is capable of squeezing the process and reducing the threshold of the user's technology.

In order to achieve the above object, the technical solution adopted by the present invention is as follows:

A reagent pre-packaged cuvette comprising a first reagent cartridge having an opening at the top, a second reagent cartridge having an opening at the top and the bottom, a seal and a lid: a seal and an opening at the bottom of the second reagent cartridge An interference fit, and the seal is sealed with the opening at the bottom of the second reagent cartridge; the second reagent cartridge is mounted on the upper portion of the inner side of the first reagent cartridge, and the outer wall of the second reagent cartridge is sealingly connected to the inner wall of the first reagent cartridge; The cover is mounted on the opening of the top of the second reagent cartridge, and the inner side wall of the cover is sealingly connected with the outer wall of the first reagent cartridge; the side surface and/or the bottom surface of the lower portion of the first reagent cartridge is provided with an optical surface.

As a preferred structure, the outer wall of the second reagent chamber is provided with a sealing boss, and the sealing boss extends outward in the radial direction of the second reagent chamber, and the outer edge of the sealing boss and the inner wall of the first reagent chamber 4 Pick up. The number of the sealing bosses is three, and the three sealing bosses are arranged in order from the top to the bottom along the length direction of the second reagent cartridge. The longitudinal section of the sealing boss has a triangular shape.

As a preferred structure, the reagent pre-package cuvette further comprises a column; the inner side wall of the cover body is provided with a first-stage sealing flange, a second-stage sealing flange, a first-stage sealing flange, and a second-stage sealing convex The rim extends inward in the radial direction of the cover body, and the first-stage sealing flange is located below the second-stage sealing flange; the outer edge of the first-stage sealing flange abuts against the outer wall of the first reagent chamber, the second The outer edge of the stage sealing flange is placed on the top edge of the top of the first reagent cartridge; the fixed end of the column is fixedly connected to the top of the sealing member, and the column is located in the second reagent chamber and disposed along the length of the second reagent chamber; The inner top wall of the body extends downwardly with a lower pressing boss, the position of the lower pressing boss corresponds to the position of the column, and the bottom surface of the lower pressing boss is in contact with the top surface of the column; the second-stage sealing flange and the cover body The distance between the top walls is greater than or equal to the distance between the top of the seal and the bottom of the second reagent cartridge.

As a preferred structure, the reagent pre-package cuvette further comprises a column; the inner side wall of the cover body is provided with a first-stage sealing flange, a second-stage sealing flange, a first-stage sealing flange, and a second-stage sealing convex The rim extends inward in the radial direction of the cover body, and the first-stage sealing flange is located below the second-stage sealing flange; the outer edge of the first-stage sealing flange abuts against the outer wall of the first reagent chamber, the second The outer edge of the sealing flange is placed on the top edge of the top of the first reagent cartridge; the fixed end of the column is fixedly connected with the top of the sealing member, the free end of the column is in contact with the top wall of the lid body, and the column is located in the second reagent chamber And disposed along the length direction of the second reagent cartridge; The distance between the second stage sealing flange and the top wall of the cover is greater than or equal to the distance between the top of the seal and the bottom of the second reagent cartridge.

As a preferred construction, the inner top wall of the cover extends downwardly with a sealing projection that is sealingly coupled to the opening of the top of the second reagent chamber. The inner side wall of the cover body is provided with a sealing flange extending inward in the radial direction of the cover body, and the outer edge of the sealing flange is connected to the outer wall of the first reagent chamber.

As a preferred structure, the outer wall of the cover is connected to an anti-drop ring, and the anti-drop ring is sleeved on the outer wall of the upper portion of the first reagent cartridge.

As a preferred structure, the lower portion of the first reagent chamber is provided with an optical protection surface, and the optical protection surface is provided with a light transmission groove, and the position of the light transmission groove corresponds to the optical surface.

The invention has the following beneficial effects:

The R1 reagent and the R2 reagent are pre-packaged in the first reagent chamber and the second reagent chamber of the cuvette according to the parameters required for the test, and the corresponding information is prepared according to the ratio parameters of the R1 reagent and the R2 reagent. Barcode, and the barcode is attached to the outside of the cuvette. When using, the user can first read the calibration parameters previously determined by the manufacturer by scanning the barcode on the cuvette, and then only need to add the sample in the second reagent chamber. The test can be carried out by pushing the seal with a cover or a pipette to achieve the purpose of the user operation process and professional skills and the test speed. DRAWINGS

1 is a schematic perspective view of a reagent pre-packaged cuvette according to a first embodiment of the present invention;

2 is a schematic view showing a split structure of a reagent pre-packaged cuvette according to Embodiment 1 of the present invention;

3 is a schematic structural view showing a second reagent cartridge of a reagent pre-packaged cuvette and a sealing member according to a first embodiment of the present invention;

Figure 4 is a cross-sectional view taken along line AA of Figure 1; Figure 5 is an enlarged schematic view of the area A of Figure 4;

Figure 6 is an enlarged schematic view of the B area of Figure 4;

7 is a schematic perspective view showing the structure of a pre-packaged cuvette of a reagent according to a second embodiment of the present invention;

8 is a schematic view showing a split structure of a reagent pre-packaged cuvette according to a second embodiment of the present invention;

9 is a schematic structural view showing the connection of a second reagent cartridge of a reagent pre-packaged cuvette and a sealing member according to a second embodiment of the present invention;

Figure 10 is a cross-sectional view taken along line B-B of Figure 7;

Figure 11 is an enlarged schematic view of the C area of Figure 10;

Figure 12 is a cross-sectional view showing the structure of a reagent prepackaged cuvette according to a third embodiment of the present invention. detailed description

The present invention will be further described in conjunction with the drawings and specific embodiments in order to provide a better understanding of the technical concept claimed.

Embodiment 1

As shown in FIG. 1 to FIG. 6, a reagent pre-packaged cuvette includes a first reagent chamber 1 having an opening at the top, a second reagent chamber 2 having an opening at the top and the bottom, a seal 4, and a column. 401 and the cover 3.

The sealing member 4 has an interference fit with the opening at the bottom of the second reagent chamber 2, and the sealing member 4 is sealed with the opening at the bottom of the second reagent chamber 2, that is, a middle portion of the sealing member 4 may be provided with a protrusion, and a periphery of the protrusion is provided with a ridge. Or a plurality of elastic bumps, the sealing member 4 is plugged to the opening at the bottom of the second reagent chamber 2 like a plug, and the elastic bump is deformed under pressure, and has a tendency to outwardly open the inner wall of the bottom opening of the second reagent chamber 2, thereby Achieve interference fit and seal.

The second reagent cartridge 2 is installed at an upper portion inside the first reagent cartridge 1, and the outer wall of the second reagent cartridge 2 is The inner wall of the first reagent cartridge 1 is sealingly connected. Specifically, the outer wall of the second reagent cartridge 2 is provided with a sealing boss 204, and the sealing boss 204 extends outward in the radial direction of the second reagent cartridge 2, and the outer edge of the sealing boss 204 and the first reagent chamber The inner wall of 1 abuts. The number of the sealing bosses 204 is three, and the three sealing bosses 204 are arranged in order from the top to the bottom along the length direction of the second reagent cartridge 2. The longitudinal direction of the sealing boss 204 is triangular.

The cover 3 is capped on the opening at the top of the second reagent cartridge 2, and the inner side wall of the cover 3 is sealingly connected to the outer wall of the first reagent cartridge 1. Specifically, the inner side wall of the cover body 3 is provided with a first-stage sealing flange 304 and a second-stage sealing flange 303. The first-stage sealing flange 304 and the second-stage sealing flange 303 are all along the diameter of the cover body 3. Inwardly extending in the direction, the first-stage sealing flange 304 is located below the second-stage sealing flange 303; the outer edge of the first-stage sealing flange 304 is connected to the outer wall 4 of the first reagent cartridge 1, and the second-stage sealing The outer edge of the flange 303 is placed on the top edge of the top of the first reagent cartridge 1; the fixed end of the column 401 is fixedly connected to the top of the sealing member 4, and the column 401 is located in the second reagent cartridge 2 and along the second reagent cartridge 2 The inner top wall of the cover 3 extends downwardly with a lower pressing boss 302. The position of the lower pressing boss 302 corresponds to the position of the column 401, and the bottom surface of the pressing boss 302 is opposite to the top surface of the column 401. Contact; the distance between the second stage sealing flange 303 and the top wall of the cover 3 is greater than or equal to the distance between the top of the seal 4 and the bottom of the second reagent cartridge 2. The number of columns 401 can be two.

An optical surface 102 is provided on the side and bottom surfaces of the lower portion of the first reagent cartridge 1. In order to prevent the user from accidentally touching the optical surface by hand or other objects, causing pollution or scratching, affecting the test effect, the lower portion of the first reagent chamber 1 is provided with an optical protection surface 101, and the optical protection surface 101 is provided with a light-passing groove 103. The position of the light groove 103 corresponds to the optical surface 102.

In order to prevent the cover body 3 from slipping off the first reagent compartment 1 when the cover body 3 is opened, the outer wall of the cover body 3 is connected to an anti-dropping loop belt 301 which is sleeved on the upper portion of the first reagent cartridge 1. On the outer wall. The lid body 3 of the present embodiment can be made of a hard material and can be directly opened from the anti-shedding belt 301. The lower container of the first reagent cartridge 1 can be formed into a concave shape, and the optical protection surface 101 can be formed in a plane with the outside without affecting the appearance. The seal 4 can have a square structure.

The usage of this embodiment is as follows:

The R1 reagent is added to the first reagent chamber 1, the sealing member 4 is mounted on the opening at the bottom of the second reagent chamber 2, the R2 reagent is added to the second reagent chamber 2, and the lid body 3 is closed to make the first stage The sealing flange 304 is connected to the outer wall 4 of the first reagent cartridge 1, and the second-stage sealing flange 303 is placed at the top position of the first reagent cartridge 1, and the anti-drop ring 301 is sleeved in the first reagent cartridge. On the outer wall of 1. The ratio parameter of the R1 reagent to the R2 reagent and the calibration parameter determined in advance are used to prepare a barcode with corresponding information, and the barcode is attached to the outside of the cuvette.

When using, the user can first read the pre-measured calibration parameters by scanning the barcode, then open the cover 3, add the sample into the second reagent chamber 2, cover the cover 3, and press down firmly, the cover 3 The pressing boss 302 pushes the column 401 downward, and finally the sealing member 4 is detached from the opening of the bottom of the second reagent chamber 2, and the sample and the R2 reagent enter the first reagent chamber 1 and react with the R1 reagent. complete test. Throughout the testing process, users only need to join the sample to complete the test, so as to achieve the purpose of the user operation process and professional skills, and improve the test speed.

Embodiment 2

As shown in FIGS. 7 to 11, a reagent pre-packaged cuvette includes a first reagent cartridge 5 having an opening at the top, a second reagent cartridge 7 having an opening at the top and the bottom, a seal 8 and a cover. Body 6.

The seal 8 is interference fit with the opening at the bottom of the second reagent cartridge 7, and the seal 8 is sealed to the opening at the bottom of the second reagent cartridge 7.

The second reagent cartridge 7 is mounted on the upper portion inside the first reagent cartridge 5, and the outer wall of the second reagent cartridge 7 is sealingly connected to the inner wall of the first reagent cartridge 5. Specifically, the outer wall of the second reagent chamber 7 is provided with a sealing boss 701. The sealing boss 701 extends outward in a radial direction of the second reagent cartridge 7, and an outer edge of the sealing boss 701 abuts against an inner wall of the first reagent cartridge 5. The number of the sealing bosses 701 is three, and the three sealing bosses 701 are arranged in order from the top to the bottom in the longitudinal direction of the second reagent cartridge 5. The longitudinal direction of the sealing boss 701 has a triangular shape.

The cover 6 is capped on the opening at the top of the second reagent cartridge 7, and the inner side wall of the cover 6 is sealingly connected to the outer wall of the first reagent cartridge 5. Specifically, the cover body 6 of the embodiment can be made of a silicone material, and the inner top wall of the cover body 6 extends downwardly with a sealing protrusion 602. The sealing protrusion 602 is sealingly connected with the opening of the top of the second reagent chamber 7, that is, The diameter of the sealing projection 602 may be slightly larger than the diameter of the opening at the top of the second reagent cartridge 7, so that the sealing projection 602 plugs the opening at the top of the second reagent cartridge 7 like a plug, thereby achieving a sealed connection. The inner side wall of the cover body 6 is provided with a sealing flange 603 which extends inward in the radial direction of the cover body 6, and the outer edge of the sealing flange 603 is connected to the outer wall 4 of the first reagent cartridge 5.

An optical surface 503 is provided on the side and bottom surfaces of the lower portion of the first reagent cartridge 1. In order to prevent the user from accidentally touching the optical surface by hand or other objects, causing pollution or scratching, affecting the test effect, the lower portion of the first reagent chamber 5 is provided with an optical protection surface 501, and the optical protection surface 501 is provided with a light-passing groove 502. The position of the light groove 502 corresponds to the optical surface 503.

In order to prevent the cover body 6 from sliding off the first reagent compartment 5, the outer wall of the cover body 6 is connected with an anti-dropping loop belt 601, and the anti-dropping loop belt 601 is sleeved on the upper part of the first reagent compartment 1. On the outer wall. The cover body 6 and the fall-preventing endless belt 601 of this embodiment are separately molded.

The method of use of this embodiment is basically the same as that of the first embodiment. The only difference is that when the user uses the cover body 6 to open the sample, the nozzle 8 needs to be pushed away by the pipette tip.

Embodiment 3

The difference between this embodiment and the first embodiment lies in the connection relationship between the cover body and the column. The details are as follows: The cover body 3A does not need to be provided with a lower pressing boss, and the fixed end of the column 401A is fixedly connected with the top of the sealing member 4. , The free end of the column 401A is in contact with the top wall of the cover 3A; the distance between the second stage sealing flange and the top wall of the cover 3A is greater than or equal to between the top of the seal 4 and the bottom of the second reagent cartridge 2 distance.

The method of use of this embodiment is basically the same as that of the first embodiment. The only difference is that the sealing member 4 can be detached from the opening of the bottom of the second reagent chamber 2 by directly pressing the column 401A with the inner top wall of the cover 3A.

Further, the optical surface of the above embodiment may be provided only on the bottom surface or the side surface of the first reagent cartridge.

It can be seen from the above embodiments that the present invention realizes the medical inspection and analysis instruments such as biochemical analyzers, immunoanalyzers and the like on various automatic, semi-automatic or instant diagnostic equipments, and the reagents are pre-packaged on the cuvette, thereby completing the operation. , reducing the user technology threshold.

Various other changes and modifications may be made by those skilled in the art in light of the above-described technical solutions and concepts, and all such changes and modifications are intended to fall within the scope of the appended claims.

Claims

Claim

A reagent pre-packaged cuvette, comprising: a first reagent chamber having an opening at the top, a second reagent chamber having an opening at the top and the bottom, a sealing member, and a cover; the sealing member and the second The opening at the bottom of the reagent cartridge is interference fit, and the seal is sealed with the opening at the bottom of the second reagent cartridge; the second reagent cartridge is installed at the upper portion of the inner side of the first reagent cartridge, and the outer wall of the second reagent cartridge and the inner wall of the first reagent cartridge The cover is mounted on the opening of the top of the second reagent cartridge, and the inner side wall of the cover is sealingly connected to the outer wall of the first reagent cartridge; the side surface and/or the bottom surface of the lower portion of the first reagent cartridge is provided with an optical surface.

2. The reagent prepackaged cuvette according to claim 1, wherein the outer wall of the second reagent cartridge is provided with a sealing boss, and the sealing boss extends outward in a radial direction of the second reagent cartridge. The outer edge of the sealing boss is connected to the inner wall 4 of the first reagent cartridge.

3. The reagent pre-packaged cuvette according to claim 2, wherein the number of sealing bosses is three, and the three sealing bosses are arranged in a row from top to bottom along the length direction of the second reagent cartridge.

4. The reagent prepackaged cuvette according to claim 2, wherein the sealing boss has a triangular cross section.

5. The reagent pre-packaged cuvette according to claim 1, wherein the reagent pre-package cuvette further comprises a column; the inner side wall of the cover body is provided with a first-stage sealing flange, and the second-stage sealing a flange, a first-stage sealing flange, a second-stage sealing flange extending inward in a radial direction of the cover body, the first-stage sealing flange being located below the second-stage sealing flange; the first-stage sealing flange The outer edge is connected to the outer wall of the first reagent cartridge, and the outer edge of the second sealing flange is placed on the top edge of the top of the first reagent cartridge; the fixed end of the column is fixedly connected to the top of the seal, and the column is located at the second reagent The inside of the chamber is disposed along the length of the second reagent chamber; the inner top wall of the cover body has a lower pressing boss extending downward, and the position of the lower pressing boss corresponds to the position of the column, and the bottom surface and the column of the lower pressing boss The top surface is in contact; the distance between the second stage sealing flange and the top wall of the cover is greater than or equal to the distance between the top of the seal and the bottom of the second reagent cartridge.

6 . The reagent pre-packaged cuvette according to claim 1 , wherein the reagent pre-package cuvette further comprises a column; the inner side wall of the cover body is provided with a first-stage sealing flange and a second-stage sealing. a flange, a first-stage sealing flange, a second-stage sealing flange extending inward in a radial direction of the cover body, the first-stage sealing flange being located below the second-stage sealing flange; the first-stage sealing flange The outer edge of the first reagent cartridge is connected to the outer wall of the first reagent cartridge, and the outer edge of the second sealing flange is placed on the top edge of the top of the first reagent cartridge; the fixed end of the pillar is fixedly connected with the top of the seal, and the column is free. The end is in contact with the top wall of the cover body, the column is located in the second reagent chamber and disposed along the length of the second reagent chamber; the distance between the second-stage sealing flange and the top wall of the cover body is greater than or equal to the top of the seal The distance between the bottoms of the second reagent compartment.

7. The reagent pre-packaged cuvette according to claim 1, wherein the inner top wall of the cover body has a sealing protrusion extending downwardly, and the sealing protrusion is sealingly connected to the opening of the top of the second reagent chamber.

8. The reagent prepackaged cuvette according to claim 7, wherein the inner side wall of the cover body is provided with a sealing flange, and the sealing flange extends inward in the radial direction of the cover body, and the sealing flange is sealed. The outer edge abuts the outer wall of the first reagent cartridge.

The reagent pre-packaged cuvette according to any one of claims 1 to 8, wherein the outer wall of the cover is connected with an anti-drop ring, and the anti-drop ring is sleeved on the upper part of the first reagent cartridge. On the outer wall.

The reagent pre-packaged cuvette according to any one of claims 1 to 8, wherein the lower portion of the first reagent chamber is provided with an optical protection surface, and the optical protection surface is provided with a light-passing groove, and the light-passing groove The position corresponds to the optical surface.