WO2013062294A3 - 미티글리나이드 칼슘염의 개선된 제조방법 - Google Patents

미티글리나이드 칼슘염의 개선된 제조방법 Download PDF

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Publication number
WO2013062294A3
WO2013062294A3 PCT/KR2012/008737 KR2012008737W WO2013062294A3 WO 2013062294 A3 WO2013062294 A3 WO 2013062294A3 KR 2012008737 W KR2012008737 W KR 2012008737W WO 2013062294 A3 WO2013062294 A3 WO 2013062294A3
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WO
WIPO (PCT)
Prior art keywords
mitiglinide calcium
improved preparation
calcium
mitiglinide
preparing
Prior art date
Application number
PCT/KR2012/008737
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English (en)
French (fr)
Other versions
WO2013062294A2 (ko
Inventor
나영준
한주애
반지영
조동옥
Original Assignee
주식회사 메디켐코리아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 메디켐코리아 filed Critical 주식회사 메디켐코리아
Publication of WO2013062294A2 publication Critical patent/WO2013062294A2/ko
Publication of WO2013062294A3 publication Critical patent/WO2013062294A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/04—Calcium compounds

Abstract

본 발명은 미티글리나이드 칼슘염의 개선된 제조방법에 관한 것으로서, 더욱 상세하게는 2-벤질숙시닉 에시드를 출발물질로 사용하여 2-벤질-1-이미다졸-4-(옥타하이드로-아이소인돌-2-일)-부탄-1,4-다이온을 신규 중간체로 합성하고, 이를 염기 존재하에서 칼슘염으로 전환하는 과정을 포함하는 간결한 제조과정을 수행하여 당뇨병 치료제로 유용한 미티글리나이드(Mitiglinide)의 칼슘염을 효율적으로 제조하는 방법에 관한 것이다.
PCT/KR2012/008737 2011-10-27 2012-10-24 미티글리나이드 칼슘염의 개선된 제조방법 WO2013062294A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110110656A KR101327866B1 (ko) 2011-10-27 2011-10-27 미티글리나이드 칼슘염의 개선된 제조방법
KR10-2011-0110656 2011-10-27

Publications (2)

Publication Number Publication Date
WO2013062294A2 WO2013062294A2 (ko) 2013-05-02
WO2013062294A3 true WO2013062294A3 (ko) 2013-06-20

Family

ID=48168720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/008737 WO2013062294A2 (ko) 2011-10-27 2012-10-24 미티글리나이드 칼슘염의 개선된 제조방법

Country Status (2)

Country Link
KR (1) KR101327866B1 (ko)
WO (1) WO2013062294A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008312B (zh) * 2016-08-15 2018-06-29 河南中医学院 一种降糖药物米格列奈钙的制备方法
CN107963989A (zh) * 2017-12-22 2018-04-27 江西济民可信药业有限公司 一种米格列奈钙的制备方法
CN109081805A (zh) * 2018-08-24 2018-12-25 江西济民可信药业有限公司 一种改进的米格列奈钙的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06340623A (ja) * 1993-05-28 1994-12-13 Kissei Pharmaceut Co Ltd ベンジルコハク酸誘導体の製造方法およびその製造中間体
EP0967204A1 (en) * 1997-01-29 1999-12-29 Kissei Pharmaceutical Co. Ltd. Process for producing benzylsuccinic acid derivatives
US6133454A (en) * 1997-07-03 2000-10-17 Adir Et Compagnie Method for preparing a substituted perhydroisoindole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06340623A (ja) * 1993-05-28 1994-12-13 Kissei Pharmaceut Co Ltd ベンジルコハク酸誘導体の製造方法およびその製造中間体
EP0967204A1 (en) * 1997-01-29 1999-12-29 Kissei Pharmaceutical Co. Ltd. Process for producing benzylsuccinic acid derivatives
US6133454A (en) * 1997-07-03 2000-10-17 Adir Et Compagnie Method for preparing a substituted perhydroisoindole

Also Published As

Publication number Publication date
KR101327866B1 (ko) 2013-11-11
WO2013062294A2 (ko) 2013-05-02
KR20130046213A (ko) 2013-05-07

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