WO2013046868A1 - Seringue - Google Patents

Seringue Download PDF

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Publication number
WO2013046868A1
WO2013046868A1 PCT/JP2012/068003 JP2012068003W WO2013046868A1 WO 2013046868 A1 WO2013046868 A1 WO 2013046868A1 JP 2012068003 W JP2012068003 W JP 2012068003W WO 2013046868 A1 WO2013046868 A1 WO 2013046868A1
Authority
WO
WIPO (PCT)
Prior art keywords
outer cylinder
living body
puncture needle
syringe
pusher
Prior art date
Application number
PCT/JP2012/068003
Other languages
English (en)
Japanese (ja)
Inventor
広孝 大橋
陽一郎 岩瀬
立川　浩一
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2013046868A1 publication Critical patent/WO2013046868A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/422—Desensitising skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion

Definitions

  • the present invention relates to a syringe.
  • the syringe is generally composed of an outer cylinder, a gasket that can slide in the outer cylinder, and a plunger that moves the gasket.
  • the outer cylinder has a trunk
  • Such a syringe is configured to move the gasket toward the distal end side by pushing the pusher into the outer cylinder, thereby guiding the chemical stored in the outer cylinder to the outside of the outer cylinder from the opening of the mouth. (For example, refer to Patent Document 1).
  • Patent Document 1 The syringe described in Patent Document 1 is used as follows, for example. With the puncture needle connected to the mouth, hold the outer tube with four fingers except the thumb, puncture the skin with the thumb on the pusher, and maintain the state with the thumb. The drug solution is administered by pushing the pusher. In addition, with the puncture needle connected to the mouth, the outer tube is held between the index finger and the middle finger, and the puncture needle is punctured into the skin with the thumb placed on the pusher, and the thumb is maintained while maintaining the state. The drug solution is administered by pushing the pusher in.
  • An object of the present invention is to provide a syringe with excellent operability.
  • the present invention provides an outer cylinder having a mouth on the tip side, A puncture needle connected to the mouth and having a needle tip capable of puncturing a living body; A gasket that can slide in the outer cylinder; A chemical solution stored in a space surrounded by the outer cylinder and the gasket; An abutting portion that abuts the living body prior to puncturing the living body with the puncture needle; A pusher which is provided so as to be movable in the longitudinal direction of the outer cylinder with respect to the outer cylinder, and which moves the gasket toward the distal end side of the outer cylinder; Movement restricting means for restricting movement of the pusher toward the distal end side with respect to the outer cylinder, The pusher covers at least a part of the outer periphery of the outer cylinder and is connected to the cylindrical gripping part provided to be movable in the longitudinal direction of the outer cylinder with respect to the outer cylinder.
  • a pressing portion that is inserted into the outer cylinder and moves the gasket toward the distal end side by moving the gripping portion toward the distal end side with respect to the outer cylinder;
  • the contact portion has an accommodating portion that opens to the distal end side and accommodates the puncture needle inside.
  • the restriction by the movement restricting means is released, and the pusher is distal to the outer cylinder.
  • the syringe is configured to move to the side, whereby the gasket moves to the distal end side, and the drug solution is injected into the living body from the puncture needle.
  • the contact portion has a dome-shaped base and a plurality of slits formed from the outer periphery to the center of the base.
  • the contact portion is crushed in the longitudinal direction of the outer cylinder, and the opening of the storage portion is expanded. It is preferable to deform it.
  • the contact portion has a plurality of divided pieces divided by the slit, and a weakened portion provided in the middle of the extending direction of the divided pieces, and the pusher is It is preferable that when the first pressing force is pushed into the living body, the divided piece is deformed so as to be bent at the fragile portion.
  • the abutting portion is broken when the divided piece is bent at the weakened portion.
  • the contact portion protrudes into the storage portion, and has a protruding portion provided to surround the puncture needle,
  • the protrusion preferably presses the living body in a state where the contact portion is deformed by the first pressing force.
  • the movement restricting means is configured to be damaged by the second pressing force.
  • FIG. 1 is a longitudinal sectional view showing a first embodiment of the syringe of the present invention.
  • FIG. 2 is a perspective view of a contact portion of the syringe shown in FIG.
  • FIG. 3 is a schematic diagram illustrating an example of a method of using the syringe shown in FIG.
  • FIG. 4 is a longitudinal sectional view showing a second embodiment of the syringe of the present invention.
  • FIG. 1 is a longitudinal sectional view showing a first embodiment of the syringe of the present invention
  • FIG. 2 is a perspective view of an abutting portion of the syringe shown in FIG. 1
  • FIG. 3 is a method of using the syringe shown in FIG. It is a schematic diagram explaining an example.
  • the upper side in FIGS. 1 and 3 is referred to as a “base end” and the lower side is referred to as a “tip”.
  • the state where no syringe is used and no external force is applied to the syringe that is, the state shown in FIG. 1 is also referred to as “unused state”.
  • a syringe used for “intradermal injection” in which the drug solution 100 is administered between the epidermis and the dermis will be described as a representative.
  • the use of the syringe of the present invention is not limited to this, and for example, a drug solution You may apply to "subcutaneous injection” which administers 100 to subcutaneous tissue, and “muscular injection” which administers the chemical
  • a syringe 1 shown in FIG. 1 is a prefilled syringe in which a chemical solution 100 is stored in advance.
  • a syringe 1 includes an outer cylinder 2, a puncture needle 6 provided with the outer cylinder 2, a gasket 3 that can slide in the outer cylinder 2, a pusher 4 that moves the gasket 3, and a puncture needle.
  • a contact portion 5 that contacts the skin and a spring member (biasing means) 9 that biases the outer cylinder 2 against the contact portion 5 are provided prior to puncturing 6, a contact portion 5 that contacts the skin and a spring member (biasing means) 9 that biases the outer cylinder 2 against the contact portion 5 are provided.
  • a liquid chemical solution 100 is stored in advance in a space 11 surrounded by the outer cylinder 2 and the gasket 3, which is located on the tip side of the gasket 3.
  • a vitamin agent total vitamin agent
  • various amino acids antithrombotic agents like heparin, insulin, antibiotics, an antitumor agent, an analgesic agent, a cardiotonic agent, an intravenous anesthetic agent, Antiparkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents, correction electrolytes, protease inhibitors, thromboxane synthesis inhibitors and the like can be mentioned.
  • the amount of the chemical solution 100 stored in the space is not particularly limited, but is about 0.02 to 2.0 mL, for example.
  • the outer cylinder 2 is composed of a bottomed cylindrical member. As shown in FIG. 1, the outer cylinder 2 includes a barrel portion 21 having a bottom portion 211, a plate-like flange 27 provided on the outer periphery of the proximal end of the barrel portion 21, and a central portion of the bottom portion 211. 21 and a mouth portion 22 having a reduced diameter with respect to 21, and these are integrally formed.
  • Examples of the constituent material of the outer cylinder 2 include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, Various resins such as polyesters such as polyethylene terephthalate and polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. Resin such as polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) is preferable because it is easy to mold.
  • the outer cylinder 2 is substantially transparent in order to ensure internal visibility.
  • the puncture needle 6 is provided at the mouth portion 22 of the outer cylinder, and the needle tip projects from the mouth portion 22 toward the distal end side.
  • the puncture needle 6 has a needle tip that can puncture a living body, and the medical solution 100 stored in the outer cylinder 2 can be injected (administered) into the living body by puncturing the living body with the needle tip. .
  • the puncture needle 6 has a size of 26 to 33 G (outer diameter: 0.2 to 0.45 mm) based on the ISO medical needle tube standard (ISO9626: 1991 / Amd.1: 2001 (E)). Is preferably used, and more preferably 30 to 33G in size.
  • the length of the portion of the puncture needle 6 protruding from the mouth portion 22, that is, the depth of puncture into the living body is not particularly limited, but is within the range of 0.5 mm to 3.0 mm. It is preferably set. Since the thickness of the epidermis is approximately 0.5 to 3.0 mm, setting the puncture depth within the above range makes the syringe 1 more suitable for intradermal injection.
  • the constituent material of the puncture needle 6 is not particularly limited.
  • various metal materials such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy, a superelastic alloy such as a Ni—Ti alloy, polyphenylene sulfide, and the like.
  • Various hard resin materials are mentioned.
  • the puncture needle 6 is covered with a cap 7. Thereby, the puncture needle 6 is protected and erroneous puncture of the puncture needle 6 can be prevented.
  • the cap 7 is used by being removed when the syringe 1 is used. Considering ease of removal, it is preferable that the cap 7 has a shape protruding from the tip of the contact portion 5.
  • a gasket 3 made of an elastic material is accommodated in the outer cylinder 2.
  • a plurality of ring-shaped protrusions are formed on the entire outer periphery of the gasket 3, and the protrusions slide while being in close contact with the inner peripheral surface of the outer cylinder 2. While holding more reliably, slidability can be improved.
  • the constituent material of the gasket 3 is not particularly limited.
  • various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide,
  • elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.
  • the contact portion 5 has a function of stabilizing the posture of the syringe 1 by bringing it into contact with the epidermis (living body) prior to the puncture of the puncture needle 6 when using the syringe 1.
  • such a contact portion 5 is fixed to the mouth portion 22 of the outer cylinder 2. Further, the contact portion 5 has a dome shape (umbrella shape) curved toward the distal end side, and is configured to be elastically deformable. Moreover, the contact part 5 has the accommodating part 5a comprised by the recessed part open
  • the contact portion 5 can be brought into contact with the entire periphery of the portion where the puncture needle 6 is punctured. Therefore, the posture of the syringe 1 is stable, and the puncture needle 6 can be maintained in a posture substantially perpendicular to the epidermis.
  • the height L of the storage portion 5a in the unused state is not particularly limited as long as the puncture needle 6 can be stored, but before the puncture needle 6 is punctured, the contact portion 5 is applied with an appropriate pressing force by the epidermis. Is set so that the puncture needle 6 is punctured securely.
  • the height L is appropriately set according to the opening diameter of the storage portion 5a. For example, when the opening diameter is about 10 mm, the height L is set within a range of 0.75 mm to 2.6 mm. preferable.
  • such a contact portion 5 includes a dome-shaped base 51 and a plurality of slits (cuts) 52 formed radially from the outer periphery of the base 51 toward the center.
  • a plurality of divided pieces 53 that are divided by the slits 52 and that have free ends are formed on the outer peripheral portion of the base 51.
  • a through hole 511 is formed at the center of the base 51, and the mouth portion 22 of the outer cylinder 2 is fitted into the through hole 511. Thereby, the contact part 5 is fixed to the outer cylinder 2.
  • mouth part 22 is not specifically limited, For example, you may fix by screwing.
  • the slit 52 is formed to facilitate the deformation of the contact portion 5.
  • the number of slits 52 varies depending on the size of the contact portion 5 and the like, but is preferably about 4 to 16, for example.
  • the base 51 has a protruding portion 512 that protrudes into the storage portion 5a.
  • the protruding portion 512 is formed in a substantially annular shape centering on the mouth portion 22, but is divided into a plurality of portions by the slit 52. In the unused state, the distal end of each projecting portion 512 is located closer to the proximal end than the opening of the storage portion 5a.
  • the tip of puncture needle 6 is located in a region surrounded by a plurality of protrusions 512.
  • the contact portion 5 when the contact portion 5 is pressed against the outer skin by a force (first pressing force; external force G1 described later) having a predetermined magnitude or more, the contact portion 5 is crushed in that direction, The opening diameter is deformed so as to increase. And when the contact part 5 deform
  • first pressing force external force G1 described later
  • the constituent material of the contact portion 5 is not particularly limited as long as it can be elastically deformed.
  • the same material as the constituent material of the outer cylinder 2 can be used.
  • the pusher 4 is provided so as to be movable in the longitudinal direction of the outer cylinder 2 with respect to the outer cylinder 2. As shown in FIG. 1, the pusher 4 includes a grip portion 41 that is gripped by the user and a pressing portion 42 that presses the gasket 3. In the present embodiment, the grip portion 41 and the pressing portion 42 are integrally formed.
  • the pressing portion 42 has a rod shape and is inserted into the outer cylinder 2 from the tip side.
  • the pressing portion 42 is connected to the bottom portion of the grip portion 41 at the base end portion. Further, the pressing portion 42 is in contact with the gasket 3 in an unused state. Therefore, when the pusher 4 is moved toward the distal end side with respect to the outer cylinder 2, the pressing portion 42 presses the gasket, and the gasket 3 moves toward the distal end side of the outer cylinder 2.
  • the pressing portion 42 may be separated from the gasket in an unused state, or the pressing portion 42 may be connected to the gasket 3. However, it is preferable that the pressing portion 42 is not connected to the gasket 3. As a result, after the gasket 3 is moved to the distal end side by the pusher 4, the gasket 3 cannot be moved to the proximal end side even if the pusher 4 is moved to the proximal end side. Use (refilling of the chemical solution 100) is prevented, and the safety of the syringe 1 is improved.
  • the gripping portion 41 has a bottomed cylindrical shape having a bottom portion, and covers the entire circumferential direction of the outer tube 2 and the contact portion 5. By making the holding part 41 into such a shape, it becomes easy to hold the syringe 1 and the operability of the syringe 1 is improved.
  • At least one groove 411 is formed on the inner wall of the grip portion 41.
  • the groove 411 extends in the longitudinal direction of the syringe 1 and a part of the flange 27 is engaged therewith.
  • the groove 411 functions as a guide when the pusher 4 and the outer cylinder 2 slide, whereby the sliding becomes smooth.
  • the groove 411 also has a function of preventing the pusher 4 from rotating in the circumferential direction with respect to the outer cylinder 2.
  • the grip portion 41 is provided with a claw portion (engagement portion) 412 provided so as to protrude inside.
  • the claw portion 412 is in contact with the proximal end surface of the flange 27 of the outer cylinder 2 in the unused state, and thereby the movement of the pusher 4 to the distal end side with respect to the outer cylinder 2 in the unused state. It is regulated. That is, the claw portion 412 constitutes a movement restricting means 200 that restricts the movement of the pusher 4 toward the distal end side with respect to the outer cylinder 2.
  • such a claw portion 412 is a force that moves the pusher 4 toward the distal end side with respect to the outer cylinder 2 and has a force greater than a predetermined magnitude (second pressing force; an external force described later).
  • a predetermined magnitude second pressing force; an external force described later.
  • the external force G2 that can damage the claw portion 412 is set to be larger than the force that can deform the contact portion 5 (external force G1). That is, when the external force G1 acts on the syringe 1, the contact portion 5 is deformed so as to be crushed, but the claw portion 412 is not damaged.
  • the flange 27 In the unused state, the flange 27 is in contact with the tip of the groove 411 and is in contact with the claw portion 412. Thereby, in the unused state, the relative positional relationship between the outer cylinder 2 and the pusher 4 is kept constant. Therefore, these do not move carelessly and the safety and operability of the syringe 1 are improved.
  • the overall length and width (outer diameter) of the grip portion 41 are not particularly limited as long as the grip portion 41 can be gripped.
  • the holding part 41 may be comprised so that the outer cylinder 2 located inside can be visually recognized. Thereby, since the state of the chemical
  • a configuration is not particularly limited, and for example, a method of configuring the grip portion 41 with a transparent member can be mentioned.
  • grip part 41 is colored, the elongate window part extended in a longitudinal direction may be provided in these, and it may be made to visually recognize an inside through this window part.
  • the window part may be comprised with the transparent member and may be comprised with the through-hole.
  • the constituent material of the pusher 4 is not particularly limited, and for example, the same material as the constituent material of the outer cylinder 2 can be used.
  • the abutting portion 5 is brought into contact with a site (skin) to which the drug solution 100 such as an arm is administered, while holding the grasping portion 41.
  • the contact portion 5 is pressed against the skin with a predetermined strength. As a result, an external force G1 acts on the contact portion 5. Since the contact portion 5 is set to be deformed by the external force G1, when the external force G1 is applied, the contact portion 5 is deformed so that the opening of the storage portion 5a is expanded while being crushed. As a result, the epidermis around the site where the puncture needle 6 is punctured (hereinafter also simply referred to as “puncture site”) is pulled outward, that is, in a direction away from the puncture site, and tension is applied to the epidermis.
  • Puncture site the epidermis around the site where the puncture needle 6 is punctured
  • the projecting portion 512 moves to the tip side, and the tip portion presses the epidermis.
  • the epidermis inside the protruding portion 512 swells in a mountain shape, and the puncture needle 6 takes a posture substantially perpendicular to the epidermis.
  • the puncture needle 6 can be reliably punctured into the living body.
  • the protrusion part 512 presses an epidermis
  • the puncture needle 6 protrudes from the front-end
  • the positional relationship between the puncture needle 6 and the epidermis is regulated by the contact portion 5 and the mouth portion 22, whereby the needle tip reaches a predetermined depth. Thereby, it will be in a puncture state.
  • the puncture needle 6 can be punctured into the living body and the drug solution 100 can be administered simply by gripping the grasping portion 41 and pressing the syringe 1 against the living body. That is, according to the syringe 1, administration of the chemical solution 100 is completed in one step. Moreover, according to the syringe 1, since the chemical
  • the posture of the syringe 1 can be stabilized by bringing the contact portion 5 into contact with the epidermis before the puncture needle 6 is punctured. Therefore, the operability of the syringe 1 is improved.
  • the outer peripheral portion of the contact portion 5 of the present embodiment is divided into a plurality of divided pieces 53 by slits 52, and each divided piece 53 is independently deformed along the shape of the epidermis. Can be more stable.
  • the puncture needle 6 in order to puncture the living body with the puncture needle 6 in the operation [3], it is necessary to deform the contact portion 5. Therefore, the user must press the contact portion 5 against the skin with a certain large pressing force. When the contact portion 5 is pressed against the epidermis with such a force, the outer cylinder 2 moves to the tip side vigorously, and the puncture needle 6 is punctured into the living body vigorously. Therefore, the puncture needle 6 can be punctured into the living body more reliably.
  • the length of the puncture needle 6 (puncture depth) is as short as about 0.5 mm to 3.0 mm. Therefore, for example, when the puncture needle 6 is slowly punctured into the living body, there is a possibility that the puncture needle 6 may not be punctured into the living body simply because the epidermis is pressed by the puncture needle 6 and recessed.
  • the puncture needle 6 is punctured into the living body vigorously by the user's operation like the syringe 1
  • the above-described problems can be solved and the puncture needle 6 can be punctured into the living body reliably. .
  • the contact portion 5 is deformed so that the opening of the storage portion 5a is expanded while being crushed by the application of the external force G1.
  • the diameter of the opening of the storage portion 5a expands the epidermis around the puncture site, the sagging of the epidermis can be reduced, and the puncture needle 6 can be punctured more reliably. Can do.
  • the syringe 1 is configured such that the claw portion 412 is broken during the operation. Thereby, since the syringe 1 once used cannot be reused, the safety of the syringe 1 is improved.
  • FIG. 4 is a longitudinal sectional view showing a second embodiment of the syringe of the present invention.
  • the syringe of the present embodiment is the same as the syringe of the first embodiment except that the configuration of the contact portion is different.
  • each of the divided pieces 53 included in the contact portion 5A is formed with a fragile portion 54A that is thinner than other portions.
  • the fragile portion 54A is formed in the entire width direction of each divided piece 53. Further, each fragile portion 54 ⁇ / b> A is located closer to the proximal end than the distal end of the protruding portion 512.
  • the contact portion 5 having such a configuration is pressed against the skin by a force of a predetermined magnitude or more, and when the external force G1 described in the first embodiment is applied, the contact portion 5 is deformed so that the opening is expanded while being crushed.
  • the front end side is bent from the fragile portion 54A of each divided piece 53 so as to be broken.
  • the protruding portion 512 and the puncture needle 6 protrude from the storage portion 5a toward the distal end, the protruding portion 512 presses the epidermis, and the puncture needle 6 is punctured into the living body.
  • the puncture needle 6 can be punctured more reliably into the living body.
  • the distal end side in order to puncture the living body with the puncture needle 6, the distal end side must be bent from the fragile portion 54 ⁇ / b> A of each divided piece 53.
  • the user in order to puncture the living body with the puncture needle 6, the distal end side must be bent from the fragile portion 54 ⁇ / b> A of each divided piece 53.
  • the user must press the contact portion 5 against the skin with a large pressing force.
  • each divided piece 53 is bent at the fragile portion 54A, and the puncture needle 6 is moved to the tip side vigorously and punctured into the living body vigorously. Therefore, the puncture needle 6 can be punctured into the living body more reliably.
  • the contact portion 5 is configured to be broken by being bent at the fragile portion 54A. Therefore, since the syringe 1A once used cannot be reused, the safety of the syringe 1A is improved.
  • the syringe of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • a syringe excellent in operability can be provided. Specifically, for example, when a gripping part is gripped and pressed against a living body, the abutting part first contacts the living body and the posture of the syringe is maintained. When the gripping part is further pressed against the living body, the puncture needle is pressed against the living body. When the puncture is performed and the grasping portion is further pressed against the living body, the drug solution is injected from the puncture needle into the living body. That is, the administration of the drug solution is completed in one step of pressing the grip portion against the living body.
  • the puncture needle can be punctured into the living body vigorously, for example, even when the puncture needle is short, the puncture needle can be reliably punctured into the living body. From the above, the syringe has excellent operability. Furthermore, by improving operability, administration errors can be prevented, and reliability and safety are also improved.

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  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une seringue (1) qui a un tube externe (2) sur lequel une aiguille de perforation (6) est disposée, un joint d'étanchéité (3) qui peut coulisser à l'intérieur du tube externe (2), une solution de médicament (100) stockée à l'intérieur du tube externe (2), une partie de contact (5) qui vient en contact avec un corps vivant avant la perforation du corps vivant avec l'aiguille de perforation (6), un piston plongeur (4) qui déplace le joint d'étanchéité (3) vers le côté extrémité de pointe, et un moyen de limitation de déplacement (200) pour limiter le déplacement du piston plongeur (4) vers le côté extrémité de pointe du tube externe (2). Dans la seringue (1) ayant ladite configuration, la partie de contact (5) se déforme d'une manière à s'écraser lorsque le piston plongeur (4) est pressé contre le corps vivant à une première force de pression tandis que la partie de contact (5) vient en contact avec le corps vivant.
PCT/JP2012/068003 2011-09-29 2012-07-13 Seringue WO2013046868A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011215193 2011-09-29
JP2011-215193 2011-09-29

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Publication Number Publication Date
WO2013046868A1 true WO2013046868A1 (fr) 2013-04-04

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PCT/JP2012/068003 WO2013046868A1 (fr) 2011-09-29 2012-07-13 Seringue

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016158756A1 (fr) * 2015-03-31 2016-10-06 テルモ株式会社 Formulation intradermique pour la médecine régénérative
EP3603731A4 (fr) * 2017-03-31 2020-07-15 Toppan Printing Co., Ltd. Dispositif d'administration percutanée
JPWO2020138193A1 (ja) * 2018-12-25 2021-02-18 国立大学法人弘前大学 薬剤投与デバイス、及び薬剤投与システム
WO2022030457A1 (fr) 2020-08-05 2022-02-10 株式会社ライトニックス Dispositif de dosage médical

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002315741A (ja) * 2001-03-26 2002-10-29 Bayer Corp 穿刺装置用の加圧リング
JP2003534881A (ja) * 2000-06-06 2003-11-25 ベクトン・ディキンソン・アンド・カンパニー 皮内空間への穿刺部材の穿通を強化するための方法及び装置
US6971999B2 (en) * 2001-11-14 2005-12-06 Medical Instill Technologies, Inc. Intradermal delivery device and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534881A (ja) * 2000-06-06 2003-11-25 ベクトン・ディキンソン・アンド・カンパニー 皮内空間への穿刺部材の穿通を強化するための方法及び装置
JP2002315741A (ja) * 2001-03-26 2002-10-29 Bayer Corp 穿刺装置用の加圧リング
US6971999B2 (en) * 2001-11-14 2005-12-06 Medical Instill Technologies, Inc. Intradermal delivery device and method

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016158756A1 (fr) * 2015-03-31 2016-10-06 テルモ株式会社 Formulation intradermique pour la médecine régénérative
JPWO2016158756A1 (ja) * 2015-03-31 2018-02-01 テルモ株式会社 再生医療用皮内投与製剤
EP3603731A4 (fr) * 2017-03-31 2020-07-15 Toppan Printing Co., Ltd. Dispositif d'administration percutanée
JPWO2020138193A1 (ja) * 2018-12-25 2021-02-18 国立大学法人弘前大学 薬剤投与デバイス、及び薬剤投与システム
JP7032745B2 (ja) 2018-12-25 2022-03-09 国立大学法人弘前大学 薬剤投与デバイス、及び薬剤投与システム
EP3903856A4 (fr) * 2018-12-25 2022-09-14 Hirosaki University Dispositif d'administration de médicament et système d'administration de médicament
WO2022030457A1 (fr) 2020-08-05 2022-02-10 株式会社ライトニックス Dispositif de dosage médical

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