WO2013003383A1 - Composés bicycliques pontés pour le traitement des infections bactériennes - Google Patents

Composés bicycliques pontés pour le traitement des infections bactériennes Download PDF

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Publication number
WO2013003383A1
WO2013003383A1 PCT/US2012/044267 US2012044267W WO2013003383A1 WO 2013003383 A1 WO2013003383 A1 WO 2013003383A1 US 2012044267 W US2012044267 W US 2012044267W WO 2013003383 A1 WO2013003383 A1 WO 2013003383A1
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Prior art keywords
octan
oxabicyclo
naphthyridin
methyl
pyrido
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PCT/US2012/044267
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English (en)
Inventor
Yasumichi Fukuda
David E. Kaelin Jr.
Sheo B. Singh
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Merck Sharp & Dohme Corp.
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Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd., Merck Sharp & Dohme Corp. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to JP2014518932A priority Critical patent/JP2014518267A/ja
Priority to US14/126,225 priority patent/US20140243302A1/en
Priority to CA2840060A priority patent/CA2840060A1/fr
Priority to EP12735698.8A priority patent/EP2723737A1/fr
Priority to AU2012275499A priority patent/AU2012275499A1/en
Publication of WO2013003383A1 publication Critical patent/WO2013003383A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present invention was made as a result of activities undertaken within the scope of joint research agreements between Merck & Co., Inc. and Kyorin Pharmaceutical Co., and between Merck & Co., Inc. and WuXi AppTec.
  • the present invention relates to novel bridged bicyclic compounds (including pharmaceutically acceptable salts, hydrates and prodrugs thereof), compositions containing such compounds, synthesis of such compounds, and use of such compounds as antibacterial agents.
  • novel compounds of this disclosure and compositions comprising such compounds are useful for treating bacterial infections and associated diseases and conditions.
  • Bacterial infection is a major healthcare problem, and the incidence of hospital- acquired bacterial diseases continues to rise, particularly with drug-resistant strains. See Chu et al., 1996, J. Med. Chem. 39:3853-3874.
  • many bacterial infections are either difficult to treat with today's antibiotics or even untreatable. This problem has become especially serious with the development of multiple drug resistance in certain strains of bacteria, such as Staphylococcus aureus, Streptococcus pneumoniae, Mycobacterium tuberculosis, Enterococcus sp. and Pseudomonas sp.
  • the appearance of vancomycin resistant Enterococcus has been particularly alarming because vancomycin was formerly the only effective antibiotic for treating this infection, and had been considered for many infections to be the drug of "last resort".
  • antibiotics that represent a new class of compounds not previously used to treat bacterial infection. Such compounds would be particularly useful in treating nosocomial infections in hospitals where the formation and transmission of resistant bacteria are becoming increasingly prevalent.
  • the present invention relates to bridged bicyclic compounds. These compounds, or pharmaceutically acceptable salts thereof, are useful in the treatment of bacterial infections caused by one or more of various pathogens including, but not limited to, Staphylococcus aureus.
  • the present invention includes a compound of Formula I:
  • n 1, 2, or 3;
  • n 0, 1, or 2;
  • Ro is H, (Ci_6)alkyl, acyl or sulfonyl
  • each Ri, R 2 , Ri', and R 2 ' is independently H, (Ci-6)alkyl, (Ci-6)hydroxyalkyl, - C0 2 R 3 , -CONR 4 R 5 , halogen, OR 3 , CF 3 , aryl, heteroaryl or NHR 4 ;
  • Ri is not OR 3 or NHR 4 when R 2 is OR 3 or NHR 4
  • Ri' is not OR 3 or NHR 4 when R 2 ' is OR 3 or NHR 4 ;
  • R 3 is H, (Ci_ 6 )alkyl, hydroxy(Ci_6)alkyl, or CF 3 ;
  • R 4 , R4' and R 5 are independently H, (Ci_6)alkyl, or CO 2 R 3 ;
  • Ari is a group having one of the following structures:
  • Z 2 , Z 5 and Z 6 are independently CRi b , or N;
  • Z 3 is C or N
  • Z3 is not N if the bond to which it is attached is a double bond;
  • Z 4 is CRiiaRiib, N, CRiia, NRna, or O;
  • Z 4 is not O, NR l la or CR l la Rnb if the :::::z bond to which it is attached is a double bond;
  • Xi i, Xi3, X 14 and X 16 are independently N or CRi a ;
  • Xi2 is CH, C-(Ci_ 6 )alkyl, C-(Ci_ 6 )alkoxy, C-halo, or C-COOH;
  • Xis is CH, C-(Ci_ 6 )alkyl or C-halo
  • R 6 is H; OH; NRi 3 Ri 4 ; (Ci_ 6 )alkyl; C(0)ORi 3 ; halo; CF 3 ; cyano ; allyloxy;
  • NRi 3 Ri 4 OH, CF 3 , COORi 4 , cyano, oxo, (Ci_6)alkyl or (Ci_6)alkoxy; S(0) 2 Ri3 optionally substituted wit yl; or
  • X is CRi c , O or S
  • each p and q is 0, 1, or 2, with the proviso that if X is O or S, both p and q cannot be 0;
  • each R 7 and Rs is independently H, halo, OH, (Ci_6)alkoxy, NRi 3 Ri 4 , CF 3 , or cyano;
  • R% is H, halo, OH, (Ci_ 6 )alkoxy, NH 2 , or cyano; Rgb is absent; and the ' ⁇ 1 ⁇ bond attached to Z 3 is a double bond; or
  • R a and R% together form oxo; and the ' ⁇ 11 ⁇ bond attached to Z 3 is a single bond; Rioa is H or (Ci_ 6 )alkyl; Ri 0 b is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond; or
  • Rioa and Riob together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; Riia is H or (Ci_6)alkyl; and Rub is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond or Z 4 is NR l la ; or
  • Riia and Rub together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; or Rioa and R l la together with the atoms to which they are attached form a 5- membered saturated, unsaturated or aromatic ring having 0 to 3 N and optionally substituted with a (Ci_ 6 )alkyl, wherein Ri 0 b and Rub are H or absent, depending on valence;
  • each Ri2, Ri 3 and Ri 4 is independently H or (Ci_ 6 )alkyl; each Ri5 is independently (Ci-C 6 )alkylene or (C2-C 6 )alkenylene with the proviso that when R 6 is -OR15COOR14, R15 is not C 2 alkenylene;
  • Ri a is H, OH, (Ci_6)alkoxy, cyano, or halo;
  • Ri b is H, (Ci_6)alkyl, (Ci_6)alkoxy, halo, cyano, or C(0)ORi3 ;
  • Ri c is H, halo or (Ci_ 6 )alkyl
  • aryl wherein aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents selected from OH, halo, (Ci_ 6 )alkoxy, halo(Ci_ 6 )alkoxy and (Ci_ 6 )alkyl;
  • heterocyclyl wherein the heterocyclyl is a 5- to 6-membered non-aromatic or aromatic ring having 1 or 2 heteroatoms selected from N, O or S optionally substituted with 1 to 3 substitutents selected from OH, halo, cyano, (Ci_ 6 )alkoxy, (Ci_ 6 )alkyl, NR13R14 and a 5- to 6- membered aromatic or non-aromatic ring having 1 or 2 heteroatoms selected from N, O or S; wherein (Ci_6)alkoxy or (Ci_6)alkyl optionally substituted with 1 or 2 halo; or
  • each Z 8 , Z 9 and Z w is independently CRi a or N;
  • Z11 and Zi 2 are each independently CRi a Ri b , NR 4 , O, or S;
  • Zi3 and Z14 are each independently CRi a or N;
  • Zis is CRi a or N;
  • Zig is CRi a Ri b Or NH
  • each Z 17 and Z 18 is independently NR 4 or O; each Ri6a and Ri 6b is independently H or CH 3 ;
  • Ri6a and Ri 6b together form oxo
  • each Ri 7a and R 17b is H;
  • Ri 8 is H or (Ci_ 6 )alkoxy
  • Ri is H or halo
  • each R 2 o, R21 and R22 is independently H or halo
  • n 1, 2, or 3;
  • n 0, 1, or 2;
  • Ro is H, (Ci_ 6 )alkyl, acyl or sulfonyl
  • each Rl, R2, Rl ', and R2' is independently H, (Ci-6)alkyl, (Ci-6)hydroxyalkyl, CO2R3, -CONR 4 R 5 , halogen, OR 3 , CF 3 , aryl, heteroaryl or NHR 4 ; with the proviso that Ri is not OR 3 or NHR 4 when R 2 is OR 3 or NHR 4 , and Ri' is not OR 3 or NHR 4 when R 2 ' is OR 3 or NHR 4 ;
  • R 3 is H, (Ci_ 6 )alkyl, hydroxy(Ci_6)alkyl, or CF 3 ;
  • R 4 , R 4 ' and R 5 are independently H, (Ci_ 6 )alkyl, or CO 2 R 3 ;
  • Ari is a group having one of the following structures:
  • Z 2 , Z 5 and Z 6 are independently CRib, or N;
  • Z 3 is C or N
  • Z3 is not N if the zi:::z bond to which it is attached is a double bond
  • Z 4 is CRiiaRiib, N, CRn a , R l la , or O;
  • Z 4 is not O, NR l la or CR lla Rnb if the ' ⁇ 11 ⁇ bond to which it is attached is a double bond;
  • X11, Xi3, X 14 and X 16 are independently N or CRi a ;
  • X12 is CH, C-(Ci_ 6 )alkyl, C-(Ci_ 6 )alkoxy, C-halo, or C-COOH;
  • Xis is CH, C-(Ci_ 6 )alkyl or C-halo
  • R 6 is H; OH; NR i3 Ri 4 ; (Ci_ 6 )alkyl; C(0)ORi 3 ; halo; CF 3 ; cyano ; allyloxy;
  • X is CRi c , O, S or S0 2 ;
  • R a is H, halo, OH, (Ci_6)alkoxy, NH 2 , or cyano; Rc>b is absent; and the ' ⁇ 1 ⁇ bond attached to Z3 is a double bond; or
  • R% and R% together form oxo; and the :::::z bond attached to Z 3 is a single bond;
  • Rioa is H or (Ci_ 6 )alkyl; Ri 0 b is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond; or
  • Rioa and Riob together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; Riia is H or (Ci_ 6 )alkyl; and Rub is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond or Z 4 is NRn a ; or
  • Riia and Rub together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; or Rioa and Rn a together with the atoms to which they are attached form a 5- membered saturated, unsaturated or aromatic ring having 0 to 3 N and optionally substituted with a (Ci_ 6 )alkyl, wherein Ri 0 b and Rub are H or absent, depending on valence;
  • each Ri 2 , R13 and Ri 4 is independently H, (Ci_6)alkyl, or (Ci_6)hydroxyalkyl; each Ri5 is independently (Ci-C6)alkylene or (C 2 -Ce)alkenylene with the proviso that when R 6 is -ORi 5 COORi 4 , R15 is not C 2 alkenylene;
  • Ria is H, OH, (Ci_ 6 )alkoxy, cyano, or halo;
  • Rib is H, (Ci_6)alkyl, (Ci_6)alkenyl, (Ci_6)alkoxy, halo, cyano, or C(0)ORi3 ;
  • Ric is H, OH, halo or (Ci_ 6 )alkyl
  • aryl wherein aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents selected from OH, halo, (Ci_ 6 )alkoxy, halo(Ci_ 6 )alkoxy and (Ci_ 6 )alkyl;
  • heterocyclyl wherein the heterocyclyl is a 5- to 6-membered non-aromatic or aromatic ring having 1 or 2 heteroatoms selected from N, O or S optionally substituted with 1 to 3 substitutents selected from OH, halo, cyano, (Ci_6)alkoxy, (Ci_6)alkyl, NRoRi 4 and a 5- to 6- membered aromatic or non-aromatic ring having 1 or 2 heteroatoms selected from N, O or S; wherein (Ci_ 6 )alkoxy or (Ci_ 6 )alkyl are optionally substituted with 1 or 2 halo; or
  • each Z 8 , Z 9 and Z 10 is independently CRi a , CRi b or N;
  • Zii and Z 12 are each independently CRi a Ri b , NR 4 , O, S0 2 or S;
  • Zi 3 and Z 14 are each independently CRi a or N;
  • Z 15 is CRi a or N
  • Zi 6 is CRi a Ri b or NH
  • each Zi 7 and Z 18 is independently NR 4 or O;
  • Zi is S0 2 ;
  • each Ri6a and Ri 6b is independently H or CH 3 ;
  • Ri6a and Ri 6b together form oxo
  • each Rn a and R 17b is H;
  • Ri 8 is H or (Ci_ 6 )alkoxy
  • Ri is H or halo
  • each R 2 o, R21 and R 22 is independently H or halo
  • compositions comprising the compounds of the invention, optionally in the presence of a second therapeutic agent.
  • aspects of the invention relate to methods of preparing a compound of the invention, to methods of preparing compositions of the invention, to methods of treating bacterial infection in patients using a compound of the invention, and to methods of controlling bacterial infection in patients using a compound of the invention.
  • the present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, as defined above and a first embodiment of the invention. Different embodiments further describing Formula (I) variables are described below.
  • the present invention relates to compounds of Formula (la) and pharmaceutically acceptable salts thereof
  • n 0 or 1 ;
  • each Ri and R 2 is independently H, halo, (C 1-6 )alkyl, OR 3 , or NHR 4 , wherein no more than one of Ri or R 2 on the same carbon is OR 3 or NHR 4;
  • R 3 is H or (Ci_ 6 )alkyl; Ari is a group having one of the following structures:
  • n 1, 2, or 3;
  • n 0, 1, or 2;
  • Ro is H, (Ci_ 6 )alkyl, acyl or sulfonyl
  • each RI, R2, RI ', and R2' is independently H, (Ci- 6 )alkyl, (Ci- 6 )hydroxyalkyl, - CO2R3, -CONR4R5, halogen, OR 3 , CF 3 , aryl, heteroaryl or NHR 4 ;
  • Ri is not OR 3 or NHR 4 when R 2 is OR 3 or NHR 4
  • Ri' is not OR 3 or NHR 4 when R 2 ' is OR 3 or NHR 4 ;
  • R 3 is H, (Ci_6)alkyl, hydroxy(Ci_6)alkyl, or CF 3 ;
  • R 4 , R4' and R 5 are independently H, (Ci_ 6 )alkyl, or C0 2 R 3 ;
  • Ari is a group having one of the following structures:
  • Z 2 , Z 5 and Z 6 are independently CRib, or N;
  • Z 3 is C or N
  • Z3 is not N if the zi:::z bond to which it is attached is a double bond
  • Z 4 is CRiiaRiib, N, CRn a , R l la , or O;
  • Z 4 is not O, NR l la or CR lla Rnb if the ' ⁇ 11 ⁇ bond to which it is attached is a double bond;
  • X11, Xi3, X 14 and X 16 are independently N or CRi a ;
  • X12 is CH, C-(Ci_ 6 )alkyl, C-(Ci_ 6 )alkoxy, C-halo, or C-COOH;
  • Xis is CH, C-(Ci_ 6 )alkyl or C-halo
  • R 6 is H; OH; NR i3 Ri 4 ; (Ci_ 6 )alkyl; C(0)ORi 3 ; halo; CF 3 ; cyano ; allyloxy;
  • X is CRi c , O, S or S0 2 ;
  • R a is H, halo, OH, (Ci_6)alkoxy, NH 2 , or cyano; Rc>b is absent; and the ' ⁇ 1 ⁇ bond attached to Z3 is a double bond; or
  • R% and R% together form oxo; and the :::::z bond attached to Z 3 is a single bond;
  • Rioa is H or (Ci_ 6 )alkyl; Ri 0 b is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond; or
  • Rioa and Riob together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; Riia is H or (Ci_ 6 )alkyl; and Rub is absent; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a double bond or Z 4 is NRn a ; or
  • Riia and Rub together form oxo; and the ' ⁇ 1 ⁇ bond attached to Z 4 is a single bond; or Rioa and Rn a together with the atoms to which they are attached form a 5- membered saturated, unsaturated or aromatic ring having 0 to 3 N and optionally substituted with a (Ci_ 6 )alkyl, wherein Ri 0 b and Rub are H or absent, depending on valence;
  • each Ri 2 , R13 and Ri 4 is independently H, (Ci_6)alkyl, or (Ci_6)hydroxyalkyl; each Ri5 is independently (Ci-C6)alkylene or (C 2 -Ce)alkenylene with the proviso that when R 6 is -ORi 5 COORi 4 , R15 is not C 2 alkenylene;
  • Ria is H, OH, (Ci_ 6 )alkoxy, cyano, or halo;
  • Rib is H, (Ci_6)alkyl, (Ci_6)alkenyl, (Ci_6)alkoxy, halo, cyano, or C(0)ORi3 ;
  • Ric is H, OH, halo or (Ci_ 6 )alkyl
  • aryl wherein aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents selected from OH, halo, (Ci_ 6 )alkoxy, halo(Ci_ 6 )alkoxy and (Ci_ 6 )alkyl;
  • heterocyclyl wherein the heterocyclyl is a 5- to 6-membered non-aromatic or aromatic ring having 1 or 2 heteroatoms selected from N, O or S optionally substituted with 1 to 3 substitutents selected from OH, halo, cyano, (Ci_6)alkoxy, (Ci_6)alkyl, NRoRi 4 and a 5- to 6- membered aromatic or non-aromatic ring having 1 or 2 heteroatoms selected from N, O or S; wherein (Ci_ 6 )alkoxy or (Ci_ 6 )alkyl are optionally substituted with 1 or 2 halo; or
  • each Z 8 , Z 9 and Z 10 is independently CRi a , CRi b or N;
  • Zii and Z 12 are each independently CRi a Ri b , NR 4 , O, S0 2 or S;
  • Zi 3 and Z 14 are each independently CRi a or N;
  • Z 15 is CRi a or N
  • Zi 6 is CRi a Ri b or NH
  • each Zi 7 and Z 18 is independently NR 4 or O;
  • Zi is S0 2 ;
  • each Ri 6a and Ri 6b is independently H or CH 3 ;
  • Ri 6a and Ri 6b together form oxo
  • each Ri 7a and Ri 7b is H;
  • Ri 8 is H or (Ci_ 6 )alkoxy
  • Ri is H or halo
  • each R 2 o, R21 and R 22 is independently H or halo
  • Xi is CH 2 , O, or NRo
  • n 0 or 1 ;
  • each Ri and R 2 is independently H, halo, (C 1-6 )alkyl, OR 3 , or NHR 4 , wherein only one of Ri or R 2 on the same carbon is OR 3 or NHR 4;
  • R 3 is H or (Ci_ 6 )alkyl
  • Ari is a group having one of the following structures:
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof, wherein
  • Xi is CH 2 or O
  • n 1;
  • each Ri and R 2 is independently H, (Ci_6)alkyl or OH, wherein no more than one of Ri or R 2 on the same carbon is OH ;
  • R 4 * is H or (Ci_ 6 )alkyl;
  • Ari is a group of the following structure:
  • Z 4 is CRiia or N
  • R 6 is OH; (Ci_6)alkyl; halo; CF 3 ; cyano ; (Ci_6)alkoxy, (C 3 _6)cycloalkoxy,
  • R a is H, F, CI, OH, (Ci_6)alkoxy, or cyano; Rc>b is absent; and the ' ⁇ 1 ⁇ bond attached to Z 3 is a double bond; or
  • R % and R % together form oxo; and the :::::z bond attached to Z 3 is a single bond;
  • Riia is H or (Ci_ 6 )alkyl
  • Ria is H, halo or (Ci_6)alkoxy
  • Rib is H, (Ci_ 6 )alkyl, halo, or (Ci_ 6 )alkoxy ;
  • Ar 2 is selected from
  • aryl wherein aryl is phenyl optionally substituted with 1 or 2 halo; or a group of the following structure:
  • Zio is CH or N
  • each Zii andZi 2 is CRi a Rib, N-(C 1-6 )alkyl, O or S;
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof,
  • Xi is CH 2 or O
  • Z is CH 2 ;
  • Ari is a group having one of the following structures:
  • Z 2 is CRi b ;
  • R 6 is (Ci_6)alkyl, halo, cyano, or (Ci_6)alkoxy, (C 3 _6)cycloalkylalkoxy, or
  • R a is F, CI, OH, or cyano
  • Rib is H or (Ci_6)alkyl
  • Ar 2 is a group having one of the following structures:
  • Z 8 is CR ia ;
  • Ri a is H, halo or (Ci_6)alkoxy
  • Z 11 is O or S
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof,
  • Xi is CH 2 or O
  • n 1 ;
  • Ari is a group having one of the following structures:
  • Z 2 is CRi b ;
  • R 6 is (Ci_6)alkyl, halo, cyano, or (Ci_6)alkoxy, (C 3 _6)cycloalkylalkoxy, or (C 3 _6)heterocycloalkoxy which are optionally substituted with OH, COOR 14 , cyano, or oxo;
  • R a is H, F, CI, OH, or cyano
  • Rib is H, F, CI, or (Ci_ 6 )alkyl
  • Ar 2 is a group having one of the following structures:
  • Zs and Z 10 are independently CRi a or N;
  • Ria is H, F, CI, or (Ci_6)alkoxy
  • Z 11 is O or S; and the other variables are as provided for in any of the first through fourth embodiments.
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof, wherein W is -CH 2 -CHOH-, and the other variables are as provided for in any of the first through fifth embodiments.
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof, wherein Ar 2 is
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof, wherein
  • the present invention relates to compounds of Formula (I), (la), or (lb) and pharmaceutically acceptable salts thereof, wherein Xi is O and the other variables are as provided for in any of the first through eighth embodiments.
  • each R ls R 2 , Ri', and R 2 ' is independently H, OH, (Ci- 6 )alkyl,
  • Ari is , wherein Zi-
  • Ari is .
  • Ar 2 is .
  • the compound of the invention is selected from the exemplary species depicted in Examples 1 through 190 shown below
  • the compound of the invention is selected from the exemplary species depicted in Examples 194 through 319 provided below (including free base forms thereof and any pharmaceutically acceptable salts thereof).
  • the compound of the invention is selected from the group consisting of:
  • the compound of the invention is selected from the group consisting of:
  • composition comprising a compound of Formula (I) or (lb) and a carrier, adjuvant, or vehicle;
  • composition comprising a compound of Formula (I) or (lb) and a pharmaceutically acceptable carrier, adjuvant, or vehicle;
  • a pharmaceutical combination which is (1) a compound of Formula (I) or (lb) and (2) a second therapeutic agent, wherein the compound of Formula (I) or (lb) and the second therapeutic agent are each employed in an amount that renders the combination effective for treating bacterial infections;
  • a method of treating bacterial infections in a subject in need thereof comprising administering to the subject a pharmaceutical composition of (b), (c), (d), or (e) or the combination of (f), (g) or (h).
  • the present invention also includes a compound of the present invention (i) for use in, (ii) for use as a medicine or medicament for, or (iii) for use in the preparation of a medicament for: treating bacterial infections.
  • the compounds of the present invention can optionally be employed in combination, either sequentially or concurrently, with one or more therapeutic agents effective against bacterial infections.
  • each embodiment may be combined with one or more other embodiments, to the extent that such a combination provides a stable compound and is consistent with the description of the embodiments. It is further to be understood that the embodiments of compositions and methods provided as (a) through (m) herein are understood to include all embodiments of the compounds, including such embodiments as result from combinations of embodiments of the compound.
  • Additional embodiments of the invention include the pharmaceutical compositions, combinations and methods set forth in (a)-(m) herein and the uses set forth in the preceding paragraph, wherein the compound of the present invention employed therein is a compound of one of the embodiments or aspects of the compounds described herein.
  • the compound may optionally be used in the form of a pharmaceutically acceptable salt or hydrate when appropriate.
  • the atoms may exhibit their natural isotopic abundances, or one or more of the atoms may be artificially enriched in a particular isotope having the same atomic number, but an atomic mass or mass number different from the atomic mass or mass number predominantly found in nature.
  • the present invention is meant to include all suitable isotopic variations of the compounds of generic Formula I or (lb).
  • isotopic forms of hydrogen include protium ( 1 H) and deuterium ( 2 H).
  • Protium is the predominant hydrogen isotope found in nature. Enriching for deuterium may afford certain therapeutic advantages, such as increasing in vivo half-life or reducing dosage requirements, or may provide a compound useful as a standard for characterization of biological samples.
  • Isotopically-enriched compounds within generic Formula I or (lb) can be prepared without undue experimentation by conventional techniques well known to those skilled in the art or by processes analogous to those described in the Schemes and Examples herein using appropriate isotopically-enriched reagents and/or intermediates.
  • the present compounds have antimicrobial (e.g., antibacterial) activities and are useful for the treatment of bacterial infections.
  • antimicrobial e.g., antibacterial
  • bacterial infection includes bacterial infections that occur in mammals as well as disorders related to bacterial infections that may be treated by administering antibiotics such as the compounds of the present invention.
  • Such bacterial infections and disorders related to such infections include one or more of the following: pneumonia, otitis media, sinusitus, bronchitis, tonsillitis, and mastoiditis related to infection by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhal ⁇ , Staphylococcus aureus, or Peptostreptococcus spp.; pharynigitis, rheumatic fever, and glomerulonephritis related to infection by Streptococcus pyogenes, Groups C and G streptococci, Clostridium diptheriae, or Actinobacillus haemolyticum; respiratory tract infections related to infection by Mycoplasma pneumoniae, Legionella pneumophila, Streptococcus pneumoniae, Haemophilus influenzae, or Chlamydia pneumoniae; uncomplicated skin and soft tissue infections, abscesses and osteomyelitis, and puerperal fever related to infection by
  • Staphylococcus aureus coagulase-positive staphylococci (i.e., S. epidermidis, S. hemolyticus, etc.), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcal groups C-F (minute- colony streptococci), viridans streptococci, Corynebacterium minutissimum, Clostridium spp., or Bartonella henselae; uncomplicated acute urinary tract infections related to infection by
  • Staphylococcus saprophyticus or Enterococcus spp. Staphylococcus saprophyticus or Enterococcus spp.; urethritis and cervicitis; and sexually transmitted diseases related to infection by Chlamydia trachormatis, Haemophilus ducreyi,
  • pyogenes H. influenza, or Listeria spp.
  • disseminated Mycobacterium avium complex (MAC) disease related to infection by Mycobacterium avium, or Mycobacterium intracellulare MAC
  • gastroenteritis related to infection by Campylobacter jejuni
  • intestinal protozoa related to infection by Cryptosporidium spp.
  • odontogenic infection related to infection by viridans streptococci
  • persistent cough related to infection by Bordetella pertussis
  • gas gangrene related to infection by Clostridium perfringens or Bacteroides spp.
  • atherosclerosis related to infection by Helicobacter pylori or Chlamydia pneumoniae.
  • Bacterial infections and disorders related to such infections that may be treated or prevented in animals include one or more of the following: bovine respiratory disease related to infection by P. haem., P. multocida, Mycoplasma bovis, or Bordetella spp.; cow enteric disease related to infection by E. coli; dairy cow mastitis related to infection by S.
  • aureus Streptococcus uberis, Streptococcus agalactiae, Streptococcus dysgalactiae, Klebsiella spp., Corynebacterium spp., or Enterococcus spp.; swine respiratory disease related to infection by Actinobacillus pleurpneumoniae, Pasteurella multocida, or Mycoplasma spp.; swine enteric disease related to infection by E. coli, Lawsonia intracellularis, Salmonella, or Serpulina hyodyisinteriae; cow footrot related to infection by Fusobacterium spp.; cow metritis related to infection by E.
  • multocida and dental or mouth infections in dogs and oats related to infection by Alcaligenes spp., Bacteroides spp., Clostridium spp., Enterobacter spp., Eubacterium, Peptostreptococcus, Porphfyromonas, or Prevotella.
  • the bacterial infections and disorders related to such infections includes one or more of the following: Staphylococcus aureus Smith, Enterococcus faecium A2373, Streptococcus pneumoniae IID554, and Escherichia coli ATCC 25922.
  • carbapenems that may be co-administered with the compounds of the invention include, but are not limited to, imipenem, meropenem, biapenem, (4R,5S,6S)-3- [3S,5S)-5-(3-carboxyphenyl-carbamoyl)pyrrolidin-3-ylthio]-6-(lR)-l-hydroxyethyl]-4-met ⁇ oxo-l-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (ertapenem), (lS,5R,6S)-2-(4-(2- (((carbamoylmethyl)-l,4-diazoniabicyclo[2.2.2]oct-l-yl)-ethyl (l,8-naphthosultam)methyl)-6- [l(R)-hydroxyethyl]-l-methylcarbapen-2-em-3-carboxylate chlor
  • penicillins suitable for co-administration with the compounds according to the invention include benzylpenicillin, phenoxymethylpenicillin, carbenicillin, azidocillin, propicillin, ampicillin, amoxycillin, epicillin, ticarcillin, cyclacillin, pirbenicillin, azloccillin, mezlocillin, sulbenicillin, piperacillin, and other known penicillins.
  • the penicillins may be used in the form of pro-drugs thereof; for example as in vivo hydrolysable esters, for example, the acetoxymethyl, pivaloyloxymethyl, a-ethoxycarbonyloxy-ethyl and phthalidyl esters of ampicillin, benzylpenicillin and amoxycillin; as aldehyde or ketone adducts of penicillins containing a 6-a-aminoacetamido side chain (for example hetacillin, metampicillin and analogous derivatives of amoxycillin); and as a-esters of carbenicillin and ticarcillin, for example the phenyl and indanyl a-esters.
  • in vivo hydrolysable esters for example, the acetoxymethyl, pivaloyloxymethyl, a-ethoxycarbonyloxy-ethyl and phthalidyl esters of ampicillin, benzylpenicillin and amoxy
  • cephalosporins examples include, cefatrizine, cephaloridine, cephalothin, cefazolin, cephalexin, cephacetrile, cephapirin, cephamandole nafate, cephradine, 4-hydroxycephalexin, cephaloglycin, cefoperazone, cefsulodin, ceftazidime, cefuroxime, cefmetazole, cefotaxime, ceftriaxone, and other known cephalosporins, all of which may be used in the form of pro-drugs thereof.
  • Examples of ⁇ -lactam antibiotics other than penicillins and cephalosporins that may be co-administered with the compounds according to the invention include aztreonam, latamoxef (MOXALACTAM), and other known ⁇ -lactam antibiotics such as serine ⁇ -lactamase inhibitors including, but are not limited to, clavulanic acid, sulbactam or tazobactam.
  • a dehydropeptidase (DHP) inhibitor may also be combined.
  • DHP dehydropeptidase
  • Many carbapenems are susceptible to attack by a renal enzyme known as DHP.
  • DHP dimethylcyclopropanecarboxamide-2-heptenoic acid or a useful salt thereof.
  • acyl refers to a carbonyl containing substituent represented by the formula -C(0)-R in which R is H, alkyl, a cycloalkyl, an aryl, a heterocycle, cycloalkyl- or aryl-substituted alkyl or heterocycle-substituted alkyl wherein the alkyl, alkoxy, cycloalkyl, aryl and heterocycle are as defined herein.
  • Representative acyl groups include, but are not limited to, alkanoyl (e.g. acetyl), aroyl (e.g. benzoyl), and heteroaroyl.
  • sulfonyl refers to a substituent represented by the formula -S(0) 2 -R in which R is H, alkyl, a cycloalkyl, an aryl, a heterocycle, cycloalkyl- or aryl- substituted alkyl or heterocycle-substituted alkyl wherein the alkyl, alkoxy, cycloalkyl, aryl and heterocycle are as defined herein.
  • alkenyl refers to a straight or branched-chain acyclic unsaturated hydrocarbon having a number of carbon atoms in the specified range and containing at least one double bond.
  • C 2 -C 3 alkenyl refers to vinyl, (lZ)-l-propenyl, (1 E)- 1 -propenyl, 2-propenyl, or isopropenyl.
  • alkoxy refers to an alkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
  • Representative examples of alkoxy include, but are not limited to, methoxy, ethoxy, propoxy, 2-propoxy, butoxy, tert-butoxy, pentyloxy, and hexyloxy.
  • alkyl refers to any linear or branched chain alkyl group having a number of carbon atoms in the specified range, for example 1-8, 1-6 or 1-4.
  • Ci_ 6 alkyl refers to all of the hexyl alkyl and pentyl alkyl isomers as well as n-, iso-, sec- and t-butyl, n- and isopropyl, ethyl and methyl.
  • Ci_ 6 alkyl and Ci_ 4 alkyl are examples of lower alkyls.
  • aryl refers to a mono-or bicyclic carbocyclic ring system having one or two aromatic rings.
  • exemplary aryls include, but are not limited to, phenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl and the like.
  • Aryl groups can be unsubstituted (unless otherwise indicated, such groups are unsubstituted) or substituted with one, two or three substituents independently selected from lower alkyl, substituted lower alkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, acylamino, cyano, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl and carboxamide.
  • cycloalkylalkoxy refers to a cycloalkyl group, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein.
  • the cycloalkyl group may have one or more carbon atoms in common with the alkoxy group.
  • a (C 3 _6)cycloalkylalkoxy refers to a C 3 -6 cycloalkyl group attached to an alkoxy group.
  • cycloalkylalkoxy examples include 2-(l -ethyl cyclopropyl)methoxy, 2-(l- propylcyclopropoxy), 2-(2-ethylcyclopropoxy), 2-(3-ethylcyclohexyl)methoxy, 2-(4- ethylcyclohexyl)methoxy, 2-(4-propylcyclohexyl)methoxy, 2-(2-(4-propylcyclohexyl)ethoxy), 2- (2-ethylcyclopentyl)methoxy, and 2-(2-propylcyclopentyloxy)pyridine.
  • cycloalkoxy or "cycloalkyloxy” refers to a cycloalkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
  • cycloalkyloxy include, but are not limited to, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, cycloheptyloxy, and cyclooctyloxy.
  • cycloalkyl refers to any cyclic ring of an alkane having a number of carbon atoms in the specified range.
  • C 3 _ 6 cycloalkyl refers to cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
  • halogen refers to fluorine, chlorine, bromine and iodine (alternatively referred to as fluoro, chloro, bromo, and iodo).
  • heteroaryl refers to a cyclic aromatic radical having from five to ten ring atoms of which one ring atom is selected from S, O and N; zero, one or two ring atoms are additional heteroatoms independently selected from S, O and N; and the remaining ring atoms are carbon, the radical being joined to the rest of the molecule via any of the ring atoms.
  • heteroaryls include, but are not limited to, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isooxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, furanyl, quinolinyl, isoquinolinyl, and the like.
  • Heteroaryl groups can be unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, substituted lower alkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, acylamino, cyano, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl and carboxamide.
  • heterocycle (and variations thereof such as “heterocyclic” or
  • heterocyclyl as used herein, broadly refers to (i) a stable 4- to 8-membered, saturated or unsaturated monocyclic ring, and the ring system contains one or more heteroatoms (e.g., from 1 to 6 heteroatoms, or from 1 to 4 heteroatoms) selected from N, O and S and a balance of carbon atoms (the monocyclic ring typically contains at least one carbon atom and the ring systems typically contain at least two carbon atoms); and wherein any one or more of the nitrogen and sulfur heteroatoms is optionally oxidized, and any one or more of the nitrogen heteroatoms is optionally quaternized.
  • heteroatoms e.g., from 1 to 6 heteroatoms, or from 1 to 4 heteroatoms
  • heterocyclic ring may be attached at any heteroatom or carbon atom, provided that attachment results in the creation of a stable structure.
  • Heterocycle groups can be unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, substituted lower alkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, acylamino, cyano, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl and carboxamide.
  • substituents may be attached to any atom in the ring, whether a heteroatom or a carbon atom, provided that a stable chemical structure results.
  • heterocycloalkoxy means a heterocycle group, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein.
  • the heterocycle group may have one or more carbon atoms in common with the alkoxy group.
  • a (C3_6)heterocycloalkoxy refers to a C 3 _ 6 heterocycle group attached to an alkoxy group.
  • heterocycloalkoxy include, but are not limited to, 2-(5- ethyltetrahydro-2H-pyran-2-yl)methoxy), 2-pyridin-3-ylethoxy, 3-quinolin-3-ylpropoxy, and 5- pyridin-4-ylpentyloxy.
  • heterocycleoxy means a heterocycle group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
  • Representative examples of heterocycleoxy include, but are not limited to, pyridin-3-yloxy and quinolin-3-yloxy.
  • substituents as used herein, means optional substitution with 1, 2 or 3 substituents, where the 1, 2 or 3 substitutents may be the same or different, or two may be the same and one may be different. Where the substituents are selected from categories of substituents, the 1, 2 or 3 substitutents may be selected from the same or different categories, or two may be selected from the same category and one may be selected from a different category.
  • heterocyclic ring described as containing from “1 to 4 heteroatoms” is intended to include as aspects thereof, heterocyclic rings containing 2 to 4 heteroatoms, 3 or 4 heteroatoms, 1 to 3 heteroatoms, 2 or 3 heteroatoms, 1 or 2 heteroatoms, 1 heteroatom, 2 heteroatoms, and so forth.
  • any of the various cycloalkyl and heterocyclic/heteroaryl rings and ring systems defined herein may be attached to the rest of the compound at any ring atom (i.e., any carbon atom or any heteroatom) provided that a stable compound results.
  • Suitable 5- or 6-membered heteroaromatic rings include, but are not limited to, pyridyl, pyrrolyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, thienyl, furanyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isooxazolyl, oxadiazolyl, oxatriazolyl, thiazolyl, isothiazolyl, and thiadiazolyl.
  • Suitable 9- or 10- membered heteroaryl rings include, but are not limited to, quinolinyl, isoquinolinyl, indolyl, indazolyl, benzimidazolyl, benztriazoyl, imidazopyridinyl, triazolopyridinyl, and
  • Suitable 4- to 6-membered heterocyclyls include, but are not limited to, azetidinyl, piperidinyl, morpholinyl, thiomorpholinyl, thiazolidinyl, isothiazolidinyl,
  • oxazolidinyl isoxazolidinyl, pyrrolidinyl, imidazolidinyl, piperazinyl, tetrahydrofuranyl, tetrahydrothienyl, pyrazolidinyl, hexahydropyrimidinyl, thiazinanyl, thiadiazinanyl,
  • a “stable” compound is a compound which can be prepared and isolated and whose structure and properties remain or can be caused to remain essentially unchanged for a period of time sufficient to allow use of the compound for the purposes described herein (e.g., therapeutic or prophylactic administration to a subject).
  • Reference to a compound also includes stable complexes of the compound such as a stable hydrate.
  • substituted and “optionally substituted” include mono- and poly- substitution by a named substituent to the extent such single and multiple substitution (including multiple substitution at the same site) is chemically allowed. Hence, the terms specifically contemplate one or more substitutions. Unless expressly stated to the contrary, substitution by a named substituent is permitted on any atom in a ring (e.g., an aryl, a cycloalkyl, a heteroaryl, or a heterocyclyl) provided such ring substitution is chemically allowed and results in a stable compound.
  • a ring e.g., an aryl, a cycloalkyl, a heteroaryl, or a heterocyclyl
  • Compounds of the present invention may be administered in the form of
  • salts may, however, be useful in the preparation of the compounds according to the invention or of their pharmaceutically acceptable salts.
  • the compounds of the present invention may be conveniently isolated as trifluoroacetic acid salts (e.g. following HPLC purification). Conversion of the trifluoroacetic acid salts to other salts, including pharmaceutically acceptable salts, may be accomplished by a number of standard methods known in the art. For example, an appropriate ion exchange resin may be employed to generate the desired salt. Alternatively, conversion of a trifluoroacetic acid salt to the parent free amine may be accomplished by standard methods known in the art (e.g. neutralization with an appropriate inorganic base such as NaHCOs). Other desired amine salts may then be prepared in a conventional manner by reacting the free base with a suitable organic or inorganic acid.
  • Representative pharmaceutically acceptable quaternary ammonium salts include the following: hydrochloride, sulfate, phosphate, carbonate, acetate, tartrate, citrate, malate, succinate, lactate, stearate, fumarate, hippurate, maleate, gluconate, ascorbate, adipate, gluceptate, glutamate, glucoronate, propionate, benzoate, mesylate, tosylate, oleate, lactobionate, laurylsulfate, besylate, caprylate, isetionate, gentisate, malonate, napsylate, edisylate, pamoate, xinafoate, napadisylate, hydrobromide, nitrate, oxalate, cinnamate, mandelate, undecylenate, and camsylate.
  • suitable pharmaceutically acceptable salts thereof may include alkali metal salts, e.g., sodium or potassium salts; alkaline earth metal salts, e.g., calcium or magnesium salts; and salts formed with suitable organic ligands, e.g., quaternary ammonium salts.
  • the present invention includes within its scope prodrugs of the compounds of this invention.
  • prodrugs will be functional derivatives of the compounds of this invention which are readily convertible in vivo into the required compound.
  • the term “administering” shall encompass the treatment of the various conditions described with the compound specifically disclosed or with a compound which may not be specifically disclosed, but which converts to the specified compound in vivo after administration to the patient.
  • Conventional procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in "Design of Prodrugs," ed. H. Bundgaard, Elsevier, 1985, which is incorporated by reference herein in its entirety. Metabolites of these compounds include active species produced upon introduction of compounds of this invention into the biological milieu.
  • administration and variants thereof (e.g., “administering” a compound) in reference to a compound of the invention mean providing the compound or a prodrug of the compound to the subject in need of treatment.
  • a compound of the invention or a prodrug thereof is provided in combination with one or more other active agents (e.g., other antibacterial agents useful for treating bacterial infections)
  • “administration” and its variants are each understood to include concurrent and sequential provision of the compound or prodrug and other agents.
  • composition is intended to encompass a product comprising the specified ingredients, as well as any product which results, directly or indirectly, from combining the specified ingredients.
  • pharmaceutically acceptable it is meant that the ingredients of the pharmaceutical composition must be compatible with each other and not deleterious to the recipient thereof.
  • subject refers to an animal, preferably a mammal, most preferably a human, who has been the object of treatment, observation or experiment.
  • the term "effective amount” as used herein means that amount of active compound or pharmaceutical agent that elicits the biological or medicinal response in a tissue, system, animal or human that is being sought by a researcher, veterinarian, medical doctor or other clinician.
  • the effective amount is a "therapeutically effective amount” for the alleviation of the symptoms of the disease or condition being treated.
  • references to the amount of active ingredient are to the free acid or free base form of the compound.
  • the compounds of the present invention can be administered by means that produces contact of the active agent with the agent's site of action. They can be administered by conventional means available for use in conjunction with pharmaceuticals, either as individual therapeutic agents or in a combination of therapeutic agents. They can be administered alone, but typically are administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice.
  • the compounds of the invention can, for example, be administered by one or more of the following: orally, parenterally
  • Liquid preparations suitable for oral administration can be prepared according to techniques known in the art and can employ the usual media such as water, glycols, oils, alcohols and the like.
  • Solid preparations suitable for oral administration can be prepared according to techniques known in the art and can employ such solid excipients as starches, sugars, kaolin, lubricants, binders, disintegrating agents and the like.
  • Parenteral compositions can be prepared according to techniques known in the art and typically employ sterile water as a carrier and optionally other ingredients, such as a solubility aid.
  • Injectable solutions can be prepared according to methods known in the art wherein the carrier comprises a saline solution, a glucose solution or a solution containing a mixture of saline and glucose. Further description of methods suitable for use in preparing pharmaceutical compositions of the present invention and of ingredients suitable for use in said compositions is provided in Remington's Pharmaceutical Sciences, 20 th edition, edited by A. R. Gennaro, Mack Publishing Co., 2000.
  • the compounds of this invention can be administered, e.g., orally or intravenously, in a dosage range of, for example, 0.001 to 1000 mg/kg of mammal (e.g., human) body weight per day in a single dose or in divided doses.
  • a dosage range is 0.01 to 500 mg/kg body weight per day orally or intravenously in a single dose or in divided doses.
  • Another example of a dosage range is 0.1 to 100 mg/kg body weight per day orally or intravenously in single or divided doses.
  • compositions can be provided in the form of tablets or capsules containing, for example, 1.0 to 500 milligrams of the active ingredient, particularly 1, 5, 10, 15, 20, 25, 50, 75, 100, 150, 200, 250, 300, 400, and 500 milligrams of the active ingredient for the symptomatic adjustment of the dosage to the patient to be treated.
  • the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the host undergoing therapy.
  • the present invention also includes processes for making compounds of Formula (I).
  • the compounds of the present invention may be prepared according to the following reaction schemes and examples, using the appropriate intermediates and starting materials described in the Intermediates and Experimentals sections below, or modifications thereof.
  • LDA lithium diisopropylamide
  • the nitrogen protecting group can be removed using, in the case of Boc, HC1 or TFA to give III.
  • Combination of III with an appropriate aldehyde using conditions capable of reductive amination e.g. NaBH(OAc) 3 ) yields the final compound IV.
  • the hydroxyl group of compound II can be alkylated or acylated using conditions familiar to those skilled in the art to give V, which can be further transformed to desired products using the method described in Scheme 1 (Scheme 2).
  • R acyl, alkyl
  • an intermediate of the general structure III can be treated with either an alkyl or acyl chloride or an alkyl or aryl sulfonyl chloride in the presence of an appropriate base to give VI or VII, respectively (Scheme 3).
  • An alternate class of compounds can be prepared by reacting VIII with the appropriate aryl bromide in the presence of an appropriate palladium catalyst to give IX, which can be transformed into the final products by nitrogen deprotection followed by derivatization (Scheme 4).
  • An additional class of compounds can be prepared by reacting X with the appropriate aryl bromide in the presence of an appropriate palladium catalyst to give XI, which can be transformed into the final products by nitrogen deprotection followed by derivatization (Scheme 5).
  • An additional class of compounds can be prepared by reacting XII with the appropriate aryl bromide in the presence of an appropriate palladium catalyst to give XIII, which can be transformed into the final products by nitrogen deprotection followed by derivatization (Scheme 6). Compounds of the structure XIII can be transformed to the corresponding trans olefin by catalytic hydrogenation to give XIV.
  • An alternate class of compounds can be prepared starting from the appropriate aryl bromide Br-Ari by performing a halogen-metal exchange using, for example, n-BuLi followed by addition of XV to give XVI (Scheme 7).
  • a class of ether linked compounds can be prepared by reacting XVII with HO- Ari and an appropriate base to give XVIII.
  • the ester of XVIII can be converted to the corresponding amine using conditions familiar to those skilled in the art (saponification, followed by Curtius rearrangement) to give XIX (Scheme 8).
  • An additional class of compounds can be prepared by performing a reductive amination on XX using ammonia followed by protection of the resultant amine with, for example, CbzCl to give XXI (Scheme 9). Selective deprotection of Pi followed by
  • XX can be converted directly into final products.
  • An additional approach involves reacting the ketone of XX with hydroxylamine or an alkylhydroxylamine to give XXIII, which can be converted to final products using the methods described above.
  • a class of dihydroxy-containing compounds can be prepared from XXIV using, for example, osmium tetroxide, to give XXV, which can be further transformed as described above (Scheme 10).
  • triflate XXVIII can be used to alkylate HN- An (Scheme 12).
  • the antibacterial activity of the present compounds can be demonstrated by various assays known in the art, for example, by their minimum inhibitory concentration (MIC- 100) against bacteria and minimum effective concentration (MEC).
  • MIC- 100 minimum inhibitory concentration
  • MEC minimum effective concentration
  • Compounds provided in the Examples were generally found to inhibit the growth of S. aureus in the range of 0.015 to 64 ⁇ g/mL.
  • the potency of antibacterial agents was measured using the Minimal Inhibitory Concentration (MIC) assay.
  • the assay measures the ability of test agents to inhibit the growth of bacteria on agar-containing medium.
  • the bacterial test strains used were exemplified by Staphylococcus aureus Smith, Enterococcus faecium A2373, Streptococcus pneumoniae IID554, and Escherichia coli ATCC 25922. All strains were maintained as frozen stocks held at -80 °C in skim milk. Other bacterial test strains are well known to those skilled in the art and can be used for testing.
  • MHA BBL Becton Dickinson and Company, Sparks, MD
  • DHB defibrinated horse blood
  • MIC values were determined using a modified agar dilution procedure described by the Clinical and Laboratory Standards Institute (CLSI; Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard— Eighth Edition.
  • CLSI document M07-A8 [ISBN 1-56238-689-1]. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009).
  • test compounds Stock solutions (6.4 mg/mL) of test compounds were prepared in 100% ultrapure dimethyl sulfoxide (DMSO; source) on the day of the assay. Subsequent serial dilutions were performed to generate solutions with concentrations ranging from 6.4 to 0.0002 mg/mL in 100% DMSO.
  • DMSO ultrapure dimethyl sulfoxide
  • Agar medium containing test compound was prepared by adding the dilutions of antimicrobial solution to molten MHA at a temperature of 45 - 50°C. The agar and antimicrobial solution were mixed thoroughly, poured into petri dishes, and allowed to solidify at room temperature. The final concentration of test compounds in the MHA medium ranged from 128 to 0.001 ⁇ g/mL with two-fold dilutions. MHA plates lacking antibacterial compound were used for growth controls.
  • the bacterial isolates Prior to susceptibility testing, the bacterial isolates were removed from frozen storage, thawed at room temperature, sub-cultured to MHA medium and incubated overnight at 35°C. S. pneumoniae and E.faecium were subcultured on MHA supplemented with 5% DHB at 35°C with 5%. Colonies from each plate were suspended in normal saline. This suspension was adjusted to the turbidity of a 0.5 McFarland standard, 1 - 2 x 10 colony forming units (CFU) per mL, and diluted 100-fold to 1 - 2 x lO 6 CFU/mL.
  • CFU colony forming units
  • Suspensions of bacterial cultures were applied to the surface of MHA plates containing test compound as well as to a growth control plate lacking test compound using an inoculum-replicating device with 4 mm pins.
  • the replicating device applied 5 uL of the bacterial suspension such that each spot contained approx. 1 x 10 4 CFU. Plates were dried for about 40 min and incubated at 35°C for 16 - 20 hr prior to scoring. The MIC was recorded as the lowest concentration of test agent that completely inhibited growth.
  • S. aureus Smith and S. pneumoniae IID554 strains were susceptible to levofloxacin, vancomycin, and linezolid based on MIC interpretive standards defined by CLSI.
  • E.faecium A2373 was susceptible to linezolid but resistant to vancomycin.
  • E.coli ATCC 25922 and Pseudomonas aeruginosa PAOl were susceptible to levofloxacin and imipenem. All test agents demonstrated potent activity against S.aureus with MIC values ranging from 0.016 to 32 ⁇ g/mL. See Table 1. MIC results were slightly higher against E. coli ATCC 25922 (values ranged from 1 to >64 ⁇ g/mL, data not shown). Representative compounds, tested against multiple bacteria, demonstrated broad spectrum antibacterial activity. See Table 2.
  • Example Numbers correspond to the examples described in the Examples section.
  • LAHL1AIH4 Lithium aluminum hydride (LiAlH 4 )
  • a suspension of A.5 (2.73 g) in 6 N hydrochloric acid (39.3 mL) was heated under reflux for 5 hours, the mixture was concentrated in vacuo to give A.6 (2.67 g).
  • A.9 A To a solution of A.9 (2.00 g) in dimethyl sulfoxide (31 mL) was added 2- iodoxybenzoic acid (3.29 g) at room temperature, the resulting suspension was stirred at the same temperature for 1 hour. After dilution of the mixture with water, the mixture was extracted with ethyl acetate. The organic extracts were dried over anhydrous sodium sulfate, filtered, and then concentrated in vacuo. Flash chromatography (hexane : ethyl acetate 6: 1) of the residue gave A (1.81 g).
  • a solution of ethyl acrylate (215 mL) in anhydrous tetrahydrofuran (300 mL) was added to the suspension, the resulting mixture was stirred for 15 minutes.
  • the mixture was poured onto ice water, adjusted to pH 3 by addition of concentrated hydrochloric acid and extracted with ethyl acetate.

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Abstract

Cette invention concerne de nouveaux composés bicycliques pontés, ainsi que leurs sels de qualité pharmaceutique, hydrates et promédicaments. Des compositions contenant lesdits composés, des procédés de préparation desdits composés et des procédés pour les utiliser à titre d'agents antibactériens sont également décrits. Les composés décrits, leurs sels de qualité pharmaceutique, hydrates et promédicaments, ainsi que les compositions contenant lesdits composés, sels, hydrates et promédicaments, sont utiles pour traiter les infections bactériennes et autres maladies et affections associées.
PCT/US2012/044267 2011-06-27 2012-06-26 Composés bicycliques pontés pour le traitement des infections bactériennes WO2013003383A1 (fr)

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CA2840060A CA2840060A1 (fr) 2011-06-27 2012-06-26 Composes bicycliques pontes pour le traitement des infections bacteriennes
EP12735698.8A EP2723737A1 (fr) 2011-06-27 2012-06-26 Composés bicycliques pontés pour le traitement des infections bactériennes
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JP2015086180A (ja) * 2013-10-31 2015-05-07 日本化薬株式会社 １，５−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤
WO2015103509A1 (fr) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Dérivés de pyrrolidinyle sulfone et leur utilisation en tant que modulateurs de ror gamma
EP3050888A1 (fr) 2015-01-27 2016-08-03 Merck Sharp & Dohme Corp. Composés pour le traitement d'infections bactériennes
US9750748B2 (en) 2012-12-17 2017-09-05 Takeda Pharmaceutical Company Limited Pyridazinones as DAAO enzyme inhibitors
WO2017153235A1 (fr) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft N-cyclo-3-aryl-1-naphthamides substitués et leur utilisation
US9931340B2 (en) 2011-08-22 2018-04-03 Takeda Pharmaceutical Company Limited Pyridazinone compounds and their use as DAAO inhibitors
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US10202399B2 (en) 2011-11-15 2019-02-12 Takeda Pharmaceutical Company Limited Dihydroxy aromatic heterocyclic compound
WO2019241461A1 (fr) 2018-06-15 2019-12-19 Bristol-Myers Squibb Company Mimétiques de thiodisaccharides à base de tétrahydropyrane en tant qu'inhibiteurs de galectine-3
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US9931340B2 (en) 2011-08-22 2018-04-03 Takeda Pharmaceutical Company Limited Pyridazinone compounds and their use as DAAO inhibitors
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WO2015103509A1 (fr) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Dérivés de pyrrolidinyle sulfone et leur utilisation en tant que modulateurs de ror gamma
EP3050888A1 (fr) 2015-01-27 2016-08-03 Merck Sharp & Dohme Corp. Composés pour le traitement d'infections bactériennes
WO2016123146A1 (fr) 2015-01-27 2016-08-04 Merck Sharp & Dohme Corp. Composés pontés pour le traitement des infections bactériennes
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WO2019241461A1 (fr) 2018-06-15 2019-12-19 Bristol-Myers Squibb Company Mimétiques de thiodisaccharides à base de tétrahydropyrane en tant qu'inhibiteurs de galectine-3
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