WO2012169860A2 - 콩 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물 - Google Patents
콩 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물 Download PDFInfo
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- WO2012169860A2 WO2012169860A2 PCT/KR2012/004599 KR2012004599W WO2012169860A2 WO 2012169860 A2 WO2012169860 A2 WO 2012169860A2 KR 2012004599 W KR2012004599 W KR 2012004599W WO 2012169860 A2 WO2012169860 A2 WO 2012169860A2
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- composition
- hair
- extract
- beans
- alcohol
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- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Definitions
- Hair loss prevention or hair growth promoting composition comprising soy extract
- the present invention relates to a hair loss preventing or hair growth promoting composition comprising a soybean extract.
- Hair cycles can be roughly divided into three phases: growth, degeneration and rest.
- anagen is the period when active cell division occurs in the dermal papilla and the growth of new hair is promoted, and hair grows only during this period.
- Each hair has a growth period of about 3 to 5 years for males and 4 to 6 years for females. Thus, about 80 to 85% of hair corresponds to growth.
- Catagen is a period in which cell division gradually stops and takes about three to four weeks.
- talogen is the period when the hair papilla is atrophy and the hair is separated from the capillaries and simply embedded in the scalp. About three months and the hair at rest is easily pulled out by physical stimulation.
- the present invention aims to provide a composition for preventing hair loss or promoting hair growth and promoting hair health.
- One aspect of the present invention provides a composition for preventing hair loss or promoting hair growth comprising soybean extract extracted with d ⁇ C 5 alcohol of ⁇ to 70% (v / v) concentration as an active ingredient.
- Another aspect of the present invention provides a hair health promotion composition comprising a soybean extract extracted with C ⁇ C 5 alcohol at a concentration of 1% to 70% (v / v).
- Another aspect of the present invention provides a cosmetic, food or pharmaceutical composition comprising the composition.
- the composition according to the present invention includes a soybean extract extracted with lower alcohol, specifically, a lower concentration of lower alcohol as an active ingredient, thereby improving blood circulation of capillaries It nourishes epithelial cells of hair roots and stimulates hair roots to induce activation of dermal papilla cells. Therefore, it inhibits the progress of hair loss and at the same time promotes hair growth, and further prevents the aging of the hair and scalp, and is excellent in improving hair health. In addition, for each hair, it is excellent in promoting hair growth by promoting the transition from the resting phase to the growth phase.
- 1 is a picture showing the degree of hair growth of the mouse according to the application of the soybean extract.
- hair loss refers to a phenomenon in which hair falls off the scalp or a condition in which the hair is coarse or thin
- hair loss prevention means preventing and suppressing hair loss as described above.
- Promoting hair growth means not only promoting the production of new hair, but also keeping the existing hair healthy.
- Hair growth is affected by several factors, including environmental factors such as temperature or sunlight, the nutritional status and disease of the individual, hormones, delivery, and exposure to radiation or other drugs.
- the main causes of hair loss can be divided into physiological factors such as internal factors and external factors caused by the external environment.
- physiological factors such as internal factors and external factors caused by the external environment.
- Physiological aspects of the body include 5-alpha reductase, which increases the secretion of sebum by converting testosterone and testosterone, known as a type of androgen, into dihydrotestosterone (DHT).
- DHT dihydrotestosterone
- External factors caused by the external environment include lack of nutrients to the hair roots due to blood vessel atrophy caused by poor blood circulation and dry scalp.
- the blood vessels are expanded to nourish the hair root, or the ingredients that act the same as the hair constituents are directly supplied to the hair root, or a detergent or sebum secretion inhibitor is used.
- a detergent or sebum secretion inhibitor is used.
- Vitamin E, unsaturated fatty acids or anthocyanins contained in soybeans, such as black soybeans, are known to be able to dilate blood vessels and thus facilitate blood circulation. So far, research on soybeans has been mainly conducted in terms of how to isolate and purify the active ingredient exhibiting pharmacological activity. Very little research has been done on its use. Moreover, also in the extraction method, the extraction method using the high concentration organic solvent which is the extraction method normally used for natural water has been mainly used. In addition to the known ingredients, soy extract has several unknowns, some of which may have useful pharmacological effects on the human body. In addition, the useful component may not be extracted by a conventional extraction method using a high concentration organic solvent.
- the present inventors have taken the recognition of the extraction methods commonly used in natural product extraction, but obtained extracts from soybeans using low concentration organic solvents as extraction solvents, and this extract is more potent than hair extracts extracted with high concentration organic solvents. It has been found to have hair growth promoting and hair health promoting effects.
- one aspect of the present invention is a composition for hair comprising soybean extract extracted with d ⁇ C 5 alcohol at a concentration of ⁇ 70% (v / v) as an active ingredient, specifically a composition for preventing hair loss or promoting hair growth and hair health It provides a composition for promotion.
- the soybean extract has the effect of inducing the activation of the dermal papilla cells to promote proliferation and to expand the capillaries to activate the blood circulation to nourish the hair root. It also promotes transition to the growth phase for hair at rest. Therefore, the composition according to the present invention comprising it as an active ingredient may prevent hair loss, promote hair growth, further prevent hair aging, increase hair gloss, and strengthen hair root to enhance hair health.
- the composition is characterized in that it comprises a soybean extract extracted using a low concentration organic solvent as an active ingredient.
- the organic solvent includes CrC 5 alcohol.
- the d-Cs alcohol may be any one or two or more of a mixed solvent selected from the group consisting of methane, ethane, isopropyl alcohol, n-propyl alcohol n-butane and isobutanol, specifically Ethane may be, but is not limited thereto.
- the concentration of the d ⁇ C 5 alcohol is 1 to specifically 1 to
- the soybean includes all the soybean extract has the effect of preventing hair loss, promoting hair growth or promoting hair health.
- the soybean comprises black beans or colored beans.
- the soybean is frosted soybean, soybean, taetae, green soybeans (cheongtae), green beans, green beans, fence beans, green beans, red beans, And one or more selected from the group consisting of soybean sprouts, bean sprouts, sesame beans and soybeans.
- black bean is a generic term for beans whose color of the grain husk is black.
- Examples of the black soybeans include, but are not limited to, seo tae, seomok tae and talgo, etc.
- the name of black beans can be variously called by the influence of region, classification, and dialect.
- black bean extract refers to a material extracted from black beans through various extraction methods, and includes, for example, a material extracted using an organic solvent, various fractions of the extracted material, and the like. .
- the term "colored-bean” refers to a bean having a color of grainy color, and a bean having a color such as red, yellow, or blue as well as black.
- Comprehensive Examples of the colored beans may include, but are not limited to, Seoritae, Seomoktae, Hwagotae, Taegeuk, Green Daebean, River Kidney Beans, Stains Kidney Beans, Korean Beans, Mung Beans, Red Beans, Soybeans, Bean Sprouts, Sesame Beans, or Soybeans. It is not.
- the name of colored beans can be variously called by the influence of region, classification and dialect.
- the term "colored soybean extract” refers to a substance extracted from colored soybeans through various extraction methods, and includes, for example, a substance extracted using an organic solvent, various fractions of the extracted substance, and the like. do.
- composition according to one aspect of the present invention is 0.001 to 0.00 based on the total weight of the composition
- One aspect of the present invention provides a cosmetic composition
- a cosmetic composition comprising a composition comprising a soybean extract extracted with d ⁇ C 5 alcohol of 1% to 70% (v / v) " concentration.
- the cosmetic composition may be provided in any formulation suitable for topical application.
- it can be provided in the form of emulsions obtained by dispersing the oil phase in solution, aqueous phase, emulsions obtained by dispersing the aqueous phase in oil phase, suspensions, solids, gels, powders, pastes, foams or aerosol compositions.
- Compositions of such formulations may be prepared according to conventional methods in the art.
- the cosmetic composition may contain, in addition to the above-mentioned substances, other ingredients that can give a synergistic effect to the main effect within a range not impairing the main effect.
- Cosmetic composition according to the present invention is a vitamin, a polymer peptide, a polymer polysaccharide and It may comprise a material selected from the group consisting of pingo lipids.
- the cosmetic composition according to the present invention may include a moisturizer, an emulsifier, a surfactant, a UV absorber, a preservative, a disinfectant, an antioxidant, a pH adjuster, an organic and inorganic pigment, a perfume, a cooling agent, or a restricting agent. have.
- the blending amount of the above components can be easily selected by those skilled in the art within the range that does not impair the object and effect of the present invention, the blending amount may be 0.01 to 5% by weight, specifically 0.01 3% by weight based on the total weight of the composition have.
- One aspect of the present invention provides a food composition
- a food composition comprising a composition comprising a soy extract extracted with d ⁇ C 5 alcohol at a concentration of 1% to 70% (v / v).
- the formulation of the food composition is not particularly limited, but may be, for example, formulated into tablets, granules, drinks, caramel, and the like.
- the food composition of each formulation may be appropriately selected and blended by those skilled in the art according to the formulation or purpose of use, in addition to the active ingredients, and synergistic effects may occur when applied simultaneously with other ingredients. have.
- Dosage determination of the active ingredient is within the level of one skilled in the art, the daily dosage of which is for example from 0.1 mg / kg / day to 5000 mg / kg / day, more specifically from 50 mg / kg / day to It may be 500 mg / kg / day, but is not limited thereto and may vary depending on various factors such as the age, health condition, and complications of the subject to be administered.
- One aspect of the present invention provides a pharmaceutical composition
- a pharmaceutical composition comprising a composition comprising a soybean extract extracted with d ⁇ C 5 alcohol at a concentration of 1% to 70% (v / v).
- the pharmaceutical composition may exhibit an effect of preventing or treating hair loss, promoting hair growth, and promoting hair health.
- compositions according to one aspect of the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously.
- Formulations for oral administration may be tablets (! 3 ⁇ 4 ⁇ ), pills ' ( ⁇ ), soft and hard capsules, granules, powders, fines, liquids, emulsions or pellets. However, it is not limited thereto.
- Formulations for parenteral administration may include, but are not limited to, solutions, suspensions, emulsions, gels, injections, drops, suppositories, patches or sprays.
- the formulations can be easily prepared according to the conventional methods of the field, such as surfactants, excipients, hydrating agents, emulsifiers suspending agents, salts or buffers for controlling osmotic pressure, colorants, spices, stabilizers, preservatives, Preservatives or other commonly used auxiliaries can be used as appropriate.
- the active ingredient of the pharmaceutical composition according to one aspect of the present invention will vary depending on the age, sex, weight, pathology and severity of the subject to be administered, the route of administration or the judgment of the prescriber.
- Dosage determination based on these factors is within the level of ordinary skill in the art and its daily dosage may, for example, be from 0.1 mg / kg / day to 5000 mg / k g / day, more specifically from 50 mg / kg / day to 500 mg / kg. May be, but is not limited to.
- 300 g of dried kidney beans were immersed in 1.5 L of an aqueous solution of 20% (v / v) ethane at a temperature of 60 ° C., and refluxed for 3 hours, followed by standing at room temperature for a predetermined time.
- the extract was filtered, concentrated under reduced pressure, and lyophilized to prepare a powder sample. The yield was 3-15%, and the prepared powder was stored at low temperature until use.
- 300 g of the dried bean sprouts beans were immersed in 1.5 L of an ethanol solution of 20% (v / v) at a temperature of 60 ° C., and refluxed for 3 hours, followed by standing at room temperature for a predetermined time.
- the extract was filtered, concentrated under reduced pressure, and lyophilized to prepare a powder sample. The yield was 3 ⁇ 15%, and the prepared powder was stored at low temperature until use.
- Example 18 Preparation of Fence Bean Butane Extract 25 g of 20% (v / v) ethane obtained in Example 11 was dissolved in 250 ml of distilled water, and then extracted with 250 ml of n-butane twice using a separatory funnel. The obtained butanol layer was concentrated under reduced pressure. After freeze drying to prepare a sample. The yield was 5 ⁇ 15%, and the prepared samples were kept until use.
- Example 8 The 20% (v / v) ethane obtained in Example 8 was dissolved in bean sprout bean extract lg in 10 ml of distilled water, and extracted twice with 10 ml of n-butanol using a separatory funnel. Dried to prepare a sample. The yield was 5-15%, and the prepared samples were stored at low temperature until use.
- Example 12 25 g of the 20% (v / v) ethanol soybean extract obtained in Example 12 was dissolved in 250 mi of distilled water, and extracted twice with 250 ml of n-butane using a separatory funnel, followed by concentration under reduced pressure, followed by freeze drying. To prepare a sample. The yield was 5 ⁇ 153 ⁇ 4, and the prepared samples were stored at low temperature until use.
- Example 6 20% (v / v) ethane obtained in Example 6 was dissolved in 10 ml of kidney bean extract lg in distilled water, and then extracted with n-butane to 10 ml twice using a separatory funnel. Concentrated under reduced pressure and freeze-dried to prepare a sample. The yield was 5 ⁇ 15%, and the prepared sample was stored at low temperature until use.
- the frost extract was obtained in substantially the same manner as in Comparative Example 2. The yield was 7-20%, and the prepared powder was stored at low temperature until use.
- DP cells were first prepared in 96-well plates at a concentration of about 10 4 cells / well per well.
- Examples 1 to 4 and Examples 1 to 3 were dissolved in DMSCKDimethyl sulfoxide or ethane, respectively, and then serial dilution was performed with DMEM medium having a 5% FBS serum concentration so that the final concentration was lOppm. .
- DMEM medium having a 5% FBS serum concentration so that the final concentration was lOppm.
- DMEM medium having a 5% FBS serum concentration
- MT solution prepared at a concentration of 2 mg /, one for each well After addition, it was left for 4 hours in the same incubator. If the MTT reagent is determined to be absorbed by intracellular mitochondria, remove the supernatant, add DMS0,
- Examples 1-4 dermal papilla cell growth promoting effect was better.
- the soybean papilla cell proliferation promoting effect of Example 2 which is a soybean extract extracted with 20% ethanol, was the best. Therefore, it can be seen that the soybean extract extracted with alcohol has an excellent effect of promoting hair papilla cell proliferation, preventing hair loss, promoting hair growth, and further promoting hair health.
- Examples 1 to 4 and Comparative Example 1 and 3 added to the medium production method is the same as in Test Example 1.
- DMEM containing 10% FCS was added, cells were taken, and placed in EP tubes and centrifuged at 6000 rpm. The supernatant was removed, the remaining cell solution was suspended in PBS, and cell counts were measured using a hemocytometer. Based on this, the capillary expandability of Examples 4 and Comparative Examples 1 and 3 was calculated. It is shown in the table below.
- Example 2 which is a soybean extract extracted with 20% ethanol was the best. Therefore, Alcolo extract can be seen that the soybean extract has an excellent effect on improving the blood circulation of the scalp capillaries, promoting hair health, inhibiting the progression of hair loss, and promoting hair growth.
- Example 2 and 4 were used to evaluate the hair growth promoting effect of the mouse.
- the dorsal hair of 47 53 day old mice (C57BL / 6) was removed with an electric clipper.
- Mouse hair of this age is characterized in that it does not grow immediately because it is in the resting phase.
- the mice with good back skin were selected and divided into three groups to include 5-7 mice per group, and then reared in a separate case.
- the group that consumed cereal feed containing no soy extract was used as a control.
- changes in the hair removal site of each group were observed, and a photograph thereof is shown in FIG. 1.
- the hair of each newly grown mouse at the epilation site was collected by an electric clipper and weighed. The results are shown in the table below.
- the soybean extract extracted with ethanol promoted the growth of mouse hair. This can also be seen in the appearance shown in Figure 1 and the hair weight of Table 3.
- the soybean extract extracted with 2 ethanol was very effective in promoting hair growth. Therefore, it can be seen that the soybean extract extracted with alcohol has an excellent hair growth promoting effect.
- soybean extract 100 mg of soybean extract, 50 mg of soy extract, 180 mg of soybean oil, 2 mg of palm oil, 8 mg of palm oil oil, 4 mg of lead wax and 6 mg of lecithin were mixed and layered 400 mg per 1 capsule according to a conventional method.
- a soft accelerator is prepared.
- Seomoktae extract 100 mg of Seomoktae extract, 10 g of glucose, 2 g of citric acid and 187.8 g of purified water are mixed and layered in a bottle.
- the final dose of the contents is 200 ml.
- composition ratio of the above-mentioned vitamin and mineral mixtures is a composition that is relatively suitable for health foods, but may be modified arbitrarily, and the above ingredients may be mixed according to a conventional health food manufacturing method.
- the granules may be prepared and used for preparing a health food composition according to a conventional method.
- Cream is prepared in a conventional manner according to the composition described in the table below.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
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- Nutrition Science (AREA)
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Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201280038928.8A CN103702660A (zh) | 2011-06-09 | 2012-06-11 | 用于预防脱发或促进毛发修复的含有豆提取物的组合物 |
US14/124,602 US9572765B2 (en) | 2011-06-09 | 2012-06-11 | Composition for preventing hair loss or promoting hair restoration, comprising soy extract |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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KR1020110055597A KR20120136581A (ko) | 2011-06-09 | 2011-06-09 | 콩 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물 |
KR10-2011-0055597 | 2011-06-09 |
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WO2012169860A2 true WO2012169860A2 (ko) | 2012-12-13 |
WO2012169860A3 WO2012169860A3 (ko) | 2013-03-07 |
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PCT/KR2012/004599 WO2012169860A2 (ko) | 2011-06-09 | 2012-06-11 | 콩 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물 |
Country Status (4)
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US (1) | US9572765B2 (ko) |
KR (1) | KR20120136581A (ko) |
CN (2) | CN107050097A (ko) |
WO (1) | WO2012169860A2 (ko) |
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US10080714B2 (en) * | 2015-11-19 | 2018-09-25 | Avon Products, Inc. | Peptides and their use in the treatment of hair |
KR102457074B1 (ko) | 2015-12-31 | 2022-10-19 | 엘지디스플레이 주식회사 | 표시 장치 |
KR102249710B1 (ko) * | 2017-10-20 | 2021-05-10 | (주)아모레퍼시픽 | 콩 배양조직 추출물을 포함하는 탈모방지 또는 육모촉진용 조성물 및 이의 제조방법 |
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- 2012-06-11 CN CN201710002324.2A patent/CN107050097A/zh active Pending
- 2012-06-11 CN CN201280038928.8A patent/CN103702660A/zh active Pending
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CN107050097A (zh) | 2017-08-18 |
US20140093470A1 (en) | 2014-04-03 |
US9572765B2 (en) | 2017-02-21 |
KR20120136581A (ko) | 2012-12-20 |
WO2012169860A3 (ko) | 2013-03-07 |
CN103702660A (zh) | 2014-04-02 |
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