WO2012126198A1

WO2012126198A1 - Acid-base neutralizing solution for chemical burning protection

Info

Publication number: WO2012126198A1
Application number: PCT/CN2011/074303
Authority: WO
Inventors: 李亮; 吴稚伟; 孙亦彬; 蒋海燕
Original assignee: 南京维赛医药科技有限公司
Priority date: 2011-03-18
Filing date: 2011-05-19
Publication date: 2012-09-27
Also published as: CN102764268A; CN102133226A

Abstract

One type of human body decontamination solution used for industrial safety protection, especially one type of acid-base neutralizing solution used for chemical burning protection, includes complex agent, saccharide, polyethylene glycol, monovalent metal salt, polyvalent metal salt, polyalcohol, pH regulator and water. The protection purpose can be achieved by neutralizing the strong acid or base using polyvalent metal salt in the decontamination solution, and the burning position also can be repaired by extracting chemical substance from human body tissues. The decontamination solution presents the advantages of stability, long period of validity and facility for deposition and regulation. The decontamination solution is applicable to the emergency protection rescue of industrial safety protection in the chemical burning accident, especially strong acid-base burning accident, on human body.

Description

Acid-base neutralizing liquid for protecting chemical substances from burning

The invention relates to a human body decontaminating liquid used in the field of industrial safety protection, in particular to an acid-base neutralizing liquid for protecting a human body from being burned by a chemical substance. Background technique

In modern industrial production, especially in the case of using various strong acid and alkaline substances, there are often accidents in which strong acid and alkaline substances are accidentally leaked to cause burns to human bodies. In order to avoid or reduce the erosion of strong acid and alkaline substances on human body burns, neutral or weak alkaline solutions such as water, physiological saline or soapy water are generally used for decontamination and emergency protection treatment, which have certain effects. However, in an emergency situation, it is difficult to identify the types of erosive materials in a timely manner, and the traditional type of decontamination liquid is single, and it is impossible to treat the disease and rescue it. For example, water can only clean the surface, but can not capture the chemical substances entering the inner layer of the human skin, so that the decontamination effect is greatly limited, which delays the optimal rescue opportunity to some extent, and even causes the sequela of human body burns. Another example is the chemical burn medicine recorded in the "Inorganic Chemistry Experiment Lecture" prepared by the School of Chemistry and Materials Science of Central South University for Nationalities in December 2006: 5% sodium bicarbonate, 1% boric acid, 2% acetic acid, ammonia water, 2% Copper sulfate solution. Although it is theoretically feasible, the decontamination effect in practical applications is not obvious, and the repair of the burned parts of the human body is basically free of pharmacological effects.

Another class of drugs, such as Chinese Patent Application No. 03156924.2, discloses "a multifunctional combination of agents for treating burns, chemical burns and skin diseases", the combination of which contains kanamycin or amikacin, Plu There are three main components of cain and cod liver oil, and penicillin, dexamethasone, gentamicin or a combination thereof may be added separately. It is said that the agent is in contact with the wound skin without special treatment, and is directly applied to the wound surface, and the curative effect is extremely remarkable. Further, as disclosed in Chinese Patent Application No. 200610086919.2, "a pharmaceutical composition for treating burns and burns and a preparation method thereof", the main components of the pharmaceutical composition described are: rhubarb, cork, white, yellow, berberine, comfrey You can also add a small amount of borneol and musk. It is said to be used for the treatment of burns, electric burns, oil burns, acid-base burns and skin traumas. It has good curative effect, quick effect and high cure rate. However, these drugs are all therapeutic drugs after burns in human body, and are not suitable for emergency rescue treatment at the site of industrial safety and protection accidents.

According to reports, the Diphoterine product of Prevor, France, is an acid-base amphoteric chelating agent. It has not yet disclosed the composition of its chemical solution. It can be applied to chemical substances on the human body. Multi-purpose decontamination of infringement. It is said that its chemical molecular structure has a strong absorption property after being changed, and it can immediately combine with the chemicals invading the human body, and it is discharged from the human body. It is unmatched by water washing, and has high efficiency and rapidity. Features. However, the product still has the following shortcomings: First, the cost is high, the price is expensive, and its application range is greatly limited; secondly, the repairing effect on the affected part of the human body is not complete; the third is that the drug has a short effective period, which is not only expensive to use. And is not conducive to long-term storage management.

In summary, how to overcome the shortcomings of the prior art has become a major problem to be solved in the field of industrial security protection. Summary of the invention

The object of the present invention is to provide an acid-base neutralizing liquid for protecting a human body from being burned by a chemical substance in order to overcome the deficiencies of the prior art. When the human body is attacked by chemical substances, particularly strong acid and alkaline substances, the present invention can be It acts on the burned parts of human body to reduce the burning of chemical substances on the human body.

An acid-base neutralizing solution for protecting a human body from being burned by a chemical substance according to the present invention, which comprises a complexing agent, a sugar, a polyethylene glycol, a monovalent metal salt, a polyvalent metal salt, a polyhydric alcohol, PH conditioner and water. 2 - 10%, a valence metal salt 0. 2 - 10%, a polyvalent ethylene glycol 0. 2 - 2%, a monovalent metal salt 0. 1 - 10% 0重量。 The polyvalent metal salt 0. 5-20%, polyol 0. 1 _ 3.5%, PH regulator 0.1-1%, the rest is water, added to 100%. The bismuth metal is a polyvalent ethylene glycol 0.5-1.2%, a polyethylene compound, a poly-ethylene glycol 0.5-1.2%, a monovalent metal, a weight ratio of the compound: 2. 33-7%, sugar 0. 5-2.5%, polyethylene glycol 0. 5 - 1.2%, monovalent metal Salts 0. 8-8%, polyvalent metal salt 0. 9- 16 polyol 0. 3- 3.5%, pH regulator 0. 25-6%, the rest is water, added to 100%. The complexing agent in the proportioning component of the present invention is one or more of ethylenediaminetetraacetic acid disodium salt, gluconic acid or boric acid, and plays a role in ensuring the polyvalent metal salt in the neutralizing liquid of the present invention. And a rapid reaction occurs; the sugar in the proportioning component of the present invention is a mixture of one or both of glucose or sucrose, which functions as a water absorbing and moisturizing effect in the neutralizing liquid of the present invention; The polyethylene glycol in the portion functions to adjust the viscosity in the present invention; the monovalent metal salt in the proportioning component of the present invention is a water-soluble salt of potassium or sodium, which is used in the neutralizing liquid of the present invention. To adjust the osmotic pressure of the product, the appropriate osmotic pressure can promote the exudation of human body fluid, thereby avoiding the penetration of acid or alkali into the human dermal tissue; the polyvalent metal salt in the proportioning component of the present invention is calcium, aluminum or One or more of the water-soluble salts of iron play a role in reacting with an acid or a base to rapidly reduce acidity or alkalinity in the neutralizing liquid of the present invention; the polyol in the proportioning component of the present invention is pentaerythritol. One or more of mannitol or glycerin, The neutralizing liquid of the invention plays a water retaining role to prevent the skin from being damaged by water loss; the pH adjusting agent in the proportioning component of the invention is citric acid, and the citric acid can adjust the pH value of the finished liquid of the invention to reach 6-8. The composition of the above-mentioned proportioning component is dissolved in water and thoroughly mixed to obtain a finished neutralizing liquid of the present invention.

The invention has significant advantages compared with the prior art: First, the invention achieves the purpose of neutralization by reacting a polyvalent metal salt with a strong acid and a basic substance to achieve the purpose of protection, and the invention acts on the human body. The osmotic pressure is much higher than the normal plasma osmotic pressure of the human body. The chemical substances that erode the human body, especially the strong acid and alkaline substances, are extracted from the human tissue, which obviously reduces the penetration and erosion of chemical substances, especially strong acid and alkaline substances into human tissues. It has a significant repair effect on the burned parts of the human body. Secondly, the invention has low cost, high quality and low price, and is particularly suitable for large-scale emergency protection during large and medium-sized accidents. Third, the performance of the finished product of the present invention is stable, the drug has a long effective period, is convenient for reserve management, and the use cost is greatly reduced. The invention is suitable for emergency protection and protection of human body burn accidents by chemical substances, especially strong acid and alkaline substances in the field of industrial safety protection. detailed description

The invention will be further described in detail below with reference to the embodiments.

The invention provides an acid-base neutralizing liquid for protecting a human body from being burned by a chemical substance, which comprises a complexing agent, a sugar, a polyethylene glycol, a monovalent metal salt, a polyvalent metal salt, a polyhydric alcohol, a PH regulator and water. 1-10%, Polyvalent ethylene glycol 0. 1-1%, monovalent metal salt 0. 1 - 10%, the composition of the composition of the present invention is: 5-7%, sugar 0. 2- 3%, polyethylene glycol 0. 1-1%, monovalent metal salt 0. 1 - 10% , the polyvalent metal salt is 0.5 to 20%, the polyol is 0.1 to 3.5%, the pH regulator is 0.1 to 10%, and the balance is water, and is added to 100%. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 8%, polyvalent metal salt 0. 9_ 16%, polyol 0. 3 -3.5% PH regulator 0. 25 _6%, the rest is water, added to 100%.

All raw materials used in the present invention are commercially available chemical raw materials, which comply with the Pharmacopoeia standards of the People's Republic of China. In the following examples, the neutralization ability of the neutralizing liquid of the present invention is represented by acid neutralization force and alkali neutralization force. That is, the alkali neutralization force is: neutralize the volume of 1 ml of the neutralized solution of 1 mol of 1 liter of sodium hydroxide to a pH equal to 10; the acid neutralization force is: neutralize 1 ml of the concentration of 1 mol of I liter The amount of hydrochloric acid to the volume of the neutralizing solution used for pH equal to 5. The invention has the advantages of alkali neutralization force 10-35, acid neutralization force 10-35, osmotic pressure greater than 800 kPa and pH value 6-8 of the finished neutralizing liquid product. Example 1: The components by weight ratio of the present invention are: 3% of aluminum trichloride, 1% of boric acid, 3% of disodium edetate, sodium chloride 1.5%, polyethylene glycol 1 2%, glucose 1.5%, glycerol 2.5%, citric acid 0.5%, water 85.8%; The components are dissolved in water, and mixed thoroughly to obtain a finished neutralized liquid. The alkali neutralization force of the finished product was 35, the acid neutralization force was 30, the osmotic pressure was 1200 kPa, and the pH was 7.5.

Example 2: The components according to the weight ratio of the invention are: 8% aluminum chloride, 8% calcium chloride, 0.5% boric acid, 5% ethylenediaminetetraacetic acid disodium salt, sodium chloride 7%. PEG, 0.5%, sucrose 0.5%, pentaerythritol 0.3%, 5% citric acid, water 65.2%; The components are dissolved in water, mixed thoroughly to obtain the finished liquid. The alkali neutralization force of the finished product was measured 21, the acid neutralization force 26, the osmotic pressure 2400 kPa, and the pH value 6.5.

The 5% by weight of the composition of the present invention: 3% of aluminum sulfate, 0.8% of gluconic acid, 4% of boric acid, 1% of potassium chloride, 0.5% of polyethylene glycol, 1% of glucose, 1% of glucose, Sucrose 0. 5%, glycerol 0.5%, citric acid 1%, water 87.7%; The components are dissolved in water, and mixed thoroughly to obtain a finished neutralized liquid. The alkali neutralization force of the finished product was measured 37, the acid neutralization force 31, the osmotic pressure was 1600 kPa, and the pH was 7.3.

Example 4: The components according to the weight ratio of the invention are: ethylenediaminetetraacetic acid disodium salt 2%, aluminum trichloride 0.9%, glucose 2.5%, boric acid 0.33%, potassium chloride 0.8%, polyethylene glycol 0.8% of alcohol, 1% of mannitol, 0.25% of citric acid, 1.7% of glycerin, and 89.72% of water; the components were dissolved in water and thoroughly mixed to obtain a finished liquid of the neutralized liquid. The alkali neutralization force of the finished product was measured, 27, acid neutralization force 30, osmotic pressure 1200 kPa, and pH 6.5.

Example 5: The components according to the weight ratio of the present invention are: 5% gluconic acid, 10% calcium chloride, 1% glucose, 2% boric acid, 0.8% potassium chloride, 0.5% polyethylene glycol, mannitol 1 %, 6% citric acid, 2% glycerin, 87.9% water; the components are dissolved in water and mixed thoroughly to obtain a finished neutralized liquid. The alkali neutralization force of the finished product was measured, 25, acid neutralization force 22, osmotic pressure 1500 kPa, and pH 6.5.

Example 6: The components by weight ratio of the present invention are: 5% ethylenediaminetetraacetic acid disodium salt, 5% ferric chloride, glucose 1.5%, potassium chloride 8%, polyethylene glycol 1 %, mannitol 1%, citric acid 3%, glycerol 2.5%, water 83%; The components are dissolved in water and thoroughly mixed to obtain a finished neutralized liquid. The alkali neutralization force of the finished product was measured, 28, acid neutralization force 25, osmotic pressure 2200 kPa, and pH 7.8.

Example 7: The weight ratio components of the present invention are: ethylenediaminetetraacetic acid disodium salt 0.5%, glucose, sucrose 2.0%, polyethylene glycol 2.0%, potassium chloride 0.5%, aluminum trichloride 0.4. %, glycerin 2.0%; citric acid 0.1%, water 91.5%; the components are dissolved in water, and mixed thoroughly to obtain a finished neutralized liquid. The alkali neutralization force 33, acid neutralization force 31, osmotic pressure 1250 kPa, and pH value 6.2 of the finished product were measured. Example 8: The components by weight ratio of the present invention are: gluconic acid 0.5%, boric acid 0.3%, glucose 0.4%, polyethylene glycol 1.6%, sodium chloride 5.0%, calcium chloride 2.0%, mannitol 1.5. %, citric acid 7.5%, water 81.2%; The components are dissolved in water and mixed thoroughly to obtain a finished neutralized liquid. The alkali neutralization force 29 of the finished product, acid neutralization force 30, osmotic pressure 1700 kPa, and pH value 6 were measured.

Example 9: The weight ratio components of the present invention are: 0.8% of ethylenediaminetetraacetic acid disodium salt, 0.4% of gluconic acid, 0.3% of glucose, 0.3% of polyethylene glycol, 10.0% of potassium chloride, and chlorination. Calcium 7.0%, pentaerythritol 0.2%, citric acid 5.0%, water 76%; The components are dissolved in water and thoroughly mixed to obtain a neutralized liquid product. The alkali neutralization force of the finished product was measured 23, acid neutralization force 29, osmotic pressure 1800 kPa, ? 11 value 7.5.

Example 10: The components by weight ratio of the present invention are: 1.2% of ethylenediaminetetraacetic acid disodium salt, 0.7% of boric acid, 0.2% of glucose, 0.2% of polyethylene glycol, 0.1% of sodium chloride, and trichlorination. Iron 20.0%, mannitol 0.1%, citric acid 0.5%, water 77%; The components are dissolved in water and thoroughly mixed to obtain a finished neutralized liquid. The alkali neutralization force of the finished product was measured 32, acid neutralization force 28, osmotic pressure 1100 kPa, ? 11 value of 6.6.

Claims

Claim

1. An acid-base neutralizing liquid for protecting a human body from being burned by a chemical substance, which is characterized by comprising a complexing agent, a sugar, a polyethylene glycol, a monovalent metal salt, a polyvalent metal salt, a polyhydric alcohol, and a ra regulator. And water.

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 %, monovalent metal salt 0. 1_ 10%, polyvalent metal salt 0. 5- 20% polyol 0. 1_3.5%, PH adjusted Qi IJ O. 1_ 10%, the rest is water, added to 100%.

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ %, monovalent metal salt 0. 8_8%, polyvalent metal salt 0. 9_ 16%, polyol 0. 3_3.5%, PH adjustment Qi IJ O. 25 _ 6%, the rest is water, supplemented to 100%.

The acid-base neutralizing solution according to claim 1, 2 or 3, wherein the complexing agent is one or more of ethylenediaminetetraacetic acid disodium salt, gluconic acid or boric acid.

The acid-base neutralizing solution according to claim 1, 2 or 3, wherein the sugar is one or both of glucose or sucrose.

The acid-base neutralizing solution according to claim 1, 2 or 3, wherein the monovalent metal salt is a water-soluble salt of potassium or sodium.

The acid-base neutralizing solution according to claim 1, 2 or 3, characterized in that the polyvalent metal salt is one or more of a water-soluble salt of calcium, aluminum or iron.

The acid-base neutralizing solution according to Claim 1, 2 or 3, characterized in that the polyol is one or more of pentaerythritol, mannitol or glycerin.

The acid-base neutralizing solution according to claim 1, 2 or 3, characterized in that the pH adjusting agent is citric acid.