CN102764268A - Acid-base neutralization solution for protecting human body from being burned by chemical substances - Google Patents
Acid-base neutralization solution for protecting human body from being burned by chemical substances Download PDFInfo
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- CN102764268A CN102764268A CN2012100694297A CN201210069429A CN102764268A CN 102764268 A CN102764268 A CN 102764268A CN 2012100694297 A CN2012100694297 A CN 2012100694297A CN 201210069429 A CN201210069429 A CN 201210069429A CN 102764268 A CN102764268 A CN 102764268A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
The invention relates to a human body decontamination solution used in the field of industrial safety protection, especially to an acid-base neutralization solution for protecting human body from being burned by chemical substances. The acid-base neutralization solution comprises a complexing agent, sugar, polyethylene glycol, monovalent metal salt, polyvalent metal salt, polyol, a pH conditioning agent and water. The purpose of protection can be realized through a reaction between polyvalent metal salt and a strong acid/alkali substance. When human body is burned and eroded by chemical substances especially strong acid/alkali substances, the acid-base neutralization solution has a very good effect of repairing burned and eroded positions of human body, has stable properties, is convenient to store and manage, and is especially suitable for long-range emergency protective rescue after occurrence of large and medium-sized accidents so as to mitigate burning and erosion of human body by chemical substances.
Description
One, technical field
The present invention relates to a kind of human body decontamination solution that is used for industrial safety protection field, particularly a kind ofly be used to protect the acid-base neutralization liquid that human body is burnt by chemical substance.
Two, background technology
In the modern industrial, particularly use the occasion of various strong acid alkaline matters, strong acid alkaline matter accidental release is often arranged and produce accident that human body is burnt and take place.For avoiding or erosion when alleviating the strong acid alkaline matter human body being burnt as far as possible, generally adopt neutrality such as water, normal saline or suds or weakly alkaline solution carries out decontamination and emergence control is handled, have certain function.But under emergency owing to be difficult to the kind in time distinguish corrosive substance, and traditional decontamination solution kind single, can't suit the remedy to the case, realize suing and labouring due to wound.Can only clean surface like water, and can not catch the chemical substance that gets into the human body skin internal layer, make decontaminating effect restricted greatly, incured loss through delay the best opportunity of suing and labouring in a way, even the sequela that can cause human body to burn.Chemical burn medicine of record in South-Center University For Nationalities chemistry and material science institute in the December, 2006 " the Experiment of Inorganic Chemstry teaching materials " of writing and for example: the copper-bath that contains 5% sodium bicarbonate, 1% boric acid, 2% acetic acid, ammonia and 2%.Though it is feasible in theory, the decontaminating effect in the practical application is also not obvious, and the burn reparation at position has basically no the pharmacological curative effect to human body.For overcoming the deficiency of existing industrial safety preventive means; One Chinese patent application 200610086919.2 discloses " a kind of pharmaceutical composition of treating empyrosis and preparation method thereof "; The main component of the pharmaceutical composition of its record is: Radix Et Rhizoma Rhei, phellodendron bark, Cortex ulmi pumilae, Radix Scutellariae, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) can also add a small amount of Borneolum Syntheticum and Moschus.Can be used for treating burn, electric injury, oil scald, soda acid burn and traumatic injury of skin etc., good effect, instant effect and cure rate are high.But it only belongs to the medicine after the wound, is not suitable for industrial safety protection the emergent of the scene of the accident and sues and labours.In sum, the deficiency that how to overcome prior art has become one of great difficult problem that current industrial safety protection field needs to be resolved hurrily.
Three, summary of the invention
The objective of the invention is provides a kind of acid-base neutralization liquid that human body is burnt by chemical substance that is used to protect for the deficiency that overcomes prior art; When human body receive chemical substance particularly the strong acid alkaline matter burn when corroding; The present invention can act on the human body attack sites of burning, to alleviate the burn erosion of chemical substance to human body.
A kind of being used to that proposes according to the present invention protected the acid-base neutralization liquid that human body is burnt by chemical substance, it is characterized in that comprising chelating agent, sugar, Polyethylene Glycol, univalent metal salt, multivalent metal salt, polyhydric alcohol, PH regulator and water.The present invention's component by weight ratio is: chelating agent 0.5-7%, sugared 0.2-3%, Polyethylene Glycol 0.2-2%, univalent metal salt 0.1-10%, multivalent metal salt 0.5-20%, polyhydric alcohol 0.1-3.5%, PH regulator 0.1-10%, all the other are water, are supplemented to 100%.The further preferred version of the present invention; Component by weight ratio is: chelating agent 2.33-7%, sugared 0.5-2.5%, Polyethylene Glycol 0.5-1.2%, univalent metal salt 0.8-8%, multivalent metal salt 0.9-16%, polyhydric alcohol 0.3-3.5%, PH regulator 0.25-6%, all the other are water, are supplemented to 100%.Chelating agent in the proportioning component of the present invention is one or more in disodium EDTA, gluconic acid or the boric acid, in neutralizer of the present invention, play guarantee multivalent metal salt in the time rapid-action effect takes place; Sugar in the proportioning component of the present invention is one or both the mixture in glucose or the sucrose, in neutralizer of the present invention, plays the suction moisture-keeping function; Polyethylene Glycol in the proportioning component of the present invention plays the effect of regulating viscosity in of the present invention; Univalent metal salt in the proportioning component of the present invention is the water soluble salt of potassium or sodium; In neutralizer of the present invention, play the effect of the osmotic pressure of regulating product; Suitable osmotic pressure can promote oozing out of human body fluid, thereby avoids the infiltration to the human body dermal tissue of acid or alkali; Multivalent metal salt in the proportioning component of the present invention is one or more in the water soluble salt of calcium, aluminum or ferrum, in neutralizer of the present invention, plays with acid or alkali reaction and reduces acid or alkaline effect rapidly; Polyhydric alcohol in the proportioning component of the present invention is one or more in tetramethylolmethane, mannitol or the glycerol, in neutralizer of the present invention, plays water retention, prevents that skin from coming to harm because of dehydration; PH regulator in the proportioning component of the present invention is a citric acid, and the pH value that citric acid can be regulated neutralizer finished product of the present invention reaches 6-8.Constituent in the said ratio component is used water dissolution, can make neutralizer finished product of the present invention through abundant mixing.
The present invention compared with prior art its remarkable advantage is: first; The present invention can realize that through multivalent metal salt and strong acid alkali substance reaction neutral principle reaches the protection purpose; The present invention acts on the osmotic pressure of human body greater than 800 kPa; Normal plasma osmotic pressure (about 770kPa) height than human body self; This high osmosis can alleviate the strong acid alkaline matter and corrode to the infiltration of tissue the chemical substance that corrodes human body from organizing interior extraction, and the human body attack sites of being burnt is had repairing effect preferably.The second, the not only emergent protection of the present invention is sued and laboured effective, and preparation cost is low, is specially adapted to the emergent on a large scale protection after the big-and-middle-sized accident generation is sued and laboured.The 3rd, backlog control is convenient in stable performance of the present invention.The present invention be applicable to chemical substance in the industrial safety protection field to human body the burn emergent protection of accident sue and labour.
Existing compare with the normal saline in acid-base neutralization liquid of the present invention and the above-mentioned background technology and chemical burn medicine (copper-bath that contains 5% sodium bicarbonate, 1% boric acid, 2% acetic acid, ammonia and 2%); Further specify the correlated remarkable actual effect of the present invention and prior art, the experimental data of each decontaminant is shown in table 1, table 2, table 3, table 4, table 5 and table 6.
PH value is with decontaminant change in volume curve during the HCL of the different decontaminants of table 1 flushing 1ml 1mol/L
PH value is with decontaminant change in volume curve during the NaOH of the different decontaminants of table 2 flushing 1ml 1mol/L
PH value was with decontaminant change in volume curve when table 1 was the HCL of different decontaminants flushing 1ml 1mol/L, the data show in the table 1, and 30 ml acid-base neutralization liquid can make the pH value of the hydrochloric acid solution (pH1.30) of 1ml (1 mol/L) be increased to 5.92.PH value change curve when table 2 is NaOH of different decontaminants flushing 1ml 1mol/L, the data show in the table 2,30 ml acid-base neutralization liquid can make the pH of the NaOH solution (pH 13.00) of 1ml (1 mol/L) be reduced to 8.95.Data declaration in table 1 and the table 2 acid-base neutralization liquid of the present invention acid solution or aqueous slkali are all had neutralization preferably; Can reach the pH value scope 5.5 ~ 9.0 of human body not being had chemical burn; And acid-base neutralization liquid consumption that can be less solves human body and burnt and corrode the difficult problem of emergency processing, helps improving the actual effect of later stage healing.Data in table 1 and the table 2 explain that also normal saline does not have neutralization to acid solution, have only diluting effect, use the normal saline dilution may cause the burnt further expansion of attack sites area of human body, increase the infringement to human body.
System temperature change curve when the different decontaminants of table 3 wash 95% sulphuric acid
Table 3 is different decontaminants system temperature change curves when washing 95% sulphuric acid.Data show in the table 3, chemical burn medicine when flushing initial temperature reaches 117 ℃, and initial temperature has reached 102 ℃ during normal saline flushing, and initial temperature is 86 ℃ when using acid-base neutralization liquid flushing of the present invention; Along with continuous flushing; It is fastest that acid-base neutralization liquid system temperature reduces, and when consuming 15 ml, system temperature has just dropped to 35 ℃; Be lower than 43 ℃ of the thermal valve values of skin injury, and the chemical burn medicine and the normal saline system temperature of same consumption still maintain the high temperature more than 70 ℃.Can discharge great amount of heat in order to solve when concentrated sulphuric acid is met the water dilution, temperature rising meeting causes a chemistry and the dual difficult problem of burning of heat to human body skin, and using acid-base neutralization liquid of the present invention decontamination is best selection.
| The decontaminant title | The skin wound maximum temperature (℃) |
| The chemical burn medicine | 63.7 |
| Normal saline | 56.4 |
| Acid-base neutralization liquid | 39.2 |
During the different decontaminant decontamination of table 4 by the maximum temperature of concentrated sulphuric acid burn wound surface relatively
Table 4 is different decontaminant decontaminations maximum temperature comparisons to Cavia porcellus concentrated sulphuric acid burn wound surface.Data show in the table 4; The skin wound maximum temperature rises to 63.7 ℃ during the decontamination of chemical burn medicine; The skin wound maximum temperature also rises to 56.4 ℃ during the normal saline decontamination, and both temperature all above 43 ℃ of the thermal valve values of skin injury, are prone to cause thermodynamics to burn to skin.And maximum temperature is merely 39.2 ℃ during with acid-base neutralization liquid decontamination of the present invention, is lower than 43 ℃ of the thermal valve values of skin injury.Can discharge great amount of heat in order to solve when concentrated sulphuric acid is met the water dilution, temperature rising meeting causes a chemistry and the dual difficult problem of burning of heat to human body skin, uses acid-base neutralization liquid of the present invention the protective effect of skin obviously is superior to chemical burn medicine and normal saline.
Different time GPS IL-6 content after the different decontaminant decontaminations of table 5
Different time GPS TNF content after the different decontaminant decontaminations of table 6
Table 5 is a different time GPS IL-6 content after the different decontaminant decontaminations; Table 6 is a different time GPS TNF content after the different decontaminant decontaminations.GPS IL-6 and TNF content when the data show of table 5 and table 6, untreated matched group, normal saline, chemical burn medicine or acid-base neutralization liquid are applied to decontamination guinea pig skin hydrochloric acid burn wound surface.Adopt normal saline, chemical burn medicine can both reduce the level of blood serum IL-6 (interleukin-6) and TNF (tumor necrosis factor); But acid-base neutralization liquid is more remarkable to the level that reduces IL-6 and TNF, and this explanation acid-base neutralization liquid decontamination will have the better protection effect to the skin of salt acid burn.
Four, description of drawings
The photo sketch map of Fig. 1 guinea pig skin concentrated sulphuric acid burn wound surface after with the decontamination of chemical burn medicine
The photo sketch map of Fig. 2 guinea pig skin concentrated sulphuric acid burn wound surface after with the decontamination of acid-base neutralization liquid.
The photo sketch map of the saturated sodium hydroxide burn wound surface of Fig. 3 guinea pig skin after with the decontamination of chemical burn medicine.
The photo sketch map of the saturated sodium hydroxide burn wound surface of Fig. 4 guinea pig skin after with the decontamination of acid-base neutralization liquid.
The photo sketch map of Fig. 5 guinea pig skin saturated salt acid burn wound surface after with the decontamination of chemical burn medicine.
The photo sketch map of Fig. 6 guinea pig skin saturated salt acid burn wound surface after with the decontamination of acid-base neutralization liquid.
PH value is with decontaminant change in volume curve during the HCL of the different decontaminants of Fig. 7 table 1 flushing 1ml 1mol/L.
PH value is with decontaminant change in volume curve during the NaOH of the different decontaminants of Fig. 8 table 2 flushing 1ml 1mol/L.
System temperature change curve when the different decontaminants of Fig. 9 table 3 wash 95% sulphuric acid.
During the different decontaminant decontamination of Figure 10 table 4 by the maximum temperature of concentrated sulphuric acid burn wound surface relatively.
Different time GPS IL-6 content after the different decontaminant decontaminations of Figure 11 table 5.
Different time GPS TNF content after the different decontaminant decontaminations of Figure 12 table 6.
Five, the specific embodiment
Do further to specify below in conjunction with embodiment and accompanying drawing specific embodiments of the invention.
Five, the specific embodiment
Do further to specify below in conjunction with embodiment and accompanying drawing specific embodiments of the invention.
A kind of being used to that the present invention proposes protected the acid-base neutralization liquid that human body is burnt by chemical substance, comprises chelating agent, sugar, Polyethylene Glycol, univalent metal salt, multivalent metal salt, polyhydric alcohol, PH regulator and water; Component by weight ratio is: chelating agent 0.5-7%, sugared 0.2-3%, Polyethylene Glycol 0.2-2%, univalent metal salt 0.1-10%, multivalent metal salt 0.5-20%, polyhydric alcohol 0.1-3.5%, PH regulator 0.1-10%, all the other are water, are supplemented to 100%;
The preferred version of component by weight ratio is: chelating agent 2.33-7%, sugared 0.5-2.5%, Polyethylene Glycol 0.5-1.2%, univalent metal salt 0.8-8%, multivalent metal salt 0.9-16%, polyhydric alcohol 0.3-3.5%, PH regulator 0.25-6%, all the other are water, are supplemented to 100%.All raw materials that the present invention adopts are commercially available medical material, meet the Pharmacopoeia of People's Republic of China standard.In following examples, represent the neutralising capacity of neutralizer of the present invention with sour counteragent and alkali counteragent.Be that the alkali counteragent is: in 1 ml concn be the sodium hydroxide of 1 mol equals 10 used neutralizers to PH volume number; The acid counteragent is: in 1 ml concn be the hydrochloric acid of 1 mol equals 5 used neutralizers to PH volume number.The present invention is certified products to make the alkali counteragent 10-35 of neutralizer finished product, sour counteragent 10-35, osmotic pressure greater than 800 kPa and pH value 6-8.
Embodiment 1:The present invention's component by weight ratio is: aluminum chloride 3%, boric acid 1%, disodium EDTA 3%, sodium chloride 1.5%, Polyethylene Glycol 1.2%, glucose 1.5%, glycerol 2.5%, citric acid 0.5%, water 85.8%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.Record alkali counteragent 35, sour counteragent 30, osmotic pressure 1200 kPa, the pH value 7.5 of its finished product.
Embodiment 2:The present invention's component by weight ratio is: aluminum chloride 8%, calcium chloride 8%, boric acid 0.5%, disodium EDTA 5%, sodium chloride 7%, Polyethylene Glycol 0.5%, sucrose 0.5%, tetramethylolmethane 0.3%, citric acid 5%, water 65.2%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.Record alkali counteragent 21, sour counteragent 26, osmotic pressure 2400 kPa, the pH value 6.5 of its finished product.
Embodiment 3: the present invention's component by weight ratio is: aluminum sulfate 3%, gluconic acid 0.8%, boric acid 4%, potassium chloride 1%, Polyethylene Glycol 0.5%, glucose 1%, sucrose 0.5%, glycerol 0.5%, citric acid 1%, water 87.7%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.Record alkali counteragent 37, sour counteragent 31, osmotic pressure 1600 kPa, the pH value 7.3 of its finished product.
Embodiment 4:The present invention's component by weight ratio is: disodium EDTA 2%, aluminum chloride 0.9%, glucose 2.5%, boric acid 0.33%, potassium chloride 0.8%, Polyethylene Glycol 0.8%, mannitol 1%, citric acid 0.25%, glycerol 1.7%, water 89.72%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.。Record alkali counteragent 27, sour counteragent 30, osmotic pressure 1200 kPa, the pH value 6.5 of its finished product.
Embodiment 5:The present invention's component by weight ratio is: gluconic acid 5%, calcium chloride 10%, glucose 1%, boric acid 2%, potassium chloride 0.8%, Polyethylene Glycol 0.5%, mannitol 1%, citric acid 6%, glycerol 2%, water 87.9%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.Record alkali counteragent 25, sour counteragent 22, osmotic pressure 1500 kPa, the pH value 6.5 of its finished product.
Embodiment 6:The present invention's component by weight ratio is: ethylenediaminetetraacetic acid 5%, ferric chloride 5%, glucose 1.5%, potassium chloride 8%, Polyethylene Glycol 1%, mannitol 1%, citric acid 3%, glycerol 2.5%, water 83%; Each component is used water dissolution, promptly make the neutralizer finished product after fully mixing.Record alkali counteragent 28, sour counteragent 25, osmotic pressure 2200 kPa, the pH value 7.8 of its finished product.
Existing acid-base neutralization liquid and the chemical burn medicine in the above-mentioned background technology that makes with the present invention (contains 5% sodium bicarbonate, 1% boric acid; 2% acetic acid, ammonia and 2% copper-bath); Each 50ml; Be respectively applied for the decontamination guinea pig skin by the example that is treated to of chemical burn wound surface, the wound healing actual effect contrast after 24 hours sees the photo sketch map for details.
Fig. 1 is the photo sketch map of guinea pig skin concentrated sulphuric acid burn wound surface after with the decontamination of chemical burn medicine; Visible from Fig. 1; By the concentrated sulphuric acid skin ambustion with the decontamination of chemical burn medicine after; The burn vestige is still obvious because during the decontamination of chemical burn medicine because thermal burn has taken place in the too high skin that makes of temperature, cause wound tissue to suffer further damage.Fig. 2 is the photo sketch map of guinea pig skin concentrated sulphuric acid burn wound surface after with the decontamination of acid-base neutralization liquid, and is visible from Fig. 2, eliminates basically with wound surface carbonization vestige after the decontamination of acid-base neutralization liquid; Wound surface does not have the phenomenon of further damage; Because skin temperature is lower during the decontamination of acid-base neutralization liquid, except that the sulphuric acid of the skin surface that neutralized preferably, in addition because it has hypertonicity; The sulphuric acid that can penetrate to the skin and organize in the depths and get into deep skin keeps better the skin histology 26S Proteasome Structure and Function.Fig. 3 is the photo sketch map of the saturated sodium hydroxide burn wound surface of guinea pig skin after with the decontamination of chemical burn medicine; Fig. 4 is the photo sketch map of the saturated sodium hydroxide burn wound surface of guinea pig skin after with the decontamination of acid-base neutralization liquid; With in like manner aforementioned; With the saturated sodium hydroxide burn wound surface of acid-base neutralization liquid decontamination guinea pig skin, the actual effect of its healing obviously is superior to the chemical burn medicine.Fig. 5 is the photo sketch map of guinea pig skin saturated salt acid burn wound surface after with the decontamination of chemical burn medicine; Fig. 6 is the photo sketch map of guinea pig skin saturated salt acid burn wound surface after with the decontamination of acid-base neutralization liquid; With in like manner aforementioned; With acid-base neutralization liquid decontamination guinea pig skin hydrochloric acid burn wound surface, the actual effect of its healing obviously is superior to the chemical burn medicine.
The present invention has obtained satisfied effect through experimental verification repeatedly.
Claims (9)
1. one kind is used to protect the acid-base neutralization liquid that human body is burnt by chemical substance, it is characterized in that comprising chelating agent, sugar, Polyethylene Glycol, univalent metal salt, multivalent metal salt, polyhydric alcohol, PH regulator and water.
2. acid-base neutralization liquid according to claim 1; The composition by weight that it is characterized in that proportioning is: chelating agent 0.5-7%, sugared 0.2-3%, Polyethylene Glycol 0.2-2%, univalent metal salt 0.1-10%, multivalent metal salt 0.5-20%, polyhydric alcohol 0.1-3.5%, PH regulator 0.1-10%, all the other are water, are supplemented to 100%.
3. acid-base neutralization liquid according to claim 1; The composition by weight that it is characterized in that proportioning is: chelating agent 2.33-7%, sugared 0.5-2.5%, Polyethylene Glycol 0.5-1.2%, univalent metal salt 0.8-8%, multivalent metal salt 0.9-16%, polyhydric alcohol 0.3-3.5%, PH regulator 0.25-6%, all the other are water, are supplemented to 100%.
4. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that chelating agent is one or more in disodium EDTA, gluconic acid or the boric acid.
5. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that sugar is one or both in glucose or the sucrose.
6. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that univalent metal salt is the water soluble salt of potassium or sodium.
7. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that multivalent metal salt is one or more in the water soluble salt of calcium, aluminum or ferrum.
8. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that polyhydric alcohol is one or more in tetramethylolmethane, mannitol or the glycerol.
9. according to claim 1,2 or 3 described acid-base neutralization liquid, it is characterized in that the PH regulator is a citric acid.
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| CN2011100652482A CN102133226A (en) | 2011-03-18 | 2011-03-18 | Acid-base neutralizer for protecting human bodies from being burnt by chemical matters |
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| CN106214686A (en) * | 2016-07-01 | 2016-12-14 | 吉林大学珠海学院 | A kind of bionical tissue fluid with resist chemical |
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| US6527872B1 (en) * | 1999-07-28 | 2003-03-04 | Steris Inc. | Environmentally friendly peracetic acid decontamination formula with increased performance and chemical stability |
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| CN1919209A (en) * | 2006-07-10 | 2007-02-28 | 江西3L医用制品集团有限公司 | Pharmaceutical composition for healing skin wound |
| CN101698102A (en) * | 2009-05-13 | 2010-04-28 | 朱玛华 | Ultra-potent composite for decontaminating hazardous chemical substances |
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| Title |
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| 董静、施耘: "60例氢氟酸灼伤的早期处理", 《职业与健康》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214686A (en) * | 2016-07-01 | 2016-12-14 | 吉林大学珠海学院 | A kind of bionical tissue fluid with resist chemical |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102133226A (en) | 2011-07-27 |
| WO2012126198A1 (en) | 2012-09-27 |
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