CN101732341A - Washing-disinfecting liquid and disinfecting-washing bag thereof for radioactive skin contamination - Google Patents
Washing-disinfecting liquid and disinfecting-washing bag thereof for radioactive skin contamination Download PDFInfo
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- CN101732341A CN101732341A CN200910201523A CN200910201523A CN101732341A CN 101732341 A CN101732341 A CN 101732341A CN 200910201523 A CN200910201523 A CN 200910201523A CN 200910201523 A CN200910201523 A CN 200910201523A CN 101732341 A CN101732341 A CN 101732341A
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Abstract
The invention relates to the technical field of medical instruments, in particular to a washing-disinfecting liquid and a disinfecting-washing bag thereof for skin and wounds with radionuclide contamination. The invention discloses a washing-disinfecting liquid for radioactive skin contamination, which is characterized in that the washing-disinfecting liquid contains 0.5 to 10 percent of EDTA, 0.5 to 10 percent of citric acid, 0.5 to 10 percent of super sodium chloride, and 0.5 to 10 percent of aqueous solution of fatty alcohol sodium sulfate. The invention also discloses a washing-disinfecting bag for radioactive skin contamination, which is characterized in that the washing-disinfecting bag comprises the washing-disinfecting liquid. The washing-disinfecting liquid has the advantages of high decontamination rate and no stimulation to skin or wounds. The washing-disinfecting bag adopting disposable packaging has the characteristics of small volume, convenience for carrying and storage and convenient quick use. When the radionuclide contamination of the skin and the wounds is removed, the washing-disinfecting liquid and the disinfecting-washing bag need no washing, produce little secondary pollution, and ensure good decontamination effects, so the washing-disinfecting liquid and the disinfecting-washing bag can be allocated to personnel engaged in nuclear power, nuclear reactors, radiation devices and other radiation work in the army or local places in order to implement radioactive washing and disinfecting in nuclear accident emergency.
Description
Technical field
The present invention relates to technical field of medical instruments, be specifically related to a kind of lotion and decontamination bag thereof when being used for skin and wound radionuclide and being infected with.
Background technology
At present, existing more sophisticated military affairs of normal body surface decontamination of personnel and the decontamination of large tracts of land region and commercial technology, and, also be in the development exploratory experiment stage for the decontamination technology of small-sized sensor and personnel's radioactive pollution wound.For this reason, endeavour both at home and abroad to seek to sensitivity equipment and effective and suitable technology and the equipment thereof of personnel's wound decontamination.External skin detergent commonly used has porous belts, bar-shaped soap, waterfree hand cleaning agent, soft brush or LAVA soap, Russia has been equipped with IP P-3 disinfection box and has been used for individual soldier's decontamination, the M291 skin degerming bag of U.S.'s development is made of the sack of a purse-type, in adorn 6 pouches, a non-woven fibre mat that is full of disinfectant is arranged in each pouch, can carry out complete skin degerming 3 times, can be to the decontamination of meeting an urgent need of skin and contaminated wound.The RDS2000 decontamination solution of the U.S. is a kind of novel concentrated type decontamination solution, form by two kinds of compositions (polydextrose surfactant and citric acid-citrate buffer solution), be used for the decontamination on radioactive pollution surface, when using RDS2000, become aqueous solution earlier or become foam, be used further to surface decontamination, after one period response time, use high pressure water spray nozzle to wash the decontamination solution that contains radioactive substance.
China's decontamination technology development situation is compared also relatively low with developed countries, the decontaminant that is usually used in removing radioactive substance comprises detergent, chelating agent etc., is modulated into water according to a certain percentage usually and eliminates liquid and use.Detergent has dodecylbenzene sodium sulfonate and sodium alkyl sulfonate etc., in aqueous solution, can reduce the surface tension of water, and effects such as moistening, emulsifying, dispersion, foaming take place, and can strengthen the effect of the elimination radioactive contamination of water, be specially adapted to elimination to the grease surface.Detergent also comprises soda acid with dirt-removing power etc.Chelating agent has sodium hexameta phosphate, sodium ethylene diamine tetracetate (EDTA), tetrasodium pyrophosphate, sodium tripolyphosphate etc., can with many metal ion effects, generate can be water-soluble stable comple.Utilize this character of complex, the radioactive substance of body surface is transferred to eliminated in the liquid, reach and eliminate the purpose of being infected with.Chelating agent usually and detergent be used.During elimination, should be according to eliminating object, being infected with and selecting suitable remover in situation and season etc.Domestic skin radioactive-pollutant eliminating detergent goods commonly used (decontamination solution, decontamination soap etc.) are used for being infected with of healthy body surface mostly, and function is comparatively single, and pH value weak acid or weak base are not suitable for the radioactive-pollutant eliminating detergent of wound; And generally all need to use preceding situ configuration, can incur loss through delay some times, and widely apply flushing with clean water, decontaminating effect is general, and the secondary pollution of generation is many, is unfavorable for follow-up processing.Fast and effeciently remove radioactive contaminant, to reducing the radioactivity complex injury, it is very important winning and rescuing treatment time.At present domestic also not developing need not washing, the emergent decontamination product of radioactive contamination that physical absorption is merged with chemical decontamination principle.
Summary of the invention
Technical problem to be solved by this invention provides a kind of novel decontamination bag that is applicable to the radioactive contamination emergency processing, can directly in case of emergency remove the radioactive pollution of skin and wound.
Be the above-mentioned technical problem that solves, the invention discloses a kind of radioactive skin contamination decontamination solution, it comprises adsorptive pads and decontamination solution, it is characterized in that described decontamination solution is the aqueous solution that contains 0.5-10%EDTA, 0.5-10% citric acid, the super sodium chloride of 0.5-10% and 0.5-10% sodium alkyl sulfate.
The prescription of decontamination solution of the present invention is a mixture, mainly comprises EDTA, citric acid, sodium alkyl sulfate etc., pH value neutrality, action temperature and, right
131I,
60The soil removal efficiency height of Co.Decontamination solution of the present invention not only can be used for the radiation decontamination of skin, also can be used for the radiation decontamination of wound.
In certain embodiments, described decontamination solution can be preferably super sodium chloride of citric acid, 1-8% and the 1-8% sodium alkyl sulfate of 1-8%EDTA, 1-8%.
In certain embodiments, described decontamination solution can be preferably super sodium chloride of citric acid, 3-6% and the 3-6% sodium alkyl sulfate of 1.5-6%EDTA, 1.5-6%.
In certain embodiments, described decontamination solution can be preferably super sodium chloride of citric acid, 4-6% and the 5-6% sodium alkyl sulfate of 1.5-3%EDTA, 2-3%.
On the other hand, the invention also discloses a kind of radioactive skin contamination decontamination bag, it is characterized in that comprising described decontamination solution.But described radioactive skin contamination decontamination bag also comprises adsorptive pads, takes adsorptive pads to separate packing or adsorptive pads with decontamination solution and soaks and contain decontamination solution packing.
Adsorptive pads of the present invention can be weaving fiber pad or non-woven fibre mat or microporous sponge, wherein preferred microporous sponge.The microporous sponge water absorption is strong, contacts softly, has softness, and zest is little, and radionuclide is had good physisorption, the physical absorption of sponge and the chemical decontamination decontamination principle of mixing decontamination solution can be combined, and clean effect is strong.
Adsorptive pads of the present invention can be virtually any size or shape, wherein preferred 10-25cm * 10-25cm, and 15cm * 15cm most preferably is so that use and pack.
The present invention's decontamination solution soil removal efficiency of the present invention height, non-stimulated to skin and wound; Described decontamination bag is mainly used in the radioactive-pollutant eliminating detergent of skin, wound, can be by saving oneself, rescuing mutually, and the very first time is removed the radioactive pollution of wound, avoids degree of depth internal radiation, reduces wound infection and secondary pollution.Decontamination bag of the present invention is taked non-returnable container, have volume little, be easy to carry and preservation, characteristics convenient to use.When the radionuclide that the present invention removes skin and wound is infected with, need not washing, the secondary pollution of generation is few, and clean effect is good, configurable army and the local personnel that are engaged in radiation works such as nuclear power, nuclear reactor, radiological unit use, so that in emergency circumstances implement radiation decontamination in nuclear accident.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.These embodiment only are used to the present invention is described and are not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example is usually according to the normal condition or the condition of advising according to manufacturer.Unless otherwise defined, the same meaning that employed all specialties and scientific words and one skilled in the art are familiar with in the literary composition.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
Embodiment 1, decontaminating effect experiment
1, radionuclide choosing and obtaining
Buy CoCl
2, through the low dose rate fission neutron (
252Cf, absorbed dose rate are 0.35mGy/h) shine February, produce activation products
60Co,
131I is provided by Huangpu District central hospital.
2, the foundation of wound surface scratch model
The Fructus Foeniculi pig, 40mg/kg, the pentobarbital sodium lumbar injection, preserved skin is done skin well shape otch.
3, the screening of physical material
Choose microporous sponge, non-woven fabrics, hospital gauze (material), get the material of same area, same weight respectively, drip normal saline to oozing out, relatively water absorption with high absorption capacity, while contact surface gentleness; The Fructus Foeniculi pig, preserved skin, cutting 3cm * 3cm is divided into 4 groups of (blank group, sponge wiping group, non-woven fabrics wiping group, hospital gauze wiping group) experimental grouies and respectively is coated with 150 μ l's
60Co, 30 μ l
131I mixing radioactive nucleus cellulose solution, 3 kinds of physical material wipings respectively, measurement wiping front and back abrasion
60Co,
131I soil removal efficiency, relatively absorbability.The result as seen, gauze group and non-woven fabrics group are in high, medium and low dosage group, and be right
60Co,
131The clean effect of I is similar, and sponge group clean effect is apparently higher than gauze group and non-woven fabrics group, and is best with the high dose group clean effect.(referring to table 1,2)
C
0: the Co content (mg) on Corii Sus domestica surface before the decontamination
C
1: the Co content (mg) on Corii Sus domestica surface after the decontamination
Table 1: physical material is right
60The absorption soil removal efficiency (%) of Co
Table 2: physical material is right
131The absorption soil removal efficiency (%) of I
5, mix the preparation of decontamination solution group different component
The mixing decontamination solution (aqueous solution) of preparation different component is divided into 8 groups.
A:1%EDTA+1% citric acid+1% surpass sodium chloride+1% sodium alkyl sulfate;
B:8%EDTA, 8% citric acid, 8% surpass sodium chloride and 8% sodium alkyl sulfate;
C:1.5%EDTA, 3% citric acid, 6% surpass sodium chloride and 3% sodium alkyl sulfate;
D:6%EDTA, 4% citric acid, 4% surpass sodium chloride and 8% sodium alkyl sulfate;
E:3%EDTA, 7% citric acid, 6% surpass sodium chloride and 6% sodium alkyl sulfate;
F:2%EDTA, 4% citric acid, 3% surpass sodium chloride and 5% sodium alkyl sulfate;
G:3%EDTA, 2% citric acid, 3% surpass sodium chloride and 6% sodium alkyl sulfate;
H:1.5%EDTA, 2% citric acid, 3% surpass sodium chloride and 5% sodium alkyl sulfate.
6, decontaminating effect test
6.1 the preparation of different formulations decontamination solution
Prepare different decontamination solutions, be divided into 5 groups of matched groups, A, B, C, D, matched group: distilled water, A group: 5% soap water group, B group: 1.5%EDTA solution+4% sodium alkyl sulfate, the C group: 2% citric acid solution+4% sodium alkyl sulfate, the D group: mix decontamination solution group (prescription of f), each group is fully mixed the back and is soaked microporous sponge.
6.2 test decontaminating effect
The Fructus Foeniculi pig, preserved skin, cutting 3cm * 3cm wound is coated with 150 μ l's
60Co, 30 μ l
131I mixing radioactive nucleus cellulose solution, respectively group is used the microporous sponge wiping of soaking different decontamination solutions respectively, measurement wiping front and back abrasion
60Co,
131I soil removal efficiency, relatively dirt-removing power.The result shows: right
60Co,
131The decontamination of I, high, medium and low dosage group no matter, the clean effect of decontamination bag is apparently higher than matched group soap water group (p＜0.01); Wherein, especially with mixing formula group (D group) soil removal efficiency apparently higher than other the prescription decontamination solution group (p＜0.01) (referring to table 3,4)
Table 3: different formulations decontamination bag is right
60The absorption soil removal efficiency (%) of Co
Table 4: different formulations decontamination bag is right
131The absorption soil removal efficiency (%) of I
Embodiment 2, irritant experiment
1, wound irritant experiment:
New zealand rabbit, 8, male and female half and half, the back diamond wool is cut short the back unhairing, and each 3cm * 3cm about the unhairing scope is behind half rabbit skin degerming, rub with sand paper, the degree of being with the oozing of blood is divided into matched group (intact skin group I, damaged skin group II), experimental group (intact skin group III, damaged skin group IV), the artificial wound of making, get combined group decontamination solution 0.5ml (prescription of f) and directly be coated on the wound, with two layers of gauze (2.5cm * 2.5cm) cover with one deck cellophane, fixing, opposite side skin in contrast, smear negative control, apply 4h, after the off-test, remove residual given the test agent with warm water.Behind the removing given the test agent 1,24,48,72h observe the dermoreaction that gives the given the test agent position respectively, judge the wound stimulus intensity.Standard integral according to skin erythema, edema formation, wound recovery extent carries out the overall merit of decontamination solution stimulation.Total mark 0-3 is the I level, and 4-6 is the II level, and 7-9 is the III level.The rabbit acute skin irritation test shows: to the influence of new zealand rabbit wound skin surface healing, decontamination experimental group and normal saline matched group are at the wound stimulus intensity no significant difference (p＞0.05) of 1h, 24h, 48h and 72h.(referring to table 5)
Table 5: rabbit acute skin irritation test
Scope of the present invention is not subjected to the restriction of described specific embodiments, and described embodiment also comprises the method and the component of functional equivalent only as the single example of illustrating various aspects of the present invention in the scope of the invention.In fact, except content as herein described, those skilled in the art can easily grasp multiple improvement of the present invention with reference to above description and accompanying drawing.Described improvement also falls within the scope of appended claims.Every piece of list of references mentioned above is listed this paper in as a reference all in full.
Claims (10)
1. a radioactive skin contamination decontamination solution is characterized in that described radioactive skin contamination decontamination solution is the aqueous solution that contains 0.5-10%EDTA, 0.5-10% citric acid, the super sodium chloride of 0.5-10% and 0.5-10% sodium alkyl sulfate.
2. radioactive skin contamination decontamination bag as claimed in claim 1 is characterized in that described radioactive skin contamination decontamination solution can be the aqueous solution that contains 1-8%EDTA, 1-8% citric acid, the super sodium chloride of 1-8% and 1-8% sodium alkyl sulfate.
3. radioactive skin contamination decontamination bag as claimed in claim 1 is characterized in that described radioactive skin contamination decontamination solution can be the aqueous solution that contains 1.5-6%EDTA, 1.5-6% citric acid, the super sodium chloride of 3-6% and 3-6% sodium alkyl sulfate.
4. radioactive skin contamination decontamination bag as claimed in claim 1 is characterized in that described radioactive skin contamination decontamination solution can be the aqueous solution that contains 1.5-3%EDTA, 2-3% citric acid, the super sodium chloride of 4-6% and 5-6% sodium alkyl sulfate.
5. radioactive skin contamination decontamination bag that comprises the described radioactive skin contamination decontamination solution of claim 1.
6. radioactive skin contamination decontamination bag as claimed in claim 5 is characterized in that described radioactive skin contamination decontamination bag also comprises adsorptive pads.
7. radioactive skin contamination decontamination bag as claimed in claim 6 is characterized in that described adsorptive pads can be weaving fiber pad or non-woven fibre mat or sponge.
8. radioactive skin contamination decontamination bag as claimed in claim 6 is characterized in that described weaving fiber pad is medical husky cloth.
9. radioactive skin contamination decontamination bag as claimed in claim 6 is characterized in that described non-woven fibre mat is a non-woven fabrics.
10. radioactive skin contamination decontamination bag as claimed in claim 7 is characterized in that described sponge is a microporous sponge.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910201523A CN101732341A (en) | 2009-12-21 | 2009-12-21 | Washing-disinfecting liquid and disinfecting-washing bag thereof for radioactive skin contamination |
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| CN200910201523A CN101732341A (en) | 2009-12-21 | 2009-12-21 | Washing-disinfecting liquid and disinfecting-washing bag thereof for radioactive skin contamination |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499941A (en) * | 2011-10-20 | 2012-06-20 | 中国人民解放军海军医学研究所 | Decontamination bag for skin radioactive contamination |
| WO2012126198A1 (en) * | 2011-03-18 | 2012-09-27 | 南京维赛医药科技有限公司 | Acid-base neutralizing solution for chemical burning protection |
| CN106692180A (en) * | 2016-12-22 | 2017-05-24 | 珠海博纳百润生物科技有限公司 | Washing and disinfecting liquid used for emergency eye chemical burns, and preparation method thereof |
| CN108210514A (en) * | 2018-02-26 | 2018-06-29 | 上海市第六人民医院 | Wound irrigation liquid |
| CN109700826A (en) * | 2019-01-16 | 2019-05-03 | 中国人民解放军海军特色医学中心 | A kind of radionuclide contamination decontaminant and its preparation method and application |
| CN111855340A (en) * | 2020-06-09 | 2020-10-30 | 中国人民解放军火箭军特色医学中心 | Method for detecting decontamination efficiency of radioactive nuclide skin by decontamination device |
| CN112704646A (en) * | 2021-01-12 | 2021-04-27 | 中国人民解放军海军特色医学中心 | Decontamination wet tissue for radionuclide-infected skin and application thereof |
| US11600398B1 (en) | 2022-07-08 | 2023-03-07 | Giftedness And Creativity Company | Handheld device for removing radioactive spills |
-
2009
- 2009-12-21 CN CN200910201523A patent/CN101732341A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012126198A1 (en) * | 2011-03-18 | 2012-09-27 | 南京维赛医药科技有限公司 | Acid-base neutralizing solution for chemical burning protection |
| CN102499941A (en) * | 2011-10-20 | 2012-06-20 | 中国人民解放军海军医学研究所 | Decontamination bag for skin radioactive contamination |
| CN106692180A (en) * | 2016-12-22 | 2017-05-24 | 珠海博纳百润生物科技有限公司 | Washing and disinfecting liquid used for emergency eye chemical burns, and preparation method thereof |
| CN108210514A (en) * | 2018-02-26 | 2018-06-29 | 上海市第六人民医院 | Wound irrigation liquid |
| CN109700826A (en) * | 2019-01-16 | 2019-05-03 | 中国人民解放军海军特色医学中心 | A kind of radionuclide contamination decontaminant and its preparation method and application |
| CN109700826B (en) * | 2019-01-16 | 2021-05-14 | 中国人民解放军海军特色医学中心 | Radionuclide pollution decontamination agent and preparation method and application thereof |
| CN111855340A (en) * | 2020-06-09 | 2020-10-30 | 中国人民解放军火箭军特色医学中心 | Method for detecting decontamination efficiency of radioactive nuclide skin by decontamination device |
| CN112704646A (en) * | 2021-01-12 | 2021-04-27 | 中国人民解放军海军特色医学中心 | Decontamination wet tissue for radionuclide-infected skin and application thereof |
| US11600398B1 (en) | 2022-07-08 | 2023-03-07 | Giftedness And Creativity Company | Handheld device for removing radioactive spills |
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Open date: 20100616 |