WO2012122340A8 - Activateurs de guanylate cyclase solubles - Google Patents
Activateurs de guanylate cyclase solubles Download PDFInfo
- Publication number
- WO2012122340A8 WO2012122340A8 PCT/US2012/028205 US2012028205W WO2012122340A8 WO 2012122340 A8 WO2012122340 A8 WO 2012122340A8 US 2012028205 W US2012028205 W US 2012028205W WO 2012122340 A8 WO2012122340 A8 WO 2012122340A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- guanylate cyclase
- soluble guanylate
- cyclase activators
- processes
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12712176.2A EP2683710B1 (fr) | 2011-03-10 | 2012-03-08 | Activateurs de guanylate cyclase solubles |
JP2013557848A JP5715713B2 (ja) | 2011-03-10 | 2012-03-08 | 可溶性グアニル酸シクラーゼ活性化因子 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161451163P | 2011-03-10 | 2011-03-10 | |
US61/451,163 | 2011-03-10 | ||
US201161537741P | 2011-09-22 | 2011-09-22 | |
US61/537,741 | 2011-09-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012122340A1 WO2012122340A1 (fr) | 2012-09-13 |
WO2012122340A8 true WO2012122340A8 (fr) | 2013-04-25 |
Family
ID=45929608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/028205 WO2012122340A1 (fr) | 2011-03-10 | 2012-03-08 | Activateurs de guanylate cyclase solubles |
Country Status (4)
Country | Link |
---|---|
US (1) | US8569339B2 (fr) |
EP (1) | EP2683710B1 (fr) |
JP (1) | JP5715713B2 (fr) |
WO (1) | WO2012122340A1 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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BR122021013836B1 (pt) | 2009-12-04 | 2022-05-24 | Sunovion Pharmaceuticals, Inc. | Composto e seu uso, composição farmacêutica |
US8569339B2 (en) | 2011-03-10 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
WO2013025425A1 (fr) | 2011-08-12 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Activateurs de guanylate cyclase soluble |
SG11201408421TA (en) | 2012-07-20 | 2015-02-27 | Bayer Pharma AG | Novel 5-aminotetrahydroquinoline-2-carboxylic acids and use thereof |
NZ703989A (en) | 2012-09-07 | 2017-04-28 | Boehringer Ingelheim Int | Alkoxy pyrazoles as soluble guanylate cyclase activators |
MX2015006856A (es) * | 2012-11-30 | 2016-02-17 | Astellas Pharma Inc | Compuestos imidazopiridina. |
CA2923393A1 (fr) * | 2013-09-05 | 2015-03-12 | Glaxosmithkline Intellectual Property Development Limited | Nouveaux activateurs de guanylate cyclase soluble et leur utilisation |
WO2015095515A1 (fr) | 2013-12-20 | 2015-06-25 | Novartis Ag | Activateurs sgc pour le traitement de glaucome |
TW201625584A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
TW201625586A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 環己烯-1-基-吡啶-2-基-1h-吡唑-4-羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
TW201625601A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 噻吩-2-基-吡啶-2-基-1h-吡唑-4-羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
MX2017000926A (es) * | 2014-07-22 | 2017-05-04 | Boehringer Ingelheim Int | Acidos carboxilicos heterociclicos como activadores de guanilato ciclasa soluble. |
CN105980373A (zh) * | 2014-09-05 | 2016-09-28 | 葛兰素史密斯克莱知识产权发展有限公司 | 新的可溶性鸟苷酸环化酶活化剂及它们的用途 |
SG10201806809QA (en) | 2015-02-11 | 2018-09-27 | Sunovion Pharmaceuticals Inc | 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders |
US9809586B2 (en) | 2015-03-28 | 2017-11-07 | Wisconsin Alumni Research Foundation | Inhibitors of collagen prolyl 4-hydroxylase |
BR112018015718A2 (pt) * | 2016-02-01 | 2019-01-08 | Ironwood Pharmaceuticals Inc | utilização de estimuladores de sgc para o tratamento de esteato-hepatite não alcoólica (nash) |
JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 化合物および組成物ならびにそれらの使用 |
MX2019000980A (es) | 2016-07-29 | 2019-07-04 | Sunovion Pharmaceuticals Inc | Compuestos y composiciones y usos de los mismos. |
JP7237823B2 (ja) | 2016-10-11 | 2023-03-13 | バイエル ファーマ アクチエンゲゼルシャフト | Sgcアクチベーターとミネラルコルチコイド受容体アンタゴニストとを含む組合せ |
JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
MX2020000523A (es) | 2017-08-02 | 2020-08-20 | Sunovion Pharmaceuticals Inc | Compuestos de isocromano y usos de los mismos. |
WO2019081456A1 (fr) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | Utilisation d'activateurs et de stimulateurs de sgc comprenant une sous-unité bêta2 |
EP3498298A1 (fr) | 2017-12-15 | 2019-06-19 | Bayer AG | Utilisation de stimulateurs sgc et d'activateurs sgc seuls ou en combinaison avec des inhibiteurs pde5 pour le traitement de troubles osseux, y compris l'ostéogénèse imparfaite (oi) |
CN118406063A (zh) | 2018-02-16 | 2024-07-30 | 赛诺维信制药公司 | 盐、晶型及其制备方法 |
EP3787610A1 (fr) | 2018-04-30 | 2021-03-10 | Bayer Aktiengesellschaft | Utilisation d'activateurs de la gcs et de stimulateurs de la gcs pour le traitement de déficiences cognitives |
BR112020022340A2 (pt) | 2018-05-15 | 2021-02-02 | Bayer Aktiengesellschaft | benzamidas substituídas por 1,3-tiazol-2-il para o tratamento de doenças associadas com sensibilização de fibras nervosas |
EP3574905A1 (fr) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Procédé d'identification d'un sous-groupe de patients souffrant de dcssc qui bénéficie d'un traitement comportant des stimulateurs sgc et des activateurs sgc à un degré supérieur à celui d'un groupe de contrôle |
CN113330030A (zh) | 2019-01-17 | 2021-08-31 | 拜耳公司 | 确定受试者是否适于用可溶性鸟苷酸环化酶(sGC)的激动剂治疗的方法 |
US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
EP4010333A1 (fr) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Inhibiteurs de la kallicréine plasmatique |
TW202120478A (zh) * | 2019-11-22 | 2021-06-01 | 美商富曼西公司 | 用於合成(3-氯-2-吡啶基)肼的新穎製程 |
JP7312120B2 (ja) * | 2020-01-22 | 2023-07-20 | 公益財団法人相模中央化学研究所 | N-(ジフルオロヨードメチル)イミダゾール類及びその製造方法 |
MX2022012833A (es) | 2020-04-14 | 2022-11-07 | Sunovion Pharmaceuticals Inc | (s)-(4,5-dihidro-7h-tieno[2,3-c]piran-7-il)-n-metilmetanamina para tratar trastornos neurologicos y psiquiatricos. |
CN112079781B (zh) * | 2020-09-30 | 2022-11-22 | 苏州康润医药有限公司 | 5-溴-1-甲基-1h-吡唑-3-胺的合成方法 |
TW202412753A (zh) | 2022-06-09 | 2024-04-01 | 德商拜耳廠股份有限公司 | 用於治療女性心臟衰竭合併保留射出分率的可溶性鳥苷酸環化酶活化劑 |
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AU2002214626A1 (en) | 2000-09-29 | 2002-04-08 | Cor Therapeutics, Inc. | Quaternary amines and related inhibitors of factor xa |
MX2008000779A (es) | 2005-07-18 | 2008-02-21 | Bayer Healthcare Ag | Uso de activadores y estimuladores de guanilatociclasa solubles para la prevencion o tratamiento de trastornos renales. |
US20080045560A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Pyrrolidine and related derivatives useful as PR modulators |
EP2144605A1 (fr) | 2007-05-12 | 2010-01-20 | Bayer HealthCare AG | Stimulateurs de la sgc, activateurs de la sgc et combinaisons pour le traitement de troubles urologiques |
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KR20100063109A (ko) | 2007-10-05 | 2010-06-10 | 사노피-아벤티스 도이칠란트 게엠베하 | 통증 치료에서 설포닐-치환된 2-설포닐아미노벤조산 n-페닐아미드의 용도 |
FR2923907B1 (fr) * | 2007-11-16 | 2010-01-08 | Snr Roulements Sa | Jauge de contrainte pour mesurer des deformations longitudinales et transversales |
WO2009068652A1 (fr) | 2007-11-30 | 2009-06-04 | Smithkline Beecham Corporation | Pyridines 2, 6-disubstituées et pyrimidines 2, 4-disubstituées en tant qu'activateurs de guanylate cyclase soluble |
UY31507A1 (es) | 2007-12-03 | 2009-07-17 | Derivados de piridina activadores de guanilato ciclasa soluble | |
WO2010015652A2 (fr) | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Composés thiazole utilisés comme activateurs de la guanylate cyclase soluble |
WO2010015653A1 (fr) | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Dérivés de pyrimidine comme activateurs de guanylate cyclase soluble |
EP2373317B1 (fr) | 2008-11-25 | 2016-12-14 | Merck Sharp & Dohme Corp. | Dérivés de 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one ou 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one en tant qu'activateurs de la cyclase du guanylat soluble pour le traitement de maladies cardio-vasculaires |
JP5780430B2 (ja) | 2009-01-17 | 2015-09-16 | アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 勃起不全の処置用のPDE5阻害剤と組み合わせたsGC刺激剤またはsGC活性化剤 |
MX2011008952A (es) | 2009-02-26 | 2011-09-27 | Merck Sharp & Dohme | Activadores de guanilato ciclasa solubles. |
WO2011161099A1 (fr) * | 2010-06-25 | 2011-12-29 | Bayer Pharma Aktiengesellschaft | Utilisation de stimulateurs et d'activateurs de la guanylate-cyclase soluble pour le traitement de la drépanocytose et la conservation de substituts sanguins |
EP2632551B1 (fr) | 2010-10-28 | 2016-07-06 | Merck Sharp & Dohme Corp. | Activateurs de la guanylate cyclase soluble |
US8569339B2 (en) | 2011-03-10 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
WO2013025425A1 (fr) | 2011-08-12 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Activateurs de guanylate cyclase soluble |
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2012
- 2012-03-08 US US13/414,991 patent/US8569339B2/en active Active
- 2012-03-08 EP EP12712176.2A patent/EP2683710B1/fr active Active
- 2012-03-08 WO PCT/US2012/028205 patent/WO2012122340A1/fr active Application Filing
- 2012-03-08 JP JP2013557848A patent/JP5715713B2/ja active Active
Also Published As
Publication number | Publication date |
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WO2012122340A1 (fr) | 2012-09-13 |
EP2683710B1 (fr) | 2017-07-19 |
US20130065918A1 (en) | 2013-03-14 |
JP2014507478A (ja) | 2014-03-27 |
US8569339B2 (en) | 2013-10-29 |
EP2683710A1 (fr) | 2014-01-15 |
JP5715713B2 (ja) | 2015-05-13 |
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