WO2012105640A1 - 容器兼用注射器 - Google Patents

容器兼用注射器 Download PDF

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Publication number
WO2012105640A1
WO2012105640A1 PCT/JP2012/052359 JP2012052359W WO2012105640A1 WO 2012105640 A1 WO2012105640 A1 WO 2012105640A1 JP 2012052359 W JP2012052359 W JP 2012052359W WO 2012105640 A1 WO2012105640 A1 WO 2012105640A1
Authority
WO
WIPO (PCT)
Prior art keywords
bypass chamber
front stopper
outer cylinder
syringe
stopper
Prior art date
Application number
PCT/JP2012/052359
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
誠 垣内
島崎　誠二
Original Assignee
株式会社アルテ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社アルテ filed Critical 株式会社アルテ
Priority to CA2826222A priority Critical patent/CA2826222A1/en
Priority to EP12741652.7A priority patent/EP2671604B1/de
Priority to US13/983,298 priority patent/US9636463B2/en
Priority to CN2012800070357A priority patent/CN103338798A/zh
Publication of WO2012105640A1 publication Critical patent/WO2012105640A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A61M2005/287—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the present invention relates to a container-use syringe that is pre-filled with a chemical solution and can be used immediately after being taken out of the package at the time of use.
  • This application claims priority based on Japanese Patent Application No. 2011-21006 for which it applied to Japan on February 2, 2011, and uses the content here.
  • the container / syringe Since the container / syringe is pre-filled with a chemical solution, it can be taken out of the package and used immediately without any complicated operation in a medical institution. As described above, since the container-use syringe is excellent in convenience, it greatly reduces the work of persons involved in medical work such as doctors and nurses, and is therefore adopted in many hospitals.
  • this container combined syringe there are an outer cylinder, a front stopper and an end stopper that are fitted from the front and rear end sides into the outer cylinder and seal the liquid medicine filled in the outer cylinder in a liquid-tight manner, and the tip of the outer cylinder Is fitted from the outside into a bypass chamber into which a front stopper is inserted, a tube tip provided with a luer tip for attaching an injection needle at the tip thereof, a finger grip fitted from the outside to the rear end of the outer tube, and an outer tube
  • a plunger rod that is inserted into an outer cylinder from the rear end portion and connected to an end stopper (see, for example, Patent Document 1).
  • the front stopper moves forward together with the drug solution by pushing the end stopper into the outer cylinder by the plunger rod. Then, when the front stopper is pushed out from the outer cylinder and enters the bypass chamber at the end of the cylinder, the front end side sealing in the chemical solution sealed between the front stopper and the end stopper is released. As a result, the drug solution flows out from the outer cylinder into the bypass chamber, is guided to the inner surface of the lure tip along the bypass groove provided on the inner peripheral surface of the bypass chamber, and is guided to the injection needle.
  • the width of the bypass groove through which the chemical solution and bubbles pass is made as small as possible in order to reduce the residual amount of the chemical solution in the bypass groove.
  • the plunger rod is pushed into the outer cylinder to try to discharge the bubbles to the outside
  • the chemical liquid below the bubbles enters the bypass groove prior to some of the bubbles remaining above.
  • the drug solution closes the passage of the bubbles, so that a part of the bubbles may remain dispersed in the bypass groove and may be mixed with the drug solution to be injected later and injected into the patient's body.
  • the present invention has been made in view of such a problem, and an object of the present invention is to provide a container and syringe that can effectively remove bubbles in a chemical solution.
  • the present invention proposes the following means. That is, the container-use syringe according to the present invention is fitted into a cylindrical outer cylinder extending along the axis, a front stopper fitted into the distal end side in the outer cylinder, and a rear end side in the outer cylinder.
  • the end stopper that seals the chemical solution between the front stopper and the front end of the outer cylinder is fitted to the front end of the outer cylinder through the fitting hole on the base end side, and the front stopper is accommodated on the front end side of the fitting hole.
  • the inner diameter of the bypass chamber is formed larger than the outer diameter of the front stopper.
  • the inner circumferential surface of the bypass chamber having a circular cross section projects radially inward and extends over the entire axial direction of the bypass chamber, and can be in close contact with the outer circumferential surface of the front stopper moved into the bypass chamber.
  • a plurality of ribs are provided at intervals in the circumferential direction.
  • the container / use injector When air bubbles are removed in the container / use syringe having such characteristics, the container / use injector is held with the tip side of the container / use syringe facing upward. Thereby, the bubbles in the chemical liquid are concentrated on the upper surface of the chemical liquid.
  • the front stopper When the front stopper is moved forward together with the end stopper by pushing the plunger rod into the outer cylinder in this state, the front stopper fitted in the outer cylinder moves into the bypass chamber. At this time, if the rib formed on the bypass chamber is in close contact with the front stopper and the front stopper is supported in the bypass chamber, the radial direction between the outer peripheral surface of the front stopper and the inner peripheral surface of the bypass chamber A chemical distribution space having a uniform dimension over the circumferential direction is formed.
  • the medicinal solution circulation space extending in the circumferential direction is formed between the inner peripheral surface of the bypass chamber and the outer peripheral surface of the front stopper, the medicinal solution can be passed through the medicinal solution circulation space. Bubbles can be discharged to the outside without being affected by the surface tension. This makes it possible to effectively remove bubbles in the chemical solution.
  • FIG. 2 is an enlarged view of a tube tip in FIG. 1.
  • FIG. 4 is a cross-sectional view taken along line AA in FIG. 3. It is a figure which shows the modification of the linear rib of the container combined use syringe which concerns on embodiment of this invention. It is a figure which shows the modification of the linear rib of the container combined use syringe which concerns on embodiment of this invention. It is sectional drawing orthogonal to the axis line in a bypass chamber, Comprising: It is a figure explaining the state which the front stopper moved in the bypass chamber.
  • FIG. 7 is a sectional view taken along line BB in FIG. It is an enlarged view of the tube tip in the container combined use syringe of the 2nd modification of the present invention. It is sectional drawing orthogonal to the axis line in the bypass chamber of the conventional container combined use syringe, Comprising: It is a figure explaining the state which the front stopper moved in the bypass chamber.
  • the container-use syringe 1 includes an outer cylinder 10, a cylinder tip 50 attached to the distal end side (left side in FIG. 1), and an outer periphery on the rear end side (right side in FIG. 1) of the outer cylinder 10.
  • a finger grip 20 fitted from the outside, a front stopper 30 for sealing the chemical M filled in the outer cylinder 10 from the front end side, an end stopper 40 for sealing from the rear end side, and the inside of the outer cylinder 10.
  • a plunger rod 25 that is inserted from the rear end side, is connected to the end stopper 40, and reciprocates the end stopper 40 in the direction of the axis O of the outer cylinder 10 is provided.
  • the outer cylinder 10 is made of transparent glass and has a cylindrical shape extending along the axis O.
  • the inside of the outer cylinder 10 is filled with a chemical M, the front end side is sealed by the front stopper 30, and the rear end side is the end. Sealed by a stopper 40.
  • a ring-shaped protrusion 11 is provided on the outer periphery of the rear end of the outer cylinder 10, and the ring-shaped protrusion 11 is fitted into a ring-shaped groove 21 formed in the cylindrical hole of the finger grip 20, whereby the finger grip 20 Is firmly fixed to the outer cylinder 10.
  • the finger grip 20 may be formed integrally with the outer cylinder 10 in addition to the structure separately attached to the outer cylinder 10.
  • the front stopper 30 has a substantially cylindrical shape centered on the axis O, and is formed of a medical rubber that has corrosion resistance against the drug solution M.
  • an annular convex portion 32 that protrudes radially outward and an annular concave portion 33 that annularly recesses radially inwardly extend in the axis O direction over the entire circumference of the outer peripheral surface 31. They are formed alternately and continuously.
  • the front stopper 30 of the present embodiment has three annular convex portions 32 that are spaced apart in the direction of the axis O, and has a total of two annular concave portions 33 that are respectively formed between the annular convex portions 32. .
  • the outer diameter of the annular protrusion 32 is referred to as the outer diameter of the front stopper 30.
  • the front stopper 30 is liquid-tightly inserted into the outer cylinder 10 so as to be positioned at the distal end side in the outer cylinder 10 when the container-use syringe 1 is not used. That is, the outer diameter of the front stopper 30 is larger than the inner diameter of the outer cylinder 10 and is compressed from the inner peripheral surface 73 of the outer cylinder 10 when fitted into the outer cylinder 10. In this state, the diameter is smaller than the original outer diameter.
  • the end stopper 40 has a substantially cylindrical shape with the axis O as the center, and is formed of a medical rubber that has corrosion resistance against the drug solution M.
  • the end stopper 40 is liquid-tightly fitted into the outer cylinder 10 so as to be positioned on the rear end side in the outer cylinder 10.
  • a drug solution M to be administered to a patient is sealed between the end stopper 40 and the front stopper 30 in the outer cylinder 10.
  • the plunger rod 25 is inserted into the outer cylinder 10 from the rear end side of the outer cylinder 10, and the tip is connected to the end stopper 40.
  • the tube tip 50 has an outer shape multistage columnar shape made of a transparent synthetic resin having appropriate rigidity, and has a base end portion 60 having a cylindrical shape and a tip end of the base end portion 60.
  • a cylindrical portion 70 coupled so as to be reduced in diameter by one step on the side, and a luer tip 80 formed to have a smaller diameter than the cylindrical portion 70 on the distal end side of the cylindrical portion 70 are provided.
  • a fitting hole 61 that opens to the rear end side of the tube tip 50 is formed inside the base end portion 60, and a bottomed circle is formed on the distal end side of the fitting hole 61, that is, inside the cylindrical portion 70.
  • a hole-shaped bypass chamber 71 is formed. Note that a surface facing the rear end side of the bypass chamber 71 is a bottom portion 72 with which a front stopper 30 described later comes into contact.
  • an introduction hole 81 that penetrates the luer tip 80 along the axis O is formed in the luer tip 80. That is, the introduction hole 81 has one end opened at the center of the bottom 72 of the bypass chamber 71 and the other end opened at the tip of the luer tip 80.
  • An injection needle (not shown) extending toward the distal end side along the axis O is attached to the introduction hole 81 in a communicating state.
  • the cover 2 that covers the tube tip 50 (the luer tip 80) is attached to the tip of the tube tip 50.
  • the fitting hole 61 is a hole formed for attaching the tube tip 50 to the outer cylinder 10, and has an inner diameter substantially the same as the outer diameter of the outer cylinder 10. By fitting the fitting hole 61 from the outside to the distal end of the outer cylinder 10, the cylinder tip 50 is attached to the distal end side of the outer cylinder 10.
  • a ring-shaped groove 62 centering on the axis O is formed at the front end portion of the inner peripheral wall of the fitting hole 61.
  • the ring-shaped protrusion 12 is formed on the outer periphery of the outer cylinder 10, and when the cylinder tip 50 is attached to the distal end side of the outer cylinder 10, the ring-shaped protrusion 12 is fitted into the ring-shaped groove 62, thereby causing the cylinder tip 50. Is firmly fixed to the outer cylinder 10.
  • the bypass chamber 71 has a bottomed hole in which the inner peripheral surface 73 has an inner diameter that is one step smaller than the fitting hole 61.
  • the inner diameter of the inner peripheral surface 73 of the bypass chamber 71 is essentially the outer diameter of the outer peripheral surface 31 of the front stopper 30, that is, the state in which the front stopper 30 is not fitted into the outer cylinder 10. It is formed larger than the outer diameter.
  • a plurality of linear ribs projecting inward in the radial direction and extending linearly over the entire region in the axis O direction of the bypass chamber 71 on the inner peripheral surface 73 of the bypass chamber 71.
  • (Rib) 74 is formed.
  • These linear ribs 74 extend in parallel to the axis O and are arranged at intervals in the circumferential direction.
  • a total of four linear ribs 74 are formed at intervals of 90 ° in the circumferential direction.
  • at least three straight ribs 74 are preferably formed, and more preferably within eight.
  • the plurality of linear ribs 74 are preferably arranged at equal intervals in the circumferential direction.
  • the height of the linear rib 74 from the inner peripheral surface 73 of the bypass chamber 71, that is, the radial dimension of the linear rib 74 is preferably set to 0.05 to 0.45 mm. Further, the circumferential width of the linear rib 74 is preferably set to 0.3 to 0.1 mm. In the case of the present embodiment, as shown in FIG. 4A, at least the tip of the straight rib 74 in the cross section perpendicular to the axis O has an arc shape. However, for example, as shown in FIG. 4B or FIG.
  • At least the tip of the straight rib 74 in the cross section orthogonal to the axis O has a triangular shape or diameter that protrudes radially inward from the inner peripheral surface 73 of the bypass chamber 71.
  • You may comprise the trapezoid shape which becomes narrow toward the inner side in the direction.
  • annular ring groove 75 extending in the circumferential direction about the axis O is formed near the boundary between the bypass chamber 71 and the fitting hole 61 on the inner peripheral surface 73 of the bypass chamber 71.
  • the annular grooves 75 are connected to the rear ends of the plurality of linear ribs 74, respectively.
  • a plurality of radial grooves 76 extending radially outward from the opening of the introduction hole 81 formed at the center of the bottom portion 72 are formed in the bottom portion 72 of the bypass chamber 71.
  • the radially outer end of the radial groove 76 is connected to the inner peripheral surface 73 of the bypass chamber 71.
  • a plurality of radial grooves 76 are arranged at equal intervals in the circumferential direction.
  • a total of four radial grooves 76 are formed at intervals of 90 ° in the circumferential direction.
  • the linear rib 74 and the radial groove 76 of the present embodiment are in a positional relationship shifted by 45 ° in the circumferential direction when viewed from the direction of the axis O.
  • the outer diameter of the front stopper 30 (the outer diameter of the annular convex portion 32) is set to D ⁇ [1+ (4.5 to 7.5%)] mm, for example. It is preferable. Further, the inner diameter of the inner peripheral surface 73 of the bypass chamber 71 is preferably set to D + (0.8 to 1.7) mm.
  • a bubble removing operation for removing bubbles remaining in the drug solution M is performed.
  • the container-use syringe 1 is first held with the injection needle attached to the luer tip 80 and the tip side facing upward. Thereby, the bubbles in the chemical liquid M concentrate on the upper part of the chemical liquid M, that is, near the rear end surface of the front stopper 30.
  • a chemical solution circulation space 90 having a substantially uniform radial dimension in the circumferential direction is formed.
  • the medicinal solution circulation space 90 exists over a region where the straight ribs 74 in the circumferential direction of the bypass chamber 71 are not formed, that is, a total of four over a range of approximately 90 ° in the circumferential direction between the adjacent straight ribs 74.
  • One chemical solution distribution space 90 is formed.
  • the air bubbles thus introduced into the drug solution circulation space 90 move extremely naturally along the inner peripheral surface 73 of the bypass chamber 71 toward the upper part of the syringe 1 serving as a container, that is, to release the air bubbles to the outside. Even if the plunger rod 25 is not pushed further into the outer cylinder 10, the bubbles can be easily moved to the distal end side of the container-use syringe 1. Then, the bubbles are discharged to the outside of the container-use syringe 1 through an introduction hole 81 formed in the bottom 72 of the bypass chamber 71 and an injection needle communicating with the introduction hole 81.
  • the medicinal solution circulation space 90 existing in the circumferential direction is formed between the inner peripheral surface 73 of the bypass chamber 71 and the outer peripheral surface 31 of the front stopper 30. Therefore, the bubbles can be released to the outside without being affected by the surface tension of the chemical liquid M through the chemical liquid circulation space 90. Thereby, it is possible to effectively remove bubbles in the chemical liquid M.
  • the example in which the radial groove 76 is formed in the bottom 72 of the bypass chamber 71 has been described.
  • the bottom 72 of the bypass chamber 71 Radial ribs 78 extending in the radial direction continuously from the tips of the plurality of linear ribs 74 may be formed.
  • a plurality of the radial ribs 78 are formed at intervals in the circumferential direction like the linear ribs 74, and the radially inner end portion is connected to the opening of the introduction hole 81.
  • the example which formed the linear rib 74 in the internal peripheral surface 73 of the bypass chamber 71 was demonstrated, it is not limited to this,
  • the spiral rib 77 may be formed on the inner peripheral surface 73 of the bypass chamber 71.
  • the spiral rib 77 forms a spiral that twists in the circumferential direction toward the one side in the axis O direction.
  • the chemical solution circulation space 90 can be formed between the adjacent spiral ribs 77. It can lead to the outside more smoothly.
  • the shape and dimensions of the front stopper 30 are the inner peripheral surface of the outer cylinder 10 and the inner peripheral surface of the bypass chamber 71 in order to improve the slidability in the outer cylinder 10 and to facilitate the removal of bubbles. It is preferable that the shape of the radially outer tip of the annular convex portion 32 in contact with 73 be as small as possible as long as the airtightness as the container-use syringe 1 can be maintained.
  • the number of the annular protrusions 32 is preferably set to 2 to 5 so that the front stopper 30 can maintain the correct posture in the outer cylinder 10 and the bypass chamber 71. Furthermore, it is preferable to set the outer diameter of the annular recess 33 as large as possible within a range that does not contact the inner peripheral surface of the outer cylinder 10 and the inner peripheral surface 73 of the bypass chamber 71. Thereby, when the front stopper 30 moves into the bypass chamber 71, the amount of the chemical M remaining in the annular recess 33 can be reduced.
  • FIG. 9 is a cross-sectional view orthogonal to the axis of the bypass chamber of the conventional container-use syringe, and is a view for explaining a state in which the front stopper has moved into the bypass chamber. That is, this figure shows a situation similar to that of FIG. 5 in the conventional container / use syringe 1 of the present invention.
  • reference numeral 130 denotes a front stopper, which corresponds to the front stopper 30 in the present invention.
  • Reference numeral 170 denotes a cylindrical portion at the end of the tube, which corresponds to the cylindrical portion 70 in the present invention.
  • the inner circumferential surface 173 of the bypass chamber formed inside the cylindrical portion 70 is recessed toward the radially outer side and extends linearly over the entire axial direction of the bypass chamber.
  • the bypass groove 174 is formed. In the example of FIG. 9, a total of four bypass grooves 174 are formed at intervals of 90 ° in the circumferential direction.
  • the medicinal solution is guided to the injection needle through a medicinal solution circulation space 190 formed by a gap formed between the inner peripheral surface 173 of the bypass chamber and the outer peripheral surface 131 of the front stopper 130 and the bypass groove 174.
  • the cross-sectional area in FIG. 9 (cross-sectional area perpendicular to the axis of the bypass chamber) of the drug solution circulation space 190 in the conventional container-use syringe is S1
  • the drug solution distribution space 90 in the container-use syringe 1 of the present invention is shown in FIG.
  • S1 is the 1.9 ⁇ 2.8mm 2
  • S2 was 8.5 ⁇ 11.0 mm 2.
  • the cross-sectional area S1 of the drug solution circulation space 190 with respect to the cross-sectional area in FIG. 9 of the front stopper 130 (cross-sectional area perpendicular to the axis of the bypass chamber) in the conventional container-use syringe is 1.6 to 4.5%
  • the ratio of the 90 cross-sectional area S2 was 5.0 to 26.3%. Also in this case, if the above ratio is less than 5.0%, residual bubbles are observed in the bypass chamber, and if it exceeds 26.3%, the amount of the chemical remaining in the bypass chamber increases, which is a practical problem. Was confirmed to occur.
  • the bubbles in the drug solution can be effectively removed by releasing the bubbles in the drug solution to the outside without being affected by the surface tension of the drug solution filled in the container. Is possible.
PCT/JP2012/052359 2011-02-02 2012-02-02 容器兼用注射器 WO2012105640A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2826222A CA2826222A1 (en) 2011-02-02 2012-02-02 Combination container/syringe
EP12741652.7A EP2671604B1 (de) 2011-02-02 2012-02-02 Kombinationsbehälter/-spritze
US13/983,298 US9636463B2 (en) 2011-02-02 2012-02-02 Combination container/syringe
CN2012800070357A CN103338798A (zh) 2011-02-02 2012-02-02 兼用作容器的注射器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011021006A JP4934226B1 (ja) 2011-02-02 2011-02-02 容器兼用注射器
JP2011-021006 2011-02-02

Publications (1)

Publication Number Publication Date
WO2012105640A1 true WO2012105640A1 (ja) 2012-08-09

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ID=46395289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/052359 WO2012105640A1 (ja) 2011-02-02 2012-02-02 容器兼用注射器

Country Status (6)

Country Link
US (1) US9636463B2 (de)
EP (1) EP2671604B1 (de)
JP (1) JP4934226B1 (de)
CN (1) CN103338798A (de)
CA (1) CA2826222A1 (de)
WO (1) WO2012105640A1 (de)

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CN103338798A (zh) 2013-10-02
JP4934226B1 (ja) 2012-05-16
EP2671604B1 (de) 2017-08-23
EP2671604A1 (de) 2013-12-11
CA2826222A1 (en) 2012-08-09
EP2671604A4 (de) 2015-04-01
US9636463B2 (en) 2017-05-02
US20140048432A1 (en) 2014-02-20
JP2012157640A (ja) 2012-08-23

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