WO2012067136A1 - 4-カルボニルオキシキノリン誘導体の製造方法 - Google Patents
4-カルボニルオキシキノリン誘導体の製造方法 Download PDFInfo
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- WO2012067136A1 WO2012067136A1 PCT/JP2011/076370 JP2011076370W WO2012067136A1 WO 2012067136 A1 WO2012067136 A1 WO 2012067136A1 JP 2011076370 W JP2011076370 W JP 2011076370W WO 2012067136 A1 WO2012067136 A1 WO 2012067136A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Definitions
- the present invention relates to a method for producing 4-carbonyloxyquinoline derivatives useful as agricultural chemicals.
- Patent Document 1 4-Carbonyloxyquinoline derivatives are disclosed in International Publication No. 2006/013896 (Patent Document 1), Japanese Unexamined Patent Application Publication No. 2008-110953 (Patent Document 2), and International Publication No. 2007/088978 (Patent Document 3).
- Patent Document 2 Japanese Unexamined Patent Application Publication No. 2008-110953
- Patent Document 3 International Publication No. 2007/088978
- These 4-carbonyloxyquinoline derivatives have high insecticidal activity against Lepidoptera, Hemiptera, Coleoptera, Mites, Hymenoptera, Diptera, Diptera, Thripidae, and plant parasitic nematodes It is a compound which shows.
- the 4-carbonyloxyquinoline derivative is effective as an agricultural and horticultural fungicide against various phytopathogenic fungi. It is known as a compound that exhibits a bactericidal effect against pathogenic fungi, peach aspergillus fungi, and strawberry anthracnose fungi.
- a method for producing the 4-carbonyloxyquinoline derivative is disclosed in International Publication No. 2010/007964 (Patent Document 4).
- the present inventors use a base that is inexpensive and easy to handle by using a phase transfer catalyst in the reaction of a quinolone derivative with a halogen compound or an acid anhydride. This makes it possible to apply a reaction solvent that does not require strict base charge equivalent management and that can be easily distilled off. An efficient manufacturing method was found. The present invention is based on these findings.
- an object of the present invention is to provide an industrially advantageous method for producing a 4-carbonyloxyquinoline derivative.
- a 4-carbonyloxyquinoline derivative of the general formula (1) is provided. That is, according to the present invention, a 4-carbonyloxyquinoline derivative of the general formula (1): [Where, R 1, R 2 and R 3 independently of one another, a hydrogen atom, a halogen atom, optionally substituted by halogen atom C 1-4 alkyl group or optionally substituted by halogen atom, C 1-4 Represents an alkoxy group, provided that R 1 , R 2 and R 3 do not represent a hydrogen atom at the same time; R 4 and R 5 independently of each other represent a hydrogen atom or a C 1-4 alkyl group which may be substituted with a halogen atom, provided that R 4 and R 5 do not represent a hydrogen atom at the same time, Or R 4 and R 5 together represent — (CH 2 ) m— (where m represents 3 or 4); R 6 , R 7 , R 8 , R 9 and R 10 are each
- OR 12 (wherein R 12 is a C 1-8 alkyl group which may be substituted with a halogen atom, a C 3-6 cyclic alkyl group which may be substituted with a halogen atom, or a halogen atom) represents an C 2-4 alkenyl group optionally), SR 13 (wherein, R 13 is optionally C 1-8 alkyl group optionally substituted by a halogen atom, optionally substituted by halogen atoms C 3 -6 represents a cyclic alkyl group, or a C 2-4 alkenyl group optionally substituted by a halogen atom.
- halogen atom means fluorine, chlorine, bromine or iodine, preferably fluorine, chlorine or bromine, more preferably chlorine or fluorine.
- cyclic alkyl group means that the alkyl group contains at least one cyclic structure.
- examples of the cyclic alkyl group include a cycloalkyl group, an alkyl group substituted with one or more cycloalkyl groups, and these may be further substituted with one or more alkyl groups.
- the C 1-4 alkyl group represented by R 1 , R 2 and R 3 may be linear or branched.
- the C 1-4 alkyl group is preferably a straight chain C 1-4 alkyl group, and examples thereof include a methyl group, an ethyl group, a propyl group, and an n-butyl group, and more preferably a methyl group or an ethyl group. Is done.
- the C 1-4 alkyl group represented by R 1 , R 2 and R 3 may be substituted with a halogen atom.
- Examples of the C 1-4 alkyl group substituted by a halogen atom represented by R 1 , R 2 and R 3 include a chloromethyl group, a trichloromethyl group, a trifluoromethyl group, and (1- or 2-) chloroethyl.
- the C 1-4 alkyl group represented by R 1 , R 2 and R 3 may be substituted with a C 1-4 alkoxy group.
- Examples of the C 1-4 alkyl group substituted by the C 1-4 alkoxy group represented by R 1 , R 2 and R 3 include a methoxymethyl group.
- the C 1-4 alkoxy group represented by R 1 , R 2 and R 3 may be linear or branched.
- a methoxy group, an ethoxy group, an n-propyloxy group, an i-propyloxy group examples include n-butyloxy group, i-butyloxy group, s-butyloxy group, and t-butyloxy group.
- the C 1-4 alkoxy group is preferably a straight chain C 1-4 alkoxy group, and examples thereof include a methoxy group, an ethoxy group, an n-propyloxy group, and an n-butyloxy group, and more preferably a methoxy group. Or an ethoxy group.
- the C 1-4 alkoxy group represented by R 1 , R 2 and R 3 may be substituted with a halogen atom.
- Examples of the C 1-4 alkoxy group represented by R 1 , R 2 and R 3 substituted with a halogen atom include a trifluoromethoxy group, a trichloromethoxy group, a difluoromethoxy group, a dichloromethoxy group, 2,2, Examples include 2-trifluoroethoxy group, 2,2,2-trichloroethoxy group, 1,1,2,2-tetrafluoroethoxy group, pentafluoroethoxy group, and pentachloroethoxy group.
- R 1 , R 2 and R 3 are independently of one another hydrogen, chlorine, bromine, fluorine, methyl, ethyl, methoxy, ethoxy, or tri Represents a fluoromethyl group (wherein R 1 , R 2 and R 3 do not represent a hydrogen atom at the same time), more preferably any one of R 1 , R 2 and R 3 is a methyl group, trifluoro It represents a methyl group or a methoxy group, and the remaining two represent a hydrogen atom. Particularly preferably, any one of R 1 and R 2 represents a methyl group, a trifluoromethyl group, or a methoxy group, the other is a hydrogen atom, and R 3 is a hydrogen atom.
- the C 1-4 alkyl group represented by R 4 and R 5 may be linear or branched.
- the C 1-4 alkyl group represented by R 4 and R 5 may be substituted with a halogen atom.
- Examples of the C 1-4 alkyl group substituted by a halogen atom represented by R 4 and R 5 include a chloromethyl group, a trichloromethyl group, a trifluoromethyl group, a (1- or 2-) chloroethyl group, 2 , 2,2-trifluoroethyl group, 1,1,2,2-tetrafluoroethyl group, and pentafluoroethyl group.
- the C 1-4 alkyl group represented by R 4 and R 5 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- R 4 and R 5 represent, as the C 1-4 alkyl group substituted by optionally C 1-4 alkoxy group optionally substituted by a halogen atom, for example, 2-trifluoromethoxy-ethyl.
- R 4 and R 5 independently of one another represent a hydrogen atom or a C 1-4 alkyl group optionally substituted by a halogen atom, provided that R 4 and R 5 Do not represent hydrogen atoms at the same time.
- R 4 and R 5 independently of one another represent a C 1-4 alkyl group which may be substituted by a halogen atom.
- the C 1-4 alkyl group in these embodiments is preferably a straight chain C 1-4 alkyl group.
- R 4 represents -CH 2 -R 14, R 5 represents R 14, R 14 represents a C 1-3 alkyl group.
- the C 1-3 alkyl group represented by R 14 may be linear or branched, but is preferably a linear C 1-3 alkyl group, more preferably a methyl group.
- the C 1-8 alkyl group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched, for example, methyl group, ethyl group, propyl group, i-propyl Group, n-butyl group, i-butyl group, s-butyl group, t-butyl group, n-pentyl group, (2- or 3-methyl) pentyl group, (2,3-, 2,4- or 3) , 4-dimethyl) butyl group, 2,3,4-trimethylpropyl group, n-heptyl group, and n-octyl group, preferably a methyl group or an ethyl group.
- the C 1-8 alkyl group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 1-8 alkyl group substituted by a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a chloromethyl group, a trichloromethyl group, a trifluoromethyl group, (1 -Or 2-) chloroethyl group, 2,2,2-trifluoroethyl group, 1,1,2,2-tetrafluoroethyl group, and pentafluoroethyl group are mentioned, preferably trifluoromethyl group, or penta Fluoroethyl group.
- the C 1-8 alkyl group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- Examples of the C 1-8 alkyl group represented by R 6 , R 7 , R 8 , R 9 and R 10 and substituted with a C 1-4 alkoxy group optionally substituted with a halogen atom include 2- A trifluoromethoxyethyl group is mentioned.
- the C 1-8 alkoxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched.
- the C 1-8 alkoxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 1-8 alkoxy group substituted by the halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a trifluoromethoxy group, a trichloromethoxy group, a difluoromethoxy group, and a dichloromethoxy group. 2,2,2-trifluoroethoxy group, 2,2,2-trichloroethoxy group, 1,1,2,2-tetrafluoroethoxy group, pentafluoroethoxy group, and pentachloroethoxy group.
- the C 1-8 alkylthio group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched.
- a methylthio group, an ethylthio group, an n-propylthio group, i -Propylthio group, n-butylthio group, i-butylthio group, s-butylthio group, t-butylthio group, n-pentylthio group, (2- or 3-methyl) butylthio group, 2,3-dimethylpropylthio group, n -Hexylthio group, (2,3- or 4-methyl) pentylthio group, (2,3,-, 2,4- or 3,4-dimethyl) butylthio group, 2,3,4-trimethylpropylthio group, n -Heptylthio group and n-octylthio group are exemplified, and preferably
- the C 1-8 alkylthio group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 1-8 alkylthio group substituted by a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a trifluoromethylthio group, a trichloromethylthio group, a difluoromethylthio group, a dichloromethylthio group.
- trifluoroethylthio group trifluoroethylthio group, trichloroethylthio group, tetrafluoroethylthio group, tetrachloroethylthio group, pentafluoroethylthio group, pentachloroethylthio group, heptafluoro-n-propylthio group, and heptafluoro-i-propylthio group
- trifluoromethylthio group trichloromethylthio group, difluoromethylthio group, dichloromethylthio group, trifluoroethylthio group, trichloroethylthio group, tetrafluoroethylthio group, tetrachloroethylthio group.
- the C 2-4 alkenyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched, for example, a vinyloxy group, (1- or 2-) propenyl Examples thereof include an oxy group, a (1-, 2- or 3-) butenyloxy group, a 1-methylvinyloxy group, a 1-methyl-1-propenyloxy group, and a 2-methyl-1-propenyloxy group.
- This C 2-4 alkenyloxy group is preferably a straight chain C 2-4 alkenyloxy group such as a vinyloxy group, a (1- or 2-) propenyloxy group, and (1-, 2- or 3- ) Butenyloxy group.
- the C 2-4 alkenyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 2-4 alkenyloxy group substituted with a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a 2-fluorovinyloxy group, a 2-chlorovinyloxy group, Examples include 2,2-difluorovinyloxy group, 2,2-dichlorovinyloxy group, and 3,3-dichloro (1- or 2-) propenyloxy group.
- the C 2-4 alkenyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- Examples of the C 2-4 alkenyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 and substituted with a C 1-4 alkoxy group optionally substituted with a halogen atom include 2 A trifluoromethoxyvinyloxy group.
- the C 2-4 alkenylthio group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched, for example, vinylthio group, (1- or 2-) propenyl Examples include a thio group, a (1-, 2- or 3-) butenylthio group, a 1-methylvinylthio group, a 1-methyl-1-propenylthio group, and a 2-methyl-1-propenylthio group.
- This C 2-4 alkenylthio group is preferably a straight chain C 2-4 alkenylthio group such as a vinylthio group, a (1- or 2-) propenylthio group, and (1-, 2- or 3- ) Butenylthio group.
- the C 2-4 alkenylthio group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 2-4 alkenylthio group substituted by a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a 2-fluorovinylthio group, a 2-chlorovinylthio group, Examples include 2,2-difluorovinylthio group and 2,2-dichlorovinylthio group.
- the C 2-4 alkenylthio group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- Examples of the C 2-4 alkenylthio group substituted by a C 1-4 alkoxy group optionally substituted by a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include 2 A trifluoromethoxyvinylthio group.
- the C 2-4 alkynyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be linear or branched, for example, an ethynyloxy group, (1- or 2-) Examples thereof include a propynyloxy group, a (1-, 2- or 3-) butynyloxy group, a 1-methylnitinyloxy group, a 1-methyl-1-propynyloxy group, and a 2-methyl-1-propynyloxy group.
- This C 2-4 alkynyloxy group is preferably a straight chain C 2-4 alkynyloxy group, for example, an ethynyloxy group, a (1- or 2-) propynyloxy group, and (1-, 2- or 3 -) A butynyloxy group is mentioned.
- the C 2-4 alkynyloxy group represented by R 6 , R 7 , R 8 , R 9 and R 10 may be substituted with a halogen atom.
- Examples of the C 2-4 alkynyloxy group substituted by a halogen atom represented by R 6 , R 7 , R 8 , R 9 and R 10 include a fluoroethynyloxy group, a chloroethynyloxy group, and 3-chloro (1- or 2-) propynyloxy group may be mentioned.
- n-O— (where n represents 1 or 2) includes, for example, —O— (CF 2 ) 2 —O—, —O— (CH 2 ) 2 —O—, —O—CH 2 CF 2 —. O—, —O—CHFCF 2 —O— and the like are mentioned, and preferably —O— (CF 2 ) 2 —O—.
- R 6 , R 7 , R 8 , R 9 and R 10 are independently of each other a hydrogen atom, chlorine atom, bromine atom, fluorine atom, methyl group, ethyl group, methoxy group.
- An ethoxy group, a trifluoromethyl group, a pentafluoroethyl group, a trifluoromethoxy group, or a 1,1,2,2-tetrafluoroethoxy group, or R 7 and R 8 together represent —O— ( CF 2 ) 2 —O—.
- any one of R 6 , R 7 , R 8 , R 9 and R 10 is a trifluoromethyl group, a methoxy group, a trifluoromethoxy group, or 1,1,2,2 -Represents a tetrafluoroethoxy group, and the remaining four represent a hydrogen atom.
- R 7 and R 8 together represent —O— (CF 2 ) 2 —O—.
- the C 1-8 alkyl group represented by R 11 , R 12 , and R 13 may be linear or branched, for example, methyl group, ethyl group, propyl group, i-propyl group, n-butyl Group, i-butyl group, s-butyl group, t-butyl group, n-pentyl group, (2- or 3-methyl) butyl group, 2,3-dimethylpropyl group, n-hexyl group, (2,3 Or 4-methyl) pentyl group, (2,3-, 2,4- or 3,4-dimethyl) butyl group, 2,3,4-trimethylpropyl group, n-heptyl group, and n-octyl group. It is done.
- the C 1-8 alkyl group represented by R 11 , R 12 , and R 13 may be substituted with a halogen atom.
- Examples of the C 1-8 alkyl group substituted by a halogen atom represented by R 11 , R 12 and R 13 include a chloromethyl group, a trichloromethyl group, a trifluoromethyl group, (1- or 2-) Examples include chloroethyl group, 2,2,2-trifluoroethyl group, 1,1,2,2-tetrafluoroethyl group, and pentafluoroethyl group.
- the C 1-8 alkyl group represented by R 11 , R 12 and R 13 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- Examples of the C 1-8 alkyl group represented by R 11 , R 12 , and R 13 and substituted with a C 1-4 alkoxy group optionally substituted with a halogen atom include a 2-trifluoromethoxyethyl group Is mentioned.
- C 3-6 cyclic alkyl group which may be substituted with a halogen atom represented by R 11 , R 12 and R 13 include a cyclopropylmethyl group, a cyclopropylethyl group, a cyclopropylpropyl group, -Methylcyclopropylmethyl group, 2- (1-methylcyclopropyl) ethyl group, 2,2-dimethylcyclopropylmethyl group, 2,2-dichlorocyclopropylmethyl group, 2- (2,2-dichlorocyclopropyl) Ethyl group, 3- (2,2-dichlorocyclopropyl) propyl group, 2,2-difluorocyclopropylmethyl group, 2- (2,2-difluorocyclopropyl) ethyl group, 3- (2,2-difluorocyclo) A propyl) propyl group, and a cyclohexyl group.
- the C 2-4 alkenyl group represented by R 11 , R 12 , and R 13 may be linear or branched.
- This C 2-4 alkenyl group is preferably a straight chain C 2-4 alkenyl group such as a vinyl group, a (1- or 2-) propenyl group, and a (1-, 2- or 3-) butenyl group. Is mentioned.
- the C 2-4 alkenyl group represented by R 11 , R 12 , and R 13 may be substituted with a halogen atom.
- Examples of the C 2-4 alkenyl group substituted with a halogen atom represented by R 11 , R 12 , and R 13 include a 2-fluorovinyl group, a 2-chlorovinyl group, a 2,2-difluorovinyl group, And 2,2-dichlorovinyl group.
- the C 2-4 alkenyl group represented by R 11 , R 12 and R 13 may be substituted with a C 1-4 alkoxy group which may be substituted with a halogen atom.
- Examples of the C 2-4 alkenyl group represented by R 11 , R 12 , and R 13 and substituted by a C 1-4 alkoxy group optionally substituted by a halogen atom include a 2-trifluoromethoxyvinyl group. Is mentioned.
- R 11 is optionally C 1-4 alkyl group optionally substituted by a halogen atom or OR 12 (wherein R 12 is optionally substituted by halogen atom C 1, -4 represents an alkyl group).
- R 11 represents OR 12 (where R 12 represents a C 1-4 alkyl group).
- the C 1-4 alkyl group in these embodiments is preferably a straight chain C 1-4 alkyl group, more preferably a methyl group.
- R 1 to R 11 , R 1 , R 2 and R 3 are independently of one another hydrogen, chlorine, bromine, fluorine, methyl, ethyl, Represents a methoxy group, an ethoxy group, or a trifluoromethyl group, provided that R 1 , R 2, and R 3 do not simultaneously represent a hydrogen atom, and R 4 and R 5 independently of each other represent a hydrogen atom or a halogen atom Represents a C 1-4 alkyl group which may be substituted by an atom, provided that R 4 and R 5 do not represent a hydrogen atom at the same time, and R 6 , R 7 , R 8 , R 9 and R 10 are Independently, hydrogen atom, chlorine atom, bromine atom, fluorine atom, methyl group, ethyl group, methoxy group, ethoxy group, trifluoromethyl group, pentafluoroethyl group, trifluo
- any one of R 1 , R 2 and R 3 represents a methyl group, a trifluoromethyl group or a methoxy group, the remaining two represent a hydrogen atom
- R 4 and R 5 represents a C 1-4 alkyl group which may be substituted with a halogen atom independently of each other
- any one of R 6 , R 7 , R 8 , R 9 and R 10 is a trifluoromethyl group
- R 7 and R 8 together represent —O— ( CF 2 ) 2 —O—
- R 11 represents OR 12 (where R 12 represents a C 1-4 alkyl group).
- any one of R 1 and R 2 represents a methyl group, a trifluoromethyl group, a methoxy group, the rest represents a hydrogen atom, R 3 is a hydrogen atom, and R 4 Represents a methyl group, an ethyl group, an n-propyl group, and a butyl group, R 5 represents a methyl group, an ethyl group, a propyl group, and a butyl group, and R 6 , R 7 , R 8 , R 9, and R 10 Any one of them represents a trifluoromethyl group, a methoxy group, a trifluoromethoxy group, or a 1,1,2,2-tetrafluoroethoxy group, and the remaining four represent a hydrogen atom, or R 7 , R 8 together represents —O— (CF 2 ) 2 —O—, R 11 represents OR 12 (where R 12 represents a C 1-4 alkyl group).
- a quinolone derivative represented by the general formula (2) and a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4) are present in the presence of a phase transfer catalyst and a base.
- a 4-carbonyloxyquinoline derivative represented by the general formula (1) useful as an agricultural or horticultural insecticide or an agricultural or horticultural fungicide can be obtained.
- the present invention will be described below.
- a quinolone derivative represented by the general formula (2) is reacted with a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4).
- the 4-carbonyloxyquinoline derivative represented by 1) is used.
- halogen compound represented by the general formula (3) examples include acetic acid halide, propionic acid halide, butanoic acid halide, cyclopropylcarboxylic acid halide, cyclopentylcarboxylic acid halide, cyclohexylcarboxylic acid halide, n-hexanoic acid halide, n -Octanoic acid halide, n-nonanoic acid halide, 2,2-dimethylpropanoic acid halide, acrylic acid halide, methacrylic acid halide, crotonic acid halide, isocrotonic acid halide, methyl halide formate, halogenated formate, isopropyl halide formate , Halogenated butyl formate, halogenated formate, and the like.
- chloride (chloride) and bromide (bromide) are preferable, and chloride
- acid anhydride represented by the general formula (4) examples include acetic anhydride, chloroacetic acid anhydride, trifluoroacetic acid anhydride, and cyclohexanecarboxylic acid anhydride. More preferred is acetic anhydride.
- phase transfer catalyst examples include quaternary ammonium salts such as tetraethylammonium chloride, tetraethylammonium bromide, tetrabutylammonium hydroxide, tetrabutylammonium bromide, benzyltributylammonium chloride, and methyltrioctylammonium chloride, and chloride.
- phase transfer catalyst to be used should be appropriately selected as appropriate depending on the combination with the base used at the same time described later.
- a metal carbonate, metal hydroxide, metal alkoxide, or metal hydride is used as the base, a quaternary ammonium salt is preferably used as the phase transfer catalyst, and tetrabutylammonium bromide is more preferable.
- the amount of the phase transfer catalyst used is not particularly limited, but is preferably 0.01 to 0.1 times mol, more preferably 0.03 to 0.06 times mol, with respect to the quinolone derivative.
- the production method of the present invention is performed in the presence of a base.
- the base used include inorganic bases such as alkali metal or alkaline earth metal carbonates or alkali metal or alkaline earth metal hydroxides, alkali metal or alkaline earth metal alkoxides, alkali metals or Alkaline earth metal hydrides include, preferably potassium carbonate, sodium carbonate, calcium carbonate, sodium bicarbonate, sodium hydroxide, sodium methoxide, sodium ethoxide, sodium-t-butoxide, or hydrogenated Sodium is mentioned.
- Inorganic bases such as alkali metal or alkaline earth metal carbonates or their hydroxides are advantageous in industrial production because they are low in danger and easy to handle, and are readily available and inexpensive. A good base. From this viewpoint, the base used is preferably sodium carbonate, potassium carbonate, sodium hydroxide, or potassium hydroxide, and particularly preferably sodium hydroxide.
- the base may be subjected to the reaction in the production method of the present invention in any state as a solid or a solution in an appropriate solvent. In the case of subjecting to a reaction as a solid, it is preferable to pulverize the base to be used into fine particles. When it is used for the reaction as a solution, it is preferably used after being dissolved in a soluble solvent inert to the base.
- the base solution is preferably prepared as a high concentration solution and subjected to the reaction.
- the base used preferably has a concentration of 8 to 14 N, more preferably a 30 to 70% by weight solution, still more preferably a 40 to 60% by weight solution.
- Particularly preferable bases include 8-14 N sodium hydroxide or potassium hydroxide aqueous solution, or sodium carbonate or potassium carbonate aqueous solution.
- the amount of the base used is preferably 0.1 to 5.0 times mol, more preferably 0.5 to 3.0 times mol for the quinolone derivative.
- the production method of the present invention can be typically carried out in the presence of a solvent.
- the solvent used is not particularly limited as long as it does not inhibit the reaction. These solvents may be used alone or in combination as a mixed solvent system, and a mixed solvent system is more preferable. As a mixed solvent system, it is preferable to use a mixture of water and an organic solvent.
- Examples of the solvent used in the production method of the present invention include water, benzene, toluene, xylene, mesitylene and other aromatic hydrocarbons, chlorobenzene, dichlorobenzene and other halogenated aromatic hydrocarbons, methylene chloride, chloroform, Halogenated aliphatic hydrocarbons such as dichloroethane, aliphatic hydrocarbons such as peptane, hexane, heptane, 2-methylbutane, 2-methylpentane, 2-methylhexane, cyclopentane, cyclohexane, cycloheptane, dimethylformamide, dimethyl Examples thereof include amides such as acetamide and N-methylpyrrolidone, ethers such as diisopropyl ether, and ketones such as 2-butanone.
- aromatic hydrocarbons, the halogenated aromatic hydrocarbons, the halogenated aliphatic hydrocarbons, the aliphatic hydrocarbons, the amides, the ethers, the quinolone derivative, and the halogen compound or It functions as a reaction solvent for dissolving the acid anhydride.
- aromatic hydrocarbons and halogenated aliphatic hydrocarbons are industrially advantageous solvents because they are readily available and inexpensive, and can be distilled off relatively easily.
- Preferred for use as the primary reaction solvent Specifically, toluene, xylene, and methylene chloride are particularly preferable.
- a more preferable solvent system is a mixed solvent system in which a small amount of the amide is added as a cosolvent to the aromatic hydrocarbon, aliphatic hydrocarbon, or halogenated aliphatic hydrocarbon. It is possible to increase solubility and reduce the amount of solvent used. Particularly preferred is a mixed solvent system of the aromatic hydrocarbons and the amides or a mixed solvent system of the halogenated aliphatic hydrocarbons and the amides. In the mixed solvent system, the mixing ratio is a mixed solvent system in which 3 to 20 parts by mass of the aromatic hydrocarbon or the halogenated aliphatic hydrocarbon are mixed with 1 part by mass of the amide. Is preferred.
- the amount of the solvent used is preferably 2 to 50 times by mass, more preferably 3 to 30 times by mass with respect to the quinolone derivative.
- water acts as a solvent for dissolving the base by adding it to the solvent system.
- Water may be added separately, but may be added as a basic aqueous solution. Water may be used in such an amount that the base to be added can be dissolved, and it is added in an amount of 0.01 to 0.1 times by mass with respect to the quinolone derivative dissolving solvent.
- a particularly preferred solvent system is an aromatic hydrocarbons-amides-water solvent system.
- Another embodiment is a solvent system of halogenated aliphatic hydrocarbons-amides-water.
- the quinolone derivative and the halogen compound are preferably brought into contact with each other in the liquid phase in the presence of a phase transfer catalyst and a base.
- a phase transfer catalyst and a base for example, in an inert gas atmosphere, the quinolone derivative, the phase transfer catalyst, The condensation reaction is carried out under normal pressure, increased pressure, or reduced pressure by a method in which a base, a halogen compound, and a solvent are mixed and stirred.
- the reaction temperature at that time is preferably ⁇ 50 to 100 ° C., more preferably ⁇ 10 to 50 ° C.
- the quinolone derivative may be used in the form of a salt with the base.
- the 4-carbonyloxyquinoline derivative which is the target product according to the present invention, can be isolated by a simple general post-treatment operation such as extraction or precipitation after completion of the reaction.
- the production method of the present invention uses aromatic hydrocarbons and halogenated aliphatic hydrocarbons as solvents as the main reaction solvent, specifically toluene, xylene, and methylene chloride, and is intended to aid dissolution. It is preferable to employ a mixed solvent system in which a small amount of an amide solvent, specifically, dimethylformamide, dimethylacetamide, and N-methylpyrrolidone are mixed as a cosolvent.
- the 4-carbonyloxyquinoline derivative which is the target product
- the target product can be precipitated and isolated by adding a small amount of a solvent in which the target product is insoluble or hardly soluble.
- the solvent added for precipitating the target product is not particularly limited, but water is preferable. Since the production method of the present invention can use a solvent that can be easily distilled off as a main reaction solvent, it is industrial in that the operation of isolating the target product is simple and the volume of the product precipitation tank can be reduced. This is an advantageous method.
- the 4-carbonyloxyquinoline derivative produced and isolated by the production method of the present invention is a product obtained as a high yield and high purity isolated product by collecting the precipitated solid by a filtration method. If necessary, it may be used as an agrochemical by separation and purification by recrystallization.
- a process for producing a 4-carbonyloxyquinoline derivative of the general formula (1) in the presence of a quaternary ammonium salt and an alkali metal or alkaline earth metal hydroxide comprising reacting a quinolone derivative represented by (2) with a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4) is exemplified.
- a process for producing a 4-carbonyloxyquinoline derivative of the general formula (1) in the presence of tetrabutylammonium bromide and an alkali metal or alkaline earth metal hydroxide in the presence of tetrabutylammonium bromide and an alkali metal or alkaline earth metal hydroxide.
- a quinolone derivative represented by the general formula (2) and a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4) is provided.
- a process for producing a 4-carbonyloxyquinoline derivative of the general formula (1) which is represented by the general formula (2) in the presence of a quaternary ammonium salt and sodium hydroxide.
- a production method comprising reacting a quinolone derivative with a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4) may be mentioned.
- a process for producing a 4-carbonyloxyquinoline derivative of the general formula (1) which is represented by the general formula (2) in the presence of tetrabutylammonium bromide and sodium hydroxide.
- a production method comprising reacting a quinolone derivative with a halogen compound represented by the general formula (3) or an acid anhydride represented by the general formula (4).
- Example 1 Synthesis of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4-yl methyl carbonate 3000 ml capacity equipped with stirrer, thermometer, reflux condenser In a glass container of 810 ml of toluene, 90 ml of dimethylacetamide, 113.2 g of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4 (1H) -one and tetrabutyl bromide 4.8 g of ammonium was added and stirred at room temperature.
- Example 2 Synthesis of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4-yl methyl carbonate 3000 ml capacity equipped with stirrer, thermometer, reflux condenser In a glass container, methylene chloride 1000 ml, dimethylacetamide 160 ml, 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4 (1H) -one 113.2 g and tetrabromide 4.8 g of butylammonium was added and stirred at room temperature.
- Comparative Example 1 Synthesis of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4-yl methyl carbonate A volume of 2000 ml equipped with a stirrer, thermometer and reflux condenser Into a glass container, 405 ml of toluene, 45 ml of dimethylacetamide, and 56.6 g of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4 (1H) -one were added and stirred at room temperature. did.
- Comparative Example 2 Synthesis of 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4-yl methyl carbonate A capacity of 2000 ml equipped with a stirrer, thermometer and reflux condenser Into a glass container, 15.1 g of sodium-t-butoxide, 45 ml of dimethylacetamide, 405 ml of toluene and 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinoline-4 (1H)- On 56.6 g was added and stirred at 30-35 ° C. for 1 hour.
- Example 2 WO 2010/007964 pamphlet (Patent Document 4),
- Example 8 2-ethyl-3,7-dimethyl-6- (4- (trifluoromethoxy) phenoxy) quinolin-4-yl methyl
- a nitrogen flask 2,000 ml of dimethylacetamide, 2-ethyl-3,7-dimethyl-6- (4-) were added to a glass flask having a capacity of 2000 ml equipped with a carbonate stirring apparatus, thermometer, reflux condenser, and calcium chloride tube.
- 98 g of (trifluoromethoxy) phenoxy) quinolin-4 (1H) -one was charged and cooled to 15 ° C.
- an inexpensive and easy-to-handle base such as sodium hydroxide can be used by using a phase transfer catalyst. Further, in this reaction, even when an excess base equivalent is provided, the target product is hardly decomposed, and this is an advantageous production method in that strict base charge equivalent management is not required.
- a reaction solvent such as toluene and methylene chloride which can be easily distilled off can be applied. That is, after completion of the reaction, after the post-treatment by simple aqueous washing, the solvent is distilled off, so that the crystallization of the target product can be operated in a small volume crystallization tank, and the efficiency in the isolation and purification operation is remarkable. Was recognized. Furthermore, since a small amount of dimethylacetamide is used, it can be said that this is an industrially advantageous production method because the addition to wastewater is reduced.
- the method for producing a 4-carbonyloxyquinoline derivative according to the present invention is inexpensive and easy to handle by using a phase transfer catalyst in the reaction of a quinolone derivative with a halogen compound or an acid anhydride. It is possible to use an easy base, which makes it possible to apply a reaction solvent that does not require strict base charge equivalence control and that can be easily distilled off, and further reduces the burden on wastewater. It was proved to be a high-yield production method.
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Abstract
Description
本発明は、農薬として有用な4-カルボニルオキシキノリン誘導体の製造方法に関するものである。
4-カルボニルオキシキノリン誘導体は、国際公開第2006/013896号パンフレット(特許文献1)、特開2008-110953号公報(特許文献2)、および国際公開第2007/088978号パンフレット(特許文献3)において農園芸用殺虫剤として、または農園芸用殺菌剤として有用な化合物であることが開示されている。これらの4-カルボニルオキシキノリン誘導体は、鱗翅目、半翅目、鞘翅目、ダニ目、膜翅目、直翅目、双翅目、アザミウマ目、および植物寄生性線虫に対して高い殺虫活性を示す化合物である。さらに、当該4-カルボニルオキシキノリン誘導体は農園芸用殺菌剤として、様々な植物病原真菌に対して効果を示し、例えば、キュウリうどん粉病菌、コムギ赤さび病菌、オオムギうどん粉病菌、トマト輪紋病菌、リンゴ黒星病菌、モモ灰星病菌、およびイチゴ炭疸病菌に対して殺菌効果を示す化合物として知られている。また当該4-カルボニルオキシキノリン誘導体の製造方法が、国際公開第2010/007964号パンフレット(特許文献4)に開示されている。
R1、R2およびR3は互いに独立して、水素原子、ハロゲン原子、ハロゲン原子により置換されていてもよいC1-4アルキル基、またはハロゲン原子により置換されていてもよいC1-4アルコキシ基を表し、ただし、R1、R2およびR3は同時に水素原子を表すことはなく、
R4およびR5は互いに独立して、水素原子、またはハロゲン原子により置換されていてもよいC1-4アルキル基を表し、ただし、R4およびR5が同時に水素原子を表すことはなく、あるいはR4とR5は一緒になって-(CH2)m-(ここで、mは3または4を表す)を表し、
R6、R7、R8、R9およびR10は互いに独立して、水素原子、ハロゲン原子、ハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC1-8アルコキシ基、ハロゲン原子により置換されていてもよいC1-8アルキルチオ基、ハロゲン原子により置換されていてもよいC2-4アルケニルオキシ基、ハロゲン原子により置換されていてもよいC2-4アルケニルチオ基、またはハロゲン原子により置換されていてもよいC2-4アルキニルオキシ基を表し、
あるいはR6、R7、R8、R9およびR10のいずれかの隣り合う二つの置換基が一緒になって1以上のハロゲン原子により置換されていてもよい-O-(CH2)n-O-(nは1または2を表す)を表し、
R11はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、ハロゲン原子により置換されていてもよいC2-4アルケニル基、OR12(ここで、R12はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、またはハロゲン原子により置換されていてもよいC2-4アルケニル基を表す)、SR13(ここで、R13はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、またはハロゲン原子により置換されていてもよいC2-4アルケニル基を表す)を表す。〕
の製造方法であって、
相間移動触媒および塩基の存在下、
一般式(2):
で示されるキノロン誘導体と、
一般式(3):
で示されるハロゲン化合物または一般式(4):
で示される酸無水物とを反応させることを含んでなる製造方法が提供される。
本明細書において「ハロゲン原子」とは、フッ素、塩素、臭素、またはヨウ素を意味し、好ましくはフッ素、塩素または臭素であり、より好ましくは塩素、フッ素である。
本発明の製造方法により生成し、単離された4-カルボニルオキシキノリン誘導体は、濾過法により析出固体を回収することにより、高収率で高純度な単離生成物として得られる物である。必要に応じて、再結晶による方法によって分離・精製することにより、農薬として使用しても良い。
撹拌装置、温度計、還流冷却器を備えた容量3000mlのガラス製容器にトルエン810ml、ジメチルアセトアミド90ml、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン 113.2gおよび臭化テトラブチルアンモニウム4.8gを加え室温下撹拌した。48%水酸化ナトリウム水溶液50gを30~35℃にて滴下し、同温度で1時間撹拌した。10~15℃に冷却後クロロ蟻酸メチル34gを滴下し、同温度で1時間反応した。反応液中に水を加え、洗浄後、トルエンを溜去し、析出した固体を吸引濾過器にて濾過した。固体を減圧乾燥し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート 128g(収率98%)を得た。1H-NMRの測定結果により、得られた化合物は、国際公開第2006/013896号パンフレット(特許文献1)に記載されているNo.120の化合物であることを確認した。
撹拌装置、温度計、還流冷却器を備えた容量3000mlのガラス製容器に塩化メチレン1000ml、ジメチルアセトアミド160ml、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン 113.2gおよび臭化テトラブチルアンモニウム4.8gを加え室温下撹拌した。48%水酸化ナトリウム水溶液50gを25~30℃にて滴下し、同温度で1時間撹拌した。10~15℃に冷却後クロロ蟻酸メチル34gを滴下し、同温度で1時間反応した。反応液中に水を加え、洗浄し、塩化メチレンを溜去後、メタノール990ml加え、加熱溶解する。水660mlを滴下し、結晶を析出させ、析出した固体を吸引濾過器にて濾過した。固体を減圧乾燥し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート 124.4g(収率95.2%)を得た。1H-NMRの測定結果により、得られた化合物は、国際公開第2006/013896号パンフレット(特許文献1)に記載されているNo.120の化合物であることを確認した。
攪拌装置、温度計、還流冷却器を備えた容量2000mlのガラス容器にトルエン405ml、ジメチルアセトアミド45ml、および2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン 56.6gを加え室温下撹拌した。48%水酸化ナトリウム水溶液25gを30~35℃にて滴下し、同温度で1時間撹拌した。10~15℃に冷却後、クロロ蟻酸メチル17gを滴下し、同温度で1時間反応した。反応液中に水を加え、析出した固体を濾別、乾燥し、未反応原料の2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン6.5g(収率11.5%)を回収した。濾液のトルエン層を水で洗浄後、濃縮し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート54.8g(収率83.9%)を得た。
攪拌装置、温度計、還流冷却器を備えた容量2000mlのガラス容器に、ナトリウム-t-ブトキシド15.1g、ジメチルアセトアミド45ml、トルエン405mlおよび2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン 56.6gを加え、30~35℃で1時間撹拌した。10~15℃に冷却後、クロロ蟻酸メチル15gを滴下し、同温度で1時間反応した。反応液中に水を加え、析出した固体を濾別、乾燥し、未反応原料の2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン6.4g(収率11.3%)を回収した。濾液のトルエン層を水で洗浄後、濃縮し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート55.6g(収率85.1%)を得た。
撹拌装置、温度計、還流冷却器を備えた容量1000mlのガラス製容器に窒素雰囲気下、ジメチルアセトアミド694ml、ナトリウム-t-ブトキシド35.2g、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン 131gを加え室温下撹拌した。クロロ蟻酸メチル34.4gを滴下し、室温にて1時間反応した。この反応混合物を5Lプラスチック容器中の水1735mlに注ぎ、室温にて2時間撹拌した。析出した固体を吸引濾過器にて濾過し、水で洗浄した。固体を減圧乾燥し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート 149.5g(収率98.8%)を得た。
撹拌装置、温度計、還流冷却器、塩化カルシウム管を備えた容量2000mlのガラス製フラスコに窒素雰囲気下、ジメチルアセトアミド980ml、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4(1H)-オン98gを仕込み、15℃に冷却した。55%水素化ナトリウム18.2gを加え、15~20℃で1時間撹拌した。クロロ蟻酸メチル32.1gを滴下し、室温にて1時間反応した。この反応混合物を10Lプラスチック容器中の氷水5Lに注ぎ、室温にて2時間撹拌した。析出した固体を吸引濾過器にて濾過し、n-ヘキサンと水で洗浄した。固体を減圧乾燥し、2-エチル-3,7-ジメチル-6-(4-(トリフルオロメトキシ)フェノキシ)キノリン-4-イル メチルカルボネート 103.3g(収率91.4%)を得た。
参考例1、2(国際公開第2010/007964号パンフレット(特許文献4)、実施例6および8)の4-カルボニルオキシキノリン誘導体を得る従来の製造法では、塩基としてナトリウム-t-ブトキシドまたは水素化ナトリウムが使用されている。これら塩基は反応性が高く、過剰量を加えた場合には目的生成物の分解をもたらす。このため塩基仕込み当量を厳密に管理する必要がある。また、これら塩基は吸湿分解性を有するため取扱いが困難であり、また高価な塩基であることから工業的製造方法として更なる改良が求められる。さらに、反応溶媒としてジメチルアセトアミドを大量に使用する必要があることから、生成物の単離操作において、ジメチルアセトアミド仕込量の2.5~5.1倍容量の水を添加する操作を必要とし、晶析槽の大容量化をもたらすと共に、析出固体の濾過回収操作において、操作効率の低下を招く恐れがある。さらに、濾液中のジメチルアセトアミド量が多く排水への負荷が大きいため、排水水溶液から高沸点溶媒であるジメチルアセトアミドの回収が必要となる場合がある。
Claims (4)
- 一般式(1)の4-カルボニルオキシキノリン誘導体:
R1、R2およびR3は互いに独立して、水素原子、ハロゲン原子、ハロゲン原子により置換されていてもよいC1-4アルキル基、またはハロゲン原子により置換されていてもよいC1-4アルコキシ基を表し、ただし、R1、R2およびR3は同時に水素原子を表すことはなく、
R4およびR5は互いに独立して、水素原子、またはハロゲン原子により置換されていてもよいC1-4アルキル基を表し、ただし、R4およびR5が同時に水素原子を表すことはなく、あるいはR4とR5は一緒になって-(CH2)m-(ここで、mは3または4を表す)を表し、
R6、R7、R8、R9およびR10は互いに独立して、水素原子、ハロゲン原子、ハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC1-8アルコキシ基、ハロゲン原子により置換されていてもよいC1-8アルキルチオ基、ハロゲン原子により置換されていてもよいC2-4アルケニルオキシ基、ハロゲン原子により置換されていてもよいC2-4アルケニルチオ基、またはハロゲン原子により置換されていてもよいC2-4アルキニルオキシ基を表し、
あるいはR6、R7、R8、R9およびR10のいずれかの隣り合う二つの置換基が一緒になって1以上のハロゲン原子により置換されていてもよい-O-(CH2)n-O-(nは1または2を表す)を表し、
R11はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、ハロゲン原子により置換されていてもよいC2-4アルケニル基、OR12(ここで、R12はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、またはハロゲン原子により置換されていてもよいC2-4アルケニル基を表す)、SR13(ここで、R13はハロゲン原子により置換されていてもよいC1-8アルキル基、ハロゲン原子により置換されていてもよいC3-6環状アルキル基、またはハロゲン原子により置換されていてもよいC2-4アルケニル基を表す)を表す。〕
の製造方法であって、
相間移動触媒および塩基の存在下、
一般式(2):
で示されるキノロン誘導体と、
一般式(3):
で示されるハロゲン化合物または一般式(4):
で示される酸無水物とを反応させることを含んでなる、製造方法。 - R1、R2およびR3のうちのいずれか一つがメチル基、トリフルオロメチル基、またはメトキシ基を表し、残りの二つは水素原子を表し、R4およびR5は互いに独立してハロゲン原子により置換されていてもよいC1-4アルキル基を表し、R6、R7、R8、R9およびR10のうちのいずれか一つがトリフルオロメチル基、メトキシ基、トリフルオロメトキシ基、または1,1,2,2-テトラフルオロエトキシ基を表し、残りの四つは水素原子を表し、あるいはR7と、R8とが一緒になって-O-(CF2)2-O-を表し、R11はOR12(ここでR12はC1-4アルキル基を表す)を表す、請求項1に記載の方法。
- 前記相間移動触媒が四級アンモニウム塩であり、前記塩基がアルカリ金属若しくはアルカリ土類金属の水酸化物、またはアルカリ金属若しくはアルカリ土類金属の炭酸化物である、請求項1または2に記載の方法。
- 前記相間移動触媒が臭化テトラブチルアンモニウムである、請求項1~3のいずれか一項に記載の方法。
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US13/885,783 US9126934B2 (en) | 2010-11-19 | 2011-11-16 | Process for producing 4-carbonyloxyquinoline derivatives |
JP2012544273A JP5961555B2 (ja) | 2010-11-19 | 2011-11-16 | 4−カルボニルオキシキノリン誘導体の製造方法 |
EP11841056.2A EP2641899A4 (en) | 2010-11-19 | 2011-11-16 | PREPARATION PROCESS FOR 4-CARBONYLOXYCHINOLINE DERIVATIVE |
KR1020137013960A KR101800923B1 (ko) | 2010-11-19 | 2011-11-16 | 4-카르보닐옥시퀴놀린 유도체의 제조방법 |
CN201180055571.XA CN103221393B (zh) | 2010-11-19 | 2011-11-16 | 制备4-羰氧基喹啉衍生物的方法 |
IL226097A IL226097A (en) | 2010-11-19 | 2013-05-01 | A process for producing a history of 4-carbonyloxyquinoline |
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JPS5210237A (en) * | 1975-07-07 | 1977-01-26 | Leo Ab | Acylation method of producing phenolic nndisubstituted carbamate ester and ionic solution for utilizing said method |
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WO2010007964A1 (ja) | 2008-07-15 | 2010-01-21 | 日本化薬株式会社 | 6-アリールオキシキノリン誘導体の製造方法およびその中間体 |
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TW201305111A (zh) | 2013-02-01 |
EP2641899A4 (en) | 2014-04-30 |
KR101800923B1 (ko) | 2017-11-23 |
US20130245271A1 (en) | 2013-09-19 |
KR20130114673A (ko) | 2013-10-17 |
IL226097A0 (en) | 2013-06-27 |
US9126934B2 (en) | 2015-09-08 |
CN103221393B (zh) | 2016-11-09 |
EP2641899A1 (en) | 2013-09-25 |
CN103221393A (zh) | 2013-07-24 |
IL226097A (en) | 2017-08-31 |
TWI547483B (zh) | 2016-09-01 |
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