WO2012062835A1 - Nouvelles compositions pharmaceutiques - Google Patents

Nouvelles compositions pharmaceutiques Download PDF

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Publication number
WO2012062835A1
WO2012062835A1 PCT/EP2011/069796 EP2011069796W WO2012062835A1 WO 2012062835 A1 WO2012062835 A1 WO 2012062835A1 EP 2011069796 W EP2011069796 W EP 2011069796W WO 2012062835 A1 WO2012062835 A1 WO 2012062835A1
Authority
WO
WIPO (PCT)
Prior art keywords
starch
capsule
pharmaceutical composition
adefovir dipivoxil
blend
Prior art date
Application number
PCT/EP2011/069796
Other languages
English (en)
Inventor
Samuel Bruce Balik
Karen Elodie Crews
Dustin Jack Melton
Ronald Allen Sanftleben
Allen Wayne Wood
Original Assignee
Glaxo Wellcome Manufacturing Pte Ltd
Glaxo Group Limited
Glaxosmithkline Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Manufacturing Pte Ltd, Glaxo Group Limited, Glaxosmithkline Inc. filed Critical Glaxo Wellcome Manufacturing Pte Ltd
Priority to CN2011800545845A priority Critical patent/CN103221037A/zh
Publication of WO2012062835A1 publication Critical patent/WO2012062835A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

La présente invention concerne de nouvelles compositions pharmaceutiques comprenant, en une seule forme pharmaceutique, de la lamivudine et de l'adéfovir dipixovil. L'invention concerne également l'utilisation de telles compositions pour le traitement de l'infection par le virus de l'hépatite B (VHB).
PCT/EP2011/069796 2010-11-12 2011-11-10 Nouvelles compositions pharmaceutiques WO2012062835A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011800545845A CN103221037A (zh) 2010-11-12 2011-11-10 新药物组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41282410P 2010-11-12 2010-11-12
US61/412,824 2010-11-12

Publications (1)

Publication Number Publication Date
WO2012062835A1 true WO2012062835A1 (fr) 2012-05-18

Family

ID=44999761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/069796 WO2012062835A1 (fr) 2010-11-12 2011-11-10 Nouvelles compositions pharmaceutiques

Country Status (2)

Country Link
CN (1) CN103221037A (fr)
WO (1) WO2012062835A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3372227A1 (fr) * 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Formulation de comprimé d'adéfovir dipivoxil

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020669A1 (fr) 1991-05-21 1992-11-26 Biochem Pharma Inc. Procedes de synthese diastereoselective de nucleosides
WO1995029174A1 (fr) 1994-04-23 1995-11-02 Glaxo Group Limited Procede de synthese diastereoselective d'analogues de nucleosides
WO1999004774A2 (fr) 1997-07-25 1999-02-04 Gilead Sciences, Inc. Compositions d'analogue de nucleotide
WO2000016755A2 (fr) * 1998-09-18 2000-03-30 Glaxo Group Limited Combinaisons antivirales
WO2000016779A1 (fr) * 1998-09-18 2000-03-30 Glaxo Group Limited Combinaisons antivirales contenant de la lamivudine et de l'abacavir
US20030229225A1 (en) * 2002-05-13 2003-12-11 Reddy K. Raja Novel phosphonic acid based prodrugs of PMEA and its analogues
CN101229178A (zh) * 2007-11-27 2008-07-30 北京润德康医药技术有限公司 一种含有阿德福韦酯的复方药用组合物及其制备方法、用途
WO2011082331A2 (fr) * 2009-12-31 2011-07-07 Zhou xiao-jian Compositions et méthodes pour traiter une infection provoquée par le virus de l'hépatite b

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020669A1 (fr) 1991-05-21 1992-11-26 Biochem Pharma Inc. Procedes de synthese diastereoselective de nucleosides
WO1995029174A1 (fr) 1994-04-23 1995-11-02 Glaxo Group Limited Procede de synthese diastereoselective d'analogues de nucleosides
WO1999004774A2 (fr) 1997-07-25 1999-02-04 Gilead Sciences, Inc. Compositions d'analogue de nucleotide
WO2000016755A2 (fr) * 1998-09-18 2000-03-30 Glaxo Group Limited Combinaisons antivirales
WO2000016779A1 (fr) * 1998-09-18 2000-03-30 Glaxo Group Limited Combinaisons antivirales contenant de la lamivudine et de l'abacavir
US20030229225A1 (en) * 2002-05-13 2003-12-11 Reddy K. Raja Novel phosphonic acid based prodrugs of PMEA and its analogues
CN101229178A (zh) * 2007-11-27 2008-07-30 北京润德康医药技术有限公司 一种含有阿德福韦酯的复方药用组合物及其制备方法、用途
WO2011082331A2 (fr) * 2009-12-31 2011-07-07 Zhou xiao-jian Compositions et méthodes pour traiter une infection provoquée par le virus de l'hépatite b

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Remington's Pharmaceutical Sciences", MACK PUBLISHING COMPANY
"The Handbook of Pharmaceutical Additives", GOWER PUBLISHING LIMITED
"The Handbook of Pharmaceutical Excipients", THE AMERICAN PHARMACEUTICAL ASSOCIATION AND THE PHARMACEUTICAL PRESS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3372227A1 (fr) * 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Formulation de comprimé d'adéfovir dipivoxil

Also Published As

Publication number Publication date
CN103221037A (zh) 2013-07-24

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