WO2012039642A8 - Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ её получения - Google Patents

Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ её получения Download PDF

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Publication number
WO2012039642A8
WO2012039642A8 PCT/RU2011/000322 RU2011000322W WO2012039642A8 WO 2012039642 A8 WO2012039642 A8 WO 2012039642A8 RU 2011000322 W RU2011000322 W RU 2011000322W WO 2012039642 A8 WO2012039642 A8 WO 2012039642A8
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
fast
antimicrobial
external administration
preparing
Prior art date
Application number
PCT/RU2011/000322
Other languages
English (en)
French (fr)
Other versions
WO2012039642A1 (ru
Inventor
Виктор Львович ЛИМОНОВ
Константин Валентинович ГАЙДУЛЬ
Александр Валерьевич ДУШКИН
Original Assignee
Limonov Viktor Lvovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES11827039.6T priority Critical patent/ES2531586T3/es
Priority to SI201130392T priority patent/SI2476420T1/sl
Application filed by Limonov Viktor Lvovich filed Critical Limonov Viktor Lvovich
Priority to US13/389,652 priority patent/US20130171198A1/en
Priority to AU2011304259A priority patent/AU2011304259C1/en
Priority to CN2011800044108A priority patent/CN102811724A/zh
Priority to EP11827039.6A priority patent/EP2476420B8/en
Priority to PL11827039T priority patent/PL2476420T3/pl
Priority to DK11827039.6T priority patent/DK2476420T3/en
Priority to BR112012023965A priority patent/BR112012023965A2/pt
Priority to JP2013529099A priority patent/JP2013537227A/ja
Priority to NZ598833A priority patent/NZ598833A/en
Priority to CA2780771A priority patent/CA2780771C/en
Priority to MEP-2015-30A priority patent/ME02057B/me
Priority to RS20150118A priority patent/RS53835B1/en
Priority to MX2012010536A priority patent/MX2012010536A/es
Priority to UAA201203808A priority patent/UA103117C2/ru
Publication of WO2012039642A1 publication Critical patent/WO2012039642A1/ru
Publication of WO2012039642A8 publication Critical patent/WO2012039642A8/ru
Priority to HRP20150112TT priority patent/HRP20150112T1/hr
Priority to SM201500048T priority patent/SMT201500048B/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармакологии, медицине, ветеринарии и к фармацевтической промышленности, в частности, к способу получения оригинальных композитных антимикробных и ранозаживляющих препаратов для наружного применения, которые обладают повышенной терапевтической эффективностью при лечении инфекций кожи и мягких тканей. Предложенная фармацевтическая композиция содержит в качестве действующего вещества антибиотик фосфомицин и высокодисперсный наноструктурированный диоксид кремния. Заявляемый способ получения фармацевтической композиции заключается в смешивании субстанции фосфомицина с высокодисперсным наноструктурированным диоксидом кремния отличающийся тем, что смесь вышеуказанных веществ в соотношениях (25-75 масс.%) : (75-25 масс.%), подвергают механической обработке путем ударно- истирающих воздействий до увеличения весовой доли мелкодисперсной фракции (≤5 мкм) не менее чем до 40%.
PCT/RU2011/000322 2010-09-20 2011-05-11 Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ её получения WO2012039642A1 (ru)

Priority Applications (18)

Application Number Priority Date Filing Date Title
NZ598833A NZ598833A (en) 2010-09-20 2011-05-11 Antimicrobial and wound-healing action pharmaceutical composition for external application process of producing the same
JP2013529099A JP2013537227A (ja) 2010-09-20 2011-05-11 抗菌性および創傷治癒作用を有する外用医薬組成物及びその製造方法
CA2780771A CA2780771C (en) 2010-09-20 2011-05-11 Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing sames
SI201130392T SI2476420T1 (sl) 2010-09-20 2011-05-11 Farmacevtski sestavek, ki ima antimikrobno in hitro-celilno aktivnost za zunanje dajanje, postopek za njegovo pripravo
CN2011800044108A CN102811724A (zh) 2010-09-20 2011-05-11 供外部施用的抗菌和外伤用药物组合物及其制造方法
EP11827039.6A EP2476420B8 (en) 2010-09-20 2011-05-11 Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same
PL11827039T PL2476420T3 (pl) 2010-09-20 2011-05-11 Kompozycja farmaceutyczna o działaniu przeciwbakteryjnym i szybko gojącym do podawania zewnętrznego, sposób jej wytwarzania
DK11827039.6T DK2476420T3 (en) 2010-09-20 2011-05-11 A pharmaceutical composition having antimicrobial activity and rapid healing for external application as well as process for their preparation
BR112012023965A BR112012023965A2 (pt) 2010-09-20 2011-05-11 composição farmacêutica de ação atimicrobiana e de cura de feridas para aplicação externa e processo de produção da mesma
ES11827039.6T ES2531586T3 (es) 2010-09-20 2011-05-11 Compuesto farmacéutico con actividad antimicrobiana y de curación rápida, para administración externa y procedimiento para su fabricación
AU2011304259A AU2011304259C1 (en) 2010-09-20 2011-05-11 Antimicrobial and wound-healing action pharmaceutical composition for external application process of producing the same
US13/389,652 US20130171198A1 (en) 2010-09-20 2011-05-11 Antimicrobial and vulnerary action pharmaceutical composition for external application and its production process
MEP-2015-30A ME02057B (me) 2010-09-20 2011-05-11 Farmaceutska kompozicija sa antimikrobnim djelovanjem i za ubrzano zacjeljivanje, za spoljašnju administraciju, procesi za njeno dobijanje
RS20150118A RS53835B1 (en) 2010-09-20 2011-05-11 PHARMACEUTICAL COMPOSITION WITH ANTIMICROBIC ACTION AND FOR ACCELERATED HEALING, FOR EXTERNAL ADMINISTRATION, PROCESSES FOR ITS ACQUISITION
MX2012010536A MX2012010536A (es) 2010-09-20 2011-05-11 Composicion farmaceutica con actividad antimicrobiana y cicatrizante de heridas para aplicacion externa y procedimiento de produccion de la misma.
UAA201203808A UA103117C2 (ru) 2010-09-20 2011-11-05 Фармацевтическая композиция антимикробного и ранозаживляющего действия для внешнего применения, способ ее получения
HRP20150112TT HRP20150112T1 (hr) 2010-09-20 2015-01-30 Farmaceutski sastav koji ima antimikrobnu i aktivnost brzog zarastanja za vanjsku primjenu, postupak za njegovu pripremu
SM201500048T SMT201500048B (it) 2010-09-20 2015-03-02 Composizione farmaceutica con attivita'antimicrobica e cicatrizzante per somministrazione esterna e procedimento per la preparazione della stessa

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EA201001506A EA021875B1 (ru) 2010-09-20 2010-09-20 Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ ее получения
EA201001506 2010-09-20

Publications (2)

Publication Number Publication Date
WO2012039642A1 WO2012039642A1 (ru) 2012-03-29
WO2012039642A8 true WO2012039642A8 (ru) 2012-09-07

Family

ID=45874028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2011/000322 WO2012039642A1 (ru) 2010-09-20 2011-05-11 Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ её получения

Country Status (22)

Country Link
US (1) US20130171198A1 (ru)
EP (1) EP2476420B8 (ru)
JP (1) JP2013537227A (ru)
CN (1) CN102811724A (ru)
AU (1) AU2011304259C1 (ru)
BR (1) BR112012023965A2 (ru)
CA (1) CA2780771C (ru)
CY (1) CY1116245T1 (ru)
DK (1) DK2476420T3 (ru)
EA (1) EA021875B1 (ru)
ES (1) ES2531586T3 (ru)
HR (1) HRP20150112T1 (ru)
ME (1) ME02057B (ru)
MX (1) MX2012010536A (ru)
NZ (1) NZ598833A (ru)
PL (1) PL2476420T3 (ru)
PT (1) PT2476420E (ru)
RS (1) RS53835B1 (ru)
SI (1) SI2476420T1 (ru)
SM (1) SMT201500048B (ru)
UA (1) UA103117C2 (ru)
WO (1) WO2012039642A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2476206C1 (ru) 2011-11-22 2013-02-27 Виктор Львович Лимонов Фармацевтическая композиция для приготовления инфузионных растворов антимикробных препаратов, способ ее получения (варианты)
WO2015067603A1 (en) * 2013-11-06 2015-05-14 Invenres Gmbh Pharmaceutical preparation and method of its production and use
JP2017509599A (ja) * 2014-02-05 2017-04-06 レポネックス・ファーマシューティカルズ・エーピーエス 皮膚潰瘍及び創傷の治癒を促進するための組成物
EP3171887A1 (en) 2014-07-24 2017-05-31 Reponex Pharmaceuticals APS Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3252859A (en) * 1962-10-24 1966-05-24 Masti Kure Company Inc Colloidal silica-oil composition and method of using same
IT1243180B (it) * 1990-07-31 1994-05-24 Nunzio Rapisarda Uso della fosfomicina e dei suoi sali come agente cicatrizzante topico
FR2687071B1 (fr) * 1992-02-10 1995-06-23 Exsymol Sa Vecteur pour principe(s) actif(s) therapeutique(s) ou cosmetique(s) a usage externe et composition therapeutique ou cosmetique comprenant un tel vecteur.
JPH09183720A (ja) * 1995-12-28 1997-07-15 Shiseido Co Ltd 医薬用組成物
UA32088C2 (en) * 1998-12-23 2004-07-15 Yurii Mykolaiovych Shevchenko Wound healing preparation and method for its manufacture
EA013864B1 (ru) * 2008-08-29 2010-08-30 Лимонова, Анастасия Викторовна Способ повышения антимикробной активности цефалоспориновых антибиотиков

Also Published As

Publication number Publication date
AU2011304259C1 (en) 2012-11-29
RS53835B1 (en) 2015-06-30
ES2531586T3 (es) 2015-03-17
JP2013537227A (ja) 2013-09-30
PT2476420E (pt) 2015-02-13
EP2476420A4 (en) 2013-04-03
BR112012023965A2 (pt) 2016-08-02
CA2780771C (en) 2015-12-08
DK2476420T3 (en) 2015-02-16
CN102811724A (zh) 2012-12-05
SI2476420T1 (sl) 2015-03-31
MX2012010536A (es) 2012-11-16
EP2476420B1 (en) 2014-11-26
NZ598833A (en) 2015-11-27
EA201001506A1 (ru) 2012-02-28
AU2011304259B8 (en) 2012-07-05
ME02057B (me) 2015-05-20
CA2780771A1 (en) 2012-03-29
EP2476420A1 (en) 2012-07-18
WO2012039642A1 (ru) 2012-03-29
UA103117C2 (ru) 2013-09-10
US20130171198A1 (en) 2013-07-04
SMT201500048B (it) 2015-05-05
HRP20150112T1 (hr) 2015-05-08
EP2476420B8 (en) 2015-02-18
PL2476420T3 (pl) 2015-06-30
CY1116245T1 (el) 2017-02-08
AU2011304259B2 (en) 2012-06-28
EA021875B1 (ru) 2015-09-30
AU2011304259A1 (en) 2012-04-19
AU2011304259A8 (en) 2012-07-05

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