HRP20150112T1 - Farmaceutski sastav koji ima antimikrobnu i aktivnost brzog zarastanja za vanjsku primjenu, postupak za njegovu pripremu - Google Patents
Farmaceutski sastav koji ima antimikrobnu i aktivnost brzog zarastanja za vanjsku primjenu, postupak za njegovu pripremu Download PDFInfo
- Publication number
- HRP20150112T1 HRP20150112T1 HRP20150112TT HRP20150112T HRP20150112T1 HR P20150112 T1 HRP20150112 T1 HR P20150112T1 HR P20150112T T HRP20150112T T HR P20150112TT HR P20150112 T HRP20150112 T HR P20150112T HR P20150112 T1 HRP20150112 T1 HR P20150112T1
- Authority
- HR
- Croatia
- Prior art keywords
- finely dispersed
- pharmaceutical composition
- fosfomycin
- weight
- antimicrobial
- Prior art date
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000000694 effects Effects 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 11
- YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 claims 5
- 229960000308 fosfomycin Drugs 0.000 claims 5
- 239000000377 silicon dioxide Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 238000005299 abrasion Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (4)
1. Antimikrobni farmaceutski sastav za rane za vanjsku primjenu koji sadrži antibiotik fosfomicin kao terapeutski agens, naznačen time što je pripravljen u obliku praška i sadrži fino raspršen nanostrukturirani silicijev dioksid u težinskom omjeru fosfomicin : fino raspršen nanostrukturirani silicijev dioksid od (25-75% težinski) : (75-25% težinski).
2. Sastav temeljem zahtjeva 1, naznačen time što je postotak čestica fino raspršenog nanostrukturiranog silicijevog dioksida veličine ≤ od 5 mikrona barem 40%.
3. Postupak za proizvodnju antimikrobnog farmaceutskog sastava za rane za vanjsku primjenu koji uključuje miješanje fosfomicina sa drugim komponentama, naznačen time što se fosfomicin u obliku praška miješa za praškastim fino raspršenim nanostrukturiranim silicijevim dioksidom u težinskom omjeru fosfomicin : fino raspršen nanostrukturirani silicijev dioksid od (25-75% težinski) : (75-25% težinski), a dobivena smjesa je podvrgnuta mehaničkoj obradi radnjama udaranja i abrazije.
4. Postupak temeljem zahtjeva 3, naznačen time što je smjesa podvrgnuta mehaničkoj obradi radnjama udaranja i abrazije tako da je postotak čestica fino raspršenog nanostrukturiranog silicijevog dioksida veličine ≤ od 5 mikrona barem 40%.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA201001506A EA021875B1 (ru) | 2010-09-20 | 2010-09-20 | Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ ее получения |
| EP11827039.6A EP2476420B8 (en) | 2010-09-20 | 2011-05-11 | Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same |
| PCT/RU2011/000322 WO2012039642A1 (ru) | 2010-09-20 | 2011-05-11 | Фармацевтическая композиция антимикробного и ранозаживляющего действия для наружного применения, способ её получения |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150112T1 true HRP20150112T1 (hr) | 2015-05-08 |
Family
ID=45874028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150112TT HRP20150112T1 (hr) | 2010-09-20 | 2015-01-30 | Farmaceutski sastav koji ima antimikrobnu i aktivnost brzog zarastanja za vanjsku primjenu, postupak za njegovu pripremu |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20130171198A1 (hr) |
| EP (1) | EP2476420B8 (hr) |
| JP (1) | JP2013537227A (hr) |
| CN (1) | CN102811724A (hr) |
| AU (1) | AU2011304259C1 (hr) |
| BR (1) | BR112012023965A2 (hr) |
| CA (1) | CA2780771C (hr) |
| CY (1) | CY1116245T1 (hr) |
| DK (1) | DK2476420T3 (hr) |
| EA (1) | EA021875B1 (hr) |
| ES (1) | ES2531586T3 (hr) |
| HR (1) | HRP20150112T1 (hr) |
| ME (1) | ME02057B (hr) |
| MX (1) | MX2012010536A (hr) |
| NZ (1) | NZ598833A (hr) |
| PL (1) | PL2476420T3 (hr) |
| PT (1) | PT2476420E (hr) |
| RS (1) | RS53835B1 (hr) |
| SI (1) | SI2476420T1 (hr) |
| SM (1) | SMT201500048B (hr) |
| UA (1) | UA103117C2 (hr) |
| WO (1) | WO2012039642A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2476206C1 (ru) | 2011-11-22 | 2013-02-27 | Виктор Львович Лимонов | Фармацевтическая композиция для приготовления инфузионных растворов антимикробных препаратов, способ ее получения (варианты) |
| JP2016535790A (ja) * | 2013-11-06 | 2016-11-17 | インヴェンレス・ゲーエムベーハー | 医薬製剤ならびにその製造および使用 |
| EP3104874B1 (en) * | 2014-02-05 | 2020-01-01 | Reponex Pharmaceuticals A/S | Compositions to promote the healing of skin ulcers and wounds |
| WO2016012608A1 (en) | 2014-07-24 | 2016-01-28 | Reponex Pharmaceuticals Aps | Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3252859A (en) * | 1962-10-24 | 1966-05-24 | Masti Kure Company Inc | Colloidal silica-oil composition and method of using same |
| IT1243180B (it) * | 1990-07-31 | 1994-05-24 | Nunzio Rapisarda | Uso della fosfomicina e dei suoi sali come agente cicatrizzante topico |
| FR2687071B1 (fr) * | 1992-02-10 | 1995-06-23 | Exsymol Sa | Vecteur pour principe(s) actif(s) therapeutique(s) ou cosmetique(s) a usage externe et composition therapeutique ou cosmetique comprenant un tel vecteur. |
| JPH09183720A (ja) * | 1995-12-28 | 1997-07-15 | Shiseido Co Ltd | 医薬用組成物 |
| UA32088C2 (en) * | 1998-12-23 | 2004-07-15 | Yurii Mykolaiovych Shevchenko | Wound healing preparation and method for its manufacture |
| EA013864B1 (ru) * | 2008-08-29 | 2010-08-30 | Лимонова, Анастасия Викторовна | Способ повышения антимикробной активности цефалоспориновых антибиотиков |
-
2010
- 2010-09-20 EA EA201001506A patent/EA021875B1/ru not_active IP Right Cessation
-
2011
- 2011-05-11 NZ NZ598833A patent/NZ598833A/en not_active IP Right Cessation
- 2011-05-11 AU AU2011304259A patent/AU2011304259C1/en not_active Ceased
- 2011-05-11 EP EP11827039.6A patent/EP2476420B8/en active Active
- 2011-05-11 PL PL11827039T patent/PL2476420T3/pl unknown
- 2011-05-11 JP JP2013529099A patent/JP2013537227A/ja not_active Withdrawn
- 2011-05-11 MX MX2012010536A patent/MX2012010536A/es active IP Right Grant
- 2011-05-11 DK DK11827039.6T patent/DK2476420T3/en active
- 2011-05-11 RS RS20150118A patent/RS53835B1/en unknown
- 2011-05-11 CN CN2011800044108A patent/CN102811724A/zh active Pending
- 2011-05-11 CA CA2780771A patent/CA2780771C/en not_active Expired - Fee Related
- 2011-05-11 SI SI201130392T patent/SI2476420T1/sl unknown
- 2011-05-11 ES ES11827039.6T patent/ES2531586T3/es active Active
- 2011-05-11 WO PCT/RU2011/000322 patent/WO2012039642A1/ru active Application Filing
- 2011-05-11 BR BR112012023965A patent/BR112012023965A2/pt not_active Application Discontinuation
- 2011-05-11 PT PT118270396T patent/PT2476420E/pt unknown
- 2011-05-11 US US13/389,652 patent/US20130171198A1/en not_active Abandoned
- 2011-05-11 ME MEP-2015-30A patent/ME02057B/me unknown
- 2011-11-05 UA UAA201203808A patent/UA103117C2/uk unknown
-
2015
- 2015-01-30 HR HRP20150112TT patent/HRP20150112T1/hr unknown
- 2015-02-25 CY CY20151100198T patent/CY1116245T1/el unknown
- 2015-03-02 SM SM201500048T patent/SMT201500048B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS53835B1 (en) | 2015-06-30 |
| CA2780771C (en) | 2015-12-08 |
| EP2476420A1 (en) | 2012-07-18 |
| WO2012039642A8 (ru) | 2012-09-07 |
| CN102811724A (zh) | 2012-12-05 |
| ES2531586T3 (es) | 2015-03-17 |
| DK2476420T3 (en) | 2015-02-16 |
| NZ598833A (en) | 2015-11-27 |
| SI2476420T1 (sl) | 2015-03-31 |
| WO2012039642A1 (ru) | 2012-03-29 |
| AU2011304259B8 (en) | 2012-07-05 |
| SMT201500048B (it) | 2015-05-05 |
| AU2011304259A1 (en) | 2012-04-19 |
| EP2476420B1 (en) | 2014-11-26 |
| AU2011304259C1 (en) | 2012-11-29 |
| BR112012023965A2 (pt) | 2016-08-02 |
| AU2011304259A8 (en) | 2012-07-05 |
| UA103117C2 (uk) | 2013-09-10 |
| MX2012010536A (es) | 2012-11-16 |
| JP2013537227A (ja) | 2013-09-30 |
| PT2476420E (pt) | 2015-02-13 |
| EP2476420B8 (en) | 2015-02-18 |
| PL2476420T3 (pl) | 2015-06-30 |
| EA201001506A1 (ru) | 2012-02-28 |
| AU2011304259B2 (en) | 2012-06-28 |
| ME02057B (me) | 2015-05-20 |
| EP2476420A4 (en) | 2013-04-03 |
| EA021875B1 (ru) | 2015-09-30 |
| US20130171198A1 (en) | 2013-07-04 |
| CA2780771A1 (en) | 2012-03-29 |
| CY1116245T1 (el) | 2017-02-08 |
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