WO2012032636A1 - Récipient de mélange de deux agents - Google Patents

Récipient de mélange de deux agents Download PDF

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Publication number
WO2012032636A1
WO2012032636A1 PCT/JP2010/065533 JP2010065533W WO2012032636A1 WO 2012032636 A1 WO2012032636 A1 WO 2012032636A1 JP 2010065533 W JP2010065533 W JP 2010065533W WO 2012032636 A1 WO2012032636 A1 WO 2012032636A1
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WO
WIPO (PCT)
Prior art keywords
container
middle container
chamber
agent
component mixing
Prior art date
Application number
PCT/JP2010/065533
Other languages
English (en)
Japanese (ja)
Inventor
洋 岸岡
深澤　眞
晃 見眞地
Original Assignee
Ｄｉｃプラスチック株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ｄｉｃプラスチック株式会社 filed Critical Ｄｉｃプラスチック株式会社
Priority to JP2011507727A priority Critical patent/JP4844703B1/ja
Priority to PCT/JP2010/065533 priority patent/WO2012032636A1/fr
Publication of WO2012032636A1 publication Critical patent/WO2012032636A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216—Rigid containers disposed one within the other
    • B65D81/3222—Rigid containers disposed one within the other with additional means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2031—Separating means having openings brought into alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed

Definitions

  • the present invention relates to a two-component mixing container capable of mixing two agents separately contained in a container.
  • a container for mixing two agents has been used.
  • a diagnostic agent used by mixing two agents for example, a diagnostic kit for an infectious disease group A streptococcus causing pharyngitis in children is sold.
  • the method of using this diagnostic kit is as follows. First, at the time of inspection, two types of reagent A liquid and B liquid are added to each extraction tube from each bottle, and gently mixed. Then, a sample is collected by rubbing the affected part such as the pharynx of the human body with a cotton swab, and the sample is then immersed in the mixed reagent (A + B) in the extraction tube.
  • the sample is extracted into the mixed reagent by squeezing the swab with the flexible tube. Then, the result is determined after a predetermined time has elapsed since the test strip was immersed in the sample extract in the extraction tube.
  • a reagent is altered when stored in advance and cannot be used for inspection. Therefore, it must be mixed at the time of inspection at the medical site.
  • a nurse or a laboratory technician When using the above diagnostic agent, a nurse or a laboratory technician usually performs an operation of mixing reagent A and reagent B at a medical site. However, for reasons such as busyness when many operations are performed, the A liquid and the B liquid may be mistaken, the mixing ratio of the A liquid and the B liquid may be mistaken, or the addition may be forgotten. In such a case, a correct diagnosis result may not be obtained, such as a false positive result in spite of being negative or a false negative result in spite of being positive. Such a case brought extra work, such as the need for re-examination.
  • an object of the present invention is to provide an easy-to-use two-component mixing container that can smoothly mix two components in a separated state.
  • the first aspect of the present invention is a two-component mixing container having a container body and a middle container that is detachably inserted from its opening,
  • the middle container has a second chamber for accommodating the second agent, and one or more side openings formed on the side surface thereof,
  • the container body is sealed by a bottom portion of the middle container, and communicates the first chamber with the second chamber when the middle container is retracted, and a first chamber containing the first agent, It is a two-agent mixing container characterized by having an agent movement location.
  • the two-component mixing container of the present invention preferably has the following characteristics.
  • the middle container is accommodated in the middle container housing portion of the container body, and the bottom portion of the middle container contacts the inside of the middle container housing portion to seal the first chamber in a liquid-tight manner. It is preferable to have an outer surface side close portion that stops.
  • the container main body has the second agent moving portion in the middle container housing portion, and the inner cross-sectional shape of the second agent moving portion orthogonal to the longitudinal direction of the container is It is preferable that it is larger than the outer cross-sectional shape of the outer surface side close contact portion of the container.
  • the container main body has one or more inner surface side intimate portions that are in close contact with the middle container, and the middle container is further in close contact with the container main body in addition to the outer surface side intimate portion. It is preferable to have one or more outer surface side close portions.
  • the middle container has a columnar portion including the side opening and the bottom, and the middle container housing portion of the container body is in close contact with the outer surface side of the bottom of the middle container. It is preferable that a taper portion with which the portion abuts is formed, and a gap is formed between the cylindrical portion and the tapered portion when the middle container is retracted.
  • the middle container has a columnar portion including the side opening and the bottom, and the outer surface close contact portion of the bottom is located on at least one of the side surface and the bottom surface of the bottom.
  • the middle container housing portion of the container body has a step portion that contacts the outer surface side close portion of the middle container. When the middle container is retracted, the middle portion and the step portion It is preferable that a gap is formed.
  • the middle container has a tapered portion including the side opening and the bottom, the side surface of the bottom is the outer side close contact portion, and the container main body is the middle container housing portion. It is preferable that at least a part of these tapered parts abut against each other, and a gap is formed between the tapered parts when the inner container is retracted.
  • the middle container has a columnar portion including the side opening and the bottom, has the outer surface side intimate portion on the side of the bottom, and the middle container of the container body.
  • the accommodating portion has a cylindrical portion that has a groove portion formed on an inner wall and contacts the outer surface side intimate portion of the middle container below the groove portion, and when the middle container is retracted, the middle portion It is preferable that a gap is formed between the cylindrical portion of the container and the groove portion of the cylindrical portion of the container body.
  • the middle container has a columnar part including the bottom part, the outer surface side intimate part is provided on a side surface of the bottom part, and the middle container accommodating part of the container body is a tapered part.
  • a columnar portion that is located below and contacts the outer surface side intimate portion of the middle container, and when the middle container is retracted, the columnar portion of the middle container and the container body It is preferable that a gap be formed between the tapered portion.
  • the middle container is attached to the container body by screwing.
  • a bottom portion of the second chamber of the middle container has an outflow guide portion.
  • the container main body has a substantially cylindrical shape in which the first cylindrical portion x, the second cylindrical portion y, and the third cylindrical portion z are continuous in this order, and the first cylindrical portion x Has the opening, the inner diameter is larger than the second cylinder part y, the second cylinder part y has an inner diameter larger than the third cylinder part z, and the third cylinder part z
  • the first chamber is preferably formed together with the bottom of the second chamber of the container.
  • the container body has one or more inner surface side intimate portions that are in intimate contact with the middle container, and one of the inner surface intimate portions is in the second cylindrical portion y, or in the second It is preferable to be formed adjacent to the cylindrical portion y.
  • the middle container has a substantially cylindrical shape in which the first cylindrical part X, the second cylindrical part Y, and the third cylindrical part Z are continuous in this order, and the first cylindrical part X
  • the insides of the second cylinder part Y and the third cylinder part Z are preferably the second chamber.
  • the middle container In the two-component mixing container, the middle container is retracted in a direction opposite to the bottom of the container main body, the outer surface side intimate part is positioned at the second agent moving position, and the second agent is It is preferable to move to the first agent contained in one chamber.
  • the middle container has a second agent inlet for introducing the second agent and a covering portion for preventing leakage of the second agent from the second agent inlet. Is preferred.
  • the two-component mixing container preferably further has a sealing lid for sealing the second chamber of the middle container.
  • the container body is formed from a soft synthetic resin and the middle container is formed from a hard synthetic resin.
  • the middle container can accommodate another middle container detachably from its opening.
  • the second agent in the second chamber flows smoothly from the second chamber to the first chamber of the container body through the side opening of the middle container, and the two agents are easily added. Can be mixed.
  • FIG. 9 is a side sectional view of the middle container in FIG. 8. It is a side view which shows an example of the outer container (container main body) of the two agent mixing container of this invention. It is a sectional side view of the outer container of FIG. It is a side view of the 2 agent mixing container which shows another example of this invention.
  • FIG. 14 is a side sectional view of the two-component mixing container shown in FIG. 13. It is the side view and top view of the container main body of the two component mixing container shown in FIG. It is the side view and top and bottom view of the middle container of a 2 agent mixing container shown in FIG.
  • FIG. 14 is a side sectional view of the two-component mixing container shown in FIG. 13 in a two-component separation state.
  • FIG. 14 is a side sectional view of the two-component mixing container shown in FIG. 13 that is in the middle of two-component mixing by loosening the middle container.
  • FIG. 13 It is a sectional side view of the 2 agent mixing container shown in FIG. 13 in the state which 2 agents mixed. It is a figure which shows an example of the outflow guide which can be formed in the bottom part of a middle container. It is a figure which shows an example of the outflow guide which can be formed in the bottom part of a middle container. It is a side view which shows an example of the 2 agent mixing container of this invention. It is a bottom view of the 2 agent mixing container of FIG. 23A.
  • FIG. 23B is a side view in which a sealing cap is attached to the two-component mixing container shown in FIG. 23A. It is sectional drawing of the sealing cap shown to FIG. 24A. It is side sectional drawing of the container main body of the 2 agent mixing container shown to FIG.
  • FIG. 33B is an enlarged cross-sectional view showing a close contact portion between the container main body and the middle container in FIG. 33A. It is a sectional side view of the two-component mixing container showing an example of the present invention.
  • FIG. 1 to 6 show an example of the two-component mixing container 1 of the present invention
  • FIGS. 7 to 9 show side views of the middle container 3 included in the aforementioned two-component mixing container
  • FIG. 10 shows the middle container.
  • 3 shows a side cross-sectional view
  • 11 and 12 show a side view and a sectional view of the container body 2 of the two-component mixing container described above.
  • the two-component mixing container 1 of the present invention has a container body 2 and a middle container 3 that is detachably inserted from the opening 2a.
  • the middle container 3 includes a second chamber Q that accommodates the second agent B, and one or more side openings 10 formed on the side surfaces thereof.
  • the container body 2 includes a first chamber P for storing the first agent A sealed by the bottom 3b of the middle container 3, and a first chamber P and a second chamber Q when the middle container 3 is retracted upward. And a second agent moving portion 13 (A) for communicating with each other.
  • the middle container 3 is housed in the middle container housing part 2h of the container body 2, and the bottom 3b of the middle container 3 contacts the inside of the middle container housing part 2h to seal the first chamber P in a liquid-tight manner.
  • the outer surface side close portion 3f is provided.
  • the container body 2 has a second agent moving portion 13 (A) where the second agent can move in the middle container housing portion 2h.
  • the inner cross-sectional shape at the second agent moving portion 13 (A) orthogonal to the longitudinal direction of the two-agent mixing container 1 is the outer surface side of the bottom 3b of the middle container 3 in order to enable the second agent B to move. It is larger than the outer cross-sectional shape at the close contact portion 3f.
  • the second agent moving portion 13 (A) causes the first chamber P and the second chamber Q to communicate with each other when the middle container 3 is retracted upward.
  • the upper end of the middle container 3 is sealed with a covering material 4 as shown in FIGS. 5 and 6 (see FIG. 4).
  • the side opening 10 and the bottom 3b are provided in a cylindrical portion, and the middle container housing part 2h of the container body 2 is tapered such that the outer surface side close part 3f of the bottom 3b of the middle container 3 contacts.
  • a portion (stepped portion) 5 is provided.
  • the middle container 3 is retracted upward, a gap is formed between the columnar portion and the tapered portion 5.
  • the columnar portion may be slightly tapered.
  • the outer surface side close contact portion 3 f of the bottom portion 3 b of the middle container 3 may abut on the upper end of the tapered portion (stepped portion) 5.
  • the container body 2 has one or more inner surface side close portions 2i that are in close contact with the middle container 3.
  • the middle container 3 is further in close contact with the container body 2 in addition to the outer surface side close portion 3f of the bottom portion 3b.
  • the combination of the close contact portion 3f and the close contact portion 2i includes a container main body such as the lower end surface of the attaching / detaching grip portion 3d of the middle container 3 and the upper end surface of the outer container 2 in contact with the intermediate chamber 3 in addition to the combination for sealing the first chamber P. It may be a combination of close portions that prevent liquid leakage to the outside near the opening of the contact portion, and close portions such as a seal ring 8 that protrudes from the intermediate container 3 in the circumferential direction for facilitating movement of the intermediate container 3.
  • a combination of the (projection) and the inner surface of the container body 2 with which it abuts may be used.
  • the two-component mixing container 1 When the two-component mixing container 1 is used, when the middle container 3 is loosened and the middle container 3 is retracted in the direction opposite to the bottom 2b of the container body 2, the two-component mixing container 1 is brought into close contact with each other at the central portion.
  • the close contact portion 2i of the container main body 2 and the close contact portion 3f of the middle container 3 are separated from each other.
  • a space that enables communication between the first chamber P and the second chamber Q appears between the side opening 10 and the second agent moving portion 13 (A), and the second agent B is changed to the first agent A.
  • a seal ring or the like may be used for the close contact portion.
  • the middle container 3 shown in FIG. 7 has a substantially cylindrical shape.
  • the middle container 3 is composed of a plurality of cylindrical portions.
  • the first cylindrical portion X, the second cylindrical portion Y, and the third cylindrical portion Z are gradually reduced in size from above. It continues in this order.
  • the inner diameter and the outer diameter are gradually reduced (see FIG. 10).
  • the third cylinder portion Z (columnar portion) shown in FIG. 7 is slightly tapered downward, it may be a cylinder.
  • the first cylinder part X has an opening 3a (second agent inlet), and an external thread that enables the outer surface of the second cylinder part Y to be screwed with the first cylinder part x of the container body 2 A threaded shape such as part 7 is formed.
  • the second cylindrical portion Y may also serve as the third cylindrical portion Z.
  • Each of these cylindrical portions may include a tapered portion, a cylindrical portion, or the like as necessary.
  • a tapered portion 28 is provided at the boundary between the second cylindrical portion Y and the third cylindrical portion Z of the middle container 3.
  • the third cylindrical portion Z of the middle container 3 has a second agent moving portion 11 (B) having a side opening 10, a wall 25 surrounding the opening 10 from the side, and a bottom of the second chamber Q. 8 and 9, the bottom of the middle container 3 has an outflow guide 12 having a reverse taper shape.
  • FIG. 7 shows an example of a middle container that does not have the outflow guide 12.
  • An upper end surface 2C of the first cylindrical portion x of the container body 2 is in contact with a lower end surface 3e of the attaching / detaching gripping portion of the first cylindrical portion X of the middle container 3.
  • the shape of the middle container 3 is not particularly limited as long as it can be detachably attached to the container body 2, and is arbitrarily selected.
  • the attachment structure of the middle container 3 to the container body 2 may be any structure as long as the first agent A and the second agent B are kept sealed.
  • the middle container 3 preferably has a structure in which the attachment / detachment gripping part 3d and the like are completely integrated with the housing part housed in the container body 2.
  • the middle container 3 does not have to be accommodated entirely in the container body 2. In the example shown in FIG.
  • a part of the middle container 3 is housed in the container main body 2, but the other part (such as the two-component mixing handle part 3 d of the middle container) is externally provided as a detachable grip part 3 d.
  • An external force is applied by a human hand or the like for exposing and retracting the middle container 3 in a direction opposite to the bottom of the container body 2.
  • the shape of the attaching / detaching grip portion 3d of the middle container 3 can be arbitrarily selected.
  • 32 has a handle as shown in FIG. 32 for facilitating the attachment / detachment of the middle container 3, or a groove is formed in order to make it easier to apply force to the outer peripheral part or the lid part of the attaching / detaching gripping part 3d, Patterns or letters that increase resistance may be formed in three dimensions. Since the partial attaching / detaching grip 3d to which an external force is applied is formed integrally with the middle container 3, it is excellent in physical strength and durability.
  • the outer shape of the inner container 3 of the portion accommodated in the container body 2 can be arbitrarily selected.
  • a cylindrical shape, a substantially cylindrical shape, an inverted conical shape (tapered shape) provided with a bottom surface, a polygonal columnar shape, a polygonal pyramid, an inverted shape It may be a truncated cone.
  • a multi-stage shape may be used in which the size gradually decreases toward the bottom.
  • wearing with the container main body 2 can be selected arbitrarily and can be used.
  • the middle container 3 may be colored, colorless, transparent, translucent or the like.
  • the material for the inner container 3 is not particularly limited, and may be resin, metal, glass, or the like. Specific examples include synthetic resins that cause elastic deformation, such as polyethylene, polypropylene, polystyrene, polycarbonate, ABS resin, and methacrylic acid resin.
  • a soft synthetic resin is used for the container body 2
  • a hard synthetic resin is used for the middle container 3
  • a soft synthetic resin is used for the middle container 3
  • the second chamber Q of the middle container 3 accommodates the second agent B and has one or more side openings 10 in the lower part.
  • it forms in the substantially cylindrical shape which consists of a some cylinder part.
  • it has a substantially cylindrical shape in which the first cylinder part, the second cylinder part, and the third cylinder part are continuous in this order.
  • the cross-sectional area becomes narrower toward the first cylinder part, the second cylinder part, and the third cylinder part.
  • the cross-sectional area of the cylinder may be reduced stepwise or may be gradually reduced.
  • the inner shape of the second chamber Q can be arbitrarily selected, and may be a columnar shape, a substantially cylindrical shape, an inverted conical shape (tapered shape) provided with a bottom surface, a polygonal columnar shape, a polygonal pyramid, an inverted truncated cone or the like. There may be.
  • the cross-sectional shape is arbitrary, but a circular shape is preferable.
  • the middle container 3 has the second agent moving portion 11 (B) at the end opposite to the opening 3 a that is the second agent inlet, that is, at the lower position of the second chamber Q.
  • the second agent moving unit 11 (B) includes the bottom 3 b, one or more side openings 10 provided on the side surface, and one or more wall portions 25 located between the side openings 10. .
  • the bottom part 3b has the outflow guide part 12, it does not need to include it.
  • the number of side openings 10 is arbitrary, but about 1 to 10 is suitable, preferably 1 to 4, and more preferably 1 to 3.
  • the shape of the side opening 10 is also arbitrary, and examples thereof include a square, a rectangle as shown in FIG. 7, a circle, a semicircle, a semi-ellipse, a trapezoid as shown in FIG. A slit shape or the like may be used. From the ease of movement of the second agent B, the bottom 3b of the second chamber Q and the lowermost part of the side opening 10 (the place farthest from the opening 3a) should be in contact with each other at least one place. preferable.
  • the end surface surrounding the side opening 10 does not have to be a surface that is horizontal or orthogonal to the major axis direction of the container, and may have, for example, a curved surface or an inclined surface as shown in FIG. 31A.
  • the second agent B is introduced from the opening 3a of the middle container 3 by a method selected arbitrarily.
  • the middle container 3 is sealed by an arbitrary method in order to prevent the second agent B from leaking.
  • the opening 3 a of the middle container 3 is sealed by the covering portion 4.
  • the sealing method can be selected arbitrarily.
  • the fitting plug 19 as shown in FIG. 33A may be inserted through the opening 3a as a lid, or as shown in FIG. 32, a handle 3d ′ having an arbitrary shape is attached to the lid 15 by a method such as welding. It may be fixed to the middle container 3.
  • the material and shape of the covering and lid such as a hermetic seal can be arbitrarily selected.
  • metal foil, polymer, paper, resin, and other organic materials and inorganic materials may be arbitrarily selected.
  • a combination of metals and polymers may be used.
  • surface coating or surface treatment may be performed with an arbitrary material such as a resin.
  • Heat or adhesive may be used for sealing to the middle container 3.
  • the shape of the hermetic seal or the lid may be a circular shape, an oval shape, a substantially circular shape, a triangular shape, a substantially triangular shape, a square shape, a trapezoidal shape, a water droplet shape, or the like.
  • a lid part partially connected to the middle container may be provided, and after the two agents are accommodated, the lid may be closed again.
  • the closed lid may be welded or the like, or may be structured so as not to easily come off after the lid is closed.
  • the thickness and shape of the hermetic seal and lid can be selected arbitrarily. It is also preferable to provide a protrusion as a handle on the covering such as the hermetic seal or the lid in order to facilitate adhesion and peeling. It is good also as a structure which a coating material and a lid
  • the sealed portion of the middle container 3 is not necessarily provided at the end 3a. If necessary, for example, a lid having a grip-type attaching / detaching gripping portion is welded somewhat inside the opening 3a of the middle container 3 or the like. Thus, a sealed position may be provided.
  • the third substance D is added to the second agent B, and then mixed with the first agent A.
  • the second agent (B + D) may be mixed.
  • the third substance D may be a solid or a liquid. However, in that case, care must be taken so that liquid does not spill out from the opening of the middle container. It is preferable that the removed covering or lid (sealed portion) can be attached or attached again. Moreover, you may remove the coating
  • the middle container 3 has a seal ring 8 (protrusion 3 g) at a position above the side opening 10.
  • a seal ring 8 protrusion 3 g
  • at least one protruding portion 3g close contact portion 3f
  • a groove corresponding to the seal ring 8 may be provided in the middle container 3, or a groove may be provided in the container main body 2.
  • the shape, number, and position of the protrusion 3g are arbitrary. In order to facilitate the movement of the middle container 3, about 2 to 6 hemispherical or other small protrusions may be provided. Moreover, if the protrusion which continues over circumferential directions, such as a seal ring, is provided, the effect which prevents the leakage of the 1st agent A and the 2nd agent B at the time of storage will also be acquired. By providing such a projection 3g, the projection 3g can move on the smooth surface portion of the container body 2 in the vertical direction, so that the contact area between the container body 2 and the middle container 3 can be reduced. During mixing, the middle container 3 can be moved smoothly.
  • the middle container 3 preferably has an outflow guide 12.
  • the shape and size of the outflow guide portion 12 can be arbitrarily selected.
  • a conical shape that spreads downward (first chamber P direction), a truncated cone shape shown in FIG. 10, a polygonal truncated cone shape shown in FIG. 22A, a quadrangular pyramid, a triangular pyramid, a hemisphere shown in FIG. Take as an example. It is preferable that it is the reverse taper shape extended toward the downward direction, and the upper part of the outflow guide 12 may be provided with a flat surface or an oblique surface.
  • the outflow guide 12 may simply have a shape with an inclined bottom surface or the like, as long as it guides the flow to the side opening 10.
  • the outflow guide part 12 of the middle container 3 may be a lid part of the first chamber P of the container body 2, and the first agent A may be confined in the first chamber P.
  • the manufacturing method of the middle container 3 can be arbitrarily selected. For example, integral molding may be performed using molding such as extrusion molding or injection molding, and some parts may be combined and bonded or bonded by any method such as welding.
  • the container main body 2 is a hollow cylinder with a bottom, and includes an opening 2a, a bottom 2b, a middle container housing 2h for housing a part of the middle container 3, and the bottom 2b. It has a room P.
  • the lid of the first chamber P is formed by the bottom 3b of the second chamber Q of the middle container 3 (see FIG. 3).
  • the container body 2 has a substantially cylindrical shape.
  • the container body 2 is composed of a plurality of cylindrical portions.
  • the 1st cylinder part x, the 2nd cylinder part y, and the 3rd cylinder part z are formed as a substantially cylindrical shape which continued in this order.
  • the inner diameter and the outer diameter gradually decrease.
  • the inside of the third cylinder part becomes the first chamber P, and the first cylinder part x and the second cylinder part y having the opening 2a function as the middle container housing part 2h for housing the middle container 3. To do.
  • a tapered portion 5 (stepped portion) is provided between the first tube portion x and the second tube portion y and between the second tube portion y and the third tube portion z.
  • a screwing structure portion (female screw portion 14) that enables screwing with the inner container is provided inside the first tube portion x.
  • a projecting portion is provided on the lower portion of the outer surface of the first cylindrical portion x in consideration of workability when the container is held in the hand.
  • the second tube portion may also serve as the third tube portion, and each tube portion may include a tapered portion, a columnar portion, or the like as necessary.
  • the cylindrical portion y is slightly tapered but may be a cylinder. You may design the 2nd cylinder part and the 3rd cylinder part of the middle container 3 so that it may be accommodated in the container main body 2 exactly.
  • the shape of the container main body 2 of the present invention, the materials and parts used, the color, and the like are not limited and can be arbitrarily selected.
  • a threaded structure or the like may be employed, or one or more recesses (grooves) may be formed in the container body 2 and one or more protrusions (projections) may be formed in the middle container 3 to engage with each other.
  • external force may be applied to remove the contract, and the two agents may be mixed.
  • one or more convex portions may be formed in the container body 2 and one or more concave portions may be formed in the middle container 3.
  • the number, size, and shape of the concave and convex portions can be arbitrarily selected. For example, it may be any number from 1 to 20.
  • the shape viewed from above may be a circle, a substantially circle, a square, a substantially square, a triangle, a substantially triangle, or other polygons. *
  • the outer shape of the container main body 2 can be arbitrarily selected, and may be a substantially cylindrical shape as shown in FIG. 12, or an inverted conical shape having a cylindrical shape as shown in FIG. 31A or a bottom surface as shown in FIG. 30 ( Tapered shape), polygonal column shape, or polygonal pyramid.
  • the inner surface portion of the container main body 2 may have a screwing structure portion, a flange portion, and a groove portion at an arbitrary position for enabling attachment to the middle container 3.
  • a groove portion may be formed, or a pattern, characters, or the like that increases resistance may be formed in three dimensions.
  • the inner shape of the container body 2 can be arbitrarily selected from a substantially cylindrical shape as shown in FIG. 12, and a cylindrical shape as shown in FIG. 31A or an inverted conical shape (tapered shape) provided with a bottom as shown in FIG. ), A polygonal column shape, or a polygonal pyramid.
  • the container body 2 may be colored, colorless, transparent, translucent, or the like. It does not specifically limit as a material of the container main body 2, Resin, a metal, glass etc. may be sufficient. Specific examples include synthetic resins that cause elastic deformation, such as polyethylene, polypropylene, polystyrene, polycarbonate, ABS resin, and methacrylic acid resin.
  • the middle container 3 and the container body 2 may be formed of the same material or different materials. When a soft synthetic resin is used for the container body 2, a hard synthetic resin is used for the middle container 3, or when a hard synthetic tree is used for the container body 2, a soft synthetic resin fat may be used for the middle container 3. It is preferable for maintaining the liquid-tight structure of the two-component mixing container.
  • the first chamber P of the container body 2 is located at the bottom of the container body 2 and houses the first agent A. After containing the first agent A, it is sealed by the bottom of the second chamber Q of the middle container 3.
  • the middle container housing portion 2 h of the container body 2 accommodates the middle container 3 and allows communication between the first chamber P and the second chamber Q when the middle container is retracted. It has the 2nd agent movement location 13 (A) which is.
  • the inner cross-sectional shape perpendicular to the longitudinal direction of the container of the second agent moving portion 13 (A) is larger than the outer cross-sectional shape of the outer surface side close contact portion at the bottom of the middle container. This is because the second agent B coming out from the side opening 10 of the middle container 3 can move to the first chamber P of the container body 2 via the second agent movement point 13 (A), and the middle container 3 means that the container body 2 can be moved upward.
  • the container main body 2 has an inner cross-sectional shape smaller than the outer cross-sectional shape of the outer surface side close contact portion 3f at the bottom portion 3b of the middle container 3 below the second agent moving portion 13 (A), and the middle container bottom portion is It has the contact part 2i (close part) which contacts.
  • the middle container accommodating part 2h of the container main body 2 has said 2nd agent movement location 13 (A).
  • the second agent moving portion 11 (B) of the middle container 3 moves to the second agent moving portion 13 (A) of the container body 2, and the first chamber P and the second chamber Q are moved.
  • a communication part is formed in the first chamber P so that the second agent B can move into the first chamber P.
  • the shape of the 2nd agent movement location 13 (A) is arbitrary. For example, as shown in FIG. 3, if there is a portion above the bottom portion 3 b of the middle container 3 that has an inner cross section larger than the outer cross-sectional shape of the outer surface side close contact portion 3 f of the middle container bottom portion 3 b, all of the portions are the second agent. It may be considered as the moving part 13 (A). As shown in FIG. 30, if the middle container 3 and the container body 2 are tapered so that they are in close contact with each other, the second agent moving portion 13 (A) is a tapered portion above the bottom of the middle container 3. . As 2nd agent movement location 13 (A), as shown to FIG.
  • the container main body 2 shown in FIG. 31A has almost the same inner cross section as the maximum outer cross section of the outer surface side intimate portion 3f of the bottom 3b of the middle container 3, but the container main body 2 is in the horizontal outer direction in the middle of the cylinder. It has the space 29 (groove part) which protrudes continuously in the circumferential direction.
  • the size and shape of the space 29 can be arbitrarily selected and function as the second agent moving portion 13 (A).
  • the inner cylinder portion of the container body 2 is formed with a threaded shape such as a female screw portion 14 as necessary. The position is arbitrary.
  • the manufacturing method of a container main body can be selected arbitrarily.
  • integral molding may be performed using molding such as extrusion molding or injection molding, and some parts may be bonded by any method such as combination welding.
  • the container body 2 is erected and the first agent A is added into the first chamber P from the opening 3a.
  • the addition method and addition amount are arbitrary, it is preferable that it is the method and quantity which do not adhere to another part and are settled in the 1st chamber P.
  • the middle container 3 is accommodated from the opening 3a of the container body 2 from the bottom 3b side. At this time, the middle container 3 is fixed to the container body 2 by an arbitrarily selected mounting method, for example, a screwing structure or the like provided to fix each other.
  • the bottom part 3b of the middle container 3 is pushed into the taper part (funnel-shaped part) of the container body 2 by a force applied by screwing or the like from the upper direction to the lower direction, becomes the ceiling of the first chamber P, and the first agent is Seal liquid tightly.
  • the first agent A is sealed by the bottom portion 3b due to the close contact between at least one inner surface side close portion 2i of the container body 2 and at least one outer surface side close portion 3f of the middle container 3.
  • an O-ring or the like may be further provided.
  • a convex structure portion, a seal ring 8 shown in FIG. 14 a packing, an O-ring, or the like may be provided over the entire circumference of the bottom portion 3 b of the middle container 3. As shown in FIG.
  • the upper end surface 2i of the container body 2 may be brought into contact with the lower end surface 3f of the cylindrical exposed portion (detachable gripping portion) of the middle container 3 to improve the sealing state.
  • a packing or an O-ring may be provided on the lower end surface of the cylindrical exposed portion 3d of the middle container 3 or the upper end surface of the container body 2 as shown in FIG.
  • a concave structure portion or a convex structure portion may be provided.
  • a structure in which a groove portion is provided on the lower surface of the cylindrical exposed portion of the middle container 3 and the upper end portion of the container body 2 is covered may be employed.
  • the container body 2 is made of a material having excellent mechanical strength and a certain degree of flexibility, the container body 2 having a slightly smaller cross-sectional size than the cross-sectional size of the bottom of the middle container 3 when the middle container 3 is pushed in.
  • the bottom of the middle container 3 can be fixed at the inner position. That is, the first agent A contained in the first chamber P may be sealed by the bottom portion of the middle container 3 expanding and closely contacting the container body 2. Or you may provide a level
  • the stepped portion surrounds the groove 18 over the entire circumference for receiving the end portion 17 of the bottom 3b of the intermediate container 3 as necessary.
  • a protrusion 18 ′ may be provided.
  • the second agent B is introduced from the opening 3a of the middle container 3.
  • the charged second agent B is in contact with a part of the inside of the container main body 2, the close contact portions 2 i and 3 f between the container main body 2 and the middle container 3, which are positioned below it, There is no leakage from the boundary of the container body 2 to the bottom.
  • the opening 3a of the middle container 3 is sealed.
  • the sealing material and method are arbitrary, but it is necessary that the second agent B contained therein does not leak out.
  • the size of the two-component mixing container 1 of the present invention is not particularly limited. From the viewpoint of ease of use, the height of the two-component mixing container 1 is generally 1 cm or more and 50 cm or less, preferably 3 cm or more and 15 cm or less, and the width and depth are 0.3 cm or more and 15 cm or less, respectively. Is generally 0.5 cm or more and 5 cm or less.
  • An arbitrary structure may be further provided on the bottom of the container body 2. For example, an opening / closing part may be provided, or another structure may be provided. As shown in FIG.
  • an opening 2d may be provided at the bottom, and a lid 24 that can be attached to and detached from the opening 2d by screwing or the like may be provided.
  • the outer wall near the bottom of the container main body 2 is provided with a groove such as a V-shaped or a cut in the lid in the circumferential direction, and the bottom is cut out after mixing the two agents, or a partial cut is made It is also possible to remove the bottom from the bottom of the container by removing the bottom as a lid while partly joined to the container main body by providing a portion with no gap.
  • the liquid which can be accommodated in the 2 agent mixing container of this invention can be selected arbitrarily. This can be done by selecting the container material according to the properties of the liquid to be stored. Specific examples of the liquid include an aqueous sodium nitrite solution, an aqueous acetic acid solution, an aqueous peroxide solution, and a Tris buffer.
  • a solid or viscous material may be accommodated instead of the liquid as long as mixing is possible. Either one may be a solid and one may be a liquid.
  • the shape of the individual can be arbitrarily selected, and a suitable shape such as a powder, a tablet, and a crushed body can be selected.
  • FIG. 30 is a side sectional view of the two-component mixing container 1 showing an example of the present invention.
  • the container body 2 and the middle container 3 are generally tapered.
  • the middle container 3 has a tapered portion including one side opening 10 and a bottom 3b, and the side of the bottom functions as the outer surface close contact 3f.
  • the container body 2 has a tapered portion that is the middle container housing portion 2h, and the middle container 3 and the tapered portion of the container body 2 are at least partially in contact with each other, and when the middle container of the middle container is retracted, A gap is formed between the taper portions of each other.
  • the middle container 3 is attached to the container body 2 by screwing.
  • the middle container 3 includes a first cylinder portion having an opening 3 a, a second cylinder portion having a screwed structure formed on the outer surface, and a third cylinder portion having a side opening 10.
  • the second agent storage part (second chamber Q) is formed inside the first cylinder part, the second cylinder part, and the third cylinder part of the middle container, and the tapered part and the first cylinder in the first cylinder part.
  • the taper part which connects the inside of a part and the inside of a 2nd cylinder part, and the taper part formed in the continuous 2nd cylinder part and the inside of a 3rd cylinder part are comprised.
  • the middle container 3 does not include an outflow guide portion.
  • the side surface of the second container moving portion 11 (B) of the middle container including the side opening 10 and the bottom 3 b of the middle container 3 is in close contact with the inner surface of the container body 2, and therefore the second agent B leaks out. There is nothing.
  • the first chamber P is completely sealed by the bottom of the middle container 3.
  • a seal ring or the like may be provided at the bottom of the middle container 3.
  • the upper surface of the middle container is sealed with the covering material 4.
  • the container body 2 has a tapered shape and is provided with a screwing structure for mounting the middle container 3 on the inner surface. By rotating the gripping part 3d for attachment / detachment and moving the middle container 3 upward, the side opening 10 also moves upward, and the first chamber P and the second chamber Q communicate with each other.
  • the inner shape of the container body 2 may be formed slightly smaller than the outer shape of the middle container 3.
  • the container main body 2 has an appropriate flexibility, and when the middle container 3 is pushed in by screwing, the container main body 2 spreads while maintaining an appropriate hermeticity to such an extent that it does not break, close to each other, and the contents leak.
  • a two-component mixing container 1 without water is formed.
  • the bottom 3b of the middle container 3 is moved to the side of the second agent moving portion 13 (A) of the container body by loosening the screwing of the middle container, and a space is formed beside the bottom of the middle container 3. From that space, the second agent B moves into the first chamber P and mixes with the first agent A.
  • a notch 26 is provided in the circumferential direction at a position above the bottom of the container body 2, and if necessary, the bottom can be cut out and the mixture can be taken out therefrom. If the two parts are mixed and then screwed again, and the bottom part is cut upward, the hand will not be soiled by the mixture during cutting.
  • the cut 26 may be provided from the inside or from both the outside and inside.
  • FIG. 31A is a side sectional view of a cylindrical two-component mixing container 1 showing an example of the present invention.
  • the appearance of the two-component mixing container 1 is a simple cylindrical shape.
  • the middle container 3 has a columnar portion including the side opening 10 and the bottom 3b, and has an outer surface close contact portion 3f on the side of the bottom 3b.
  • the middle container housing portion 2h of the container body 2 has a groove portion 29 formed on the inner wall, and has a cylindrical portion that contacts the outer surface side close portion 3f of the middle container 3 below the groove portion 29. When the middle container 3 is retracted, a gap is formed between the columnar portion of the middle container 3 and the groove portion of the columnar portion of the container body 2.
  • the container body 2 includes a first cylinder part, a second cylinder part, and a third cylinder part.
  • the first cylinder part has an opening 2a and a screwed structure part
  • the second cylinder part has a donut shape on the inner wall. It has the provided space part 29, and a 3rd cylinder part forms the cylindrical 1st chamber P.
  • the middle container 3 includes a first cylindrical portion having an opening 3a, a second cylindrical portion having a screwed structure, a third cylindrical portion having a side opening 10 and a bottom surface 3b, and a cylindrical second chamber therein. Q is formed.
  • the first cylindrical portion of the middle container 3 is a detachable gripping portion 3 d and has a larger outer periphery than the adjacent second cylindrical portion, and is the same as the outer periphery and outer shape of the container body 2. Therefore, when the middle container 3 is attached to the container main body 2, a smooth integrated surface is provided. At the time of mounting, the upper edge of the first cylinder part of the container body 2 and the lower edge of the first cylinder part of the middle container 3 come into contact with each other for sealing, but a packing 9 is provided between them to improve the sealing performance. ing.
  • the mixing container 1 does not include an outflow guide portion.
  • a groove (contact portion) is provided in the circumferential direction near the inner center of the container body 2, and a protrusion (contact portion) at the bottom of the middle container 3 is provided in the groove so as to protrude outward in the circumferential direction.
  • 3g) is signed.
  • the container body 2 is provided with a contact portion 2i in contact with the protrusion 3g of the middle container 3 and the middle container as a groove.
  • the groove portion is not provided in the container body, and the protrusion 3g
  • the first chamber P may be kept sealed.
  • An O-ring may be used as the contact portion 3g.
  • the container main body 2 may be appropriately flexible, and the maximum cross section of the middle container 3 may be slightly larger than the inner diameter of the container main body 2 to maintain the sealed state of the first storage chamber P. Some of the above may be combined.
  • the middle container 3 is provided with two side surface openings 10 on the bottom side surface of the middle container 3.
  • the upper edge portion of the side opening 10 is provided with an inclined surface directed downward. The inclined portion may be provided at the lower edge portion of the side opening 10 or both.
  • the intermediate container 3 has a distance from the bottom 3b of the second chamber Q having the outer surface side close portion 3f that keeps the first chamber P fluid-tight and the bottom 2e of the container body 2 from the distance to the outer surface close portion 3f. And a second agent moving part 11 (B) having one or more side openings 10 in a long position.
  • the first chamber P of the container body 2 is completely sealed by the bottom of the second agent moving part 11 (B) of the middle container 3.
  • the upper surface of the middle container 3 is sealed with a covering material, and the container body 2 is provided with a screwing structure for mounting the middle container 3 on the inner surface.
  • the container main body 2 of the two-component mixing container 1 in an unused state is provided with a space portion 29 that is located above the side opening 10 of the middle container 3 and located below the screwing structure and that is continuous in the inner circumferential direction. It has been.
  • a space 29 appears on the side of the bottom 3b of the middle container 3.
  • the first chamber P and the second chamber Q communicate with each other through the side surface opening portion 10, from which the second agent B moves into the first chamber P, and the first agent A and Mix.
  • the shape of the space 29 may be any as long as the second agent B can move to the first chamber P by communication, and for example, the cross section is a quadrangle, a rectangle, a semicircle, a semi-ellipse, a trapezoid, As shown in FIG. 31B and FIG. 31C, it may be a semicircle, a semi-ellipse, a triangle, or the like.
  • the space may be provided with an inclined portion so as to facilitate the movement of the second agent B, and may be continuous in a donut shape in the circumferential direction, or one or more spaces may be provided separately.
  • the first chamber P is sufficiently sealed by the bottom portion 3b of the middle container 3, in addition to the space portion 29, the second and third tube portions of the middle container 3 and the second tube portion of the container body 2 There may be a gap as shown in FIG. 31B or FIG. 31C between them.
  • FIG. 32 is a side sectional view of the two-component mixing container 1 showing an example of the present invention.
  • the container main body 2 has the same structure as the container main body 2 shown in FIG.
  • the middle container 3 does not have the first cylinder part of FIG. 1 and is configured by a second cylinder part and a third cylinder part.
  • the second cylindrical portion of the middle container 3 is designed so that a gap formed between the first cylindrical portion of the container main body 2 and a tapered portion continuous thereto is reduced.
  • a lid portion 15 having a flat handle 3d '(a gripping portion for attachment / detachment) is formed.
  • the handle shape is arbitrary. After accommodating the 1st agent A in the container main body 2, the middle container 3 is mounted
  • FIG. 33A is a side sectional view of the two-component mixing container 1 showing an example of the present invention.
  • the middle container 3 has a cylindrical portion including a side opening 10 and a bottom 3b, and the outer-surface-side close portion 3f of the bottom is located on at least one of the side surface and the bottom surface of the bottom 3b.
  • the middle container housing portion 2h of the container body 2 has a stepped portion 30 that comes into contact with the outer surface side close portion 3f of the middle container 3, and when the middle container 3 is retracted upward, the cylindrical portion and the stepped portion are formed. A gap is formed between the portions 30.
  • the angle of the stepped portion 30 can be arbitrarily selected.
  • the container main body 2 has a donut-shaped groove 18 that receives the edge 17 of the bottom 3b of the middle container 3 as a stepped portion 30 at the boundary between the second cylindrical portion and the third cylindrical portion, and a protrusion 18 ′ at the inner end thereof. Except for the provision, it has the same structure as the container body 2 shown in FIG. With the presence of the groove and the protrusion shown in FIG. 33b, the sealing property of the first chamber P can be obtained.
  • the protrusion 18 ′ may be omitted. You may provide packing etc. in a groove part.
  • the attaching / detaching grip portion 3d in the first tube portion of the middle container 3 has a groove portion 31 for accommodating the upper end portion of the first tube of the main body container 2 and its edge portion on the lower side.
  • the presence of the edge and the groove 18 can enhance the effect of preventing leakage of the second agent B from the upper boundary between the main body container 2 and the middle container 3.
  • the groove 31 may be provided with packing or the like.
  • the opening 3 a of the first cylinder portion of the middle container 3 is sealed with a fitting cap 19.
  • the depth of insertion can be set arbitrarily. This cap may or may not be adhered. You may arrange
  • the two-component mixing container 1 of the present invention can be used for mixing a plurality of materials as required.
  • both the middle container 3 and the container body 2 or one of them may have both functions of the middle container and the container body.
  • FIG. 34 is a container obtained by improving the two-component mixing container 1 of the present invention shown in FIG.
  • the bottom of the container body 2 is formed in the same manner as the shapes of the second cylinder part and the third cylinder part of the middle container 3 with a reduced size.
  • a second outer container 2 ′ is provided which is the same as the container body 2 shown in FIG.
  • the second outer container 2 ′ includes a third chamber R, which is sealed by the bottom 3 b ′ of the container body 2.
  • the first chamber P, the second chamber Chamber Q and third chamber R are completely sealed.
  • the combination of the middle container 3 and the outer container 2 and the combination of the outer container 2 and the second outer container 2 ′ are mounted by screwing, but other mounting methods may be adopted.
  • the outer container 2 has a circumferential step 27 that is in close contact with the upper end of the second outer container 2 ′. Is provided. Sealing or the like may be used here.
  • the third agent C is added to the outer container 2 ′.
  • the first agent A is added to the outer container 2.
  • the inner container 3 is attached to the outer container 2, the second agent B is added, and finally the cover material 4 is sealed.
  • the handle 3 d of the middle container 3 is turned to loosen the screwing of the middle container 3 and the outer container 2, and after mixing the first agent A and the second agent B, Holding the container 2 and the outer container 2 ', the screwing of the outer container 2 and the outer container 2' is loosened.
  • the two agents contained in the separated state in the two-component mixing container 1 according to the present embodiment are, for example, liquid A (agent A) and liquid B (agent B) that are mixed and used at the time of diagnosis.
  • the two agents are mixed to extract a group A ⁇ -hemolytic streptococcal antigen that is an infectious disease.
  • the two-component mixing container 1 according to the present embodiment shown in FIGS. 13 and 14 includes a bottomed container body 2 in which the liquid A, which is one of the two components, is stored in the lower part, and B, which is the other of the two components.
  • a bottomed middle container 3 that contains the liquid and is mounted in the container body 2, and a covering material 4 that seals the mouth 3 a of the middle container 3 are provided.
  • the middle container 3 has a cylindrical portion including the bottom 3b, and has an outer surface side intimate portion 8 (3f) on the side surface of the bottom 3b.
  • the middle container housing portion 2h of the container body 2 has a tapered portion and a columnar portion that is located below and contacts the outer surface side intimate portion 8 (3f) of the middle container. When retracted, a gap is formed between the cylindrical portion of the middle container and the tapered portion 5 of the container body.
  • the cylindrical portion may have a slightly tapered shape.
  • the portion of the container main body 2 that stores the A liquid is referred to as a first chamber P
  • the inside of the middle container 3 that stores the B liquid is referred to as a second chamber Q.
  • the container body 2 has a mouth portion 2a at the upper end and has a tapered cylindrical shape whose inner diameter gradually decreases toward the bottom portion 2b, and a tapered step portion 5 which is inclined more than the upper and lower portions in the middle portion. Is formed. A part of the tapered cylindrical inner surface on the lower side of the stepped portion 5 is a tapered contact surface 6 that forms an inner surface close contact portion. (See FIG. 14).
  • the middle container 3 shown in FIGS. 14 and 16 is formed in a tapered cylindrical shape whose inner diameter gradually decreases from the mouth portion 3a toward the bottom portion 3b.
  • a seal ring 8 is formed as a close contact portion that fits the tapered contact surface 6 of the container body 2 and seals the entire periphery in a liquid-tight manner.
  • Both the container body 2 and the middle container 3 are formed of a synthetic resin that can be elastically deformed. For this reason, when the seal ring 8 is fitted to the taper contact surface 6, the first chamber P on the bottom 2 b side of the container body 2 and the second chamber Q including the inner container 3 on the mouth 2 a side are liquid-tight. Separate and seal.
  • a male screw portion 7 is formed on the outer peripheral surface of the upper portion of the middle container 3.
  • an opening 10 is formed on the side of the mouth 3a of the cylindrical outer peripheral surface 3c so as to communicate the inside and outside. It is sufficient that at least one opening 10 is provided in the circumferential direction. In the case of using two or more, it is preferable that the width of the wall portion 11 is reduced, so that the liquid B flows more easily. Therefore, it is preferable that the opening portion 10 has a tapered trapezoidal shape (see FIG. 16). In this embodiment, three tapered trapezoidal openings 10 are formed at equal intervals across the wall 11. For example, a conical (or conical) outflow guide 12 is formed on the bottom 3b in the middle container 3 (see FIG. 17). This shape is preferable because it is not necessary to adjust the position facing the opening 10.
  • the container body 2 is formed with an internal thread portion 14 that is liquid-tightly engaged with the external thread portion 7 on the outer peripheral surface of the intermediate container 3 on the inner surface.
  • the female threaded portion 14 of the container body 2 is notched so that when the screwing with the male threaded portion 7 of the middle container 3 is loosened, air flows out and flows through the gap between the middle container 3 and the container body 2. Provided (not shown).
  • the middle container 3 is inserted into the container body 2, and is fitted to the seal contact surface 6 of the container body 2 by the seal ring 8 of the middle container 3. It is in a tightly sealed state.
  • the outer peripheral surface of the middle container 3 and the inner surface of the container main body 2 are in contact with each other over the entire periphery.
  • a ring-shaped gap K is formed between the inner surface including the stepped portion 6 of the container body 2 and the middle container 3 (see FIG. 21A).
  • the two-component mixing container 1 contains the liquid A in the first chamber P formed between the bottom 2b in the container body 2 and the middle container 3, and the bottom of the middle container 3
  • the seal ring 8 is sealed in a liquid-tight manner.
  • Liquid B is sealed in the second chamber Q in the middle container 3 in a liquid-tight manner.
  • a part of the liquid B flows out from the opening 10 into the gap K between the container main body 2 and the container.
  • the two liquids A and B are held in a separated state regardless of the posture of the two-pack mixing container 1.
  • the middle container 3 moves when the middle container 3 is lifted by loosening the middle container 3 from the state in which the middle container 3 is screwed into the container body 2 and sealed in a liquid-tight manner. For this reason, the taper contact surface 6 and the seal ring 8 are separated from each other, and the middle container 3 and the first chamber P of the container body 2 communicate with each other through the gap K and the opening 10 (see FIG. 20).
  • the material of the two-component mixing container 1 is made of synthetic resin.
  • the container body 2 is made of low density polyethylene
  • the middle container 3 is made of polyethylene
  • the cap 4 is made of polypropylene or the like.
  • the two agents of A liquid and B liquid can be selected arbitrarily.
  • it is a reagent for extracting group A ⁇ -hemolytic streptococcal antigens.
  • solution A is an aqueous sodium nitrite solution
  • solution B is an aqueous acetic acid solution.
  • the amount of liquid A and liquid B accommodated in the two-component mixing container can be arbitrarily set.
  • the amounts of the liquid A and the liquid B are both 200 to 300 ⁇ l.
  • the two-component mixing container 1 has the above-described configuration. Next, the usage method will be described. First, in the two-component mixing container 1 shown in FIGS. 13 and 14, the liquid A is accurately measured and injected into the first chamber P before the middle container 3 is inserted into the container body 2. Thereafter, the middle container 3 is inserted, and the seal ring 8 on the lower outer peripheral surface 3c is fitted to the taper contact surface 6 to be liquid-tightly attached. Subsequently, the B liquid is accurately measured and injected into the middle container 3.
  • the liquid B preferably has a liquid level at a position higher than the opening 10, but the liquid level may be in the middle of the opening 10.
  • the container body 2 Since the container body 2 is liquid-tightly sealed by the taper contact surface 6, the bottom of the middle container 3, and the seal ring 8, the B liquid is separated and held from the A liquid.
  • the internal thread portion 14 on the inner side surface of the container body 2 is screwed with the external thread portion 7 of the middle container 3, the container is liquid-tightly sealed by the subsequent covering 4. Therefore, even if the two-component mixing container 1 falls during storage or transportation, the liquid A and the liquid B are not mixed and the liquid B does not leak to the outside.
  • the two-component mixing container 1 When the two-component mixing container 1 is used, for example, when diagnosing a specimen, if the two-component mixing container 1 is loosened from the sealed state of the two-component mixing container 1 shown in FIG. Part of the container body 2 is disengaged (see FIG. 21B), and the middle container 3 moves in a direction away from the container body 2. As a result, the seal ring 8 of the middle container 3 moves away from the tapered contact surface 6 of the container body 2 and moves to the step portion 5. A communication part is formed between the container body 2 and the middle container 3, and the gap K is also widened. Due to the existence of the gap K and the communication part, the liquid B in the middle container 3 flows and passes through the opening 10 to form a gap. It passes through K and falls into the first chamber P of the container body 2.
  • the B liquid does not flow out into the first chamber P from the wall surface 11 existing adjacent to the opening 10 of the middle container 3.
  • the air on the liquid A side smoothly flows into the gap K. Therefore, in the first chamber P, the inflow of the B liquid and the air replacement occur, and the B liquid smoothly flows into the first chamber P in the container body 2 and mixes with the A liquid.
  • the air in the first chamber P that has flowed into the gap K flows into the middle container 3 from at least one of the three openings 10 according to the outflow of the B liquid in the middle container 4. The inflow of air is performed smoothly, and the B liquid in the second chamber Q of the inner container 3 is smoothly expelled from the opening 10.
  • the B liquid in the middle container 3 is guided by the frustoconical outflow guide portion 12 to the opening 10 at the position facing the outflow guide portion, so that the container body 2 can be smoothly passed through the opening 10. It falls into the first chamber P inside, and further mixes with the A liquid. Further, when the middle container 3 is loosened, part of the air inside flows out from between the male threaded portion 7 and the female threaded portion 14 through the gap between the container main body 2 and the middle container 3. At the same time, external air flows through the gap between the male screw portion 7 and the female screw portion 14 and flows into the middle container 3 from the opening 10.
  • the liquid A and the liquid B are mixed in the first chamber P in the container body 2 due to the pressure difference between the inside and outside of the inner container 3 and the decrease in the liquid level of the liquid B. It is done. In this way, the A liquid and the B liquid are mixed in the first chamber P in the container body 2. Then, the middle container 3 is removed from the container main body 2, and the cotton swab with the specimen adhering to the cotton ball is immersed in the liquid mixture of the liquid A and liquid B. In this state, the specimen attached to the cotton balls is extracted into the mixed solution by squeezing the container body 2 with a finger from the outside or shaking the cotton swab in the mixed solution.
  • the liquid mixture from which the specimen has been extracted can be used for diagnosis by immunochromatography.
  • a diagnosis can be made by immersing a dipstick-type immunochromatographic reagent in a mixed solution from which a specimen has been extracted.
  • the diagnosis may be made by dropping the mixed liquid from which the specimen has been extracted from the two-component mixing container 1 onto a measuring instrument by immunochromatography.
  • the two-component mixing container 1 can accurately and easily mix the liquid A and the liquid B, which are accurately measured in advance and stored in a separated state, by loosening the middle container 3. .
  • an opening 10 was formed in the middle container 3 with the wall portion 11 sandwiched along the circumferential direction thereof. Therefore, when mixing the two agents, the B liquid is caused to flow into the one chamber P in the container main body 2 through the opening 10 of the middle container 3, and the air in the one chamber P becomes a wall portion of the middle container 3. 11 and expelled through the gap K between the two. Therefore, liquid A and liquid B are smoothly mixed.
  • the liquid B and the air in the first chamber P are smoothly replaced by the opening 10 and the wall 11 of the middle container 3.
  • the seal ring 8 of the middle container 3 that holds the liquid A and the liquid B in a separated state is fitted to the taper contact surface 6 of the container body 2 to separate the liquid from the first chamber P and the second chamber Q. It can be sealed tightly, and can be separated easily and reliably by loosening the cap 4.
  • 22A and 22B show a modified example of the outflow guide portion 12.
  • the outflow guide 12A shown in FIG. 11A has a triangular frustum shape. It may be a triangular pyramid shape. In order to help outflow, each side surface (plane) of the triangular frustum is preferably provided at a position facing the opening 10.
  • the outflow guide 12B shown in FIG. 11B is formed in a substantially hemispherical shape. It is not necessary to adjust the position of the shape facing the opening 10.
  • FIGS. 23A to 25 show a two-component mixing container 20 according to a second embodiment of the present invention.
  • the difference from the first embodiment is that the bottom 2b of the container body 2 of the two-component mixing container 20 is not sealed, has an opening 2d, and is provided with a filtering filter 21 inside. Is a point.
  • the liquid mixture of A liquid and B liquid can be dripped through the filter 21 for filtration.
  • the nozzle 22 for dripping which has a stepped cylinder part shape is integrally formed in the lower part of the container main body 2.
  • Two or more appropriate numbers of ribs 23 are formed on the outer peripheral surface at a predetermined interval. With this rib 23, fitting adjustment with the sealing cap 24 can be easily performed.
  • a sealing cap 24 is liquid-tightly fitted outside the nozzle 22.
  • the sealing cap 24 prevents the liquid mixture of the liquid A and the liquid B from leaking through the nozzle 22.
  • Four ribs 23 may be provided as shown in FIG. Further, the nozzle 22 and the sealing cap 24 may have a screwed structure.
  • the two-component mixing container 20 when the middle container 3 is separated upward from the fitting state with the container main body 2, the B liquid flows into the first chamber P of the container main body 2, and the A liquid and Mix. Thereafter, the mixed solution further passes through the filter 21 for filtration.
  • the filtering filter 21 may not be provided. Then, by removing the sealing cap 24 from the nozzle 22, the mixed solution in the nozzle 22 is dropped downward, for example, on a diagnostic agent by immunochromatography (not shown). And it can use for a diagnosis etc.
  • FIGS. 27, 28, and 29 show other modified examples of the container body 2.
  • FIG. These modifications relate to the two-component mixing container 1 that mixes the liquid A and the liquid B in the container body 2.
  • the container body 2 shown in FIG. 27 has a bottom 2e formed in a horizontal shape. A gap is formed below it.
  • the container body 2 shown in FIG. 28 has a bottom 2f formed in a hemispherical shape.
  • the container body 2 shown in FIG. 29 has a bottom 2g formed in an inverted funnel shape.
  • the bottom part of the main body container such as the bottom parts 2e to 2g may be formed thin for piercing so that the mixed solution can be extracted by inserting a needle.
  • the seal ring 8 of the middle container 3 may not be provided on the cylindrical outer peripheral surface 3c of the middle container 3 on the side.
  • the seal ring 8 may be provided at the lower end of the middle container 3 and the taper contact surface 6 may be formed on the step portion 5 of the container body 2.
  • the stepped portion 5 may be formed with an enlarged diameter so as to increase the sealing property so that the outer diameter of the lower end of the middle container 3 is in contact with the stepped portion 5.
  • the two-component mixing container according to the present invention is not limited to the diagnostic agent described in the examples. Any two types of liquids and pastes that need to be stored in a separated state and mixed when used or necessary, such as chemicals, cosmetics, foods such as dressings and other seasonings, etc. Can be used. About the A liquid which is a 1st agent, a powder, a granule, etc. can also be used.
  • tablets can be used instead of the first solution, A liquid.
  • a patient drinks water and a foaming agent at the time of an X-ray examination of the stomach.
  • a certain amount of foaming agent is stored in the container body and a certain amount of water is stored in the inner container. it can.
  • the separated two agents can be mixed easily and smoothly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Package Specialized In Special Use (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention porte sur un récipient de mélange de deux agents, lequel récipient comprend un récipient interne inséré de façon amovible dans un corps principal de récipient à partir de la partie d'ouverture du corps principal, le récipient interne comprenant une seconde chambre pour stocker un second agent, et au moins une partie d'ouverture latérale formée sur la face latérale du récipient interne, et le corps principal de récipient comprenant une première chambre qui est fermée par la partie inférieure du récipient interne et qui stocke un premier agent, et une partie de mouvement de deux agents qui relie la première chambre à la seconde chambre lorsque le récipient interne est déplacé vers l'arrière.
PCT/JP2010/065533 2010-09-09 2010-09-09 Récipient de mélange de deux agents WO2012032636A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2011507727A JP4844703B1 (ja) 2010-09-09 2010-09-09 二剤混合容器
PCT/JP2010/065533 WO2012032636A1 (fr) 2010-09-09 2010-09-09 Récipient de mélange de deux agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/065533 WO2012032636A1 (fr) 2010-09-09 2010-09-09 Récipient de mélange de deux agents

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WO2012032636A1 true WO2012032636A1 (fr) 2012-03-15

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JP (1) JP4844703B1 (fr)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111031994A (zh) * 2017-08-25 2020-04-17 Cj医药健康株式会社 医用输液袋

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6658749B2 (ja) * 2015-05-27 2020-03-04 ニプロ株式会社 二剤混合容器
JP6839550B2 (ja) * 2017-01-31 2021-03-10 株式会社吉野工業所 二剤混合容器

Citations (6)

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US3279654A (en) * 1965-02-08 1966-10-18 Richard L Pierick Syringe
JPS62271862A (ja) * 1986-02-03 1987-11-26 シユタイクミユ−レ・テス・アクチエンゲゼルシヤフト １つの容器ユニツト内の少なくとも２つの収納室間に連通口を形成する方法及び容器ユニツト
JP2000085829A (ja) * 1998-09-09 2000-03-28 Dainippon Printing Co Ltd 二液混合容器
US6447476B1 (en) * 1999-11-19 2002-09-10 Dentaco Dentalindustrie-Und Marketing Gmbh Prefilled telescoping ampoule device
JP2008518858A (ja) * 2004-11-04 2008-06-05 ヴィズ エンタープライゼズ，エルエルシー 複室容器及びその蓋
JP2010202237A (ja) * 2009-03-02 2010-09-16 Dic Plastics Inc 二剤混合容器

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3279654A (en) * 1965-02-08 1966-10-18 Richard L Pierick Syringe
JPS62271862A (ja) * 1986-02-03 1987-11-26 シユタイクミユ−レ・テス・アクチエンゲゼルシヤフト １つの容器ユニツト内の少なくとも２つの収納室間に連通口を形成する方法及び容器ユニツト
JP2000085829A (ja) * 1998-09-09 2000-03-28 Dainippon Printing Co Ltd 二液混合容器
US6447476B1 (en) * 1999-11-19 2002-09-10 Dentaco Dentalindustrie-Und Marketing Gmbh Prefilled telescoping ampoule device
JP2008518858A (ja) * 2004-11-04 2008-06-05 ヴィズ エンタープライゼズ，エルエルシー 複室容器及びその蓋
JP2010202237A (ja) * 2009-03-02 2010-09-16 Dic Plastics Inc 二剤混合容器

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111031994A (zh) * 2017-08-25 2020-04-17 Cj医药健康株式会社 医用输液袋

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JP4844703B1 (ja) 2011-12-28

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