WO2012019372A1 - Medicinal healthcare solid electronic cigarette atomizing solution and preparation thereof - Google Patents

Medicinal healthcare solid electronic cigarette atomizing solution and preparation thereof Download PDF

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Publication number
WO2012019372A1
WO2012019372A1 PCT/CN2010/076374 CN2010076374W WO2012019372A1 WO 2012019372 A1 WO2012019372 A1 WO 2012019372A1 CN 2010076374 W CN2010076374 W CN 2010076374W WO 2012019372 A1 WO2012019372 A1 WO 2012019372A1
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extract
solution
solid electronic
atomizing solution
medicinal health
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PCT/CN2010/076374
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French (fr)
Chinese (zh)
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郑胜强
周霞
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深圳市如烟生物科技有限公司
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Publication of WO2012019372A1 publication Critical patent/WO2012019372A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Definitions

  • the invention relates to a medicinal health-care electronic aerosolizing liquid and a preparation method thereof, in particular to a solid medicinal health-care electronic aerosolizing liquid for atomization of electronic cigarettes.
  • the electronic cigarettes use liquid electronic atomized liquid to atomize and generate smoke.
  • the liquid electronic atomized liquid is in the electronic cigarette. It often causes problems such as liquid suction, inconvenient transportation, and rapid aroma evaporation.
  • this liquid contains three kinds of non-nitrogen compounds, nitrogen compounds and inorganic salts.
  • the main components contain monosaccharides and disaccharides.
  • the technical problem to be solved by the present invention is to provide a long-lasting fragrance, convenient storage and transportation, uniform volatilization, and dry throat, itchy throat, irritating cough caused by smoking, chronic pharyngitis and dry mouth and thirst.
  • the symptoms of dry cough, sputum or sputum gelation and hard cough have a therapeutic effect, so that the lung physiotherapy can be carried out anytime and anywhere, avoiding the troublesome medical health-type solid electronic aerosolized liquid that must go to the hospital for registration and prescription.
  • Another object of the present invention is to provide a method for preparing the above-mentioned medicinal health-care solid electronic aerosolizing liquid.
  • Medicinal health-type solid electronic aerosolized liquid mainly comprising the following components by weight percentage: Propylene glycol 35 ⁇ 45%, pharmaceutical 30 ⁇ 35%, deionized water 10 ⁇ 15.0%, tobacco extract 3 ⁇ 3.5%, tobacco flavor 3 ⁇ 3.5%, excipient 2 ⁇ 3.0%, pectin calcium gel 0.2 ⁇ 1.0%, curing agent 0.3 ⁇ 0.8%.
  • the medicament mainly comprises the following components by weight percentage: Gynostemma pentaphyllum extract 25 ⁇ 30%, German chamomile extract 5-10%, casein phosphopeptide 5-10%, dandelion extract 5 ⁇ 8%, Astragalus extract 3 ⁇ 8%, honeysuckle extract 5 ⁇ 6%, Chuanbei extract 3.8 ⁇ 5.8%, chrysanthemum extract 5 ⁇ 5.6%, lily extract 4 ⁇ 5%, wood butterfly extract 4 ⁇ 5%, enzyme 1 ⁇ 1.5% , aspartic acid 0.8 ⁇ 1.5%, coenzyme Q10 1 ⁇ 1.33%, dipotassium glycyrrhizinate 0.8 ⁇ 1%, glycyrrhizic acid monoamine 0.5 ⁇ 0.8%, taurine 0.1 ⁇ 0.38%, hyaluronic acid 0.01 ⁇ 0.09%.
  • the curing agent main component was 35% alginate propylene glycol grease and 65% sodium alginate.
  • the excipient main ingredient was 35% xanthan gum and 65% sodium caseinate.
  • the medicinal health-care solid electronic aerosolizing liquid is prepared as follows: (1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ⁇ 90 ° C until completely dissolved; (2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ⁇ 90 ° C; (3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred; (4) The solution in step (3) is filled and then taken to a -10 ° C ⁇ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
  • the medicinal health-care solid electronic atomizing liquid of the invention is not only convenient to carry and use, but also has no harm of second-hand smoke, so it can be completely used in public places without affecting the health of others; at the same time, the pharmaceutical raw materials are processed through different processes. They are mixed together to form a molecular structure that is intertwined and decomposed by high temperature to form a mist. After passing through the mouth, trachea, bronchi, and lobules, the collagen deposition in the airway wall is reduced, and pulmonary fibrosis is suppressed and relieved. The activity of enzymes in macrophages improves the immune function of the lungs.
  • Medicinal health-type solid electronic atomizing solution the main components are: propylene glycol 40%, pharmaceutical 33.2%, deionized water 15.0%, tobacco leaf extract 3.5%, tobacco flavor 3.5%, excipient 3.0%, stabilizer 1.0%, The curing agent is 0.8%.
  • step (1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ⁇ 90 ° C until completely dissolved; (2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ⁇ 90 ° C; (3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred; (4) The solution in step (3) is filled and then taken to a -10 ° C ⁇ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
  • Medicinal health-type solid electronic atomizing solution the main components are: propylene glycol 45%, pharmaceutical 35%, deionized water 10.0%, tobacco leaf extract 3%, tobacco flavor 3.2%, excipient 3.0%, stabilizer 0.5%, The curing agent is 0.3%.
  • step (1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ⁇ 90 ° C until completely dissolved; (2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ⁇ 90 ° C; (3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred; (4) The solution in step (3) is filled and then taken to a -10 ° C ⁇ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
  • Medicinal health-type solid electronic atomizing solution the main components are: propylene glycol 42%, pharmaceutical 32%, deionized water 15.0%, tobacco leaf extract 3.5%, tobacco flavor 3.5%, excipient 2.5%, stabilizer 1%, The curing agent is 0.5%.
  • step (1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ⁇ 90 ° C until completely dissolved; (2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ⁇ 90 ° C; (3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred; (4) The solution in step (3) is filled and then taken to a -10 ° C ⁇ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.

Abstract

A medicinal healthcare solid electronic cigarette atomizing solution and the preparation thereof. The atomizing solution mainly comprises (by weight percentage): propylene glycol 35-45%, medicament 30-35%, deionized water 10-15.0%, tobacco leaf extract solution 3-3.5%, cigarette essence 3-3.5%, excipient 2-3.0%, calcium pectate gelatin 0.2-1.0%, curing agent 0.3-0.8%. The atomizing solution contains multiple medicinal ingredients for treating lung, sothat the atomizing solution can be used to treat the symptoms of pharyngoxerosis, throat itching, irritable cough, chronic pharyngitis, oral and nasal dryness, dry cough and thirsty, little sputum, viscous sputum and distressed cough which are caused by smoking. Because of the solid state, the stability of the atomizing solution is enhanced in storage and usage, and it is much more convenient and flexible in manufacture and transport, and the fragrance of the atomizing solution is reserved more completely.

Description

药用保健型固体电子烟雾化液及制备方法Medicinal health type solid electronic aerosolized liquid and preparation method thereof
技术领域Technical field
本发明涉及一种药用保健型电子烟雾化液及制备方法，特别涉及固体的药用保健型电子烟雾化液，用于电子烟的雾化。The invention relates to a medicinal health-care electronic aerosolizing liquid and a preparation method thereof, in particular to a solid medicinal health-care electronic aerosolizing liquid for atomization of electronic cigarettes.
背景技术Background technique
目前，市场上出现了很多的香烟替代品，其中以电子香烟最为常见，这种电子香烟用液体电子雾化液来进行雾化、产生烟雾效果，但是，这种液体电子雾化液在电子烟中经常会产生液体倒吸、运输不方便、香气挥发快等问题，并且，这种烟液常含一些非含氮化合物、含氮化合物和无机盐三类，主要成份含有单糖、双糖、淀粉、纡维素、果胶质、树脂、蛋白质、氨基酸、烟碱、芳香油、多酚类等等，其中焦油、酚类、醇类、酸类、醛类等40种物质不利于人的健康，对于一些吸烟引起的咽干、咽痒、刺激性咳嗽，慢性咽炎及口鼻干燥、口渴干咳、少痰或痰液胶粘难咳的烟民来说，目前还没有对这些症状具有治疗作用的电子香烟出现。At present, there are many cigarette substitutes on the market, among which electronic cigarettes are the most common. The electronic cigarettes use liquid electronic atomized liquid to atomize and generate smoke. However, the liquid electronic atomized liquid is in the electronic cigarette. It often causes problems such as liquid suction, inconvenient transportation, and rapid aroma evaporation. Moreover, this liquid contains three kinds of non-nitrogen compounds, nitrogen compounds and inorganic salts. The main components contain monosaccharides and disaccharides. Starch, quercetin, pectin, resin, protein, amino acid, nicotine, aromatic oil, polyphenols, etc., of which 40 substances such as tar, phenols, alcohols, acids, aldehydes are not conducive to human Health, for some smokers caused by dry throat, itchy itch, irritating cough, chronic pharyngitis and dry mouth, dry thirst, cough, sputum or sputum glue, hard to cough, there is no such symptom The therapeutic effect of electronic cigarettes appears.
发明内容Summary of the invention
针对以上问题，本发明要解决的技术问题就是要提供保香持久，存储运输方便，香味挥发均匀，且对吸烟引起的咽干、咽痒、刺激性咳嗽，慢性咽炎及口鼻干燥、口渴干咳、少痰或痰液胶粘难咳的症状具有治疗作用，使得肺部理疗随时随地进行，避免了一定要去医院挂号和处方的麻烦的药用保健型固体电子烟雾化液。In view of the above problems, the technical problem to be solved by the present invention is to provide a long-lasting fragrance, convenient storage and transportation, uniform volatilization, and dry throat, itchy throat, irritating cough caused by smoking, chronic pharyngitis and dry mouth and thirst. The symptoms of dry cough, sputum or sputum gelation and hard cough have a therapeutic effect, so that the lung physiotherapy can be carried out anytime and anywhere, avoiding the troublesome medical health-type solid electronic aerosolized liquid that must go to the hospital for registration and prescription.
本发明的另一目的是提供上述药用保健型固体电子烟雾化液的制备方法。Another object of the present invention is to provide a method for preparing the above-mentioned medicinal health-care solid electronic aerosolizing liquid.
本发明的目的通过下述技术方案予以实现：
药用保健型固体电子烟雾化液，主要包含重量百分比的如下组成：
丙二醇35~45%，药剂30~35%，去离子水10~15.0%，烟叶提取液3~3.5%，烟草香精3~3.5%，赋形剂2~3.0%，果胶酸钙凝胶0.2~1.0%，固化剂0.3~0.8%。The object of the invention is achieved by the following technical solution:
Medicinal health-type solid electronic aerosolized liquid, mainly comprising the following components by weight percentage:
Propylene glycol 35~45%, pharmaceutical 30~35%, deionized water 10~15.0%, tobacco extract 3~3.5%, tobacco flavor 3~3.5%, excipient 2~3.0%, pectin calcium gel 0.2 ~1.0%, curing agent 0.3~0.8%.
所述药剂主要包含重量百分比的如下组成：绞股蓝萃取液25~30%，德国洋甘菊萃取液5~10%，酪蛋白磷酸肽5~10%，蒲公英萃取液5~8%，黄芪萃取液3~8%，金银花萃取液5~6%，川贝萃取液3.8~5.8%，菊花萃取液5~5.6%，百合萃取液4~5%，木蝴蝶萃取液4~5%，酵素1~1.5%，天门冬氨酸0.8~1.5%，辅酶Q10 1~1.33%，甘草酸二钾0.8~1%，甘草酸单胺0.5~0.8%，牛磺酸0.1~0.38%，透明质酸0.01~0.09%。The medicament mainly comprises the following components by weight percentage: Gynostemma pentaphyllum extract 25~30%, German chamomile extract 5-10%, casein phosphopeptide 5-10%, dandelion extract 5~8%, Astragalus extract 3~ 8%, honeysuckle extract 5~6%, Chuanbei extract 3.8~5.8%, chrysanthemum extract 5~5.6%, lily extract 4~5%, wood butterfly extract 4~5%, enzyme 1~1.5% , aspartic acid 0.8~1.5%, coenzyme Q10 1~1.33%, dipotassium glycyrrhizinate 0.8~1%, glycyrrhizic acid monoamine 0.5~0.8%, taurine 0.1~0.38%, hyaluronic acid 0.01~0.09%.
所述固化剂主成成分为35%的藻酸丙二醇脂和65%的海藻酸钠。 The curing agent main component was 35% alginate propylene glycol grease and 65% sodium alginate.
所述赋形剂主成成分为35%的黄原胶和65%的酪蛋白酸钠。The excipient main ingredient was 35% xanthan gum and 65% sodium caseinate.
所述药用保健型固体电子烟雾化液，按如下方法制得：
（1）按配方比例准确称好固化剂，果胶酸钙凝胶，赋形剂加入去离子水中，加热搅拌到85°C~90°C至完全溶解；
（2）将步骤（1）中溶液加入到预先称好的丙二醇，充分搅拌，再升温到85°C~90°C；
（3）将步骤（2）中溶液降温至55°C左右加入烟叶提取液，烟草香精，药剂，搅拌均匀；
（4）将步骤（3）中溶液灌装后拿到-10°C~-20°C冰柜急冻得到固体的电子烟雾化液。The medicinal health-care solid electronic aerosolizing liquid is prepared as follows:
(1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ~ 90 ° C until completely dissolved;
(2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ~ 90 ° C;
(3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred;
(4) The solution in step (3) is filled and then taken to a -10 ° C ~ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
本发明的药用保健型固体电子雾化液不但携带和使用极为方便，并且无二手烟的危害，故在公共场合也完全可以用，不会影响他人健康；同时，药剂原料经过不同的加工工艺混合在一起，形成相互包裹的分子结构，经高温加热分解后形成烟雾状，通过口腔，气管，支气管，肺小叶后，降低气道壁胶原组织沉淀，抑制，缓解肺纤维化，同时能提高肺巨噬细胞内酶的活性，改善肺部免疫功能，因此，人们可在享受呑烟吐雾的同时，又可治疗吸烟引起的咽干、咽痒、刺激性咳嗽，慢性咽炎及口鼻干燥、口渴干咳、少痰或痰液胶粘难咳，还能减少体内自由基，阻断亚硝胺，抑制苯并α芘突变，修复吸烟引起的呼吸道损伤，改变吸烟引起的血液流变性等。The medicinal health-care solid electronic atomizing liquid of the invention is not only convenient to carry and use, but also has no harm of second-hand smoke, so it can be completely used in public places without affecting the health of others; at the same time, the pharmaceutical raw materials are processed through different processes. They are mixed together to form a molecular structure that is intertwined and decomposed by high temperature to form a mist. After passing through the mouth, trachea, bronchi, and lobules, the collagen deposition in the airway wall is reduced, and pulmonary fibrosis is suppressed and relieved. The activity of enzymes in macrophages improves the immune function of the lungs. Therefore, people can enjoy the dry throat, pharyngeal itching, irritating cough, chronic pharyngitis and dry nose and mouth, while enjoying smoking and vomiting. Thirsty dry cough, sputum or sputum glue sticky cough, can also reduce free radicals in the body, block nitrosamines, inhibit benzo-α 芘 mutation, repair respiratory damage caused by smoking, change the blood rheology caused by smoking.
具体实施方式detailed description
下面结合结合实施例对本发明作进一步说明。The invention will be further described below in conjunction with the embodiments.
实施例1Example 1
药用保健型固体电子雾化液，主要组成为：丙二醇40%，药剂33.2%，去离子水15.0%，烟叶提取液3.5%，烟草香精3.5%，赋形剂3.0%，稳定剂1.0%，固化剂0.8%。并按下列步骤进行制备：
（1）按配方比例准确称好固化剂，果胶酸钙凝胶，赋形剂加入去离子水中，加热搅拌到85°C~90°C至完全溶解；
（2）将步骤（1）中溶液加入到预先称好的丙二醇，充分搅拌，再升温到85°C~90°C；
（3）将步骤（2）中溶液降温至55°C左右加入烟叶提取液，烟草香精，药剂，搅拌均匀；
（4）将步骤（3）中溶液灌装后拿到-10°C~-20°C冰柜急冻得到固体的电子烟雾化液。Medicinal health-type solid electronic atomizing solution, the main components are: propylene glycol 40%, pharmaceutical 33.2%, deionized water 15.0%, tobacco leaf extract 3.5%, tobacco flavor 3.5%, excipient 3.0%, stabilizer 1.0%, The curing agent is 0.8%. And follow the steps below to prepare:
(1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ~ 90 ° C until completely dissolved;
(2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ~ 90 ° C;
(3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred;
(4) The solution in step (3) is filled and then taken to a -10 ° C ~ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
实施例2Example 2
药用保健型固体电子雾化液，主要组成为：丙二醇45%，药剂35%，去离子水10.0%，烟叶提取液3%，烟草香精3.2%，赋形剂3.0%，稳定剂0.5%，固化剂0.3%。并按下列步骤进行制备：
（1）按配方比例准确称好固化剂，果胶酸钙凝胶，赋形剂加入去离子水中，加热搅拌到85°C~90°C至完全溶解；
（2）将步骤（1）中溶液加入到预先称好的丙二醇，充分搅拌，再升温到85°C~90°C；
（3）将步骤（2）中溶液降温至55°C左右加入烟叶提取液，烟草香精，药剂，搅拌均匀；
（4）将步骤（3）中溶液灌装后拿到-10°C~-20°C冰柜急冻得到固体的电子烟雾化液。Medicinal health-type solid electronic atomizing solution, the main components are: propylene glycol 45%, pharmaceutical 35%, deionized water 10.0%, tobacco leaf extract 3%, tobacco flavor 3.2%, excipient 3.0%, stabilizer 0.5%, The curing agent is 0.3%. And follow the steps below to prepare:
(1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ~ 90 ° C until completely dissolved;
(2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ~ 90 ° C;
(3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred;
(4) The solution in step (3) is filled and then taken to a -10 ° C ~ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
实施例3Example 3
药用保健型固体电子雾化液，主要组成为：丙二醇42%，药剂32%，去离子水15.0%，烟叶提取液3.5%，烟草香精3.5%，赋形剂2.5%，稳定剂1%，固化剂0.5%。并按下列步骤进行制备：
（1）按配方比例准确称好固化剂，果胶酸钙凝胶，赋形剂加入去离子水中，加热搅拌到85°C~90°C至完全溶解；
（2）将步骤（1）中溶液加入到预先称好的丙二醇，充分搅拌，再升温到85°C~90°C；
（3）将步骤（2）中溶液降温至55°C左右加入烟叶提取液，烟草香精，药剂，搅拌均匀；
（4）将步骤（3）中溶液灌装后拿到-10°C~-20°C冰柜急冻得到固体的电子烟雾化液。Medicinal health-type solid electronic atomizing solution, the main components are: propylene glycol 42%, pharmaceutical 32%, deionized water 15.0%, tobacco leaf extract 3.5%, tobacco flavor 3.5%, excipient 2.5%, stabilizer 1%, The curing agent is 0.5%. And follow the steps below to prepare:
(1) Accurately weigh the curing agent according to the formula ratio, calcium pectate gel, excipients added to deionized water, and heated to 85 ° C ~ 90 ° C until completely dissolved;
(2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ~ 90 ° C;
(3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred;
(4) The solution in step (3) is filled and then taken to a -10 ° C ~ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.

Claims (5)

  1. 药用保健型固体电子烟雾化液，其特征在于主要包含重量百分比的如下组分： Medicinal health-type solid electronic aerosolized liquid characterized by mainly comprising the following components by weight:
    丙二醇35~45%，药剂30~35%，去离子水10~15.0%，烟叶提取液3~3.5%，烟草香精3~3.5%，赋形剂2~3.0%，果胶酸钙凝胶0.2~1.0%，固化剂0.3~0.8%。Propylene glycol 35~45%, pharmaceutical 30~35%, deionized water 10~15.0%, tobacco extract 3~3.5%, tobacco flavor 3~3.5%, excipient 2~3.0%, pectin calcium gel 0.2 ~1.0%, curing agent 0.3~0.8%.
  2. 按权利要求1所述的药用保健型固体电子烟雾化液，其特征在于所述药剂主要包含重量百分比的如下组分：绞股蓝萃取液25~30.0%，德国洋甘菊萃取液5~10.0%，酪蛋白磷酸肽5~10.0%，蒲公英萃取液5~8.0%，黄芪萃取液3~8.0%，金银花萃取液5~6.0%，川贝萃取液3.8~5.8%，菊花萃取液5~5.6%，百合萃取液4~5.0%，木蝴蝶萃取液4~5.0%，酵素1~1.5%，天门冬氨酸0.8~1.5%，辅酶Q10 1~1.33%，甘草酸二钾0.8~1.0%，甘草酸单胺0.5~0.8%，牛磺酸0.1~0.38%，透明质酸0.01~0.09%。The medicinal health-care solid electronic aerosolizing liquid according to claim 1, wherein the medicament mainly comprises the following components in a weight percentage: Gynostemma pentaphyllum extract 25~30.0%, German chamomile extract 5~10.0%, cheese Protein phosphopeptide 5~10.0%, dandelion extract 5~8.0%, astragalus extract 3~8.0%, honeysuckle extract 5~6.0%, Chuanbei extract 3.8~5.8%, chrysanthemum extract 5~5.6%, lily Extract 4~5.0%, wood butterfly extract 4~5.0%, enzyme 1~1.5%, aspartic acid 0.8~1.5%, coenzyme Q10 1~1.33%, dipotassium glycyrrhizinate 0.8~1.0%, glycyrrhizic acid monoamine 0.5~0.8%, taurine 0.1~0.38%, hyaluronic acid 0.01~0.09%.
  3. 按权利要求1所述的药用保健型固体电子烟雾化液，其特征在于所述固化剂主成成分为35%的藻酸丙二醇脂和65%的海藻酸钠。The medicinal health-care solid electronic aerosolizing liquid according to claim 1, wherein said curing agent main component is 35% of alginate glycerol and 65% of sodium alginate.
  4. 按权利要求1所述的药用保健型固体电子烟雾化液，其特征在于所述赋形剂主成成分为35%的黄原胶和65%的酪蛋白酸钠。The medicinal health-care solid electronic aerosolizing liquid according to claim 1, wherein the excipient main component is 35% xanthan gum and 65% sodium caseinate.
  5. 权利要求1所述的药用保健型固体电子烟雾化液的制备方法，其特征在于包括如下步骤： The method for preparing a medicinal health-care solid electronic aerosolized liquid according to claim 1, comprising the steps of:
    （1） 按配方比例准确称好固化剂，果胶酸钙凝胶，赋形剂加入去离子水中，加热搅拌到85°C~90°C至完全溶解；(1) Accurately weigh the curing agent according to the proportion of the formula, calcium pectate gel, excipients added to deionized water, heated to 85 ° C ~ 90 ° C until completely dissolved;
    （2） 将步骤（1）中溶液加入到预先称好的丙二醇，充分搅拌，再升温到85°C~90°C；(2) adding the solution in step (1) to the pre-weighed propylene glycol, stirring well, and then heating to 85 ° C ~ 90 ° C;
    （3） 将步骤（2）中溶液降温至55°C左右加入烟叶提取液，烟草香精，药剂，搅拌均匀；(3) The solution in step (2) is cooled to about 55 ° C to add tobacco extract, tobacco flavor, medicament, and evenly stirred;
    （4） 将步骤（3）中溶液灌装后拿到-10°C~-20°C冰柜急冻得到固体的电子烟雾化液。(4) After filling the solution in step (3), take it to -10 ° C ~ -20 ° C freezer to freeze to obtain a solid electronic aerosolization liquid.
PCT/CN2010/076374 2010-08-09 2010-08-26 Medicinal healthcare solid electronic cigarette atomizing solution and preparation thereof WO2012019372A1 (en)

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