WO2011155425A1 - Préparation cutanée pour usage externe - Google Patents

Préparation cutanée pour usage externe Download PDF

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Publication number
WO2011155425A1
WO2011155425A1 PCT/JP2011/062890 JP2011062890W WO2011155425A1 WO 2011155425 A1 WO2011155425 A1 WO 2011155425A1 JP 2011062890 W JP2011062890 W JP 2011062890W WO 2011155425 A1 WO2011155425 A1 WO 2011155425A1
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Prior art keywords
carbon atoms
fatty acid
component
mass
skin
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PCT/JP2011/062890
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English (en)
Japanese (ja)
Inventor
荒木　秀文
かおり 井上
宮原　令二
木下　耕一
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株式会社資生堂
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Priority to JP2012519363A priority Critical patent/JPWO2011155425A1/ja
Publication of WO2011155425A1 publication Critical patent/WO2011155425A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to a skin external preparation containing a cooling sensation substance. More specifically, the present invention relates to an external preparation for skin that is excellent in a cooling sensation sustaining effect of a cooling sensation substance and excellent in a feeling of use (such as spreading, familiarity, stickiness, freshness, moistness, and no feeling of burden on the skin).
  • Patent Literature 1 discloses a cooling sensation effect improving composition containing a cooling sensation substance and a cationic surfactant, and a hair treatment agent containing the composition, and particularly a quaternary ammonium salt as the cationic surfactant.
  • distearyldimethylammonium chloride is described as being preferable ([0017]).
  • the document 1 has no description or suggestion on the effect of improving the feeling of use (nobrow, familiarity, stickiness, freshness, moistness, lack of feeling on the skin), and is used as a cationic surfactant in the present invention. There is no description or suggestion about the component (b1).
  • Patent Document 2 discloses a refreshing agent comprising a nonionic surfactant having a HLB of 15 or more (for example, decaglyceryl monolaurate).
  • a surfactant with HLB 15 or higher has high hydrophilicity, and therefore, a significant stickiness occurs when it is dried after coating.
  • Patent Document 5 describes a cooling agent composition that is durable and provides a strong cooling effect by combining a cooling substance and vanillyl butyl ether.
  • Patent Document 6 describes a cooling sensation composition that is durable and provides a strong cooling effect by combining a cooling sensation substance with a specific salicylic acid ester.
  • these documents do not have any description or suggestion about the effect of improving the feeling of use (nodding, familiarity, stickiness, freshness, moistness, lack of burden on skin), and description of the component (b2) used in the present invention. ⁇ There is no suggestion.
  • the present invention provides an external preparation for skin that is excellent in a cooling sensation sustaining effect of a cooling sensation substance and that is excellent in use feeling improvement effect (longness, familiarity, stickiness, freshness, moistness, no feeling of burden on the skin). With the goal.
  • the present invention provides (a) a cooling sensation substance in an amount of 0.01 to 1% by mass, (b) (b1) a compound represented by the following formula (I), and / or (b2) Provided is a skin external preparation containing 0.1 to 3% by mass of a 1-acyl lysophospholipid represented by the formula (II) or (III).
  • R 1 CO independently represents an aliphatic acyl group having 12 to 22 carbon atoms and 0 to 3 double bonds; n represents a number of 0 to 3; X Represents a halogen compound, methosulfate or methophosphate. However, when n is 0, the group — (CH 2 ) n —OH is a methyl group.
  • R 2 is a saturated fatty acid residue having 1 to 24 carbon atoms or 18, 20, 22, or 24 carbon atoms and having 1 to 4 unsaturated double bonds.
  • R 3 represents a saturated fatty acid residue having 13 to 24 carbon atoms or a fatty acid residue having 1 to 4 unsaturated double bonds having 18, 20, 22, or 24 carbon atoms.
  • M represents a hydrogen atom or an alkali metal atom.
  • an external preparation for skin is provided that is excellent in a cooling sensation sustaining effect of a cooling sensation substance and that is excellent in use feeling improvement effect (such as stretch, familiarity, stickiness, freshness, moistness, and a feeling of strain on the skin).
  • POE means polyoxyethylene
  • POP means polyoxypropylene
  • POB means polyoxybutylene
  • the cooling sensation substance as the component (a) used in the present invention is not particularly limited as long as it can be generally blended into cosmetics.
  • menthol, camphor, 3-L-menthoxypropane-1,2-diol and the like are preferably used.
  • the amount of component (a) is 0.01 to 1% by mass, preferably 0.1 to 0.5% by mass, and particularly preferably 0.1 to 0.3% by mass in the external preparation for skin of the present invention. It is. If the blending amount is less than 0.01% by mass, a sufficient cooling sensation sustaining effect cannot be achieved. On the other hand, if it exceeds 1% by mass, the use feeling is inferior.
  • Component (b) In this invention, 1 type (s) or 2 or more types chosen from the following (b1) component and (b2) component are used as (b) component.
  • ⁇ (B1) component> a compound represented by the following formula (I) is used as the component (b1).
  • R 1 CO represents an aliphatic acyl group having 12 to 22 carbon atoms and having 0 to 3 double bonds.
  • n represents a number from 0 to 3. Preferably it is 2 or 3.
  • the group — (CH 2 ) n —OH represents a methyl group.
  • X represents a halogen compound, methosulfate or methophosphate. Preferred are halogen compounds or methosulfate, and particularly preferred is methosulfate.
  • a coconut oil fatty acid ester quat halide or methosulphate is preferably used.
  • dicocoylethylhydroxyethylmonium methosulphate is preferable, and the trade name “DEHYQUART L80” (Cognis Japan) etc. Sold.
  • a 1-acyl lysophospholipid represented by the following formula (II) or (III) is used as the component (b2).
  • R 2 represents a saturated fatty acid residue having 1 to 24 carbon atoms or a fatty acid residue having 18 to 20, 24, 24 carbon atoms and 1 to 4 unsaturated double bonds. Preferably, it represents a saturated fatty acid residue having 11 to 18 carbon atoms or a fatty acid residue having 18 to 18 carbon atoms and having 1 to 3 unsaturated double bonds.
  • R 3 represents a saturated fatty acid residue having 13 to 24 carbon atoms or a fatty acid residue having 18 to 20, 24, 24 carbon atoms and 1 to 4 unsaturated double bonds. Preferably, it represents a saturated fatty acid residue having 13 to 18 carbon atoms or a fatty acid residue having 18 to 18 carbon atoms and having 1 to 3 unsaturated double bonds.
  • M represents a hydrogen atom or an alkali metal atom.
  • the component (b2) may be commercially available or can be obtained by treating a commercially available phospholipid with phospholipase A2.
  • 1-acyl lysophospholipid having a constant number of carbon atoms can be obtained by treating the synthesized 1,2-diacyl phospholipid with phospholipase A2.
  • lysophosphatidylcholine obtained by reacting 1 mol or less of fatty acid anhydride or fatty acid halide under a catalyst with respect to 1 mol of glycerophosphocholine can also be obtained having a certain carbon chain (Japanese Patent Application Laid-Open No. Sho-sho). 63-225388).
  • Component (b2) is preferably an acyl group derived from an unsaturated fatty acid when R 2 is a single acyl group, and is unsaturated when R 3 is a single acyl group. It is preferably an acyl group derived from a fatty acid, and when R 3 contains two or more acyl groups derived from natural products, this is preferably a fatty acid residue derived from soybean.
  • phospholipids of the formula (III), wherein R 3 has 18 carbon atoms and a fatty acid residue having three unsaturated double bonds particularly preferred are phospholipids of the formula (III), wherein R 3 has 18 carbon atoms and has a fatty acid residue having 1 to 2 unsaturated double bonds.
  • Component (b2) is a commercially available product, for example, “Ripidur” (manufactured by NOF Corporation. Fatty acid residue having two unsaturated double double bonds in formula (III) where R 3 has 18 carbon atoms.
  • “San lysolecithin” (manufactured by Taiyo Kagaku Co., Ltd.)
  • R 3 has 18 carbon atoms and has two unsaturated double bonds. As a main component).
  • the amount of the component (b) is 0.1 to 3% by mass, preferably 0.1 to 2% by mass, particularly preferably 0.4 to 1.5% by mass in the external preparation for skin of the present invention. . If the blending amount is less than 0.1% by mass, a sufficient cooling sensation sustaining effect cannot be achieved. On the other hand, if it exceeds 3% by mass, the feeling in use is inferior.
  • the component (c) in addition to the components (a) and (b), it is preferable to add (c) ethanol in order to further improve the cooling sensation duration.
  • the component (c) is blended, it is preferably blended in an amount of 3 to 35 mass%, more preferably 5 to 30 mass%, in the external preparation for skin of the present invention.
  • the external preparation for skin of the present invention is within the range not impairing the effects of the present invention, and other optional additive components that are usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as fats and oils, waxes, Hydrocarbon oil, higher fatty acid, higher alcohol, synthetic ester oil, silicone oil, anionic surfactant, cationic surfactant, nonionic surfactant, water-soluble polymer, chelating agent, polyhydric alcohol, pH adjuster, oxidation An inhibitor, a powder component, a fragrance
  • cosmetics and pharmaceuticals such as fats and oils, waxes, Hydrocarbon oil, higher fatty acid, higher alcohol, synthetic ester oil, silicone oil, anionic surfactant, cationic surfactant, nonionic surfactant, water-soluble polymer, chelating agent, polyhydric alcohol, pH adjuster, oxidation
  • oils and fats examples include corn oil, olive oil, rapeseed oil, castor oil, soybean oil, peanut oil, glycerin triisooctanoate, and other solid oils such as cocoa butter and hardened oil.
  • waxes examples include beeswax, carnauba wax, lanolin and the like.
  • hydrocarbon oil examples include oils such as liquid paraffin, squalane, ceresin, petrolatum, paraffin, and microcrystalline wax.
  • higher fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toluic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
  • higher alcohols examples include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol, etc.).
  • linear alcohols eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol
  • branched chain alcohols eg, monostearyl glycerin ether (batyl alcohol)
  • 2-decyltetradecinol lanolin alcohol
  • cholesterol phytosterol
  • hexyl decanol isosteary
  • Synthetic ester oils include isopropyl myristate, octyldodecyl myristate, myristyl myristate, isopropyl palmitate, hexyl laurate, decyl oleate, oleyl oleate, cetyl lactate, isocetyl isostearate, diisopropyl adipate, diethyl sebacate, And diisopropyl sebacate, crotamiton (C 13 H 17 NO), and the like.
  • silicone oil examples include chain polysiloxanes such as dimethylpolysiloxane and methylphenylpolysiloxane.
  • anionic surfactant examples include fatty acid soaps (for example, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (for example, sodium lauryl sulfate, sodium cetyl sulfate); phosphate ester salts (POE-oleyl) Ether sodium phosphate, etc.).
  • fatty acid soaps for example, sodium laurate, sodium palmitate, etc.
  • higher alkyl sulfates for example, sodium lauryl sulfate, sodium cetyl sulfate
  • phosphate ester salts POE-oleyl
  • Examples of the cationic surfactant include benzalkonium chloride.
  • lipophilic nonionic surfactant examples include propylene glycol fatty acid esters (for example, propylene glycol monostearate); hardened castor oil derivatives, and the like.
  • hydrophilic nonionic surfactant examples include POE sorbite fatty acid esters (for example, POE-sorbite monolaurate, POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite monostearate, etc.); POE-glycerin fatty acid esters (for example, POE-glycerin monostearate, POE-glycerin monoisostearate, POE-monooleate such as POE-glycerin triisostearate, etc.); POE-fatty acid esters (eg, POE-distearate) POE-monodiolate, ethylene glycol distearate, etc.); POE-alkyl ethers (eg POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE- Henyl ether, POE-2-octyldodecyl ether, POE-
  • water-soluble polymers examples include plant polymers (eg, carrageenan, pectin, corn starch, etc.); microbial polymers (eg, xanthan gum, pullulan, sodium hyaluronate); and cellulose polymers (methylcellulose, ethylcellulose) , Hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, etc.); alginic acid polymers (eg, sodium alginate); vinyl polymers (eg, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.) It is done.
  • plant polymers eg, carrageenan, pectin, corn starch, etc.
  • microbial polymers eg, xanthan gum, pullulan, sodium hyaluronate
  • cellulose polymers methylcellulose, ethylcellulose
  • Hydroxyethyl cellulose Hydroxyethyl cellulose,
  • chelating agents examples include sodium edetate and sodium metaphosphate.
  • polyhydric alcohols examples include dihydric alcohols (eg, propylene glycol, 1,3-butylene glycol, etc.); trivalent alcohols (eg, glycerin, etc.); tetravalent alcohols (eg, 1,2,6- Pentaerythritol such as hexanetriol); pentahydric alcohol (eg, xylitol, etc.); hexavalent alcohol (eg, sorbitol, mannitol, etc.); polyhydric alcohol polymer (eg, dipropylene glycol, triethylene glycol, polyethylene glycol, etc.) ); Sugar alcohols (for example, sorbitol, mannitol, etc.) and the like.
  • dihydric alcohols eg, propylene glycol, 1,3-butylene glycol, etc.
  • trivalent alcohols eg, glycerin, etc.
  • tetravalent alcohols eg, 1,2,6- Pentaery
  • pH adjuster examples include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate; amino acids (eg, glycine) and the like.
  • antioxidants examples include dibutylhydroxytoluene (BHT) and butylhydroxyanisole (BHA).
  • the powder component examples include inorganic powders (eg, talc, kaolin, bentonite, magnesium aluminate silicate, anhydrous silicic acid, titanium oxide, zinc oxide, etc.); organic powders (eg, cellulose powder); inorganic pigments (eg, , Iron sesquioxide, yellow iron sesquioxide, black iron oxide, etc.); organic pigments (for example, aluminum lake) and the like.
  • inorganic powders eg, talc, kaolin, bentonite, magnesium aluminate silicate, anhydrous silicic acid, titanium oxide, zinc oxide, etc.
  • organic powders eg, cellulose powder
  • inorganic pigments eg, Iron sesquioxide, yellow iron sesquioxide, black iron oxide, etc.
  • organic pigments for example, aluminum lake
  • antiseptics ethyl paraben, butyl paraben, etc.
  • anti-inflammatory agents eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, allantoin, etc.
  • vitamins eg, vitamin B6, Vitamin C, Vitamin E and its derivatives, panthenol, etc.
  • various extracts for example, Izayoi rose, Achillea millefolium, Merilot, Oat, Ouren, Shikon, Peonies, Assembly, Birch, Sage, Loquat, Carrot, Aloe, Xenia mallow, Iris , Grape, yokuinin, loofah, lily, saffron, senkyu, ginger, hypericum, onionis, garlic, pepper, chimpi, red pepper, seaweed, etc.); blood circulation promoter (eg nonyl acid vanillylamide, nic
  • the skin external preparation of the present invention is widely applicable in the fields of cosmetics, pharmaceuticals, and quasi drugs.
  • the dosage form is not particularly limited as long as it can be applied to the skin, and preferred examples include skin lotion, gel, emulsion, cream and the like.
  • Preferred product forms include facial skin cosmetics, body skin cosmetics, lip cosmetics, scalp cosmetics, and the like.
  • the blending amount is expressed in mass% with respect to the system in which the component is blended.
  • test method and evaluation method used in this example will be described.
  • [Usage feeling] 10 panel feels when each sample of each example and comparative example (skin lotion) is applied to the entire face (feeling of nodding, familiarity, stickiness, freshness, moistness, no burden on the skin) Were evaluated (overall evaluation) and evaluated based on the following evaluation criteria.
  • Example 1 Samples (skin lotions) having the compositions shown in Table 1 below were prepared by a conventional method, and the cooling duration and the feeling in use were evaluated according to the above test method and evaluation criteria. The results are shown in Table 1.
  • Table 1 “DEHYQUAT L80” (Cognis Japan) was used as “dicocoylethylhydroxyethylmonium methosulfate (* 1) ”.
  • Example 6 to 10 Comparative Examples 6 to 10.
  • Samples (skin lotions) having the compositions shown in Table 2 below were prepared by a conventional method, and the cooling duration and the feeling in use were evaluated according to the above test method and evaluation criteria. The results are shown in Table 2.
  • “Lipidur” manufactured by NOF Corporation
  • Example 11 lotion
  • Example 11 lotion
  • Menthol 0.1 (13) Camphor 0.05
  • a lotion was obtained by mixing an aqueous phase in which (1) to (9) were uniformly mixed at room temperature and an alcohol phase in which (11) to (13) were uniformly dissolved in (10).
  • Example 12 Latex (Mixed component) (mass%) (1) Ion exchange water Residual (2) Glycerin 5 (3) Butylene glycol 5 (4) Dicocoylethylhydroxyethylmonium methosulfate 0.5 (5) Polyethylene glycol 1500 2 (6) Ethanol 3 (7) Phenoxyethanol 0.3 (8) Paraben 0.1 (9) Potassium hydroxide 0.1 (10) Trisodium edetate 0.05 (11) Carboxyvinyl polymer 0.1 (12) Xanthan gum 0.1 (13) Behenyl alcohol 0.5 (14) Petrolatum 2 (15) Squalane 3 (16) Decamethylcyclopentasiloxane 3 (17) Dimethylpolysiloxane 2 (18) Cetyl 2-ethylhexanoate 2 (19) PEG-60 glyceryl isostearate 1 (20) PEG-5 glyceryl stearate 1 (21) Menthol 0.1 (22) Fragrance 0.1 (Production method) After
  • Example 13 Cream
  • (Mixed component) (mass%) (1) Ion exchange water Residual (2) Glycerin 7 (3) Dipropylene glycol 7 (4) Dicocoylethylhydroxyethylmonium methosulfate 0.2 (5) Erythritol 1 (6) Polyethylene glycol 20000 2 (7) Phenoxyethanol 0.5 (8) Triethanolamine 0.5 (9) edetate trisodium 0.1 (10) Carboxyvinyl polymer 0.1 (11) Xanthan gum 0.1 (12) Behenyl alcohol 3 (13) Stearyl alcohol 1 (14) Microcrystalline wax 1 (15) Petrolatum 2 (16) Squalane 5 (17) Decamethylcyclopentasiloxane 3 (18) Dimethylpolysiloxane 3 (19) Isononyl isononanoate 2 (20) PEG-60 glyceryl isostearate 1 (21) PEG-5 glyceryl stearate 1 (22) Menthol 0.05 (23) Camphor 0.05 (24) Fra
  • Example 14 Sunscreen cosmetics (Mixed component) (mass%) (1) Polyoxyethylene hydrogenated castor oil 1 (2) Dimethicone copolyol 0.5 (3) Decamethylcyclopentasiloxane 15 (4) Behenic acid 0.3 (5) Stearic acid 0.2 (6) Behenyl alcohol 0.3 (7) Phenyltrimethicone 1 (8) Hydrophobized titanium oxide 5 (9) Hydrophobized zinc oxide 2 (10) Spherical polyalkyl acrylate powder 2 (11) 2-ethylhexyl paramethoxycinnamate 5 (12) Menthol 0.1 (13) Citric acid 0.01 (14) Sodium citrate 0.09 (15) Silica 1 (16) Sodium hydroxide 0.05 (17) Ethanol 5 (18) Butylene glycol 2 (19) Dicocoylethylhydroxyethylmonium methosulfate 0.1 (20) Phenoxyethanol 0.5 (21) Succinoglucan 0.2 (22) Cellulose gum 1 (23) Residual solvent
  • Example 16 Skin cleansing agent
  • (Mixed component) (mass%) (1) Purified water Residue (2) Ethanol 15 (3) Sucrose / Sorbit mixture 15 (4) Sorbit solution 10 (5) POP (9) diglyceryl ether 4 (6) Castor oil 2 (7) Isostearic acid 2 (8) Stearic acid 7 (9) Lauric acid 6 (10) Myristic acid 11 (11) Palmitic acid 3 (12) Sodium dodecane-1,2-diol ether ether 3 (13) N-methyl taurine sodium 5 (14) Dicocoylethylhydroxyethylmonium methosulfate 0.1 (15) Sodium hydroxide 4 (16) Sodium chloride 0.5 (17) Dibutylhydroxytoluene 0.1 (18) Hydroxyethanediphosphonic acid tetrasodium (30%) 0.1 (19) edetate trisodium 0.1 (20) Dye 0.5 (21) Fragrance 0.1 (22) Menthol 0.5 (Production method) (1) to
  • Example 17 lotion
  • Example 17 lotion
  • Menthol 0.1 (13) Camphor 0.05
  • a lotion was obtained by mixing an aqueous phase in which (1) to (9) were uniformly mixed at room temperature and an alcohol phase in which (11) to (13) were uniformly dissolved in (10).
  • Example 18 Latex (Mixed component) (mass%) (1) Ion exchange water Residual (2) Glycerin 5 (3) Butylene glycol 5 (4) 1-acyl lysophospholipid 1 (5) Polyethylene glycol 1500 2 (6) Ethanol 3 (7) Phenoxyethanol 0.3 (8) Paraben 0.1 (9) Potassium hydroxide 0.1 (10) Trisodium edetate 0.05 (11) Carboxyvinyl polymer 0.1 (12) Xanthan gum 0.1 (13) Behenyl alcohol 0.5 (14) Petrolatum 2 (15) Squalane 3 (16) Decamethylcyclopentasiloxane 3 (17) Dimethylpolysiloxane 2 (18) Cetyl 2-ethylhexanoate 2 (19) PEG-60 glyceryl isostearate 1 (20) PEG-5 glyceryl stearate 1 (21) Menthol 0.1 (22) Fragrance 0.1 (Production method) After uniformly mixing (1) to (12) heated to 70 ° C
  • Example 19 Cream
  • (Mixed component) (mass%) (1) Ion exchange water Residual (2) Glycerin 7 (3) Dipropylene glycol 7 (4) 1-acyl lysophospholipid 2 (5) Erythritol 1 (6) Polyethylene glycol 20000 2 (7) Phenoxyethanol 0.5 (8) Triethanolamine 0.5 (9) edetate trisodium 0.1 (10) Carboxyvinyl polymer 0.1 (11) Xanthan gum 0.1 (12) Behenyl alcohol 3 (13) Stearyl alcohol 1 (14) Microcrystalline wax 1 (15) Petrolatum 2 (16) Squalane 5 (17) Decamethylcyclopentasiloxane 3 (18) Dimethylpolysiloxane 3 (19) Isononyl isononanoate 2 (20) PEG-60 glyceryl isostearate 1 (21) PEG-5 glyceryl stearate 1 (22) Menthol 0.05 (23) Camphor 0.05 (24) Fragrance 0.1 (Production method) After uniformly mixing
  • Example 20 Sunscreen cosmetics
  • Melad component (mass%)
  • Polyoxyethylene hydrogenated castor oil 1 Dimethicone copolyol 0.5 (3) Decamethylcyclopentasiloxane 15 (4) Behenic acid 0.3 (5) Stearic acid 0.2 (6) Behenyl alcohol 0.3 (7) Phenyltrimethicone 1 (8) Hydrophobized titanium oxide 5 (9) Hydrophobized zinc oxide 2 (10) Spherical polyalkyl acrylate powder 2 (11) 2-ethylhexyl paramethoxycinnamate 5 (12) Menthol 0.1 (13) Citric acid 0.01 (14) Sodium citrate 0.09 (15) Silica 1 (16) Sodium hydroxide 0.05 (17) Ethanol 5 (18) Butylene glycol 2 (19) 1-acyl lysophospholipid 0.3 (20) Phenoxyethanol 0.5 (21) Succinoglucan 0.2 (22) Cellulose gum 1 (23) Ion-exchanged water residue (production method) After uniformly mixing (1)
  • Example 22 Skin cleansing agent
  • (Mixed component) (mass%) (1) Purified water Residue (2) Ethanol 15 (3) Sucrose / Sorbit mixture 15 (4) Sorbit solution 10 (5) POP (9) diglyceryl ether 4 (6) Castor oil 2 (7) Isostearic acid 2 (8) Stearic acid 7 (9) Lauric acid 6 (10) Myristic acid 11 (11) Palmitic acid 3 (12) Sodium dodecane-1,2-diol ether ether 3 (13) N-methyl taurine sodium 5 (14) 1-acyl lysophospholipid 1 (15) Sodium hydroxide 4 (16) Sodium chloride 0.5 (17) Dibutylhydroxytoluene 0.1 (18) Hydroxyethanediphosphonic acid tetrasodium (30%) 0.1 (19) edetate trisodium 0.1 (20) Dye 0.5 (21) Fragrance 0.1 (22) Menthol 0.5 (Production method) (1) to (22) were heated to 70 ° C., mixed sufficiently
  • an external preparation for skin is provided that is excellent in a cooling sensation sustaining effect of a cooling sensation substance and that is excellent in use feeling improvement effect (such as stretch, familiarity, stickiness, freshness, moistness, and a feeling of strain on the skin).

Abstract

L'invention concerne une préparation cutanée pour usage externe qui possède un excellent effet au niveau de l'amélioration de la sensation lors de l'utilisation (étalement, affinité, adhérence, humidité, mouillage, absence de sensation de charge sur la peau) ainsi qu'un excellent effet pour supporter la sensation de froid d'une substance à sensation de froid. La préparation cutanée pour usage externe contient (a) 0,01-1% en masse d'une substance à sensation de froid (par exemple, menthol, camphre, 3-L-menthoxypropane-1,2-diol ou analogue), (b) 0,1-3% en masse de (b1) un tensio-actif cationique particulier (par exemple le dicocoyle éthyl hydroxyéthylmonium méthosulfate ou analogue) et/ou (b2) 1-acyl lysophospholipide. A volonté 3-35% en masse de (c) éthanol peuvent également être combinés.
PCT/JP2011/062890 2010-06-08 2011-06-06 Préparation cutanée pour usage externe WO2011155425A1 (fr)

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WO2013151042A1 (fr) * 2012-04-02 2013-10-10 高砂香料工業株式会社 Inhibiteur de production de mélanine
WO2020044956A1 (fr) * 2018-08-29 2020-03-05 株式会社 資生堂 Produit cosmétique et nettoyant

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JP2001031551A (ja) * 1999-07-15 2001-02-06 Shiseido Co Ltd 肌荒れ防止・改善用皮膚外用剤
JP2003164501A (ja) * 2001-11-30 2003-06-10 Lion Corp 身体ケア用成型体
JP2003183115A (ja) * 2001-12-17 2003-07-03 Shoko Kagaku Kenkyusho:Kk 変温潤滑剤
JP2004161709A (ja) * 2002-11-15 2004-06-10 Pola Chem Ind Inc ムクミ改善用の化粧品キット

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JP2001031551A (ja) * 1999-07-15 2001-02-06 Shiseido Co Ltd 肌荒れ防止・改善用皮膚外用剤
JP2003164501A (ja) * 2001-11-30 2003-06-10 Lion Corp 身体ケア用成型体
JP2003183115A (ja) * 2001-12-17 2003-07-03 Shoko Kagaku Kenkyusho:Kk 変温潤滑剤
JP2004161709A (ja) * 2002-11-15 2004-06-10 Pola Chem Ind Inc ムクミ改善用の化粧品キット

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Publication number Priority date Publication date Assignee Title
WO2013151042A1 (fr) * 2012-04-02 2013-10-10 高砂香料工業株式会社 Inhibiteur de production de mélanine
JP2013213003A (ja) * 2012-04-02 2013-10-17 Takasago Internatl Corp メラニン生成抑制剤
WO2020044956A1 (fr) * 2018-08-29 2020-03-05 株式会社 資生堂 Produit cosmétique et nettoyant
JP2020033297A (ja) * 2018-08-29 2020-03-05 株式会社 資生堂 化粧料および洗浄料
CN112638355A (zh) * 2018-08-29 2021-04-09 株式会社资生堂 化妆品和清洁品
JP7191593B2 (ja) 2018-08-29 2022-12-19 株式会社 資生堂 化粧料および洗浄料

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