WO2011150632A1 - 具有角膜修补功能的隐形眼镜 - Google Patents

具有角膜修补功能的隐形眼镜 Download PDF

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Publication number
WO2011150632A1
WO2011150632A1 PCT/CN2010/078738 CN2010078738W WO2011150632A1 WO 2011150632 A1 WO2011150632 A1 WO 2011150632A1 CN 2010078738 W CN2010078738 W CN 2010078738W WO 2011150632 A1 WO2011150632 A1 WO 2011150632A1
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WO
WIPO (PCT)
Prior art keywords
contact lens
fish scale
wearer
contact
eye
Prior art date
Application number
PCT/CN2010/078738
Other languages
English (en)
French (fr)
Inventor
赖弘基
林峰辉
林建成
林尚明
张毓忠
Original Assignee
柏登生医股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 柏登生医股份有限公司 filed Critical 柏登生医股份有限公司
Priority to DE212010000221U priority Critical patent/DE212010000221U1/de
Priority to GB1223084.3A priority patent/GB2494592B/en
Priority to JP2013600022U priority patent/JP3184023U/ja
Priority to KR2020127000063U priority patent/KR20130004235U/ko
Publication of WO2011150632A1 publication Critical patent/WO2011150632A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/047—Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures

Definitions

  • the present invention relates to contact lenses, and more particularly to contact lenses having a corneal repair function. Background technique
  • contact lenses For the damage of eyesight, myopia is usually worn by wearing glasses or contact lenses to make the eyes visible.
  • contact lenses For frame glasses or contact lenses, contact lenses have many advantages over frame glasses. For example, contact lenses are not obstructed by the frame, and the wearer itself does not feel the extra weight burden, and has no effect on the appearance of the wearer. In addition, soft contact lenses also have the risk of framing the lenses of the spectacles, so contact lenses also provide more convenience for the mover.
  • contact lenses In the case of contact lenses, they can be roughly divided into hard lenses and soft lenses. Hard contact lenses are harder than soft lenses. Traditional materials used for hard lenses mainly include non-oxygenated polymethyl methacrylate (PMMA) and rigid gas permeable (RGP). ).
  • PMMA polymethyl methacrylate
  • RGP rigid gas permeable
  • the advantage of the hard type is that the material itself does not contain water, and the lens itself is less likely to adsorb proteins, deposits, etc., and if dust enters the eye during the wearing process, the wearer can immediately detect discomfort, although uncomfortable, but Prevents cornea from entering the wearer's eyes.
  • Another traditional contact lens is a soft lens, such as silicone hydrogels, polyacrylamide (PAA), polyhydroxyethylmethacrylate (Poly (2-hydroxy ethyl methacrylate) , pHEMA), etc., it has better comfort for the wearer during use, and because it is cheaper, it is the mainstream in today's market.
  • PAA polyacrylamide
  • PAAm polyhydroxyethylmethacrylate
  • pHEMA pHEMA
  • the soft lens itself easily adsorbs residues such as proteins or lipids, and thus has a problem of fixed attachment of proteins when worn.
  • the lens itself is comfortable during the wearing process because the lens is hydrated, so the wearer itself may be unaware of foreign dust or suspended particles, but actually the dust that has entered the eye has caused wearing. Damage to the corneal surface of the eye. Therefore, wearing it for a long time will inevitably cause different degrees of damage to the surface of the eye tissue. If it is not treated in time, it may cause other eye complications, such as corneal damage.
  • the contact lens provided by the utility model is composed of a substrate, wherein the material of the substrate is a hard bone fish scale.
  • the contact lens provided by the utility model comprises at least a layer of fish scale material composed of a hard bone fish scale, and the fish scale material layer formed by the hard bone fish scale is in contact with the surface of the wearer's eye.
  • the utility model provides a contact lens with a corneal repairing function.
  • the contact lens is composed of a substrate composed of at least one piece of hard bone fish scale, which can be made into a contact lens suitable for a patient's diopter, wherein the hard bone fish scale Contains round scales or scales.
  • the contact lens has a diameter of 13 to 20 mm.
  • the contact lens has a center thickness of 0.03 to 0.13 mm.
  • the contact lens has a water content of 20 to 80%.
  • the present invention provides a contact lens comprising a substrate and a layer of fish scale material made of a hard bone fish scale.
  • the substrate can also be in direct contact with the wearer's eye surface.
  • the present invention also provides a contact lens having a corneal repair function, the contact lens comprising a conventional contact lens material (a prior art contact lens material) and a hard bone fish scale material layer; wherein a surface of the fish scale material layer Direct contact with the wearer's eye surface.
  • the contact lens is divided into a central transparent region (mainly corrected visual region) and a peripheral region; wherein the fish scale material layer has a hollow disc shape (doughnut shape), and the fish scale material layer Located in the peripheral region; in addition, the central transparent region (mainly corrected visual field) has a diameter of 3 to 7 mm, and the outer and outer diameter difference of the peripheral region (fish scale material layer) is 6 to 17 mm.
  • one surface of the layer of fish scale material is in direct contact with the surface of the wearer's eye and the other surface is connected to the conventional contact lens material.
  • the contact lens has a water content of 20 to 80%.
  • the thickness of the contact lens is determined according to the diopter of the wearer, and is determined according to the vision correction needs of the wearer.
  • the contact lens of the present invention comprises hard bone fish scales
  • an advantage of the present invention is that it can have the effect of repairing damaged tissue of the eye.
  • This practical new Types of lenses can help repair the damage caused by the surface of the eye tissue.
  • Figure 1 is a schematic structural view of a first embodiment of the present invention
  • Figure 2 is a schematic structural view of a second embodiment of the present invention.
  • 3A and 3B are schematic views showing the structure of another embodiment of the present invention.
  • FIG. 1 is a schematic view showing the structure of a first embodiment of the present invention, a contact lens 1 , which can be provided with a substrate 10 for repairing the damaged tissue of the eye, wherein the substrate 10 is composed of a substrate 10 .
  • the substrate 10 is composed of a substrate 10 .
  • the diameter of the substrate 10 is about 13 to 20 mm, and the center thickness of the substrate 10 is about 0.03 to 0.13 mm. Further, the substrate 10 has a water content of about 20 to 80%. Wherein, the tensile strength of the substrate 10 is 0.5 to 50 MPa, and the hard bone fish scale may be selected from round scales or scales.
  • FIG. 2 is a schematic structural view showing a second embodiment of the present invention.
  • a soft contact lens 2 is provided, wherein the soft contact lens 2 comprises a substrate 21 and a layer of fish scale material 20 made of a hard bone scale.
  • the hard bone fish scale can be selected from round scales or scales.
  • the location of the layer of fish scale material 20 can be designed as desired.
  • the above-described layer of fish scale material 20 is located on the surface of the substrate 21.
  • the material of the substrate 21 is not limited, that is, the substrate 21 can be various contact lenses currently on the market, such as silicone hydrogels, polyacrylamide (PAA), polymethyl. Polyhydroxyethylmethacrylate (Poly (2-hydroxy ethyl methacrylate), pHEMA).
  • the thickness of the fish scale material layer 20 made of the hard bone fish scale is less than 0.03 mm; and the fish scale material layer 20 made of the hard bone fish scale is limited to not more than one third of the thickness of the conventional contact lens.
  • the thickness of the contact lens is 0.04 mm
  • the thickness of the substrate 21 is greater than 0.03 mm, and the thickness of the fish scale material layer 20 is less than 0.01 mm; if the thickness of the contact lens is 0.12 mm, the utility model is The thickness of the substrate 21 is greater than 0.09 mm, and the thickness of the scale material layer 20 is less than 0.03 mm.
  • a surface of the scale material layer 20 is in direct contact with the wearer's eye surface.
  • the substrate 21 can also be in direct contact with the wearer's eye surface.
  • the portion which can be in direct contact with the wearer's eye surface is not limited to the above-described fish scale material layer 20 and the substrate 21. That is, the portion in direct contact with the wearer's eye surface contains at least a layer 20 of scale material.
  • the contact lens can be prepared by selecting an appropriate fish species, such as selecting a fish species whose fish scale itself is relatively transparent, or by appropriately treating the fish scale, such as a decalcification step (also That is, in one embodiment, the fish scale material applied to the contact lens is a product that has been treated at least by chemical desulfurization or the like, or the combination of the two methods described above to obtain transparency suitable as a result of the contact lens material.
  • the contact lens 3 provided by the present invention comprises a central transparent area 31 and a peripheral area 30 .
  • the central transparent area 31 is a main corrected vision area, and the area is made of a conventional contact lens material 31a, and the peripheral area 30 is made of a hollow disc-shaped (doughnut shape) fish scale material made of hard bone fish scales.
  • the layer 30a has a function of repairing the damaged area of the eye tissue, please refer to FIG. 3A. That is, the contact lens material 31a and the scale material layer 30a are simultaneously in direct contact with the wearer's eye surface.
  • the hollow disc-shaped (doughnut-shaped) scale material layer 30b of the bony scale can be attached to a conventional contact lens material 31b, that is, not in direct contact with the wearer's eye.
  • the material of the material is the same as that used in the central transparent area (mainly corrected visual field), and only the peripheral area that is in direct contact with the wearer's eyes is made up of fish scales, and the hard bone fish scale can directly contact the surface of the eye. That is, one surface of the scale material layer 30b is in direct contact with the wearer's eye surface and the other surface is attached to the conventional contact lens material, see Figure 3B.
  • the fish scale material layer 30b of the present invention is located in the peripheral region 30, wherein the scale material layer 30b has a maximum range equal to the peripheral region 30, and of course, the fish scale material layer 30b may be smaller than the peripheral region 30; and the central transparent region 31 has a diameter of about 3 ⁇ 7 mm, that is, the difference in inner and outer diameters of the peripheral region 30 is about 6 to 17 mm, wherein the so-called inner and outer diameter difference means that the outer diameter of the peripheral region (doughnut-shaped material) is deducted from the inner diameter.
  • the thickness of the scale material layer from the edge of the central transparent region 31 to the edge of the peripheral region 30 can be determined according to the thickness of the wearer, the depth of the wearer and the degree of flash.
  • the conventional contact lens material 31b and the scale material layer 30b are in direct contact with the wearer's eye surface.
  • the portion which can be in direct contact with the wearer's eye surface is not limited to the above-described conventional contact lens material 31b and fish scale material layer 30b. That is, the portion in direct contact with the wearer's eye surface contains at least the fish scale material layer 30b.
  • the various contact lens embodiments of the present invention are all in contact with the wearer's eyes by using different proportions of hard bone fish scales in conventional contact lenses.
  • the main component of the hard bone fish scale is collagen
  • collagen helps to repair damaged eye tissue, that is, the hard bone fish scale is in direct contact with the wearer's eye tissue surface, which is contained in the hard bone fish scale.
  • Some collagen can repair the damaged tissue caused by wearing contact lenses on the cornea surface of the eye, thereby improving the damage caused by the traditional contact lens on the surface of the eye tissue.
  • a contact lens is used to manufacture a contact lens, which is a case where a conventional polymer contact lens material has been crosslinked (polymerized) before molding, that is, a monomer is added first ( Monomer;) a polymer solution that has been previously polymerized, then injected into a mold, and then the fish scale is added to a mold containing a polymer solution before the polymer solution is uncured, and then The mold and the hot air plasticization process, and finally the mold release and hydration to obtain a contact lens with corneal repair.
  • a contact lens is used to manufacture a contact lens, which is a case where a conventional polymer contact lens material has been crosslinked (polymerized) before molding, that is, a monomer is added first ( Monomer;) a polymer solution that has been previously polymerized, then injected into a mold, and then the fish scale is added to a mold containing a polymer solution before the polymer solution is uncured, and then The mold and the hot air plasticization process, and finally
  • the contact lens is produced by the same molding method, it can be produced by using one of the following embodiments, that is, first Forming a polymer-like monomer in a mold, followed by crosslinking (polymerization), then adding a fish scale before the polymer is uncured, and then performing a compression molding operation, followed by hot air molding. Finally, the mold release and hydration steps are carried out to obtain a contact lens with corneal repair.
  • the fish scale is placed in the mold and the fluid monomer is crosslinked (polymerized) into a polymer.
  • the fish scale may be first added to the fluid. After the inside of the mold of the monomer (monomer;), a cross-linking (polymerization) of a monomer in a fluid state is further carried out.
  • the contact lens preparation method can also utilize the rotary casting method, that is, the fluid-like monomer which is a polymer of the contact lens is added to the rotating disk, and then the fish scale is added to the inclusion.
  • the rotating disk of the fluid monomer (monomer;) is then subjected to a rotational molding process.
  • the monomer in the form of a fluid starts to polymerize into a polymer and solidifies, and with the rotation speed
  • it can produce contact lenses suitable for different wearers' needs, and the scales will be fixed in the polymer with the curing process of the polymer, and finally the demoulding and hydration steps will be carried out.
  • Contact lenses with corneal repair are available.
  • the contact lens preparation method can also utilize the cutting method, however
  • a suitable method for making a contact lens by the cutting method is to directly use the fish scale as a material of the contact lens, that is, the case of the first embodiment of the present invention.
  • the process of cutting a known contact lens directly into a whole piece of fish scales; the above-mentioned whole fish scale may include pre-pressing several fish scales into a whole scale to facilitate cutting, but it is not limited thereto.
  • the pressing method may be a frozen compressed deposit manufacturing (FCDM) or a heated compressed deposit manufacturing (HCDM), but other methods may be used to achieve the same. The purpose of suppression.
  • a mixing process that is, a combination of the above methods, can also be used.
  • one advantage of the present invention is that in the process of preparing a contact lens with corneal repair, it is not necessary to deliberately for this purpose. Tailor-made special crafts or instruments, only need to add a certain amount of thickness and size of fish scales in a certain process in the traditional process. In other words, another advantage of the present invention is that it is relatively simple to prepare a contact lens with a repaired cornea.
  • the fish scale material is a natural biomedical material, the preparation process is simple, and the treatment conditions are easy to control.
  • the main component of the fish scale material is collagen, which can repair the cornea.
  • contact lenses can be selected to produce contact lenses.

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Description

具有角膜修补功能的隐形眼镜 技术领域
本实用新型是关于隐形眼镜， 特别是关于具有角膜修补功能的隐形眼 镜。 背景技术
长久以来， 眼睛视力的受损和退化困扰着人们。 一般人常患的近视、 远视、 散光等光线折射异常的视力障碍， 主要由于眼睛长期使用不当、 过 度疲劳及压力等因素所造成， 导致控制视线折射最重要的两条肌肉一一睫 状肌及放射肌的收缩异常和血液循环不良， 因而僵硬变形失去功能， 致使 影像焦点无法正确落在视网膜上。
而对于眼睛视力的受损， 一般近视者会通过配戴有度数的框架眼镜或 是隐形眼镜， 以使眼睛能够看得清楚。 而对于框架眼镜或是隐形眼镜的比 较， 隐形眼镜比框架眼镜具有不少优点， 比如隐形眼镜并没有镜框的阻碍， 配戴者本身不觉多余重量负担， 对配戴者的外观也无影响。 此外， 软式隐 形眼镜也无框架眼镜的镜片可能碎裂的风险， 所以， 隐形眼镜也因此为运 动人士带来更多的方便性。
就隐形眼镜而言， 可大略分为硬式镜片与软式镜片。 硬式隐形镜片比 软式镜片材质较硬， 传统用于硬式镜片的材料主要包含有非透氧的聚甲基 丙烯酸甲酯 （polymethyl methacrylate, PMMA)及硬式高透氧隐形眼镜 (rigid gas permeable, RGP)。
硬式的优点在于材质本身不含水， 镜片本身也较不易吸附蛋白质、 沉 积物等物质， 且若于配戴过程中有灰尘进入眼睛时， 配戴者也能立即察觉 不适， 虽然不舒服， 但却可防止灰尘进入配戴者眼中所造成的角膜伤害。
不过， 硬式隐形眼镜在使用上依旧有诸多限制， 比如激烈运动时尽可 能不要配戴硬式隐形眼镜， 以免硬式镜片于眼睛中破损而导致配戴者视力 受损。
传统的另一种隐形眼镜为软式镜片， 比如硅水凝胶 (silicone hydrogels), 聚 丙 烯 酰胺 （polyacrylamide, PAA) 、 聚 甲 基 丙 烯 酸羟 乙 酯 (polyhydroxyethylmethacrylate, (Poly (2 -hydroxy ethyl methacrylate), pHEMA) 等， 其对配戴者于使用过程中有较佳的舒适感， 并且由于售价较为便宜， 因此是现今市场的主流。
然而， 软式镜片本身容易吸附蛋白质或脂质等残余物， 因而有配戴时 的蛋白质固定附着问题。 此外， 倘若有灰尘进入配戴者眼中时， 由于镜片 含水而在配戴过程感到舒适， 所以佩戴者本身对于外来灰尘或悬浮粒子可 能毫无知觉， 但实际上这些进入眼中的灰尘已造成配戴者眼睛角膜表面的 伤害。 因此， 长时间的配戴下， 必然会对眼组织表面造成程度不一的伤害， 倘若没能及时处理可能引发其它眼睛并发症， 比如角膜损伤。
综上， 不论隐形眼镜材质为何， 不论配戴时间长短， 或多或少都会在 眼组织的表面造成程度不一的伤害， 即便是隐形眼镜的材质日新月异， 仍 旧避免不了这一问题。
因此， 如何能够改善目前隐形眼镜结构与材料的问题， 以使隐形眼镜 能够具有角膜修补功能， 希望能够藉此改善配戴隐形眼镜者的生活质量及 眼睛健康， 是相关业者致力解决的目标。 实用新型内容
本实用新型的目的是提供一种隐形眼镜， 特别是一种具有角膜修补功 能的隐形眼镜。
本实用新型的另一个目的是提供一种可取代现有技术的隐形眼镜。 本实用新型提供的一种隐形眼镜为一底材构成， 其中底材的材料为硬 骨鱼鳞。 本实用新型提供的一种隐形眼镜为至少包含由一硬骨鱼鳞所构成的鱼 鳞材料层， 且该硬骨鱼鳞构成的鱼鳞材料层与配戴者眼睛表面接触。
本实用新型提供了一种具有角膜修补功能的隐形眼镜， 该隐形眼镜由 一底材所构成， 该底材由至少一片硬骨鱼鳞所组成， 可制成适合患者屈光 度的隐形眼镜， 其中该硬骨鱼鳞包含圆鳞或栉鳞。
根据本实用新型， 该隐形眼镜的直径为 13〜20 mm。
根据本实用新型， 该隐形眼镜中心厚度为 0.03〜0.13 mm。
根据本实用新型， 该隐形眼镜含水量为 20〜80%。
本实用新型提供的一种隐形眼镜， 包含一底材与一硬骨鱼鳞制作的一 鱼鳞材料层。 除了鱼鳞材料层与配戴者眼睛表面直接接触外， 底材也可与 配戴者眼睛表面直接接触。
本实用新型还提供了一种具有角膜修补功能的隐形眼镜， 该隐形眼镜 包含一传统的隐形眼镜材料 （现有技术的隐形眼镜材料） 与一硬骨鱼鳞材 料层； 其中该鱼鳞材料层的一表面与配戴者眼睛表面直接接触。
根据本实用新型，该隐形眼镜分为一中心透明区域（主要矫正视力区）， 与一外围区域； 其中所述鱼鳞材料层形状为中空圆盘状 （甜甜圈形状） ， 且该鱼鳞材料层位于所述外围区域； 此外， 所述中心透明区域 （主要矫正 视力区） 的直径为 3〜7 mm, 而该外围区域 （鱼鳞材料层） 的内外直径差 的大小为 6〜17 mm。
根据本实用新型， 所述鱼鳞材料层的一表面与配戴者眼睛表面直接接 触， 另一表面与所述传统的隐形眼镜材料相连。
根据本实用新型， 该隐形眼镜含水量为 20〜80%。
根据本实用新型， 该隐形眼镜的厚度依据配戴者的屈光度不同， 依照 配戴者的视力矫正需求决定。
本实用新型的技术效果： 由于本实用新型的隐形眼镜包含硬骨鱼鳞， 因此本实用新型的一项优点为可具备修补眼睛受损组织的效果。 本实用新 型的眼镜可协助修补眼组织的表面造成的伤害。 关于本实用新型所述的隐形眼镜， 可以藉由以下详述及所附附图得到 进一歩的了解。 附图说明
图 1为本实用新型第一实施例的结构示意图；
图 2为本实用新型第二实施例的结构示意图；
图 3A、 图 3B为本实用新型其他实施例的结构示意图
图中主要符号说明：
1隐形眼镜 10底材
2隐形眼镜 20鱼鳞材料层
21底材 3隐形眼镜
30外围区域 31中心透明区域
30a鱼鳞材料层 31a传统的隐形眼镜材料
30b鱼鳞材料层 31b传统的隐形眼镜材料 具体实施方式
请参照图 1， 此图为显示本实用新型第一实施例的结构示意图， 一种隐 形眼镜 1，该可具备修补眼睛受损组织效果的隐形眼镜 1为一底材 10构成， 其中底材 10为硬骨鱼鳞。
在本实用新型的第一实施例中， 底材 10的直径约为 13〜20 mm， 而底 材 10中心厚度约为 0.03〜0.13 mm。 此外， 底材 10含水量约为 20〜80%。 其中， 底材 10拉伸强度为 0.5〜50 MPa, 而所述的硬骨鱼鳞可选自圆鳞或 栉鳞。
另外， 请参照图 2， 此图为显示本实用新型第二实施例的结构示意图， 提供了一种软式隐形眼镜 2， 其中软式隐形眼镜 2包含一底材 21与一硬骨 鱼鳞制作的鱼鳞材料层 20。 其中， 硬骨鱼鳞可选自圆鳞或栉鳞。
在一较佳实施例中， 鱼鳞材料层 20的位置可根据需要来设计。 举例来 说，上述的鱼鳞材料层 20是位于底材 21表面。此时，底材 21的材料不限， 也就是说底材 21 可为目前市面上贩卖的各种隐形眼镜， 例如硅水凝胶 (silicone hydrogels) 聚丙烯酰胺 (polyacrylamide, PAA)、 聚甲基丙烯酸羟乙 酉旨 (polyhydroxyethylmethacrylate, (Poly (2 -hydroxy ethyl methacrylate), pHEMA)等。
本实用新型的第二实施例中， 以硬骨鱼鳞制作的鱼鳞材料层 20的厚度 小于 0.03 mm; 并且， 以硬骨鱼鳞制作的鱼鳞材料层 20以不超过传统隐形 眼镜厚度的三分之一为限。举例来说， 若隐形眼镜厚度为 0.04 mm, 则在本 实用新型中，底材 21厚度大于 0.03 mm,而鱼鳞材料层 20厚度小于 0.01 mm; 若隐形眼镜厚度为 0.12 mm,则在本实用新型中，底材 21厚度大于 0.09 mm, 而鱼鳞材料层 20厚度小于 0.03 mm。且鱼鳞材料层 20的一表面与配戴者眼 睛表面直接接触。 除了鱼鳞材料层 20与配戴者眼睛表面直接接触外， 底材 21 (传统的隐形眼镜材料， 即现有技术中的隐形眼镜材料） 也可与配戴者 眼睛表面直接接触。 并且可与配戴者眼睛表面直接接触的部分不限于上述 鱼鳞材料层 20以及底材 21。也就是说与配戴者眼睛表面直接接触的部分至 少包含鱼鳞材料层 20。
当然， 关于鱼鳞本身透明度的问题， 则可通过选择适当的鱼种， 如挑 选鱼鳞本身较透明的鱼种来制备此隐形眼镜， 或是将鱼鳞经适当歩骤处理， 比如脱钙歩骤 （亦即在一实施例中， 运用于隐形眼镜的鱼鳞材料为至少经 过脱钙等化学歩骤处理过的产物） 或是合并前述两种方式来得到透明度适 合作为隐形眼镜材质的结果。
但上述的问题亦可通过下列几个实施例来解决。请参照图 3A及图 3B, 本实用新型提供的隐形眼镜 3包含一中心透明区域 31以及一外围区域 30。 其中， 中心透明区域 31为主要矫正视力区域， 且此区域的材质为传统的隐 形眼镜材料 31a，而外围区域 30的材质为由硬骨鱼鳞制成的中空圆盘状（甜 甜圈形状） 鱼鳞材料层 30a， 具有修补眼组织受损区域的功能， 请参照图 3A。 也就是说隐形眼镜材料 31a和鱼鳞材料层 30a同时与配戴者眼睛表面 直接接触。
而在另一实施例中， 该硬骨鱼鳞制成的中空圆盘状 （甜甜圈形状） 鱼 鳞材料层 30b可附着于一传统的隐形眼镜材料 31b上， 亦即未和配戴者眼 睛直接接触的材料的材质与中心透明区域 （主要矫正视力区） 所使用的材 质相同， 而仅在与配戴者眼睛直接接触的外围区域部分为鱼鳞所构成， 并 且使得硬骨鱼鳞可直接与眼睛表面接触， 亦即， 鱼鳞材料层 30b 的一表面 与配戴者眼睛表面直接接触， 另一表面与该传统的隐形眼镜材料相连， 请 参照图 3B。 此外， 本实用新型的鱼鳞材料层 30b位于外围区域 30中， 其 中鱼鳞材料层 30b范围最大与外围区域 30大小相等， 当然鱼鳞材料层 30b 可小于外围区域 30; 其中心透明区域 31直径约为 3〜7 mm, 也就是说外围 区域 30的内外直径差约为 6〜17mm，其中所谓的内外直径差指的是该外围 区域 （甜甜圈形状材料） 的外直径扣掉内直径的大小。 除此之外， 上述的 中心透明区域 31 的边缘到外围区域 30的边缘的鱼鳞材料层厚度可根据需 要有不同的厚度， 端视配戴者的近视深度以及闪光度数来决定。 也就是说 传统的隐形眼镜材料 31b和鱼鳞材料层 30b同时与配戴者眼睛表面直接接 触。 并且可与配戴者眼睛表面直接接触的部分不限于上述传统的隐形眼镜 材料 31b和鱼鳞材料层 30b。亦即， 与配戴者眼睛表面直接接触的部分至少 包含鱼鳞材料层 30b。
本实用新型上述各种隐形眼镜实施例， 皆是藉由利用加入不同比例的 硬骨鱼鳞于传统隐形眼镜中， 使硬骨鱼鳞与配戴者的眼睛接触。 因为硬骨 鱼鳞中的主要成分为胶原蛋白， 胶原蛋白有利于协助修补受损的眼组织， 也就是使硬骨鱼鳞与配戴者的眼组织表面直接接触， 利用硬骨鱼鳞中所含 有的胶原蛋白， 使眼睛的角膜表面因配戴隐形眼镜而造成的损伤组织能够 得到修补， 从而改善传统隐形眼镜在眼组织的表面造成伤害的问题。
而本案的隐形眼镜可藉由至少下列几种方式制得。 首先， 在一实施例 中， 是使用铸模成型法来制造隐形眼镜， 这是针对传统的高分子 (polymer) 隐形眼镜材质于铸模前已交联（聚合）的情况，也就是先加入单体 (monomer;) 已预先聚合成的高分子 (polymer)溶液， 接着注入模具中， 然后在高分子 (polymer)溶液未固化前将鱼鳞加入已装有高分子 (polymer)溶液的模具中， 接着再进行压模以及热风塑化等歩骤， 最后脱模及水合而得到具有角膜修 补的隐形眼镜。
另外， 对于传统的高分子 (polymer)隐形眼镜材质于铸模后再交联 （聚 合） 的情况， 若同样利用铸模成型法制作隐形眼镜时， 则可利用以下之一 实施例来制作， 即先加入形成高分子 (polymer)的呈流体状的单体 (monomer) 于模具中， 接着进行交联（聚合）， 然后在高分子 (polymer)未固化前加入鱼 鳞， 再进行压模动作， 接着热风塑化， 最后再进行脱模及水合等歩骤而得 到具有角膜修补的隐形眼镜。 其中于另一实施例中， 鱼鳞置入模具当中以 及呈流体状的单体 (monomer)进行交联 (聚合) 成高分子 (polymer)的歩骤， 也可选择先加入鱼鳞于装有呈流体状的单体 (monomer;)的模具内后， 再进行 呈流体状的单体 (monomer)的交联 （聚合） 歩骤。
当然， 隐形眼镜制备方法也可利用旋转浇注法， 也就是说先于旋转盘 上加入制成隐形眼镜的高分子 (polymer)的呈流体状的单体 (monomer), 然后 再加入鱼鳞于含有呈流体状的单体 (monomer;)的旋转盘上， 接着进行旋转成 型歩骤， 此时， 呈流体状的单体 (monomer)即开始聚合成高分子 (polymer)并 固化， 并且随着转速的不同， 可产生适合不同配戴者需求的隐形眼镜， 而 鱼鳞亦将随着高分子 (polymer)的固化过程而被固定于高分子 (polymer)中， 最后再进行脱模及水合等歩骤， 而可得到具有角膜修补的隐形眼镜。
除此之外， 在一实施例中， 隐形眼镜制备方法也可利用切削法， 然而 在此实施例中， 切削法比较合适的制作隐形眼镜方法为直接利用鱼鳞作为 隐形眼镜的材质， 也就是本案的第一实施例情况的作法。 歩骤为直接以整 块的鱼鳞进行已知传统隐形眼镜的切削工艺技术； 前述的整块的鱼鳞可包 含先将数片鱼鳞预先压制成一整块鱼鳞以方便切削， 但仍不以此为限， 其 中压制方法可为冷冻挤压层积成型法 ( frozen compressed deposit manufacturing, FCDM)或力口热挤压层禾只成型法 (heated compressed deposit manufacturing, HCDM)， 但亦可用其它方法来达到此一压制目的。
除了上述的各种制造方式之外， 也可利用混合工艺法， 也就是结合上 述各方法来进行制作。
以上所描述的各种制作隐形眼镜方式皆为已知制造隐形眼镜的方法， 也就是说， 本实用新型的一个优点在于制备一具有角膜修补的隐形眼镜的 过程中， 并不需要刻意为此目的而量身打造特殊工艺或器械装置， 仅需于 传统工艺中的某一歩中加入适量厚度及大小的鱼鳞即可。 换句话说， 本实 用新型的另一项优点为制备具有修补角膜的隐形眼镜方法相当简便。
本实用新型的优点至少包括以下几点：
1. 鱼鳞可取得简便， 且来源较不受限制。
2. 鱼与人类至目前为止没有任何互通的疾病， 因此鱼鳞的使用上相当 安全。
3. 鱼鳞材料为天然性的生医材料， 其制备流程简便， 且处理条件较易 掌控。
4. 鱼鳞材料的主要成分为胶原蛋白， 可具备修补眼角膜的效果。
5. 鱼鳞本身的机械强度足够，亦可单纯只以鱼鳞为材料做成隐形眼镜。
6. 通过鱼种的选择， 能挑选鱼鳞本身较透明的鱼种来制得隐形眼镜。
7. 藉由本实用新型的隐形眼镜， 有助于维持隐形眼镜配戴族群的眼睛 健康。
8. 制作本实用新型的具备修补眼睛受损组织的隐形眼镜并不需要特别 的方法， 可结合传统隐形眼镜的工艺。
本实用新型虽以较佳实例阐明如上， 然其并非用以限定本实用新型的 精神与新型实体仅止于上述实施例。 在不脱离本实用新型的精神与范围内 所作的修改， 均应包括在本实用新型的请求保护范围内。

Claims

权利要求书
1. 一种具有角膜修补功能的隐形眼镜， 其特征在于， 该隐形眼镜由一 底材所构成， 该底材由至少一片硬骨鱼鳞所组成， 其中该硬骨鱼鳞包含圆 鳞或栉鳞。
2. 如权利要求 1所述的隐形眼镜， 其特征在于， 该隐形眼镜的直径为 13〜20 mm。
3. 如权利要求 1所述的隐形眼镜， 其特征在于， 该隐形眼镜中心厚度 为 0.03〜0.13 mm。
4. 如权利要求 1所述的隐形眼镜， 其特征在于， 该隐形眼镜含水量为 20〜80%。
5. 一种具有角膜修补功能的隐形眼镜， 其特征在于， 该隐形眼镜包含 一传统的隐形眼镜材料与一硬骨鱼鳞材料层； 其中该鱼鳞材料层的一表面 与配戴者眼睛表面直接接触。
6. 如权利要求 5所述的隐形眼镜， 其特征在于， 该隐形眼镜分为一中 心透明区域与一外围区域； 其中所述鱼鳞材料层形状为中空圆盘状， 且 该鱼鳞材料层位于所述外围区域； 此外， 所述中心透明区域的直径为 3〜 7 mm, 而所述外围区域的内外直径差的大小为 6〜17 mm。
7. 如权利要求 5所述的隐形眼镜， 其特征在于， 所述鱼鳞材料层的一 表面与配戴者眼睛表面直接接触， 另一表面与所述传统的隐形眼镜材料相 连。
8. 如权利要求 5所述的隐形眼镜， 其特征在于， 该隐形眼镜含水量为 20〜80%。
9. 如权利要求 5所述的隐形眼镜， 其特征在于， 该隐形眼镜的厚度依 据配戴者的屈光度不同， 依照配戴者的视力矫正需求决定。
PCT/CN2010/078738 2010-06-04 2010-11-15 具有角膜修补功能的隐形眼镜 WO2011150632A1 (zh)

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