WO2011132990A3 - Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법 - Google Patents

Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법 Download PDF

Info

Publication number
WO2011132990A3
WO2011132990A3 PCT/KR2011/002944 KR2011002944W WO2011132990A3 WO 2011132990 A3 WO2011132990 A3 WO 2011132990A3 KR 2011002944 W KR2011002944 W KR 2011002944W WO 2011132990 A3 WO2011132990 A3 WO 2011132990A3
Authority
WO
WIPO (PCT)
Prior art keywords
pepck
overexpressing
canine
production method
transgenic cloned
Prior art date
Application number
PCT/KR2011/002944
Other languages
English (en)
French (fr)
Other versions
WO2011132990A2 (ko
Inventor
황우석
Original Assignee
Hwang Woo-Suk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hwang Woo-Suk filed Critical Hwang Woo-Suk
Publication of WO2011132990A2 publication Critical patent/WO2011132990A2/ko
Publication of WO2011132990A3 publication Critical patent/WO2011132990A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 PEPCK (Phosphoenol Pyruvate Carboxykinase)를 과발현하는 형질전환 복제 개과 동물 및 이의 생산방법에 관한 것이다. 보다 구체적으로 본 발명은 PEPCK 유전자로 형질전환된 개과 동물 유래 체세포 핵을 탈핵된 난자에 이식하여 형성된 개과 동물의 핵 이식란과 이의 생산방법 및 상기 핵 이식란을 대리모의 난관에 이식하여 생산된 PEPCK를 과발현하는 형질전환 복제 개과 동물 및 이의 생산방법에 관한 것이다. 본 발명에 따른 PEPCK 유전자를 과발현하는 형질전환 복제 개과 동물은 당뇨병 동물 모델로서, 제2형 당뇨병의 유전적 원인 규명과 진단 시약 및 치료제 개발에 이용될 수 있다.
PCT/KR2011/002944 2010-04-22 2011-04-22 Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법 WO2011132990A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100037299A KR20110117841A (ko) 2010-04-22 2010-04-22 Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법
KR10-2010-0037299 2010-04-22

Publications (2)

Publication Number Publication Date
WO2011132990A2 WO2011132990A2 (ko) 2011-10-27
WO2011132990A3 true WO2011132990A3 (ko) 2012-03-08

Family

ID=44834689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/002944 WO2011132990A2 (ko) 2010-04-22 2011-04-22 Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법

Country Status (2)

Country Link
KR (1) KR20110117841A (ko)
WO (1) WO2011132990A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023024125A2 (pt) * 2021-05-21 2024-01-30 Daewoong Pharmaceutical Co Ltd Uso de uma composição farmacêutica

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100733012B1 (ko) * 2005-07-26 2007-06-28 재단법인서울대학교산학협력재단 복제된 개과 동물 및 이의 생산 방법
KR20090115025A (ko) * 2008-04-30 2009-11-04 황우석 개과 동물의 복제 생산 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100733012B1 (ko) * 2005-07-26 2007-06-28 재단법인서울대학교산학협력재단 복제된 개과 동물 및 이의 생산 방법
KR20090115025A (ko) * 2008-04-30 2009-11-04 황우석 개과 동물의 복제 생산 방법
KR20090115081A (ko) * 2008-04-30 2009-11-04 황우석 개과 동물의 복제 생산 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HONG, S.G. ET AL.: "Generation of red fluorescent protein transgenic dogs", GENESIS, vol. 47, 8 April 2009 (2009-04-08), pages 314 - 322, XP002613609, DOI: doi:10.1002/DVG.20504 *
VALERA, A. ET AL.: "Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus", PROC. NATL. ACAD.SCI. USA, vol. 91, September 1994 (1994-09-01), pages 9151 - 9154 *

Also Published As

Publication number Publication date
KR20110117841A (ko) 2011-10-28
WO2011132990A2 (ko) 2011-10-27

Similar Documents

Publication Publication Date Title
BR112013021785A2 (pt) método de criação de uma modificação genética, método de transferência de um alelo de uma célula ou embrião e método para produzir uma célula e um animal de gado geneticamente modificado
WO2007124751A3 (en) An animal model and a method for producing an animal model
WO2008103462A3 (en) Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
WO2011123708A3 (en) Genetic engineering of non-human animals for the production of chimeric antibodies
WO2014071397A3 (en) Genetically modified non-human animals and methods of use thereof
JP2017505127A5 (ko)
WO2014021715A3 (en) Gender, viability and/or developmental stage determination of avian embryos in ovo
WO2009071334A3 (en) Transposon-mediated mutagenesis in spermatogonial stem cells
JP2017528142A5 (ko)
WO2015077072A4 (en) Non-human animals having a humanized a proliferation-inducing ligand gene
RU2016123708A (ru) Отличные от человека животные, содержащие гуманизированный ген фактора активации в-клеток
EP2258166A4 (en) METHOD FOR PRODUCING FOUNDER ANIMAL FOR REPRODUCTIVE ANIMALS HAVING LETHAL PHENOTYPE DUE TO GENE MODIFICATION
UA109110C2 (ru) Полинуклеотид, который обеспечивает возможность специфической экспрессии в целых семенах однодольного растения
EP2578678A4 (en) PROCESS FOR PRODUCING TUMOR CELLS
McKay et al. An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning
PH12017501589A1 (en) Etv2 and uses thereof
WO2011132990A3 (ko) Ｐｅｐｃｋ 과발현 형질전환 복제 개과 동물 및 이의 생산방법
NZ719493A (en) Compositions and methods for producing genetically modified animals
WO2009066934A3 (en) Methods for improvement of birth rates in canidae on somatic cell nuclear transfer
MX2015006810A (es) Animales no humanos clonados libres de marcadores selectivos.
SG170025A1 (en) Improved methods of producing avian eggs and birds of specified germ-free status
MX2018000071A (es) Musculo cardiaco humanizado.
WO2012158594A3 (en) Crop plants with improved water use efficiency and grain yield and methods of marking them
WO2009088189A3 (ko) 형질전환된 복제개의 생산방법
WO2008084566A1 (ja) モデルマウス、その製造方法およびその用途

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11772278

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11772278

Country of ref document: EP

Kind code of ref document: A2