WO2011121859A1 - 検出素子 - Google Patents
検出素子 Download PDFInfo
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- WO2011121859A1 WO2011121859A1 PCT/JP2010/072163 JP2010072163W WO2011121859A1 WO 2011121859 A1 WO2011121859 A1 WO 2011121859A1 JP 2010072163 W JP2010072163 W JP 2010072163W WO 2011121859 A1 WO2011121859 A1 WO 2011121859A1
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- WIPO (PCT)
- Prior art keywords
- cover member
- space
- detection element
- inspection
- vibrator
- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G3/00—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances
- G01G3/12—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the weighing element is in the form of a solid body stressed by pressure or tension during weighing
- G01G3/16—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the weighing element is in the form of a solid body stressed by pressure or tension during weighing measuring variations of frequency of oscillations of the body
- G01G3/165—Constructional details
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2481—Wireless probes, e.g. with transponders or radio links
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
- G01N5/02—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by absorbing or adsorbing components of a material and determining change of weight of the adsorbent, e.g. determining moisture content
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/025—Change of phase or condition
- G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/025—Change of phase or condition
- G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/04—Wave modes and trajectories
- G01N2291/042—Wave modes
- G01N2291/0426—Bulk waves, e.g. quartz crystal microbalance, torsional waves
Definitions
- the present invention relates to a detection element using a vibrator.
- Patent Document 1 a resonance vibrator mass detection device that detects a detection object by detecting a change in resonance frequency of a piezoelectric vibrator wirelessly without using an electrode
- This resonance vibrator mass detection apparatus includes a piezoelectric vibrator, a sample supply unit, an electric field supply unit, and a signal analysis unit.
- the electric field supply means has an input means for inputting a voltage and a receiving means for receiving the vibration of the piezoelectric vibrator.
- the piezoelectric vibrator vibrates due to the piezoelectric effect when an oscillating electric field is applied.
- the sample supply means supplies a sample material to the surface of the piezoelectric vibrator.
- the input means of the electric field supply means inputs a voltage and applies the oscillating electric field to the piezoelectric vibrator.
- the receiving means of the electric field supply means receives the vibration of the piezoelectric vibrator. Based on the vibration of the piezoelectric vibrator received by the receiving means, the signal analysis unit detects a change in the resonance frequency caused by the detection target attached to the piezoelectric vibrator and detects the detection target.
- Patent Document 1 the resonance vibrator mass detector disclosed in Patent Document 1 has a problem that it is difficult to ensure stable vibration of the piezoelectric vibrator.
- the present invention has been made to solve such a problem, and an object thereof is to provide a detection element capable of ensuring stable vibration of the vibrator.
- the detection element includes a cover member, an introduction path, a discharge path, a vibrator, and first to third antennas.
- the cover member has an inspection space into which a liquid to be inspected is introduced and a minute space opened to the inspection space.
- the introduction path is provided in the cover member and introduces the liquid into the examination space.
- the discharge path is provided in the cover member and discharges the liquid from the inspection space.
- the vibrator is arranged in the examination space, has a size larger than the size of the examination space, and has an edge portion inserted into the minute space.
- the first antenna is connected to the ground potential.
- the second antenna applies an electromagnetic field to the vibrator in cooperation with the first antenna.
- the third antenna receives a reception signal including a vibration signal when the vibrator vibrates in cooperation with the first antenna from the vibrator.
- the cover member includes first to third cover members.
- the first cover member includes a first recess having a substantially U-shaped cross section, and a second recess having a substantially L-shaped cross section provided continuously from an edge of the first recess.
- the second cover member has a through hole having substantially the same size as the first recess, the through hole faces the first recess, and a portion other than the through hole is one main surface of the first cover member.
- a minute space is configured by being arranged in contact with the.
- the third cover member is disposed in contact with the surface of the second cover member opposite to the surface in contact with the first cover member, and constitutes an inspection space together with the first recess and the through hole.
- the first and third cover members are made of glass, and the second cover member is made of silicon.
- the cover member further includes m (m is a positive integer) number of protrusions formed on the lower surface of the minute space located below the edge of the vibrator inserted into the minute space. .
- the edge portion of the vibrator is arranged on m protrusions.
- the n protrusions include three or more protrusions that support the vibrator substantially horizontally.
- the cover member further includes k (k is an integer of 2 or more) support members that support a part of the side surface portion of the vibrator.
- the detection element includes a cover member, a plurality of introduction paths, a plurality of discharge paths, a plurality of vibrators, and first to third antennas.
- the cover member includes a plurality of inspection spaces into which the liquid to be inspected is introduced, and a plurality of minute spaces that are provided corresponding to the plurality of inspection spaces and that open to the corresponding inspection spaces, respectively. Have inside.
- the plurality of introduction paths are provided in the cover member corresponding to the plurality of inspection spaces, and each introduces liquid into the corresponding inspection space.
- the plurality of discharge paths are provided in the cover member corresponding to the plurality of inspection spaces, and each discharges liquid from the corresponding inspection space.
- the plurality of vibrators are provided corresponding to the plurality of examination spaces, each of which is arranged in the corresponding examination space, has a size larger than the size of the examination space, and is an edge inserted into the minute space Part.
- the first antenna is connected to the ground potential.
- the second antenna applies an electromagnetic field to the plurality of vibrators in cooperation with the first antenna.
- the third antenna receives a reception signal including a vibration signal when the vibrator vibrates in cooperation with the first antenna from the plurality of vibrators.
- the detection element further includes an auxiliary cover member.
- the auxiliary cover member is disposed in contact with the cover member and has a plurality of auxiliary paths.
- Each of the plurality of auxiliary paths is provided corresponding to the discharge path provided corresponding to one of the two adjacent test spaces and the other test space of the two test spaces. Connect the route.
- the detection element further includes an auxiliary cover member.
- the auxiliary cover member is disposed in contact with the cover member and has a plurality of auxiliary paths provided corresponding to the plurality of inspection spaces.
- Each of the plurality of auxiliary paths includes a first auxiliary path for introducing liquid from the outside into an introduction path provided corresponding to the corresponding inspection space, and a discharge path provided corresponding to the corresponding inspection space. And a second auxiliary route for discharging the gas to the outside.
- the detection element includes a plurality of unit elements and first to third antennas.
- the first antenna is connected to the ground potential.
- the second antenna applies an electromagnetic field to a plurality of vibrators included in the plurality of unit elements in cooperation with the first antenna.
- the third antenna receives a reception signal including a vibration signal when the vibrator vibrates in cooperation with the first antenna from the plurality of vibrators.
- Each of the plurality of unit elements includes a cover member, an introduction path, a discharge path, and a vibrator.
- the cover member has an inspection space into which a liquid to be inspected is introduced and a minute space opened to the inspection space.
- the introduction path is provided in the cover member and introduces the liquid into the examination space.
- the discharge path is provided in the cover member and discharges the liquid from the inspection space.
- the vibrator is arranged in the examination space, has a size larger than the size of the examination space, and has an edge portion inserted into the minute space.
- the detection element further includes an auxiliary cover member.
- the auxiliary cover member is disposed in contact with the plurality of cover members included in the plurality of unit elements, and each of the plurality of auxiliary members connects two adjacent inspection spaces among the plurality of inspection spaces included in the plurality of unit elements. Have a route.
- Each of the plurality of auxiliary paths includes a discharge path provided corresponding to one inspection space of the two inspection spaces, and an introduction path provided corresponding to the other inspection space of the two inspection spaces. Connect.
- the detection element further includes an auxiliary cover member.
- the auxiliary cover member is disposed in contact with the plurality of cover members included in the plurality of unit elements, and has a plurality of auxiliary paths provided corresponding to the plurality of inspection spaces included in the plurality of unit elements.
- Each of the plurality of auxiliary paths includes a first auxiliary path for introducing liquid from the outside into an introduction path provided corresponding to the corresponding inspection space, and a discharge path provided corresponding to the corresponding inspection space. And a second auxiliary route for discharging the gas to the outside.
- the plurality of vibrators have substantially the same thickness.
- the plurality of vibrators have different thicknesses.
- the detection element includes a vibrator having an edge portion inserted into a minute space.
- FIG. 2 is a cross-sectional view of a detection element between line II-II shown in FIG.
- FIG. 3 is a cross-sectional view of the detection element taken along line III-III shown in FIG.
- FIG. 3 is an enlarged view of an inspection space and a minute space shown in FIG. 2. It is a figure which shows the specific dimension of the test
- FIG. 4 is an enlarged view of an introduction path, a discharge path, and an inspection space shown in FIG. 3.
- FIG. 3 is a perspective view and a sectional view of three cover members shown in FIG. 2. It is process drawing which shows the manufacturing method of the detection element shown in FIGS.
- FIG. 4 is a timing chart of an input voltage Vin and a reception signal R. It is a timing chart of resonance frequency. It is the schematic of the other detection element by embodiment of this invention. It is a figure which shows the specific example of the detection element shown in FIG. It is a block diagram of the cover member shown in FIG. It is a figure which shows the other specific example of the detection element shown in FIG. It is a block diagram of the cover member shown in FIG. It is a top view of the other detection element by embodiment of this invention.
- FIG. 17 is a cross-sectional view of the detection element between line XVII-XVII shown in FIG. It is sectional drawing of the further another detection element by embodiment of this invention.
- FIG. 19 is an enlarged view of the inspection space and the minute space shown in FIG. 18.
- FIG. 19 is another enlarged view of the inspection space and the minute space shown in FIG. 18.
- FIG. 19 is another enlarged view of the inspection space and the minute space shown in FIG. 18.
- FIG. 19 is another enlarged view of the inspection space and the minute space shown in FIG. 18.
- FIG. 26 is a process chart showing a method for manufacturing the detection element shown in FIGS. 24 and 25. It is sectional drawing of the further another detection element by embodiment of this invention.
- FIG. 20 is a process diagram illustrating another method for manufacturing the detection element illustrated in FIGS. 18 and 19. It is a figure which shows another vibrator
- FIG. 1 is a plan view of a detection element according to an embodiment of the present invention.
- 2 is a cross-sectional view of the detection element taken along line II-II shown in FIG.
- FIG. 3 is a cross-sectional view of the detection element taken along line III-III shown in FIG.
- a detection element 10 includes a cover member 1 to 3, a vibrator 4, an introduction port 5, an introduction path 6, a discharge path 7, and a discharge path.
- An outlet 8 and antennas 9, 11, and 12 are provided.
- the cover member 1 is made of, for example, glass and has a square planar shape. And the thickness of the cover member 1 is 200 micrometers, for example.
- the cover member 2 is made of, for example, silicon (Si) and has a square planar shape. And the thickness of the cover member 2 is 50 micrometers, for example.
- the cover member 3 is made of, for example, glass and has a square planar shape. And the thickness of the cover member 3 is 300 micrometers, for example.
- the cover member 2 is disposed in contact with the cover members 1 and 3, and the cover member 3 is disposed in contact with the cover member 2.
- the cover member 2 is joined to the cover member 1 by anodic bonding
- the cover member 3 is joined to the cover member 2 by anodic bonding.
- the cover members 1 to 3 constitute the inspection space 13 and the minute space 14 inside.
- the inspection space 13 is a space into which a liquid to be inspected is introduced.
- the minute space 14 is open to the inspection space 13.
- the vibrator 4 is made of, for example, quartz and has a substantially rectangular planar shape. Further, the thickness of the vibrator 4 is 10 ⁇ m, for example, and the size of the vibrator 4 is 3 mm square, for example.
- the vibrator 4 is disposed in the inspection space 13 and the edge thereof is inserted into the minute space 14.
- the introduction port 5 is provided in the cover members 1 and 2.
- the introduction port 5 is a port for introducing the liquid to be inspected into the detection element 10 from the outside.
- the introduction path 6 is provided in the cover members 1 and 2.
- the introduction path 6 has one end connected to the introduction port 5 and the other end connected to the inspection space 13 and the minute space 14.
- the introduction path 6 includes introduction paths 6a and 6b.
- the introduction path 6a is meandering, and has one end connected to the introduction port 5 and the other end connected to the introduction path 6b.
- the introduction path 6 b has one end connected to the introduction path 6 a and the other end connected to the examination space 13.
- the introduction path 6a meanders in order to stabilize the flow of the liquid to be inspected.
- the discharge path 7 has one end connected to the inspection space 13 and the other end connected to the discharge port 8.
- the discharge port 8 is provided in the cover members 1 and 2.
- the discharge port 8 is a port for discharging the liquid to be inspected from the inspection element 10 to the outside.
- Each of the antennas 9, 11, and 12 is made of, for example, a copper wire having a diameter of 0.2 mm ⁇ to 1 mm ⁇ .
- Each of the antennas 9 and 11 is disposed along the surface of the cover member 1.
- Each of the antennas 9 and 11 is arranged such that one end side thereof is disposed above the vibrator 4 and the other end side thereof is pulled out of the detection element 10.
- the antenna 12 is disposed along the back surface of the cover member 3. Then, one end side of the antenna 12 is arranged below the vibrator 4, and the other end side is drawn out of the detection element 10.
- the antennas 9 and 11 are arranged on the same side with respect to the vibrator 4, and the antenna 12 is arranged on the opposite side of the antennas 9 and 11 with respect to the vibrator 4.
- the vibrator 4 vibrates when an electromagnetic field is applied by the antennas 9 and 12.
- the introduction path 6 guides the liquid introduced from the introduction port 5 to the inspection space 13.
- the discharge path 7 guides the liquid in the inspection space 13 to the discharge port 8.
- the antenna 9 applies an electromagnetic field to the vibrator 4 in cooperation with the antenna 12.
- the antenna 11 receives a reception signal composed of a vibration signal when the vibrator 4 vibrates when an electromagnetic field is applied in cooperation with the antenna 12.
- the antenna 12 is connected to the ground potential.
- the detection element 10 detects the detection object from the liquid to be inspected by detecting the vibration of the vibrator 4 in a non-contact manner.
- FIG. 4 is an enlarged view of the inspection space 13 and the minute space 14 shown in FIG.
- inspection space 13 has a width W1 and a height H1.
- the width W1 is, for example, 2.98 mm.
- the height H1 is, for example, 120 to 130 ⁇ m.
- Each of the heights H2 and H4 is, for example, 50 ⁇ m.
- the height H3 is, for example, 20 to 30 ⁇ m.
- the micro space 14 has a width W2 and a height H3.
- the width W2 is, for example, 15 ⁇ m.
- FIG. 5 is a diagram showing specific dimensions of the inspection space 13 and the minute space 14 shown in FIG. As described above, the length of one side of the vibrator 4 is 3 mm. Therefore, when the vibrator 4 is arranged at the center of the inspection space 13, the edge 41 on one side of the vibrator 4 is inserted into the one minute space 14 by 10 ⁇ m, and the edge on the other side of the vibrator 4. The part 42 is also inserted into the other minute space 14 by 10 ⁇ m. The distance between the edge 41 and the side wall 14A of the minute space 14 is 5 ⁇ m, and the distance between the edge 42 and the side wall 14B of the minute space 14 is 5 ⁇ m.
- the distance between the other end of the vibrator 4 and the side wall 14B of the minute space 14 is 10 ⁇ m. Even when the vibrator 4 rotates counterclockwise, the edge portions 41 and 42 of the vibrator 4 remain inserted into the minute space 14 as indicated by the dotted line. Similarly, when the vibrator 4 rotates clockwise, the edges 41 and 42 of the vibrator 4 remain inserted into the minute space 14 (see FIG. 5B).
- FIG. 6 is an enlarged view of the introduction path 6, the discharge path 7, and the inspection space 13 shown in FIG. 3.
- the inspection space 13 has the dimensions described above.
- the height H5 of the introduction path 6 and the discharge path 7 is, for example, 80 ⁇ m and is higher than the above-described height H4. As a result, the liquid to be inspected is introduced from the introduction path 6 to both sides of the vibrator 4.
- the width of the introduction path 6 and the discharge path 7 (the length in the direction perpendicular to the paper surface of FIG. 6) is narrower than the length of one side of the vibrator 4, also in the cross section between lines III-III shown in FIG.
- the vibrator 4 does not protrude from the minute space 14 to the introduction path 6 side or the discharge path 7 side.
- the vibrator 4 has a structure that does not protrude from the minute space 14 around the vibrator 4.
- FIG. 7 is a perspective view and a sectional view of the three cover members 1 to 3 shown in FIG.
- FIG. 7 shows the positional relationship between the cover member 1 and the cover member 3 reversed in the vertical direction.
- the cross-sectional views shown in FIGS. 7D to 7F are cross-sectional views taken along the line II-II shown in FIG. 1, and the cross-sectional views shown in FIGS. 3 is a cross-sectional view taken along line III-III shown in FIG.
- the cover member 1 has recesses 101, 102, 104, 105 and through holes 103, 106.
- the recess 101 has a substantially U-shaped cross-sectional shape.
- the recess 102 is provided continuously to the edge of the recess 101 and has a substantially L-shaped cross-sectional shape.
- the recess 102 is provided around the recess 101.
- the through hole 103 penetrates the cover member 1.
- the recess 104 is provided between the recess 102 and the through hole 103.
- the recess 105 is provided between the recess 102 and the through hole 106.
- the through hole 106 passes through the cover member 1.
- the cover member 2 has through holes 201 and 203 to 206.
- the through hole 201 has the same shape and the same size as the concave portion 101 of the cover member 1.
- the through holes 201 and 203 to 206 face the concave portion 101, the through hole 103, the concave portions 104 and 105, and the through hole 106, respectively, and a portion 202 other than the through holes 201 and 203 to 206 is a main surface 1A of the cover member 1.
- the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8 and the minute space 14 are formed.
- the cover member 3 is disposed in contact with the surface of the cover member 2 opposite to the surface in contact with the cover member 1, an inspection space 13 is formed.
- the joining of the cover member 1 and the cover member 2 is performed by anodic joining to which a voltage of 400 V is applied at a temperature of 200 ° C. Also, the cover member 2 and the cover member 3 are joined by anodic joining with a voltage of 400 V applied at a temperature of 200 ° C.
- the detection element 10 has a structure in which the edge of the vibrator 4 is inserted into the minute space 14. As a result, the vibrator 4 is not held by the cover members 1 to 3 and vibrates freely when an electromagnetic field is applied by the antennas 9 and 12.
- FIG. 8 is a process diagram showing a method for manufacturing the detection element 10 shown in FIGS. 1 to 3.
- recesses 101, 102, 104, 105, and 105 are formed on one main surface of glass constituting cover member 1 using photolithography and etching in semiconductor technology.
- the through holes 103 and 106 are formed (step S1).
- the etching includes both dry etching and wet etching (the same applies hereinafter).
- step S2 through holes 201, 203 to 206 are formed in the silicon constituting the cover member 2 using photolithography and etching.
- the vibrator 4 having a desired size and thickness is formed by using etching or mechanical polishing (step S3).
- the vibrator 4 is disposed on the cover member 1 so that the edge portion is disposed on the recess 102 of the cover member 1 (step S4).
- step S5 Joining (step S5). Thereby, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, and the minute space 14 are formed.
- step S6 the cover member 3 is disposed in contact with the surface of the cover member 2 opposite to the surface in contact with the cover member 1, and the cover member 3 is joined to the cover member 2 by the anodic bonding described above (step S6). Thereby, the inspection space 13 is formed.
- step S7 antennas 9, 11, and 12 are formed. Thereby, the detection element 10 is completed.
- FIG. 9 is a timing chart of the input voltage Vin and the received signal R.
- FIG. 10 is a timing chart of the resonance frequency.
- the detection method of the detection target in the detection element 10 is demonstrated.
- an application circuit (not shown) applies an input voltage Vin having a vibration waveform to the antenna 9 from timing t1 to timing t2. Then, the application circuit stops applying the input voltage Vin to the antenna 9 after the timing t2.
- the antenna 11 cooperates with the antenna 12 to receive the potential distribution generated on the surface of the vibrator 4 as a reception signal R having a vibration waveform.
- the antenna 11 receives a reception signal R0 having a vibration waveform if the detection target object is not attached to the vibrator 4, and has a vibration waveform if the detection target object is attached to the vibrator 4.
- Receive signal R1 is received.
- the antenna 11 outputs the received reception signals R0 and R1 to a detection circuit (not shown).
- the mass of the vibrator 4 increases, so that the resonance frequency f1 of the vibrator 4 decreases compared to the case where the object to be detected does not adhere to the vibrator 4.
- the detection circuit receives the reception signal R from the antenna 11 after the input voltage Vin is applied to the antenna 9, and when the detection target is not attached to the vibrator 4, the detection circuit calculates the resonance frequency f0 from the reception signal R.
- the resonance frequency f that gradually changes to the resonance frequency f1 is detected (see FIG. 10).
- the change amount of the resonance frequency of the vibrator 4 ⁇ f is expressed by the following equation.
- the liquid to be inspected is introduced into the inspection space 13 through the introduction port 5 and the introduction path 6, and the liquid to be inspected is discharged from the inspection space 13 through the discharge path 7 and the discharge port 8.
- the detection target is detected by the above-described method while circulating the liquid to be inspected.
- the vibrator 4 is not sandwiched between the cover members 1 to 3 as described above, and therefore vibrates freely when an electromagnetic field is applied by the antennas 9 and 12. Therefore, it is possible to detect the detection target while ensuring stable vibration of the vibrator 4.
- the surface of the crystal constituting the vibrator 4 is covered with OH groups, and the protein is easily adsorbed to the vibrator 4.
- the protein is easily adsorbed to the vibrator 4 without using a silane coupling agent and a self-assembled monolayer (SAM) reagent.
- SAM self-assembled monolayer
- ultrapure water is circulated through the introduction port 5, the introduction route 6, the inspection space 13, the minute space 14, the discharge route 7 and the discharge port 8, and the vibrator 4 is washed.
- the detection element 10 can be used semipermanently.
- FIG. 11 is a schematic view of another detection element according to the embodiment of the present invention.
- the detection element according to the embodiment of the present invention may be the detection element 100 shown in FIG.
- the detection element 100 includes unit elements 91 to 9n (n is an integer of 2 or more) and antennas 110, 120, and 130.
- Each of the unit elements 91 to 9n includes the cover members 1 to 3 of the detection element 10, the vibrator 4, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, the inspection space 13, and the minute space 14. .
- the unit elements 91 to 9n are arranged in a line so that, for example, straight lines connecting the inlet 5 and the outlet 8 are parallel.
- the antennas 110, 120, and 130 correspond to the antennas 9, 11, and 12 of the detection element 10, respectively.
- the antennas 110 and 120 are arranged on one side of the unit elements 91 to 9n and above the n transducers 4 included in the unit elements 91 to 9n.
- the antenna 130 is disposed below the n transducers 4 included in the unit elements 91 to 9n on the other side of the unit elements 91 to 9n.
- the antennas 110, 120, and 130 are arranged in common for the n unit elements 91 to 9n.
- the antenna 110 applies an electromagnetic field to the n vibrators 4 of the unit elements 91 to 9n in cooperation with the antenna 130.
- the antenna 120 receives a reception signal including a vibration signal when the n vibrators 4 of the unit elements 91 to 9n vibrate in cooperation with the antenna 130.
- the n vibrators 4 of the unit elements 91 to 9n may have the same thickness or may have different thicknesses.
- the detection element 100 detects the same type of detection object by the unit elements 91 to 9n.
- the detection element 100 detects different types of detection objects depending on the unit elements 91 to 9n.
- FIG. 12 is a diagram showing a specific example of the detection element 100 shown in FIG. 12A is a plan view, and FIG. 12B is a side view.
- detection element 100 ⁇ / b> A has a configuration in which cover member 140 is added to detection element 100.
- the cover member 140 is disposed on the unit elements 91 to 9n.
- the cover member 140 includes auxiliary paths 141 to 14n + 1 and holes 151 to 15 (2n).
- the cover member 140 is made of glass, for example.
- the auxiliary path 141 has one end located on the end surface of the cover member 140 and the other end connected to the hole 151.
- the auxiliary path 142 has one end connected to the hole 152 and the other end connected to the hole 153.
- the auxiliary path 143 has one end connected to the hole 154.
- the auxiliary path 14n has the other end connected to the hole 15 (2n-1), and the auxiliary path 14n + 1 has one end connected to the hole 15 (2n).
- the hole 151 is connected to the introduction port 5 of the unit element 91.
- the hole 152 is connected to the discharge port 8 of the unit element 91.
- the hole 153 is connected to the discharge port 8 of the unit element 92.
- the hole 154 is connected to the introduction port 5 of the unit element 92.
- the hole 15 (2n-1) is connected to the inlet 5 of the unit element 9n, and the hole 15 (2n) is connected to the outlet 8 of the unit element 9n.
- the liquid to be inspected is introduced into the detection device 100A from the auxiliary path 141, sequentially flows through the unit elements 91, 92,..., 9n, and discharged from the auxiliary path 14n + 1 to the outside. In this case, the liquid is introduced into the unit element 92 from the discharge port 8 and discharged from the introduction port 5.
- the cover member 140 connects n unit elements 91 to 9n in series.
- the n vibrators 4 included in the n unit elements 91 to 9n have the same thickness.
- FIG. 13 is a configuration diagram of the cover member 140 shown in FIG. Referring to FIG. 13, cover member 140 includes cover members 1410 and 1420. Each of the cover members 1410 and 1420 is made of glass.
- the cover member 1410 includes grooves 1411 to 141n + 1 on one main surface 1410A. One end of the groove 1411 is located on the end surface of the cover member 1410. The other end of the groove 141n + 1 is located on the end surface of the cover member 1410.
- the cover member 1420 includes through holes 1421 to 14 (2n). Each of the through holes 1421 to 14 (2n) has a diameter substantially equal to the width of the grooves 1411 to 141n + 1.
- the cover member 1410 is joined to the cover member 1420 by the anodic bonding described above so that the one principal surface 1410A of the cover member 1410 is in contact with the one principal surface 1420A of the cover member 1420.
- the through hole 1421 is connected to the other end of the groove 1411
- the through hole 1422 is connected to one end of the groove 1412
- the through hole 142 (2n) is connected to one end of the groove 141n + 1.
- the grooves 1411 to 141n + 1 constitute auxiliary paths 141 to 14n + 1, respectively, by opening an opening on one main surface 1410A of the cover member 1410 with the one main surface 1420A of the cover member 1420.
- the through holes 1421 to 14 (2n) constitute holes 151 to 15 (2n), respectively.
- the detection element 100A is manufactured by the following method. First, n unit elements 91 to 9n are manufactured by repeating the steps S1 to S5 shown in FIG. 8 n times.
- the n unit elements 91 to 9n are arranged in a line in the manner shown in FIG. 11, and the antennas 110, 120, and 130 are arranged to produce the detection element 100.
- grooves 1411 to 141n + 1 are formed on one main surface 1410A using photolithography and etching, and a cover member 1410 is manufactured. Further, through holes 1421 to 14 (2n) are formed using photolithography and etching, and the cover member 1420 is manufactured.
- cover member 1410 and the cover member 1420 are joined by anodic bonding so that one main surface 1410A of the cover member 1410 is in contact with the main surface 1420A of the cover member 1420. Thereby, the cover member 140 is produced.
- the cover member 140 is arranged on the n unit elements 91 to 9n so that the holes 151 to 15 (2n) of the cover member 140 are connected to the introduction port 5 or the discharge port 8.
- the detection element 100A is completed.
- the detection method of the detection target in the detection element 100A will be described.
- the liquid to be inspected is introduced into the detection element 100A from the auxiliary path 141, and the liquid is circulated through the n unit elements 91 to 9n in series by discharging the liquid from the auxiliary path 14n + 1.
- an electromagnetic field is applied to the n vibrators 4 of the n unit elements 91 to 9n by the antennas 110 and 130. Thereafter, the antennas 120 and 130 receive a reception signal composed of vibration signals of the n vibrators 4. Then, a change amount ⁇ f of the resonance frequency of the vibration signal is detected, and a detection target is detected.
- the strong acid described above is flowed into the n test spaces 13 of the n unit elements 91 to 9n in the same manner as the liquid to be tested, and the n vibrators 4 are washed.
- ultrapure water is passed through the n inspection spaces 13 of the n unit elements 91 to 9n, and the n vibrators 4 are washed.
- FIG. 14 is a diagram showing another specific example of the detection element 100 shown in FIG. 14A is a plan view, and FIG. 14B is a side view.
- the detection element 100 ⁇ / b> B has a configuration in which a cover member 160 is added to the detection element 100.
- the cover member 160 is disposed on the unit elements 91 to 9n.
- the cover member 160 includes auxiliary paths 161 to 16 (2n).
- the cover member 160 is made of glass, for example.
- the auxiliary path 161 has one end located on the end face of the cover member 160 and the other end connected to the introduction port 5 of the unit element 91.
- the auxiliary path 162 has one end connected to the discharge port 8 of the unit element 91 and the other end positioned on the end surface of the cover member 160.
- the auxiliary path 163 has one end located on the end surface of the cover member 160 and the other end connected to the inlet 5 of the unit element 92.
- the auxiliary path 164 has one end connected to the discharge port 8 of the unit element 92 and the other end positioned on the end surface of the cover member 160.
- the auxiliary path 16 (2n-1) has one end located on the end face of the cover member 160 and the other end connected to the introduction port 5 of the unit element 9n.
- the auxiliary path 16 (2n) has one end connected to the discharge port 8 of the unit element 9n and the other end positioned on the end surface of the cover member 160.
- the liquid to be inspected is introduced into the unit elements 91 to 9n from the auxiliary paths 161, 163,..., 16 (2n-1), respectively, and the auxiliary paths 162, 164,. 16 (2n) is discharged to the outside.
- the liquid to be inspected is caused to flow in parallel to the unit elements 91 to 9n by the cover member 160.
- the n vibrators 4 included in the n unit elements 91 to 9n may have the same thickness or may have different thicknesses. Good.
- FIG. 15 is a configuration diagram of the cover member 160 shown in FIG. Referring to FIG. 15, cover member 160 includes cover members 1610 and 1620. Each of the cover members 1610 and 1620 is made of glass.
- the cover member 1610 includes grooves 1611 to 161 (2n) on one main surface 1610A. One end of the groove 1611 is located on the end surface 1610B of the cover member 1610. One end of the groove 1612 is located on the end surface 1610 ⁇ / b> C of the cover member 1610.
- the groove 1613 has one end located on the end surface 1610B of the cover member 1610.
- One end of the groove 1614 is located on the end surface 1610 ⁇ / b> C of the cover member 1610.
- one end of the groove 161 (2n-1) is located on the end face 1610B of the cover member 1610, and one end of the groove 161 (2n) is located on the end face 1610C of the cover member 1610.
- the cover member 1620 includes through holes 1621 to 16 (2n). Each of through holes 1621 to 16 (2n) has a diameter substantially equal to the width of grooves 1611 to 161 (2n).
- the cover member 1610 is joined to the cover member 1620 by the anodic bonding described above so that the one principal surface 1610A of the cover member 1610 is in contact with the one principal surface 1620A of the cover member 1620.
- the through hole 1621 is connected to the other end of the groove 1611
- the through hole 1622 is connected to the other end of the groove 1612
- the through hole 1623 is connected to the other end of the groove 1613
- the through hole 1624 is
- the through hole 162 (2n) is connected to the other end of the groove 161 (2n-1)
- the through hole 162 (2n) is connected to the groove 161 (2n).
- the openings on the one principal surface 1610A of the grooves 1611 to 161 (2n) are closed by the one principal surface 1620A of the cover member 1620, so that the grooves 1611 to 161 (2n) and the through holes 1621 to 16 (2n) are formed.
- the auxiliary paths 161 to 16 (2n) are respectively configured.
- the detection element 100B is manufactured by the following method. First, n unit elements 91 to 9n are manufactured by repeating the steps S1 to S5 shown in FIG. 8 n times.
- the n unit elements 91 to 9n are arranged in a line in the manner shown in FIG. 11, and the antennas 110, 120, and 130 are arranged to produce the detection element 100.
- grooves 1611 to 161 (2n) are formed on one main surface 1610A using photolithography and etching, and a cover member 1610 is manufactured. Further, through holes 1621 to 16 (2n) are formed by using photolithography and etching, and the cover member 1620 is manufactured.
- cover member 1610 and the cover member 1620 are joined by anodic bonding so that the one principal surface 1610A of the cover member 1610 is in contact with the one principal surface 1620A of the cover member 1620. Thereby, the cover member 160 is produced.
- auxiliary paths 161, 162; 163, 164; ...; 16 (2n-1), 16 (2n) of the cover member 160 are connected to the introduction port 5 and the discharge port 8, respectively. Arranged on the n unit elements 91 to 9n.
- the detection element 100B is completed.
- the detection method of the detection target in the detection element 100B will be described.
- the n vibrators 4 included in the n unit elements 91 to 9n have the same thickness, the same type of liquid to be inspected is supplied to the auxiliary paths 161, 163, ..., 16 (2n-1 ) From the auxiliary paths 162, 164,..., 16 (2n) in parallel to circulate the liquid through the n unit elements 91 to 9n in parallel. .
- an electromagnetic field is applied to the n vibrators 4 of the n unit elements 91 to 9n by the antennas 110 and 130. Thereafter, the antennas 120 and 130 receive a reception signal composed of vibration signals of the n vibrators 4. Then, a change amount ⁇ f of the resonance frequency of the vibration signal is detected, and a detection target is detected.
- the strong acid described above is caused to flow in parallel in the n test spaces 13 of the n unit elements 91 to 9n in the same manner as the liquid to be tested, and the n vibrators 4 are washed. To do.
- ultrapure water is caused to flow in parallel in the n inspection spaces 13 of the n unit elements 91 to 9n, and the n vibrators 4 are washed.
- the n vibrators 4 included in the n unit elements 91 to 9n have different thicknesses
- the n different types of liquids are supplied to the auxiliary paths 161, 163, ..., 16 (2n- 1) is introduced into the detection element 100B in parallel, and liquids are discharged in parallel from the auxiliary paths 162, 164,..., 16 (2n), thereby allowing n types of liquids to be supplied to the n unit elements 91 to 9n. Cycle in parallel.
- the antennas 110 and 130 receive a reception signal composed of vibration signals of the n vibrators 4. Then, a change amount ⁇ f of the resonance frequency of the vibration signal is detected, and a detection target is detected.
- the strong acid described above is caused to flow in parallel in the n test spaces 13 of the n unit elements 91 to 9n in the same manner as the liquid to be tested, and the n vibrators 4 are washed. To do.
- ultrapure water is caused to flow in parallel in the n inspection spaces 13 of the n unit elements 91 to 9n, and the n vibrators 4 are washed.
- a detection target may be detected by circulating a liquid through some of the n unit elements 91 to 9n.
- the detection element 100B sets the thickness of the vibrator 4 to the same or different thickness, and detects a detection target in the same type of liquid or n types of liquids.
- FIG. 16 is a plan view of still another detection element according to the embodiment of the present invention.
- FIG. 17 is a cross-sectional view of the detection element 300 along the line XVII-XVII shown in FIG.
- the detection element according to the embodiment of the present invention may be the detection element 300 shown in FIGS.
- the detection element 300 includes a cover member 310, elements 301 to 30n, and antennas 110, 120, and 130.
- the cover member 310 includes cover members 311 to 313. Each of the cover members 311 and 313 is made of glass, for example.
- the cover member 312 is made of Si, for example.
- the cover members 311 to 313 have the same thickness as the cover members 1 to 3 described above.
- Each of the elements 301 to 30n includes the vibrator 4, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, the inspection space 13, and the minute space 14 described above.
- the n elements 301 to 30n are formed in a row in the cover member 310 so that straight lines connecting the introduction port 5 and the discharge port 8 are parallel to each other.
- the antennas 110 and 120 are arranged on the upper surface 311A of the cover member 311 so as to be positioned above the n transducers 4 included in the n elements 301 to 30n.
- the antenna 130 is disposed on the lower surface 313A of the cover member 313 so as to be positioned below the n transducers 4 included in the n elements 301 to 30n.
- the detection element 300 is manufactured according to the process shown in FIG. In this case, cover members 1 to 3 are read as cover members 311 to 313, respectively, and antennas 9, 11, and 12 are read as antennas 110, 120, and 130, respectively.
- step S 1 n sets of recesses 101, 102, 104, 105 and n sets of through holes 103, 106 are formed in the cover member 311.
- step S 2 n through holes 201 and 203 to 206 are formed in the cover member 312.
- n vibrators 4 are formed in step S3. Further, in step S4, the n vibrators 4 are arranged in the n concave portions 102, respectively. Further, in step S5, the cover member 312 is brought into contact with the cover member 311 so that the n through holes 201, 203 to 206 face the n concave portions 102, 104, 105 and the n through holes 103, 106, The cover member 312 is bonded to the cover member 311 by anodic bonding.
- step S6 the cover member 313 is disposed in contact with the surface of the cover member 312 opposite to the surface in contact with the cover member 311, and the cover member 313 is joined to the cover member 312 by anodic bonding.
- step S7 the antennas 110 and 120 are arranged on the upper surface 311A of the cover member 311 so as to be positioned above the n transducers 4 included in the n elements 301 to 30n.
- the antenna 130 is disposed on the lower surface 313A of the cover member 313 so as to be positioned below the n transducers 4 included in 30n.
- a of the detection element 300 is configured by adding a cover member 140 to the detection element 300.
- the n elements 301 to 30n are connected in series by the cover member 140.
- the n vibrators 4 included in the n elements 301 to 30n have the same thickness.
- the specific example A of the detection element 300 is used semi-permanently while detecting the detection target by the same method as the detection method in the detection element 100A described above.
- Specific example B of the detection element 300 is configured by adding a cover member 160 to the detection element 300.
- the n vibrators 4 included in the n elements 301 to 30n have the same thickness or different thicknesses.
- the specific example B of the detection element 300 is used semi-permanently while detecting the detection target by the same method as the detection method in the detection element 100B described above.
- the n inspection spaces 13 are connected in series or in parallel.
- the detection elements 100 and 300 can detect one type or n types of detection objects from one type of liquid or n types of liquid.
- the n vibrators 4 are not sandwiched between the cover members 1 to 3 or the cover members 311 to 313, so that an electromagnetic field is applied. And vibrate freely.
- FIG. 18 is a cross-sectional view of still another detection element according to the embodiment of the present invention.
- FIG. 19 is an enlarged view of the examination space 13 and the minute space 14 shown in FIG. In FIG. 19, only the portion of the cover member 1 that forms the inspection space 13 and the minute space 14 that forms the side walls 14A and 14B of the minute space 14 is illustrated.
- the detection element according to the embodiment of the present invention may be the detection element 10A shown in FIGS. Referring to FIGS. 18 and 19, detection element 10 ⁇ / b> A is the same as detection element 10 except that cover member 2 of detection element 10 shown in FIGS. 1 to 3 is replaced with cover member 2 ⁇ / b> A. .
- the cover member 2 ⁇ / b> A is disposed between the cover member 1 and the cover member 3 in contact with both the cover members 1 and 3.
- the cover member 2A is made of the same material as the cover member 2.
- the height H3 of the minute space 14 is 70 to 80 ⁇ m.
- the height H1 of the inspection space 13 is 170 to 180 ⁇ m.
- the cover member 2A is the same as the cover member 2 except that protrusions 21 to 24 are added to the cover member 2 shown in FIG.
- Each of the protrusions 21 to 24 has a cylindrical shape, for example, and has a diameter of 50 ⁇ m ⁇ and a height of 50 ⁇ m.
- the protrusions 21 to 24 are arranged on the bottom surface 14C of the minute space 14. In this case, the protrusions 21 to 24 are arranged so as to be positioned at four vertices of a quadrangle similar to the quadrangle of the inspection space 13.
- the cover member 2A is integrally formed to have the protrusions 21 to 24.
- the vibrator 4 is disposed on the protrusions 21 to 24.
- the vibrator 4 comes into contact with only the four protrusions 21 to 24 at the edge, and the contact area between the vibrator 4 and the cover member 2A in the detection element 10A is the vibration in the detection element 10.
- the contact area between the child 4 and the cover member 2 becomes smaller, and the vibrator 4 vibrates more freely than the detection element 10. Therefore, free vibration of the vibrator can be ensured.
- the protrusions 21 to 24 support the vibrator 4 horizontally. As a result, when the detection target is detected while circulating the liquid to be inspected, the liquid to be inspected flows smoothly through the inspection space 13. Therefore, the detection target can be accurately detected while circulating the liquid to be inspected.
- Each of the protrusions 21 to 24 may have a pointed shape such as a hemispherical shape, a triangular pyramid, a quadrangular pyramid, or the like at the tip (contact portion with the vibrator 4).
- the tip portions of the projections 21 to 24 have a sharp shape such as a hemispherical shape, a triangular pyramid, and a quadrangular pyramid
- the vibrator 4 makes point contact with the projections 21 to 24. Therefore, the vibrator 4 and the projection 21
- the contact area with ⁇ 24 is further reduced. As a result, the vibrator 4 vibrates more freely. Therefore, free vibration of the vibrator can be ensured.
- FIG. 20 is a process diagram showing a method of manufacturing the detection element 10A shown in FIGS.
- FIG. 20 when manufacturing of detection element 10 ⁇ / b> A is started, recesses 101, 102, 104, 105, and the like are formed on one main surface of glass constituting cover member 1 using photolithography and etching in semiconductor technology.
- the through holes 103 and 106 are formed (step S11).
- the recesses 101, 102, 104, 105 and the through holes 103, 106 have different depths, the resist coating, the resist patterning, and the etching are repeated in the order of shallowness, and the recesses 101, 102, 104, 105 and through holes 103 and 106 are formed.
- projections 21 to 24 and through holes 201 and 203 to 206 are formed on the silicon constituting the cover member 2A by using photolithography and etching (step S12).
- resist coating, resist patterning, and etching are repeated to form the projections 21 to 24 and then the through holes 201 and 203 to 206 are formed.
- the vibrator 4 having a desired size and thickness is formed by using etching or mechanical polishing (step S13).
- the cover member 2A is brought into contact with the cover member 3 so that the protrusions 21 to 24 of the cover member 2A are on the upper side, and the cover member 2A is joined to the cover member 3 by the anodic bonding described above (step S14).
- step S15 the vibrator 4 is disposed on the protrusions 21 to 24 of the cover member 2A.
- the cover member 1 is brought into contact with the cover member 2A so that the concave portions 101, 104 and the through holes 103, 106 of the cover member 1 face the through holes 201, 203-206 of the cover member 2A, and the cover member is subjected to the anodic bonding described above. 1 is joined to the cover member 2A (step S16). Thereby, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, and the minute space 14 are formed.
- step S17 antennas 9, 11, and 12 are formed (step S17). Thereby, the detection element 10A is completed.
- FIG. 21 is another enlarged view of the inspection space 13 and the minute space 14 shown in FIG. In FIG. 21, only the portion of the cover member 1 that forms the inspection space 13 and the minute space 14 that forms the side walls 14A and 14B of the minute space 14 is shown.
- the cover member 2A may have only one protrusion 21.
- the vibrator 4 is disposed in the inspection space 13 and the minute space 14 so that the edge portion is located on one protrusion 21.
- the contact area between the vibrator 4 and the bottom surface 14 ⁇ / b> C of the minute space 14 becomes smaller than that without the projection 21, and the vibrator 4 vibrates more freely than without the projection 21. Therefore, free vibration of the vibrator 4 can be ensured.
- FIG. 22 is another enlarged view of the inspection space 13 and the minute space 14 shown in FIG. Also in FIG. 22, only the portion of the cover member 1 that forms the inspection space 13 and the minute space 14 that forms the side walls 14A and 14B of the minute space 14 is illustrated.
- the cover member 2 ⁇ / b> A may have two protrusions 21 and 24.
- the vibrator 4 is disposed in the inspection space 13 and the minute space 14 so that the edge portion is positioned on the two protrusions 21 and 24.
- the contact area between the vibrator 4 and the bottom surface 14 ⁇ / b> C of the minute space 14 is smaller than that without the projections 21 and 24, and the vibrator 4 vibrates more freely than without the projections 21 and 24. To do. Therefore, free vibration of the vibrator 4 can be ensured.
- the cover member 2A is not limited to the two protrusions 21 and 24, but includes two protrusions 21 and 22, two protrusions 22 and 23, two protrusions 21, 23, and two protrusions. Any one of the objects 22 and 24 and the two protrusions 23 and 24 may be provided. In this case, the contact area between the vibrator 4 and the bottom surface 14C of the minute space 14 is reduced, and the vibrator 4 vibrates more freely than when there are no protrusions 21, 22 or the like. Therefore, free vibration of the vibrator 4 can be ensured.
- the two protrusions are not limited to the arrangement positions and intervals shown in FIG. 22, but are arranged at arbitrary intervals on the bottom surface 14C of the micro space 14. Is done.
- FIG. 23 is another enlarged view of the inspection space 13 and the minute space 14 shown in FIG. In FIG. 23, only the portion of the cover member 1 that forms the inspection space 13 and the minute space 14 that forms the side walls 14A and 14B of the minute space 14 is shown.
- the cover member 2A may have three protrusions 21 to 23.
- the vibrator 4 is disposed in the inspection space 13 and the minute space 14 so that the edge portion is positioned on the three protrusions 21 to 23.
- the contact area between the vibrator 4 and the bottom surface 14C of the minute space 14 is smaller than that without the protrusions 21 to 23, and the vibrator 4 vibrates more freely than without the protrusions 21 to 23. To do. Therefore, free vibration of the vibrator 4 can be ensured.
- the cover member 2A is not limited to the three protrusions 21 to 23, but is any one of the three protrusions 22 to 243, the protrusions 21, 22, 24, and the three protrusions 21, 23, 24. You may have. In this case, the contact area between the vibrator 4 and the bottom surface 14C of the minute space 14 becomes small, and the vibrator 4 vibrates more freely than when there are no projections 22 to 24 and the like. Therefore, free vibration of the vibrator 4 can be ensured.
- the three protrusions are not limited to the arrangement positions and intervals shown in FIG. 23, and are arranged at arbitrary intervals on the bottom surface 14C of the micro space 14. Is done.
- the cover member 2A may have five or more protrusions, and generally has only m (m is a positive integer) protrusions. .
- the cover member 2A has three or more protrusions, the three or more protrusions can support the vibrator 4 horizontally.
- FIG. 24 is a schematic view of still another detection element according to the embodiment of the present invention.
- FIG. 25 is a plan view of the examination space 13 and the minute space 14 as viewed from the direction A shown in FIG. In FIG. 25, only the portions of the cover member 1A that form the inspection space 13 and the minute space 14 that form the side walls 14A and 14B of the minute space 14 are illustrated.
- the detection element according to the embodiment of the present invention may be the detection element 10B shown in FIGS. Referring to FIGS. 24 and 25, detection element 10B is obtained by replacing cover member 1 of detection element 10A shown in FIGS. 18 and 19 with cover member 1A, and is otherwise the same as detection element 10A. .
- the cover member 1A is joined to the cover member 2A in contact with the cover member 2A.
- the cover member 1A is made of the same material as the cover member 1 described above.
- the cover member 1A is the same as the cover member 1 except that support portions 25 to 32 are added to the cover member 1 described above.
- the support portions 25 to 32 are provided on the side walls 14A, 14B, 14D, and 14E of the micro space 14 so as to protrude from the micro space 14 toward the inspection space 13. More specifically, the support portions 25 and 32 are provided on the side wall 14A of the micro space 14, the support portions 26 and 27 are provided on the side wall 14D of the micro space 14, and the support portions 28 and 29 are provided on the micro space 14. The support portions 30 and 31 are provided on the side wall 14 ⁇ / b> E of the minute space 14. The support portions 25 to 32 are arranged in the vicinity of the four corners of the inspection space 13.
- Each of the support portions 25 to 32 has a semicircular cross-sectional shape.
- the cover member 1A is integrally formed so as to have the support portions 25-32.
- the vibrator 4 (indicated by a dotted line in FIG. 25) is arranged so that the edge portion is located on the projections 21 to 24 and the side surface is in contact with the support portions 25 to 32. In this case, the vibrator 4 makes point contact with the support portions 25 to 32.
- the contact area between the vibrator 4 and the cover members 1A and 2A is smaller than the contact area between the vibrator 4 and the cover member 2 in the detection element 10, and the vibrator 4 is smaller than the case of the detection element 10. Vibrates freely. Therefore, free vibration of the vibrator 4 can be ensured.
- the vibrator 4 is supported by the support portions 25 to 32 in the plane direction of the cover members 1A, 2A, and 3. As a result, the vibrator 4 is difficult to move in the in-plane direction of the cover members 1A, 2A, 3 even if the liquid to be inspected circulates in the inspection space 13 and the minute space 14. Therefore, the inspection object can be accurately detected even when the inspection target liquid is circulated.
- the support portions 25 to 32 are not limited to the vicinity of the four corners of the inspection space 13, but are provided at arbitrary intervals on the side walls 14A, 14B, 14D, and 14E of the minute space 14. It's okay.
- FIG. 26 is a process diagram showing a method of manufacturing the detection element 10B shown in FIGS. 24 and 25.
- the process diagram shown in FIG. 26 is the same as the process diagram shown in FIG. 20 except that step S11 in the process diagram shown in FIG. 20 is replaced with step S11A.
- support portions 25 to 32, recesses 101, and 101 are formed on one main surface of glass constituting cover member 1A using photolithography and etching in semiconductor technology. 102, 104, 105 and through holes 103, 106 are formed (step S11A).
- the resist coating, the resist patterning, and the etching are repeated in the order of shallowness to support the support.
- Portions 25 to 32, recesses 101, 102, 104, 105 and through holes 103, 106 are formed.
- the resist is patterned using a mask having a shape formed by the side walls 14A, 14B, 14D, and 14E of the minute space 14 shown in FIG.
- step S11A the above-described steps S12 to S17 are sequentially executed to complete the detection element 10B.
- the cover member 2A only needs to have m protrusions as described above.
- the arrangement positions and intervals of the m protrusions are arbitrary.
- the cover member 1A may include the support portions 27 to 30 among the support portions 25 to 32.
- the cover member 1A may have support portions 25, 26, 31, 32 among the support portions 25-32. This is because if there is a support portion on the downstream side when the liquid to be inspected flows through the inspection space 13, the vibrator 4 can be made difficult to move.
- the description of the other parts of the detection element 10B is the same as the description of the detection element 10A.
- FIG. 27 is a sectional view of still another detection element according to the embodiment of the present invention.
- FIG. 28 is a plan view of the examination space 13 and the minute space 14 as viewed from the direction A shown in FIG. In FIG. 28, only the portion of the cover member 2B that forms the inspection space 13 and the minute space 14 that forms the side walls 14A and 14B of the minute space 14 is illustrated.
- the detection element according to the embodiment of the present invention may be the detection element 10C shown in FIGS. Referring to FIGS. 27 and 28, detection element 10C is the same as detection element 10A except that cover member 2A of detection element 10A shown in FIG. 18 is replaced with cover member 2B.
- the cover member 2 ⁇ / b> B is disposed between the cover member 1 and the cover member 3 in contact with both the cover members 1 and 3.
- the cover member 2B is made of the same material as the cover member 2 described above.
- the cover member 2B is obtained by adding support portions 33 to 36 to the cover member 2A described above, and is otherwise the same as the cover member 2A.
- the support portions 33 to 36 are provided on the bottom side 14C of the micro space 14 on the corner side of the micro space 14 with respect to the protrusions 21 to 24, respectively. More specifically, the support portion 33 is provided on the corner portion side of the minute space 14 with respect to the protrusion 21, and the support portion 34 is provided on the corner portion side of the minute space 14 with respect to the protrusion 22. 35 is provided on the corner side of the minute space 14 with respect to the protrusion 23, and the support portion 36 is provided on the corner side of the minute space 14 with respect to the protrusion 24.
- Each of the support portions 33 to 36 has a quadrangular cross-sectional shape.
- the cover member 2B is integrally formed so as to have the protrusions 21 to 24 and the support portions 33 to 36.
- the vibrator 4 (indicated by a dotted line in FIG. 28) is arranged such that the edge portion is located on the protrusions 21 to 24 and the four corner portions are in contact with the support portions 33 to 36, respectively. In this case, the vibrator 4 makes point contact with the support portions 33 to 36.
- the contact area between the vibrator 4 and the cover member 2B is smaller than the contact area between the vibrator 4 and the cover member 2 in the detection element 10, and the vibrator 4 is freer than in the case of the detection element 10. Vibrate. Therefore, free vibration of the vibrator 4 can be ensured.
- the vibrator 4 is supported by the support portions 33 to 36 in the plane direction of the cover members 1, 2 B, 3. As a result, the vibrator 4 is difficult to move in the in-plane direction of the cover members 1, 2 ⁇ / b> B, 3 even if the liquid to be inspected circulates in the inspection space 13 and the minute space 14. Therefore, the inspection object can be accurately detected even when the inspection target liquid is circulated.
- FIG. 29 is a process diagram showing a method for manufacturing the detection element 10 ⁇ / b> C shown in FIGS. 27 and 28.
- the process diagram shown in FIG. 29 is the same as the process diagram shown in FIG. 20 except that step S12 in the process diagram shown in FIG. 20 is replaced with step S12A.
- step S11 when the manufacturing of detection element 10C is started, step S11 described above is executed, and cover member 1 is manufactured. Then, the projections 21 to 24, the support portions 33 to 36, and the through holes 201 and 203 to 206 are formed on the silicon constituting the cover member 2B by photolithography and etching (step S12A). Thereby, the cover member 2B is produced.
- the cover member 2B only needs to have m protrusions as described above.
- the arrangement positions and intervals of the m protrusions are arbitrary.
- the cover member 2B may include support portions 34 and 36 among the support portions 33 to 36, and the inspection target
- the cover member 1A may include support portions 33 and 35 among the support portions 33 to 36. This is because if there is a support portion on the downstream side when the liquid to be inspected flows through the inspection space 13, the vibrator 4 can be made difficult to move.
- the description of the other parts of the detection element 10C is the same as that of the detection element 10A.
- FIG. 30 is a diagram showing the results of a vibration test of the vibrator 4.
- the vertical axis represents amplitude
- the horizontal axis represents frequency.
- the solid line indicates the result of the vibration test of the vibrator 4 in the detection element 10A
- the circle indicates the result of the vibration test of the vibrator 4 when the periphery of the vibrator 4 is sandwiched.
- the amplitude of the vibration is remarkably larger than when the periphery of the vibrator 4 is sandwiched.
- FIG. 31 is a process diagram showing another method for manufacturing the detection element 10A shown in FIGS.
- recesses 101, 102, 104, 105, and the like are formed on one main surface of glass constituting cover member 1 using photolithography and etching in semiconductor technology.
- the through holes 103 and 106 are formed (step S21).
- the recesses 101, 102, 104, 105 and the through holes 103, 106 have different depths, the resist coating, the resist patterning, and the etching are repeated in the order of shallowness, and the recesses 101, 102, 104, 105 and through holes 103 and 106 are formed.
- projections 21 to 24 and through holes 201 and 203 to 206 are formed in the silicon constituting the cover member 2A by using photolithography and etching (step S22).
- resist coating, resist patterning, and etching are repeated to form the projections 21 to 24 and then the through holes 201 and 203 to 206 are formed.
- the cover member 2A is joined to the cover member 3 by anodic joining so that the protrusions 21 to 24 of the cover member 2A are located on the upper side (step S23).
- a sacrificial layer is applied on the cover member 2A (step S24).
- This sacrificial layer is made of, for example, polyimide whose trade name is HD-3007 (HD Micro Systems).
- step S25 the crystal plate is bonded to the sacrificial layer.
- step S26 the integrated member composed of the cover member 3 / cover member 2A / sacrificial layer / crystal plate is turned over so that the crystal plate is positioned on the lower side, and the crystal plate is polished to a desired thickness (step S26).
- step S27 the crystal plate after polishing is etched to produce the vibrator 4 (step S27).
- the cover member 1 is brought into contact with the cover member 2A so that the concave portions 101, 104 and the through holes 103, 106 of the cover member 1 face the through holes 201, 203-206 of the cover member 2A, and the cover member is subjected to the anodic bonding described above. 1 is joined to the cover member 2A (step S28). Thereby, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, and the inspection space 13 are formed.
- the sacrificial layer is removed by flowing the sacrificial layer removal solution into the inspection space 13 using the formed introduction port 5, introduction route 6, discharge route 7, and discharge port 8 (step S29).
- a minute space 14 is formed, and the edge of the vibrator 4 comes into contact with the protrusions 21 to 24 in the minute space 14.
- the sacrificial layer removal solution is made of, for example, EKC865 (Dupont EKC Technology).
- antennas 9, 11, and 12 are formed (step S30). Thereby, the detection element 10A is completed.
- step S24 may replace with above-mentioned step S24, S25, and may perform the process of apply
- the quartz plate is polished to a desired thickness after forming an integrated body composed of the cover member 3 / cover member 2A / sacrificial layer / quartz plate (see step S26).
- the thickness of the vibrator 4 can be made thinner than when the vibrator 4 is manufactured by polishing a quartz plate. As a result, the detection sensitivity for detecting the detection object can be improved.
- each of the detection elements 10, 10B, and 10C described above may be manufactured according to the process diagram shown in FIG. Further, when the detection elements 100, 100A, 100B, and 300 are manufactured, a process diagram shown in FIG. 31 may be used.
- FIG. 32 is a diagram showing another vibrator.
- the vibrator 4 may be a vibrator 4A (see FIG. 32A).
- the vibrator 4A has a substantially square shape and includes protrusions 41A and 42A.
- the protrusions 41A and 42A are respectively arranged on two opposite sides of the square. In the vibrator 4A, the two projecting portions 41A and 42A are inserted into the minute space 14.
- protrusions may be provided on four sides of the square.
- the vibrator 4 may be the vibrator 4B (see FIG. 32B).
- the vibrator 4B has a substantially circular shape.
- at least two opposite edge portions 41B and 43B are inserted into the micro space 14. Just do it.
- the vibrator 4 may have a polygonal shape such as a triangle, a quadrangle, a pentagon, and a hexagon other than that shown in FIG. When the vibrator 4 is formed of a polygon, at least two opposing edges of the vibrator 4 are inserted into the minute space 14.
- the antennas 9 and 11 may be disposed below the cover member 3, and the antenna 12 may be disposed above the cover member 1.
- all of the antennas 9, 11, and 12 may be disposed on one side of the vibrator 4.
- the antennas 9, 11, and 12 are arranged on one side of the vibrator 4 in the order of the antenna 9, the antenna 12, and the antenna 11 in one direction within one plane.
- the antennas 110 and 120 may be disposed below the unit elements 91 to 9n, and the antenna 130 may be disposed above the unit elements 91 to 9n.
- all of the antennas 110, 120, and 130 may be arranged on one side of the unit elements 91 to 9n.
- the antennas 110, 120, and 130 are arranged on one side of the unit elements 91 to 9n in the order of the antenna 110, the antenna 130, and the antenna 120 in one direction within one plane.
- the antennas 110 and 120 may be disposed on the lower surface 313A of the cover member 313, and the antenna 130 may be disposed on the upper surface 311A of the cover member 311.
- all of the antennas 110, 120, and 130 may be arranged on either one of the lower surface 313 A of the cover member 313 and the upper surface 311 A of the cover member 311.
- the antennas 110, 120, and 130 are either one of the lower surface 313A of the cover member 313 and the upper surface 311A of the cover member 311 in the order of the antenna 110, the antenna 130, and the antenna 120 in one direction within one plane. Placed on the side.
- the cover members 2 312 are made of silicon. However, in the embodiment of the present invention, the present invention is not limited to this, and the cover members 2 312 may be made of glass.
- the cover member 2 is bonded to the cover members 1 and 3 by either diffusion bonding or heat and pressure bonding.
- the cover member 312 is bonded to the cover members 311 and 313 by either diffusion bonding or heat and pressure bonding.
- the detection element 10 may include an introduction path 6 including only the introduction path 6b.
- Each of the unit elements 91 to 9n may include the introduction path 6 including only the introduction path 6b.
- the other end of the introduction path 6 b is connected to the introduction port 5.
- the cover members 1, 2A, 3 of the detection element 10A, the vibrator 4, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, the inspection space 13 and the minute space 14 Each of the unit elements 91 to 9n of the detection elements 100, 100A, and 100B may be manufactured by using the cover members 1A, 2A, and 3, the vibrator 4, the introduction port 5, the introduction path 6, and the discharge of the detection element 10B. Each of the unit elements 91 to 9n of the detection elements 100, 100A, and 100B may be manufactured by using the path 7, the discharge port 8, the inspection space 13, and the minute space 14, and the cover members 1, 2B, and 3 of the detection element 10C. Each of the unit elements 91 to 9n of the detection elements 100, 100A, and 100B using the vibrator 4, the introduction port 5, the introduction route 6, the discharge route 7, the discharge port 8, the inspection space 13, and the minute space 14. It may be produced.
- the detection element 300 may be manufactured using any of the detection elements 10A, 10B, and 10C.
- the detection elements 10, 10A, 10B, 10C, 100, 100A, 100B, and 300 may be used as gas sensors.
- the cover member 2B only needs to have two support portions (support portions 34 and 36 or support portions 33 and 35), so that the detection element according to the embodiment of the present invention can be used.
- the cover member should just have k (k is an integer greater than or equal to 2) support parts.
- the antenna 12 or the antenna 130 constitutes a “first antenna”
- the antenna 9 or the antenna 110 constitutes a “second antenna”
- the antenna 11 or the antenna 120 Constitutes a “third antenna”.
- the cover member 1 constitutes a “first cover member”
- the cover member 2 constitutes a “second cover member”
- the cover member 3 constitutes a “first cover member”. 3 cover member ".
- the cover member 140 or the cover member 160 constitutes an “auxiliary cover member”.
- the present invention is applied to a detection element using a vibrator.
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Abstract
Description
このように、共振周波数の変化量Δfは、振動子4の質量の変化量Δm、すなわち、検出対象物の質量に比例し、振動子4の質量mに反比例する。したがって、検出対象物の質量が大きくなる程、または振動子4の質量(=厚み)が小さくなる程、共振周波数fの変化量Δfが大きくなり、検出対象物の振動子4への付着を検知し易くなる。
Claims (14)
- 検査対象の液体が導入される検査空間と、前記検査空間に対して開口した微小空間とを内部に有するカバー部材と、
前記カバー部材に設けられ、前記液体を前記検査空間へ導入する導入経路と、
前記カバー部材に設けられ、前記液体を前記検査空間から排出する排出経路と、
前記検査空間に配置されるとともに、前記検査空間のサイズよりも大きいサイズを有し、前記微小空間内に挿入された縁部を有する振動子と、
接地電位に接続された第1のアンテナと、
前記第1のアンテナと協働して電磁場を前記振動子に印加する第2のアンテナと、
前記振動子が振動したときの振動信号からなる受信信号を前記第1のアンテナと協働して前記振動子から受信する第3のアンテナとを備える検出素子。 - 前記カバー部材は、
断面が略U字形状からなる第1の凹部と、前記第1の凹部の縁部から連続して設けられ、かつ、断面が略L字形状からなる第2の凹部とを一主面側に有する第1のカバー部材と、
前記第1の凹部と略同じサイズからなる貫通孔を有し、前記貫通孔が前記第1の凹部に向かい合い、かつ、前記貫通孔以外の部分が前記第1のカバー部材の前記一主面に接して配置されることにより前記微小空間を構成する第2のカバー部材と、
前記第2のカバー部材の前記第1のカバー部材に接する面と反対側の面に接して配置され、前記第1の凹部および前記貫通孔とともに前記検査空間を構成する第3のカバー部材とを含む、請求項1に記載の検出素子。 - 前記第1および第3のカバー部材は、ガラスからなり、
前記第2のカバー部材は、シリコンからなる、請求項2に記載の検出素子。 - 前記カバー部材は、前記微小空間内に挿入された前記振動子の縁部よりも下側に位置する前記微小空間の低面に形成されたm(mは正の整数)個の突起物を更に有し、
前記振動子の前記縁部は、前記m個の突起物上に配置されている、請求項1に記載の検出素子。 - 前記n個の突起物は、前記振動子を略水平に支持する3個以上の突起物からなる、請求項4に記載の検出素子。
- 前記カバー部材は、前記振動子の側面部の一部を支持するk(kは2以上の整数)個の支持部材を更に有する、請求項5に記載の検出素子。
- 各々が検査対象の液体が導入される複数の検査空間と、前記複数の検査空間に対応して設けられ、かつ、各々が対応する前記検査空間に対して開口した複数の微小空間とを内部に有するカバー部材と、
前記複数の検査空間に対応して前記カバー部材に設けられ、各々が対応する前記検査空間に前記液体を導入する複数の導入経路と、
前記複数の検査空間に対応して前記カバー部材に設けられ、各々が対応する前記検査空間から前記液体を排出する複数の排出経路と、
前記複数の検査空間に対応して設けられ、各々が、対応する前記検査空間に配置されるとともに、前記検査空間のサイズよりも大きいサイズを有し、前記微小空間内に挿入された縁部を有する複数の振動子と、
接地電位に接続された第1のアンテナと、
前記第1のアンテナと協働して電磁場を前記複数の振動子に印加する第2のアンテナと、
前記振動子が振動したときの振動信号からなる受信信号を前記第1のアンテナと協働して前記複数の振動子から受信する第3のアンテナとを備える検出素子。 - 前記カバー部材に接して配置され、複数の補助経路を有する補助カバー部材を更に備え、
前記複数の補助経路の各々は、隣接する2つの前記検査空間のうちの一方の検査空間に対応して設けられた前記排出経路と前記2つの検査空間のうちの他方の検査空間に対応して設けられた前記導入経路とを接続する、請求項7に記載の検出素子。 - 前記カバー部材に接して配置され、前記複数の検査空間に対応して設けられた複数の補助経路を有する補助カバー部材を更に備え、
前記複数の補助経路の各々は、対応する前記検査空間に対応して設けられた前記導入経路に前記液体を外部から導入する第1の補助経路と、対応する前記検査空間に対応して設けられた前記排出経路から前記液体を外部へ排出する第2の補助経路とからなる、請求項7に記載の検出素子。 - 複数のユニット素子と、
接地電位に接続された第1のアンテナと、
前記第1のアンテナと協働して電磁場を前記複数のユニット素子に含まれる複数の振動子に印加する第2のアンテナと、
前記振動子が振動したときの振動信号からなる受信信号を前記第1のアンテナと協働して前記複数の振動子から受信する第3のアンテナとを備え、
前記複数のユニット素子の各々は、
検査対象の液体が導入される検査空間と、前記検査空間に対して開口した微小空間とを内部に有するカバー部材と、
前記カバー部材に設けられ、前記液体を前記検査空間へ導入する導入経路と、
前記カバー部材に設けられ、前記液体を前記検査空間から排出する排出経路と、
前記検査空間に配置されるとともに、前記検査空間のサイズよりも大きいサイズを有し、前記微小空間内に挿入された縁部を有する振動子とを含む、検出素子。 - 前記複数のユニット素子に含まれる複数のカバー部材に接して配置され、各々が前記複数のユニット素子に含まれる複数の検査空間のうちの隣接する2つの検査空間を接続する複数の補助経路を有する補助カバー部材を更に備え、
前記複数の補助経路の各々は、前記2つの検査空間のうちの一方の検査空間に対応して設けられた前記排出経路と前記2つの検査空間のうちの他方の検査空間に対応して設けられた前記導入経路とを接続する、請求項10に記載の検出素子。 - 前記複数のユニット素子に含まれる複数のカバー部材に接して配置され、前記複数のユニット素子に含まれる複数の検査空間に対応して設けられた複数の補助経路を有する補助カバー部材を更に備え、
前記複数の補助経路の各々は、対応する前記検査空間に対応して設けられた前記導入経路に前記液体を外部から導入する第1の補助経路と、対応する前記検査空間に対応して設けられた前記排出経路から前記液体を外部へ排出する第2の補助経路とからなる、請求項11に記載の検出素子。 - 前記複数の振動子は、相互に略同じ厚みを有する、請求項7から請求項12のいずれか1項に記載の検出素子。
- 前記複数の振動子は、相互に異なる厚みを有する、請求項7から請求項12のいずれか1項に記載の検出素子。
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Publication number | Priority date | Publication date | Assignee | Title |
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JP2014002014A (ja) * | 2012-06-18 | 2014-01-09 | Osaka Univ | 振動検出素子およびそれを用いた検出素子 |
JP2014190713A (ja) * | 2013-03-26 | 2014-10-06 | Katsumi Narasaki | においセンサ装置 |
WO2019026456A1 (ja) * | 2017-08-01 | 2019-02-07 | 国立大学法人大阪大学 | 振動検出素子およびその製造方法 |
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US20120318052A1 (en) | 2012-12-20 |
JPWO2011121859A1 (ja) | 2013-07-04 |
JP4981998B2 (ja) | 2012-07-25 |
US8438912B2 (en) | 2013-05-14 |
SE535859C2 (sv) | 2013-01-15 |
SE1251087A1 (sv) | 2012-09-27 |
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