WO2011083563A1 - Support et dispositif de mesure photobiologique utilisant celui-ci - Google Patents

Support et dispositif de mesure photobiologique utilisant celui-ci Download PDF

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Publication number
WO2011083563A1
WO2011083563A1 PCT/JP2010/050014 JP2010050014W WO2011083563A1 WO 2011083563 A1 WO2011083563 A1 WO 2011083563A1 JP 2010050014 W JP2010050014 W JP 2010050014W WO 2011083563 A1 WO2011083563 A1 WO 2011083563A1
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WO
WIPO (PCT)
Prior art keywords
light
arm member
connecting portion
annular
probe
Prior art date
Application number
PCT/JP2010/050014
Other languages
English (en)
Japanese (ja)
Inventor
晴英 宇田川
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Priority to JP2011548878A priority Critical patent/JP5370497B2/ja
Priority to PCT/JP2010/050014 priority patent/WO2011083563A1/fr
Publication of WO2011083563A1 publication Critical patent/WO2011083563A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/706—Indicia not located on the patient, e.g. floor marking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms

Definitions

  • the present invention relates to a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.
  • an optical brain functional imaging apparatus (optical biometric apparatus) that performs simple noninvasive measurement using light has been developed.
  • near-infrared light of three different wavelengths ⁇ 1, ⁇ 2, and ⁇ 3 (for example, 780 nm, 805 nm, and 830 nm) is obtained by a light transmission probe disposed on the head surface of the subject.
  • the intensity (received light amount information) A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) of near-infrared light of each wavelength emitted from the brain by a light receiving probe arranged on the head surface. ) Are detected.
  • the concentration / optical path length product [oxyHb] of oxyhemoglobin in the cerebral blood flow and the concentration of deoxyhemoglobin are obtained.
  • the simultaneous equations shown in the relational expressions (1), (2), and (3) are created using the Modified Beer Lambert rule, and the simultaneous equations are solved ( For example, refer nonpatent literature 1).
  • concentration / optical path length product of total hemoglobin ([oxyHb] + [deoxyHb]) is calculated from the concentration / optical path length product [oxyHb] of oxyhemoglobin and the deoxyhemoglobin concentration / optical path length product [deoxyHb]. Yes.
  • a ( ⁇ 1) EO ( ⁇ 1) ⁇ [oxyHb] + Ed ( ⁇ 1) ⁇ [deoxyHb] (1)
  • a ( ⁇ 2) EO ( ⁇ 2) ⁇ [oxyHb] + Ed ( ⁇ 2) ⁇ [deoxyHb] (2)
  • a ( ⁇ 3) EO ( ⁇ 3) ⁇ [oxyHb] + Ed ( ⁇ 3) ⁇ [deoxyHb] (3)
  • EO ( ⁇ m) is an absorbance coefficient of oxyhemoglobin in light of wavelength ⁇ m
  • Ed ( ⁇ m) is an absorbance coefficient of deoxyhemoglobin in light of wavelength ⁇ m.
  • FIG. 9A is a cross-sectional view showing a relationship between a pair of light transmitting probe and light receiving probe and a measurement site
  • FIG. 9B is a plan view of FIG. 9A.
  • the light transmitting probe 12 is pressed against the light transmitting point T on the subject's head surface
  • the light receiving probe 13 is pressed against the light receiving point R on the subject's head surface. Then, light is emitted from the light transmitting probe 12 and light emitted from the head surface is incident on the light receiving probe 13.
  • the light that has passed through the banana shape (measurement region) among the light irradiated from the light transmission point T on the head surface reaches the light receiving point R on the head surface.
  • the light transmitting point T and the light receiving point R from the middle point M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the head surface of the subject in the measurement region.
  • Received light quantity information A ( ⁇ 1), A ( ⁇ 2) relating to the measurement site S of the subject having a depth L / 2 which is half the distance of the line connecting the shortest distance along the head surface of the subject. , A ( ⁇ 3) is obtained.
  • oxyhemoglobin concentration / optical path length product [oxyHb], deoxyhemoglobin concentration / optical path length product [deoxyHb], and total hemoglobin concentration / optical path length product for multiple measurement sites of the brain In order to measure [oxyHb] + [deoxyHb]), for example, a near-infrared spectrometer is used. In a near-infrared spectrometer, a holder is used to bring a light-transmitting probe and a light-receiving probe into contact with the subject's head surface in a predetermined arrangement.
  • the holder is provided with a plurality of through-holes, and by inserting the light-transmitting probe and the light-receiving probe into the through-holes, the probe interval between the light-transmitting probe and the light-receiving probe is constant, and a specific distance from the head surface
  • the received light amount information that is the depth is obtained.
  • the probe interval is called a channel, and in general, for adults, a channel with a channel of 30 mm is used.
  • the channel is 30 mm, the amount of light received at a depth of 15 mm to 20 mm from the midpoint of the channel Information is believed to be available. That is, the position at a depth of 15 mm to 20 mm from the head surface substantially corresponds to the brain surface region, and the received light quantity information A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) related to the brain activity is obtained.
  • FIG. 10 is a plan view showing the arrangement of a plurality of light transmitting probes and a plurality of light receiving probes.
  • Fifteen light transmitting probes (black circles) 12 and fifteen light receiving probes (white circles) 13 are arranged in a square lattice pattern so as to alternate in the row direction and the column direction. Then, light is emitted from the light transmitting probe 12, and the light receiving probe 13 adjacent to the light transmitting probe 12 that has emitted the light is detected to detect the light emitted from the head surface, thereby receiving light reception amount information A ( ⁇ 1), A ( ⁇ 2) and A ( ⁇ 3) are acquired. Accordingly, when viewed in plan as shown in FIG.
  • the measurement site (x mark) S is the midpoint between the light transmitting probe 12 and the light receiving probe 13 that receives light from the light transmitting probe 12, for a total of 49 pieces.
  • the received light amount information A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) is collected.
  • the light transmitting probe 12 and the light receiving probe 13 are assumed to be easily mountable even if there is a difference in curvature on the head surface.
  • the holding parts to be held are arranged in a square lattice pattern on the head surface, and the holding parts are connected by a connection part having a set distance (for example, 30 mm) that does not exhibit stretchability, and further within the contact surface of the head surface
  • a connection part having a set distance for example, 30 mm
  • the holder 111 includes 30 socket parts (holding parts) 133 for fixing the light transmitting probe 12 and the light receiving probe 13, 49 connection parts 131, and 30 nut parts 132.
  • FIG. 11 is an exploded perspective view showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133.
  • FIG. 12 is a diagram showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133 after being assembled.
  • the connection component 131 is a plate-shaped body having a single letter shape.
  • the connection component 131 includes annular insertion portions 131a at both ends, and connection portions 131b that connect the insertion portions 131a at both ends with a channel length X.
  • a circular through-hole for inserting the socket component 133 is opened at the center of each insertion portion 131a.
  • the connecting portion 131b has a width of 10 mm and a thickness of 0.1 mm, and is formed such that the distance between the center of the through hole and the center of the through hole is a channel length of 30 mm. Only flexible in the direction. That is, the insertion portions 131a at both ends are always held with a channel length of 30 mm.
  • the material constituting the connection component 131 is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the socket part 133 has a cylindrical body (for example, 15 mm in diameter) main body part 133a, an annular jaw part 133b, and an annular bottom part (contact mechanism) 133c.
  • the light receiving probe 13 can be inserted, and a screw (fixing mechanism) to which the nut part 132 is screwed is formed on the outer peripheral surface of the main body 133a.
  • the nut part 132 has an annular shape having a circular through hole, and a female screw to be screwed to the main body part 133a of the socket part 133 is formed on the inner peripheral surface thereof.
  • the size of the through hole is larger than the size of the main body portion 133a of the socket component 133 and smaller than the jaw portion 133b of the socket component 133 when viewed from above.
  • the insertion portion 131a of the connection part 131 is inserted between the jaw part 133b of the socket part 133 and the nut part 132 by inserting the main body part 133a of the socket part 133 into the nut part 132 using the screw mechanism. It can be pinched and fixed.
  • the light transmitting probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the socket component 133.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light emitting section (not shown) is fixed inside the light transmission probe 12 via a spring or the like, and the distal end portion of the light guide path The light comes to be irradiated from.
  • the light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the socket component 133.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light detection unit (not shown) is fixed inside the light receiving probe 13 via a spring or the like, and the tip of the light guide path The light is received from.
  • the holder 111 shown in FIG. 10 is assembled using 30 socket parts 133, 49 connection parts 131, and 30 nut parts 132. And in order to make such a holder 111 closely adhere to the subject's head surface, a measurer such as a doctor slightly loosens the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. As shown in FIG. 12 (a), one connecting component 131 and the other connecting component 131 as viewed from above form a desired angle with the socket component 133 as a rotation axis, and are shown in FIG. 12 (b).
  • connection part 131b of the connection component 131 has flexibility, it deform
  • the measurer securely fixes the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. Then, the holder 111 can no longer return to the flat surface, and the curvature is maintained. Finally, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement inside the socket component 133.
  • the measurer uses the one connecting component 131 and the other connecting component 131 to set the socket component 133 as the rotation axis and the desired angle.
  • the screw mechanism between the jaw part 133b of the socket part 133 and the nut part 132 is firmly fixed after being deformed so as to have a curvature that matches the head surface.
  • the screw mechanism between the jaw part 133b of the 30 socket parts 133 and the nut part 132 is firmly fixed.
  • the number of light transmitting probes 12 and light receiving probes 13 to be used increases, so that, for example, 100 socket parts 133 and nut parts 132 are provided.
  • the screw mechanism between the two was fixed firmly, which was very laborious for the measurer and took a long time for the subject, and was very stressful.
  • the present inventor does not need to adjust the screw mechanism between the socket part 133 and the nut part 132 and examines a holder that can be in close contact with a surface having various curvatures. Went. Therefore, as shown in FIG. 12 (a), the one connection component 131 and the other connection component 131 have the same effect as that formed by using the socket component 133 as a rotation axis when viewed from above.
  • an insertion member having a ring body (annular portion) having an annular shape and an arm member having a hook body (connecting portion) are produced, and an arbitrary member selected from all of the ring body is selected.
  • the ring body and the hook body are kept connected and the desired position (desired angle) of the ring body and the hook body are connected. It has been found that the arm member having the hook body can be moved. Also, as shown in FIG. 12 (b), since the connection portion 131b of the connection component 131 has flexibility, it is assumed that the ring body and the hook body are connected with each other as having the same effect. In the cross section, it has been found that the arm member having the hook body can be rotated about the ring body by rotating the cross section of the hook body with respect to the cross section of the ring body.
  • the holder of the present invention is a holder that holds a plurality of light-transmitting probes that irradiate light from the tip and a plurality of light-receiving probes that receive light from the tip and is mounted on the surface of the subject's head.
  • a plurality of insertion members having a single through-hole into which a light transmitting probe or a light receiving probe is inserted at a central portion, and connecting portions for connecting to the insertion members at both ends, the connecting portions being
  • a plurality of arm members formed so as to be separated from each other by a first set distance, and the insertion member is formed with an annular portion having a ring shape that is separated from the central axis of the through hole by a second set distance.
  • the annular part of the inserting member and the connecting part of the arm member And the insertion member while maintaining the connected state.
  • the arm member can move around the central axis of the through hole in the contact surface of the head surface so that a desired position of the annular portion and the connecting portion of the arm member are connected.
  • the connecting part of the arm member becomes an annular part in the normal direction of the head surface.
  • the “first setting distance” and the “second setting distance” are arbitrary distances determined in advance by a designer or the like, for example, the sum of the first setting distance and twice the second setting distance.
  • the distance is 30 mm or the like.
  • a predetermined number of insertion members having an annular portion and a predetermined number of arm members having coupling portions at both ends are provided.
  • the measurer or the like first uses a predetermined number of insertion members and a predetermined number of arm members to connect an arbitrary position of the annular portion of the insertion member and the connection portion of the arm member, Make a holder.
  • the measurer or the like brings the holder into close contact with the surface of the head of the subject, but the desired position of the annular portion of the insertion member and the connecting portion of the arm member are connected.
  • the arm member can move within the contact surface of the head surface, and the connecting portion of the arm member rotates with respect to the annular portion in the normal direction of the head surface. Since the arm member can be rotated in the normal direction, if the holder is mounted on the surface of the head of the subject, the holder has a curvature that matches the surface of the head of the subject.
  • the annular portion has an annular shape that is separated from the central axis of the through hole by a second set distance, if the annular portion of the insertion member and the connecting portion of the arm member are connected, one The distance between the central axis of the through-hole of the insertion member and the central axis of the through-hole of the other insertion member is substantially held at a total distance of the first set distance and twice the second set distance. . That is, if the total distance of the first set distance and twice the second set distance is, for example, 30 mm, the received light amount information A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) related to the brain activity is Obtainable.
  • the holder of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder can be in close contact with a surface having various curvatures.
  • the annular part is a ring body in which a cylindrical body or a polygonal column is an annular shape, and a part of the ring body is inserted inside the connection part of the arm member It may be a hook body having a semi-cylindrical body or a semi-polygonal tubular body.
  • the “semi-cylindrical body or semi-polygonal cylindrical body” refers to a cylindrical body or a polygonal cylindrical body that is partially cut off in the cross section.
  • the ring body is a ring body in which the columnar body has an annular shape, and the coupling part is a hook body having a semi-cylindrical body, so that the hook body is against the ring body. It can be smoothly rotated in the normal direction of the head surface.
  • the ring body is a ring body in which the polygonal column has an annular shape
  • the connection part is a hook body having a semi-polygonal cylindrical body, so that the hook body has a head relative to the ring body. It can be rotated stepwise in the normal direction of the part surface.
  • the connecting portion of the arm member is a sphere, a cylindrical body, or a polygonal column
  • the annular portion is a semi-cylindrical shape for inserting the connecting portion of the arm member or You may make it have a semi-polygonal cylindrical groove.
  • the “semi-cylindrical shape or semi-polygonal cylindrical shape” means a cylindrical shape or a polygonal cylindrical shape that is partially cut off in the cross section.
  • Examples include a semi-cylindrical body having a 270 ° annular shape with a part thereof cut off, and a regular hexagonal cylindrical body having a 200 ° regular hexagon in which a part of a 360 ° regular hexagon is missing in a cross section.
  • the connecting portion is a spherical body or a cylindrical body, and the annular portion has a semicylindrical groove. It can rotate smoothly in the linear direction.
  • the connecting part is a polygonal column, and the annular part has a semi-polygonal cylindrical groove so that the connecting part is normal to the surface of the head relative to the annular part. Can be rotated step by step.
  • a single through hole into which the light transmitting probe or the light receiving probe is inserted may be formed in the central portion of the arm member.
  • a single through hole into which the EEG electrode is inserted may be formed in the central portion of the arm member. According to the holder of the present invention, it is possible to measure an electrical signal at a measurement site measured using light.
  • the optical biometric apparatus of the present invention includes a holder as described above, a plurality of light transmitting probes that irradiate light from the tip, a plurality of light receiving probes that receive light from the tip, and the light transmitting probe and the light receiving probe. And a controller for controlling light transmission / reception.
  • FIG. 1 is a block diagram showing an example of a schematic configuration of an optical biometric apparatus according to an embodiment of the present invention.
  • FIG. 2 is a perspective view showing an example of a holder attached to a sphere having a diameter of 200 mm.
  • the optical biometric apparatus 1 includes a holder 11 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmission probe 12 and a light guide (not shown), a light receiving probe 13 and a light guide.
  • the optical detection unit 3 is connected by an optical path (not shown), the electrical detection unit 4 is connected to the EEG electrode 14, and a control unit (computer) 20 that controls the entire optical biometric apparatus 1.
  • the optical biometric apparatus 1 includes a holder 11 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmission probe 12 and a light guide (not shown), a light receiving probe 13 and a light guide.
  • the optical detection unit 3 is connected by an optical path (not shown), the electrical detection
  • FIG. 3 is a perspective view showing an example of the insertion member 33, the first arm member 31, and the second arm member 32.
  • FIG. 4 shows a plurality of the insertion members 33 and the plurality of first arm members 31 after being assembled. And a plurality of second arm members 32.
  • FIG. 5 is a perspective view showing an example of the light transmission probe 12.
  • the holder 11 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of first arm members 31 for connecting one insertion member 33 and the other insertion member 33, A plurality of second arm members 32 for connecting one insertion member 33 and another insertion member 33 are provided.
  • the insertion member 33 includes a main body 33a having a circular (for example, a diameter of 8 mm) through hole 33d at the center, an annular ring portion 33b, and a main body 33a. And four connecting portions 33c that connect the annular portion 33b.
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 33d. Thereby, if the light transmission probe 12 is inserted inside the through-hole 33d, the insertion member 33 and the light transmission probe 12 can be fixed.
  • the annular portion 33b is a ring body in which a cylindrical body (for example, a diameter of 1 mm) has an annular shape.
  • connection portion 33c connects the side surface of the main body portion 33a and the side surface of the annular portion 33b, and the four connection portions 33c are formed at positions of 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock in plan view.
  • a material which comprises the said insertion member For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
  • the first arm member 31 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 31 b in the center portion, and a connecting portion 31 a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 31b. Thereby, if the light transmission probe 12 is inserted inside the through hole 31b, the first arm member 31 and the light transmission probe 12 can be fixed.
  • the connecting portion 31a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm) with a part of a circular shape of 270 ° and a semi-cylindrical body with a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the first arm member 31 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body.
  • connection part 31a since it has the connection part 31a in both ends, if one connection part 31a and the one insertion member 33 are connected and another connection part 31a and the other insertion member 33 are connected, the one insertion member 33 will be described. And the other insertion member 33 can be connected.
  • the one connecting portion 31a and the other connecting portion 31a are formed so as to be separated by a first set distance (for example, 18.5 mm), the through hole 33d of the one insertion member 33 and the other insertion portion
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance.
  • the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is arcuate, the probe interval (linear distance) is, for example, 30.0 mm.
  • the cross-sections at all positions of the annular portion 33b have the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 31a are connected, the annular portion While maintaining the state where 33b and the connecting portion 31a are connected, the other portion (an angle within 360 °) of the annular portion 33b and the connecting portion 31a are connected.
  • the first arm member 31 is movable. That is, the first arm member 31 uses the central axis of the through-hole 33d as a rotation axis so that a desired position (desired angle) and the coupling portion 31a are coupled to each other from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 31a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 31a are connected.
  • the first arm member 31 can be rotated about two axes so that the central axis of the through-hole 33d is a rotation axis and the annular portion 33b is a rotation axis.
  • the material constituting the first arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the second arm member 32 is a plate-shaped body having a single letter shape, and has one large through hole 32b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through holes 32c having a diameter of 1.2 mm) are provided at the center, and the connecting portions 32a are provided at both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the EEG electrode 14 can be inserted inside the large through hole 32b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 32b, the second arm member 32 and the EEG electrode 14 can be fixed.
  • the connecting portion 32a is a hook body having a circular shape of 270 ° in which a part of a circular shape having a cross section of 360 ° (for example, a diameter of 1 mm) is missing and a semi-cylindrical body having a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the second arm member 32 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body.
  • connection part 32a since it has the connection part 32a in both ends, if one connection part 32a and the one insertion member 33 are connected and another connection part 32a and the other insertion member 33 are connected, the one insertion member 33 will be obtained. And the other insertion member 33 can be connected.
  • the one connecting portion 32a and the other connecting portion 32a are formed so as to be separated from each other by a first set distance (for example, 18.5 mm).
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance.
  • the light transmitting probe 12 is inserted into the through hole 33 d of one insertion member 33
  • the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 33
  • the EEG electrode is inserted into the through hole 32 b of the second arm member 32. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
  • the cross-sections at all positions of the annular portion 33b are the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 32a are connected, the annular portion While maintaining the state where 33b and the connecting portion 32a are connected, the other position (any angle of 360 °) of the annular portion 33b and the connecting portion 32a are connected.
  • the second arm member 32 is movable.
  • the second arm member 32 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 32a are connected from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 32a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 32a are connected.
  • the second arm member 32 is rotatable with the annular portion 33b as a rotation axis.
  • the second arm member 32 can be rotated about two axes so that the central axis of the through-hole 33d serves as a rotation axis and the annular portion 33b serves as a rotation axis.
  • the material constituting the second arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the light transmission probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the insertion member 33.
  • a light guide path (for example, a diameter of 1 mm) such as an optical fiber connected to the light emitting section 2 is fixed inside the light transmission probe 12 via a spring or the like, and light is irradiated from the tip of the light guide path. It has come to be.
  • the light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the insertion member 33.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to the light detection unit 3 is fixed inside the light receiving probe 13 via a spring or the like, and light is received from the tip of the light guide path. It is supposed to be.
  • the EEG electrode 14 has a cylindrical shape (for example, the EEG electrode 14) that can be fixed to the central portion (one large through hole 32 b and eight small through holes 32 c) of the second arm member 32. The outer diameter is 11 mm). An electric signal is received from the lower end of the EEG electrode 14.
  • the holder 11 shown in FIG. 2 is assembled using the plurality of insertion members 33, the plurality of first arm members 31, and the plurality of second arm members 32. At this time, a total of four arm members 31, 32 are placed at arbitrary positions on the annular portion 33 b of one insertion member 33 so that the first arm member 31 and the second arm member 32 alternate. Link. Then, when the measurer puts such a holder 11 on the surface of the head of the subject, the holder 11 has a desired position of the annular portion 33b of the insertion member 33 and the connecting portion 31a of the first arm member 31. In the contact surface of the head surface so that the desired position of the annular portion 33b of the insertion member 33 and the connection portion 32a of the second arm member 32 are connected.
  • the connecting portion 31a of the first arm member 31 rotates relative to the annular portion 33b of the insertion member 33 in the normal direction of the head surface.
  • the first arm member 31 rotates in the normal direction of the head surface, and the connecting portion 32a of the second arm member 32 in relation to the annular portion 33b of the insertion member 33 in the normal direction of the head surface.
  • the second arm member 3 in the direction normal to the head surface There is rotated. That is, the holder 11 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject.
  • the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 33d of the insertion member 33, and inserts the EEG electrode 14 into the large through hole 32b of the second arm member 32. To do.
  • the light-emitting unit 2 is a light source that transmits light to one light-transmitting probe 12 selected from among a plurality of light-transmitting probes 12 according to a drive signal input from the computer 20, for example, an LED (light-emitting diode). And a light emitting element such as an LD (laser diode). Near-infrared light (for example, 780 nm, 805 nm, and 830 nm) is used as the light.
  • the light detection unit 3 is a detector that outputs a plurality of light reception signals to the computer 20 by individually detecting near-infrared light received by the plurality of light reception probes 13, such as a photodiode or a phototransistor. A light receiving element, a photomultiplier tube, and the like.
  • the electric detector 4 is a detector that outputs a plurality of electric signals to the computer 20 by individually detecting electric signals received by the plurality of EEG electrodes 14, and is, for example, an electroencephalograph.
  • the computer 20 includes a CPU 21, and further includes a memory 50, a display device 23 having a monitor screen 23a and the like, and a keyboard 22a and a mouse 22b as input devices.
  • the function processed by the CPU 21 will be described as a block.
  • the light transmitting / receiving unit control unit 40 that controls the light emitting unit 2 and the light detection unit 3, the calculation unit 41, the EEG electrode control unit 45 that controls the EEG electrode 14, and the brain And an activity image display control unit 44.
  • the light transmission / reception unit control unit 40 receives light reception signals from the light emission control unit 42 that outputs a drive signal to the light emission unit 2 and the light detection unit 3, and stores light reception signals (light reception amount information) in the memory 50.
  • a control unit 43 is a control unit 43.
  • the light emission control unit 42 performs control to output a drive signal for sequentially transmitting light to the light transmission probe 12 to the light emitting unit 2.
  • the light detection control unit 43 receives the light reception signals from the light detection unit 3, thereby storing a plurality of measurement data A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) detected from the plurality of light reception probes 13 in the memory 50. Control to be stored in
  • the EEG electrode control unit 45 performs control to store the plurality of measurement data B detected from the plurality of EEG electrodes 14 in the memory 50 by receiving the electric signal from the electric detector unit 4.
  • the calculation unit 41 uses the measurement data A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) stored in the memory 50 to measure the measurement data A from the light transmission probe 12 to the light reception probe 13 adjacent to the light transmission probe 12.
  • the brain activity image display control unit 44 performs control to display information on the monitor screen 23a. For example, a contour graph of oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration on the brain plane is displayed.
  • the holder 11 used in the photobiological measuring device 1 of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. be able to. Moreover, the electrical signal in the measurement site
  • the optical biometric apparatus includes a holder 60 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3 and the control part (computer) 20 which performs control of the whole optical biometric apparatus. In addition, the same code
  • FIG. The parts constituting the holder 60 will be described. 6A is a perspective view showing an example of the third arm member 34, and FIG. 6B is a view showing the plurality of insertion members 33 and the plurality of third arm members 34 after being assembled. is there.
  • the holder 60 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, and a plurality of third arm members 34 for connecting one insertion member 33 and the other insertion member 33.
  • the third arm member 34 is a letter-shaped plate-like body, and has a connecting portion 34a at both ends so as to be separated by a first set distance (for example, 3.5 mm).
  • the connecting portion 34a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm), a 270 ° circular shape with a part missing, and a semi-cylindrical body with a height of 3 mm. is there.
  • the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion.
  • the third arm member 34 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semicylindrical body. Further, since the connecting portions 34a are provided at both ends, if one connecting portion 34a and one insertion member 33 are connected and another connecting portion 34a and another insertion member 33 are connected, one inserting member 33 is provided. And the other insertion member 33 can be connected. At this time, since the one connecting portion 34a and the other connecting portion 34a are formed so as to be separated by a first set distance (for example, 3.5 mm), the through hole 33d of the one insertion member 33 and the other insertion are inserted.
  • a first set distance for example, 3.5 mm
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 16.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmitting probe 12 is inserted into the through hole 33d of one insertion member 33 and the light receiving probe 13 is inserted into the through hole 33d of the other insertion member 33 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 16.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 15.0 mm.
  • the third arm member 34 is movable. That is, the third arm member 34 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 34a are connected from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 34a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 34a are connected.
  • the third arm member 34 can be rotated about two axes so that the central axis of the through-hole 33d becomes a rotation axis and the annular portion 33b becomes a rotation axis.
  • the material constituting the third arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • a holder 60 shown in FIG. 6B is assembled.
  • a total of four third arm members 34 are connected to any position of the annular portion 33 b of one insertion member 33.
  • the holder 60 connects the desired position of the annular portion 33b of the insertion member 33 and the connecting portion 34a of the third arm member 34.
  • the third arm member 34 rotates within the contact surface of the head surface so that the connection portion 34a of the third arm member 34 is inserted in the normal direction of the head surface.
  • the third arm member 34 rotates in the normal direction of the head surface so as to rotate with respect to the annular portion 33b of 33. That is, the holder 60 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 into the through hole 33d of the insertion member 33 in a predetermined arrangement.
  • the holder 60 used in the photobiological measurement device of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder 60 is in close contact with a surface having various curvatures. Can do.
  • the optical biometric apparatus includes a holder 70 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3, the electric detection part 4 connected with the EEG electrode 14, and the control part (computer) 20 which performs control of the whole optical biometric apparatus.
  • symbol is attached
  • FIG. The parts constituting the holder 70 will be described.
  • FIG. 7 is a perspective view showing an example of the insertion member 73, the fourth arm member 71, and the fifth arm member 72.
  • the holder 70 includes a plurality of insertion members 73 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of fourth arm members 71 for connecting the one insertion member 73 and the other insertion member 73, and one A plurality of fifth arm members 72 for connecting the insertion member 73 and another insertion member 73 are provided.
  • the insertion member 73 includes a main body 73a having a circular (for example, diameter of 8 mm) through-hole 73d at the center, and an annular ring portion 73b.
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 73d.
  • the annular portion 73b is formed by forming a 270 ° semi-cylindrical groove (for example, 2 mm in diameter) in a ring shape on a side surface of the main body portion 73a.
  • a semi-cylindrical groove is formed so that a portion lacking on the outside is disposed. Further, the annular portion 73b is formed so as to be separated from the central axis of the through hole 73d by a second set distance (for example, 6.5 mm).
  • a second set distance for example, 6.5 mm.
  • a material which comprises the said insertion member For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
  • the fourth arm member 71 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 71b in the center portion, and a connecting portion 71a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 71b. Thereby, if the light transmission probe 12 is inserted inside the through hole 71b, the fourth arm member 71 and the light transmission probe 12 can be fixed.
  • the connecting portion 71a is a sphere (for example, a diameter of 2 mm).
  • the connecting portion 71a can be inserted into an arbitrary position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 71a is inserted in the annular part 73b, the 4th arm member 71 and the insertion member 73 can be connected now. Moreover, since it has the connection part 71a at both ends, if one connection part 71a and the one insertion member 73 are connected and another connection part 71a and the other insertion member 73 are connected, the one insertion member 73 is connected. And the other insertion member 73 can be connected.
  • the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted.
  • the distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmission probe 12 is inserted into the through hole 73d of one insertion member 73 and the light receiving probe 13 is inserted into the through hole 73d of the other insertion member 73 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 30.0 mm.
  • the cross section of the internal space of the annular portion 73b has the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 71a are connected, the annular portion 73b. While maintaining the state where the connecting portion 71a and the connecting portion 71a are connected, the other position (any angle of 360 °) of the annular portion 73b and the connecting portion 71a are connected to each other.
  • the four arm members 71 are movable. That is, the fourth arm member 71 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 71a are connected from all the portions of the annular portion 73b. Is movable.
  • the connecting portion 71a is in the cross-section in the cross-section while maintaining the state where the arbitrary position of the annular portion 73b and the connecting portion 71a are connected.
  • the fourth arm member 71 can be rotated with the annular portion 73b as a rotation axis.
  • the fourth arm member 71 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
  • the material constituting the fourth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the fifth arm member 72 is a plate-shaped body having a single letter shape, and has one large through-hole 72b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through-holes 72c having a diameter of 1.2 mm) are provided at the center, and connecting portions 72a are provided at both ends so as to be separated by a first set distance (for example, a diameter of 18.5 mm).
  • the EEG electrode 14 can be inserted inside the large through hole 72b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 72b, the fifth arm member 72 and the EEG electrode 14 can be fixed.
  • the connecting portion 72a is a sphere (for example, a diameter of 2 mm).
  • the connecting portion 72a can be inserted into any position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 72a is inserted in the annular part 73b, the 5th arm member 72 and the insertion member 73 can be connected. Moreover, since it has the connection part 72a in both ends, if one connection part 72a and the one insertion member 73 are connected and another connection part 72a and the other insertion member 73 are connected, the one insertion member 73 will be obtained. And the other insertion member 73 can be connected.
  • the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted.
  • the distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, the light transmitting probe 12 is inserted into the through hole 73 d of one insertion member 73, the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 73, and the EEG electrode is inserted into the through hole 72 b of the fifth arm member 72. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
  • the cross section of the internal space of the annular portion 73b has the same circular shape, when the arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 72a are connected, the annular portion 73b. While maintaining the state where the connecting portion 72a is connected, the other position (any angle within 360 °) of the annular portion 73b and the connecting portion 72a are connected to each other.
  • the five arm members 72 are movable. That is, the fifth arm member 72 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 72a are connected from all the portions of the annular portion 73b. Is movable.
  • connection part 72a is in the cross section in the cross section while maintaining the state where the arbitrary position of the ring part 73b and the connection part 72a are connected.
  • the fifth arm member 72 can be rotated with the annular portion 73b as a rotation axis.
  • the fourth arm member 72 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
  • the material constituting the fifth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the holder 70 shown in FIG. 8 is assembled using such a plurality of insertion members 73, a plurality of fourth arm members 71, and a plurality of fifth arm members 72. At this time, a total of four arm members 71, 72 are placed at arbitrary positions on the annular portion 73 b of one insertion member 73 so that the fourth arm member 71 and the fifth arm member 72 alternate. Link. Then, when the measurer puts such a holder 70 on the surface of the head of the subject, the holder 70 is connected to a desired position of the annular portion 73b of the insertion member 73 and the connecting portion 71a of the fourth arm member 71.
  • the holder 70 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 73d of the insertion member 73, and inserts the EEG electrode 14 into the large through hole 72b of the fifth arm member 72. To do.
  • the holder 70 used in the photobiological measuring device of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. Can do. Moreover, the electrical signal in the measurement site
  • the annular portion 33b is a ring body having a circular cylindrical body, and the connecting portions 31a and 32a are hook bodies having a semi-cylindrical body.
  • the annular portion may be a ring body in which a polygonal column is an annular shape, and the connecting portion 32a may be a hook body having a semi-polygonal cylinder.
  • the annular portion 73b is configured such that a semi-cylindrical groove is formed in an annular shape, and the connecting portions 71a and 72a are spherical.
  • the annular portion may be configured such that a semi-polygonal cylindrical groove is formed in an annular shape, and the connecting portion may be a polygonal column.
  • the present invention can be used for a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.

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Abstract

La présente invention concerne un support (11) qui est caractérisé en ce que le support (11) est pourvu d'éléments d'insertion (33) et d'éléments de bras (31, 32) formés de sorte que des parties de raccordement (31a, 32a) soient séparées par une première distance définie, les éléments d'insertion (33) ont une partie annulaire (33b) séparée de l'axe central d'un trou de passage (33d) par une deuxième distance définie et ayant une forme annulaire, les éléments de bras (31, 32) peuvent être déplacés sur une surface de contact de la surface de tête de sorte que les positions souhaitées des parties annulaires (33b) des éléments d'insertion (33) soient raccordées aux parties de raccordement (31a, 32a) des éléments de bras (31, 32) lorsque des positions données parmi l'ensemble des parties des parties annulaires (33b) des éléments d'insertion (33) sont raccordées aux parties de raccordement (31a, 32a) des éléments de bras (31, 32), et en ce que les éléments de bras (31, 32) peuvent être tournés dans la direction normale de la surface de tête lorsque les parties de raccordement (31a, 32a) tournent par rapport aux parties annulaires (33b) dans la direction normale de la surface de tête pendant que l'état raccordé entre les positions souhaitées des parties annulaires (33b) des éléments d'insertion (33) et les parties de raccordement (31a, 32a) des éléments de bras (31, 32) est maintenu.
PCT/JP2010/050014 2010-01-05 2010-01-05 Support et dispositif de mesure photobiologique utilisant celui-ci WO2011083563A1 (fr)

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US11607132B2 (en) 2020-03-20 2023-03-21 Hi Llc Temporal resolution control for temporal point spread function generation in an optical measurement system
US11645483B2 (en) 2020-03-20 2023-05-09 Hi Llc Phase lock loop circuit based adjustment of a measurement time window in an optical measurement system
US11771362B2 (en) 2020-02-21 2023-10-03 Hi Llc Integrated detector assemblies for a wearable module of an optical measurement system
WO2023187054A1 (fr) 2022-03-31 2023-10-05 Gowerlabs Limited Module de guidage de lumière et appareil de mesure d'une propriété optique d'un milieu
US11819311B2 (en) 2020-03-20 2023-11-21 Hi Llc Maintaining consistent photodetector sensitivity in an optical measurement system
US11857348B2 (en) 2020-03-20 2024-01-02 Hi Llc Techniques for determining a timing uncertainty of a component of an optical measurement system
US11864867B2 (en) 2020-03-20 2024-01-09 Hi Llc Control circuit for a light source in an optical measurement system by applying voltage with a first polarity to start an emission of a light pulse and applying voltage with a second polarity to stop the emission of the light pulse
US11877825B2 (en) 2020-03-20 2024-01-23 Hi Llc Device enumeration in an optical measurement system
US11883181B2 (en) 2020-02-21 2024-01-30 Hi Llc Multimodal wearable measurement systems and methods
US11903676B2 (en) 2020-03-20 2024-02-20 Hi Llc Photodetector calibration of an optical measurement system
US11950879B2 (en) 2020-02-21 2024-04-09 Hi Llc Estimation of source-detector separation in an optical measurement system
US11969259B2 (en) 2020-02-21 2024-04-30 Hi Llc Detector assemblies for a wearable module of an optical measurement system and including spring-loaded light-receiving members

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JP2009045479A (ja) * 2003-04-02 2009-03-05 Shimadzu Corp 光生体測定装置及びホルダー
WO2005058161A1 (fr) * 2003-12-16 2005-06-30 Hitachi Medical Corporation Sonde photometrique biologique
JP2007203080A (ja) * 2007-02-05 2007-08-16 Hitachi Ltd 光計測装置、および光ファイバー保持装置

Cited By (18)

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JPWO2015033440A1 (ja) * 2013-09-06 2017-03-02 株式会社島津製作所 脳機能計測装置および脳機能計測装置用プローブホルダ
US11867911B2 (en) 2020-02-21 2024-01-09 Hi Llc Wearable devices and wearable assemblies with adjustable positioning for use in an optical measurement system
WO2021167892A1 (fr) * 2020-02-21 2021-08-26 Hi Llc Dispositifs et ensembles portables avec positionnement réglable destinés à être utilisés dans un système de mesure optique
US11969259B2 (en) 2020-02-21 2024-04-30 Hi Llc Detector assemblies for a wearable module of an optical measurement system and including spring-loaded light-receiving members
US11950879B2 (en) 2020-02-21 2024-04-09 Hi Llc Estimation of source-detector separation in an optical measurement system
US11883181B2 (en) 2020-02-21 2024-01-30 Hi Llc Multimodal wearable measurement systems and methods
US11630310B2 (en) 2020-02-21 2023-04-18 Hi Llc Wearable devices and wearable assemblies with adjustable positioning for use in an optical measurement system
US11771362B2 (en) 2020-02-21 2023-10-03 Hi Llc Integrated detector assemblies for a wearable module of an optical measurement system
US11864867B2 (en) 2020-03-20 2024-01-09 Hi Llc Control circuit for a light source in an optical measurement system by applying voltage with a first polarity to start an emission of a light pulse and applying voltage with a second polarity to stop the emission of the light pulse
US11819311B2 (en) 2020-03-20 2023-11-21 Hi Llc Maintaining consistent photodetector sensitivity in an optical measurement system
US11857348B2 (en) 2020-03-20 2024-01-02 Hi Llc Techniques for determining a timing uncertainty of a component of an optical measurement system
US11645483B2 (en) 2020-03-20 2023-05-09 Hi Llc Phase lock loop circuit based adjustment of a measurement time window in an optical measurement system
US11877825B2 (en) 2020-03-20 2024-01-23 Hi Llc Device enumeration in an optical measurement system
US11607132B2 (en) 2020-03-20 2023-03-21 Hi Llc Temporal resolution control for temporal point spread function generation in an optical measurement system
US11903676B2 (en) 2020-03-20 2024-02-20 Hi Llc Photodetector calibration of an optical measurement system
US11245404B2 (en) 2020-03-20 2022-02-08 Hi Llc Phase lock loop circuit based signal generation in an optical measurement system
US11187575B2 (en) 2020-03-20 2021-11-30 Hi Llc High density optical measurement systems with minimal number of light sources
WO2023187054A1 (fr) 2022-03-31 2023-10-05 Gowerlabs Limited Module de guidage de lumière et appareil de mesure d'une propriété optique d'un milieu

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