WO2011083563A1 - Holder and photobiological measuring device using same - Google Patents

Holder and photobiological measuring device using same Download PDF

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Publication number
WO2011083563A1
WO2011083563A1 PCT/JP2010/050014 JP2010050014W WO2011083563A1 WO 2011083563 A1 WO2011083563 A1 WO 2011083563A1 JP 2010050014 W JP2010050014 W JP 2010050014W WO 2011083563 A1 WO2011083563 A1 WO 2011083563A1
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WO
WIPO (PCT)
Prior art keywords
light
arm member
connecting portion
annular
probe
Prior art date
Application number
PCT/JP2010/050014
Other languages
French (fr)
Japanese (ja)
Inventor
晴英 宇田川
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Priority to PCT/JP2010/050014 priority Critical patent/WO2011083563A1/en
Priority to JP2011548878A priority patent/JP5370497B2/en
Publication of WO2011083563A1 publication Critical patent/WO2011083563A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/70Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/706Indicia not located on the patient, e.g. floor marking
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50Supports for surgical instruments, e.g. articulated arms

Definitions

  • the present invention relates to a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.
  • an optical brain functional imaging apparatus (optical biometric apparatus) that performs simple noninvasive measurement using light has been developed.
  • near-infrared light of three different wavelengths ⁇ 1, ⁇ 2, and ⁇ 3 (for example, 780 nm, 805 nm, and 830 nm) is obtained by a light transmission probe disposed on the head surface of the subject.
  • the intensity (received light amount information) A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) of near-infrared light of each wavelength emitted from the brain by a light receiving probe arranged on the head surface. ) Are detected.
  • the concentration / optical path length product [oxyHb] of oxyhemoglobin in the cerebral blood flow and the concentration of deoxyhemoglobin are obtained.
  • the simultaneous equations shown in the relational expressions (1), (2), and (3) are created using the Modified Beer Lambert rule, and the simultaneous equations are solved ( For example, refer nonpatent literature 1).
  • concentration / optical path length product of total hemoglobin ([oxyHb] + [deoxyHb]) is calculated from the concentration / optical path length product [oxyHb] of oxyhemoglobin and the deoxyhemoglobin concentration / optical path length product [deoxyHb]. Yes.
  • a ( ⁇ 1) EO ( ⁇ 1) ⁇ [oxyHb] + Ed ( ⁇ 1) ⁇ [deoxyHb] (1)
  • a ( ⁇ 2) EO ( ⁇ 2) ⁇ [oxyHb] + Ed ( ⁇ 2) ⁇ [deoxyHb] (2)
  • a ( ⁇ 3) EO ( ⁇ 3) ⁇ [oxyHb] + Ed ( ⁇ 3) ⁇ [deoxyHb] (3)
  • EO ( ⁇ m) is an absorbance coefficient of oxyhemoglobin in light of wavelength ⁇ m
  • Ed ( ⁇ m) is an absorbance coefficient of deoxyhemoglobin in light of wavelength ⁇ m.
  • FIG. 9A is a cross-sectional view showing a relationship between a pair of light transmitting probe and light receiving probe and a measurement site
  • FIG. 9B is a plan view of FIG. 9A.
  • the light transmitting probe 12 is pressed against the light transmitting point T on the subject's head surface
  • the light receiving probe 13 is pressed against the light receiving point R on the subject's head surface. Then, light is emitted from the light transmitting probe 12 and light emitted from the head surface is incident on the light receiving probe 13.
  • the light that has passed through the banana shape (measurement region) among the light irradiated from the light transmission point T on the head surface reaches the light receiving point R on the head surface.
  • the light transmitting point T and the light receiving point R from the middle point M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the head surface of the subject in the measurement region.
  • Received light quantity information A ( ⁇ 1), A ( ⁇ 2) relating to the measurement site S of the subject having a depth L / 2 which is half the distance of the line connecting the shortest distance along the head surface of the subject. , A ( ⁇ 3) is obtained.
  • oxyhemoglobin concentration / optical path length product [oxyHb], deoxyhemoglobin concentration / optical path length product [deoxyHb], and total hemoglobin concentration / optical path length product for multiple measurement sites of the brain In order to measure [oxyHb] + [deoxyHb]), for example, a near-infrared spectrometer is used. In a near-infrared spectrometer, a holder is used to bring a light-transmitting probe and a light-receiving probe into contact with the subject's head surface in a predetermined arrangement.
  • the holder is provided with a plurality of through-holes, and by inserting the light-transmitting probe and the light-receiving probe into the through-holes, the probe interval between the light-transmitting probe and the light-receiving probe is constant, and a specific distance from the head surface
  • the received light amount information that is the depth is obtained.
  • the probe interval is called a channel, and in general, for adults, a channel with a channel of 30 mm is used.
  • the channel is 30 mm, the amount of light received at a depth of 15 mm to 20 mm from the midpoint of the channel Information is believed to be available. That is, the position at a depth of 15 mm to 20 mm from the head surface substantially corresponds to the brain surface region, and the received light quantity information A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) related to the brain activity is obtained.
  • FIG. 10 is a plan view showing the arrangement of a plurality of light transmitting probes and a plurality of light receiving probes.
  • Fifteen light transmitting probes (black circles) 12 and fifteen light receiving probes (white circles) 13 are arranged in a square lattice pattern so as to alternate in the row direction and the column direction. Then, light is emitted from the light transmitting probe 12, and the light receiving probe 13 adjacent to the light transmitting probe 12 that has emitted the light is detected to detect the light emitted from the head surface, thereby receiving light reception amount information A ( ⁇ 1), A ( ⁇ 2) and A ( ⁇ 3) are acquired. Accordingly, when viewed in plan as shown in FIG.
  • the measurement site (x mark) S is the midpoint between the light transmitting probe 12 and the light receiving probe 13 that receives light from the light transmitting probe 12, for a total of 49 pieces.
  • the received light amount information A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) is collected.
  • the light transmitting probe 12 and the light receiving probe 13 are assumed to be easily mountable even if there is a difference in curvature on the head surface.
  • the holding parts to be held are arranged in a square lattice pattern on the head surface, and the holding parts are connected by a connection part having a set distance (for example, 30 mm) that does not exhibit stretchability, and further within the contact surface of the head surface
  • a connection part having a set distance for example, 30 mm
  • the holder 111 includes 30 socket parts (holding parts) 133 for fixing the light transmitting probe 12 and the light receiving probe 13, 49 connection parts 131, and 30 nut parts 132.
  • FIG. 11 is an exploded perspective view showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133.
  • FIG. 12 is a diagram showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133 after being assembled.
  • the connection component 131 is a plate-shaped body having a single letter shape.
  • the connection component 131 includes annular insertion portions 131a at both ends, and connection portions 131b that connect the insertion portions 131a at both ends with a channel length X.
  • a circular through-hole for inserting the socket component 133 is opened at the center of each insertion portion 131a.
  • the connecting portion 131b has a width of 10 mm and a thickness of 0.1 mm, and is formed such that the distance between the center of the through hole and the center of the through hole is a channel length of 30 mm. Only flexible in the direction. That is, the insertion portions 131a at both ends are always held with a channel length of 30 mm.
  • the material constituting the connection component 131 is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the socket part 133 has a cylindrical body (for example, 15 mm in diameter) main body part 133a, an annular jaw part 133b, and an annular bottom part (contact mechanism) 133c.
  • the light receiving probe 13 can be inserted, and a screw (fixing mechanism) to which the nut part 132 is screwed is formed on the outer peripheral surface of the main body 133a.
  • the nut part 132 has an annular shape having a circular through hole, and a female screw to be screwed to the main body part 133a of the socket part 133 is formed on the inner peripheral surface thereof.
  • the size of the through hole is larger than the size of the main body portion 133a of the socket component 133 and smaller than the jaw portion 133b of the socket component 133 when viewed from above.
  • the insertion portion 131a of the connection part 131 is inserted between the jaw part 133b of the socket part 133 and the nut part 132 by inserting the main body part 133a of the socket part 133 into the nut part 132 using the screw mechanism. It can be pinched and fixed.
  • the light transmitting probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the socket component 133.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light emitting section (not shown) is fixed inside the light transmission probe 12 via a spring or the like, and the distal end portion of the light guide path The light comes to be irradiated from.
  • the light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the socket component 133.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light detection unit (not shown) is fixed inside the light receiving probe 13 via a spring or the like, and the tip of the light guide path The light is received from.
  • the holder 111 shown in FIG. 10 is assembled using 30 socket parts 133, 49 connection parts 131, and 30 nut parts 132. And in order to make such a holder 111 closely adhere to the subject's head surface, a measurer such as a doctor slightly loosens the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. As shown in FIG. 12 (a), one connecting component 131 and the other connecting component 131 as viewed from above form a desired angle with the socket component 133 as a rotation axis, and are shown in FIG. 12 (b).
  • connection part 131b of the connection component 131 has flexibility, it deform
  • the measurer securely fixes the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. Then, the holder 111 can no longer return to the flat surface, and the curvature is maintained. Finally, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement inside the socket component 133.
  • the measurer uses the one connecting component 131 and the other connecting component 131 to set the socket component 133 as the rotation axis and the desired angle.
  • the screw mechanism between the jaw part 133b of the socket part 133 and the nut part 132 is firmly fixed after being deformed so as to have a curvature that matches the head surface.
  • the screw mechanism between the jaw part 133b of the 30 socket parts 133 and the nut part 132 is firmly fixed.
  • the number of light transmitting probes 12 and light receiving probes 13 to be used increases, so that, for example, 100 socket parts 133 and nut parts 132 are provided.
  • the screw mechanism between the two was fixed firmly, which was very laborious for the measurer and took a long time for the subject, and was very stressful.
  • the present inventor does not need to adjust the screw mechanism between the socket part 133 and the nut part 132 and examines a holder that can be in close contact with a surface having various curvatures. Went. Therefore, as shown in FIG. 12 (a), the one connection component 131 and the other connection component 131 have the same effect as that formed by using the socket component 133 as a rotation axis when viewed from above.
  • an insertion member having a ring body (annular portion) having an annular shape and an arm member having a hook body (connecting portion) are produced, and an arbitrary member selected from all of the ring body is selected.
  • the ring body and the hook body are kept connected and the desired position (desired angle) of the ring body and the hook body are connected. It has been found that the arm member having the hook body can be moved. Also, as shown in FIG. 12 (b), since the connection portion 131b of the connection component 131 has flexibility, it is assumed that the ring body and the hook body are connected with each other as having the same effect. In the cross section, it has been found that the arm member having the hook body can be rotated about the ring body by rotating the cross section of the hook body with respect to the cross section of the ring body.
  • the holder of the present invention is a holder that holds a plurality of light-transmitting probes that irradiate light from the tip and a plurality of light-receiving probes that receive light from the tip and is mounted on the surface of the subject's head.
  • a plurality of insertion members having a single through-hole into which a light transmitting probe or a light receiving probe is inserted at a central portion, and connecting portions for connecting to the insertion members at both ends, the connecting portions being
  • a plurality of arm members formed so as to be separated from each other by a first set distance, and the insertion member is formed with an annular portion having a ring shape that is separated from the central axis of the through hole by a second set distance.
  • the annular part of the inserting member and the connecting part of the arm member And the insertion member while maintaining the connected state.
  • the arm member can move around the central axis of the through hole in the contact surface of the head surface so that a desired position of the annular portion and the connecting portion of the arm member are connected.
  • the connecting part of the arm member becomes an annular part in the normal direction of the head surface.
  • the “first setting distance” and the “second setting distance” are arbitrary distances determined in advance by a designer or the like, for example, the sum of the first setting distance and twice the second setting distance.
  • the distance is 30 mm or the like.
  • a predetermined number of insertion members having an annular portion and a predetermined number of arm members having coupling portions at both ends are provided.
  • the measurer or the like first uses a predetermined number of insertion members and a predetermined number of arm members to connect an arbitrary position of the annular portion of the insertion member and the connection portion of the arm member, Make a holder.
  • the measurer or the like brings the holder into close contact with the surface of the head of the subject, but the desired position of the annular portion of the insertion member and the connecting portion of the arm member are connected.
  • the arm member can move within the contact surface of the head surface, and the connecting portion of the arm member rotates with respect to the annular portion in the normal direction of the head surface. Since the arm member can be rotated in the normal direction, if the holder is mounted on the surface of the head of the subject, the holder has a curvature that matches the surface of the head of the subject.
  • the annular portion has an annular shape that is separated from the central axis of the through hole by a second set distance, if the annular portion of the insertion member and the connecting portion of the arm member are connected, one The distance between the central axis of the through-hole of the insertion member and the central axis of the through-hole of the other insertion member is substantially held at a total distance of the first set distance and twice the second set distance. . That is, if the total distance of the first set distance and twice the second set distance is, for example, 30 mm, the received light amount information A ( ⁇ 1), A ( ⁇ 2), A ( ⁇ 3) related to the brain activity is Obtainable.
  • the holder of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder can be in close contact with a surface having various curvatures.
  • the annular part is a ring body in which a cylindrical body or a polygonal column is an annular shape, and a part of the ring body is inserted inside the connection part of the arm member It may be a hook body having a semi-cylindrical body or a semi-polygonal tubular body.
  • the “semi-cylindrical body or semi-polygonal cylindrical body” refers to a cylindrical body or a polygonal cylindrical body that is partially cut off in the cross section.
  • the ring body is a ring body in which the columnar body has an annular shape, and the coupling part is a hook body having a semi-cylindrical body, so that the hook body is against the ring body. It can be smoothly rotated in the normal direction of the head surface.
  • the ring body is a ring body in which the polygonal column has an annular shape
  • the connection part is a hook body having a semi-polygonal cylindrical body, so that the hook body has a head relative to the ring body. It can be rotated stepwise in the normal direction of the part surface.
  • the connecting portion of the arm member is a sphere, a cylindrical body, or a polygonal column
  • the annular portion is a semi-cylindrical shape for inserting the connecting portion of the arm member or You may make it have a semi-polygonal cylindrical groove.
  • the “semi-cylindrical shape or semi-polygonal cylindrical shape” means a cylindrical shape or a polygonal cylindrical shape that is partially cut off in the cross section.
  • Examples include a semi-cylindrical body having a 270 ° annular shape with a part thereof cut off, and a regular hexagonal cylindrical body having a 200 ° regular hexagon in which a part of a 360 ° regular hexagon is missing in a cross section.
  • the connecting portion is a spherical body or a cylindrical body, and the annular portion has a semicylindrical groove. It can rotate smoothly in the linear direction.
  • the connecting part is a polygonal column, and the annular part has a semi-polygonal cylindrical groove so that the connecting part is normal to the surface of the head relative to the annular part. Can be rotated step by step.
  • a single through hole into which the light transmitting probe or the light receiving probe is inserted may be formed in the central portion of the arm member.
  • a single through hole into which the EEG electrode is inserted may be formed in the central portion of the arm member. According to the holder of the present invention, it is possible to measure an electrical signal at a measurement site measured using light.
  • the optical biometric apparatus of the present invention includes a holder as described above, a plurality of light transmitting probes that irradiate light from the tip, a plurality of light receiving probes that receive light from the tip, and the light transmitting probe and the light receiving probe. And a controller for controlling light transmission / reception.
  • FIG. 1 is a block diagram showing an example of a schematic configuration of an optical biometric apparatus according to an embodiment of the present invention.
  • FIG. 2 is a perspective view showing an example of a holder attached to a sphere having a diameter of 200 mm.
  • the optical biometric apparatus 1 includes a holder 11 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmission probe 12 and a light guide (not shown), a light receiving probe 13 and a light guide.
  • the optical detection unit 3 is connected by an optical path (not shown), the electrical detection unit 4 is connected to the EEG electrode 14, and a control unit (computer) 20 that controls the entire optical biometric apparatus 1.
  • the optical biometric apparatus 1 includes a holder 11 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmission probe 12 and a light guide (not shown), a light receiving probe 13 and a light guide.
  • the optical detection unit 3 is connected by an optical path (not shown), the electrical detection
  • FIG. 3 is a perspective view showing an example of the insertion member 33, the first arm member 31, and the second arm member 32.
  • FIG. 4 shows a plurality of the insertion members 33 and the plurality of first arm members 31 after being assembled. And a plurality of second arm members 32.
  • FIG. 5 is a perspective view showing an example of the light transmission probe 12.
  • the holder 11 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of first arm members 31 for connecting one insertion member 33 and the other insertion member 33, A plurality of second arm members 32 for connecting one insertion member 33 and another insertion member 33 are provided.
  • the insertion member 33 includes a main body 33a having a circular (for example, a diameter of 8 mm) through hole 33d at the center, an annular ring portion 33b, and a main body 33a. And four connecting portions 33c that connect the annular portion 33b.
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 33d. Thereby, if the light transmission probe 12 is inserted inside the through-hole 33d, the insertion member 33 and the light transmission probe 12 can be fixed.
  • the annular portion 33b is a ring body in which a cylindrical body (for example, a diameter of 1 mm) has an annular shape.
  • connection portion 33c connects the side surface of the main body portion 33a and the side surface of the annular portion 33b, and the four connection portions 33c are formed at positions of 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock in plan view.
  • a material which comprises the said insertion member For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
  • the first arm member 31 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 31 b in the center portion, and a connecting portion 31 a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 31b. Thereby, if the light transmission probe 12 is inserted inside the through hole 31b, the first arm member 31 and the light transmission probe 12 can be fixed.
  • the connecting portion 31a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm) with a part of a circular shape of 270 ° and a semi-cylindrical body with a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the first arm member 31 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body.
  • connection part 31a since it has the connection part 31a in both ends, if one connection part 31a and the one insertion member 33 are connected and another connection part 31a and the other insertion member 33 are connected, the one insertion member 33 will be described. And the other insertion member 33 can be connected.
  • the one connecting portion 31a and the other connecting portion 31a are formed so as to be separated by a first set distance (for example, 18.5 mm), the through hole 33d of the one insertion member 33 and the other insertion portion
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance.
  • the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is arcuate, the probe interval (linear distance) is, for example, 30.0 mm.
  • the cross-sections at all positions of the annular portion 33b have the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 31a are connected, the annular portion While maintaining the state where 33b and the connecting portion 31a are connected, the other portion (an angle within 360 °) of the annular portion 33b and the connecting portion 31a are connected.
  • the first arm member 31 is movable. That is, the first arm member 31 uses the central axis of the through-hole 33d as a rotation axis so that a desired position (desired angle) and the coupling portion 31a are coupled to each other from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 31a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 31a are connected.
  • the first arm member 31 can be rotated about two axes so that the central axis of the through-hole 33d is a rotation axis and the annular portion 33b is a rotation axis.
  • the material constituting the first arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the second arm member 32 is a plate-shaped body having a single letter shape, and has one large through hole 32b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through holes 32c having a diameter of 1.2 mm) are provided at the center, and the connecting portions 32a are provided at both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the EEG electrode 14 can be inserted inside the large through hole 32b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 32b, the second arm member 32 and the EEG electrode 14 can be fixed.
  • the connecting portion 32a is a hook body having a circular shape of 270 ° in which a part of a circular shape having a cross section of 360 ° (for example, a diameter of 1 mm) is missing and a semi-cylindrical body having a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the second arm member 32 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body.
  • connection part 32a since it has the connection part 32a in both ends, if one connection part 32a and the one insertion member 33 are connected and another connection part 32a and the other insertion member 33 are connected, the one insertion member 33 will be obtained. And the other insertion member 33 can be connected.
  • the one connecting portion 32a and the other connecting portion 32a are formed so as to be separated from each other by a first set distance (for example, 18.5 mm).
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance.
  • the light transmitting probe 12 is inserted into the through hole 33 d of one insertion member 33
  • the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 33
  • the EEG electrode is inserted into the through hole 32 b of the second arm member 32. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
  • the cross-sections at all positions of the annular portion 33b are the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 32a are connected, the annular portion While maintaining the state where 33b and the connecting portion 32a are connected, the other position (any angle of 360 °) of the annular portion 33b and the connecting portion 32a are connected.
  • the second arm member 32 is movable.
  • the second arm member 32 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 32a are connected from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 32a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 32a are connected.
  • the second arm member 32 is rotatable with the annular portion 33b as a rotation axis.
  • the second arm member 32 can be rotated about two axes so that the central axis of the through-hole 33d serves as a rotation axis and the annular portion 33b serves as a rotation axis.
  • the material constituting the second arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the light transmission probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the insertion member 33.
  • a light guide path (for example, a diameter of 1 mm) such as an optical fiber connected to the light emitting section 2 is fixed inside the light transmission probe 12 via a spring or the like, and light is irradiated from the tip of the light guide path. It has come to be.
  • the light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the insertion member 33.
  • a light guide path (for example, 1 mm in diameter) such as an optical fiber connected to the light detection unit 3 is fixed inside the light receiving probe 13 via a spring or the like, and light is received from the tip of the light guide path. It is supposed to be.
  • the EEG electrode 14 has a cylindrical shape (for example, the EEG electrode 14) that can be fixed to the central portion (one large through hole 32 b and eight small through holes 32 c) of the second arm member 32. The outer diameter is 11 mm). An electric signal is received from the lower end of the EEG electrode 14.
  • the holder 11 shown in FIG. 2 is assembled using the plurality of insertion members 33, the plurality of first arm members 31, and the plurality of second arm members 32. At this time, a total of four arm members 31, 32 are placed at arbitrary positions on the annular portion 33 b of one insertion member 33 so that the first arm member 31 and the second arm member 32 alternate. Link. Then, when the measurer puts such a holder 11 on the surface of the head of the subject, the holder 11 has a desired position of the annular portion 33b of the insertion member 33 and the connecting portion 31a of the first arm member 31. In the contact surface of the head surface so that the desired position of the annular portion 33b of the insertion member 33 and the connection portion 32a of the second arm member 32 are connected.
  • the connecting portion 31a of the first arm member 31 rotates relative to the annular portion 33b of the insertion member 33 in the normal direction of the head surface.
  • the first arm member 31 rotates in the normal direction of the head surface, and the connecting portion 32a of the second arm member 32 in relation to the annular portion 33b of the insertion member 33 in the normal direction of the head surface.
  • the second arm member 3 in the direction normal to the head surface There is rotated. That is, the holder 11 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject.
  • the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 33d of the insertion member 33, and inserts the EEG electrode 14 into the large through hole 32b of the second arm member 32. To do.
  • the light-emitting unit 2 is a light source that transmits light to one light-transmitting probe 12 selected from among a plurality of light-transmitting probes 12 according to a drive signal input from the computer 20, for example, an LED (light-emitting diode). And a light emitting element such as an LD (laser diode). Near-infrared light (for example, 780 nm, 805 nm, and 830 nm) is used as the light.
  • the light detection unit 3 is a detector that outputs a plurality of light reception signals to the computer 20 by individually detecting near-infrared light received by the plurality of light reception probes 13, such as a photodiode or a phototransistor. A light receiving element, a photomultiplier tube, and the like.
  • the electric detector 4 is a detector that outputs a plurality of electric signals to the computer 20 by individually detecting electric signals received by the plurality of EEG electrodes 14, and is, for example, an electroencephalograph.
  • the computer 20 includes a CPU 21, and further includes a memory 50, a display device 23 having a monitor screen 23a and the like, and a keyboard 22a and a mouse 22b as input devices.
  • the function processed by the CPU 21 will be described as a block.
  • the light transmitting / receiving unit control unit 40 that controls the light emitting unit 2 and the light detection unit 3, the calculation unit 41, the EEG electrode control unit 45 that controls the EEG electrode 14, and the brain And an activity image display control unit 44.
  • the light transmission / reception unit control unit 40 receives light reception signals from the light emission control unit 42 that outputs a drive signal to the light emission unit 2 and the light detection unit 3, and stores light reception signals (light reception amount information) in the memory 50.
  • a control unit 43 is a control unit 43.
  • the light emission control unit 42 performs control to output a drive signal for sequentially transmitting light to the light transmission probe 12 to the light emitting unit 2.
  • the light detection control unit 43 receives the light reception signals from the light detection unit 3, thereby storing a plurality of measurement data A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) detected from the plurality of light reception probes 13 in the memory 50. Control to be stored in
  • the EEG electrode control unit 45 performs control to store the plurality of measurement data B detected from the plurality of EEG electrodes 14 in the memory 50 by receiving the electric signal from the electric detector unit 4.
  • the calculation unit 41 uses the measurement data A ( ⁇ 1), A ( ⁇ 2), and A ( ⁇ 3) stored in the memory 50 to measure the measurement data A from the light transmission probe 12 to the light reception probe 13 adjacent to the light transmission probe 12.
  • the brain activity image display control unit 44 performs control to display information on the monitor screen 23a. For example, a contour graph of oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration on the brain plane is displayed.
  • the holder 11 used in the photobiological measuring device 1 of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. be able to. Moreover, the electrical signal in the measurement site
  • the optical biometric apparatus includes a holder 60 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3 and the control part (computer) 20 which performs control of the whole optical biometric apparatus. In addition, the same code
  • FIG. The parts constituting the holder 60 will be described. 6A is a perspective view showing an example of the third arm member 34, and FIG. 6B is a view showing the plurality of insertion members 33 and the plurality of third arm members 34 after being assembled. is there.
  • the holder 60 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, and a plurality of third arm members 34 for connecting one insertion member 33 and the other insertion member 33.
  • the third arm member 34 is a letter-shaped plate-like body, and has a connecting portion 34a at both ends so as to be separated by a first set distance (for example, 3.5 mm).
  • the connecting portion 34a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm), a 270 ° circular shape with a part missing, and a semi-cylindrical body with a height of 3 mm. is there.
  • the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion.
  • the third arm member 34 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semicylindrical body. Further, since the connecting portions 34a are provided at both ends, if one connecting portion 34a and one insertion member 33 are connected and another connecting portion 34a and another insertion member 33 are connected, one inserting member 33 is provided. And the other insertion member 33 can be connected. At this time, since the one connecting portion 34a and the other connecting portion 34a are formed so as to be separated by a first set distance (for example, 3.5 mm), the through hole 33d of the one insertion member 33 and the other insertion are inserted.
  • a first set distance for example, 3.5 mm
  • the distance between the member 33 and the through hole 33d is a total distance (for example, 16.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmitting probe 12 is inserted into the through hole 33d of one insertion member 33 and the light receiving probe 13 is inserted into the through hole 33d of the other insertion member 33 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 16.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 15.0 mm.
  • the third arm member 34 is movable. That is, the third arm member 34 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 34a are connected from all the portions of the annular portion 33b. Is movable.
  • the connecting portion 34a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 34a are connected.
  • the third arm member 34 can be rotated about two axes so that the central axis of the through-hole 33d becomes a rotation axis and the annular portion 33b becomes a rotation axis.
  • the material constituting the third arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • a holder 60 shown in FIG. 6B is assembled.
  • a total of four third arm members 34 are connected to any position of the annular portion 33 b of one insertion member 33.
  • the holder 60 connects the desired position of the annular portion 33b of the insertion member 33 and the connecting portion 34a of the third arm member 34.
  • the third arm member 34 rotates within the contact surface of the head surface so that the connection portion 34a of the third arm member 34 is inserted in the normal direction of the head surface.
  • the third arm member 34 rotates in the normal direction of the head surface so as to rotate with respect to the annular portion 33b of 33. That is, the holder 60 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 into the through hole 33d of the insertion member 33 in a predetermined arrangement.
  • the holder 60 used in the photobiological measurement device of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder 60 is in close contact with a surface having various curvatures. Can do.
  • the optical biometric apparatus includes a holder 70 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3, the electric detection part 4 connected with the EEG electrode 14, and the control part (computer) 20 which performs control of the whole optical biometric apparatus.
  • symbol is attached
  • FIG. The parts constituting the holder 70 will be described.
  • FIG. 7 is a perspective view showing an example of the insertion member 73, the fourth arm member 71, and the fifth arm member 72.
  • the holder 70 includes a plurality of insertion members 73 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of fourth arm members 71 for connecting the one insertion member 73 and the other insertion member 73, and one A plurality of fifth arm members 72 for connecting the insertion member 73 and another insertion member 73 are provided.
  • the insertion member 73 includes a main body 73a having a circular (for example, diameter of 8 mm) through-hole 73d at the center, and an annular ring portion 73b.
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 73d.
  • the annular portion 73b is formed by forming a 270 ° semi-cylindrical groove (for example, 2 mm in diameter) in a ring shape on a side surface of the main body portion 73a.
  • a semi-cylindrical groove is formed so that a portion lacking on the outside is disposed. Further, the annular portion 73b is formed so as to be separated from the central axis of the through hole 73d by a second set distance (for example, 6.5 mm).
  • a second set distance for example, 6.5 mm.
  • a material which comprises the said insertion member For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
  • the fourth arm member 71 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 71b in the center portion, and a connecting portion 71a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
  • the light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 71b. Thereby, if the light transmission probe 12 is inserted inside the through hole 71b, the fourth arm member 71 and the light transmission probe 12 can be fixed.
  • the connecting portion 71a is a sphere (for example, a diameter of 2 mm).
  • the connecting portion 71a can be inserted into an arbitrary position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 71a is inserted in the annular part 73b, the 4th arm member 71 and the insertion member 73 can be connected now. Moreover, since it has the connection part 71a at both ends, if one connection part 71a and the one insertion member 73 are connected and another connection part 71a and the other insertion member 73 are connected, the one insertion member 73 is connected. And the other insertion member 73 can be connected.
  • the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted.
  • the distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmission probe 12 is inserted into the through hole 73d of one insertion member 73 and the light receiving probe 13 is inserted into the through hole 73d of the other insertion member 73 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 30.0 mm.
  • the cross section of the internal space of the annular portion 73b has the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 71a are connected, the annular portion 73b. While maintaining the state where the connecting portion 71a and the connecting portion 71a are connected, the other position (any angle of 360 °) of the annular portion 73b and the connecting portion 71a are connected to each other.
  • the four arm members 71 are movable. That is, the fourth arm member 71 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 71a are connected from all the portions of the annular portion 73b. Is movable.
  • the connecting portion 71a is in the cross-section in the cross-section while maintaining the state where the arbitrary position of the annular portion 73b and the connecting portion 71a are connected.
  • the fourth arm member 71 can be rotated with the annular portion 73b as a rotation axis.
  • the fourth arm member 71 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
  • the material constituting the fourth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the fifth arm member 72 is a plate-shaped body having a single letter shape, and has one large through-hole 72b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through-holes 72c having a diameter of 1.2 mm) are provided at the center, and connecting portions 72a are provided at both ends so as to be separated by a first set distance (for example, a diameter of 18.5 mm).
  • the EEG electrode 14 can be inserted inside the large through hole 72b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 72b, the fifth arm member 72 and the EEG electrode 14 can be fixed.
  • the connecting portion 72a is a sphere (for example, a diameter of 2 mm).
  • the connecting portion 72a can be inserted into any position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 72a is inserted in the annular part 73b, the 5th arm member 72 and the insertion member 73 can be connected. Moreover, since it has the connection part 72a in both ends, if one connection part 72a and the one insertion member 73 are connected and another connection part 72a and the other insertion member 73 are connected, the one insertion member 73 will be obtained. And the other insertion member 73 can be connected.
  • the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted.
  • the distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, the light transmitting probe 12 is inserted into the through hole 73 d of one insertion member 73, the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 73, and the EEG electrode is inserted into the through hole 72 b of the fifth arm member 72. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
  • the cross section of the internal space of the annular portion 73b has the same circular shape, when the arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 72a are connected, the annular portion 73b. While maintaining the state where the connecting portion 72a is connected, the other position (any angle within 360 °) of the annular portion 73b and the connecting portion 72a are connected to each other.
  • the five arm members 72 are movable. That is, the fifth arm member 72 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 72a are connected from all the portions of the annular portion 73b. Is movable.
  • connection part 72a is in the cross section in the cross section while maintaining the state where the arbitrary position of the ring part 73b and the connection part 72a are connected.
  • the fifth arm member 72 can be rotated with the annular portion 73b as a rotation axis.
  • the fourth arm member 72 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
  • the material constituting the fifth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
  • the holder 70 shown in FIG. 8 is assembled using such a plurality of insertion members 73, a plurality of fourth arm members 71, and a plurality of fifth arm members 72. At this time, a total of four arm members 71, 72 are placed at arbitrary positions on the annular portion 73 b of one insertion member 73 so that the fourth arm member 71 and the fifth arm member 72 alternate. Link. Then, when the measurer puts such a holder 70 on the surface of the head of the subject, the holder 70 is connected to a desired position of the annular portion 73b of the insertion member 73 and the connecting portion 71a of the fourth arm member 71.
  • the holder 70 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 73d of the insertion member 73, and inserts the EEG electrode 14 into the large through hole 72b of the fifth arm member 72. To do.
  • the holder 70 used in the photobiological measuring device of the present invention it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. Can do. Moreover, the electrical signal in the measurement site
  • the annular portion 33b is a ring body having a circular cylindrical body, and the connecting portions 31a and 32a are hook bodies having a semi-cylindrical body.
  • the annular portion may be a ring body in which a polygonal column is an annular shape, and the connecting portion 32a may be a hook body having a semi-polygonal cylinder.
  • the annular portion 73b is configured such that a semi-cylindrical groove is formed in an annular shape, and the connecting portions 71a and 72a are spherical.
  • the annular portion may be configured such that a semi-polygonal cylindrical groove is formed in an annular shape, and the connecting portion may be a polygonal column.
  • the present invention can be used for a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.

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Abstract

A holder (11) is characterized in that the holder (11) is provided with insertion members (33) and arm members (31, 32) formed so that connection parts (31a, 32a) are separated by a first set distance, the insertion members (33) have an annular part (33b) separated from the center axis of a through hole (33d) by a second set distance and having an annular shape, the arm members (31, 32) can be moved on a contact surface of the head surface so that desired positions of the annular parts (33b) of the insertion members (33) are connected to the connection parts (31a, 32a) of the arm members (31, 32) when given positions among the whole parts of the annular parts (33b) of the insertion members (33) are connected to the connection parts (31a, 32a) of the arm members (31, 32), and in that the arm members (31, 32) can be rotated in the normal direction of the head surface when the connection parts (31a, 32a) rotate with respect to the annular parts (33b) in the normal direction of the head surface while the connected state between the desired positions of the annular parts (33b) of the insertion members (33) and the connection parts (31a, 32a) of the arm members (31, 32) is maintained.

Description

ホルダ及びこれを用いる光生体測定装置Holder and optical biometric apparatus using the same
 本発明は、光を用いて非侵襲で脳活動を測定するためのホルダ及びこれを用いる光生体測定装置に関する。 The present invention relates to a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.
 近年、脳の活動状況を観察するために、光を用いて簡便に非侵襲で測定する光脳機能イメージング装置(光生体測定装置)が開発されている。このような光脳機能イメージング装置では、被検者の頭部表面上に配置した送光プローブにより、異なる3種類の波長λ1、λ2、λ3(例えば、780nmと805nmと830nm)の近赤外光を脳に照射するとともに、頭部表面上に配置した受光プローブにより、脳から放出された各波長の近赤外光の強度(受光量情報)A(λ1)、A(λ2)、A(λ3)をそれぞれ検出する。
 そして、このようにして得られた受光量情報A(λ1)、A(λ2)、A(λ3)から、脳血流中のオキシヘモグロビンの濃度・光路長積[oxyHb]と、デオキシヘモグロビンの濃度・光路長積[deoxyHb]とを求めるために、例えば、Modified Beer Lambert則を用いて関係式(1)(2)(3)に示す連立方程式を作成して、この連立方程式を解いている(例えば、非特許文献1参照)。さらには、オキシヘモグロビンの濃度・光路長積[oxyHb]と、デオキシヘモグロビンの濃度・光路長積[deoxyHb]とから総ヘモグロビンの濃度・光路長積([oxyHb]+[deoxyHb])を算出している。
A(λ1)=EO(λ1)×[oxyHb]+Ed(λ1)×[deoxyHb] …(1)
A(λ2)=EO(λ2)×[oxyHb]+Ed(λ2)×[deoxyHb] …(2)
A(λ3)=EO(λ3)×[oxyHb]+Ed(λ3)×[deoxyHb] …(3)
 なお、EO(λm)は、波長λmの光におけるオキシヘモグロビンの吸光度係数であり、Ed(λm)は、波長λmの光におけるデオキシヘモグロビンの吸光度係数である。
In recent years, in order to observe the activity state of the brain, an optical brain functional imaging apparatus (optical biometric apparatus) that performs simple noninvasive measurement using light has been developed. In such an optical brain functional imaging apparatus, near-infrared light of three different wavelengths λ1, λ2, and λ3 (for example, 780 nm, 805 nm, and 830 nm) is obtained by a light transmission probe disposed on the head surface of the subject. Is irradiated to the brain, and the intensity (received light amount information) A (λ1), A (λ2), A (λ3) of near-infrared light of each wavelength emitted from the brain by a light receiving probe arranged on the head surface. ) Are detected.
Then, from the received light quantity information A (λ1), A (λ2), and A (λ3) thus obtained, the concentration / optical path length product [oxyHb] of oxyhemoglobin in the cerebral blood flow and the concentration of deoxyhemoglobin In order to obtain the optical path length product [deoxyHb], for example, the simultaneous equations shown in the relational expressions (1), (2), and (3) are created using the Modified Beer Lambert rule, and the simultaneous equations are solved ( For example, refer nonpatent literature 1). Furthermore, the concentration / optical path length product of total hemoglobin ([oxyHb] + [deoxyHb]) is calculated from the concentration / optical path length product [oxyHb] of oxyhemoglobin and the deoxyhemoglobin concentration / optical path length product [deoxyHb]. Yes.
A (λ1) = EO (λ1) × [oxyHb] + Ed (λ1) × [deoxyHb] (1)
A (λ2) = EO (λ2) × [oxyHb] + Ed (λ2) × [deoxyHb] (2)
A (λ3) = EO (λ3) × [oxyHb] + Ed (λ3) × [deoxyHb] (3)
Note that EO (λm) is an absorbance coefficient of oxyhemoglobin in light of wavelength λm, and Ed (λm) is an absorbance coefficient of deoxyhemoglobin in light of wavelength λm.
 ここで、送光プローブと受光プローブとの間の距離(チャンネル)と、測定部位との関係について説明する。図9(a)は、一対の送光プローブ及び受光プローブと、測定部位との関係を示す断面図であり、図9(b)は、図9(a)の平面図である。
 送光プローブ12が被検者の頭部表面の送光点Tに押し当てられるとともに、受光プローブ13が被検者の頭部表面の受光点Rに押し当てられる。そして、送光プローブ12から光を照射させるとともに、受光プローブ13に頭部表面から放出される光を入射させる。このとき、光は、頭部表面の送光点Tから照射された光の内で、バナナ形状(測定領域)を通過した光が、頭部表面の受光点Rに到達する。これにより、測定領域の中でも、特に送光点Tと受光点Rとを被検者の頭部表面に沿って最短距離で結んだ線Lの中点Mから、送光点Tと受光点Rとを被検者の頭部表面に沿って最短距離で結んだ線の距離の半分の深さL/2である被検者の測定部位Sに関する受光量情報A(λ1)、A(λ2)、A(λ3)が得られるとしている。
Here, the relationship between the distance (channel) between the light transmitting probe and the light receiving probe and the measurement site will be described. FIG. 9A is a cross-sectional view showing a relationship between a pair of light transmitting probe and light receiving probe and a measurement site, and FIG. 9B is a plan view of FIG. 9A.
The light transmitting probe 12 is pressed against the light transmitting point T on the subject's head surface, and the light receiving probe 13 is pressed against the light receiving point R on the subject's head surface. Then, light is emitted from the light transmitting probe 12 and light emitted from the head surface is incident on the light receiving probe 13. At this time, the light that has passed through the banana shape (measurement region) among the light irradiated from the light transmission point T on the head surface reaches the light receiving point R on the head surface. As a result, the light transmitting point T and the light receiving point R from the middle point M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the head surface of the subject in the measurement region. Received light quantity information A (λ1), A (λ2) relating to the measurement site S of the subject having a depth L / 2 which is half the distance of the line connecting the shortest distance along the head surface of the subject. , A (λ3) is obtained.
 また、光脳機能イメージング装置では、脳の複数箇所の測定部位に関するオキシヘモグロビンの濃度・光路長積[oxyHb]、デオキシヘモグロビンの濃度・光路長積[deoxyHb]及び総ヘモグロビンの濃度・光路長積([oxyHb]+[deoxyHb])をそれぞれ測定するために、例えば、近赤外分光分析計等が利用されている。
 近赤外分光分析計においては、送光プローブと受光プローブとを所定の配列で被検者の頭部表面に接触させるために、ホルダが使用される。ホルダには貫通孔が複数個設けられ、送光プローブと受光プローブとがそれらの貫通孔に挿入されることによって、送光プローブと受光プローブとのプローブ間隔が一定となり、頭部表面から特定の深度となる受光量情報を得ている。なお、プローブ間隔は、チャンネルと呼ばれ、一般的に成人であればチャンネルを30mmとしたものが用いられ、チャンネルが30mmである場合には、チャンネルの中点からの深度15mm~20mmの受光量情報が得られると考えられている。すなわち、頭部表面から深度15mm~20mmの位置は脳表部位にほぼ対応し、脳活動に関係した受光量情報A(λ1)、A(λ2)、A(λ3)を得ている。
In the optical brain functional imaging system, oxyhemoglobin concentration / optical path length product [oxyHb], deoxyhemoglobin concentration / optical path length product [deoxyHb], and total hemoglobin concentration / optical path length product for multiple measurement sites of the brain ( In order to measure [oxyHb] + [deoxyHb]), for example, a near-infrared spectrometer is used.
In a near-infrared spectrometer, a holder is used to bring a light-transmitting probe and a light-receiving probe into contact with the subject's head surface in a predetermined arrangement. The holder is provided with a plurality of through-holes, and by inserting the light-transmitting probe and the light-receiving probe into the through-holes, the probe interval between the light-transmitting probe and the light-receiving probe is constant, and a specific distance from the head surface The received light amount information that is the depth is obtained. Note that the probe interval is called a channel, and in general, for adults, a channel with a channel of 30 mm is used. When the channel is 30 mm, the amount of light received at a depth of 15 mm to 20 mm from the midpoint of the channel Information is believed to be available. That is, the position at a depth of 15 mm to 20 mm from the head surface substantially corresponds to the brain surface region, and the received light quantity information A (λ1), A (λ2), A (λ3) related to the brain activity is obtained.
 ここで、図10は、複数の送光プローブ及び複数の受光プローブの配置を示す平面図である。15個の送光プローブ(黒丸)12と15個の受光プローブ(白丸)13とが行方向及び列方向に交互となるように正方格子状に配置されている。そして、送光プローブ12から光を出射させるとともに、光を出射した送光プローブ12に隣接した受光プローブ13に頭部表面から放出される光を検出させることにより、受光量情報A(λ1)、A(λ2)、A(λ3)を取得している。これにより、図10に示すように平面視すると、測定部位(×印)Sは、送光プローブ12と、送光プローブ12からの光を受光する受光プローブ13との中点となり、計49個の受光量情報A(λ1)、A(λ2)、A(λ3)の収集が行われる。 Here, FIG. 10 is a plan view showing the arrangement of a plurality of light transmitting probes and a plurality of light receiving probes. Fifteen light transmitting probes (black circles) 12 and fifteen light receiving probes (white circles) 13 are arranged in a square lattice pattern so as to alternate in the row direction and the column direction. Then, light is emitted from the light transmitting probe 12, and the light receiving probe 13 adjacent to the light transmitting probe 12 that has emitted the light is detected to detect the light emitted from the head surface, thereby receiving light reception amount information A (λ1), A (λ2) and A (λ3) are acquired. Accordingly, when viewed in plan as shown in FIG. 10, the measurement site (x mark) S is the midpoint between the light transmitting probe 12 and the light receiving probe 13 that receives light from the light transmitting probe 12, for a total of 49 pieces. The received light amount information A (λ1), A (λ2), and A (λ3) is collected.
 ところで、頭部表面の曲率は、男女差、年齢差、個人差によって異なるので、頭部表面の曲率の差異があっても容易に装着可能にするものとして、送光プローブ12及び受光プローブ13が保持される保持部を頭部表面に正方格子状に配置するとともに、保持部を伸縮性を示さない設定距離(例えば、30mm)の接続部で連結し、さらに、頭部表面の当接面内において保持部を回転軸として所定の角度内で接続部の回転可変性を有するホルダが提案されている(例えば、特許文献1参照)。
 ホルダ111は、送光プローブ12や受光プローブ13を固定する30個のソケット部品(保持部)133と、49個の接続部品131と、30個のナット部品132とを備える。
 図11は、送光プローブ12とナット部品132と2個の接続部品131とソケット部品133とを示す分解斜視図である。図12は、組み立てた後の送光プローブ12とナット部品132と2個の接続部品131とソケット部品133とを示す図である。
By the way, since the curvature of the head surface varies depending on gender differences, age differences, and individual differences, the light transmitting probe 12 and the light receiving probe 13 are assumed to be easily mountable even if there is a difference in curvature on the head surface. The holding parts to be held are arranged in a square lattice pattern on the head surface, and the holding parts are connected by a connection part having a set distance (for example, 30 mm) that does not exhibit stretchability, and further within the contact surface of the head surface Has proposed a holder having a rotation variability of the connecting portion within a predetermined angle with the holding portion as a rotation axis (see, for example, Patent Document 1).
The holder 111 includes 30 socket parts (holding parts) 133 for fixing the light transmitting probe 12 and the light receiving probe 13, 49 connection parts 131, and 30 nut parts 132.
FIG. 11 is an exploded perspective view showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133. FIG. 12 is a diagram showing the light transmission probe 12, the nut part 132, the two connection parts 131, and the socket part 133 after being assembled.
 接続部品131は、一の字形状の板状体である。そして、接続部品131は、両端に円環形状の挿入部131aと、両端の挿入部131aをチャンネル長さXで連結する接続部131bとを有する。各挿入部131aの中央部には、ソケット部品133が挿入されるための円形状の貫通孔がそれぞれ開けられている。また、接続部131bは、幅10mm、厚さ0.1mmであり、かつ、貫通孔の中心と貫通孔の中心との間の距離がチャンネル長さ30mmとなるように形成されており、厚さ方向にだけ可撓性を有する。つまり、両端の挿入部131aは、常にチャンネル長さ30mmで保持されるようになっている。このような接続部品131を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。 The connection component 131 is a plate-shaped body having a single letter shape. The connection component 131 includes annular insertion portions 131a at both ends, and connection portions 131b that connect the insertion portions 131a at both ends with a channel length X. A circular through-hole for inserting the socket component 133 is opened at the center of each insertion portion 131a. The connecting portion 131b has a width of 10 mm and a thickness of 0.1 mm, and is formed such that the distance between the center of the through hole and the center of the through hole is a channel length of 30 mm. Only flexible in the direction. That is, the insertion portions 131a at both ends are always held with a channel length of 30 mm. The material constituting the connection component 131 is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 ソケット部品133は、円筒形状(例えば、直径15mm)の本体部133aと、円環形状の顎部133bと、円環形状の底部(密着機構)133cとを有し、その内側に送光プローブ12や受光プローブ13を挿入可能とするとともに、本体部133aの外周面にナット部品132が螺合されるネジ(固定機構)が形成されている。
 ナット部品132は、円形状の貫通孔を有する円環形状であり、その内周面にソケット部品133の本体部133aに螺合されるメスネジが形成されている。なお、貫通孔の大きさは、上方から見ると、ソケット部品133の本体部133aの大きさよりも大きく、ソケット部品133の顎部133bよりも小さくなっている。
 これにより、ナット部品132の内側にソケット部品133の本体部133aをネジ機構を用いて挿入することで、ソケット部品133の顎部133bとナット部品132との間に接続部品131の挿入部131aを挟み込んで固定することができるようになっている。
The socket part 133 has a cylindrical body (for example, 15 mm in diameter) main body part 133a, an annular jaw part 133b, and an annular bottom part (contact mechanism) 133c. The light receiving probe 13 can be inserted, and a screw (fixing mechanism) to which the nut part 132 is screwed is formed on the outer peripheral surface of the main body 133a.
The nut part 132 has an annular shape having a circular through hole, and a female screw to be screwed to the main body part 133a of the socket part 133 is formed on the inner peripheral surface thereof. Note that the size of the through hole is larger than the size of the main body portion 133a of the socket component 133 and smaller than the jaw portion 133b of the socket component 133 when viewed from above.
Thus, the insertion portion 131a of the connection part 131 is inserted between the jaw part 133b of the socket part 133 and the nut part 132 by inserting the main body part 133a of the socket part 133 into the nut part 132 using the screw mechanism. It can be pinched and fixed.
 なお、送光プローブ12は、ソケット部品133と固定することが可能となっている円柱形状(例えば、直径5mm)をしている。そして、送光プローブ12の内部には、発光部(図示せず)と接続された光ファイバ等の導光路(例えば、直径1mm)がバネ等を介して固定されており、導光路の先端部から光が照射されるようになっている。
 また、受光プローブ13も、送光プローブ12と同様な構造となっており、ソケット部品133と固定することが可能となっている円柱形状(例えば、直径5mm)をしている。そして、受光プローブ13の内部には、光検出部(図示せず)と接続された光ファイバ等の導光路(例えば、直径1mm)がバネ等を介して固定されており、導光路の先端部から光を受光するようになっている。
The light transmitting probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the socket component 133. A light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light emitting section (not shown) is fixed inside the light transmission probe 12 via a spring or the like, and the distal end portion of the light guide path The light comes to be irradiated from.
The light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the socket component 133. A light guide path (for example, 1 mm in diameter) such as an optical fiber connected to a light detection unit (not shown) is fixed inside the light receiving probe 13 via a spring or the like, and the tip of the light guide path The light is received from.
 このような30個のソケット部品133と49個の接続部品131と30個のナット部品132とを用いて、図10に示すホルダ111を組み立てる。そして、このようなホルダ111を被検者の頭部表面に密着させるために、医者等の測定者は、ソケット部品133の顎部133bとナット部品132との間のネジ機構を少し緩めることで、図12(a)に示すように、上方から見て一の接続部品131と他の接続部品131とで、ソケット部品133を回転軸として所望角度を形成するとともに、図12(b)に示すように、接続部品131の接続部131bは可撓性を有するので、頭部表面と一致するような曲率を有する面となるように変形する。このように変形が加えられた状態で、測定者は、ソケット部品133の顎部133bとナット部品132との間のネジ機構を、しっかり固定する。すると、ホルダ111は、もはや平面には戻れず、その曲率が保持される結果となる。最後に、測定者は、ソケット部品133の内側に、送光プローブ12や受光プローブ13を所定の配列で挿入する。 The holder 111 shown in FIG. 10 is assembled using 30 socket parts 133, 49 connection parts 131, and 30 nut parts 132. And in order to make such a holder 111 closely adhere to the subject's head surface, a measurer such as a doctor slightly loosens the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. As shown in FIG. 12 (a), one connecting component 131 and the other connecting component 131 as viewed from above form a desired angle with the socket component 133 as a rotation axis, and are shown in FIG. 12 (b). Thus, since the connection part 131b of the connection component 131 has flexibility, it deform | transforms so that it may become a surface which has a curvature which corresponds with the head surface. With the deformation applied in this manner, the measurer securely fixes the screw mechanism between the jaw 133b of the socket part 133 and the nut part 132. Then, the holder 111 can no longer return to the flat surface, and the curvature is maintained. Finally, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement inside the socket component 133.
特開2009-077841号公報JP 2009-077841 A
 ところで、上述したようなホルダ111を、被検者の頭部表面に密着させるには、測定者は、一の接続部品131と他の接続部品131とで、ソケット部品133を回転軸として所望角度を形成しながら、頭部表面と一致するような曲率を有する面となるように変形するようにした上で、ソケット部品133の顎部133bとナット部品132との間のネジ機構を、しっかり固定する必要がある。しかしながら、上述したようなホルダ111を被検者の頭部表面に密着させる場合には、30箇所のソケット部品133の顎部133bとナット部品132との間のネジ機構を、しっかり固定することになり、また、ホルダを被検者の頭部表面の全面に密着させる場合には、使用する送光プローブ12や受光プローブ13の個数は多くなるので、例えば100箇所のソケット部品133とナット部品132との間のネジ機構を、しっかり固定することになり、測定者にとっては非常に手間がかるし、被検者にとっては長い時間がかかるので非常にストレスがかかった。 By the way, in order to bring the holder 111 as described above into close contact with the surface of the subject's head, the measurer uses the one connecting component 131 and the other connecting component 131 to set the socket component 133 as the rotation axis and the desired angle. The screw mechanism between the jaw part 133b of the socket part 133 and the nut part 132 is firmly fixed after being deformed so as to have a curvature that matches the head surface. There is a need to. However, when the holder 111 as described above is brought into close contact with the head surface of the subject, the screw mechanism between the jaw part 133b of the 30 socket parts 133 and the nut part 132 is firmly fixed. In addition, when the holder is brought into close contact with the entire surface of the head of the subject, the number of light transmitting probes 12 and light receiving probes 13 to be used increases, so that, for example, 100 socket parts 133 and nut parts 132 are provided. The screw mechanism between the two was fixed firmly, which was very laborious for the measurer and took a long time for the subject, and was very stressful.
 本願発明者は、上記課題を解決するために、ソケット部品133とナット部品132との間のネジ機構を調整する必要がなく、様々な曲率を有する面に対して密着することができるホルダについて検討を行った。そこで、図12(a)に示すように、上方から見て一の接続部品131と他の接続部品131とで、ソケット部品133を回転軸として所望角度を形成するものと同様な効果を奏するものとして、円環形状となるリング体(円環部)を有する挿入部材と、フック体(連結部)を有するアーム部材とを作製して、そのリング体の全部分の内から選択された任意の位置(任意角度)と、フック体とを連結すると、リング体とフック体とが連結された状態を維持したまま、リング体の所望の位置(所望角度)とフック体とが連結された状態となるように、フック体を有するアーム部材を移動可能とすることを見出した。
 また、図12(b)に示すように、接続部品131の接続部131bは可撓性を有するので、同様な効果を奏するものとして、リング体とフック体とが連結された状態を維持したまま、断面において、フック体の断面がリング体の断面に対して回動することにより、リング体を軸として、フック体を有するアーム部材を回動可能とすることを見出した。
In order to solve the above-mentioned problems, the present inventor does not need to adjust the screw mechanism between the socket part 133 and the nut part 132 and examines a holder that can be in close contact with a surface having various curvatures. Went. Therefore, as shown in FIG. 12 (a), the one connection component 131 and the other connection component 131 have the same effect as that formed by using the socket component 133 as a rotation axis when viewed from above. As described above, an insertion member having a ring body (annular portion) having an annular shape and an arm member having a hook body (connecting portion) are produced, and an arbitrary member selected from all of the ring body is selected. When the position (arbitrary angle) and the hook body are connected, the ring body and the hook body are kept connected and the desired position (desired angle) of the ring body and the hook body are connected. It has been found that the arm member having the hook body can be moved.
Also, as shown in FIG. 12 (b), since the connection portion 131b of the connection component 131 has flexibility, it is assumed that the ring body and the hook body are connected with each other as having the same effect. In the cross section, it has been found that the arm member having the hook body can be rotated about the ring body by rotating the cross section of the hook body with respect to the cross section of the ring body.
 すなわち、本発明のホルダは、先端から光を照射する複数の送光プローブと、先端から光を受光する複数の受光プローブとを保持して、被検者の頭部表面に装着されるホルダであって、送光プローブ又は受光プローブが挿入される1個の貫通孔を中央部に有する複数の挿入部材と、前記挿入部材と連結されるための連結部を両端に有し、当該連結部が第一設定距離で離れるように形成されている複数のアーム部材とを備え、前記挿入部材には、前記貫通孔の中心軸から第二設定距離で離れる円環形状となる円環部が形成されており、前記挿入部材の円環部の全部分の内から選択された任意の位置と、前記アーム部材の連結部とが連結されると、前記挿入部材の円環部とアーム部材の連結部とが連結された状態を維持したまま、前記挿入部材の円環部の所望の位置とアーム部材の連結部とが連結された状態となるように、前記頭部表面の当接面内でアーム部材が、前記貫通孔の中心軸を軸として移動可能となるとともに、前記挿入部材の円環部の所望の位置とアーム部材の連結部とが連結された状態を維持したまま、前記頭部表面の法線方向でアーム部材の連結部が円環部に対して回動することにより、前記頭部表面の法線方向でアーム部材が、前記円環部を軸として回動可能となるようにしている。 That is, the holder of the present invention is a holder that holds a plurality of light-transmitting probes that irradiate light from the tip and a plurality of light-receiving probes that receive light from the tip and is mounted on the surface of the subject's head. A plurality of insertion members having a single through-hole into which a light transmitting probe or a light receiving probe is inserted at a central portion, and connecting portions for connecting to the insertion members at both ends, the connecting portions being A plurality of arm members formed so as to be separated from each other by a first set distance, and the insertion member is formed with an annular portion having a ring shape that is separated from the central axis of the through hole by a second set distance. When the arbitrary position selected from the whole part of the annular part of the insertion member and the connecting part of the arm member are connected, the annular part of the inserting member and the connecting part of the arm member And the insertion member while maintaining the connected state. The arm member can move around the central axis of the through hole in the contact surface of the head surface so that a desired position of the annular portion and the connecting portion of the arm member are connected. In addition, while maintaining the state where the desired position of the annular part of the insertion member and the connecting part of the arm member are connected, the connecting part of the arm member becomes an annular part in the normal direction of the head surface. By rotating with respect to the head, the arm member can be rotated about the annular portion in the normal direction of the head surface.
 ここで、「第一設定距離」及び「第二設定距離」とは、設計者等によって予め決められた任意の距離であり、例えば、第一設定距離と第二設定距離の2倍との合計距離が、30mm等となる。
 本発明のホルダによれば、円環部を有する所定の個数の挿入部材と、連結部を両端に有する所定の個数のアーム部材とを備える。そして、測定者等は、まず、所定の個数の挿入部材と、所定の個数のアーム部材とを用いて、挿入部材の円環部の任意の位置とアーム部材の連結部とを連結しながら、ホルダを作製する。
Here, the “first setting distance” and the “second setting distance” are arbitrary distances determined in advance by a designer or the like, for example, the sum of the first setting distance and twice the second setting distance. The distance is 30 mm or the like.
According to the holder of the present invention, a predetermined number of insertion members having an annular portion and a predetermined number of arm members having coupling portions at both ends are provided. Then, the measurer or the like first uses a predetermined number of insertion members and a predetermined number of arm members to connect an arbitrary position of the annular portion of the insertion member and the connection portion of the arm member, Make a holder.
 次に、測定者等は、ホルダを被検者の頭部表面に密着させることになるが、挿入部材の円環部の所望の位置とアーム部材の連結部とが連結された状態となるように、頭部表面の当接面内でアーム部材が移動可能となるとともに、頭部表面の法線方向でアーム部材の連結部が円環部に対して回動することにより、頭部表面の法線方向でアーム部材が回動可能となっているので、ホルダを被検者の頭部表面に装着させていけば、ホルダは被検者の頭部表面と一致するような曲率を有する面となるように、自然に変形する。このとき、円環部は、貫通孔の中心軸から第二設定距離で離れる円環形状となっているので、挿入部材の円環部とアーム部材の連結部とが連結されていれば、一の挿入部材の貫通孔の中心軸と、他の挿入部材の貫通孔の中心軸との距離は、第一設定距離と第二設定距離の2倍との合計距離でほぼ保持されることになる。つまり、第一設定距離と第二設定距離の2倍との合計距離が、例えば、30mmであれば、脳活動に関係した受光量情報A(λ1)、A(λ2)、A(λ3)を得ることができる。 Next, the measurer or the like brings the holder into close contact with the surface of the head of the subject, but the desired position of the annular portion of the insertion member and the connecting portion of the arm member are connected. In addition, the arm member can move within the contact surface of the head surface, and the connecting portion of the arm member rotates with respect to the annular portion in the normal direction of the head surface. Since the arm member can be rotated in the normal direction, if the holder is mounted on the surface of the head of the subject, the holder has a curvature that matches the surface of the head of the subject. It will naturally deform so that At this time, since the annular portion has an annular shape that is separated from the central axis of the through hole by a second set distance, if the annular portion of the insertion member and the connecting portion of the arm member are connected, one The distance between the central axis of the through-hole of the insertion member and the central axis of the through-hole of the other insertion member is substantially held at a total distance of the first set distance and twice the second set distance. . That is, if the total distance of the first set distance and twice the second set distance is, for example, 30 mm, the received light amount information A (λ1), A (λ2), A (λ3) related to the brain activity is Obtainable.
 以上のように、本発明のホルダによれば、ソケット部品とナット部品との間のネジ機構を調整する必要がなく、様々な曲率を有する面に対して密着することができる。 As described above, according to the holder of the present invention, it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder can be in close contact with a surface having various curvatures.
(その他の課題を解決するための手段及び効果)
 また、本発明のホルダは、前記円環部は、円柱体又は多角形柱体が円環形状となったリング体であり、前記アーム部材の連結部は、前記リング体の一部分が内側に挿入されるための半円筒体又は半多角形筒体を有するフック体であるようにしてもよい。
 ここで、「半円筒体又は半多角形筒体」とは、断面において、一部が欠けた円筒体又は多角形筒体のことをいい、例えば、断面において、360°の円環形状の内の一部が欠けた270°の円環形状を有する半円筒体や、断面において、360°の正六角形筒体の内の一部が欠けた200°の正六角形筒体等が挙げられる。
 本発明のホルダによれば、円環部を、円柱体が円環形状となったリング体とし、連結部を、半円筒体を有するフック体とすることにより、フック体がリング体に対して、頭部表面の法線方向で滑らかに回動することができる。一方、円環部を、多角形柱体が円環形状となったリング体とし、連結部を、半多角形筒体を有するフック体とすることにより、フック体がリング体に対して、頭部表面の法線方向で段階的に回動することができる。
(Means and effects for solving other problems)
Further, in the holder of the present invention, the annular part is a ring body in which a cylindrical body or a polygonal column is an annular shape, and a part of the ring body is inserted inside the connection part of the arm member It may be a hook body having a semi-cylindrical body or a semi-polygonal tubular body.
Here, the “semi-cylindrical body or semi-polygonal cylindrical body” refers to a cylindrical body or a polygonal cylindrical body that is partially cut off in the cross section. And a semi-cylindrical body having a circular shape of 270 ° with a part thereof cut out, a 200 ° regular hexagonal cylinder with a part of a 360 ° regular hexagonal cylinder cut out in a cross section, and the like.
According to the holder of the present invention, the ring body is a ring body in which the columnar body has an annular shape, and the coupling part is a hook body having a semi-cylindrical body, so that the hook body is against the ring body. It can be smoothly rotated in the normal direction of the head surface. On the other hand, the ring body is a ring body in which the polygonal column has an annular shape, and the connection part is a hook body having a semi-polygonal cylindrical body, so that the hook body has a head relative to the ring body. It can be rotated stepwise in the normal direction of the part surface.
 また、本発明のホルダは、前記アーム部材の連結部は、球体、円柱体又は多角形柱体であり、前記円環部は、前記アーム部材の連結部が挿入されるための半円筒状又は半多角形筒状の溝を有するようにしてもよい。
 ここで、「半円筒状又は半多角形筒状」とは、断面において、一部が欠けた円筒状又は多角形筒状のことをいい、例えば、断面において、360°の円環形状の内の一部が欠けた270°の円環形状を有する半円筒体や、断面において、360°の正六角形の内の一部が欠けた200°の正六角形を有する正六角形筒体等が挙げられる。
 本発明のホルダによれば、連結部を球体や円柱体とし、円環部を半円筒状の溝を有するものとすることにより、連結部が円環部体に対して、頭部表面の法線方向で滑らかに回動することができる。一方、連結部を、多角形柱体とし、円環部を、半多角形筒状の溝を有するものとすることにより、連結部が円環部体に対して、頭部表面の法線方向で段階的に回動することができる。
In the holder of the present invention, the connecting portion of the arm member is a sphere, a cylindrical body, or a polygonal column, and the annular portion is a semi-cylindrical shape for inserting the connecting portion of the arm member or You may make it have a semi-polygonal cylindrical groove.
Here, the “semi-cylindrical shape or semi-polygonal cylindrical shape” means a cylindrical shape or a polygonal cylindrical shape that is partially cut off in the cross section. Examples include a semi-cylindrical body having a 270 ° annular shape with a part thereof cut off, and a regular hexagonal cylindrical body having a 200 ° regular hexagon in which a part of a 360 ° regular hexagon is missing in a cross section. .
According to the holder of the present invention, the connecting portion is a spherical body or a cylindrical body, and the annular portion has a semicylindrical groove. It can rotate smoothly in the linear direction. On the other hand, the connecting part is a polygonal column, and the annular part has a semi-polygonal cylindrical groove so that the connecting part is normal to the surface of the head relative to the annular part. Can be rotated step by step.
 また、本発明のホルダは、前記アーム部材の中央部には、送光プローブ又は受光プローブが挿入される1個の貫通孔が形成されているようにしてもよい。
 また、本発明のホルダは、前記アーム部材の中央部には、EEG電極が挿入される1個の貫通孔が形成されているようにしてもよい。
 本発明のホルダによれば、光を用いて測定した測定部位における電気信号を測定することができる。
In the holder of the present invention, a single through hole into which the light transmitting probe or the light receiving probe is inserted may be formed in the central portion of the arm member.
In the holder of the present invention, a single through hole into which the EEG electrode is inserted may be formed in the central portion of the arm member.
According to the holder of the present invention, it is possible to measure an electrical signal at a measurement site measured using light.
 そして、本発明の光生体測定装置は、上述したようなホルダと、先端から光を照射する複数の送光プローブと、先端から光を受光する複数の受光プローブと、前記送光プローブ及び受光プローブに対して光の送受光を制御する制御部とを備えるようにしている。 The optical biometric apparatus of the present invention includes a holder as described above, a plurality of light transmitting probes that irradiate light from the tip, a plurality of light receiving probes that receive light from the tip, and the light transmitting probe and the light receiving probe. And a controller for controlling light transmission / reception.
本発明の一実施形態である光生体測定装置の概略構成の一例を示すブロック図である。It is a block diagram which shows an example of schematic structure of the optical biometric apparatus which is one Embodiment of this invention. 球体に装着したホルダの一例を示す斜視図である。It is a perspective view which shows an example of the holder with which the spherical body was mounted | worn. 挿入部材と第一アーム部材と第二アーム部材との一例を示す斜視図である。It is a perspective view which shows an example of an insertion member, a 1st arm member, and a 2nd arm member. 組み立てた後の複数の挿入部材と複数の第一アーム部材と複数の第二アーム部材とを示す図である。It is a figure which shows the some insertion member, the some 1st arm member, and the some 2nd arm member after assembling. 送光プローブの一例を示す斜視図である。It is a perspective view which shows an example of a light transmission probe. 第三アーム部材の一例を示す斜視図である。It is a perspective view which shows an example of a 3rd arm member. 挿入部材と第四アーム部材と第五アーム部材との一例を示す斜視図である。It is a perspective view which shows an example of an insertion member, a 4th arm member, and a 5th arm member. 組み立てた後の複数の挿入部材と複数の第四アーム部材と複数の第五アーム部材とを示す図である。It is a figure which shows the some insertion member after assembling, a some 4th arm member, and a some 5th arm member. 一対の送光プローブ及び受光プローブと、測定部位との関係を示す図である。It is a figure which shows the relationship between a pair of light transmission probe and light reception probe, and a measurement site | part. 複数の送光プローブ及び複数の受光プローブの配置を示す平面図である。It is a top view which shows arrangement | positioning of a some light transmission probe and a some light reception probe. 送光プローブとナット部品と2個の接続部品とソケット部品とを示す分解斜視図である。It is a disassembled perspective view which shows a light transmission probe, a nut component, two connection components, and a socket component. 組み立てた後の送光プローブとナット部品と2個の接続部品とソケット部品とを示す図である。It is a figure which shows the light transmission probe, nut component, two connection components, and socket component after an assembly.
 以下、本発明の実施形態について図面を用いて説明する。なお、本発明は、以下に説明するような実施形態に限定されるものではなく、本発明の趣旨を逸脱しない範囲で種々の態様が含まれることはいうまでもない。 Hereinafter, embodiments of the present invention will be described with reference to the drawings. Note that the present invention is not limited to the embodiments described below, and it is needless to say that various aspects are included without departing from the spirit of the present invention.
<第一の実施形態>
 図1は、本発明の一実施形態である光生体測定装置の概略構成の一例を示すブロック図である。また、図2は、直径200mmの球体に装着したホルダの一例を示す斜視図である。
 光生体測定装置1は、被検者の頭部表面上に装着するためのホルダ11と、送光プローブ12と導光路(図示せず)により接続される発光部2と、受光プローブ13と導光路(図示せず)により接続される光検出部3と、EEG電極14と接続される電気検出部4と、光生体測定装置1全体の制御を実行する制御部(コンピュータ)20とにより構成される。
<First embodiment>
FIG. 1 is a block diagram showing an example of a schematic configuration of an optical biometric apparatus according to an embodiment of the present invention. FIG. 2 is a perspective view showing an example of a holder attached to a sphere having a diameter of 200 mm.
The optical biometric apparatus 1 includes a holder 11 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmission probe 12 and a light guide (not shown), a light receiving probe 13 and a light guide. The optical detection unit 3 is connected by an optical path (not shown), the electrical detection unit 4 is connected to the EEG electrode 14, and a control unit (computer) 20 that controls the entire optical biometric apparatus 1. The
 まず、ホルダ11を構成する部品について説明する。図3は、挿入部材33と第一アーム部材31と第二アーム部材32との一例を示す斜視図であり、図4は、組み立てた後の複数の挿入部材33と複数の第一アーム部材31と複数の第二アーム部材32とを示す図である。なお、図5は、送光プローブ12の一例を示す斜視図である。
 ホルダ11は、送光プローブ12や受光プローブ13を固定するための複数の挿入部材33と、一の挿入部材33と他の挿入部材33とを連結するための複数の第一アーム部材31と、一の挿入部材33と他の挿入部材33とを連結するための複数の第二アーム部材32とを備える。
First, components constituting the holder 11 will be described. 3 is a perspective view showing an example of the insertion member 33, the first arm member 31, and the second arm member 32. FIG. 4 shows a plurality of the insertion members 33 and the plurality of first arm members 31 after being assembled. And a plurality of second arm members 32. FIG. 5 is a perspective view showing an example of the light transmission probe 12.
The holder 11 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of first arm members 31 for connecting one insertion member 33 and the other insertion member 33, A plurality of second arm members 32 for connecting one insertion member 33 and another insertion member 33 are provided.
 挿入部材33は、図3(a)に示すように、円形状(例えば、直径8mm)の貫通孔33dを中央部に有する本体部33aと、円環形状の円環部33bと、本体部33aと円環部33bとを接続する4個の接続部33cとを有する。
 貫通孔33dの内側には、送光プローブ12や受光プローブ13が挿入可能となっている。これにより、貫通孔33dの内側に送光プローブ12を挿入すれば、挿入部材33と送光プローブ12とを固定することができるようになっている。
 円環部33bは、円柱体(例えば、直径1mm)が円環形状となったリング体である。そして、貫通孔33dの中心軸から第二設定距離(例えば、6.5mm)で離れるように形成されている。
 接続部33cは、本体部33aの側面と円環部33bの側面とを接続し、4個の接続部33cは、平面視すると、12時と3時と6時と9時との位置に形成されている。
 なお、上記挿入部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
As shown in FIG. 3A, the insertion member 33 includes a main body 33a having a circular (for example, a diameter of 8 mm) through hole 33d at the center, an annular ring portion 33b, and a main body 33a. And four connecting portions 33c that connect the annular portion 33b.
The light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 33d. Thereby, if the light transmission probe 12 is inserted inside the through-hole 33d, the insertion member 33 and the light transmission probe 12 can be fixed.
The annular portion 33b is a ring body in which a cylindrical body (for example, a diameter of 1 mm) has an annular shape. And it forms so that it may leave | separate with the 2nd setting distance (for example, 6.5 mm) from the central axis of 33 d of through-holes.
The connection portion 33c connects the side surface of the main body portion 33a and the side surface of the annular portion 33b, and the four connection portions 33c are formed at positions of 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock in plan view. Has been.
In addition, although it does not specifically limit as a material which comprises the said insertion member, For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
 第一アーム部材31は、図3(b)に示すように、一の字形状の板状体であり、円形状(例えば、直径8mm)の貫通孔31bを中央部に有し、連結部31aを両端に第一設定距離(例えば、18.5mm)で離れるように有する。
 貫通孔31bの内側には、送光プローブ12や受光プローブ13が挿入可能となっている。これにより、貫通孔31bの内側に送光プローブ12を挿入すれば、第一アーム部材31と送光プローブ12とを固定することができるようになっている。
 連結部31aは、断面が360°の円環形状(例えば、直径1mm)の内の一部が欠けた270°の円環形状であり、かつ、高さ3mmの半円筒体を有するフック体である。そして、下側に欠けた部分が配置されるように半円筒体は形成されている。半円筒体の内側には、欠けた部分から円環部33bの一部分が挿入可能となっている。これにより、半円筒体の内側に円環部33bを挿入すれば、第一アーム部材31と挿入部材33とを連結することができるようになっている。また、連結部31aを両端に有するので、一の連結部31aと一の挿入部材33とを連結し、もう一つの連結部31aと他の挿入部材33とを連結すれば、一の挿入部材33と他の挿入部材33とを連結することができるようになっている。このとき、一の連結部31aと他の連結部31aとが第一設定距離(例えば、18.5mm)で離れるように形成されているので、一の挿入部材33の貫通孔33dと他の挿入部材33の貫通孔33dとの間の距離は、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)となる。よって、一の挿入部材33の貫通孔33dに送光プローブ12を挿入するとともに、他の挿入部材33の貫通孔33dに受光プローブ13を挿入して、球面に配置すれば、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)が円弧状となるので、プローブ間隔(直線距離)は、例えば、30.0mmとなることになる。
As shown in FIG. 3B, the first arm member 31 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 31 b in the center portion, and a connecting portion 31 a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
The light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 31b. Thereby, if the light transmission probe 12 is inserted inside the through hole 31b, the first arm member 31 and the light transmission probe 12 can be fixed.
The connecting portion 31a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm) with a part of a circular shape of 270 ° and a semi-cylindrical body with a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the first arm member 31 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body. Moreover, since it has the connection part 31a in both ends, if one connection part 31a and the one insertion member 33 are connected and another connection part 31a and the other insertion member 33 are connected, the one insertion member 33 will be described. And the other insertion member 33 can be connected. At this time, since the one connecting portion 31a and the other connecting portion 31a are formed so as to be separated by a first set distance (for example, 18.5 mm), the through hole 33d of the one insertion member 33 and the other insertion portion The distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmitting probe 12 is inserted into the through hole 33d of one insertion member 33 and the light receiving probe 13 is inserted into the through hole 33d of the other insertion member 33 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is arcuate, the probe interval (linear distance) is, for example, 30.0 mm.
 さらに、円環部33bの全ての位置の断面が、同一な円形状となっているので、円環部33bの任意の位置(任意角度)と連結部31aとが連結されると、円環部33bと連結部31aとが連結された状態を維持したまま、円環部33bの他の位置(360°の内のどこかの角度)と連結部31aとが連結された状態となるように、第一アーム部材31が移動可能となっている。つまり、円環部33bの全部分の内から所望の位置(所望角度)と連結部31aとが連結された状態となるように、貫通孔33dの中心軸が回転軸として、第一アーム部材31が移動可能となっている。 Furthermore, since the cross-sections at all positions of the annular portion 33b have the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 31a are connected, the annular portion While maintaining the state where 33b and the connecting portion 31a are connected, the other portion (an angle within 360 °) of the annular portion 33b and the connecting portion 31a are connected. The first arm member 31 is movable. That is, the first arm member 31 uses the central axis of the through-hole 33d as a rotation axis so that a desired position (desired angle) and the coupling portion 31a are coupled to each other from all the portions of the annular portion 33b. Is movable.
 また、円環部33bの断面が、円形状となっているので、円環部33bの任意の位置と連結部31aとが連結された状態を維持したまま、断面において、連結部31aが円環部33bに対して回動することにより、円環部33bが回転軸として、第一アーム部材31が回動可能となっている。 In addition, since the cross section of the annular portion 33b is circular, the connecting portion 31a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 31a are connected. By rotating with respect to the part 33b, the 1st arm member 31 can be rotated by making the annular part 33b into a rotating shaft.
 したがって、貫通孔33dの中心軸が回転軸となるとともに、円環部33bが回転軸となるように、第一アーム部材31が2軸で回動可能となっている。
 このような第一アーム部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
Accordingly, the first arm member 31 can be rotated about two axes so that the central axis of the through-hole 33d is a rotation axis and the annular portion 33b is a rotation axis.
The material constituting the first arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 第二アーム部材32は、図3(c)に示すように、一の字形状の板状体であり、円形状(例えば、直径5mm)の1個の大貫通孔32bと円形状(例えば、直径1.2mm)の8個の小貫通孔32cとを中央部に有し、連結部32aを両端に第一設定距離(例えば、18.5mm)で離れるように有する。
 大貫通孔32bの内側には、EEG電極14が挿入可能となっている。これにより、大貫通孔32bの内側にEEG電極14を挿入すれば、第二アーム部材32とEEG電極14とを固定することができるようになっている。
 連結部32aは、断面が360°の円環形状(例えば、直径1mm)の内の一部が欠けた270°の円環形状であり、かつ、高さ3mmの半円筒体を有するフック体である。そして、下側に欠けた部分が配置されるように半円筒体は形成されている。半円筒体の内側には、欠けた部分から円環部33bの一部分が挿入可能となっている。これにより、半円筒体の内側に円環部33bを挿入すれば、第二アーム部材32と挿入部材33とを連結することができるようになっている。また、連結部32aを両端に有するので、一の連結部32aと一の挿入部材33とを連結し、もう一つの連結部32aと他の挿入部材33とを連結すれば、一の挿入部材33と他の挿入部材33とを連結することができるようになっている。このとき、一の連結部32aと他の連結部32aとが第一設定距離(例えば、18.5mm)で離れるように形成されているので、一の挿入部材33の貫通孔33dと他の挿入部材33の貫通孔33dとの間の距離は、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)となる。よって、一の挿入部材33の貫通孔33dに送光プローブ12を挿入するとともに、他の挿入部材33の貫通孔33dに受光プローブ13を挿入し、第二アーム部材32の貫通孔32bにEEG電極14を挿入すれば、EEG電極14の測定部位は、プローブ間隔の中点となることになる。
As shown in FIG. 3C, the second arm member 32 is a plate-shaped body having a single letter shape, and has one large through hole 32b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through holes 32c having a diameter of 1.2 mm) are provided at the center, and the connecting portions 32a are provided at both ends so as to be separated by a first set distance (for example, 18.5 mm).
The EEG electrode 14 can be inserted inside the large through hole 32b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 32b, the second arm member 32 and the EEG electrode 14 can be fixed.
The connecting portion 32a is a hook body having a circular shape of 270 ° in which a part of a circular shape having a cross section of 360 ° (for example, a diameter of 1 mm) is missing and a semi-cylindrical body having a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Accordingly, the second arm member 32 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semi-cylindrical body. Moreover, since it has the connection part 32a in both ends, if one connection part 32a and the one insertion member 33 are connected and another connection part 32a and the other insertion member 33 are connected, the one insertion member 33 will be obtained. And the other insertion member 33 can be connected. At this time, the one connecting portion 32a and the other connecting portion 32a are formed so as to be separated from each other by a first set distance (for example, 18.5 mm). The distance between the member 33 and the through hole 33d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, the light transmitting probe 12 is inserted into the through hole 33 d of one insertion member 33, the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 33, and the EEG electrode is inserted into the through hole 32 b of the second arm member 32. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
 さらに、円環部33bの全ての位置の断面が、同一な円形状となっているので、円環部33bの任意の位置(任意角度)と連結部32aとが連結されると、円環部33bと連結部32aとが連結された状態を維持したまま、円環部33bの他の位置(360°の内のどこかの角度)と連結部32aとが連結された状態となるように、第二アーム部材32が移動可能となっている。つまり、円環部33bの全部分の内から所望の位置(所望角度)と連結部32aとが連結された状態となるように、貫通孔33dの中心軸が回転軸として、第二アーム部材32が移動可能となっている。 Furthermore, since the cross-sections at all positions of the annular portion 33b are the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 32a are connected, the annular portion While maintaining the state where 33b and the connecting portion 32a are connected, the other position (any angle of 360 °) of the annular portion 33b and the connecting portion 32a are connected. The second arm member 32 is movable. In other words, the second arm member 32 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 32a are connected from all the portions of the annular portion 33b. Is movable.
 また、円環部33bの断面が、円形状となっているので、円環部33bの任意の位置と連結部32aとが連結された状態を維持したまま、断面において、連結部32aが円環部33bに対して回転することにより、円環部33bが回転軸として、第二アーム部材32が回動可能となっている。 Further, since the cross section of the annular portion 33b has a circular shape, the connecting portion 32a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 32a are connected. By rotating with respect to the portion 33b, the second arm member 32 is rotatable with the annular portion 33b as a rotation axis.
 したがって、貫通孔33dの中心軸が回転軸となるとともに、円環部33bが回転軸となるように、第二アーム部材32が2軸で回動可能となっている。
 このような第二アーム部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
Accordingly, the second arm member 32 can be rotated about two axes so that the central axis of the through-hole 33d serves as a rotation axis and the annular portion 33b serves as a rotation axis.
The material constituting the second arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 なお、送光プローブ12は、図5に示すように、挿入部材33と固定することが可能となっている円柱形状(例えば、直径5mm)をしている。そして、送光プローブ12の内部には、発光部2と接続された光ファイバ等の導光路(例えば、直径1mm)がバネ等を介して固定されており、導光路の先端部から光が照射されるようになっている。
 また、受光プローブ13も、送光プローブ12と同様な構造となっており、挿入部材33と固定することが可能となっている円柱形状(例えば、直径5mm)をしている。そして、受光プローブ13の内部には、光検出部3と接続された光ファイバ等の導光路(例えば、直径1mm)がバネ等を介して固定されており、導光路の先端部から光を受光するようになっている。
 さらに、EEG電極14は、第二アーム部材32の中央部(1個の大貫通孔32bと8個の小貫通孔32c)と固定することが可能となっている円柱形状(例えば、EEG電極14の外径11mm)をしている。そして、EEG電極14の下端部から電気信号を受けるようになっている。
As shown in FIG. 5, the light transmission probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the insertion member 33. A light guide path (for example, a diameter of 1 mm) such as an optical fiber connected to the light emitting section 2 is fixed inside the light transmission probe 12 via a spring or the like, and light is irradiated from the tip of the light guide path. It has come to be.
The light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the insertion member 33. A light guide path (for example, 1 mm in diameter) such as an optical fiber connected to the light detection unit 3 is fixed inside the light receiving probe 13 via a spring or the like, and light is received from the tip of the light guide path. It is supposed to be.
Furthermore, the EEG electrode 14 has a cylindrical shape (for example, the EEG electrode 14) that can be fixed to the central portion (one large through hole 32 b and eight small through holes 32 c) of the second arm member 32. The outer diameter is 11 mm). An electric signal is received from the lower end of the EEG electrode 14.
 このような複数の挿入部材33と、複数の第一アーム部材31と、複数の第二アーム部材32とを用いて、図2に示すホルダ11を組み立てる。このとき、1個の挿入部材33の円環部33bの任意の位置には、第一アーム部材31と第二アーム部材32とが交互となるように、合計4個のアーム部材31、32を連結する。そして、測定者は、このようなホルダ11を被検者の頭部表面に被せると、ホルダ11は、挿入部材33の円環部33bの所望の位置と第一アーム部材31の連結部31aとが連結された状態となり、また、挿入部材33の円環部33bの所望の位置と第二アーム部材32の連結部32aとが連結された状態となるように、頭部表面の当接面内で第一アーム部材31や第二アーム部材32が移動するとともに、頭部表面の法線方向で第一アーム部材31の連結部31aが挿入部材33の円環部33bに対して回動するように、頭部表面の法線方向で第一アーム部材31が回動し、また、頭部表面の法線方向で第二アーム部材32の連結部32aが挿入部材33の円環部33bに対して回動するように、頭部表面の法線方向で第二アーム部材32が回動する。つまり、ホルダ11は、被検者の頭部表面と一致するような曲率を有する面となるように、自然に変形する。その後、測定者は、挿入部材33の貫通孔33dに、送光プローブ12と受光プローブ13とを所定の配列で挿入するとともに、第二アーム部材32の大貫通孔32bに、EEG電極14を挿入する。 The holder 11 shown in FIG. 2 is assembled using the plurality of insertion members 33, the plurality of first arm members 31, and the plurality of second arm members 32. At this time, a total of four arm members 31, 32 are placed at arbitrary positions on the annular portion 33 b of one insertion member 33 so that the first arm member 31 and the second arm member 32 alternate. Link. Then, when the measurer puts such a holder 11 on the surface of the head of the subject, the holder 11 has a desired position of the annular portion 33b of the insertion member 33 and the connecting portion 31a of the first arm member 31. In the contact surface of the head surface so that the desired position of the annular portion 33b of the insertion member 33 and the connection portion 32a of the second arm member 32 are connected. As the first arm member 31 and the second arm member 32 move, the connecting portion 31a of the first arm member 31 rotates relative to the annular portion 33b of the insertion member 33 in the normal direction of the head surface. In addition, the first arm member 31 rotates in the normal direction of the head surface, and the connecting portion 32a of the second arm member 32 in relation to the annular portion 33b of the insertion member 33 in the normal direction of the head surface. The second arm member 3 in the direction normal to the head surface There is rotated. That is, the holder 11 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 33d of the insertion member 33, and inserts the EEG electrode 14 into the large through hole 32b of the second arm member 32. To do.
 次に、上述したホルダ11以外の構成について説明する。
 発光部2は、コンピュータ20から入力された駆動信号により複数の送光プローブ12の内から選択される1個の送光プローブ12に光を送光する光源であり、例えば、LED(発光ダイオード)やLD(レーザーダイオード)等の発光素子等である。
 上記光としては、近赤外光(例えば、780nmと805nmと830nm)が用いられる。
Next, configurations other than the above-described holder 11 will be described.
The light-emitting unit 2 is a light source that transmits light to one light-transmitting probe 12 selected from among a plurality of light-transmitting probes 12 according to a drive signal input from the computer 20, for example, an LED (light-emitting diode). And a light emitting element such as an LD (laser diode).
Near-infrared light (for example, 780 nm, 805 nm, and 830 nm) is used as the light.
 光検出部3は、複数の受光プローブ13で受光した近赤外光を個別に検出することにより、複数の受光信号をコンピュータ20に出力する検出器であり、例えば、フォトダイオードやフォトトランジスタ等の受光素子、光電子増倍管等である。
 電気検出部4は、複数のEEG電極14で受けた電気信号を個別に検出することにより、複数の電気信号をコンピュータ20に出力する検出器であり、例えば、脳波計等である。
The light detection unit 3 is a detector that outputs a plurality of light reception signals to the computer 20 by individually detecting near-infrared light received by the plurality of light reception probes 13, such as a photodiode or a phototransistor. A light receiving element, a photomultiplier tube, and the like.
The electric detector 4 is a detector that outputs a plurality of electric signals to the computer 20 by individually detecting electric signals received by the plurality of EEG electrodes 14, and is, for example, an electroencephalograph.
 コンピュータ20においては、CPU21を備え、さらに、メモリ50と、モニタ画面23a等を有する表示装置23と、入力装置であるキーボード22aやマウス22bとが連結されている。CPU21が処理する機能をブロック化して説明すると、発光部2及び光検出部3を制御する送受光部制御部40と、演算部41と、EEG電極14を制御するEEG電極制御部45と、脳活動画像表示制御部44とを有する。
 送受光部制御部40は、発光部2に駆動信号を出力する発光制御部42と、光検出部3からの受光信号を受けることにより受光信号(受光量情報)をメモリ50に記憶させる光検出制御部43とを有する。発光制御部42は、送光プローブ12に光を順次送光する駆動信号を発光部2に出力する制御を行う。光検出制御部43は、光検出部3からの受光信号を受けることにより、複数の受光プローブ13から検出された複数の測定データA(λ1)、A(λ2)、A(λ3)をメモリ50に記憶させる制御を行う。
The computer 20 includes a CPU 21, and further includes a memory 50, a display device 23 having a monitor screen 23a and the like, and a keyboard 22a and a mouse 22b as input devices. The function processed by the CPU 21 will be described as a block. The light transmitting / receiving unit control unit 40 that controls the light emitting unit 2 and the light detection unit 3, the calculation unit 41, the EEG electrode control unit 45 that controls the EEG electrode 14, and the brain And an activity image display control unit 44.
The light transmission / reception unit control unit 40 receives light reception signals from the light emission control unit 42 that outputs a drive signal to the light emission unit 2 and the light detection unit 3, and stores light reception signals (light reception amount information) in the memory 50. And a control unit 43. The light emission control unit 42 performs control to output a drive signal for sequentially transmitting light to the light transmission probe 12 to the light emitting unit 2. The light detection control unit 43 receives the light reception signals from the light detection unit 3, thereby storing a plurality of measurement data A (λ 1), A (λ 2), and A (λ 3) detected from the plurality of light reception probes 13 in the memory 50. Control to be stored in
 EEG電極制御部45は、電気検出器部4からの電気信号を受けることにより、複数のEEG電極14から検出された複数の測定データBをメモリ50に記憶させる制御を行う。
 演算部41は、メモリ50に記憶された測定データA(λ1)、A(λ2)、A(λ3)において、送光プローブ12から、送光プローブ12と隣接した受光プローブ13への測定データA(λ1)、A(λ2)、A(λ3)を取得して、取得した測定データA(λ1)、A(λ2)、A(λ3)に基づいて、各波長(オキシヘモグロビンの吸収波長及びデオキシヘモグロビンの吸収波長)の通過光強度から、オキシヘモグロビン濃度、デオキシヘモグロビン濃度及び全ヘモグロビン濃度を求める制御を行う。
 脳活動画像表示制御部44は、モニタ画面23aに、情報の表示を行う制御を行う。例えば、脳平面でのオキシヘモグロビン濃度、デオキシヘモグロビン濃度及び全ヘモグロビン濃度の等高線グラフ等を表示する。
The EEG electrode control unit 45 performs control to store the plurality of measurement data B detected from the plurality of EEG electrodes 14 in the memory 50 by receiving the electric signal from the electric detector unit 4.
The calculation unit 41 uses the measurement data A (λ1), A (λ2), and A (λ3) stored in the memory 50 to measure the measurement data A from the light transmission probe 12 to the light reception probe 13 adjacent to the light transmission probe 12. (Λ1), A (λ2), A (λ3) are obtained, and based on the obtained measurement data A (λ1), A (λ2), A (λ3), each wavelength (oxyhemoglobin absorption wavelength and deoxy) Control is performed to determine the oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration from the transmitted light intensity of the absorption wavelength of hemoglobin.
The brain activity image display control unit 44 performs control to display information on the monitor screen 23a. For example, a contour graph of oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration on the brain plane is displayed.
 以上のように、本発明の光生体測定装置1に用いるホルダ11によれば、ソケット部品とナット部品との間のネジ機構を調整する必要がなく、様々な曲率を有する面に対して密着することができる。また、近赤外光を用いて測定した測定部位における電気信号を測定することができる。 As described above, according to the holder 11 used in the photobiological measuring device 1 of the present invention, it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. be able to. Moreover, the electrical signal in the measurement site | part measured using near-infrared light can be measured.
<第二の実施形態>
 光生体測定装置は、被検者の頭部表面上に装着するためのホルダ60と、送光プローブ12と導光路により接続される発光部2と、受光プローブ13と導光路により接続される光検出部3と、光生体測定装置全体の制御を実行する制御部(コンピュータ)20とにより構成される。なお、光生体測定装置1と同様のものについては、同じ符号を付している。
 ホルダ60を構成する部品について説明する。図6(a)は、第三アーム部材34の一例を示す斜視図であり、図6(b)は、組み立てた後の複数の挿入部材33と複数の第三アーム部材34とを示す図である。
 ホルダ60は、送光プローブ12や受光プローブ13を固定する複数の挿入部材33と、一の挿入部材33と他の挿入部材33とを連結するための複数の第三アーム部材34とを備える。
<Second Embodiment>
The optical biometric apparatus includes a holder 60 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3 and the control part (computer) 20 which performs control of the whole optical biometric apparatus. In addition, the same code | symbol is attached | subjected about the thing similar to the optical biometric apparatus 1. FIG.
The parts constituting the holder 60 will be described. 6A is a perspective view showing an example of the third arm member 34, and FIG. 6B is a view showing the plurality of insertion members 33 and the plurality of third arm members 34 after being assembled. is there.
The holder 60 includes a plurality of insertion members 33 for fixing the light transmitting probe 12 and the light receiving probe 13, and a plurality of third arm members 34 for connecting one insertion member 33 and the other insertion member 33.
 第三アーム部材34は、一の字形状の板状体であり、連結部34aを両端に第一設定距離(例えば、3.5mm)で離れるように有する。
 連結部34aは、断面が360°の円環形状(例えば、直径1mm)の内の一部が欠けた270°の円環形状であり、かつ、高さ3mmの半円筒体を有するフック体である。そして、下側に欠けた部分が配置されるように半円筒体は形成されている。半円筒体の内側には、欠けた部分から円環部33bの一部分が挿入可能となっている。これにより、半円筒体の内側に円環部33bを挿入すれば、第三アーム部材34と挿入部材33とを連結することができるようになっている。また、連結部34aを両端に有するので、一の連結部34aと一の挿入部材33とを連結し、もう一つの連結部34aと他の挿入部材33とを連結すれば、一の挿入部材33と他の挿入部材33とを連結することができるようになっている。このとき、一の連結部34aと他の連結部34aとが第一設定距離(例えば、3.5mm)で離れるように形成されているので、一の挿入部材33の貫通孔33dと他の挿入部材33の貫通孔33dとの間の距離は、第一設定距離と第二設定距離の2倍との合計距離(例えば、16.5mm)となる。よって、一の挿入部材33の貫通孔33dに送光プローブ12を挿入するとともに、他の挿入部材33の貫通孔33dに受光プローブ13を挿入して、球面に配置すれば、第一設定距離と第二設定距離の2倍との合計距離(例えば、16.5mm)が円弧状となるので、プローブ間隔は、例えば、15.0mmとなることになる。
The third arm member 34 is a letter-shaped plate-like body, and has a connecting portion 34a at both ends so as to be separated by a first set distance (for example, 3.5 mm).
The connecting portion 34a is a hook body having a circular shape with a cross section of 360 ° (for example, a diameter of 1 mm), a 270 ° circular shape with a part missing, and a semi-cylindrical body with a height of 3 mm. is there. And the semi-cylindrical body is formed so that the part lacking on the lower side may be arranged. Inside the semi-cylindrical body, a part of the annular portion 33b can be inserted from the missing portion. Thus, the third arm member 34 and the insertion member 33 can be connected by inserting the annular portion 33b inside the semicylindrical body. Further, since the connecting portions 34a are provided at both ends, if one connecting portion 34a and one insertion member 33 are connected and another connecting portion 34a and another insertion member 33 are connected, one inserting member 33 is provided. And the other insertion member 33 can be connected. At this time, since the one connecting portion 34a and the other connecting portion 34a are formed so as to be separated by a first set distance (for example, 3.5 mm), the through hole 33d of the one insertion member 33 and the other insertion are inserted. The distance between the member 33 and the through hole 33d is a total distance (for example, 16.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmitting probe 12 is inserted into the through hole 33d of one insertion member 33 and the light receiving probe 13 is inserted into the through hole 33d of the other insertion member 33 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 16.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 15.0 mm.
 さらに、円環部33bの全ての位置の断面が、同一な円形状となっているので、円環部33bの任意の位置(任意角度)と連結部34aとが連結されると、円環部33bと連結部34aとが連結された状態を維持したまま、円環部33bの他の位置(360°の内のどこかの角度)と連結部34aとが連結された状態となるように、第三アーム部材34が移動可能となっている。つまり、円環部33bの全部分の内から所望の位置(所望角度)と連結部34aとが連結された状態となるように、貫通孔33dの中心軸が回転軸として、第三アーム部材34が移動可能となっている。 Furthermore, since the cross-sections of all positions of the annular portion 33b are the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 33b and the connecting portion 34a are connected, the annular portion While maintaining the state where 33b and the connecting portion 34a are connected, the other position (any angle of 360 °) of the annular portion 33b and the connecting portion 34a are connected. The third arm member 34 is movable. That is, the third arm member 34 has the central axis of the through hole 33d as a rotation axis so that a desired position (desired angle) and the connecting portion 34a are connected from all the portions of the annular portion 33b. Is movable.
 また、円環部33bの断面が、円形状となっているので、円環部33bの任意の位置と連結部34aとが連結された状態を維持したまま、断面において、連結部34aが円環部33bに対して回動することにより、円環部33bが回転軸として、第三アーム部材34が回動可能となっている。 Further, since the cross section of the annular portion 33b has a circular shape, the connecting portion 34a has an annular shape in the cross section while maintaining a state where an arbitrary position of the annular portion 33b and the connecting portion 34a are connected. By rotating with respect to the portion 33b, the third arm member 34 can be rotated with the annular portion 33b as a rotation axis.
 したがって、貫通孔33dの中心軸が回転軸となるとともに、円環部33bが回転軸となるように、第三アーム部材34が2軸で回動可能となっている。
 このような第三アーム部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
Therefore, the third arm member 34 can be rotated about two axes so that the central axis of the through-hole 33d becomes a rotation axis and the annular portion 33b becomes a rotation axis.
The material constituting the third arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 このような複数の挿入部材33と、複数の第三アーム部材34とを用いて、図6(b)に示すホルダ60を組み立てる。このとき、1個の挿入部材33の円環部33bの任意の位置には、合計4個の第三アーム部材34を連結する。そして、測定者は、このようなホルダ60を被検者の頭部表面に被せると、ホルダ60は、挿入部材33の円環部33bの所望の位置と第三アーム部材34の連結部34aとが連結された状態となるように、頭部表面の当接面内で第三アーム部材34が回動するとともに、頭部表面の法線方向で第三アーム部材34の連結部34aが挿入部材33の円環部33bに対して回動するように、頭部表面の法線方向で第三アーム部材34が回動する。つまり、ホルダ60は、被検者の頭部表面と一致するような曲率を有する面となるように、自然に変形する。その後、測定者は、挿入部材33の貫通孔33dに、送光プローブ12と受光プローブ13とを所定の配列で挿入する。 Using such a plurality of insertion members 33 and a plurality of third arm members 34, a holder 60 shown in FIG. 6B is assembled. At this time, a total of four third arm members 34 are connected to any position of the annular portion 33 b of one insertion member 33. Then, when the measurer puts such a holder 60 on the surface of the head of the subject, the holder 60 connects the desired position of the annular portion 33b of the insertion member 33 and the connecting portion 34a of the third arm member 34. The third arm member 34 rotates within the contact surface of the head surface so that the connection portion 34a of the third arm member 34 is inserted in the normal direction of the head surface. The third arm member 34 rotates in the normal direction of the head surface so as to rotate with respect to the annular portion 33b of 33. That is, the holder 60 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 into the through hole 33d of the insertion member 33 in a predetermined arrangement.
 以上のように、本発明の光生体測定装置に用いるホルダ60によれば、ソケット部品とナット部品との間のネジ機構を調整する必要がなく、様々な曲率を有する面に対して密着することができる。 As described above, according to the holder 60 used in the photobiological measurement device of the present invention, it is not necessary to adjust the screw mechanism between the socket part and the nut part, and the holder 60 is in close contact with a surface having various curvatures. Can do.
<第三の実施形態>
 光生体測定装置は、被検者の頭部表面上に装着するためのホルダ70と、送光プローブ12と導光路により接続される発光部2と、受光プローブ13と導光路により接続される光検出部3と、EEG電極14と接続される電気検出部4と、光生体測定装置全体の制御を実行する制御部(コンピュータ)20とにより構成される。なお、光生体測定装置1と同様のものについては、同じ符号を付している。
 ホルダ70を構成する部品について説明する。図7は、挿入部材73と第四アーム部材71と第五アーム部材72との一例を示す斜視図であり、図8は、組み立てた後の複数の挿入部材73と複数の第四アーム部材71と複数の第五アーム部材72とを示す図である。
 ホルダ70は、送光プローブ12や受光プローブ13を固定する複数の挿入部材73と、一の挿入部材73と他の挿入部材73とを連結するための複数の第四アーム部材71と、一の挿入部材73と他の挿入部材73とを連結するための複数の第五アーム部材72とを備える。
<Third embodiment>
The optical biometric apparatus includes a holder 70 for mounting on the head surface of a subject, a light emitting unit 2 connected by a light transmitting probe 12 and a light guide, and light connected by a light receiving probe 13 and a light guide. It is comprised by the detection part 3, the electric detection part 4 connected with the EEG electrode 14, and the control part (computer) 20 which performs control of the whole optical biometric apparatus. In addition, the same code | symbol is attached | subjected about the thing similar to the optical biometric apparatus 1. FIG.
The parts constituting the holder 70 will be described. FIG. 7 is a perspective view showing an example of the insertion member 73, the fourth arm member 71, and the fifth arm member 72. FIG. 8 shows a plurality of the insertion members 73 and the plurality of fourth arm members 71 after assembly. And a plurality of fifth arm members 72.
The holder 70 includes a plurality of insertion members 73 for fixing the light transmitting probe 12 and the light receiving probe 13, a plurality of fourth arm members 71 for connecting the one insertion member 73 and the other insertion member 73, and one A plurality of fifth arm members 72 for connecting the insertion member 73 and another insertion member 73 are provided.
 挿入部材73は、図7(a)に示すように、円形状(例えば、直径8mm)の貫通孔73dを中央部に有する本体部73aと、円環形状の円環部73bとを有する。
 貫通孔73dの内側には、送光プローブ12や受光プローブ13が挿入可能となっている。これにより、貫通孔73dの内側に送光プローブ12を挿入すれば、挿入部材73と送光プローブ12とを固定することができるようになっている。
 円環部73bは、本体部73aの側面に、360°の内の一部が欠けた270°の半円筒状(例えば、直径2mm)の溝が円環形状に形成されたものである。そして、外側に欠けた部分が配置されるように半円筒状の溝は形成されている。また、円環部73bは、貫通孔73dの中心軸から第二設定距離(例えば、6.5mm)で離れるように形成されている。
 なお、上記挿入部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
As shown in FIG. 7A, the insertion member 73 includes a main body 73a having a circular (for example, diameter of 8 mm) through-hole 73d at the center, and an annular ring portion 73b.
The light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 73d. Thereby, if the light transmission probe 12 is inserted inside the through-hole 73d, the insertion member 73 and the light transmission probe 12 can be fixed.
The annular portion 73b is formed by forming a 270 ° semi-cylindrical groove (for example, 2 mm in diameter) in a ring shape on a side surface of the main body portion 73a. A semi-cylindrical groove is formed so that a portion lacking on the outside is disposed. Further, the annular portion 73b is formed so as to be separated from the central axis of the through hole 73d by a second set distance (for example, 6.5 mm).
In addition, although it does not specifically limit as a material which comprises the said insertion member, For example, a polypropylene, a polyvinyl chloride, a polyacetal etc. are mentioned.
 第四アーム部材71は、図7(b)に示すように、一の字形状の板状体であり、円形状(例えば、直径8mm)の貫通孔71bを中央部に有し、連結部71aを両端に第一設定距離(例えば、18.5mm)で離れるように有する。
 貫通孔71bの内側には、送光プローブ12や受光プローブ13が挿入可能となっている。これにより、貫通孔71bの内側に送光プローブ12を挿入すれば、第四アーム部材71と送光プローブ12とを固定することができるようになっている。
 連結部71aは、球体(例えば、直径2mm)である。連結部71aは、円環部73bの欠けた部分から円環部73bの任意の位置に挿入可能となっている。これにより、連結部71aを円環部73bに挿入すれば、第四アーム部材71と挿入部材73とを連結することができるようになっている。また、連結部71aを両端に有するので、一の連結部71aと一の挿入部材73とを連結し、もう一つの連結部71aと他の挿入部材73とを連結すれば、一の挿入部材73と他の挿入部材73とを連結することができるようになっている。このとき、一の連結部71aと他の連結部71aとが第一設定距離(例えば、18.5mm)で離れるように形成されているので、一の挿入部材73の貫通孔73dと他の挿入部材73の貫通孔73dとの間の距離は、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)となる。よって、一の挿入部材73の貫通孔73dに送光プローブ12を挿入するとともに、他の挿入部材73の貫通孔73dに受光プローブ13を挿入して、球面に配置すれば、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)が円弧状となるので、プローブ間隔は、例えば、30.0mmとなることになる。
As shown in FIG. 7B, the fourth arm member 71 is a plate-shaped body having a single letter shape, and has a circular (for example, a diameter of 8 mm) through-hole 71b in the center portion, and a connecting portion 71a. At both ends so as to be separated by a first set distance (for example, 18.5 mm).
The light transmitting probe 12 and the light receiving probe 13 can be inserted inside the through hole 71b. Thereby, if the light transmission probe 12 is inserted inside the through hole 71b, the fourth arm member 71 and the light transmission probe 12 can be fixed.
The connecting portion 71a is a sphere (for example, a diameter of 2 mm). The connecting portion 71a can be inserted into an arbitrary position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 71a is inserted in the annular part 73b, the 4th arm member 71 and the insertion member 73 can be connected now. Moreover, since it has the connection part 71a at both ends, if one connection part 71a and the one insertion member 73 are connected and another connection part 71a and the other insertion member 73 are connected, the one insertion member 73 is connected. And the other insertion member 73 can be connected. At this time, since the one connecting portion 71a and the other connecting portion 71a are formed so as to be separated by a first set distance (for example, 18.5 mm), the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted. The distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, if the light transmission probe 12 is inserted into the through hole 73d of one insertion member 73 and the light receiving probe 13 is inserted into the through hole 73d of the other insertion member 73 and arranged on the spherical surface, the first set distance is obtained. Since the total distance (for example, 31.5 mm) with twice the second set distance is an arc, the probe interval is, for example, 30.0 mm.
 さらに、円環部73bの内部空間の断面が、同一な円形状となっているので、円環部73bの任意の位置(任意角度)と連結部71aとが連結されると、円環部73bと連結部71aとが連結された状態を維持したまま、円環部73bの他の位置(360°の内のどこかの角度)と連結部71aとが連結された状態となるように、第四アーム部材71が移動可能となっている。つまり、円環部73bの全部分の内から所望の位置(所望角度)と連結部71aとが連結された状態となるように、貫通孔73dの中心軸が回転軸として、第四アーム部材71が移動可能となっている。 Furthermore, since the cross section of the internal space of the annular portion 73b has the same circular shape, when an arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 71a are connected, the annular portion 73b. While maintaining the state where the connecting portion 71a and the connecting portion 71a are connected, the other position (any angle of 360 °) of the annular portion 73b and the connecting portion 71a are connected to each other. The four arm members 71 are movable. That is, the fourth arm member 71 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 71a are connected from all the portions of the annular portion 73b. Is movable.
 また、連結部71aの断面が、円形状となっているので、円環部73bの任意の位置と連結部71aとが連結された状態を維持したまま、断面において、連結部71aが円環部73bに対して回動することにより、円環部73bが回転軸として、第四アーム部材71が回動可能となっている。 In addition, since the cross-section of the connecting portion 71a is circular, the connecting portion 71a is in the cross-section in the cross-section while maintaining the state where the arbitrary position of the annular portion 73b and the connecting portion 71a are connected. By rotating with respect to 73b, the fourth arm member 71 can be rotated with the annular portion 73b as a rotation axis.
 したがって、貫通孔73dの中心軸が回転軸となるとともに、円環部73bが回転軸となるように、第四アーム部材71が2軸で回動可能となっている。
 このような第四アーム部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
Therefore, the fourth arm member 71 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
The material constituting the fourth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 第五アーム部材72は、図7(c)に示すように、一の字形状の板状体であり、円形状(例えば、直径5mm)の1個の大貫通孔72bと円形状(例えば、直径1.2mm)の8個の小貫通孔72cとを中央部に有し、連結部72aを両端に第一設定距離(例えば、直径18.5mm)で離れるように有する。
 大貫通孔72bの内側には、EEG電極14が挿入可能となっている。これにより、大貫通孔72bの内側にEEG電極14を挿入すれば、第五アーム部材72とEEG電極14とを固定することができるようになっている。
 連結部72aは、球体(例えば、直径2mm)である。連結部72aは、円環部73bの欠けた部分から円環部73bの任意の位置に挿入可能となっている。これにより、連結部72aを円環部73bに挿入すれば、第五アーム部材72と挿入部材73とを連結することができるようになっている。また、連結部72aを両端に有するので、一の連結部72aと一の挿入部材73とを連結し、もう一つの連結部72aと他の挿入部材73とを連結すれば、一の挿入部材73と他の挿入部材73とを連結することができるようになっている。このとき、一の連結部72aと他の連結部72aとが第一設定距離(例えば、18.5mm)で離れるように形成されているので、一の挿入部材73の貫通孔73dと他の挿入部材73の貫通孔73dとの間の距離は、第一設定距離と第二設定距離の2倍との合計距離(例えば、31.5mm)となる。よって、一の挿入部材73の貫通孔73dに送光プローブ12を挿入するとともに、他の挿入部材73の貫通孔33dに受光プローブ13を挿入し、第五アーム部材72の貫通孔72bにEEG電極14を挿入すれば、EEG電極14の測定部位は、プローブ間隔の中点となることになる。
As shown in FIG. 7C, the fifth arm member 72 is a plate-shaped body having a single letter shape, and has one large through-hole 72b having a circular shape (for example, a diameter of 5 mm) and a circular shape (for example, for example, Eight small through-holes 72c having a diameter of 1.2 mm) are provided at the center, and connecting portions 72a are provided at both ends so as to be separated by a first set distance (for example, a diameter of 18.5 mm).
The EEG electrode 14 can be inserted inside the large through hole 72b. Thereby, if the EEG electrode 14 is inserted inside the large through-hole 72b, the fifth arm member 72 and the EEG electrode 14 can be fixed.
The connecting portion 72a is a sphere (for example, a diameter of 2 mm). The connecting portion 72a can be inserted into any position of the annular portion 73b from a portion lacking the annular portion 73b. Thereby, if the connection part 72a is inserted in the annular part 73b, the 5th arm member 72 and the insertion member 73 can be connected. Moreover, since it has the connection part 72a in both ends, if one connection part 72a and the one insertion member 73 are connected and another connection part 72a and the other insertion member 73 are connected, the one insertion member 73 will be obtained. And the other insertion member 73 can be connected. At this time, since the one connecting portion 72a and the other connecting portion 72a are formed so as to be separated by a first set distance (for example, 18.5 mm), the through hole 73d of the one inserting member 73 and the other inserting portion 73 are inserted. The distance between the member 73 and the through hole 73d is a total distance (for example, 31.5 mm) of the first set distance and twice the second set distance. Therefore, the light transmitting probe 12 is inserted into the through hole 73 d of one insertion member 73, the light receiving probe 13 is inserted into the through hole 33 d of the other insertion member 73, and the EEG electrode is inserted into the through hole 72 b of the fifth arm member 72. If 14 is inserted, the measurement site of the EEG electrode 14 becomes the midpoint of the probe interval.
 さらに、円環部73bの内部空間の断面が、同一な円形状となっているので、円環部73bの任意の位置(任意角度)と連結部72aとが連結されると、円環部73bと連結部72aとが連結された状態を維持したまま、円環部73bの他の位置(360°の内のどこかの角度)と連結部72aとが連結された状態となるように、第五アーム部材72が移動可能となっている。つまり、円環部73bの全部分の内から所望の位置(所望角度)と連結部72aとが連結された状態となるように、貫通孔73dの中心軸が回転軸として、第五アーム部材72が移動可能となっている。
 また、連結部72aの断面が、円形状となっているので、円環部73bの任意の位置と連結部72aとが連結された状態を維持したまま、断面において、連結部72aが円環部73bに対して回動することにより、円環部73bが回転軸として、第五アーム部材72が回動可能となっている。
Furthermore, since the cross section of the internal space of the annular portion 73b has the same circular shape, when the arbitrary position (arbitrary angle) of the annular portion 73b and the connecting portion 72a are connected, the annular portion 73b. While maintaining the state where the connecting portion 72a is connected, the other position (any angle within 360 °) of the annular portion 73b and the connecting portion 72a are connected to each other. The five arm members 72 are movable. That is, the fifth arm member 72 has the central axis of the through hole 73d as a rotation axis so that a desired position (desired angle) and the connecting portion 72a are connected from all the portions of the annular portion 73b. Is movable.
Moreover, since the cross section of the connection part 72a is circular, the connection part 72a is in the cross section in the cross section while maintaining the state where the arbitrary position of the ring part 73b and the connection part 72a are connected. By rotating with respect to 73b, the fifth arm member 72 can be rotated with the annular portion 73b as a rotation axis.
 したがって、貫通孔73dの中心軸が回転軸となるとともに、円環部73bが回転軸となるように、第四アーム部材72が2軸で回動可能となっている。
 このような第五アーム部材を構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール等が挙げられる。
Accordingly, the fourth arm member 72 can be rotated about two axes so that the central axis of the through hole 73d serves as the rotation axis and the annular portion 73b serves as the rotation axis.
The material constituting the fifth arm member is not particularly limited, and examples thereof include polypropylene, polyvinyl chloride, and polyacetal.
 このような複数の挿入部材73と、複数の第四アーム部材71と、複数の第五アーム部材72とを用いて、図8に示すホルダ70を組み立てる。このとき、1個の挿入部材73の円環部73bの任意の位置には、第四アーム部材71と第五アーム部材72とが交互となるように、合計4個のアーム部材71、72を連結する。そして、測定者は、このようなホルダ70を被検者の頭部表面に被せると、ホルダ70は、挿入部材73の円環部73bの所望の位置と第四アーム部材71の連結部71aとが連結された状態となり、また、挿入部材73の円環部73bの所望の位置と第五アーム部材72の連結部72aとが連結された状態となるように、頭部表面の当接面内で第四アーム部材71や第五アーム部材72が移動するとともに、頭部表面の法線方向で第四アーム部材71の連結部71aが挿入部材73の円環部73bに対して回動するように、頭部表面の法線方向で第四アーム部材71が回動し、また、頭部表面の法線方向で第五アーム部材72の連結部72aが挿入部材73の円環部73bに対して回動するように、頭部表面の法線方向で第五アーム部材72が回動する。つまり、ホルダ70は、被検者の頭部表面と一致するような曲率を有する面となるように、自然に変形する。その後、測定者は、挿入部材73の貫通孔73dに、送光プローブ12と受光プローブ13とを所定の配列で挿入するとともに、第五アーム部材72の大貫通孔72bに、EEG電極14を挿入する。 The holder 70 shown in FIG. 8 is assembled using such a plurality of insertion members 73, a plurality of fourth arm members 71, and a plurality of fifth arm members 72. At this time, a total of four arm members 71, 72 are placed at arbitrary positions on the annular portion 73 b of one insertion member 73 so that the fourth arm member 71 and the fifth arm member 72 alternate. Link. Then, when the measurer puts such a holder 70 on the surface of the head of the subject, the holder 70 is connected to a desired position of the annular portion 73b of the insertion member 73 and the connecting portion 71a of the fourth arm member 71. In the contact surface of the head surface so that the desired position of the annular portion 73b of the insertion member 73 and the connection portion 72a of the fifth arm member 72 are connected. As the fourth arm member 71 and the fifth arm member 72 move, the connecting portion 71a of the fourth arm member 71 rotates relative to the annular portion 73b of the insertion member 73 in the normal direction of the head surface. In addition, the fourth arm member 71 rotates in the normal direction of the head surface, and the connecting portion 72a of the fifth arm member 72 in the normal direction of the head surface is relative to the annular portion 73b of the insertion member 73. The fifth arm member 7 in the direction normal to the head surface There is rotated. That is, the holder 70 is naturally deformed so as to be a surface having a curvature that matches the head surface of the subject. Thereafter, the measurer inserts the light transmitting probe 12 and the light receiving probe 13 in a predetermined arrangement into the through hole 73d of the insertion member 73, and inserts the EEG electrode 14 into the large through hole 72b of the fifth arm member 72. To do.
 以上のように、本発明の光生体測定装置に用いるホルダ70によれば、ソケット部品とナット部品との間のネジ機構を調整する必要がなく、様々な曲率を有する面に対して密着することができる。また、近赤外光を用いて測定した測定部位における電気信号を測定することができる。 As described above, according to the holder 70 used in the photobiological measuring device of the present invention, it is not necessary to adjust the screw mechanism between the socket part and the nut part, and it is in close contact with a surface having various curvatures. Can do. Moreover, the electrical signal in the measurement site | part measured using near-infrared light can be measured.
(他の実施形態)
(1)上述した光生体測定装置1では、円環部33bは、円柱体が円環形状となったリング体であるとともに、連結部31a、32aは、半円筒体を有するフック体であるような構成としたが、円環部は、多角形柱体が円環形状となったリング体であるとともに、連結部32aは、半多角形筒体を有するフック体であるような構成としてもよい。
(2)上述した光生体測定装置では、円環部73bは、半円筒状の溝が円環形状に形成されたものであるとともに、連結部71a、72aは、球体であるような構成としたが、円環部は、半多角形筒状の溝が円環形状に形成されたものであるとともに、連結部は、多角形柱体であるような構成としてもよい。
(Other embodiments)
(1) In the optical biometric apparatus 1 described above, the annular portion 33b is a ring body having a circular cylindrical body, and the connecting portions 31a and 32a are hook bodies having a semi-cylindrical body. However, the annular portion may be a ring body in which a polygonal column is an annular shape, and the connecting portion 32a may be a hook body having a semi-polygonal cylinder. .
(2) In the optical biometric apparatus described above, the annular portion 73b is configured such that a semi-cylindrical groove is formed in an annular shape, and the connecting portions 71a and 72a are spherical. However, the annular portion may be configured such that a semi-polygonal cylindrical groove is formed in an annular shape, and the connecting portion may be a polygonal column.
 本発明は、光を用いて非侵襲で脳活動を測定するためのホルダ及びそれを用いた光生体測定装置に利用することができる。 The present invention can be used for a holder for non-invasively measuring brain activity using light and an optical biometric apparatus using the holder.
1:光生体測定装置
11、60、70、111:ホルダ
12:送光プローブ
13:受光プローブ
20:コンピュータ(制御部)
31:第一アーム部材
31a:連結部
32:第二アーム部材
32a:連結部
33:挿入部材
33b:円環部
33d:貫通孔
41:演算部
T:送光点
R:受光点
M:中点
S:測定部位
1: Optical biometric apparatus 11, 60, 70, 111: Holder 12: Light transmitting probe 13: Light receiving probe 20: Computer (control unit)
31: 1st arm member 31a: Connection part 32: 2nd arm member 32a: Connection part 33: Insertion member 33b: Ring part 33d: Through-hole 41: Calculation part T: Light transmission point R: Light reception point M: Middle point S: Measurement site

Claims (6)

  1.  先端から光を照射する複数の送光プローブと、先端から光を受光する複数の受光プローブとを保持して、被検者の頭部表面に装着されるホルダであって、
     送光プローブ又は受光プローブが挿入される1個の貫通孔を中央部に有する複数の挿入部材と、
     前記挿入部材と連結されるための連結部を両端に有し、当該連結部が第一設定距離で離れるように形成されている複数のアーム部材とを備え、
     前記挿入部材には、前記貫通孔の中心軸から第二設定距離で離れる円環形状となる円環部が形成されており、
     前記挿入部材の円環部の全部分の内から選択された任意の位置と、前記アーム部材の連結部とが連結されると、前記挿入部材の円環部とアーム部材の連結部とが連結された状態を維持したまま、前記挿入部材の円環部の所望の位置とアーム部材の連結部とが連結された状態となるように、前記頭部表面の当接面内でアーム部材が、前記貫通孔の中心軸を軸として移動可能となるとともに、
     前記挿入部材の円環部の所望の位置とアーム部材の連結部とが連結された状態を維持したまま、前記頭部表面の法線方向でアーム部材の連結部が円環部に対して回動することにより、前記頭部表面の法線方向でアーム部材が、前記円環部を軸として回動可能となることを特徴とするホルダ。
    Holding a plurality of light-transmitting probes that irradiate light from the tip and a plurality of light-receiving probes that receive light from the tip, a holder that is attached to the surface of the subject's head,
    A plurality of insertion members each having a single through hole into which a light transmitting probe or a light receiving probe is inserted;
    A plurality of arm members each having a connecting portion to be connected to the insertion member at both ends, the connecting portion being formed at a first set distance;
    The insertion member is formed with an annular portion having an annular shape that is separated from the central axis of the through hole by a second set distance.
    When the arbitrary position selected from all the annular portions of the insertion member and the connecting portion of the arm member are connected, the annular portion of the inserting member and the connecting portion of the arm member are connected. The arm member is within the contact surface of the head surface so that the desired position of the annular portion of the insertion member and the connecting portion of the arm member are connected while maintaining the state that has been made. While being able to move around the central axis of the through hole,
    While the desired position of the annular portion of the insertion member and the connecting portion of the arm member are maintained, the connecting portion of the arm member rotates with respect to the annular portion in the normal direction of the head surface. By moving, the holder can rotate the arm member around the ring portion in the normal direction of the head surface.
  2.  前記円環部は、円柱体又は多角形柱体が円環形状となったリング体であり、
     前記アーム部材の連結部は、前記リング体の一部分が内側に挿入されるための半円筒体又は半多角形筒体を有するフック体であることを特徴とする請求項1に記載のホルダ。
    The annular portion is a ring body in which a cylindrical body or a polygonal column body has an annular shape,
    2. The holder according to claim 1, wherein the connecting portion of the arm member is a hook body having a semi-cylindrical body or a semi-polygonal tubular body into which a part of the ring body is inserted.
  3.  前記アーム部材の連結部は、球体、円柱体又は多角形柱体であり、
     前記円環部は、前記アーム部材の連結部が挿入されるための半円筒状又は半多角形筒状の溝を有することを特徴とする請求項1に記載のホルダ。
    The connecting portion of the arm member is a sphere, a cylinder, or a polygonal column,
    The holder according to claim 1, wherein the annular portion has a semi-cylindrical or semi-polygonal groove into which the connecting portion of the arm member is inserted.
  4.  前記アーム部材の中央部には、送光プローブ又は受光プローブが挿入される1個の貫通孔が形成されていることを特徴とする請求項1に記載のホルダ。 The holder according to claim 1, wherein a single through hole into which a light transmitting probe or a light receiving probe is inserted is formed in a central portion of the arm member.
  5.  前記アーム部材の中央部には、EEG電極が挿入される1個の貫通孔が形成されていることを特徴とする請求項1に記載のホルダ。 The holder according to claim 1, wherein a single through hole into which an EEG electrode is inserted is formed at a central portion of the arm member.
  6.  請求項1に記載のホルダと、
     先端から光を照射する複数の送光プローブと、
     先端から光を受光する複数の受光プローブと、
     前記送光プローブ及び受光プローブに対して光の送受光を制御する制御部とを備えることを特徴とする光生体測定装置。
    A holder according to claim 1;
    A plurality of light transmitting probes that emit light from the tip;
    A plurality of light receiving probes for receiving light from the tip;
    An optical biometric apparatus comprising: a control unit that controls light transmission / reception with respect to the light transmission probe and the light reception probe.
PCT/JP2010/050014 2010-01-05 2010-01-05 Holder and photobiological measuring device using same WO2011083563A1 (en)

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