JP5561429B2 - Holder and optical measuring device using the same - Google Patents

Holder and optical measuring device using the same Download PDF

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JP5561429B2
JP5561429B2 JP2013509676A JP2013509676A JP5561429B2 JP 5561429 B2 JP5561429 B2 JP 5561429B2 JP 2013509676 A JP2013509676 A JP 2013509676A JP 2013509676 A JP2013509676 A JP 2013509676A JP 5561429 B2 JP5561429 B2 JP 5561429B2
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light
probe
holder
probe mounting
mounting portion
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JPWO2012140713A1 (en
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晴英 宇田川
芳浩 井上
孝司 網田
理 河野
亮宏 石川
善紀 増田
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Shimadzu Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light

Description

本発明は、ホルダ及びそれを用いた光計測装置に関する。特に、生体に光を照射するための送光点、生体から出射する光を受光するための受光点をそれぞれ複数個有し、１つの送光点と１つの受光点との組ごとに定まる複数のチャンネルについての生体内部情報を測定するためのホルダ及びそれを用いた光計測装置に関する。   The present invention relates to a holder and an optical measurement device using the holder. In particular, a plurality of light transmission points for irradiating light to the living body and a plurality of light receiving points for receiving light emitted from the living body are determined for each set of one light transmission point and one light receiving point. The present invention relates to a holder for measuring in-vivo internal information about the channels of the channel and an optical measurement device using the holder.

近年、脳の活動状況を観察するために、光を用いて簡便に非侵襲で測定する光脳機能イメージング装置（光計測装置）が開発されている。このような光脳機能イメージング装置では、被検者の頭部表面上に配置した送光プローブにより、異なる３種類の波長λ１、λ２、λ３（例えば、７８０ｎｍと８０５ｎｍと８３０ｎｍ）の近赤外光を脳に照射するとともに、頭部表面上に配置した受光プローブにより、脳から放出された各波長λ１、λ２、λ３の近赤外光の強度（受光量情報）Ａ（λ１）、Ａ（λ２）、Ａ（λ３）をそれぞれ検出する。
そして、このようにして得られた受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）から、脳血流中のオキシヘモグロビンの濃度・光路長積[oxyHb]と、デオキシヘモグロビンの濃度・光路長積[deoxyHb]とを求めるために、例えば、Modified Beer Lambert則を用いて関係式（１）（２）（３）に示す連立方程式を作成して、この連立方程式を解いている（例えば、非特許文献１参照）。さらには、オキシヘモグロビンの濃度・光路長積[oxyHb]と、デオキシヘモグロビンの濃度・光路長積[deoxyHb]とから総ヘモグロビンの濃度・光路長積（[oxyHb]＋[deoxyHb]）を算出している。
Ａ（λ１）＝ＥＯ（λ１）×[oxyHb]＋Ｅｄ（λ１）×[deoxyHb]・・・（１）
Ａ（λ２）＝ＥＯ（λ２）×[oxyHb]＋Ｅｄ（λ２）×[deoxyHb]・・・（２）
Ａ（λ３）＝ＥＯ（λ３）×[oxyHb]＋Ｅｄ（λ３）×[deoxyHb]・・・（３）
なお、ＥＯ（λｍ）は、波長λｍの光におけるオキシヘモグロビンの吸光度係数であり、Ｅｄ（λｍ）は、波長λｍの光におけるデオキシヘモグロビンの吸光度係数である。In recent years, in order to observe the activity state of the brain, an optical brain functional imaging apparatus (optical measurement apparatus) that measures light simply and non-invasively has been developed. In such an optical brain functional imaging apparatus, three different types of wavelengths λ 1 , λ 2 , and λ 3 (for example, 780 nm, 805 nm, and 830 nm) are close by a light transmission probe disposed on the head surface of the subject. Infrared light is irradiated onto the brain, and the intensity (received light amount information) A of the near-infrared light of each wavelength λ 1 , λ 2 , λ 3 emitted from the brain by a light receiving probe arranged on the head surface. λ 1 ), A (λ 2 ), and A (λ 3 ) are detected.
From the received light amount information A (λ 1 ), A (λ 2 ), and A (λ 3 ) thus obtained, the concentration / optical path length product [oxyHb] of oxyhemoglobin in the cerebral blood flow, and deoxy In order to obtain the hemoglobin concentration and the optical path length product [deoxyHb], for example, the simultaneous equations shown in relational expressions (1), (2), and (3) are created using the Modified Beer Lambert rule, and the simultaneous equations are solved. (For example, refer nonpatent literature 1). Furthermore, the concentration / optical path length product of total hemoglobin ([oxyHb] + [deoxyHb]) is calculated from the concentration / optical path length product [oxyHb] of oxyhemoglobin and the deoxyhemoglobin concentration / optical path length product [deoxyHb]. Yes.
A (λ 1 ) = E O (λ 1 ) × [oxyHb] + E d (λ 1 ) × [deoxyHb] (1)
A (λ 2 ) = E O (λ 2 ) × [oxyHb] + E d (λ 2 ) × [deoxyHb] (2)
A (λ 3 ) = E O (λ 3 ) × [oxyHb] + E d (λ 3 ) × [deoxyHb] (3)
E O (λm) is an absorbance coefficient of oxyhemoglobin in light having a wavelength λm, and E d (λm) is an absorbance coefficient of deoxyhemoglobin in light having a wavelength λm.

ここで、送光プローブと受光プローブとの間の距離（チャンネル）と、測定部位との関係について説明する。図５（ａ）は、一対の送光プローブ及び受光プローブと、測定部位との関係を示す断面図であり、図５（ｂ）は、図５（ａ）の平面図である。
送光プローブ１２が被検者の頭部表面の送光点Ｔに押し当てられるとともに、受光プローブ１３が被検者の頭部表面の受光点Ｒに押し当てられる。そして、送光プローブ１２から光を照射させるとともに、受光プローブ１３に頭部表面から放出される光を入射させる。このとき、光は、頭部表面の送光点Ｔから照射された光のうちで、バナナ形状（測定領域）を通過した光が、頭部表面の受光点Ｒに到達する。これにより、測定領域の中でも、特に送光点Ｔと受光点Ｒとを被検者の頭部表面に沿って最短距離で結んだ線Ｌの中点Ｍから、送光点Ｔと受光点Ｒとを被検者の頭部表面に沿って最短距離で結んだ線の距離の半分の深さＬ／２である被検者の測定部位Ｓに関する受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）が得られるとしている。Here, the relationship between the distance (channel) between the light transmitting probe and the light receiving probe and the measurement site will be described. Fig.5 (a) is sectional drawing which shows the relationship between a pair of light transmission probe and light reception probe, and a measurement site | part, FIG.5 (b) is a top view of Fig.5 (a).
The light transmitting probe 12 is pressed against the light transmitting point T on the subject's head surface, and the light receiving probe 13 is pressed against the light receiving point R on the subject's head surface. Then, light is emitted from the light transmitting probe 12 and light emitted from the head surface is incident on the light receiving probe 13. At this time, among the light irradiated from the light transmission point T on the head surface, the light that has passed through the banana shape (measurement region) reaches the light receiving point R on the head surface. As a result, the light transmitting point T and the light receiving point R from the middle point M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the head surface of the subject in the measurement region. Received light quantity information A (λ 1 ), A (λ for the measurement site S of the subject having a depth L / 2 that is half the distance of the line connecting the head and the head along the subject's head surface. 2 ), A (λ 3 ) is obtained.

また、光脳機能イメージング装置では、脳の複数箇所の測定部位に関するオキシヘモグロビンの濃度・光路長積[oxyHb]、デオキシヘモグロビンの濃度・光路長積[deoxyHb]及び総ヘモグロビンの濃度・光路長積（[oxyHb]＋[deoxyHb]）をそれぞれ測定するために、例えば、近赤外分光分析計等が利用されている（例えば、特許文献１参照）。
図６は、従来の近赤外分光分析計の概略構成の一例を示すブロック図である。なお、見やすくするために、数本の送光用光ファイバや数本の受光用光ファイバ等を省略している。
近赤外分光分析計２０１は、直方体形状の筐体１１を有する。
筐体１１の内部には、光を出射する光源２と、光源２を駆動する光源駆動機構４と、光を検出する光検出器３と、Ａ／Ｄ（Ａ／Ｄコンバータ）５と、送受光用制御部２１と、解析用制御部２２と、メモリ２３とを備えるとともに、筐体１１の外部には、６４個の送光プローブ１２と、６４個の受光プローブ１３と、６４本の送光用光ファイバ１４と、６４本の受光用光ファイバ１５と、モニタ画面２６ａ等を有する表示装置２６と、キーボード（入力装置）２７とを備える。In the optical brain functional imaging system, oxyhemoglobin concentration / optical path length product [oxyHb], deoxyhemoglobin concentration / optical path length product [deoxyHb] and total hemoglobin concentration / optical path length product (multiple measurement sites in the brain) In order to measure [oxyHb] + [deoxyHb]), for example, a near-infrared spectrometer is used (see, for example, Patent Document 1).
FIG. 6 is a block diagram showing an example of a schematic configuration of a conventional near-infrared spectrometer. For ease of viewing, several light transmitting optical fibers and several light receiving optical fibers are omitted.
The near-infrared spectrometer 201 has a rectangular parallelepiped casing 11.
Inside the housing 11, a light source 2 that emits light, a light source driving mechanism 4 that drives the light source 2, a light detector 3 that detects light, an A / D (A / D converter) 5, and a transmitter The light receiving control unit 21, the analysis control unit 22, and the memory 23 are provided, and 64 light transmission probes 12, 64 light reception probes 13, and 64 light transmission probes are provided outside the housing 11. The optical fiber 14 for light, the 64 optical fibers 15 for light reception, the display apparatus 26 which has the monitor screen 26a, etc., and the keyboard (input device) 27 are provided.

光源駆動機構４は、送受光用制御部２１から入力された駆動信号により光源２を駆動する。光源２は、例えば、異なる３種類の波長λ１、λ２、λ３の近赤外光を出射することができる半導体レーザＬＤ１、ＬＤ２、ＬＤ３等である。
光検出器３は、近赤外光をそれぞれ検出することにより、受光信号（受光量情報）Ａ（λ１）、Ａ（λ２）、Ａ（λ３）をＡ／Ｄ５を介して送受光用制御部２１に出力する検出器であり、例えば、光電子増倍管等である。The light source drive mechanism 4 drives the light source 2 by a drive signal input from the light transmission / reception controller 21. The light source 2 is, for example, a semiconductor laser LD1, LD2, or LD3 that can emit near-infrared light having three different wavelengths λ 1 , λ 2 , and λ 3 .
The photodetector 3 transmits and receives light reception signals (light reception amount information) A (λ 1 ), A (λ 2 ), and A (λ 3 ) via A / D 5 by detecting near infrared light respectively. For example, a photomultiplier tube.

送光用光ファイバ１４と受光用光ファイバ１５とは、直径２ｍｍ、長さ２ｍ〜１０ｍの管状であり、近赤外光を軸方向に伝達することができ、一端部から入射した近赤外光が、内部を通過して他端部から出射したり、他端部から入射した近赤外光が、内部を通過して一端部から出射したりするようになっている。
１本の送光用光ファイバ１４は、１個の送光用プローブ１２と、光源２の１個の半導体レーザＬＤ１、ＬＤ２、ＬＤ３とを設定長さ（２ｍ〜１０ｍ）で離れるように両端部に接続している。
１本の受光用光ファイバ１５は、１個の受光用プローブ１３と、光検出器３の１個の光電子増倍管とを設定長さ（２ｍ〜１０ｍ）で離れるように両端部に接続している。The optical fiber for light transmission 14 and the optical fiber for light reception 15 are tubular having a diameter of 2 mm and a length of 2 m to 10 m, can transmit near infrared light in the axial direction, and is incident from one end. Light passes through the inside and exits from the other end, or near-infrared light incident from the other end passes through the inside and exits from one end.
One light transmission optical fiber 14 has both end portions so that one light transmission probe 12 and one semiconductor laser LD1, LD2, LD3 of the light source 2 are separated by a set length (2 m to 10 m). Connected to.
One light receiving optical fiber 15 connects one light receiving probe 13 and one photomultiplier tube of the photodetector 3 to both ends so as to be separated by a set length (2 m to 10 m). ing.

このような近赤外分光分析計２０１においては、６４個の送光プローブ１２と６４個の受光プローブ１３とを所定の配列で被検者の頭部表面に接触させるために、ホルダ３０が使用される。図７は、６４個の送光プローブと６４個の受光プローブとが挿入されるホルダ３０の一例を示す平面図である。
送光プローブ１２Ｔ１〜１２Ｔ６４と受光プローブ１３Ｒ１〜１３Ｒ６４とは、縦方向に１６個と横方向に１６個とに交互となるように配置されることになる。これにより、送光プローブ１２と受光プローブ１３とのプローブ間隔が一定となり、頭部表面から特定の深度となる受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）を得ている。なお、一般的にチャンネルを３０ｍｍとしたものが用いられ、チャンネルが３０ｍｍである場合には、チャンネルの中点からの深度１５ｍｍ〜２０ｍｍの受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）が得られると考えられている。すなわち、頭部表面から深度１５ｍｍ〜２０ｍｍの位置は脳表部位にほぼ対応し、脳活動に関係した受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）を得ている。In such a near-infrared spectrometer 201, the holder 30 is used to bring the 64 light transmitting probes 12 and the 64 light receiving probes 13 into contact with the subject's head surface in a predetermined arrangement. Is done. FIG. 7 is a plan view showing an example of the holder 30 into which 64 light transmitting probes and 64 light receiving probes are inserted.
The light transmitting probes 12 T1 to 12 T64 and the light receiving probes 13 R1 to 13 R64 are alternately arranged in 16 pieces in the vertical direction and 16 pieces in the horizontal direction. As a result, the light receiving amount information A (λ 1 ), A (λ 2 ), and A (λ 3 ) that makes the probe interval between the light transmitting probe 12 and the light receiving probe 13 constant and a specific depth from the head surface is obtained. ing. In general, a channel with a channel of 30 mm is used. When the channel is 30 mm, the received light amount information A (λ 1 ), A (λ 2 ) at a depth of 15 mm to 20 mm from the midpoint of the channel, It is believed that A (λ 3 ) is obtained. That is, the position of 15 mm to 20 mm in depth from the head surface substantially corresponds to the brain surface region, and the received light quantity information A (λ 1 ), A (λ 2 ), A (λ 3 ) related to the brain activity is obtained. .

ところで、このような６４個の送光プローブ１２Ｔ１〜１２Ｔ６４と６４個の受光プローブ１３Ｒ１〜１３Ｒ６４との位置関係では、１個の受光プローブ１３で、複数個の送光プローブ１２から照射された光を同時に受光せず、１個の送光プローブ１２から照射された光のみを受光するように、送光プローブ１２から光を照射するタイミングと、受光プローブ１３で光を受光するタイミングとを調整する必要がある。このため、メモリ２３には、光源２で光を出射するタイミングと光検出器３で光を検出するタイミングとを示す制御テーブルが記憶されている。
このような制御テーブルがメモリ２３に記憶された送受光用制御部２１は、所定の時間に、１個の送光プローブ１２に光を送光する駆動信号を光源駆動機構４に出力するとともに、受光プローブ１３で受光された受光信号（受光量情報）を光検出器３で検出する。
その結果、図７に示すように平面視すると、合計２３２個（Ｓ１〜Ｓ２３２）の受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）の収集が行なわれる。
そして、解析用制御部２２は、合計２３２個の受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）に基づいて、関係式（１）（２）（３）を用いて、各波長（オキシヘモグロビンの吸収波長及びデオキシヘモグロビンの吸収波長）の通過光強度から、オキシヘモグロビンの濃度・光路長積[oxyHb]、デオキシヘモグロビンの濃度・光路長積[deoxyHb]及び総ヘモグロビンの濃度・光路長積（[oxyHb]＋[deoxyHb]）を求めている。By the way, in such a positional relationship between the 64 light transmitting probes 12 T1 to 12 T64 and the 64 light receiving probes 13 R1 to 13 R64 , a single light receiving probe 13 irradiates from a plurality of light transmitting probes 12. The timing of irradiating light from the light transmitting probe 12 and the timing of receiving light by the light receiving probe 13 so that only the light irradiated from one light transmitting probe 12 is received without simultaneously receiving the received light. Need to be adjusted. For this reason, the memory 23 stores a control table indicating the timing of emitting light by the light source 2 and the timing of detecting light by the photodetector 3.
The light transmission / reception control unit 21 having such a control table stored in the memory 23 outputs a drive signal for transmitting light to one light transmission probe 12 to the light source drive mechanism 4 at a predetermined time. A light reception signal (light reception amount information) received by the light reception probe 13 is detected by the photodetector 3.
As a result, a total of 232 (S1 to S232) received light amount information A (λ 1 ), A (λ 2 ), and A (λ 3 ) are collected when viewed in plan as shown in FIG.
Then, the analysis control unit 22 uses relational expressions (1), (2), and (3) based on a total of 232 received light amount information A (λ 1 ), A (λ 2 ), and A (λ 3 ). From the intensity of transmitted light at each wavelength (oxyhemoglobin absorption wavelength and deoxyhemoglobin absorption wavelength), oxyhemoglobin concentration / optical path length product [oxyHb], deoxyhemoglobin concentration / optical path length product [deoxyHb], and total hemoglobin The product of concentration and optical path length ([oxyHb] + [deoxyHb]) is obtained.

しかしながら、上述したようなホルダ３０を被検者の頭部表面に装着するには、医師等にとっては非常に手間がかかり、被検者にとっては長い時間拘束されるため非常にストレスがかかるものであった。
そこで、本出願人は、被検者がホルダを頭部に装着する際に、被検者一人でも短時間で装着することができるように、ホルダ自体が毛髪を掻き分けるようにした櫛型形状のホルダを以前に着想し出願した（例えば、特許文献２や特許文献３参照）。図１０は、櫛型形状のホルダの一例を示す平面図である。ホルダ６０は、１本の直線状の基幹部６２と、５本の直線状の枝部６１とを備える。このようなホルダ６０によれば、被検者一人でも自分自身の頭部にホルダ６０を装着することができる。However, mounting the holder 30 as described above on the surface of the subject's head is very time-consuming for doctors and the like, and is very stressful because the subject is restrained for a long time. there were.
Therefore, the present applicant has a comb-shaped configuration in which the holder itself scrapes the hair so that even when the subject wears the holder on the head, even the subject can wear it in a short time. Was previously conceived and applied for (see, for example, Patent Document 2 and Patent Document 3). FIG. 10 is a plan view showing an example of a comb-shaped holder. The holder 60 includes one straight basic portion 62 and five straight branch portions 61. According to such a holder 60, even one subject can mount the holder 60 on his / her own head.

特開２００１−３３７０３３号公報JP 2001-337033 A 国際特許出願番号ＰＣＴ／ＪＰ２０１０／０５４６２８International Patent Application Number PCT / JP2010 / 054628 国際特許出願番号ＰＣＴ／ＪＰ２０１０／０６２０８６International patent application number PCT / JP2010 / 062086

Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters, NeuroImage 18, 865-879, 2003Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters, NeuroImage 18, 865-879, 2003

しかしながら、上述したようなホルダ６０では、円柱形状（例えば、直径５ｍｍ）の送光プローブや円柱形状（例えば、直径５ｍｍ）の受光プローブを挿入するためのプローブ装着部６１ａが、枝部６１の先端から離れて形成されていたため、枝部６１の先端で毛髪を掻き分けても、掻き分けた毛髪がプローブ装着部６１ａ周辺に入り込んでくることがあった。   However, in the holder 60 as described above, a probe mounting portion 61a for inserting a cylindrical light transmission probe (for example, a diameter of 5 mm) or a cylindrical light reception probe (for example, a diameter of 5 mm) is provided at the tip of the branch portion 61. Therefore, even if the hair is scraped off at the tip of the branch portion 61, the scraped hair may enter the periphery of the probe mounting portion 61a.

本件発明者らは、上記課題を解決するために、毛髪がプローブ装着部周辺に入り込むことを防止する方法について検討を行った。そこで、枝部の先端にプローブ装着部を形成することを見出した。   In order to solve the above problems, the present inventors have studied a method for preventing hair from entering the vicinity of the probe mounting portion. Therefore, it has been found that a probe mounting portion is formed at the tip of the branch portion.

すなわち、本発明のホルダは、少なくとも２個のプローブ装着部を有し、当該プローブ装着部に先端から光を照射する送光プローブ、又は、先端から光を受光する受光プローブが挿入されて、被検者の頭部に装着されるホルダであって、第一方向に伸びた直線状の基幹部と、前記第一方向と異なる第二方向に伸びた少なくとも２本の直線状の枝部とを備え、前記第二方向から毛髪を掻き分けながら挿入していくことが可能な櫛型形状となっており、前記プローブ装着部は、前記枝部の先端に形成されているようにしている。 That is, the holder of the present invention has at least two probe mounting portions, and a light transmitting probe that irradiates light from the tip or a light receiving probe that receives light from the tip is inserted into the probe mounting portion, A holder to be attached to the examiner's head, comprising: a linear trunk extending in the first direction; and at least two linear branches extending in a second direction different from the first direction. A comb-like shape that can be inserted while scraping hair from the second direction, and the probe mounting part is formed at the tip of the branch part.

ここで、「第一方向」や「第二方向」とは、ホルダの設計者等によって予め決められた任意の方向であり、第一方向や第二方向とは上方と垂直となることが好ましく、さらに第一方向と第二方向とはお互いに垂直となることが好ましく、例えば、第二方向は毛髪を掻き分けながらホルダを挿入しやすくなる前後方向等となる。   Here, the “first direction” and the “second direction” are arbitrary directions determined in advance by a designer of the holder, and the first direction and the second direction are preferably perpendicular to the upper side. Furthermore, the first direction and the second direction are preferably perpendicular to each other. For example, the second direction is a front-rear direction or the like that facilitates insertion of the holder while scraping the hair.

本発明のホルダは、第一方向に伸びた直線状の基幹部と、第二方向に伸びた少なくとも２個の直線状の枝部とを備える。つまり、ホルダは櫛型形状となっている。そして、プローブ装着部は枝部の先端に形成されている。これにより、被検者は、頭部にホルダを装着する際に、第二方向から枝部の先端（プローブ装着部）で毛髪を掻き分けながらホルダを挿入していくことになる。   The holder of the present invention includes a linear trunk extending in the first direction and at least two linear branches extending in the second direction. That is, the holder has a comb shape. And the probe mounting part is formed in the front-end | tip of a branch part. Thus, when the subject mounts the holder on the head, the subject inserts the holder while scraping the hair from the tip of the branch (probe mounting portion) from the second direction.

以上のように、本発明のホルダによれば、被検者一人でも自分自身の頭部に短時間で容易にホルダを装着することができる。   As described above, according to the holder of the present invention, even one subject can easily attach the holder to his / her head in a short time.

（その他の課題を解決するための手段及び効果）
また、本発明のホルダは、前記プローブ装着部は、前記送光プローブ又は受光プローブが挿入される貫通孔を有し、前記プローブ装着部の下端部が、前記枝部の下面から突出しているようにしている。
また、本発明のホルダは、前記プローブ装着部の下端部が、下方から視ると、円環形状となっているようにしている。(Means and effects for solving other problems)
In the holder of the present invention, the probe mounting part has a through hole into which the light transmitting probe or the light receiving probe is inserted, and a lower end part of the probe mounting part protrudes from a lower surface of the branch part. I have to.
In the holder of the present invention, the lower end portion of the probe mounting portion has an annular shape when viewed from below.

また、本発明のホルダは、前記プローブ装着部に対応する位置に穴が形成された遮光布を備え、前記穴に前記プローブ装着部を貫通させるようにして前記遮光布が取り付けられるようにしている。
本発明のホルダによれば、櫛型形状のホルダであっても、外部光を遮光することができる。Further, the holder of the present invention includes a light shielding cloth having a hole formed at a position corresponding to the probe mounting portion, and the light shielding cloth is attached so as to penetrate the probe mounting portion into the hole. .
According to the holder of the present invention, external light can be shielded even with a comb-shaped holder.

また、本発明のホルダは、両端に挿入部と、両端の挿入部を設定距離で連結する連結部とを有する固定部材を備え、各挿入部には、前記プローブ装着部が挿入されるための貫通孔がそれぞれ開けられており、前記貫通孔に前記プローブ装着部を貫通させるようにして前記固定部材が取り付けられるようにしている。
ここで、「設定距離」とは、得ようとする受光量情報の位置の深さに応じて予め決められた任意の距離であって、例えば、脳活動に関係した受光量情報を得ようとした場合には、３０ｍｍ等となる。In addition, the holder of the present invention includes a fixing member having an insertion portion at both ends and a connecting portion for connecting the insertion portions at both ends at a set distance, and the probe mounting portion is inserted into each insertion portion. Through holes are respectively opened, and the fixing member is attached so as to penetrate the probe mounting portion through the through holes.
Here, the “set distance” is an arbitrary distance determined in advance according to the depth of the position of the received light amount information to be obtained. For example, the received light amount information related to the brain activity is obtained. In such a case, it becomes 30 mm or the like.

そして、本発明の光計測装置は、上述したようなホルダと、前記被検者に光を照射する送光プローブと、前記被検者から放出される光を受光する受光プローブと、前記送光プローブ及び受光プローブを制御することで、前記被検者の脳活動に関する測定データを得る制御部とを備えるようにしている。   The optical measurement device of the present invention includes a holder as described above, a light transmission probe that irradiates light to the subject, a light reception probe that receives light emitted from the subject, and the light transmission. A control unit that obtains measurement data related to the brain activity of the subject by controlling the probe and the light receiving probe is provided.

本発明の一実施形態である光計測装置の概略構成を示すブロック図。The block diagram which shows schematic structure of the optical measuring device which is one Embodiment of this invention. ホルダの一例を示す図。The figure which shows an example of a holder. ホルダの一例を示す図。The figure which shows an example of a holder. ホルダの一例を示す図。The figure which shows an example of a holder. 一対の送光プローブ及び受光プローブと、測定部位との関係を示す図。The figure which shows the relationship between a pair of light transmission probe and light reception probe, and a measurement region. 従来の近赤外分光分析計の概略構成の一例を示すブロック図。The block diagram which shows an example of schematic structure of the conventional near-infrared spectrometer. ホルダの一例を示す平面図。The top view which shows an example of a holder. 遮光布が取り付けられたホルダの図。The figure of the holder to which the light shielding cloth was attached. 固定部材が取り付けられたホルダの図。The figure of the holder to which the fixing member was attached. ホルダの一例を示す図。The figure which shows an example of a holder.

以下、本発明の実施形態について図面を用いて説明する。なお、本発明は、以下に説明するような実施形態に限定されるものではなく、本発明の趣旨を逸脱しない範囲で種々の態様が含まれることはいうまでもない。   Hereinafter, embodiments of the present invention will be described with reference to the drawings. Note that the present invention is not limited to the embodiments described below, and it goes without saying that various aspects are included without departing from the spirit of the present invention.

図１は、本発明の一実施形態である光計測装置の概略構成を示すブロック図である。また、図２〜図４は、ホルダの一例を示す図である。なお、近赤外分光分析計２０１と同様のものについては、同じ符号を付している。
光計測装置１は、直方体形状の筐体１１を有する。
筐体１１の内部には、光を出射する光源２と、光源２を駆動する光源駆動機構４と、光を検出する光検出器３と、Ａ／Ｄ５と、送受光用制御部２１と、解析用制御部２２と、メモリ２３とを備えるとともに、筐体１１の外部には、６４個の送光プローブ１２と、６４個の受光プローブ１３と、６４本の送光用光ファイバ１４と、６４本の受光用光ファイバ１５と、モニタ画面２６ａ等を有する表示装置２６と、キーボード（入力装置）２７とを備える。FIG. 1 is a block diagram showing a schematic configuration of an optical measurement apparatus according to an embodiment of the present invention. Moreover, FIGS. 2-4 is a figure which shows an example of a holder. The same reference numerals are assigned to the same components as those of the near-infrared spectrometer 201.
The optical measuring device 1 has a rectangular parallelepiped housing 11.
Inside the housing 11, a light source 2 that emits light, a light source driving mechanism 4 that drives the light source 2, a light detector 3 that detects light, an A / D 5, a light transmission / reception control unit 21, An analysis control unit 22 and a memory 23 are provided, and 64 light-transmitting probes 12, 64 light-receiving probes 13, and 64 light-transmitting optical fibers 14 are provided outside the housing 11. It includes 64 light receiving optical fibers 15, a display device 26 having a monitor screen 26 a and the like, and a keyboard (input device) 27.

ここで、ホルダ１６０について説明する。図２は、ホルダの平面図であり、図３は、図２に示すホルダの斜視図である。
ホルダ１６０は、直線状の基幹部１６２と、８本の直線状の枝部１６１とを備える。
基幹部１６２は、前方から見るとＸ方向（第一方向）に伸びており、上方から見ると円弧状となっている。そして、例えば、幅１５ｍｍ、厚さ２ｍｍとなっている。Here, the holder 160 will be described. FIG. 2 is a plan view of the holder, and FIG. 3 is a perspective view of the holder shown in FIG.
The holder 160 includes a linear trunk portion 162 and eight linear branch portions 161.
The backbone 162 extends in the X direction (first direction) when viewed from the front, and has an arc shape when viewed from above. For example, the width is 15 mm and the thickness is 2 mm.

第一左側枝部１６１ａは、基幹部１６２の左端部からＸ方向と４５°の角度となるＹ方向（第二方向）に伸びており、例えば、幅１５ｍｍ、厚さ２ｍｍ、長さ５０ｍｍとなっている。さらに、第一左側枝部１６１ａの先端に、平面視で円形状（例えば、直径５ｍｍ）の貫通孔を有する円筒形状のプローブ装着部１７１ａが形成されている。なお、プローブ装着部１７１ａの下端部は、第一左側枝部１６１ａの下面から突出している。
第二左側枝部１６１ｂは、基幹部１６２の左端部から５０ｍｍ中央に寄った位置からＸ方向と６０°の角度となるＹ方向（第二方向）に伸びており、例えば、幅１５ｍｍ、厚さ２ｍｍ、長さ７０ｍｍとなっている。さらに、第二左側枝部１６１ｂの先端に、平面視で円形状（例えば、直径５ｍｍ）の貫通孔を有する円筒形状のプローブ装着部１７１ｂが形成されている。なお、プローブ装着部１７１ｂの下端部は、第二左側枝部１６１ｂの下面から突出している。The first left side branch portion 161a extends from the left end portion of the trunk portion 162 in the Y direction (second direction) at an angle of 45 ° with the X direction, and has a width of 15 mm, a thickness of 2 mm, and a length of 50 mm, for example. ing. Furthermore, a cylindrical probe mounting portion 171a having a circular (for example, diameter of 5 mm) through-hole in a plan view is formed at the tip of the first left side branch portion 161a. In addition, the lower end part of the probe mounting part 171a protrudes from the lower surface of the 1st left side branch part 161a.
The second left branch 161b extends in a Y direction (second direction) at an angle of 60 ° with respect to the X direction from a position closer to the center of 50 mm from the left end of the trunk portion 162, and has a width of 15 mm and a thickness, for example. It is 2 mm and length is 70 mm. Further, a cylindrical probe mounting portion 171b having a circular (for example, diameter of 5 mm) through-hole in a plan view is formed at the tip of the second left side branch portion 161b. The lower end portion of the probe mounting portion 171b protrudes from the lower surface of the second left side branch portion 161b.

第三左側枝部１６１ｃは、基幹部１６２の左端部から７０ｍｍ中央に寄った位置からＸ方向と７５°の角度となるＹ方向（第二方向）に伸びており、例えば、幅１５ｍｍ、厚さ２ｍｍ、長さ８５ｍｍとなっている。さらに、第三左側枝部１６１ｃの先端に、平面視で円形状（例えば、直径５ｍｍ）の貫通孔を有する円筒形状のプローブ装着部１７１ｃが形成されている。なお、プローブ装着部１７１ｃの下端部は、第三左側枝部１６１ｃの下面から突出している。
中央枝部１６１ｉは、基幹部１６２の中央部からＸ方向と９０°の角度となるＹ方向（第二方向）に伸びており、例えば、幅１５ｍｍ、厚さ２ｍｍ、長さ６０ｍｍとなっている。
第四左側枝部１６１ｄは、中央枝部１６１ｉの上端部からＸ方向と４５°の角度となるＹ方向（第二方向）に伸びており、例えば、幅１５ｍｍ、厚さ２ｍｍ、長さ７０ｍｍとなっている。さらに、第四左側枝部１６１ｄの先端に、平面視で円形状（例えば、直径５ｍｍ）の貫通孔を有する円筒形状のプローブ装着部１７１ｄが形成されている。なお、プローブ装着部１７１ｄの下端部は、第四左側枝部１６１ｄの下面から突出している。The third left branch 161c extends in the Y direction (second direction) at an angle of 75 ° with respect to the X direction from a position closer to the center of 70 mm from the left end of the trunk 162, and has a width of 15 mm and a thickness, for example. It is 2 mm and length is 85 mm. Further, a cylindrical probe mounting portion 171c having a circular (for example, diameter of 5 mm) through hole in a plan view is formed at the tip of the third left side branch portion 161c. In addition, the lower end part of the probe mounting part 171c protrudes from the lower surface of the third left side branch part 161c.
The central branch portion 161i extends from the central portion of the trunk portion 162 in the Y direction (second direction) at an angle of 90 ° with the X direction, and has a width of 15 mm, a thickness of 2 mm, and a length of 60 mm, for example. .
The fourth left branch 161d extends from the upper end of the central branch 161i in the Y direction (second direction) at an angle of 45 ° with the X direction. For example, the width is 15 mm, the thickness is 2 mm, and the length is 70 mm. It has become. Further, a cylindrical probe mounting portion 171d having a circular (for example, diameter of 5 mm) through hole in a plan view is formed at the tip of the fourth left side branch portion 161d. The lower end portion of the probe mounting portion 171d protrudes from the lower surface of the fourth left side branch portion 161d.

このような構成により、第一左側枝部１６１ａのプローブ装着部１７１ａと、第二左側枝部１６１ｂのプローブ装着部１７１ｂと、第三左側枝部１６１ｃのプローブ装着部１７１ｃと、第四左側枝部１６１ｄのプローブ装着部１７１ｄとで、一辺が３１．５ｍｍとなる第一の平行四辺形が形成される。
また、ホルダ１６０の右半分についても、上述したホルダ１６０の左半分と同様の構造となっており、第一右側枝部１６１ｅのプローブ装着部１７１ｅと、第二右側枝部１６１ｆのプローブ装着部１７１ｆと、第三右側枝部１６１ｇのプローブ装着部１７１ｇと、第四右側枝部１６１ｈのプローブ装着部１７１ｈとで、一辺が３１．５ｍｍとなる第二の平行四辺形が形成される。With such a configuration, the probe mounting portion 171a of the first left branch portion 161a, the probe mounting portion 171b of the second left branch portion 161b, the probe mounting portion 171c of the third left branch portion 161c, and the fourth left branch portion A first parallelogram having a side of 31.5 mm is formed with the probe mounting portion 171d of 161d.
Also, the right half of the holder 160 has the same structure as the left half of the holder 160 described above, and the probe mounting portion 171e of the first right branch 161e and the probe mounting portion 171f of the second right branch 161f. A second parallelogram having one side of 31.5 mm is formed by the probe mounting portion 171g of the third right branch 161g and the probe mounting portion 171h of the fourth right branch 161h.

送光プローブ１２は、プローブ装着部１７１ａ〜１７１ｈと固定することが可能となっている円柱形状（例えば、直径５ｍｍ）をしている。そして、送光プローブ１２の内部には、光源２と接続された送光用光ファイバ１４（例えば、直径２ｍｍ）がバネ等を介して固定されており、送光用光ファイバ１４の先端から光が照射されるようになっている。
また、受光プローブ１３も、送光プローブ１２と同様な構造となっており、プローブ装着部１７１ａ〜１７１ｈと固定することが可能となっている円柱形状（例えば、直径５ｍｍ）をしている。そして、受光プローブ１３の内部には、光検出器３と接続された受光用光ファイバ１５（例えば、直径２ｍｍ）がバネ等を介して固定されており、受光用光ファイバ１５の先端から光を受光するようになっている。The light transmission probe 12 has a cylindrical shape (for example, a diameter of 5 mm) that can be fixed to the probe mounting portions 171a to 171h. A light transmission optical fiber 14 (for example, 2 mm in diameter) connected to the light source 2 is fixed inside the light transmission probe 12 via a spring or the like, and light is transmitted from the tip of the light transmission optical fiber 14. Will be irradiated.
The light receiving probe 13 has the same structure as the light transmitting probe 12 and has a cylindrical shape (for example, 5 mm in diameter) that can be fixed to the probe mounting portions 171a to 171h. A light receiving optical fiber 15 (for example, 2 mm in diameter) connected to the photodetector 3 is fixed inside the light receiving probe 13 via a spring or the like, and light is transmitted from the tip of the light receiving optical fiber 15. It is designed to receive light.

ここで、図４（ａ）は、受光プローブ１３が取り付けられたホルダ１６０の第一左側枝部１６１ａの一部の断面図であり、図４（ｂ）は、図４（ａ）に示すホルダ１６０の第一左側枝部１６１ａの裏面図であり、図４（ｃ）は、受光プローブ１３が外されたホルダ１６０の第一左側枝部１６１ａの一部の断面図である。
プローブ装着部１７１ａに形成された円形状の貫通孔の内側には、受光プローブ１３を挿入して固定することが可能となっている。このように対応する番号のプローブ装着部１７１に送光プローブ１２Ｔ１〜１２Ｔ４と受光プローブ１３Ｒ１〜１３Ｒ４とを挿入すれば、図２（ａ）に示すように平面視すると、合計８個（Ｓ１〜Ｓ８）の受光量情報Ａ（λ１）、Ａ（λ２）、Ａ（λ３）の収集を行うことができる。Here, FIG. 4A is a cross-sectional view of a part of the first left branch 161a of the holder 160 to which the light receiving probe 13 is attached, and FIG. 4B is a holder shown in FIG. FIG. 4C is a sectional view of a part of the first left branch 161a of the holder 160 with the light receiving probe 13 removed.
The light receiving probe 13 can be inserted and fixed inside the circular through hole formed in the probe mounting portion 171a. If the light transmitting probes 12 T1 to 12 T4 and the light receiving probes 13 R1 to 13 R4 are inserted into the probe mounting portions 171 having the corresponding numbers as described above, a total of eight probes are obtained in plan view as shown in FIG. The received light amount information A (λ 1 ), A (λ 2 ), and A (λ 3 ) in (S1 to S8) can be collected.

このような基幹部１６２と枝部１６１とプローブ装着部１７１とを構成する材質としては、特に限定されるものではないが、例えば、ポリプロピレン、ポリ塩化ビニル、ポリアセタール、金属等が挙げられる。   There are no particular limitations on the material constituting the trunk portion 162, the branch portion 161, and the probe mounting portion 171, and examples thereof include polypropylene, polyvinyl chloride, polyacetal, and metal.

また、ホルダ１６０には、外部光が受光プローブ１３に入射しないように、黒色の遮光布が取り付けられてもよい。図８（ａ）は、２枚の遮光布８１、８２が取り付けられたホルダ１６０の平面図であり、図８（ｂ）は、遮光布８１が取り付けられたホルダ１６０の一部の断面図である。遮光布８１は、厚さ２ｍｍの平行四辺形をしており、遮光布８１には、４個のプローブ装着部１７１に対応する４個の穴８１ａが形成されている。このような遮光布８１は、ホルダ１６０の下面に、４個の穴８１ａに４個のプローブ装着部１７１を貫通させるようにして取り付けられる。また、遮光布８２も、同様な構造となっている。   Further, a black light shielding cloth may be attached to the holder 160 so that external light does not enter the light receiving probe 13. 8A is a plan view of the holder 160 to which the two light shielding cloths 81 and 82 are attached, and FIG. 8B is a cross-sectional view of a part of the holder 160 to which the light shielding cloth 81 is attached. is there. The light shielding cloth 81 has a parallelogram shape with a thickness of 2 mm, and four holes 81 a corresponding to the four probe mounting portions 171 are formed in the light shielding cloth 81. Such a light shielding cloth 81 is attached to the lower surface of the holder 160 so that the four probe mounting portions 171 pass through the four holes 81a. The light shielding cloth 82 has a similar structure.

さらに、ホルダ１６０には、形成された第一の平行四辺形や第二の平行四辺形が変形しないように、固定部材が取り付けられてもよい。図９（ａ）は、８個の固定部材９０が取り付けられたホルダ１６０の平面図であり、図９（ｂ）は、固定部材９０が取り付けられたホルダ１６０の一部の断面図である。固定部材９０は、一の字形状の板状体とし、そして、固定部材９０は、両端に円環形状の挿入部と、両端の挿入部を設定距離で連結する連結部とを有する。各挿入部の中央には、プローブ装着部１７１が挿入されるための円形状の貫通孔がそれぞれ開けられている。また、連結部は、幅１０ｍｍ、厚さ０．１ｍｍであり、かつ、貫通孔の中心と貫通孔の中心との間の距離が設定距離３１．５ｍｍとなるように形成され、厚さ方向にだけ可撓性を有する。つまり、両端の挿入部は、常にチャンネル長さＸ（３０ｍｍ）で保持されるようになっている。そして、ホルダ１６０の下面に、２個の連結部に２個のプローブ装着部１７１を貫通させるようにして取り付けられる。
なお、固定部材９０や遮光布８２は薄く形成されており、固定部材９０や遮光布８２が取り付けられても、プローブ装着部１７１の下端部は、固定部材９０や遮光布８２の下面から突出するようになっている。Furthermore, a fixing member may be attached to the holder 160 so that the formed first parallelogram and second parallelogram are not deformed. FIG. 9A is a plan view of the holder 160 to which the eight fixing members 90 are attached, and FIG. 9B is a cross-sectional view of a part of the holder 160 to which the fixing members 90 are attached. The fixing member 90 is a plate-shaped body having a single letter shape, and the fixing member 90 has annular insertion portions at both ends and connecting portions that connect the insertion portions at both ends with a set distance. In the center of each insertion portion, a circular through hole for inserting the probe mounting portion 171 is opened. The connecting portion has a width of 10 mm and a thickness of 0.1 mm, and is formed such that the distance between the center of the through hole and the center of the through hole is a set distance of 31.5 mm. Only flexible. That is, the insertion portions at both ends are always held at the channel length X (30 mm). And it attaches to the lower surface of the holder 160 so that the two probe mounting parts 171 may penetrate the two connection parts.
The fixing member 90 and the light shielding cloth 82 are formed thin, and even if the fixing member 90 and the light shielding cloth 82 are attached, the lower end portion of the probe mounting portion 171 protrudes from the lower surface of the fixing member 90 and the light shielding cloth 82. It is like that.

このような光計測装置１によれば、まず、被検者は、送光プローブ１２Ｔ１〜１２Ｔ４と受光プローブ１３Ｒ１〜１３Ｒ４とをホルダ１６０のプローブ装着部１７１の貫通孔に所定の配列で挿入する。次に、被検者は、ホルダ１６０の下面に遮光布８１、８２や固定部材９０を装着する。そして、被検者は、ホルダ１６０を頭部の前方から頭部の後方へ向かって、プローブ装着部１７１で毛髪を掻き分けながら挿入するように頭部に配置する。According to such an optical measurement device 1, first, the subject arranges the light transmitting probes 12 T1 to 12 T4 and the light receiving probes 13 R1 to 13 R4 in a predetermined arrangement in the through hole of the probe mounting portion 171 of the holder 160. Insert with. Next, the subject wears the light shielding cloths 81 and 82 and the fixing member 90 on the lower surface of the holder 160. Then, the subject places the holder 160 on the head from the front of the head toward the rear of the head so as to insert the hair while scraping the hair with the probe mounting portion 171.

以上のように、本発明の光計測システム１によれば、被検者一人でも自分自身の頭部に短時間で容易にホルダ１６０を装着することができる。   As described above, according to the optical measurement system 1 of the present invention, even one subject can easily attach the holder 160 to his / her head in a short time.

＜他の実施形態＞
（１）上述した光計測装置１では、ホルダ１６０を頭部の前方から頭部の後方に向かって頭部に装着していくような構成としたが、ホルダを頭部の右方から頭部の左方に向かって頭部に装着していくような構成としてもよい。
（２）上述した光計測装置１では、ホルダ１６０に４個の送光プローブ１２Ｔ１〜１２Ｔ４と４個の受光プローブ１３Ｒ１〜１３Ｒ４とを取り付けるような構成としたが、ホルダに８個の送光プローブと８個の受光プローブとを取り付けるような構成としてもよく、ホルダに２個の送光プローブと２個の受光プローブとを取り付けるような構成としてもよい。<Other embodiments>
(1) In the optical measuring device 1 described above, the holder 160 is mounted on the head from the front of the head toward the rear of the head. It is good also as a structure which mounts | wears with a head toward the left side.
(2) In the optical measuring device 1 described above, the holder 160 is configured to attach the four light transmitting probes 12 T1 to 12 T4 and the four light receiving probes 13 R1 to 13 R4. The light transmitting probe and eight light receiving probes may be attached, or two light transmitting probes and two light receiving probes may be attached to the holder.

本発明は、生体内部に光を照射して生体内部情報を取得する光計測装置等に利用することができる。   INDUSTRIAL APPLICABILITY The present invention can be used for an optical measurement device that irradiates light inside a living body and acquires information inside the living body.

１：光計測装置
１１：筐体
１２：送光プローブ
１３：受光プローブ
１４：送光用光ファイバ
１５：受光用光ファイバ
２２：解析用制御部
２６：表示装置
２７：キーボード（入力装置）
１６０：ホルダ
１６１：枝部
１６２：基幹部
１７１：プローブ装着部1: optical measuring device 11: housing 12: light transmitting probe 13: light receiving probe 14: light transmitting optical fiber 15: light receiving optical fiber 22: analysis control unit 26: display device 27: keyboard (input device)
160: Holder 161: Branch part 162: Main part 171: Probe mounting part

Claims (6)

少なくとも２個のプローブ装着部を有し、当該プローブ装着部に先端から光を照射する送光プローブ、又は、先端から光を受光する受光プローブが挿入されて、被検者の頭部に装着されるホルダであって、
第一方向に伸びた直線状の基幹部と、
前記第一方向と異なる第二方向に伸びた少なくとも２本の直線状の枝部とを備え、
前記第二方向から毛髪を掻き分けながら挿入していくことが可能な櫛型形状となっており、
前記プローブ装着部は、前記枝部の先端に形成されていることを特徴とするホルダ。 It has at least two probe mounting parts, and a light-transmitting probe that emits light from the tip or a light-receiving probe that receives light from the tip is inserted into the probe mounting part, and is attached to the head of the subject. A holder,
A linear backbone extending in the first direction;
Comprising at least two straight branches extending in a second direction different from the first direction,
Comb shape that can be inserted while scraping the hair from the second direction,
The probe mounting part is formed at the tip of the branch part. 前記プローブ装着部は、前記送光プローブ又は受光プローブが挿入される貫通孔を有し、
前記プローブ装着部の下端部が、前記枝部の下面から突出していることを特徴とする請求項１に記載のホルダ。The probe mounting part has a through hole into which the light transmitting probe or the light receiving probe is inserted,
The holder according to claim 1, wherein a lower end portion of the probe mounting portion protrudes from a lower surface of the branch portion. 前記プローブ装着部の下端部が、下方から視ると、円環形状となっていることを特徴とする請求項２に記載のホルダ。   The holder according to claim 2, wherein a lower end portion of the probe mounting portion has an annular shape when viewed from below. 前記プローブ装着部に対応する位置に穴が形成された遮光布を備え、
前記穴に前記プローブ装着部を貫通させるようにして前記遮光布が取り付けられることを特徴とする請求項１〜請求項３のいずかに記載のホルダ。A light shielding cloth having a hole formed at a position corresponding to the probe mounting portion;
The holder according to any one of claims 1 to 3, wherein the light shielding cloth is attached so as to penetrate the probe mounting portion through the hole. 両端に挿入部と、両端の挿入部を設定距離で連結する連結部とを有する固定部材を備え、
各挿入部には、前記プローブ装着部が挿入されるための貫通孔がそれぞれ開けられており、
前記貫通孔に前記プローブ装着部を貫通させるようにして前記固定部材が取り付けられることを特徴とする請求項１〜請求項４のいずかに記載のホルダ。A fixing member having an insertion portion at both ends and a connecting portion for connecting the insertion portions at both ends at a set distance,
Each insertion part has a through-hole for inserting the probe mounting part,
The holder according to any one of claims 1 to 4, wherein the fixing member is attached so as to penetrate the probe mounting portion through the through hole. 請求項１〜請求項５のいずかに記載のホルダと、
前記被検者に光を照射する送光プローブと、
前記被検者から放出される光を受光する受光プローブと、
前記送光プローブ及び受光プローブを制御することで、前記被検者の脳活動に関する測定データを得る制御部とを備えることを特徴とする光計測装置。A holder according to any one of claims 1 to 5;
A light transmission probe for irradiating the subject with light;
A light receiving probe that receives light emitted from the subject; and
An optical measurement apparatus comprising: a control unit that obtains measurement data related to the brain activity of the subject by controlling the light transmitting probe and the light receiving probe.
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