WO2011069590A1 - Therapeutic and cosmetic electroluminescent compositions - Google Patents
Therapeutic and cosmetic electroluminescent compositions Download PDFInfo
- Publication number
- WO2011069590A1 WO2011069590A1 PCT/EP2010/006874 EP2010006874W WO2011069590A1 WO 2011069590 A1 WO2011069590 A1 WO 2011069590A1 EP 2010006874 W EP2010006874 W EP 2010006874W WO 2011069590 A1 WO2011069590 A1 WO 2011069590A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- prophylaxis
- skin
- composition according
- diseases
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 214
- 239000002537 cosmetic Substances 0.000 title claims abstract description 55
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 45
- 238000011282 treatment Methods 0.000 claims abstract description 137
- 150000001875 compounds Chemical class 0.000 claims abstract description 95
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 67
- 201000010099 disease Diseases 0.000 claims abstract description 63
- 238000011321 prophylaxis Methods 0.000 claims abstract description 59
- 238000009472 formulation Methods 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims description 96
- 206010000496 acne Diseases 0.000 claims description 67
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 56
- 238000002360 preparation method Methods 0.000 claims description 32
- 206010023126 Jaundice Diseases 0.000 claims description 25
- 238000002428 photodynamic therapy Methods 0.000 claims description 22
- 201000004624 Dermatitis Diseases 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 16
- 208000017520 skin disease Diseases 0.000 claims description 15
- 239000011505 plaster Substances 0.000 claims description 14
- 208000035484 Cellulite Diseases 0.000 claims description 12
- 206010030113 Oedema Diseases 0.000 claims description 12
- 206010049752 Peau d'orange Diseases 0.000 claims description 12
- 201000004681 Psoriasis Diseases 0.000 claims description 12
- 230000036232 cellulite Effects 0.000 claims description 12
- 206010047642 Vitiligo Diseases 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 11
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 201000008937 atopic dermatitis Diseases 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 208000010668 atopic eczema Diseases 0.000 claims description 9
- 230000002757 inflammatory effect Effects 0.000 claims description 9
- 235000013361 beverage Nutrition 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 6
- 230000000926 neurological effect Effects 0.000 claims description 6
- 230000035764 nutrition Effects 0.000 claims description 6
- 235000016709 nutrition Nutrition 0.000 claims description 6
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims description 4
- 125000002524 organometallic group Chemical group 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 206010027476 Metastases Diseases 0.000 claims description 3
- 208000009621 actinic keratosis Diseases 0.000 claims description 3
- 208000006934 radiodermatitis Diseases 0.000 claims description 3
- 206010003139 Arsenical keratosis Diseases 0.000 claims description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 2
- 208000013165 Bowen disease Diseases 0.000 claims description 2
- 208000019337 Bowen disease of the skin Diseases 0.000 claims description 2
- 230000005670 electromagnetic radiation Effects 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 80
- -1 poly(p-phenylene vinylene) Polymers 0.000 description 79
- 229920000642 polymer Polymers 0.000 description 76
- 239000010410 layer Substances 0.000 description 34
- 238000001126 phototherapy Methods 0.000 description 31
- 230000032683 aging Effects 0.000 description 30
- 229910052751 metal Inorganic materials 0.000 description 30
- 239000002184 metal Substances 0.000 description 30
- 238000000034 method Methods 0.000 description 30
- 125000003118 aryl group Chemical group 0.000 description 29
- 125000004432 carbon atom Chemical group C* 0.000 description 27
- 239000003814 drug Substances 0.000 description 25
- 229940079593 drug Drugs 0.000 description 21
- 201000004700 rosacea Diseases 0.000 description 20
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 18
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 18
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 17
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- 208000027418 Wounds and injury Diseases 0.000 description 15
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Natural products C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 15
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 15
- 229910052741 iridium Inorganic materials 0.000 description 15
- 239000002019 doping agent Substances 0.000 description 14
- 239000000758 substrate Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 13
- 206010061218 Inflammation Diseases 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 13
- 241001303601 Rosacea Species 0.000 description 13
- 206010052428 Wound Diseases 0.000 description 13
- 238000005538 encapsulation Methods 0.000 description 13
- 230000006870 function Effects 0.000 description 13
- 230000004054 inflammatory process Effects 0.000 description 13
- 229930192474 thiophene Natural products 0.000 description 13
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- ICPSWZFVWAPUKF-UHFFFAOYSA-N 1,1'-spirobi[fluorene] Chemical class C1=CC=C2C=C3C4(C=5C(C6=CC=CC=C6C=5)=CC=C4)C=CC=C3C2=C1 ICPSWZFVWAPUKF-UHFFFAOYSA-N 0.000 description 11
- 241000282412 Homo Species 0.000 description 11
- 206010040954 Skin wrinkling Diseases 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 11
- 239000011159 matrix material Substances 0.000 description 11
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 11
- 241000894007 species Species 0.000 description 11
- 125000005259 triarylamine group Chemical group 0.000 description 11
- 150000001454 anthracenes Chemical class 0.000 description 10
- 229920000547 conjugated polymer Polymers 0.000 description 10
- 229920001577 copolymer Polymers 0.000 description 10
- 229910052736 halogen Inorganic materials 0.000 description 10
- 150000002367 halogens Chemical class 0.000 description 10
- 229910052763 palladium Inorganic materials 0.000 description 10
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 10
- 229920003207 poly(ethylene-2,6-naphthalate) Polymers 0.000 description 10
- 239000011112 polyethylene naphthalate Substances 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 239000010409 thin film Substances 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 150000001716 carbazoles Chemical class 0.000 description 9
- 239000003446 ligand Substances 0.000 description 9
- 150000002739 metals Chemical class 0.000 description 9
- 229920003023 plastic Polymers 0.000 description 9
- 239000004033 plastic Substances 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 230000032258 transport Effects 0.000 description 9
- 150000001412 amines Chemical class 0.000 description 8
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 8
- 239000000412 dendrimer Substances 0.000 description 8
- 229920000736 dendritic polymer Polymers 0.000 description 8
- 150000002220 fluorenes Chemical class 0.000 description 8
- PJULCNAVAGQLAT-UHFFFAOYSA-N indeno[2,1-a]fluorene Chemical class C1=CC=C2C=C3C4=CC5=CC=CC=C5C4=CC=C3C2=C1 PJULCNAVAGQLAT-UHFFFAOYSA-N 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 150000002576 ketones Chemical class 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 230000004060 metabolic process Effects 0.000 description 8
- 229910052762 osmium Inorganic materials 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 229910052697 platinum Inorganic materials 0.000 description 8
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 8
- 150000003384 small molecules Chemical class 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 8
- 230000007704 transition Effects 0.000 description 8
- 229910052723 transition metal Inorganic materials 0.000 description 8
- 150000003624 transition metals Chemical class 0.000 description 8
- 230000037303 wrinkles Effects 0.000 description 8
- POILWHVDKZOXJZ-ARJAWSKDSA-M (z)-4-oxopent-2-en-2-olate Chemical compound C\C([O-])=C\C(C)=O POILWHVDKZOXJZ-ARJAWSKDSA-M 0.000 description 7
- DXBHBZVCASKNBY-UHFFFAOYSA-N 1,2-Benz(a)anthracene Chemical class C1=CC=C2C3=CC4=CC=CC=C4C=C3C=CC2=C1 DXBHBZVCASKNBY-UHFFFAOYSA-N 0.000 description 7
- 239000007983 Tris buffer Substances 0.000 description 7
- 241000700605 Viruses Species 0.000 description 7
- 150000004982 aromatic amines Chemical class 0.000 description 7
- 229960001701 chloroform Drugs 0.000 description 7
- 125000004093 cyano group Chemical group *C#N 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 210000001508 eye Anatomy 0.000 description 7
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 7
- 150000003254 radicals Chemical class 0.000 description 7
- 208000012672 seasonal affective disease Diseases 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 7
- 150000003577 thiophenes Chemical class 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 230000000699 topical effect Effects 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 description 6
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 6
- 150000001450 anions Chemical class 0.000 description 6
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 6
- 150000001768 cations Chemical class 0.000 description 6
- 230000001413 cellular effect Effects 0.000 description 6
- 229910052802 copper Inorganic materials 0.000 description 6
- 239000011888 foil Substances 0.000 description 6
- 230000005525 hole transport Effects 0.000 description 6
- VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical compound C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 description 6
- 229960005544 indolocarbazole Drugs 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 6
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 238000012552 review Methods 0.000 description 6
- 229910052703 rhodium Inorganic materials 0.000 description 6
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 6
- 150000003918 triazines Chemical class 0.000 description 6
- UWRZIZXBOLBCON-VOTSOKGWSA-N (e)-2-phenylethenamine Chemical class N\C=C\C1=CC=CC=C1 UWRZIZXBOLBCON-VOTSOKGWSA-N 0.000 description 5
- UWRZIZXBOLBCON-UHFFFAOYSA-N 2-phenylethenamine Chemical class NC=CC1=CC=CC=C1 UWRZIZXBOLBCON-UHFFFAOYSA-N 0.000 description 5
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 5
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 5
- 208000002782 Acneiform Eruptions Diseases 0.000 description 5
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 5
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 5
- 208000004631 alopecia areata Diseases 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 229940077464 ammonium ion Drugs 0.000 description 5
- 125000005577 anthracene group Chemical group 0.000 description 5
- 238000000231 atomic layer deposition Methods 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 150000004696 coordination complex Chemical class 0.000 description 5
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 5
- 239000010408 film Substances 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- WUNJCKOTXFSWBK-UHFFFAOYSA-N indeno[2,1-a]carbazole Chemical compound C1=CC=C2C=C3C4=NC5=CC=CC=C5C4=CC=C3C2=C1 WUNJCKOTXFSWBK-UHFFFAOYSA-N 0.000 description 5
- 208000027866 inflammatory disease Diseases 0.000 description 5
- 239000010416 ion conductor Substances 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 210000004877 mucosa Anatomy 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229920003227 poly(N-vinyl carbazole) Polymers 0.000 description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 description 5
- 239000005020 polyethylene terephthalate Substances 0.000 description 5
- 150000004032 porphyrins Chemical class 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 229910052707 ruthenium Inorganic materials 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 235000021286 stilbenes Nutrition 0.000 description 5
- 125000005504 styryl group Chemical group 0.000 description 5
- 238000011269 treatment regimen Methods 0.000 description 5
- TVIVIEFSHFOWTE-UHFFFAOYSA-K tri(quinolin-8-yloxy)alumane Chemical compound [Al+3].C1=CN=C2C([O-])=CC=CC2=C1.C1=CN=C2C([O-])=CC=CC2=C1.C1=CN=C2C([O-])=CC=CC2=C1 TVIVIEFSHFOWTE-UHFFFAOYSA-K 0.000 description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 5
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 4
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 4
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 4
- 208000032544 Cicatrix Diseases 0.000 description 4
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- 206010016936 Folliculitis Diseases 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 4
- 201000006346 Neonatal Jaundice Diseases 0.000 description 4
- 208000009675 Perioral Dermatitis Diseases 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 4
- 206010039580 Scar Diseases 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- WDECIBYCCFPHNR-UHFFFAOYSA-N chrysene Chemical compound C1=CC=CC2=CC=C3C4=CC=CC=C4C=CC3=C21 WDECIBYCCFPHNR-UHFFFAOYSA-N 0.000 description 4
- VPUGDVKSAQVFFS-UHFFFAOYSA-N coronene Chemical compound C1=C(C2=C34)C=CC3=CC=C(C=C3)C4=C4C3=CC=C(C=C3)C4=C2C3=C1 VPUGDVKSAQVFFS-UHFFFAOYSA-N 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 210000004177 elastic tissue Anatomy 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 4
- 230000009477 glass transition Effects 0.000 description 4
- 230000002440 hepatic effect Effects 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000000282 nail Anatomy 0.000 description 4
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 4
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 4
- 150000002987 phenanthrenes Chemical class 0.000 description 4
- 229920000553 poly(phenylenevinylene) Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 229910052702 rhenium Inorganic materials 0.000 description 4
- YYMBJDOZVAITBP-UHFFFAOYSA-N rubrene Chemical class C1=CC=CC=C1C(C1=C(C=2C=CC=CC=2)C2=CC=CC=C2C(C=2C=CC=CC=2)=C11)=C(C=CC=C2)C2=C1C1=CC=CC=C1 YYMBJDOZVAITBP-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 238000004528 spin coating Methods 0.000 description 4
- 238000010561 standard procedure Methods 0.000 description 4
- 150000003462 sulfoxides Chemical class 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- OVTCUIZCVUGJHS-VQHVLOKHSA-N trans-dipyrrin Chemical compound C=1C=CNC=1/C=C1\C=CC=N1 OVTCUIZCVUGJHS-VQHVLOKHSA-N 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 229910052725 zinc Inorganic materials 0.000 description 4
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 3
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 description 3
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 3
- LTUJKAYZIMMJEP-UHFFFAOYSA-N 9-[4-(4-carbazol-9-yl-2-methylphenyl)-3-methylphenyl]carbazole Chemical compound C12=CC=CC=C2C2=CC=CC=C2N1C1=CC=C(C=2C(=CC(=CC=2)N2C3=CC=CC=C3C3=CC=CC=C32)C)C(C)=C1 LTUJKAYZIMMJEP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 206010051651 Dermatitis papillaris capillitii Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 229910052693 Europium Inorganic materials 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 3
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 3
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 3
- 241000701806 Human papillomavirus Species 0.000 description 3
- 206010023129 Jaundice cholestatic Diseases 0.000 description 3
- 206010023138 Jaundice neonatal Diseases 0.000 description 3
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 3
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 3
- 208000000112 Myalgia Diseases 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 206010054107 Nodule Diseases 0.000 description 3
- 201000005267 Obstructive Jaundice Diseases 0.000 description 3
- 206010033733 Papule Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 3
- 229920001609 Poly(3,4-ethylenedioxythiophene) Polymers 0.000 description 3
- NRCMAYZCPIVABH-UHFFFAOYSA-N Quinacridone Chemical compound N1C2=CC=CC=C2C(=O)C2=C1C=C1C(=O)C3=CC=CC=C3NC1=C2 NRCMAYZCPIVABH-UHFFFAOYSA-N 0.000 description 3
- 229910006080 SO2X Inorganic materials 0.000 description 3
- 229910052581 Si3N4 Inorganic materials 0.000 description 3
- 208000000453 Skin Neoplasms Diseases 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 3
- 229910052768 actinide Inorganic materials 0.000 description 3
- 150000001255 actinides Chemical class 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 235000010290 biphenyl Nutrition 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical group [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 210000001953 common bile duct Anatomy 0.000 description 3
- 239000002322 conducting polymer Substances 0.000 description 3
- 229920001940 conductive polymer Polymers 0.000 description 3
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 125000004986 diarylamino group Chemical group 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 210000004904 fingernail bed Anatomy 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 201000007162 hidradenitis suppurativa Diseases 0.000 description 3
- 238000004770 highest occupied molecular orbital Methods 0.000 description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 150000002460 imidazoles Chemical class 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000011229 interlayer Substances 0.000 description 3
- 150000008040 ionic compounds Chemical class 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 229960005280 isotretinoin Drugs 0.000 description 3
- 229910052747 lanthanoid Inorganic materials 0.000 description 3
- 150000002602 lanthanoids Chemical class 0.000 description 3
- 238000004768 lowest unoccupied molecular orbital Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 3
- 229960003987 melatonin Drugs 0.000 description 3
- 229960004469 methoxsalen Drugs 0.000 description 3
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 3
- 230000037230 mobility Effects 0.000 description 3
- 229910052750 molybdenum Inorganic materials 0.000 description 3
- 230000036651 mood Effects 0.000 description 3
- 201000005962 mycosis fungoides Diseases 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000013021 overheating Methods 0.000 description 3
- 229960003540 oxyquinoline Drugs 0.000 description 3
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 3
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 229920000767 polyaniline Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 229920000123 polythiophene Polymers 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 3
- 230000003716 rejuvenation Effects 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 208000014745 severe cutaneous adverse reaction Diseases 0.000 description 3
- 229910052814 silicon oxide Inorganic materials 0.000 description 3
- 101150075118 sub1 gene Proteins 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 150000003518 tetracenes Chemical class 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- YGLVWOUNCXBPJF-UHFFFAOYSA-N (2,3,4,5-tetraphenylcyclopenta-1,4-dien-1-yl)benzene Chemical compound C1=CC=CC=C1C1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 YGLVWOUNCXBPJF-UHFFFAOYSA-N 0.000 description 2
- JCXLYAWYOTYWKM-UHFFFAOYSA-N (2,3,4-triphenylcyclopenta-1,3-dien-1-yl)benzene Chemical compound C1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 JCXLYAWYOTYWKM-UHFFFAOYSA-N 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 2
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 2
- OZKOMUDCMCEDTM-UHFFFAOYSA-N 1,7-phenanthroline Chemical group C1=CC=C2C3=NC=CC=C3C=CC2=N1 OZKOMUDCMCEDTM-UHFFFAOYSA-N 0.000 description 2
- UHXOHPVVEHBKKT-UHFFFAOYSA-N 1-(2,2-diphenylethenyl)-4-[4-(2,2-diphenylethenyl)phenyl]benzene Chemical group C=1C=C(C=2C=CC(C=C(C=3C=CC=CC=3)C=3C=CC=CC=3)=CC=2)C=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 UHXOHPVVEHBKKT-UHFFFAOYSA-N 0.000 description 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 2
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 2
- ZOKIJILZFXPFTO-UHFFFAOYSA-N 4-methyl-n-[4-[1-[4-(4-methyl-n-(4-methylphenyl)anilino)phenyl]cyclohexyl]phenyl]-n-(4-methylphenyl)aniline Chemical compound C1=CC(C)=CC=C1N(C=1C=CC(=CC=1)C1(CCCCC1)C=1C=CC(=CC=1)N(C=1C=CC(C)=CC=1)C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 ZOKIJILZFXPFTO-UHFFFAOYSA-N 0.000 description 2
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 2
- 150000004325 8-hydroxyquinolines Chemical class 0.000 description 2
- ZHBOFZNNPZNWGB-UHFFFAOYSA-N 9,10-bis(phenylethynyl)anthracene Chemical class C1=CC=CC=C1C#CC(C1=CC=CC=C11)=C(C=CC=C2)C2=C1C#CC1=CC=CC=C1 ZHBOFZNNPZNWGB-UHFFFAOYSA-N 0.000 description 2
- MZYDBGLUVPLRKR-UHFFFAOYSA-N 9-(3-carbazol-9-ylphenyl)carbazole Chemical compound C12=CC=CC=C2C2=CC=CC=C2N1C1=CC(N2C3=CC=CC=C3C3=CC=CC=C32)=CC=C1 MZYDBGLUVPLRKR-UHFFFAOYSA-N 0.000 description 2
- ZHQCITRPEYURRL-UHFFFAOYSA-N 9-ethynyl-1-[4-(9-ethynylanthracen-1-yl)phenyl]anthracene Chemical compound C1=CC=C2C(C#C)=C3C(C4=CC=C(C=C4)C=4C=CC=C5C=C6C=CC=CC6=C(C=45)C#C)=CC=CC3=CC2=C1 ZHQCITRPEYURRL-UHFFFAOYSA-N 0.000 description 2
- 206010000507 Acne infantile Diseases 0.000 description 2
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- 239000004342 Benzoyl peroxide Substances 0.000 description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical compound CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 2
- 0 CC1C=C(C(*)(*)c2cc(-c3c(C4(C)*)cc(C)cc3)c4cc22)C2=CC1 Chemical compound CC1C=C(C(*)(*)c2cc(-c3c(C4(C)*)cc(C)cc3)c4cc22)C2=CC1 0.000 description 2
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 2
- 206010011684 Cutaneous tuberculosis Diseases 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 229910052692 Dysprosium Inorganic materials 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000531123 GB virus C Species 0.000 description 2
- 229910052688 Gadolinium Inorganic materials 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 241000724675 Hepatitis E virus Species 0.000 description 2
- 208000037262 Hepatitis delta Diseases 0.000 description 2
- 241000724709 Hepatitis delta virus Species 0.000 description 2
- 241000709721 Hepatovirus A Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 2
- SXFPNMRWIWIAGS-UHFFFAOYSA-N Khellin Natural products COC1C2CCOC2C(OC)C3OC(C)CC(=O)C13 SXFPNMRWIWIAGS-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 2
- LYPFDBRUNKHDGX-SOGSVHMOSA-N N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 Chemical compound N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 LYPFDBRUNKHDGX-SOGSVHMOSA-N 0.000 description 2
- 206010028836 Neck pain Diseases 0.000 description 2
- 206010029098 Neoplasm skin Diseases 0.000 description 2
- 208000007256 Nevus Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical group CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 238000009193 PUVA therapy Methods 0.000 description 2
- 241001631646 Papillomaviridae Species 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 206010036087 Polymorphic light eruption Diseases 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 206010037888 Rash pustular Diseases 0.000 description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 2
- 229910004205 SiNX Inorganic materials 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 229910052771 Terbium Inorganic materials 0.000 description 2
- XBDYBAVJXHJMNQ-UHFFFAOYSA-N Tetrahydroanthracene Natural products C1=CC=C2C=C(CCCC3)C3=CC2=C1 XBDYBAVJXHJMNQ-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 206010044725 Tuberculid Diseases 0.000 description 2
- 208000000260 Warts Diseases 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- OGQICQVSFDPSEI-UHFFFAOYSA-N Zorac Chemical compound N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1 OGQICQVSFDPSEI-UHFFFAOYSA-N 0.000 description 2
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000006193 alkinyl group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 150000001556 benzimidazoles Chemical class 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- 208000027119 bilirubin metabolic disease Diseases 0.000 description 2
- 239000004305 biphenyl Substances 0.000 description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000013626 chemical specie Substances 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 150000001851 cinnamic acid derivatives Chemical class 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 208000018631 connective tissue disease Diseases 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 2
- 229960003843 cyproterone Drugs 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- CUIWZLHUNCCYBL-UHFFFAOYSA-N decacyclene Chemical compound C12=C([C]34)C=CC=C4C=CC=C3C2=C2C(=C34)C=C[CH]C4=CC=CC3=C2C2=C1C1=CC=CC3=CC=CC2=C31 CUIWZLHUNCCYBL-UHFFFAOYSA-N 0.000 description 2
- NNBZCPXTIHJBJL-UHFFFAOYSA-N decalin Chemical compound C1CCCC2CCCCC21 NNBZCPXTIHJBJL-UHFFFAOYSA-N 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- XNKVIGSNRYAOQZ-UHFFFAOYSA-N dibenzofluorene Chemical compound C12=CC=CC=C2C2=CC=CC=C2C2=C1CC1=CC=CC=C12 XNKVIGSNRYAOQZ-UHFFFAOYSA-N 0.000 description 2
- IYYZUPMFVPLQIF-UHFFFAOYSA-N dibenzothiophene Chemical compound C1=CC=C2C3=CC=CC=C3SC2=C1 IYYZUPMFVPLQIF-UHFFFAOYSA-N 0.000 description 2
- BKMIWBZIQAAZBD-UHFFFAOYSA-N diindenoperylene Chemical compound C12=C3C4=CC=C2C2=CC=CC=C2C1=CC=C3C1=CC=C2C3=CC=CC=C3C3=CC=C4C1=C32 BKMIWBZIQAAZBD-UHFFFAOYSA-N 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 208000011318 facial edema Diseases 0.000 description 2
- 150000008376 fluorenones Chemical class 0.000 description 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- UQSQSQZYBQSBJZ-UHFFFAOYSA-N fluorosulfonic acid Chemical compound OS(F)(=O)=O UQSQSQZYBQSBJZ-UHFFFAOYSA-N 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 239000000446 fuel Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 208000016361 genetic disease Diseases 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- WIAWDMBHXUZQGV-UHFFFAOYSA-N heptacyclo[13.10.1.12,6.011,26.017,25.018,23.010,27]heptacosa-1(25),2,4,6(27),7,9,11,13,15(26),17,19,21,23-tridecaene Chemical group C=12C3=CC=CC2=CC=CC=1C1=CC=CC2=C1C3=C1C=C3C=CC=CC3=C1C2 WIAWDMBHXUZQGV-UHFFFAOYSA-N 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 150000007857 hydrazones Chemical class 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 208000036796 hyperbilirubinemia Diseases 0.000 description 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- HSMPDPBYAYSOBC-UHFFFAOYSA-N khellin Chemical compound O1C(C)=CC(=O)C2=C1C(OC)=C1OC=CC1=C2OC HSMPDPBYAYSOBC-UHFFFAOYSA-N 0.000 description 2
- 229960002801 khellin Drugs 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 201000011486 lichen planus Diseases 0.000 description 2
- IMKMFBIYHXBKRX-UHFFFAOYSA-M lithium;quinoline-2-carboxylate Chemical compound [Li+].C1=CC=CC2=NC(C(=O)[O-])=CC=C21 IMKMFBIYHXBKRX-UHFFFAOYSA-M 0.000 description 2
- IVSZLXZYQVIEFR-UHFFFAOYSA-N m-xylene Chemical group CC1=CC=CC(C)=C1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- WYNCDLDEWVNKJX-UHFFFAOYSA-M methyl(trioctyl)azanium;trifluoromethanesulfonate Chemical compound [O-]S(=O)(=O)C(F)(F)F.CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC WYNCDLDEWVNKJX-UHFFFAOYSA-M 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 229960004023 minocycline Drugs 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 208000013465 muscle pain Diseases 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229940127249 oral antibiotic Drugs 0.000 description 2
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 description 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 2
- 150000005041 phenanthrolines Chemical class 0.000 description 2
- 125000001791 phenazinyl group Chemical class C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 150000004986 phenylenediamines Chemical class 0.000 description 2
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 229920001643 poly(ether ketone) Polymers 0.000 description 2
- 229920000548 poly(silane) polymer Polymers 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920002480 polybenzimidazole Polymers 0.000 description 2
- 229920006393 polyether sulfone Polymers 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920006389 polyphenyl polymer Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
- 230000009290 primary effect Effects 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 230000001185 psoriatic effect Effects 0.000 description 2
- 208000029561 pustule Diseases 0.000 description 2
- 150000003220 pyrenes Chemical class 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 150000003222 pyridines Chemical class 0.000 description 2
- FYNROBRQIVCIQF-UHFFFAOYSA-N pyrrolo[3,2-b]pyrrole-5,6-dione Chemical compound C1=CN=C2C(=O)C(=O)N=C21 FYNROBRQIVCIQF-UHFFFAOYSA-N 0.000 description 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 2
- 239000003642 reactive oxygen metabolite Substances 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- MABNMNVCOAICNO-UHFFFAOYSA-N selenophene Chemical compound C=1C=C[se]C=1 MABNMNVCOAICNO-UHFFFAOYSA-N 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 239000005266 side chain polymer Substances 0.000 description 2
- 150000004756 silanes Chemical class 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 125000003003 spiro group Chemical group 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 150000003457 sulfones Chemical class 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 229960002197 temoporfin Drugs 0.000 description 2
- 150000003512 tertiary amines Chemical group 0.000 description 2
- IFLREYGFSNHWGE-UHFFFAOYSA-N tetracene Chemical compound C1=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C21 IFLREYGFSNHWGE-UHFFFAOYSA-N 0.000 description 2
- 229940040944 tetracyclines Drugs 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- IBBLKSWSCDAPIF-UHFFFAOYSA-N thiopyran Chemical compound S1C=CC=C=C1 IBBLKSWSCDAPIF-UHFFFAOYSA-N 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 210000002105 tongue Anatomy 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- FMHHVULEAZTJMA-UHFFFAOYSA-N trioxsalen Chemical compound CC1=CC(=O)OC2=C1C=C1C=C(C)OC1=C2C FMHHVULEAZTJMA-UHFFFAOYSA-N 0.000 description 2
- 229910052720 vanadium Inorganic materials 0.000 description 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- DMDOIBWPFWJPQJ-ONEGZZNKSA-N (e)-2,3-bis(sulfanyl)but-2-enedinitrile Chemical compound N#CC(/S)=C(\S)C#N DMDOIBWPFWJPQJ-ONEGZZNKSA-N 0.000 description 1
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
- ZXMGHDIOOHOAAE-UHFFFAOYSA-N 1,1,1-trifluoro-n-(trifluoromethylsulfonyl)methanesulfonamide Chemical compound FC(F)(F)S(=O)(=O)NS(=O)(=O)C(F)(F)F ZXMGHDIOOHOAAE-UHFFFAOYSA-N 0.000 description 1
- 150000005045 1,10-phenanthrolines Chemical class 0.000 description 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- NGQSLSMAEVWNPU-YTEMWHBBSA-N 1,2-bis[(e)-2-phenylethenyl]benzene Chemical compound C=1C=CC=CC=1/C=C/C1=CC=CC=C1\C=C\C1=CC=CC=C1 NGQSLSMAEVWNPU-YTEMWHBBSA-N 0.000 description 1
- 150000005072 1,3,4-oxadiazoles Chemical class 0.000 description 1
- 150000000182 1,3,5-triazines Chemical class 0.000 description 1
- KLCLIOISYBHYDZ-UHFFFAOYSA-N 1,4,4-triphenylbuta-1,3-dienylbenzene Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)=CC=C(C=1C=CC=CC=1)C1=CC=CC=C1 KLCLIOISYBHYDZ-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 125000004958 1,4-naphthylene group Chemical group 0.000 description 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 1
- ZMLPKJYZRQZLDA-UHFFFAOYSA-N 1-(2-phenylethenyl)-4-[4-(2-phenylethenyl)phenyl]benzene Chemical group C=1C=CC=CC=1C=CC(C=C1)=CC=C1C(C=C1)=CC=C1C=CC1=CC=CC=C1 ZMLPKJYZRQZLDA-UHFFFAOYSA-N 0.000 description 1
- ILBBNQMSDGAAPF-UHFFFAOYSA-N 1-(6-hydroxy-6-methylcyclohexa-2,4-dien-1-yl)propan-1-one Chemical compound CCC(=O)C1C=CC=CC1(C)O ILBBNQMSDGAAPF-UHFFFAOYSA-N 0.000 description 1
- VERMWGQSKPXSPZ-BUHFOSPRSA-N 1-[(e)-2-phenylethenyl]anthracene Chemical class C=1C=CC2=CC3=CC=CC=C3C=C2C=1\C=C\C1=CC=CC=C1 VERMWGQSKPXSPZ-BUHFOSPRSA-N 0.000 description 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 description 1
- PXELHGDYRQLRQO-UHFFFAOYSA-N 1-butyl-1-methylpyrrolidin-1-ium Chemical compound CCCC[N+]1(C)CCCC1 PXELHGDYRQLRQO-UHFFFAOYSA-N 0.000 description 1
- DDRGWXSVEYENPA-UHFFFAOYSA-M 1-butyl-2,3-dimethylimidazol-3-ium;octyl sulfate Chemical compound CCCC[N+]=1C=CN(C)C=1C.CCCCCCCCOS([O-])(=O)=O DDRGWXSVEYENPA-UHFFFAOYSA-M 0.000 description 1
- UVHXEHGUEKARKZ-UHFFFAOYSA-N 1-ethenylanthracene Chemical compound C1=CC=C2C=C3C(C=C)=CC=CC3=CC2=C1 UVHXEHGUEKARKZ-UHFFFAOYSA-N 0.000 description 1
- FQAXEPSLJLQFGZ-UHFFFAOYSA-N 1-ethyl-2,3,4-trimethylimidazol-1-ium Chemical compound CC[N+]=1C=C(C)N(C)C=1C FQAXEPSLJLQFGZ-UHFFFAOYSA-N 0.000 description 1
- COPVYYIIVFKLAY-UHFFFAOYSA-N 1-ethyl-3,4-dimethylimidazol-1-ium Chemical compound CC[N+]=1C=C(C)N(C)C=1 COPVYYIIVFKLAY-UHFFFAOYSA-N 0.000 description 1
- NJMWOUFKYKNWDW-UHFFFAOYSA-N 1-ethyl-3-methylimidazolium Chemical compound CCN1C=C[N+](C)=C1 NJMWOUFKYKNWDW-UHFFFAOYSA-N 0.000 description 1
- OGLIVJFAKNJZRE-UHFFFAOYSA-N 1-methyl-1-propylpiperidin-1-ium Chemical compound CCC[N+]1(C)CCCCC1 OGLIVJFAKNJZRE-UHFFFAOYSA-N 0.000 description 1
- YQFWGCSKGJMGHE-UHFFFAOYSA-N 1-methyl-1-propylpyrrolidin-1-ium Chemical compound CCC[N+]1(C)CCCC1 YQFWGCSKGJMGHE-UHFFFAOYSA-N 0.000 description 1
- MMJMYYUZGLJBST-UHFFFAOYSA-N 1-methyl-3-octadecylimidazol-1-ium Chemical compound CCCCCCCCCCCCCCCCCCN1C=C[N+](C)=C1 MMJMYYUZGLJBST-UHFFFAOYSA-N 0.000 description 1
- IDXFCXOPTUHTKE-UHFFFAOYSA-M 1-methyl-3-octylimidazol-1-ium;octyl sulfate Chemical compound CCCCCCCCOS([O-])(=O)=O.CCCCCCCC[N+]=1C=CN(C)C=1 IDXFCXOPTUHTKE-UHFFFAOYSA-M 0.000 description 1
- KMQPLEYEXDZOJF-UHFFFAOYSA-N 1-naphthalen-2-ylanthracene Chemical compound C1=CC=C2C=C3C(C4=CC5=CC=CC=C5C=C4)=CC=CC3=CC2=C1 KMQPLEYEXDZOJF-UHFFFAOYSA-N 0.000 description 1
- XNCMQRWVMWLODV-UHFFFAOYSA-N 1-phenylbenzimidazole Chemical compound C1=NC2=CC=CC=C2N1C1=CC=CC=C1 XNCMQRWVMWLODV-UHFFFAOYSA-N 0.000 description 1
- GUPMCMZMDAGSPF-UHFFFAOYSA-N 1-phenylbuta-1,3-dienylbenzene Chemical compound C=1C=CC=CC=1[C](C=C[CH2])C1=CC=CC=C1 GUPMCMZMDAGSPF-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- LAKFZOWEBGKEBB-UHFFFAOYSA-N 1H-imidazole indolo[3,2-c]carbazole Chemical class C1=CNC=N1.C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 LAKFZOWEBGKEBB-UHFFFAOYSA-N 0.000 description 1
- LPHIYKWSEYTCLW-UHFFFAOYSA-N 1h-azaborole Chemical class N1B=CC=C1 LPHIYKWSEYTCLW-UHFFFAOYSA-N 0.000 description 1
- PLJDGKPRGUMSAA-UHFFFAOYSA-N 2,2',7,7'-tetraphenyl-1,1'-spirobi[fluorene] Chemical compound C12=CC=C(C=3C=CC=CC=3)C=C2C=C(C23C(=CC=C4C5=CC=C(C=C5C=C43)C=3C=CC=CC=3)C=3C=CC=CC=3)C1=CC=C2C1=CC=CC=C1 PLJDGKPRGUMSAA-UHFFFAOYSA-N 0.000 description 1
- SULWTXOWAFVWOY-PHEQNACWSA-N 2,3-bis[(E)-2-phenylethenyl]pyrazine Chemical class C=1C=CC=CC=1/C=C/C1=NC=CN=C1\C=C\C1=CC=CC=C1 SULWTXOWAFVWOY-PHEQNACWSA-N 0.000 description 1
- MVWPVABZQQJTPL-UHFFFAOYSA-N 2,3-diphenylcyclohexa-2,5-diene-1,4-dione Chemical class O=C1C=CC(=O)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 MVWPVABZQQJTPL-UHFFFAOYSA-N 0.000 description 1
- BFTIPCRZWILUIY-UHFFFAOYSA-N 2,5,8,11-tetratert-butylperylene Chemical group CC(C)(C)C1=CC(C2=CC(C(C)(C)C)=CC=3C2=C2C=C(C=3)C(C)(C)C)=C3C2=CC(C(C)(C)C)=CC3=C1 BFTIPCRZWILUIY-UHFFFAOYSA-N 0.000 description 1
- UPZKDDJKJWYWHQ-UHFFFAOYSA-N 2-(3-azaniumyl-6-iminoxanthen-9-yl)benzoate Chemical compound C=12C=CC(=N)C=C2OC2=CC(N)=CC=C2C=1C1=CC=CC=C1C(O)=O UPZKDDJKJWYWHQ-UHFFFAOYSA-N 0.000 description 1
- CZBAIXSNXBGZRP-UHFFFAOYSA-N 2-(4-methylphenyl)-9,10-dinaphthalen-2-ylanthracene Chemical compound C1=CC(C)=CC=C1C1=CC=C(C(C=2C=C3C=CC=CC3=CC=2)=C2C(C=CC=C2)=C2C=3C=C4C=CC=CC4=CC=3)C2=C1 CZBAIXSNXBGZRP-UHFFFAOYSA-N 0.000 description 1
- PVFFUHAAOKXVTK-UHFFFAOYSA-N 2-(methylamino)-4-oxopentanoic acid Chemical compound CNC(C(O)=O)CC(C)=O PVFFUHAAOKXVTK-UHFFFAOYSA-N 0.000 description 1
- GEQBRULPNIVQPP-UHFFFAOYSA-N 2-[3,5-bis(1-phenylbenzimidazol-2-yl)phenyl]-1-phenylbenzimidazole Chemical compound C1=CC=CC=C1N1C2=CC=CC=C2N=C1C1=CC(C=2N(C3=CC=CC=C3N=2)C=2C=CC=CC=2)=CC(C=2N(C3=CC=CC=C3N=2)C=2C=CC=CC=2)=C1 GEQBRULPNIVQPP-UHFFFAOYSA-N 0.000 description 1
- ZTKQHJHANLVEBM-UHFFFAOYSA-N 2-[3-(ethylamino)-6-ethylimino-2,7-dimethylxanthen-9-yl]benzoic acid Chemical compound C1=2C=C(C)C(NCC)=CC=2OC2=CC(=NCC)C(C)=CC2=C1C1=CC=CC=C1C(O)=O ZTKQHJHANLVEBM-UHFFFAOYSA-N 0.000 description 1
- FBOKUMMWVKWLCK-UHFFFAOYSA-N 2-carbazol-9-yl-n,n-bis(4-carbazol-9-ylphenyl)aniline Chemical compound C12=CC=CC=C2C2=CC=CC=C2N1C1=CC=CC=C1N(C=1C=CC(=CC=1)N1C2=CC=CC=C2C2=CC=CC=C21)C1=CC=C(N2C3=CC=CC=C3C3=CC=CC=C32)C=C1 FBOKUMMWVKWLCK-UHFFFAOYSA-N 0.000 description 1
- VLRSADZEDXVUPG-UHFFFAOYSA-N 2-naphthalen-1-ylpyridine Chemical class N1=CC=CC=C1C1=CC=CC2=CC=CC=C12 VLRSADZEDXVUPG-UHFFFAOYSA-N 0.000 description 1
- 150000005360 2-phenylpyridines Chemical class 0.000 description 1
- FSEXLNMNADBYJU-UHFFFAOYSA-N 2-phenylquinoline Chemical class C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=N1 FSEXLNMNADBYJU-UHFFFAOYSA-N 0.000 description 1
- KYGSXEYUWRFVNY-UHFFFAOYSA-N 2-pyran-2-ylidenepropanedinitrile Chemical compound N#CC(C#N)=C1OC=CC=C1 KYGSXEYUWRFVNY-UHFFFAOYSA-N 0.000 description 1
- QLPKTAFPRRIFQX-UHFFFAOYSA-N 2-thiophen-2-ylpyridine Chemical class C1=CSC(C=2N=CC=CC=2)=C1 QLPKTAFPRRIFQX-UHFFFAOYSA-N 0.000 description 1
- ACNUVXZPCIABEX-UHFFFAOYSA-N 3',6'-diaminospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(N)C=C1OC1=CC(N)=CC=C21 ACNUVXZPCIABEX-UHFFFAOYSA-N 0.000 description 1
- DMEVMYSQZPJFOK-UHFFFAOYSA-N 3,4,5,6,9,10-hexazatetracyclo[12.4.0.02,7.08,13]octadeca-1(18),2(7),3,5,8(13),9,11,14,16-nonaene Chemical group N1=NN=C2C3=CC=CC=C3C3=CC=NN=C3C2=N1 DMEVMYSQZPJFOK-UHFFFAOYSA-N 0.000 description 1
- UZFPOOOQHWICKY-UHFFFAOYSA-N 3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(=C(C)C(C=C4N5)=N3)CCC(O)=O)=N2)C)=C(C)C(C(C)O)=C1C=C5C(C)=C4C(C)OC(C)C1=C(N2)C=C(N3)C(C)=C(C(O)C)C3=CC(C(C)=C3CCC(O)=O)=NC3=CC(C(CCC(O)=O)=C3C)=NC3=CC2=C1C UZFPOOOQHWICKY-UHFFFAOYSA-N 0.000 description 1
- XNBNKCLBGTWWSD-UHFFFAOYSA-N 3-[8,13,18-tris(2-carboxyethyl)-3,7,12,17-tetramethyl-21,24-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(C)C(=CC=3C(=C(CCC(O)=O)C(=C4)N=3)C)N2)CCC(O)=O)=C(CCC(O)=O)C(C)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 XNBNKCLBGTWWSD-UHFFFAOYSA-N 0.000 description 1
- UOVZEXYSWUAWQK-UHFFFAOYSA-N 3-ethyl-1,2,4-trimethylimidazol-1-ium Chemical compound CC[N+]=1C(C)=CN(C)C=1C UOVZEXYSWUAWQK-UHFFFAOYSA-N 0.000 description 1
- XDFUNRTWHPWCKO-UHFFFAOYSA-N 4,5,9,10-tetrahydropyrene Chemical class C1CC2=CC=CC3=C2C2=C1C=CC=C2CC3 XDFUNRTWHPWCKO-UHFFFAOYSA-N 0.000 description 1
- WPCIUCNVWJNRCD-UHFFFAOYSA-N 4,5-dihydropyrene Chemical class C1=CC=C2CCC3=CC=CC4=CC=C1C2=C34 WPCIUCNVWJNRCD-UHFFFAOYSA-N 0.000 description 1
- REHISTNPTFCXKS-UHFFFAOYSA-N 4-[2-[3-(iodomethyl)pyridin-2-yl]ethenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C=CC1=NC=CC=C1CI REHISTNPTFCXKS-UHFFFAOYSA-N 0.000 description 1
- OOHHGJZBRJBFRC-UHFFFAOYSA-N 4-[4-[4-(4-sulfophenyl)phenyl]phenyl]benzenesulfonic acid Chemical compound C1=CC(S(=O)(=O)O)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C=2C=CC(=CC=2)S(O)(=O)=O)C=C1 OOHHGJZBRJBFRC-UHFFFAOYSA-N 0.000 description 1
- AWXGSYPUMWKTBR-UHFFFAOYSA-N 4-carbazol-9-yl-n,n-bis(4-carbazol-9-ylphenyl)aniline Chemical compound C12=CC=CC=C2C2=CC=CC=C2N1C1=CC=C(N(C=2C=CC(=CC=2)N2C3=CC=CC=C3C3=CC=CC=C32)C=2C=CC(=CC=2)N2C3=CC=CC=C3C3=CC=CC=C32)C=C1 AWXGSYPUMWKTBR-UHFFFAOYSA-N 0.000 description 1
- LQYYDWJDEVKDGB-XPWSMXQVSA-N 4-methyl-n-[4-[(e)-2-[4-[(e)-2-[4-(4-methyl-n-(4-methylphenyl)anilino)phenyl]ethenyl]phenyl]ethenyl]phenyl]-n-(4-methylphenyl)aniline Chemical compound C1=CC(C)=CC=C1N(C=1C=CC(\C=C\C=2C=CC(\C=C\C=3C=CC(=CC=3)N(C=3C=CC(C)=CC=3)C=3C=CC(C)=CC=3)=CC=2)=CC=1)C1=CC=C(C)C=C1 LQYYDWJDEVKDGB-XPWSMXQVSA-N 0.000 description 1
- HPMDJLFQPKZBGR-UHFFFAOYSA-N 4-methyl-n-[4-[1-[4-(4-methyl-n-(4-methylphenyl)anilino)phenyl]-3-phenylpropyl]phenyl]-n-(4-methylphenyl)aniline Chemical compound C1=CC(C)=CC=C1N(C=1C=CC(=CC=1)C(CCC=1C=CC=CC=1)C=1C=CC(=CC=1)N(C=1C=CC(C)=CC=1)C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 HPMDJLFQPKZBGR-UHFFFAOYSA-N 0.000 description 1
- MVIXNQZIMMIGEL-UHFFFAOYSA-N 4-methyl-n-[4-[4-(4-methyl-n-(4-methylphenyl)anilino)phenyl]phenyl]-n-(4-methylphenyl)aniline Chemical group C1=CC(C)=CC=C1N(C=1C=CC(=CC=1)C=1C=CC(=CC=1)N(C=1C=CC(C)=CC=1)C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 MVIXNQZIMMIGEL-UHFFFAOYSA-N 0.000 description 1
- XDTYUYVIGLIFCW-UHFFFAOYSA-N 4-phenylbenzenesulfonic acid Chemical compound C1=CC(S(=O)(=O)O)=CC=C1C1=CC=CC=C1 XDTYUYVIGLIFCW-UHFFFAOYSA-N 0.000 description 1
- UUSGRTCQLNWCHP-UHFFFAOYSA-N 4-tert-butyl-2-(3-phenylphenyl)pyridine Chemical compound CC(C)(C)C1=CC=NC(C=2C=C(C=CC=2)C=2C=CC=CC=2)=C1 UUSGRTCQLNWCHP-UHFFFAOYSA-N 0.000 description 1
- SCZWJXTUYYSKGF-UHFFFAOYSA-N 5,12-dimethylquinolino[2,3-b]acridine-7,14-dione Chemical compound CN1C2=CC=CC=C2C(=O)C2=C1C=C1C(=O)C3=CC=CC=C3N(C)C1=C2 SCZWJXTUYYSKGF-UHFFFAOYSA-N 0.000 description 1
- IPEMCIBPDYCJLO-UHFFFAOYSA-N 5-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]-n-(2,4,6-trimethoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC(OC)=CC(OC)=C1NC(=O)C(O1)=CC=C1CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C IPEMCIBPDYCJLO-UHFFFAOYSA-N 0.000 description 1
- 229950010481 5-aminolevulinic acid hydrochloride Drugs 0.000 description 1
- MZCJSUCRGWIKHH-UHFFFAOYSA-N 6,7-dihydrobenzo[d][1]benzoxepine Chemical class O1CCC2=CC=CC=C2C2=CC=CC=C21 MZCJSUCRGWIKHH-UHFFFAOYSA-N 0.000 description 1
- BITWULPDIGXQDL-UHFFFAOYSA-N 9,10-bis[4-(2,2-diphenylethenyl)phenyl]anthracene Chemical compound C=1C=C(C=2C3=CC=CC=C3C(C=3C=CC(C=C(C=4C=CC=CC=4)C=4C=CC=CC=4)=CC=3)=C3C=CC=CC3=2)C=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 BITWULPDIGXQDL-UHFFFAOYSA-N 0.000 description 1
- XXPBFNVKTVJZKF-UHFFFAOYSA-N 9,10-dihydrophenanthrene Chemical class C1=CC=C2CCC3=CC=CC=C3C2=C1 XXPBFNVKTVJZKF-UHFFFAOYSA-N 0.000 description 1
- FCNCGHJSNVOIKE-UHFFFAOYSA-N 9,10-diphenylanthracene Chemical class C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=CC=C2)C2=C1C1=CC=CC=C1 FCNCGHJSNVOIKE-UHFFFAOYSA-N 0.000 description 1
- SNFCXVRWFNAHQX-UHFFFAOYSA-N 9,9'-spirobi[fluorene] Chemical class C12=CC=CC=C2C2=CC=CC=C2C21C1=CC=CC=C1C1=CC=CC=C21 SNFCXVRWFNAHQX-UHFFFAOYSA-N 0.000 description 1
- CVXXPNSMZIRFAA-UHFFFAOYSA-N 9-(3-carbazol-9-yl-5-phenylphenyl)carbazole Chemical group C1=CC=CC=C1C1=CC(N2C3=CC=CC=C3C3=CC=CC=C32)=CC(N2C3=CC=CC=C3C3=CC=CC=C32)=C1 CVXXPNSMZIRFAA-UHFFFAOYSA-N 0.000 description 1
- ZYASLTYCYTYKFC-UHFFFAOYSA-N 9-methylidenefluorene Chemical class C1=CC=C2C(=C)C3=CC=CC=C3C2=C1 ZYASLTYCYTYKFC-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- VESMRDNBVZOIEN-UHFFFAOYSA-N 9h-carbazole-1,2-diamine Chemical compound C1=CC=C2C3=CC=C(N)C(N)=C3NC2=C1 VESMRDNBVZOIEN-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 206010000501 Acne conglobata Diseases 0.000 description 1
- 206010000502 Acne cosmetica Diseases 0.000 description 1
- 206010049141 Acne fulminans Diseases 0.000 description 1
- 206010000518 Acne varioliformis Diseases 0.000 description 1
- 208000007815 Acquired Hyperostosis Syndrome Diseases 0.000 description 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 1
- 206010001766 Alopecia totalis Diseases 0.000 description 1
- 206010001767 Alopecia universalis Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 208000028185 Angioedema Diseases 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000203069 Archaea Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- HKMTVMBEALTRRR-UHFFFAOYSA-N Benzo[a]fluorene Chemical compound C1=CC=CC2=C3CC4=CC=CC=C4C3=CC=C21 HKMTVMBEALTRRR-UHFFFAOYSA-N 0.000 description 1
- 206010056375 Bile duct obstruction Diseases 0.000 description 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
- 208000021130 Bilirubin encephalopathy Diseases 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 206010006550 Bulimia nervosa Diseases 0.000 description 1
- 206010006811 Bursitis Diseases 0.000 description 1
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical class C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
- FIZZUEJIOKEFFZ-UHFFFAOYSA-M C3-oxacyanine Chemical compound [I-].O1C2=CC=CC=C2[N+](CC)=C1C=CC=C1N(CC)C2=CC=CC=C2O1 FIZZUEJIOKEFFZ-UHFFFAOYSA-M 0.000 description 1
- VSEIDZLLWQQJGK-CHOZPQDDSA-N CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O Chemical compound CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O VSEIDZLLWQQJGK-CHOZPQDDSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010072578 Chronic actinic dermatitis Diseases 0.000 description 1
- 241000202285 Claravis Species 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 208000000907 Condylomata Acuminata Diseases 0.000 description 1
- 206010010317 Congenital absence of bile ducts Diseases 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 208000001819 Crigler-Najjar Syndrome Diseases 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 206010065701 Dermatillomania Diseases 0.000 description 1
- 206010012432 Dermatitis acneiform Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010051392 Diapedesis Diseases 0.000 description 1
- 201000003066 Diffuse Scleroderma Diseases 0.000 description 1
- 208000019872 Drug Eruptions Diseases 0.000 description 1
- 208000006402 Ductal Carcinoma Diseases 0.000 description 1
- 102000015689 E-Selectin Human genes 0.000 description 1
- 108010024212 E-Selectin Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241001635598 Enicostema Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 229910016855 F9SO2 Inorganic materials 0.000 description 1
- 229910016861 F9SO3 Inorganic materials 0.000 description 1
- 241000242711 Fasciola hepatica Species 0.000 description 1
- 208000000901 Focal Epithelial Hyperplasia Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000025499 G6PD deficiency Diseases 0.000 description 1
- 208000009139 Gilbert Disease Diseases 0.000 description 1
- 208000022412 Gilbert syndrome Diseases 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 206010018444 Glucose-6-phosphate dehydrogenase deficiency Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 206010019771 Hepatitis F Diseases 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 101000837344 Homo sapiens T-cell leukemia translocation-altered gene protein Proteins 0.000 description 1
- 241000701041 Human betaherpesvirus 7 Species 0.000 description 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 241001662043 Icterus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010023330 Keloid scar Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 206010066295 Keratosis pilaris Diseases 0.000 description 1
- 206010024238 Leptospirosis Diseases 0.000 description 1
- 206010024380 Leukoderma Diseases 0.000 description 1
- 208000005995 Lichenoid Eruptions Diseases 0.000 description 1
- YHBTXTFFTYXOFV-UHFFFAOYSA-N Liquid thiophthene Chemical compound C1=CSC2=C1C=CS2 YHBTXTFFTYXOFV-UHFFFAOYSA-N 0.000 description 1
- 206010056301 Lupus miliaris disseminatus faciei Diseases 0.000 description 1
- 206010025282 Lymphoedema Diseases 0.000 description 1
- 206010068773 Mechanical urticaria Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 208000000996 Mirizzi syndrome Diseases 0.000 description 1
- 206010027940 Mood altered Diseases 0.000 description 1
- 208000014879 Morbihan disease Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 229910017673 NH4PF6 Inorganic materials 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000006098 Neonatal Hyperbilirubinemia Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 208000014060 Niemann-Pick disease Diseases 0.000 description 1
- 206010072139 Ocular rosacea Diseases 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 229920000144 PEDOT:PSS Polymers 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010033635 Pancreatic pseudocyst Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 description 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 201000011152 Pemphigus Diseases 0.000 description 1
- 208000000766 Pityriasis Lichenoides Diseases 0.000 description 1
- 208000010332 Plantar Fasciitis Diseases 0.000 description 1
- 229920000265 Polyparaphenylene Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000006311 Pyoderma Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 208000003493 Rhinophyma Diseases 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 201000004854 SAPHO syndrome Diseases 0.000 description 1
- 229910006069 SO3H Inorganic materials 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 102000003800 Selectins Human genes 0.000 description 1
- 108090000184 Selectins Proteins 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- 229910000577 Silicon-germanium Inorganic materials 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 206010041509 Spherocytic anaemia Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000006069 Suzuki reaction reaction Methods 0.000 description 1
- 201000009594 Systemic Scleroderma Diseases 0.000 description 1
- 206010042953 Systemic sclerosis Diseases 0.000 description 1
- 102100028692 T-cell leukemia translocation-altered gene protein Human genes 0.000 description 1
- 206010042971 T-cell lymphoma Diseases 0.000 description 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 229910003087 TiOx Inorganic materials 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010046752 Urticaria Pigmentosa Diseases 0.000 description 1
- 208000012544 Viral Skin disease Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229910003134 ZrOx Inorganic materials 0.000 description 1
- NCKJIJSEWKIXAT-QURGRASLSA-N [(e)-2-diphenylphosphanylethenyl]-diphenylphosphane Chemical group C=1C=CC=CC=1P(C=1C=CC=CC=1)/C=C/P(C=1C=CC=CC=1)C1=CC=CC=C1 NCKJIJSEWKIXAT-QURGRASLSA-N 0.000 description 1
- 239000005092 [Ru (Bpy)3]2+ Substances 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 150000001251 acridines Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 229960002916 adapalene Drugs 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000011256 aggressive treatment Methods 0.000 description 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 208000032775 alopecia universalis congenita Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- IUFDZNVMARBLOJ-UHFFFAOYSA-K aluminum;quinoline-2-carboxylate Chemical compound [Al+3].C1=CC=CC2=NC(C(=O)[O-])=CC=C21.C1=CC=CC2=NC(C(=O)[O-])=CC=C21.C1=CC=CC2=NC(C(=O)[O-])=CC=C21 IUFDZNVMARBLOJ-UHFFFAOYSA-K 0.000 description 1
- 229940022824 amnesteem Drugs 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
- 201000004201 anogenital venereal wart Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- YUENFNPLGJCNRB-UHFFFAOYSA-N anthracen-1-amine Chemical compound C1=CC=C2C=C3C(N)=CC=CC3=CC2=C1 YUENFNPLGJCNRB-UHFFFAOYSA-N 0.000 description 1
- VVLCNWYWKSWJTG-UHFFFAOYSA-N anthracene-1,2-diamine Chemical compound C1=CC=CC2=CC3=C(N)C(N)=CC=C3C=C21 VVLCNWYWKSWJTG-UHFFFAOYSA-N 0.000 description 1
- 150000008425 anthrones Chemical class 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000000040 apocrine gland Anatomy 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000005110 aryl thio group Chemical group 0.000 description 1
- 125000000732 arylene group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 1
- WZJYKHNJTSNBHV-UHFFFAOYSA-N benzo[h]quinoline Chemical class C1=CN=C2C3=CC=CC=C3C=CC2=C1 WZJYKHNJTSNBHV-UHFFFAOYSA-N 0.000 description 1
- 229960002045 bergapten Drugs 0.000 description 1
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 201000005271 biliary atresia Diseases 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 125000006268 biphenyl-3-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(*)=C([H])C([H])=C1[H] 0.000 description 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- JRXXLCKWQFKACW-UHFFFAOYSA-N biphenylacetylene Chemical compound C1=CC=CC=C1C#CC1=CC=CC=C1 JRXXLCKWQFKACW-UHFFFAOYSA-N 0.000 description 1
- DMEDSJKEUMLSKF-UHFFFAOYSA-N bis(trifluoromethylsulfonyl)azanide;1-methyl-3-octadecylimidazol-1-ium Chemical compound FC(F)(F)S(=O)(=O)[N-]S(=O)(=O)C(F)(F)F.CCCCCCCCCCCCCCCCCC[N+]=1C=CN(C)C=1 DMEDSJKEUMLSKF-UHFFFAOYSA-N 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- UORVGPXVDQYIDP-BJUDXGSMSA-N borane Chemical class [10BH3] UORVGPXVDQYIDP-BJUDXGSMSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 206010006060 bowenoid papulosis Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000013547 bright light therapy Methods 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- VJBODIYZSOOKES-UHFFFAOYSA-N butyl-ethyl-dimethylazanium Chemical compound CCCC[N+](C)(C)CC VJBODIYZSOOKES-UHFFFAOYSA-N 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000005606 carbostyryl group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 150000001767 cationic compounds Chemical class 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000002800 charge carrier Substances 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- VYXSBFYARXAAKO-WTKGSRSZSA-N chembl402140 Chemical compound Cl.C1=2C=C(C)C(NCC)=CC=2OC2=C\C(=N/CC)C(C)=CC2=C1C1=CC=CC=C1C(=O)OCC VYXSBFYARXAAKO-WTKGSRSZSA-N 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- OQENBJBTQPIZKA-UHFFFAOYSA-N chrysen-1-amine Chemical class C1=CC2=C3C=CC=CC3=CC=C2C2=C1C(N)=CC=C2 OQENBJBTQPIZKA-UHFFFAOYSA-N 0.000 description 1
- ILSGDBURWYKYHE-UHFFFAOYSA-N chrysene-1,2-diamine Chemical class C1=CC=CC2=CC=C3C4=CC=C(N)C(N)=C4C=CC3=C21 ILSGDBURWYKYHE-UHFFFAOYSA-N 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 229940031301 claravis Drugs 0.000 description 1
- 229940060799 clarus Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 238000009225 cognitive behavioral therapy Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical class C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000000409 dermatographia Diseases 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical class N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 description 1
- TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 description 1
- 229940002658 differin Drugs 0.000 description 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical class [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- PDLMANZZQGWAIR-UHFFFAOYSA-L disodium;4-[4-[4-(4-sulfonatophenyl)phenyl]phenyl]benzenesulfonate Chemical compound [Na+].[Na+].C1=CC(S(=O)(=O)[O-])=CC=C1C1=CC=C(C=2C=CC(=CC=2)C=2C=CC(=CC=2)S([O-])(=O)=O)C=C1 PDLMANZZQGWAIR-UHFFFAOYSA-L 0.000 description 1
- 208000018211 dissecting cellulitis of the scalp Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- HKNRNTYTYUWGLN-UHFFFAOYSA-N dithieno[3,2-a:2',3'-d]thiophene Chemical compound C1=CSC2=C1SC1=C2C=CS1 HKNRNTYTYUWGLN-UHFFFAOYSA-N 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 description 1
- 229960004845 drospirenone Drugs 0.000 description 1
- 229960000925 efaproxiral Drugs 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- 238000005401 electroluminescence Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 201000004306 epidermodysplasia verruciformis Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- ZOZZQPFBMNNPPO-UHFFFAOYSA-N ethyl-dimethyl-propylazanium Chemical compound CCC[N+](C)(C)CC ZOZZQPFBMNNPPO-UHFFFAOYSA-N 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 208000020157 familial dermatographia Diseases 0.000 description 1
- 208000006275 fascioliasis Diseases 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical class O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 208000008605 glucosephosphate dehydrogenase deficiency Diseases 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 229910021472 group 8 element Inorganic materials 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- CJNBYAVZURUTKZ-UHFFFAOYSA-N hafnium(IV) oxide Inorganic materials O=[Hf]=O CJNBYAVZURUTKZ-UHFFFAOYSA-N 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960003569 hematoporphyrin Drugs 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 208000002557 hidradenitis Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 229940083761 high-ceiling diuretics pyrazolone derivative Drugs 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001329 hyperkeratotic effect Effects 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 208000012116 immunodeficiency-related disease Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- SWGQKRKXZZPKJA-UHFFFAOYSA-N indeno[2,1-a]fluorene-1,2-diamine Chemical class C1=CC=C2C=C3C4=CC5=C(N)C(N)=CC=C5C4=CC=C3C2=C1 SWGQKRKXZZPKJA-UHFFFAOYSA-N 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 229910001411 inorganic cation Inorganic materials 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 210000001613 integumentary system Anatomy 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 208000006663 kernicterus Diseases 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 239000000990 laser dye Substances 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- AHEVKYYGXVEWNO-UEPZRUIBSA-N lymecycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(=O)NCNCCCC[C@H](N)C(O)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O AHEVKYYGXVEWNO-UEPZRUIBSA-N 0.000 description 1
- 229960004196 lymecycline Drugs 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 208000002502 lymphedema Diseases 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 208000030179 maculopapular cutaneous mastocytosis Diseases 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- 239000005267 main chain polymer Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 208000011645 metastatic carcinoma Diseases 0.000 description 1
- 238000005649 metathesis reaction Methods 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- YUUAYBAIHCDHHD-UHFFFAOYSA-N methyl 5-aminolevulinate Chemical compound COC(=O)CCC(=O)CN YUUAYBAIHCDHHD-UHFFFAOYSA-N 0.000 description 1
- 229960005033 methyl aminolevulinate Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000007510 mood change Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 201000010241 mucinoses Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- IBHBKWKFFTZAHE-UHFFFAOYSA-N n-[4-[4-(n-naphthalen-1-ylanilino)phenyl]phenyl]-n-phenylnaphthalen-1-amine Chemical group C1=CC=CC=C1N(C=1C2=CC=CC=C2C=CC=1)C1=CC=C(C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C3=CC=CC=C3C=CC=2)C=C1 IBHBKWKFFTZAHE-UHFFFAOYSA-N 0.000 description 1
- RYZPDEZIQWOVPJ-UHFFFAOYSA-N n-naphthalen-1-yl-n-[4-[4-[naphthalen-1-yl(naphthalen-2-yl)amino]phenyl]phenyl]naphthalen-2-amine Chemical group C1=CC=C2C(N(C=3C=CC(=CC=3)C=3C=CC(=CC=3)N(C=3C=C4C=CC=CC4=CC=3)C=3C4=CC=CC=C4C=CC=3)C3=CC4=CC=CC=C4C=C3)=CC=CC2=C1 RYZPDEZIQWOVPJ-UHFFFAOYSA-N 0.000 description 1
- 125000006608 n-octyloxy group Chemical group 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003448 neutrophilic effect Effects 0.000 description 1
- 229940078552 o-xylene Drugs 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 150000002892 organic cations Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 150000004866 oxadiazoles Chemical class 0.000 description 1
- 150000007978 oxazole derivatives Chemical class 0.000 description 1
- 150000002916 oxazoles Chemical class 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- RJCRUVXAWQRZKQ-UHFFFAOYSA-N oxosilicon;silicon Chemical compound [Si].[Si]=O RJCRUVXAWQRZKQ-UHFFFAOYSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 206010033898 parapsoriasis Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 201000001976 pemphigus vulgaris Diseases 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000002979 perylenes Chemical class 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 150000003003 phosphines Chemical class 0.000 description 1
- 150000003004 phosphinoxides Chemical class 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 230000002215 photochemotherapeutic effect Effects 0.000 description 1
- 238000000103 photoluminescence spectrum Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920002098 polyfluorene Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000128 polypyrrole Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229960002796 polystyrene sulfonate Drugs 0.000 description 1
- 239000011970 polystyrene sulfonate Substances 0.000 description 1
- 229960004293 porfimer sodium Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical group CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000001823 pruritic effect Effects 0.000 description 1
- 238000004549 pulsed laser deposition Methods 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- 150000003219 pyrazolines Chemical class 0.000 description 1
- BUAWIRPPAOOHKD-UHFFFAOYSA-N pyrene-1,2-diamine Chemical class C1=CC=C2C=CC3=C(N)C(N)=CC4=CC=C1C2=C43 BUAWIRPPAOOHKD-UHFFFAOYSA-N 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- 150000004892 pyridazines Chemical class 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- WVIICGIFSIBFOG-UHFFFAOYSA-N pyrylium Chemical compound C1=CC=[O+]C=C1 WVIICGIFSIBFOG-UHFFFAOYSA-N 0.000 description 1
- 230000005610 quantum mechanics Effects 0.000 description 1
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 150000003252 quinoxalines Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229940002683 retin-a Drugs 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 150000003967 siloles Chemical class 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 206010041307 solar urticaria Diseases 0.000 description 1
- 229940034345 sotret Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 229920006301 statistical copolymer Polymers 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 150000001629 stilbenes Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 229950010924 talaporfin Drugs 0.000 description 1
- 229960000565 tazarotene Drugs 0.000 description 1
- 229940036234 tazorac Drugs 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003513 tertiary aromatic amines Chemical class 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- NMFKEMBATXKZSP-UHFFFAOYSA-N thieno[3,2-b]thiophene Chemical compound S1C=CC2=C1C=CS2.S1C=CC2=C1C=CS2 NMFKEMBATXKZSP-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000004882 thiopyrans Chemical class 0.000 description 1
- HLLICFJUWSZHRJ-UHFFFAOYSA-N tioxidazole Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)SC2=C1 HLLICFJUWSZHRJ-UHFFFAOYSA-N 0.000 description 1
- 230000019432 tissue death Effects 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- JFZKOODUSFUFIZ-UHFFFAOYSA-N trifluoro phosphate Chemical compound FOP(=O)(OF)OF JFZKOODUSFUFIZ-UHFFFAOYSA-N 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- PYVOHVLEZJMINC-UHFFFAOYSA-N trihexyl(tetradecyl)phosphanium Chemical compound CCCCCCCCCCCCCC[P+](CCCCCC)(CCCCCC)CCCCCC PYVOHVLEZJMINC-UHFFFAOYSA-N 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
- 229960003895 verteporfin Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 150000003732 xanthenes Chemical class 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B33/00—Electroluminescent light sources
- H05B33/12—Light sources with substantially two-dimensional radiating surfaces
- H05B33/14—Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the electroluminescent material, or by the simultaneous addition of the electroluminescent material in or onto the light source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0653—Organic light emitting diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0656—Chemical light sources
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/14—Macromolecular compounds
- C09K2211/1408—Carbocyclic compounds
- C09K2211/1416—Condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/14—Macromolecular compounds
- C09K2211/1408—Carbocyclic compounds
- C09K2211/1425—Non-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/14—Macromolecular compounds
- C09K2211/1408—Carbocyclic compounds
- C09K2211/1433—Carbocyclic compounds bridged by heteroatoms, e.g. N, P, Si or B
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/14—Macromolecular compounds
- C09K2211/1441—Heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/18—Metal complexes
- C09K2211/185—Metal complexes of the platinum group, i.e. Os, Ir, Pt, Ru, Rh or Pd
Definitions
- the present invention relates inter alia to compositions comprising at least . one electroluminescent compound which can be used for the treatment and/or prophylaxis of therapeutic diseases and/or cosmetic conditions.
- the present invention also relates to devices comprising said compositions and their applications in therapeutic and cosmetic applications.
- Phototherapy also called light therapy
- the therapy using light is already being used to treat wounds, injuries, neck pain, osteoarthritis, the side effects of chemotherapy and radiotherapy, for instance.
- the borders between therapeutic and cosmetic applications are vague and depend on individual circumstances and the assessment of a physician.
- therapeutic conditions are associated with cosmetic consideration.
- the treatment or prophylaxis of acne may have both therapeutic and cosmetic components, depending on the degree of the condition.
- the same accounts for psoriasis, atopic dermatitis and other diseases and/or conditions.
- Many diseases and conditions are associated with apparent implications which are often represented by a change in the visibility of a subject's skin, for instance. These cosmetic or aesthetic changes can lead to psychological modifications resulting, at least in part, in serious diseases.
- Some conditions or diseases may have an emphasis on cosmetic components, even if therapeutic elements may also play a role. Some of these are selected from anti-ageing, anti-wrinkle, the prevention and/or therapy of acne and vitiligo.
- Many diagnostic tools or devices may also require light sources, e.g., in order to determine blood characteristics such as bilirubin, oxygen, or CO.
- the skin is the main target to be radiated, but other targets of the human or animal body can also be accessed by phototherapy. These targets include, but are not limited to, the eye, wounds, nails, and internal parts of the body.
- Light can also be used in order to facilitate or support sterilization and/or disinfection of wounds, beverages, nutrition, for example.
- One of the primary effects of phototherapy is the stimulation of metabolism in the mitochondria. Certain wavelengths of light stimulate cytochrome c oxidase, an enzyme which is responsible for the production of the essential cellular energy in the form of adenosine triphosphate (ATP).
- cytochrome c oxidase an enzyme which is responsible for the production of the essential cellular energy in the form of adenosine triphosphate (ATP).
- ATP is required for cellular energy transfer in order to drive thermo- dynamically unfavoured biochemical reactions and as cellular energy storage. ATP can also act as signal molecule in order to modulate other biochemical molecules (e.g. reactive oxygen species and nitric oxide) that lead to ageing and cell death (oxidative stress). After phototherapy, the cells show an increased metabolism, they communicate better and they survive stressful conditions in a better way.
- biochemical molecules e.g. reactive oxygen species and nitric oxide
- Such principle can be applied for medicinal therapeutic and cosmetic applications, such as wound healing, connective tissue repair, tissue repair, prevention of tissue death, relief of inflammation, pain, acute injuries, chronic diseases, metabolic disorders, neurogenic pain and seasonal effect disorders.
- PDT photodynamic therapy
- a light-sensitive therapeutic agent known as a photo- pharmaceutical is supplied externally or internally to an area of the body which is to be treated. That area is then exposed to light of a suitable frequency and intensity to activate the photopharmaceutical.
- photopharmaceutical agents are currently available. For example there are topical agents such as 5-aminolevulinic acid hydrochloride (Crawford Pharmaceuticals), methylaminolevulinic acid (Metfix®, Photocure).
- injectable drugs used primarily for internal malignancies, including Photofin® (from Axcan) and Foscan® (from Biolitech Ltd). Often, the drug is applied in a non-active form that is metabolised to a light-sensitive photopharmaceutical.
- the primary technique for supplying light to the photopharmaceutical is to project light of a suitable wavelength from standalone light sources such as lasers or filtered arc lamps. These sources are cumbersome and expensive, and are therefore only suitable for use in hospitals. This leads to inconvenience for the patient, and high cost for the treatment. High light irradiances are needed in order to treat an acceptable number of patients per day (for the treatment to be cost effective) and to avoid unduly inconveniencing the patient.
- WO 98/46130 and US 6096066 disclose arrays of LEDs for use in photo- dynamic therapy.
- the small LED sources taught therein result in uneven light incident on the patient. Fabrication of arrays is complicated, because of the large number of connections required.
- the devices shown therein are designed for hospital treatment.
- GB 2360461 discloses a flexible garment which uses a conventional photodynamic therapy light source to produce light which is then transmitted through optical fibres. As such light sources are heavy, the device is not ambulatory and is limited to hospital use.
- US 5698866 discloses a light source using over-driven inorganic LEDs. The resulting light output is not even. A heat-sinking mechanism is required, and the device is suitable only for hospital treatment.
- WO 93/21842 disclose light sources using inorganic LEDs. Although transportable, the device is not suitable for ambulatory use by a patient at home and clinical treatment is envisaged.
- a further problem with existing approaches is that it can be difficult to achieve uniform illumination with such sources, especially on curved body parts.
- An essential prerequisite for the application of light in the fields mentioned above is the device.
- the commercial available systems nowadays are mostly based on lasers.
- theses systems are hospital based, i.e. stationary devices.
- a portable home-use technology is required.
- some research has been devoted in this direction.
- a flexible medical light source comprising flexible light emitting diodes form on flexible substrate and resulting diagnostic devices directed to monitoring blood characteristics (e.g. levels of CO, oxygen, or bilirubin) and photo-therapeutic devices for treatment of ailments.
- blood characteristics e.g. levels of CO, oxygen, or bilirubin
- Vogle Klaus and Kallert Heiko disclosed in EP 018180773 a device for the treatment of skin.
- the device comprises an potentially flexible organic light emitting diode (OLED) as light source.
- OLED organic light emitting diode
- the device can be integrated in clothes or plaster.
- EP 1444008B15 an ambulatory device for the use in a therapeutic and/or cosmetic treatment, the device comprises an OLEDs and poly(p-phenylene vinylene) (PPV) used as an example.
- EP 1444008 discloses the Devices for the treatment of photodynamic therapy comprising OLEDs.
- Organic light emitting diodes have many advantages over their inorganic counterpart (light emitting diodes - LEDs) in that they are intrinsically flexible, and can be coated on large area by, for example, printing technologies, such as ink jet printing and screen printing.
- printing technologies such as ink jet printing and screen printing.
- active metals such as Ba and Ca
- cathode active metals, such as Ba and Ca
- Oxygen and humidity can inhibit or destroy the function of OLEDs. There is, therefore, a need for the development of novel thin light sources without the drawbacks as described above.
- organic light emitting electrochemical cells can be used as light sources for the treatment and prophylaxis of medical and/or cosmetic diseases and conditions.
- OLECs are very simple in their structure and therefore easily prepared.
- the preparation of devices with curved or three dimensional surfaces is in the case of OLECs less complex as compared to the preparation of such surfaces in OLEDs. This is due to the fact that the requirements relating to homogeneity of the layer is less stringent.
- the production costs in particular for mass production are much lower as compared to the ones of OLEDs.
- OLECs do not rely on air-sensitive charge-injection layers or metals such as Ba or Cs for electron injection, which further simplifies their preparation and makes them more cost efficient, as compared to
- OLEDs and LEDs are diodes with forward bias and reverse bias.
- l-V (current-voltage) curves of both OLEDs and LEDs are asymmetric. They represent semiconductor technologies whereas an OLEC is basically an electrochemical or more precisely an electrolytic cell.
- Charge transport in OLEDs occurs via the movement of holes and electrons from molecule to molecule until holes and electrons form so called excitons, i.e. electron-hole-pairs. Light is emitted when electrons and holes recombine.
- the electrolyte upon applying a voltage, the electrolyte is oxidized at the anode and reduced at the cathode.
- Another possible type of light emitting device comprising ionic materials is a device with an ionic p-n junction as reported by Daniel A. Bernards, et al., Science 2008, 313, 1416, wherein two layers are laminated together. One of the layers has a mobile anion and the other one has a mobile cation; by ion exchange an ionic p-n junction is formed in the interface between two layers. Here the ionic p-n junction is formed before the voltage is applied. The emission of light can then occur in the p-n junction.
- a similar light emitting device was also disclosed in US 2007/0157662 A1.
- the present invention relates to a composition for the treatment and/or prophylaxis of therapeutic diseases and/or cosmetic conditions,
- the composition comprises at least one ionic species and at least one organic electroluminescent compound.
- the ionic species can be an organic or inorganic ion.
- the ionic species is a mobile ion.
- the composition comprises 3, particularly preferably 2, and very particularly preferably 1 organic electroluminescent compound.
- the composition comprises 3, particularly preferably 2, and very particularly preferably 1 ionic species.
- the said composition is transferred into its therapeutically and/or cosmetically active state by applying a voltage to the compositions.
- the composition preferably emits light with a specific wavelength or light with a range of wavelengths when a voltage is applied .
- any therapeutic strategy is included, ie. treatment of a subject with light can be performed with or without a combination with other treatment approaches. Treatment can, for example, carried out with one or more wavelengths in one or more devices comprising the composition of the present invention.
- further light sources using different technologies can be used for the treatment, such as LEDs, OLEDs, and lasers.
- the treatment with said compositions and devices comprising them can be combined with any known treatment strategy using drugs and cosmetics.
- phototherapy is combined with the treatment of chemical compounds such as a drugs and/or cosmetics light can be used to initiate a (photo-) chemical reaction or activation of the chemical compounds, which is called photodynamic therapy (PDT).
- Phototherapy according to the present invention can also be used in conjunction with chemical com- pounds without initiating a photochemical reaction or activation.
- Synergistic effects for the effectiveness and safety of the treatment of a therapeutic disease can arise from sequential, parallel, and overlapping treatment with both light therapy and drugs and/or cosmetics.
- the drug(s) or cosmetic compound(s) e.g., can be administered first for a specific time period followed by the application of phototherapy using the compositions according to the present invention or devices comprising them.
- the time gap between both treatments may also vary, depending on the drug, its photoreactivity, individual circumstances of the subject, and the specific disease or condition. Both treatments may also overlap timely either partly or completely. The exact treatment strategy will depend on the individual circumstances and the severity of the disease or condition.
- the combination therapy can have a synergistic effect and can reduce the side effects of traditional treatment strategies (e.g. the side effects of tetracyclines). This is due to the fact, that smaller doses of the drugs may be required when following the combined approach as outlined herein.
- Many diagnostic devices comprise light sources for either illumination only or as functional component for the diagnosis itself, e.g. for the
- the present invention also relates to a composition for diagnostic purposes,
- composition comprises at least one ionic species and at least one organic electroluminescent compound.
- light sources comprising the said compositions for diagnostic purposes is also subject of the present invention. Based on the teaching of the present invention, one skilled in the art will have no problems to develop
- Treatment is any exposure of a subject to the radiation of the composition.
- the treatment may be performed by direct contact between the subject and the device comprising the composition or without direct contact between them.
- the treatment may be outside or inside the subject.
- Treatment outside the subject may be, for instance, treatment of the skin, wounds, eye, gingival, mucosa, tongue, hair, nail bed, and nails.
- Treatment inside the subject may be, for instance, blood vessels, heart, breast, lung, or any other organ of the subject. Particular devices are required for most applications inside the subject.
- One such example may be a stent comprising a composition according to the present invention.
- the said subject may preferably be a human or an animal.
- the term cosmetic also includes aesthetic applications. The wavelength of light that is emitted by the composition when
- the composition preferably comprises at least one organic electroluminescent compound which emit light in the range between 200 and 1000 nm, preferably between 300 and 1000 nm, particularly preferably between 300 and 950 nm, and very particularly preferably between 400 and 900 nm.
- one of the primary effects of phototherapy is the stimulation of metabolism in the mitochondria. After phototherapy, the cells show an increased metabolism, they communicate better and they survive stressful conditions in a better way.
- compositions according to the present invention can be used for cellular stimulation.
- Preferred wavelengths or ranges of wavelengths for cellular stimulation are in the range between 600 to 900 nm, particularly preferable between 620 and 880 nm, and very particularly preferably between 650 and 870 nm.
- Examples of particularly preferred wavelengths for cellular stimulation are 683.7, 667.5, 772.3, 750.7, 846, and 812.5 nm.
- any therapeutic disease and/or cosmetic condition approachable by phototherapy can be treated with compositions according to the present invention and opto-electronic devices, in particular OLECs, comprising them.
- diseases and/or conditions include, e.g., skin diseases, and skin-related conditions including skin-ageing, and cellulite, enlarged pores, oily skin, folliculitis, precancerous solar keratosis, skin lesion, aging, wrinkled and sun-damaged skin, crow's feet, skin ulcers (diabetic, pressure, venous stasis), acne rosacea lesions, cellulite; photomodulation of sebaceous oil glands and the surrounding tissues; reducing wrinkles, acne scars and acne bacteria, inflammation, pain, wounds, psychological and neurological related diseases and conditions, edema, Pagets disease, primary and metastatic tumors, connective tissue disease, manipulation of collagen, fibroblast, and fibroblast derived cell levels in mammalian tissue, illuminating retina,
- Cosmetic conditions are preferably selected from acne, skin rejuvenation and skin wrinkles, cellulite, and vitiligo. Many therapeutic treatments also have cosmetic component. Psoriasis, e.g., can be mild, mild-to-moderate, moderate, moderate-to-severe and severe. Any of these categories has a cosmetic component, which may be responsible for severe psychological problems of affected patients.
- compositions are used for the treatment and/or prophylaxis of humans and/or animals.
- composition according to the present invention is used for the treatment and/or prophylaxis of humans.
- compositions according to the present invention are plants, microbes, bacteria, fungi, and liquids.
- Microbes include, but are not limited to, prokaryotes such as bacteria and archaea and eukaryotes such as protists, animals, fungi and plants.
- Preferred liquids are beverages and particularly preferably water.
- the said organic electroluminescent compound can be selected from small molecules, polymers, oligomers, dendrimers, blends or mixtures thereof.
- the ionic species can be selected from small molecules, polymers, oligomers, dendrimers, blends or mixtures thereof.
- small molecule as used herein is defined as molecule not being a polymer, oligomer, dendrimer, or a blend. In particular, repeating structures are absent in small molecules.
- the molecular weight of small molecules is typically in the range of polymers with a low number of repeating units, oligomers or less. The molecular weight of the small molecule is preferably below
- the polymers of the present invention preferably have 10 to 10000, particularly preferably 20 to 5000 and very particularly preferably 50 to
- Oligomers according to this invention have preferably 2 to 9 repeat units.
- the branching index of the polymers and oligomers is between 0 (linear polymer without branching) and 1 (completely branched dendrimer).
- dendrimer as used herein is defined according to M. Fischer et al. in Angew. Chem., Int. Ed. 1999, 38, 885).
- the molecular weight (MW) of the polymers of the present invention is preferably in the range of 10000 to 2000000 g/mol, particularly preferably in the range of 100000 to 1500000 g/mol, and very particularly preferably in the range of 200000 to 1000000 g/mol.
- the determination of MW can be performed according to standard techniques known to the person skilled in the art by employing gel permeation chromatography (GPC) with polystyrene as internal standard, for instance.
- GPC gel permeation chromatography
- a blend is a mixture comprising at least one polymeric dendrimeric, or oligomeric component.
- compositions of the present invention may also comprise further compounds.
- One of the preferred further compounds is selected from hole transport materials (HTM).
- HTM is characterized in that it is a material or unit capable of transporting holes (i.e. positive charges).
- HTM hole transport materials
- a HTM is preferably selected from amines, triarylamines, thiophenes, carbazoles,
- HTM is particularly preferably selected from amines, triarylamines, thiophenes, carbazoles, phthalocyanines, and porphyrines.
- Suitable materials are phenylenediamine derivatives (US 3615404), arylamine derivatives (US 3567450), amino-substituted chalcone derivatives (US 3526501), styrylanthracene derivatives (JP A 56-46234), polycyclic aromatic compounds (EP 1009041), polyarylalkane derivatives (US 3615402), fluorenone derivatives (JP A 54-110837), hydrazone derivatives (US 3717462), stilbene derivatives (JP A 61-210363), silazane derivatives (US 4950950), polysilanes (JP A 2-204996), aniline
- aromatic tertiary amines containing at least two tertiary amine units such as, for example, 4,4'-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPD) (US 5061569) or MTDATA (JP A 4-308688), N,N,N',N , -tetra(4-biphenyl)diaminobiphenylene (TBDB), 1 ,1-bis(4-di-p-tolylaminophenyl)cyclohexane (TAPC), 1 ,1-bis(4-di- p-tolylaminophenyl)-3-phenylpropane (TAPPP), 1 ,4-bis[2-[4-[N,N-di(p- tolyl)amino]phenyl]vinyl]benzene (BDTAPVB), N,
- ETM electron transport materials
- An ETM refers to a material capable of transporting electrons (i.e. negative charges).
- any ETM known to one skilled in the art can be employed in compositions according to the present invention.
- Suitable ETMs are selected from the group consisting of imidazoles, pyridines, pyrimidines, pyridazines, pyrazines, oxadiazoles, chinolines, chinoxalines, anthracenes, benzanthracenes, pyrenes, pery- lenes, benzimidazoles, triazines, ketones, phosphinoxides, phenazines, phenanthrolines, triarylboranes, isomers and derivatives thereof.
- Suitable ETMs are metal chelates of 8 hydroxyquinoline (for example Liq, Alq 3 , Gaq 3 , Mgq 2 , Znq 2 , lnq 3 , Zrq 4 ), Balq, 4 azaphenanthrene-5-ol/Be complexes (US 5529853 A; e.g.
- anthracene-benzimidazole derivatives such as, for example, the compounds of Formulae (13) to (15), and as disclosed in, e.g., US 6878469 B2, US 2006/147747 A, and EP 1551206 A1.
- the said composition further comprises an ionic conductor, which is preferably selected from polymeric materials, such as perfluorosulfonic acid-based formulations, polybenzimidazoles, sulfonated polyetherketone, sulfonated naphthalenic polyimides, and polyethylene oxide (PEO)-based formulations.
- an ionic conductor which is preferably selected from polymeric materials, such as perfluorosulfonic acid-based formulations, polybenzimidazoles, sulfonated polyetherketone, sulfonated naphthalenic polyimides, and polyethylene oxide (PEO)-based formulations.
- PEO polyethylene oxide
- a very preferred ion conductor for the present invention is polyethylene oxide (PEO).
- the composition comprises 0 to 50 wt%, preferably 10 to 40 wt%, particularly preferably 10 to 30 wt%, and very particularly preferably 15 to 25 wt% of the HTM with respect to the composition.
- the composition comprises 0 to 50 wt%, preferably 10 to 40 wt%, particularly preferably 10 to 30 wt%, and very particularly preferably 15 to 25 wt% of the ETM with respect to the composition.
- the composition comprises one organic electroluminescent compound and separate ionic materials
- the composition comprises 0.1 to 20 wt%, preferably 1 to 15 wt%, particularly preferably 2 to 10 wt%, and very particularly preferably 5 to 10 wt% of the ionic species with respect to the composition and 20 to 99.9 wt%, preferably 20 to 80 wt%, particularly preferably 20 to 70 wt%, and very particularly preferably 20 to 50 wt% of the organic electroluminescent compound with respect to the composition.
- the composition further comprises at least one ion conductor compound which can have a concentration of 0 to 60 wt%, preferably 10 to 60 wt%, particularly preferably 20 to 50 wt%, and very particularly preferably 30 to 50 wt% with respect to the composition.
- the composition can comprise at least one ionic organic electroluminescent compound in form of K + A " , wherein either K + or A " is an organic emissive material.
- the composition comprises 3, particularly preferably 2, and very particularly preferably 1 compound of the formula K + A " .
- the composition preferably comprises further ion conducting material or a neutral matrix material, which can have a concentration of 0 to 70wt%, preferably 10 to 60 wt%, particularly preferably 10 to 40 wt%, and very particularly preferably 20 to 30 wt% with respect to the
- composition Preference is given to a composition, characterized in that the at least one of the organic electroluminescent compounds is selected from fluorescent emitter materials, phosphorescent emitter materials, and emissive organo metallic complexes.
- electroluminescent compound refers to a material which, upon receiving energy by applying a voltage, undergoes radiative decay to emit light.
- fluorescent emitter relates to materials or compounds which undergo a radiative transition from an excited singlet state to its ground.
- phosphorescent emitter as used herein, relates to luminescent materials or compounds which comprise transition metals. This typically includes materials emitting light caused by spin forbidden transition(s), e.g., transitions from excited triplet and/or quintet states.
- dopant as employed herein is also used for the term emitter, emitter material, or emissive material. Particular preference is given to organic electroluminescent compounds selected from fluorescent emitter.
- Emitter compounds tend to have an extended conjugated ⁇ -electron systems.
- Many examples have been published, e.g. styrylamine derivatives as disclosed in JP 2913116B and WO 2001/021729 A1 , and indenofluorene derivatives as disclosed in WO 2008/006449 and
- Blue fluorescent emitters are preferably polyaromatic compounds, such as, for example, 9,10-di(2-naphthylanthracene) and other anthracene derivatives, derivatives of tetracene, xanthene, perylene, such as, for example, 2,5,8,11-tetra-t-butylperylene, phenylene, for example 4,4'- (bis(9-ethyl-3-carbazovinylene)-1 , 1 '-biphenyl, fluorene, arylpyrenes (US 2006/0222886), arylenevinylenes (US 5121029, US 5130603), derivatives of rubrene, coumarine, rhodamine, quinacridone, such as, for example, ⁇ , ⁇ '-dimethylquinacridone (DMQA), dicyanomethylenepyrane, such as, for example, 4 (dicyanoethylene)-6-(4-dimethyla
- Preferred fluorescent dopants according to the present invention are selected from the class of the monostyrylamines, the distyrylamines, the tristyrylamines, the tetrastyrylamines, the styrylphosphines, the styryl ethers and the arylamines.
- a monostyrylamine is taken to mean a compound which contains one substituted or unsubstituted styryl group and at least one, preferably aromatic, amine.
- a distyrylamine is taken to mean a compound which contains two substituted or unsubstituted styryl groups and at least one, preferably aromatic, amine.
- a tristyrylamine is taken to mean a compound which contains three substituted or unsubstituted styryl groups and at least one, preferably aromatic, amine.
- a tetrastyrylamine is taken to mean a compound which contains four substituted or unsubstituted styryl groups and at least one, preferably aromatic, amine.
- the styryl groups are particularly preferably stilbenes, which may also be further substituted.
- the corresponding phosphines and ethers are defined analogously to the amines.
- an arylamine or an aromatic amine is taken to mean a compound which contains three substituted or unsubstituted aromatic or heteroaromatic ring systems bonded directly to the nitrogen. At least one of these aromatic or heteroaromatic ring systems is preferably a condensed ring system, preferably having at least 14 aromatic ring atoms.
- aromatic anthracene-amines are taken to mean a compound in which one diarylamino group is bonded directly to an anthracene group, preferably in the 9 position.
- aromatic anthracene- diamine is taken to mean a compound in which two diarylamino groups are bonded directly to an anthracene group, preferably in the 9,10- position.
- Aromatic pyrene-amines, pyrene-diamines, chrysene-amines and chrysene-diamines are defined analogously thereto, where the
- diarylamino groups on the pyrene are preferably bonded in the 1 position or in the 1 ,6-position.
- fluorescent dopants are selected from indenofluorene- amines and indenofluorene-diamines, for example in accordance with WO 2006/122630, benzoindenofluorene-amines and
- dopants from the class of the styrylamines are substituted or unsubstituted tristilbene-amines or the dopants described in
- distyrylbiphenyl derivatives are described in US 5121029. Further styrylamines are found in US 2007/0122656 A1.
- Particularly preferred styrylamine dopants and triarylamine dopants are the compounds of the Formulae (16) to (21) and as disclosed in
- fluorescent dopants are selected from the group of triarylamines as disclosed in EP 1957606 Aland US 2008/0113101 A1.
- fluorescent dopants are selected from derivatives of naphthalene, anthracene, tetracene, fluorene, periflanthene,
- indenoperylene indenoperylene, phenanthrene, perylene (US 2007/0252517 A1), pyrene, chrysene, decacyclene, coronene, tetraphenylcyclopentadiene,
- pentaphenylcyclopentadiene fluorene, spirofluorene, rubrene, coumarine (US 4769292, US 6020078, US 2007/0252517 A1), pyran, oxazone, benzoxazole, benzothiazole, benzimidazole, pyrazine, cinnamic acid esters, diketopyrrolopyrrole, acridone and quinacridone
- 9,10- substituted anthracenes such as, for example, 9,10-diphenylanthracene and 9,10-bis(phenylethynyl)anthracene.
- 1,4-Bis(9'- ethynylanthracenyl)benzene is also a preferred dopant.
- organic electroluminescent compounds selected from phosphorescent emitter.
- phosphorescent emitters examples include WO 00/70655, WO 01/41512, WO 02/02714, WO 02/15645, EP 1191613, EP 1191612, EP 1191614 and WO 2005/033244.
- all phosphorescent complexes as used in accordance with the prior art and as are known to the person skilled in the art in the area of organic electroluminescence are suitable, and the person skilled in the art will be able to use further phosphorescent complexes without inventive step.
- the phosphorescent emitter may be a metal complex, preferably with the formula M(L) Z , wherein M is a metal atom, L is in each occurrence independently of one another an organic ligand that is bonded to or coordinated with M via one, two or more positions, and z is an integer > 1 , preferably 1 , 2, 3, 4, 5 or 6, and wherein, optionally, these groups are linked to a polymer via one or more, preferably one, two or three positions, preferably via the ligands L.
- M is in particular a metal atom selected from transition metals, preferably selected from transition metals of group VIII, or lanthanoides, or actinides, particularly preferably selected from Rh, Os, Ir, Pt, Pd, Au, Sm, Eu, Gd, Tb, Dy, Re, Cu, Zn, W, Mo, Pd, Ag, or Ru, and very particularly preferably selected from Os, Ir, Ru, Rh, Re, Pd, or Pt. M may also be Zn.
- transition metals preferably selected from transition metals of group VIII, or lanthanoides, or actinides, particularly preferably selected from Rh, Os, Ir, Pt, Pd, Au, Sm, Eu, Gd, Tb, Dy, Re, Cu, Zn, W, Mo, Pd, Ag, or Ru, and very particularly preferably selected from Os, Ir, Ru, Rh, Re, Pd, or Pt.
- M may also be Zn.
- Preferred ligands are 2 phenylpyridine derivatives, 7,8-benzoquinoline derivatives, 2 (2-thienyl)pyridine derivatives, 2 (l-naphthyl)pyridine derivatives or 2 phenylquinoline derivatives. All these compounds may be substituted, for example by fluoro- or trifluoromethyl substituents for blue.
- Auxiliary ligands are preferably acetylacetonate or picric acid.
- Pt porphyrin complexes having an enlarged ring system (US 2009/0061681 A1) and Ir complexes are suitable, for example 2,3,7,8, 12, 13,17, 18-octaethyl-21 H, 23H-porphyrin- Pt(ll), tetraphenyl-Pt(ll)-tetrabenzoporphyrin (US 2009/0061681 A1), cis- bis(2-phenylpyridinato-N,C2')Pt(ll), cis-bis(2-(2'-thienyl)pyridinato- N,C3')Pt(ll), cis-bis(2-(2'-thienyl)quinolinato-N,C5
- N,C2')iridium(lll) bis(2-phenylpyridinato-N,C2')(1-phenylisoquinolinato- N,C2')iridium(lll), bis(2-(2'-benzothienyl)pyridinato-N,C3')iridium(lll) acetylacetonate, bis(2-(4',6'-difluorophenyl)pyridinato-N,C2')iridium(lll) piccolinate (Firpic, blue), bis(2-(4',6'-difluorophenyl)pyridinato-N,C2')lr(lll) tetrakis(1-pyrazolyl)borate, tris(2-(biphenyl-3-yl)-4-tert- butylpyridine)iridium(lll), (ppz) 2 lr(5phdpym) (US 2009/
- phenylpyridine-lr complexes such as, for example, iridium(lll) bis(2- phenylquinolyl-N,C2')acetylacetonate (PQIr), tris(2-phenylisoquinolinato- N,C)lr(lll) (red), bis(2-(2'-benzo[4,5-a]thienyl)pyridinato-N,C3)lr acetylacetonate ([Btp2lr(acac)], red, Adachi et al. Appl. Phys. Lett. 78 (2001), 1622-1624).
- PQIr iridium(lll) bis(2- phenylquinolyl-N,C2')acetylacetonate
- PQIr iridium(lll) bis(2- phenylquinolyl-N,C2')acetylacetonate
- PQIr iridium(lll)
- a particularly preferred phosphorescent dopant is a compound with the Formula (23) and further compounds as disclosed, e.g., in
- a particularly preferred phosphorescent dopant is a compound with the Formula (24) and further compounds as disclosed, e.g., in
- organic electroluminescent compounds selected from organo metallic complexes.
- a suitable metal complex according to the present invention can be selected from transition metals, rare earth elements, lanthanides and actinides is also subject of this invention.
- the metal is selected from Ir, Ru, Os, Eu, Au, Pt, Cu, Zn, Mo, W, Rh, Pd, or Ag.
- the organic electroluminescent compound emits in ultraviolet (UV) range.
- Suitable UV emitter materials can be selected from organic compounds comprising a wide-gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) moieties with a small ⁇ -conjugated system.
- Such UV emitter can be preferably selected from small molecular compounds comprising carbazoles, indenocarbazole, indolocarbazole, silane, fluorene, triazine, thiophene, dibenzothiophene, furane, dibenzofurane, imidazole, benzimidazole, anthracene, naphthalene, phenanthrene, amine, triarylamine and derivatives theirof.
- the suitable UV emitter can be selected from polymeric materials which have a limited conjugated length, for example a spiro-bifluorene polymer as reported by Wong, Ken Tsung et al. (Org. Lett. 2005, 7, 5131) and fluorene polymers as reported by Chao, Teng Chih, et al. (Adv. Mater. (Weinheim, Ger.) 2005, 17, 992).
- the polymeric UV emitter materials are selected from non- conjugated polymers, which comprises the small molecular UV emitter as described above.
- the suitable non-conjugated polymer can be a side- chain polymer with emitter and other functional groups on the side-chains, as, for example, disclosed in JP 2005/108556, JP 2005/285661 ,
- the organic electroluminescent compound may also be a polymer, oligomer, dendrimer, and blend.
- the polymer may also have further functions such as charge transfer transport function. Therefore, the present inventions also relates to compositions comprising further polymeric molecules.
- the said polymer comprises units, which are preferably selected from the groups comprising phosphorescent emitter, particularly emissive metal complexes as described above. Particular preference is given here to corresponding structural units which contain elements from groups 8 to 10 (Ru, Os, Rh, Ir, Pd, Pt).
- the functions are, inter alia, the ones of a hole injection material, hole transport material, emissive material, electron injection material, and electron transport material.
- the functions which are incorporated into a polymer can be categorized into different groups. By choosing the desired functional groups and the ratio between them, the polymer can be tuned to have the desired function(s).
- the difference between polymers, oligomers and dendrimers is due to the size, size distribution, and branching of the molecular entities as defined above.
- Different structures are, inter alia, those as disclosed and extensively listed in WO 2002/077060 A1 and in DE 10337346 A1.
- the structural units may originate, for example, from the following groups: Group 1 : units which increase the hole-injection and/or transport
- Group 2 units which increase the electron-injection and/or transport
- Group 3 units which have combinations of individual units from group 1 and group 2;
- Group 4 units which modify the emission characteristics to such an
- electrophosphorescence may be obtained instead of electrofluorescence; typically, it corresponds to the
- phosphorescent emitter or more preferably emissive metal complexes as described above.
- Group 5 units which improve the transition from the so called singlet state to higher spin states, e.g. to a triplet state;
- Group 6 units which influence the morphology and/or emission colour of the resultant polymers
- Group 7 units which are typically used as backbone and which may have electron transport function, hole transport function or both.
- the polymer is a hole transport or injection polymer comprising units of groups 1 , which are preferably selected from units comprising the low molecular weight HTMs or HIMs as described above.
- Further preferred units from group 1 are, for example, triarylamine, benzidine, tetraaryl-para-phenylenediamine, carbazole, azulene, thiophene, pyrrole and furan derivatives and further O, S, or N containing heterocycles.
- Preferred polymeric HTM or HIM is a polymer comprising at least one of following repeat unit according to Formulae (25).
- Ar 1 which may be the same or different, denote, independently if in different repeat units, a single bond or an optionally substituted mononuclear or polynuclear aryl group,
- Ar 2 which may be the same or different, denote, independently if in different repeat units, an optionally substituted mononuclear or polynuclear aryl group,
- Ar 3 which may be the same or different, denote, independently if in different repeat units, an optionally substituted mononuclear or polynuclear aryl group, m is 1 , 2 or 3.
- Particularly preferred units of Formula (25) are selected from the group consisting of the Formulae (26) to (28):
- R which may be the same or different in each occurrence, is selected from H, substituted or unsubstituted aromatic or heteroaromatic group, alkyl, cycloalkyl.alkoxy, aralkyl, aryloxy, arylthio, alkoxycarbonyl, silyl, carboxy group, a halogen atom, cyano group, nitro group or hydroxy group, r is 0, 1 , 2, 3 or 4, and s is 0, 1 , 2, 3, 4 or 5.
- polymeric HTM or HIM is a polymer comprising at least one of following repeat unit according to Formulae (29).
- T 1 and T 2 are independently of each other selected from thiophene, selenophene, thieno[2,3b]thiophene, thieno[3,2b]thiophene,
- Ar 4 and Ar 5 are independently of each other mononuclear or polynuclear aryl or heteroaryl, which is optionally substituted and optionally fused to the 2,3-positions of one or both of the adjacent thiophene or selenophene groups, c and e are independently of each other 0, 1 , 2, 3 or 4, with 1 ⁇ c + e ⁇ 6, d and f are independently of each other 0, 1 , 2, 3 or 4.
- polymeric HTMs are as disclosed in WO 2007131582 A1 and WO 2008/009343A1.
- the said polymer comprises units of groups 2, which are preferably selected from groups comprising the low molecular weight ETMs or EIMs as described above.
- Further preferred units from group 2, which have electron-injection or electron-transport properties are, for example, pyridine, pyrimidine, pyridazine, pyrazine, oxadiazole, quinoline, quinoxaline and phenazine derivatives, but also triarylboranes and further O, S, or N containing heterocycles.
- the said polymer comprises units from group 3 in which structures which increase the hole mobility and the electron mobility (i.e. units from groups 1 and 2) are bonded directly to one another. Some of these units may serve as emitters and shift the emission colour into the green, yellow or red. Their use is thus suitable, for example, for the production of other emission colours or a broad-band emission from originally blue-emitting polymers.
- the polymer comprises units of group 4, which are preferably selected from the groups comprising phosphorescent emitter, particularly emissive metal complexes as described above. Particular preference is given here to corresponding structural units which contain elements from groups 8 to 10 (Ru, Os, Rh, Ir, Pd, Pt).
- the said polymer comprises units of group 5, which can improve the transition from the singlet state to the triplet state and which, employed in support of the structural elements from group 4, improve the phosphorescence properties of these structural elements.
- groups 5 which can improve the transition from the singlet state to the triplet state and which, employed in support of the structural elements from group 4, improve the phosphorescence properties of these structural elements.
- Suitable for this purpose are, in particular, carbazole and bridged carbazole dimer units, as described in DE 10304819 A1 and DE 10328627 A1.
- Further preferred structure units can be selected from groups comprising the low molecular weight phosphorescent matrices as described above.
- the said polymer comprises units of group 6, which influence the morphology and/or emission colour of the polymers, are, besides those mentioned above, those which have at least one further aromatic or another conjugated structure which do not fall under the above-mentioned groups, i.e. which have only little effect on the charge-carrier mobilities, which are not organometallic complexes or which have no influence on the singlet-triplet transition.
- Structural elements of this type may influence the morphology and/or emission colour of the resultant polymers. Depending on the unit, they can therefore also be employed as emitters.
- aromatic structures having 6 to 40 C atoms or also tolan, stilbene or bisstyrylarylene derivatives, each of which may be substituted by one or more radicals R 1 .
- Particular preference is given here to the incorporation of 1 ,4-phenylene, 1 ,4-naphthylene, 1 ,4- or 9,10-anthrylene, 1 ,6-, 2,7- or 4,9-pyrenylene, 3,9- or 3,10-perylenylene, 4,4'-biphenylylene, 4,4"-terphenylylene, 4,4' bi 1 ,1 -naphthylylene, 4,4'-tolanylene, 4,4'- stilbenylene or 4,4"-bisstyrylarylene derivatives.
- the said polymer comprises units of group 7 which contain aromatic structures having 6 to 40 C atoms which are typically used as polymer backbone.
- aromatic structures having 6 to 40 C atoms which are typically used as polymer backbone.
- These are, for example, 4,5-dihydropyrene derivatives, 4,5,9, 10-tetrahydropyrene derivatives, fluorene derivatives as disclosed for example in US 5962631 , WO 2006/052457 A2 and
- WO 2006/118345A1 9,9'-spirobifluorene derivatives as disclosed for example in WO 2003/020790 A1 , 9,10-phenanthrene derivatives as disclosed, for example, in WO 2005/104264 A1 , 9,10- dihydrophenanthrene derivatives as disclosed for example in
- WO 2004041901 A1 WO 2004113412 A2 and , binaphthylene derivatives as disclosed for example in WO 2006/063852 A1 , and further units as disclosed for example in WO 2005/056633A1 , EP 1344788A1 and
- Very preferred structural elements of group 7 are those of Formula (30):
- R° and R 00 are independently of each other H or an optionally substituted carbyl or hydrocarbyl group optionally comprising one or more hetero atoms, each g is independently 0 or 1 and each corresponding h in the same subunit is the other of 0 or 1 , m is an integer > 1
- Ar 1 and Ar 2 are independently of each other mono- or polynuclear aryl or heteroraryl that is optionally substituted and optionally fused to the 7,8- positions or 8,9-positions of the indenofluorene group, a and b are independently of each other 0 or 1.
- the groups R and R 2 form a spiro group with the fluorene group to which they are attached, it is preferably spirobifluorene.
- the groups of Formula (30) are preferably selected from the following Formulae (31) to (35):
- R is as defined in Formula (30), r is 0, 1 , 2, 3 or 4, and R has one of the meanings of R 1 .
- L is H, halogen or optionally fluorinated, linear or branched alkyl or alkoxy with 1 to 12 C atoms, and is preferably H, F, methyl, i-propyl, t-butyl, n- pentoxy, or trifluoromethyl, and
- L' is optionally fluorinated, linear or branched alkyl or alkoxy with 1 to 12 C atoms, and is preferably n-octyl or n-octyloxy.
- polymers suitable for use in the invention which simultaneously comprise one or more units selected from groups 1 to 8. It may likewise be preferred for more than one structural unit from a group to be present simultaneously.
- polymers suitable for use in the invention which, besides structural units of an emitter, also comprise at least one structural unit from the above-mentioned groups. At least two structural units are particularly preferably from different classes of those mentioned above.
- the proportion of the different classes of groups, if present in the polymer, is preferably in each case at least 5 mol%, particularly preferably in each case at least 10 mol%.
- one of these structural units is selected from the group of hole-conducting units and the other group is an emitting unit, where these two functions (hole conduction and emission) may also be taken on by the same unit.
- a smaller proportion of the emitting units in particular green- and red-emitting units, may also be preferred, for example for the synthesis of white-emitting copolymers.
- white-emitting copolymers The way in which white-emitting copolymers can be synthesised is described in detail in DE 10343606 A1.
- individual C atoms of these may be replaced by O or S.
- the said polymer may be statistical or random copolymers, alternating or regioregular copolymers, block copolymers or combinations thereof.
- the said polymer is a side-chain non- conjugated polymer, which is especially important for phosphorescent emission based on polymer.
- phosphorescent polymer is obtained by means of radical copolymerization of vinyl compounds, and comprises at least one phosphorescent emitter and at least one charge transport unit on side chain, as disclosed in US 7250226 B2. Further examples for such phosphorescent polymer are disclosed for example in JP 2007/211243 A2, JP 2007/197574 A2, US 7250226B2,
- the said polymer is a main-chain non- conjugated polymer, where the backbone units are connected by spacer on main-chain. Like side-chain non-conjugated polymer, main-chain non- conjugated polymers give also a high triplet level.
- An example for triplet OLEDs based on main-chain non-conjugated polymers is disclosed in DE 102009023154.4.
- the said polymer can also be a non-conjugated polymer for fluorescent emission.
- Preferred singlet non-conjugated polymers are, for example, side-chain polymers with antracenenes, benzanthrecenes and their derivates in the side-chain, as disclosed in JP 2005/108556, JP 2005/285661, JP 2003/338375 etc..
- the said polymers can also act as ETM or HTM, preferably the polymer is a non-conjugated polymer.
- Typical ionic species also called ionic materials, which are suitable for the composition and the devices according to the present invention, have the general formula K + A " , wherein K + and A " represent a cation and an anion, respectively.
- the ionic materials are soluble in the same solvent as the organic emissive material. This easily allows the preparation of a mixture comprising the said emitter material(s) and the ionic material(s).
- organic emissive materials are soluble in common organic solvents, such as toluene, anisole, chloroform.
- the said ionic material is solid at room temperature and particularly preferably, the said ionic material is solid at room temperature and getting softer between 30 to 37°C.
- Suitable inorganic cations K + can be selected from, for example, K + (potassium) and Na + .
- Suitable organic cations K + can be selected from ammonium-, phosphonium, thiouronium-, guanidinium cations as shown in Formulae (40) to (44) or heterocyclic cations as shown in Formulae (45) to (72).
- R 1 to R 6 can be, independently from each other, selected from linear or hyperbranched alkyl rests with 1 to 20 C-atoms, linear or hyperbranched alkenyl rests with 2 to 20 C-atoms and one or more non-conjugated double bonds, linear or hyperbranched alkinyl rests with 2 to 20 C-atoms and one or more non-conjugated triple bond, saturated, partly saturated or completely saturated cycloalkyl with 3 to 7 C-atoms, which can further be substituted with alkyl groups having 1 to 6 C-atoms, wherein one or more substituents R may be partly or completely substituted with halogen, particularly with -F and/or -CI, or partly substituted with -OR', -CN, - C(O)OH, -C(O)NR' 2 , -SO 2 NR' 2) -SO 2 OH, -SO 2 X, -NO 2 , wherein one or two non adjacent and non a-carbon atoms of R 1 to
- R 1 to R 4 can be H, with the provision that at least one of the rests R to R 4 is not H.
- R 1 to R 4 can be H and NR' 2) wherein R' is defined as above.
- R 1 to R 5 can be H.
- R 1 to R 6 can be H, CN, and NR' 2 , wherein R' is defined as above.
- substituents R 1 , to R 4 ' are independently from each other selected from H, CN, linear and branched alkyl rest with 1 to 20 C-atoms, linear or branched alkenyl rest with 2 to 20 C-atoms and one or more non conjugated double bonds, linear or branched alkinyl rest with 2 to 20 C- atoms and one or more non conjugated triple bonds, partly or completely non saturated cycloalkyi rest with 3 to 7 C-atoms which can be substituted with alkyl rests with 1 to 6 C-atoms, saturated and partly or completely non saturated heteroaryls, heteroaryl-Ci-C6-alkyl, or alkyl-CrC 6 -alkyl, wherein the substituents R 1 ', R 2 ', R 3 ' and/or R 4 ' together can form a ring, wherein one or more of the substituents R ' to R 4 ' can partly or completely be substituted with halogen, particularly with -F and/or R
- R 2 selected from -OR'.-NR ⁇ , -C(O)OH, -C(O)NR' 2 , -SO 2 NR' 2 ) -SO 2 OH, - SO 2 X, and -NO 2 .
- Further preferred ionic materials are disclosed in, e.g., US 2007/0262694 A1. Further particularly preferred ionic materials comprise a cation having a structure represented by Formula (73). They include ⁇ , ⁇ , ⁇ -trimethylbutyl ammonium ion, N-ethyl-N,N-dimethyl-propyl ammonium ion, N-ethyl-N,N- dimethylbutyl ammonium ion, N,N,-dimethyl-N-propylbutyl ammonium ion, N-(2-methoxyethyl)-N,N-dimethylethyl ammoniumion, 1 -ethyl-3-methyl imidazolium ion, 1-ethyl-2,3-dimethyl imidazoliun ion, 1-ethyl-3,4-dimethyl imidazolium ion, 1-ethyl-2,3,4-trimethyl imidazolium ion,
- N-methyl-N-propyl piperidinium is N-methyl-N-propyl piperidinium.
- Particularly preferred ionic material is a compound selected from the group of ionic compounds, which are soluble in common organic solvents such as toluene, anisole, and chloroform, consisting of
- methyltrioctylammonium trifluoromethane-sulfonate (MATS), 1-methyl-3- octylimidazolium octylsulfate, 1-butyl-2,3-dimethylimidazolium octylsulfate, 1 -octadecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, 1 - octadecyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, 1 ,1-dipropylpyrrolidimium bis(trifluoromethylsulfonyl)imide,
- composition and device according to the present invention is a compound wherein one of K + or A " is covalently bounded to a polymer backbone.
- ionic materials suitable for the composition and device according to the present invention are selected from compounds wherein one of K + or A " is an organic emissive material, which can be selected from small molecule and polymeric emissive materials as described elsewhere within the present invention.
- Suitable anions A " can be selected from [HS0 4 ] “ , [S0 4 ] 2" , [N03] “ ,[BF 4 ] “ , [(R F )BF3r, [(R F ) 2 BF 2 r,
- the alkyl-group mentioned above can be selected from linear or hyperbranched alkyl groups with 1 to 20 C-atoms, preferably with 1 to 14 C-atoms and particularly preferably with 1 to 4 C-atoms.
- R F means CF 3 , C 2 F 5 , C 3 F 7 or C 4 F 9 .
- Preferred anions are selected from PF 6 " , [PF 3 (C 2 F 5 ) 3 ] " , [PF 3 (CF 3 ) 3 ] ⁇ , BF 4 ⁇ , [BF 2 (CF 3 ) 2 r, [BF 2 (C 2 F 5 )2l “ , [BF 3 (CF 3 )r, [BF 3 (C 2 F 5 )r, [B(COOCOO) 2 " (BOB “ ), CF 3 SO 3 (Tf), C 4 F 9 SO 3 (Nf), [(CF 3 SO 2 ) 2 Nr(TFSr), [(C 2 F 5 S0 2 ) 2 N]- ( ⁇ ), [(CF 3 SO 2 )(C 4 F 9 SO 2 )N] ⁇ [(CN) 2 N] “ (DCA ), [CF 3 SO 2 ] 3 C] " , and
- n. m a, b are 1.
- One particular advantage of such composition is that no additional ionic compound is needed.
- K n+ or A m" is an emissive metal complex
- K n+ is an emissive metal complex
- the metal can be selected from transition metals, preferably those of group VIII elements, lanthanides, and actinides, particularly preferably selected from Rh, Os, Ir, Pt, Au, Sm, Eu, Gd, Tb, Dy, Re, Cu, W, Mo, Pd, Ag, Ru, and very particularly preferably selected from Ru, Os, Ir, Re.
- the said composition comprises a compound with the formula (K n+ ) a (A m" ) b , wherein one of K n+ or A m" is an emissive singlet emitter, and particularly preferably K n+ an emissive singlet emitter.
- K n+ or A m" is an emissive singlet emitter, and particularly preferably K n+ an emissive singlet emitter.
- Such kind of compound can be selected from charged laser dyes, for examples p-quaterphenyl-4,4'"-disulfonicacid disodiumsalt (polyphenyl 1), p-quaterphenyl-4,4'"-disulfonicacid
- Another subject of the present invention is a light emitting device comprising a composition comprising at least one compound of the formula (K n+ ) a (A m" ) b , characterized in that one of K n+ or A m" is an emissive singlet emitter.
- K n+ is an emissive singlet emitter.
- K n+ is preferably selected from the group as defined above.
- the light emitting device is a electroluminescent device.
- a device comprising said composition comprising 3, particularly preferably 2, and very particularly preferably 1 compound of said formula (K n+ ) a (A m" ) b .
- the said device comprises at least two electrodes. Preferably it comprises two electrodes, a cathode and an anode. In a preferred embodiment both electrodes are connected by said composition.
- the device comprising a composition comprising a compound of formula (K n+ ) a (A m" ) b
- compositions according to the present invention may also comprise at least one host material.
- Host materials are usually used in combination with emitter and have, in general, larger energy gaps between the HOMO and the LUMO as compared to emitter materials.
- host materials behave either as electron or hole transport material.
- Host materials can also have both electron and hole transport properties.
- a host material is also called matrix or matrix material, particularly if a host is meant which is used in combination with a phosphorescent emitter.
- the polymer backbone acts as a host.
- any host material known to one skilled in the art can be employed according to the present invention.
- host materials can be separated into two categories, hosts for fluorescent emitter and hosts for phosphorescent emitter (also called matrix material).
- host materials selected from anthracenes, benzan- thracenes, indenofluorenes, fluorenes, spirobifluorenes, phenanthrenes, dehydrophenanthrenes, thiophenes, triazines, imidazole, ketones, carbazoles, indolocarbazoles, indenocarbazoles, triarylamines, and derivatives thereof.
- host materials selected from anthracenes, benzanthracenes, indenofluorenes, fluorenes, spirobifluorenes, phenan- threnes, dehydrophenanthrenes, thiophenes, triazines, imidazole, ketones, carbazoles, indolocarbazoles, indenocarbazoles, and
- composition and/or device according to the present invention may also comprise more than one host material, preferably it comprises 3 host materials, particularly preferably it comprises 2 host materials, and very particularly preferably one host material. If a composition according to the present invention comprises at least two host materials, the host materials are also referred to as co-hosts or co-host materials.
- Preferred host materials suitable for fluorescent emitter are selected from anthracenes, benzanthracenes, indenofluorenes, fluorenes, spirobifluorenes, phenanthrenes, dehydrophenanthrenes, thiophenes, triazines, imidazole indolocarbazoles, indenocarbazoles, and derivatives thereof.
- Preferred host materials suitable for fluorescent emitter are selected from anthracenes, benzanthracenes, indenofluorenes, fluorenes, spirobifluorenes, phenanthrenes, dehydrophenanthrenes, thiophenes, triazines, imidazole, indolocarbazoles, and indenocarbazoles.
- Particularly preferred host materials for fluorescent emitter are selected from the classes of the oligoarylenes (for example 2,2',7,7'-tetraphenyl- spirobifluorene in accordance with EP 676461 or dinaphthylanthracene), in particular the oligoarylenes containing condensed aromatic groups, such as, for example, phenanthrene, tetracene, coronene, chrysene, fluo- rene, spirofluorene, perylene, phthaloperylene, naphthaloperylene, deca- cyclene, rubrene, the oligoarylenevinylenes (for example 4,4'-bis(2,2-di- phenylethenyl)-1 , 1 '-biphenyl (DPVBi) or 4,4-bis-2,2-diphenylvinyl-1 , 1 - spirobiphenyl (spiro-DPVBi) in accord
- the electron-conducting compounds in particular ketones, phosphine oxides, sulfoxides, etc. (for example in accordance with WO 2005/084081 and WO 2005/084082), the atropisomers (for example in accordance with
- WO 2006/048268 the boronic acid derivatives (e.g. WO 2006/117052) or the benzanthracenes (e.g. DE 102007024850).
- Particularly preferred host materials are selected from the classes of the oligoarylenes, containing naphthalene, anthracene, benzanthracene and/or pyrene, or atropisomers of these compounds, the ketones, the phosphine oxides and the
- oligoarylene containing anthracene, benzanthracene and/or pyrene, or atropisomers of these compounds.
- an oligoarylene is intended to be taken to mean a
- Q Further preferred host materials for fluorescent emitter are selected, in particular, from compounds of the Formula 80
- the group Ar 5 it is particularly preferred in the host materials of the Formula 80 for the group Ar 5 to stand for anthracene, which may be substituted by one or more radicals R 1 , and for the groups Ar 4 and Ar 6 to be bonded in the 9 and 10-positions.
- at least one of the groups Ar 4 and/or Ar 6 is a condensed aryl group selected from 1- or 2-naphthyl, 2-, 3- or 9-phenanthrenyl or 2-, 3-, 4-, 5-, 6- or 7-benzanthracenyl, each of which may be substituted by one or more radicals R 1 .
- Anthracene-based compounds are described in US 2007/0092753 A1 and US 2007/0252517
- A1 for example 2-(4-methylphenyl)-9,10-di-(2-naphthyl)anthracene, 9-(2- naphthyl)-10-(1 ,1'-biphenyl)anthracene and 9,10-bis[4-(2,2-diphenyl- ethenyl)phenyl]anthracene, 9, 0-diphenylanthracene, 9,10-bis(phenyl- ethynyl)anthracene and 1 ,4-bis(9'-ethynylanthracenyl)benzene.
- Further preferred host materials are derivatives of arylamine, styrylamine, fluorescein, perynone, phthaloperynone, naphthaloperynone, diphenyl- butadiene, tetraphenylbutadiene, cyclopentadienes, tetraphenylcyclo- pentadiene, pentaphenylcyclopentadiene, coumarine, oxadiazole, bis- benzoxazoline, oxazone, pyridine, pyrazine, imine, benzothiazole, benz- oxazole, benzimidazole (US 2007/0092753 A1), for example 2,2',2"- (1 ,3,5-phenylene)tris[1-phenyl-1 H-benzimidazole], aldazines, stilbene, styrylarylene derivatives, for example 9,10-bis[4-(2,2-diphenylethenyl)-
- derivatives of arylamine and styrylamine for example 4,4'-bis[N-(1-naphthyl)-N-(2-naphthyl)amino]biphenyl (TNB).
- Preferred compounds with oligoarylene as hosts for fluorescent emitter are compounds as disclosed in, e.g., US 2003/0027016 A1 , US 7326371 B2, US 2006/043858 A, US 7326371 B2, US 2003/0027016 A1 ,
- Particularly preferred oligoarylene-based compounds are compounds having the Formulae (81) to (87).
- Further host materials for fluorescent emitter can be selected from spirobifluorene and derivates thereof, for example Spiro-DPVBi as disclosed in EP 0676461 and indenofluorene as disclosed in US 6562485.
- the preferred host materials for phosphorescent emitter i.e. matrix materials, are selected from ketones, carbazoles, indolocarbazoles, triaryl- amines, indenofluorenes, fluorenes, spirobifluorenes, phenathrenes, de- hydrophenanthrenes, thiophenes, triazines, imidazoles and their derivatives. Some preferred derivatives are described below in more details.
- the host material must fulfil rather different characteristics as compared to host materials used for fluorescent emitter.
- the host materials used for phosphorescent emitter are required to have a triplet level which is higher in energy as compared to the triplet level of the emitter.
- the host material can either transport electrons or holes or both of them.
- the emitter is supposed to have large spin-orbital coupling constants in order to facilitate singlet-triplet mixing sufficiently. This can be enabled by using metal complexes.
- Preferred matrix materials are ⁇ , ⁇ -biscarbazolylbiphenyl (CBP), carbazole derivatives (e.g.
- WO 2005/039246 US 2005/0069729, JP 2004/288381 , EP 1205527 or DE 102007002714
- azacarbazoles e.g. EP 1617710, EP 1617711 , EP 1731584, JP 2005/347160
- ketones for example in accordance with WO 2004/093207
- phosphine oxides for example in accordance with WO 2005/003253
- oligophenyl- enes aromatic amines
- bipolar matrix materials for example in accordance with WO 2007/137725
- silanes for example in accordance with WO 2005/111172
- 9,9-diarylfluorene derivatives e.g. in accordance with DE 102008017591
- azaboroles or boronic esters for example in accordance with WO 2006/117052
- triazole derivatives oxa- zoles and oxazole derivatives, imidazole derivatives, polyarytalkane derivatives, pyrazoline derivatives, pyrazolone derivatives, distyrylpyrazine derivatives, thiopyran dioxide derivatives, phenylenediamine derivatives, tertiary aromatic amines, styrylamines, indoles, anthrone derivatives, fluorenone derivatives, fluorenylidenemethane derivatives, hydrazone derivatives, silazane derivatives, aromatic dimethylidene compounds, porphy
- Preferred Si tetraaryl compounds are, for example, (US 2004/0209115, US 2004/0209116, US 2007/0087219 A1 , US 2007/0087219 A1) the compounds of the Formulae (100) to (105).
- a particularly preferred matrix for phosphorescent dopants is the compound of Formula (106) (EP 652273 B1)
- M is Zn
- L is quinolinate
- n is 2, 3 or 4.
- M is Zn
- L is quinolinate
- n is 2, 3 or 4.
- co-hosts selected from metal oxinoid complexes whereby lithium quinolate (Liq) or Alq 3 are particularly preferred.
- composition according to the present invention for the treatment and/or prophylaxis of skin diseases and/or-skin related conditions are also subject of the present invention.
- composition of the present invention is used for the treatment and/or prophylaxis of skin diseases and/or-skin related conditions.
- Skin as used herein is defined as the largest organ of the integumentary system including hair, scales, feathers and nails.
- the term skin also includes the tongue, mucosa and gingival.
- any therapeutic and cosmetic condition that is approachable by phototherapy is covered by the present invention.
- the distinction between the terms therapeutic and cosmetic depends, as outlined above, on individual circumstances, the severity of the condition and the assessment of the physician. As outlined in this invention many
- the skin diseases and skin related conditions include, but are not limited to acneiform eruptions, autoinflammatory skin diseases or conditions, chronic blistering, conditions of the mucous membranes, conditions of the skin appendages, conditions of the subcutaneous fat, connective tissue diseases, abnormalities of dermal fibrous and elastic tissue, dermal and subcutaneous growths, dermatitis, atopic dermatitis, contact dermatitis, eczema, pustular dermatitis, seborrheic dermatitis and eczema, disturbances of pigmentation, drug eruptions, endocrine-related diseases and conditions, epidermal nevi diseases and conditions, neoplasms, cysts, erythemas, genodermatoses, infection-related diseases and conditions, bacterium-related diseases and conditions, mycobacterium- related diseases and conditions, mycosis-related diseases and
- Skin related diseases and conditions also include skin tumors, pre- malignant tumors, malignant tumors, cell carcinomas, secondary metastasis, radiodermatitis and keratosis.
- wound healing can also be assigned to skin diseases and skin related conditions. Wound healing can, hereby, occur at the outer surface of the subject to be treated, at its internal parts, at the skin, eye, nail or nail bed, any surface in the subject's mouth, and at the mucosa, gingival, epithelial surface of the vascular system or other part of the subjects body.
- the compositions according to the present invention can be used in cosmetics for skin care and skin repair, e.g. as light plaster.
- wavelengths or range of wavelengths emitted by said compositions is in the range between 400 and 800 nm, preferably between 450 and 750 nm, particularly preferably between 500 and 700 nm, and very particularly preferably between 580 and 640nm.
- Preferred skin diseases and skin-related conditions are selected from acne, psoriasis, eczema, edema, dermatitis, atopic dermatitis, vitiligo,
- Bowens disease tumors, pre-malignant tumors, malignant tumors, basal cell carcinomas, squamous cell carcinomas, secondary metastases, cutaneous T-cell lymphomas, solar keratosis, arsenical keratosis, radiodermatitis, and cellulite
- Further preferred skin diseases and skin-related conditions are selected from psoriasis, polymorphous light eruption, solar urticaria, actinic reticuloid atopic eczema, vitiligo, pruritus, lichen planus, early cutaneous T-cell lymphoma, dermographism, and pityriasis lichenoides.
- theses diseases and conditions are treated with light having a wavelength or a range of wavelengths between 200 and 500 nm, particularly preferably between 250 and 400 nm, and very particularly preferably between 270 and 350 nm.
- the compositions of the present invention can be used for PUVA therapy.
- PUVA therapy is derived from the therapeutic application of psoralen (7H- furo[3,2-g]chromen-7-one) and derivatives thereof together with UV-A light.
- PUVA can be employed for the treatment of skin diseases
- Psoralen is the parent compound in a family of natural products. It is structurally related to coumarines and can preferably be used for the treatment of psoriasis, eczema, vitiligo, mycosis fungoides, cuntaneous T-cell lymphoma, and other autoimmune diseases. With PUVA can also bet treated atopic eczema, lichen planus, urticaria pigmentosa, polymorphous light eruption, and alopecia areata. Psoralen can be administered orally or topically to the skin.
- Preferred compounds are psoralen, 8-methoxypsoralen (8-MOP), 5- methoxypsoralen (5-MOP), and 4,5', 8-trimethylpsoralen (TMP).
- 8-MOP 8-methoxypsoralen
- 5-MOP 5- methoxypsoralen
- TMP 4,5', 8-trimethylpsoralen
- vitiligo khellin can be used instead of psoralen.
- the combined treatment with light and khellin is often called KUVA.
- compositions of the present invention and devices comprising them can also be used for photopheresis.
- Photophoreresis is a process by which peripheral blood is exposed in an extracorporeal flow system to photoactivate 5-MOP and represents a treatment for disorders caused by aberrant T lymphocytes. It is a therapy for advanced cutaneous T-cell lymphoma, pemphigus vulgaris and progressive systemic sclerosis
- scleroderma (scleroderma). It can be used to treat autoimmune disorders.
- Furtehr diseases that can be treated include multiple sclerosis, organ transplant rejection, rheumatoid arthritis, and AIDS.
- the present invention particularly refers to compositions according to the present invention for the treatment of acneiform eruptions.
- acneiform eruption refers to a group of dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis.
- Acneiform eruptions are, generally spoken, caused by changes in the pilosebaceous unit and are selected from acne aestivalis (Mallorca acne), acne conglobata, acne cosmetica, acne fulminans (acute febrile ulcerative acne), acne keloidalis (acne keloidalis nuchae, dermatitis papillaris capillitii, folliculitis keloidalis, folliculitis keloidis nuchae, nuchal keloid acne), acne mecanica, acne medicamentosa, acne miliaris necrotica (acne varioliformis), acne vulgaris, acne with facial edema (solid facial edema), acneiform eruptions, blepharophyma, erythrotelangiectatic rosacea (erthemaotelangiectatic rosacea), excoriated acne (acne excoriee des de filles, Picker's acne), glandular rosacea, gnathophyma,
- granulomatous rosacea micropapular tuberculid, rosacea-like tuberculid of Lewandowsky
- lupus miliaris disseminatus faciei metophyma
- neonatal acne acne infantum, acne neonatorum
- occupational acne ophthalmic rosacea (ocular rosacea, ophthalmorosacea), otophyma, persistent edema of rosacea (chronic upper facial erythematous edema, Morbihan's disease, Rosaceous lymphedema), pomade acne,
- papulopustular rosacea perifolliculitis capitis abscedens et suffodiens (dissecting cellulitis of the scalp, dissecting folliculitis, perifolliculitis capitis abscedens et suffodiens of Hoffman), perioral dermatitis, periorbital dermatitis (periocular dermatitis), pyoderma faciale (rosacea fulminans), rhinophyma, rosacea (acne rosacea), rosacea conglobata, rosacea fulminans, SAPHO syndrome, steroid rosacea, tropical acne.
- Acne vulgaris (commonly called acne) is a common skin condition, caused by changes in pilosebaceous units, skin structures consisting of a hair follicle and its associated sebaceous gland, via androgen stimulation. It is characterized by noninflammatory follicular papules or comedones and by inflammatory papules, pustules, and nodules in its more severe forms.
- Acne vulgaris affects the areas of skin with the densest population of sebaceous follicles; these areas include the face, the upper part of the chest, and the back. Severe acne is inflammatory, but acne can also manifest in noninflammatory forms. Acne lesions are commonly referred to as pimples, blemishes, spots, zits, or simply acne.
- acne is usually caused by an increase in male sex hormones, which people of both genders accrue during puberty. For most people, acne diminishes over time and tends to disappear - or at the very least decrease - after one reaches one's early twenties. There is, however, no way to predict how long it will take to disappear entirely, and some individuals will carry this condition well into their thirties, forties and beyond.
- the face and upper neck are the most commonly affected, but the chest, back and shoulders may have acne as well.
- the upper arms can also have acne, but lesions found there are often keratosis pilaris. Typical acne lesions are comedones, inflammatory papules, pustules and nodules. Some of the large nodules are also called cysts and the term nodulocystic has been used to describe severe cases of inflammatory acne.
- the treatment apparently works even better if used with a mixture of the violet/blue light and red visible light (e.g. 660 nm) resulting in a 76% reduction of lesions after three months of daily treatment for 80% of the patients; and overall clearance was similar or better than benzoyl peroxide. Unlike most of the other treatments few if any negative side effects are typically experienced, and the development of bacterial resistance to the treatment seems very unlikely. After treatment, clearance can be longer lived than is typical with topical or oral antibiotic treatments; several months is not uncommon. In addition, basic science and clinical work by dermatologists has produced evidence that intense blue/violet light (405 to 425 nm) can decrease the number of inflammatory acne lesion by 60 to 70% in four weeks of therapy, particularly when the P. acnes is pre-treated with delta-aminolevulinic acid (ALA), which increases the production of porphyrins.
- ALA delta-aminolevulinic acid
- the present invention therefore also relates to a combination of the said compositions and active drugs for the treatment of therapeutic diseases and/or cosmetic conditions.
- the present invention relates to the combined use of said compositions and drugs used for the treatment of acne.
- the drugs can be selected from any drugs typically employed in order to treat acne, such as antibiotics (topical and/or oral), hormonal treatments, topical retinoids, topical bactericidals, sulfur. Suitable topical bactericidals are, for example, benzoyl peroxide, triclosan, and
- Suitable topical antibiotics are, for example, erythromycin, clindamycin, and tetracycline.
- Suitable oral antibiotics are, for example, erythromycin, tetracycline antibiotics (e.g. oxytetracycline, doxycycline, minocycline, or lymecycline), trimethoprim, and minocycline.
- Suitable hormones are, e.g., selected from estrogen, progestogen, a combination of estrogen and progestogen, cyproterone, oestrogen, a combination of cyproterone and oestrogen, drospirenone, spironolactone, and cortisone.
- Suitable oral retinoids are, for example, vitamin A
- Suitable topical retinoids are, for example, tretinoin (e.g. Retin-A), adapalene (e.g. Differin), tazarotene (e.g. Tazorac), isotretinoin, and retinol.
- tretinoin e.g. Retin-A
- adapalene e.g. Differin
- tazarotene e.g. Tazorac
- isotretinoin retinol
- Further suitable drugs are , e.g. selected from anti- inflammatory drugs.
- compositions according to the present invention and devices comprising them can also be used in combination with dermabrasion to treat or prevent acne.
- Dermabrasion is a cosmetic medicinal procedure in which the surface of the skin is removed by abrasion (sanding).
- the drug e.g., can be administered first for a specific time period followed by the application of phototherapy using the compositions according to the present invention.
- the time gap between both treatments may also vary, depending on the drug, its photoreactivity, individual circumstances of the subject, and the specific disease or condition. Both treatments may also overlap timely either partly or completely.
- the exact treatment strategy will depend on the individual circumstances and the severity of the disease or condition.
- the combination therapy can have a synergistic effect and can reduce the side effects of traditional treatment strategies (e.g. the side effects of tetracyclines). This is due to the fact, that smaller doses of the drugs may be required when following the combined approach as outlined herein.
- Comedones can also be treated by phototherapy employing the compositions according to the present invention.
- a comedon is a yellow or blackish bump or plug on the skin. Actually, it is a type of acne vulgaris. Comedones are caused by excess oils that have accumulated in the sebaceous gland's duct. The substance found in these bumps mostly consists of keratin and modified sebum, which darkens as it oxidizes. Clogged hair follicles, where blackheads often occur, reflect light irregularly to produce a comedon. For this reason, the blockage might not necessarily look black when extracted from the pore, but may have a more yellow-brown colour as a result of its melanin content.
- whitehead which is also called closed comedo
- closed comedo is a follicle that is filled with the same material, sebum, but has a
- composition according to the present invention used for the treatment of acne preferably comprises at least one organic electroluminescent compound which emits light in the range between 350 and 900 nm, preferably between 380 and 850 nm, particularly preferably between 400 and 850 nm, and very particularly preferably between 400 and 800 nm.
- Preferred blue light has emission wavelengths for the treatment of acne are 390, 391 , 392, 393, 394, 395, 396, 397, 398, 399, 400, 401 , 402, 403, 404, 405, 406, 407, 408, 409, 410, 411 , 412, 413, 414, 415, 416, 417, 418, 419, 420, 421 , 422, 423, 424, 425, 426, 427, 428, 429 and 430 nm.
- 414 and 415 nm are particularly suitable in order to kill P. acnes bacteria and to help cure existing blemishes and to prevent further outbreaks.
- red light and blue light to treat acne.
- the said red light is preferably selected from the range between 590 to 750 nm, particularly preferably between 600 and 720 nm, and very particularly preferably between 620 and 700 nm.
- Two further preferred wavelengths for the treatment of acne are 633 and 660 nm.
- the blue light can be selected from the wavelengths as described above.
- a composition comprising organic light emitting compound(s) emitting light with a wavelength of 500 nm or light in the range between 500 and 700 nm are particularly preferred.
- Cellulite describes a condition that is claimed to occur in most women, where the skin of the lower limbs, abdomen, and pelvic region becomes dimpled.
- the causes of cellulite are poorly understood and may involve changes in metabolism and physiology such as gender specific dimorphic skin architecture, alteration of connective tissue structure, vascular changes and inflammatory processes.
- a couple of therapies are applied to prevent or to treat cellulite. Heat and the increase of blood flow are two common techniques. Therefore light therapy is considered to be beneficial to individuals suffering from cellulite.
- Compositions according to the present invention and devices comprising them are suitable for the treatment and/or prophylaxis of cellulite.
- PDT is also suitable for the treatment and/or prophylaxis of cellulite.
- the wavelength for the treatment and/or prophylaxis of cellulite that is to be emitted by the composition according to the present invention is in the range between 400 and 1000 nm, preferably in the range between 400 and 900 nm, particularly preferably between 450 and 900 nm, and very particularly preferably between 500 and 850 nm.
- skin ageing refers to both the formation of wrinkles and hyperpigmentation.
- the signs of ageing of the human skin resulting from the effects on the skin of intrinsic and extrinsic factors are defined by the appearance of wrinkles and fine lines, by the yellowing of the skin which develops a wizened appearance along with the
- Some of these signs are more particularly associated with intrinsic or physiological ageing, that is so to say with "normal” ageing associated with age, whereas others are more specific to extrinsic ageing, that is so to say ageing caused by the environment in general; such ageing is more particularly photo-ageing due to exposure to the sun.
- Other factors causing ageing of the skin are atmospheric pollution, wounds, infections, traumatisms, anoxia, cigarette smoke, hormonal status, neuropeptides, electromagnetic fields, gravity, lifestyle (e.g. excessive consumption of alcohol), repetitive facial expressions, sleeping positions, and
- This intrinsic ageing in particular causes slowing down of the regeneration of skin cells, which is reflected essentially in the appearance of clinical damage such as a reduction of the subcutaneous adipose tissue and the appearance of fine lines or small wrinkles, and in histopathological changes such as an increase in the number and thickness of the elastic fibers, a loss of vertical fibers from the elastic tissue membrane and the presence of large irregular fibroblasts in the cells of this elastic tissue.
- extrinsic ageing results in clinical damage such as thick wrinkles and the formation of flabby and weather-beaten skin, and in histopathological changes such as an excessive accumulation of elastic substance in the upper dermis and degeneration of the collagen fibers.
- Hydroxy acids such as lactic acid, glycolic or alternatively citric acid are also known for this same application, these acids having been described in numerous patents and publications (e.g. EP-A-413528) and introduced into numerous skin care, cosmetic, or dermatological compositions on the market.
- Aromatic orthohydroxy acids such as salicylic acid have also been proposed (e.g. WO 93/10756 and
- modulating the selectin function is a novel concept intervening the micro-inflammation cascade at a very early stage and treating and preventing intrinsic and extrinsic skin ageing according to the present inventions represents a strategy without the drawbacks known from other strategies.
- Phototherapy provides a new way to treat ageing of the skin.
- another subject of the invention is the use of the composition according to the present invention for the treatment and/or prophylaxis of skin ageing. This means, that the present invention provides solutions, inter alia, for skin rejuvenation and to reduce or prevent the formation of wrinkles.
- the wavelength for the treatment of skin ageing that is to be emitted by the composition according to the present invention is in the range between 400 and 950 nm.
- the wavelength is in the range between 550 and 900nm, and particularly preferably between 550 and 860 nm.
- compositions of the present invention may also emit light of different wavelengths or wavelength ranges which also applies for other embodiments of the present invention.
- the composition used for the treatment of skin ageing emits light in the range of 600 nm and 650 nm, particularly preferably in the range between 620 nm and 650 nm.
- the composition according to the present invention used for the treatment and/or prevention of skin ageing preferably comprises at least one organic electroluminescent compound which emits light in the range between 350 and 950 nm, preferably between 380 and 900 nm, and particularly preferably between 400 and 900 nm.
- Further particularly preferred light for the treatment and/or prophylaxis of skin ageing is blue light.
- Preferred blue light has emission wavelengths for the treatment and/or prophylaxis of skin ageing are 390, 391 , 392, 393, 394, 395, 396, 397, 398, 399, 400, 401 , 402, 403, 404, 405, 406, 407, 408, 409, 410, 411 , 412, 413, 414, 415, 416, 417, 418, 419, 420, 421 , 422, 423, 424, 425, 426, 427, 428, 429, and 430 nm.
- emission wavelengths for the treatment and/or prophylaxis of skin ageing are 390, 391 , 392, 393, 394, 395, 396, 397, 398, 399, 400, 401 , 402, 403, 404, 405, 406, 407, 408, 409, 410, 411 , 4
- 415 nm is particularly suitable.
- Further particular preferred light for the treatment and/or prophylaxis of skin ageing has a wavelength between 400 and 900 nm.
- compositions according to the present invention emitting light in the range between 700 nm and 1000 nm, preferably between 750 nm and 900 nm, particularly preferably between 750 nm and 860 nm, and very particularly preferably between 800 nm and 850 nm are also subject of the present invention.
- Redness of the skin of a subject can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of redness that is to be emitted by the composition according to the present invention is in the range between 460 and 660 nm.
- the wavelength is in the range between 500 and 620 nm, and particularly preferably between 540 and 580 nm.
- One particular preferred wavelength for this purpose is 560 nm.
- Dermatitis of a subject can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of dermatitis that is to be emitted by the composition according to the present invention is in the range between 470 and 670 nm.
- the wavelength is in the range between 490 and 650nm, and particularly preferably between 530 and 610 nm.
- wavelengths for this purpose are 550 nm and 590 nm.
- Atopic eczema of a subject can be treated by a composition according to the present invention.
- prophylaxis of atopic eczema that is to be emitted by the composition according to the present invention is in the range between 470 and 670 nm.
- the wavelength is in the range between 490 and 650nm, and particularly preferably between 530 and 610 nm.
- One particular preferred wavelength for this purpose is 320 nm.
- Psoriasis can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of psoriasis that is to be emitted by the composition according to the present invention is in the range between 240 and 500 nm.
- the wavelength is in the range between 290 and 400nm, and particularly preferably between 300 and 330 nm.
- wavelengths for this purpose are 311 and 320 nm.
- Vitiligo can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of vitiligo that is to be emitted by the composition according to the present invention is in the range between 240 and 500 nm.
- the wavelength is in the range between 290 and 400nm, and particularly preferably between 300 and 330 nm.
- One particular preferred wavelength for this purpose is 311 nm.
- Targeted phototherapy has enabled therapeutic dosing of ultraviolet light to specific dermatoses while minimizing exposure of healthy skin.
- the 308 nm wavelength of light within the ultraviolet B range has been shown as particularly effective for many dermatoses, including vitiligo; psoriasis; and leukoderma such as that associated with scars, striae alba and post-CO 2 laser resurfacing.
- the compositions of the present invention can also be used for the treatment of edema.
- Edema formerly known as dropsy or hydropsy, is an abnormal accumulation of fluid beneath the skin or in one or more cavities of the body. Generally, the amount of interstitial fluid is
- edema determined by the balance of fluid homeostasis, and increased secretion of fluid into the interstitium or impaired removal of this fluid may cause edema.
- composition according to the present invention used for the treatment of edema preferably comprises at least one organic electroluminescent compound which emits light in the range between 760 and 940 nm, preferably between 780 and 920 nm, particularly preferably between 800 and 900 nm, and very particularly preferably between 820 and 880 nm.
- One further particularly preferred emission wavelength for the treatment of edema is 850 nm.
- Another subject of the present invention relates to a composition according to the present invention for the treatment and/or prophylaxis of infections and inflammatory, neurological, and psychological diseases and/or conditions.
- a composition according to the present invention for the treatment and/or prophylaxis of inflammatory disorders is also subject of the present invention.
- Inflammatory diseases and conditions cover a wide range of indications.
- Many diseases or condition which are seemingly unrelated to inflammation have inflammatory components that can be treated with the compositions according to the present invention.
- the skin diseases and conditions mentioned in the present invention all have inflammatory components, such as acne, psoriasis, atopic dermatitis, eczema.
- a non limiting selection of further inflammatory diseases and conditions that can be treated with a composition according to the invention are arthritis, inflammatory bowel disease, gingival inflammation, inflammation of the mucosa, inflammation of the nail bed, arteriosclerosis, and inflammation of the vascular system.
- inflammation are in the range between 350 and 900 nm, particularly preferably between 380 and 900 nm, and very particularly preferably between 400 and 860 nm. Further preferred wavelengths for the treatment and/or prophylaxis of inflammation are 405, 420, and 850 nm.
- compositions can be used for the treatment and/or prophylaxis of infections.
- Infections can be caused by bacteria and viruses.
- Light has several positive effects on infections. Light has, e.g., anti-inflammatory effects through the stimulation of the tissue as outlined elsewhere within the present invention.
- Phototherapy with compositions according to the present invention are beneficial for the use to treat wounds. Wound healing is often associated with inflammation. Therefore the same wavelengths and ranges of wavelengths as outlined for the treatment and/or prophylaxis of inflammation can be applied. Treating wounds by phototherapy also prevents the formation of scares.
- wavelengths for the treatment and/or prophylaxis of wounds and/or scares are in the range between 600 and 950 nm and very particularly preferably between 650 and 900 nm. Further preferred wavelengths for the treatment and/or prophylaxis of wounds and scares are 660, 720, and 880 nm.
- compositions according to the present invention are caused by bacteria.
- compositions according to the present invention are caused by viruses.
- a preferred embodiment of this invention is the use of the said compositions and OLECs comprising them for the treatment and/or prophylaxis of viral infections particularly caused by cytomegalovirus (CMV), encephalo myocarditis virus (EMCV), poliovirus, influence virus, parainfluenza respiratory influenza virus, respiratory syncytial virus, Japanese
- CMV cytomegalovirus
- EMCV encephalo myocarditis virus
- poliovirus influence virus
- parainfluenza respiratory influenza virus respiratory syncytial virus
- HAV hepatitis A virus
- HBV hepatitis B virus
- HCV hepatitis C virus
- HDV hepatitis D virus
- HV hepatitis E virus
- HSV hepatitis F virus
- HGV hepatitis G virus
- EBV Epstein Barr Virus
- HMV-I human immunodeficiency virus type 1
- immunodeficiency virus type 2 HIV-2
- varicella zoster virus herpes simplex virus, in particular herpes simplex virus type 1 (HSV-I), herpes simplex virus type 2 (HSV-2), or human herpes virus 1 , 2, 3, 4, 7, or 8, Kaposi's sarcoma-associated herpesvirus (KSHV), rotavirus, papilloma virus, and human papilloma virus (HPV), in particular HPV of the types: 1 , 2, 3, 4, 5, 8, 9, 11 , 12, 13, 14, 15, 16, 17, 18, 19-29, 31 , 32, 34, 36-38, 46-50, 56, or 58.
- HSV-I herpes simplex virus type 1
- HSV-2 herpes simplex virus type 2
- HPV human papilloma virus
- HPV human papilloma virus
- compositions according to the present invention such as genital warts, benign tumors of the skin and/or mucosa caused by papilloma viruses, in particular verrucae plantares, verrucae vulgares, verrucae planae juveniles, epidermodysplasia verruciformis, Condylomata acuminate, Condylomata plana, bowenoid papulosis, papilloma on the larynx and oral mucosa, focal epithelial hyperplasia, herpes labialis, varicella and shingles.
- verrucae plantares verrucae vulgares
- verrucae planae juveniles verrucae planae juveniles
- epidermodysplasia verruciformis Condylomata acuminate
- Condylomata plana Condylomata plana
- bowenoid papulosis papilloma on the
- compositions of the invention can be used for the treatment and/or prophylaxis of warts.
- Pulsed light therapy might be one way to treat warts with compositions according to the present invention.
- a composition according to the present invention for the treatment and/or prophylaxis of neurological or psychological diseases and/or conditions is also subject of the present invention.
- a preferred neurological disease according to the present invention is
- Morbus Parkinson When light reaches a certain level of intensity, it inhibits melatonin which in turn limits the production of dopamine. By limiting the melatonin is supposed to lead to a have better production and use of dopamine in the brain.
- Recent case studies of light therapy on MB patients involving bright light therapy have had positive results with marked improvement in bradykinesia and rigidity in most patients while being exposed for only ninety minutes.
- Phototherapy can also be employed to treat depression, seasonal affective disorder (SAD), non seasonal depression, circadian rhythm sleep disorder (chronic circadian rhythm sleep disorder (CRSD), situational CRSD).
- SAD seasonal affective disorder
- CRSD chronic circadian rhythm sleep disorder
- situational CRSD situational CRSD
- the wavelength for the treatment and/or prophylaxis of these neurological and psychological diseases and/or conditions that is to be emitted by the composition according to the present invention is in the range between 350 and 600 nm.
- the wavelength is in the range between 400 and 550nm, and particularly preferably between 440 and 500 nm.
- Two particular preferred wavelengths for this purpose are 460 and 480 nm.
- the compositions according to the present invention may also be used for the treatment and/or prophylaxis of pain. Pain relief by phototherapy is well known.
- carpal tunnel syndrome chronic wounds, epicondylitis, headache, migraine, plantar fasciitis, tendonditis and bursitis, neck pain, back pain, muscle pain, trigeminal neuralgia, and Whiplash-associated injuries.
- muscle pain is treated with compositions emitting red or infrared light.
- Alopecia areata is a condition affecting humans, in which hair is lost from some or all areas of the body, usually from the scalp. Because it causes bald spots on the scalp, especially in the first stages, it is sometimes called spot baldness. In 1 to 2% of cases, the condition can spread to the entire scalp (alopecia totalis) or to the entire epidermis (alopecia universalis). Conditions resembling alopecia areata, and having a similar cause, occur also in other species. Alopecia areata (autoimmune hair loss) can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of alopecia areata that is to be emitted by the composition according to the present invention is in the range between 240 and 500 nm.
- the wavelength is in the range between 290 and 400 nm, and particularly preferably between 300 and 330 nm.
- One particular preferred wavelength for this purpose is 311 nm.
- a composition according to the present invention for the disinfection of beverages and nutrition is also subject of the present invention.
- compositions according to the present invention can be used for disinfection.
- any kind of disinfection is meant and includes without limitation the disinfection of wounds, nutrition, and solid and liquids objects, such cosmetic, medical devices, devices used for surgery and beverages.
- Preference is given to compositions for the disinfection of beverages, preferably water, and particularly preferably drinking water. Contaminated water causes many infections worldwide and leads often to severe diseases or death of the individuals.
- Compositions according to the present invention and OLECs comprising them provide a simple means to Water filter systems of commercial providers (e.g. BRITA water filter system) take advantage of ion exchange technology.
- the filter tend to microbial contamination, which, in turn results in water which is contaminated with microbes.
- One solution is to add silver salt which is from a toxicological point of view problematic.
- the compositions of the present invention provide a solution to this problem. They can be used in an OLEC to be incorporated into the water filter system in order to provide a safe, efficient, and low cost way to provide water with a low degree of microbial contamination.
- the light source can irradiate both the water before or after filtering or the filter cartridge itself.
- the light source comprising the compositions irradiates both the filter cartridge and the already filtered water.
- the procedure of disinfection of water as outlined above can basically be applied to any other liquid, in particular beverage analogously.
- compositions according to the present invention can be used for the disinfection of beverages and nutrition for humans and animals.
- Wavelengths for disinfection according to the present invention are in the range between 200 nm and 600 nm, preferably between 250 nm and 500 nm, and very particularly preferably between 280 nm and 450 nm.
- the present invention relates to the said
- Wavelengths required for PDT according to the present invention are in the range between 300 and 700 nm, preferably between 400 and 700 nm, and very particularly preferably between 500 and 700 nm.
- Four further preferred wavelengths are 595, 600, 630, and 660 nm.
- Any therapy known as PDT can be treated with compositions according to the present invention and devices comprising them.
- PDT as outlined within the present invention can be treated with compositions according to the present invention and devices comprising them.
- the property of dyes with a polycyclic hydrocarbon type chemical structure to accumulate in greater amounts in tumor tissues than in normal tissues is well known.
- the dyes include acridines, xanthenes, psoralens, and porphyrins.
- Hp hematoporphyrin
- Hp D hematoporphyrin
- Drug used for PDT are preferably selected from aminolevulinic
- porphyrin derivatives (porfimer sodium, talaporfin, temoporfin, verteporfin).
- the present invention relates to the said composition for the treatment and/or prophylaxis of jaundice and crigler naijar, preferably jaundice.
- Jaundice which is also known as icterus, is a yellowish discoloration of the skin, the conjunctival membranes over the sclerae (whites of the eyes), and other mucous membranes. The discoloration is caused by hyperbilirubinemia (increased levels of bilirubin in the blood). This hyperbilirubinemia subsequently causes increased levels of bilirubin in the extracellular fluids. Jaundice is classified in three groups, pre-hepatic (hemolytic) jaundice, hepatic (hepatocellular) jaundice, and post-hepatic (obstructive) jaundice.
- Pre-hepatic jaundice is caused by anything which causes an increased rate of hemolysis, i.e. breakdown of red blood cells. In tropical countries, malaria can cause jaundice in this manner. Certain genetic diseases, such as sickle cell anemia, spherocytosis and glucose 6-phosphate dehydrogenase deficiency can lead to increased red cell lysis and therefore hemolytic jaundice. Commonly, diseases of the kidney, such as hemolytic uremic syndrome, can also lead to coloration. Defects in bilirubin metabolism also present as jaundice. Jaundice usually comes with high fevers. Rat fever (leptospirosis) can also cause jaundice.
- Hepatic jaundice causes include acute hepatitis, hepatotoxicity and alcoholic liver disease, whereby cell necrosis reduces the liver's ability to metabolise and excrete bilirubin leading to a buildup in the blood. Less common causes include primary biliary cirrhosis, Gilbert's syndrome (a genetic disorder of bilirubin metabolism which can result in mild jaundice, which is found in about 5% of the population), Crigler-Najjar syndrome, metastatic carcinoma and Niemann-Pick disease, type C. Jaundice seen in the newborn, known as neonatal jaundice, is common, occurring in almost every newborn as hepatic machinery for the conjugation and excretion of bilirubin does not fully mature until approximately two weeks of age.
- Post-hepatic jaundice also called obstructive jaundice
- Post-hepatic jaundice is caused by an interruption to the drainage of bile in the biliary system.
- the most common causes are gallstones in the common bile duct, and pancreatic cancer in the head of the pancreas.
- a group of parasites known as "liver flukes" can live in the common bile duct, causing obstructive jaundice.
- Other causes include strictures of the common bile duct, biliary atresia, ductal carcinoma, pancreatitis and pancreatic pseudocysts.
- a rare cause of obstructive jaundice is Mirizzi's syndrome.
- Jaundice in particular neonatal jaundice, can lead to severe medical consequences if not or not appropriately treated. Increased
- compositions of the present invention can be employed in order to provide flexible and ambulatory devices such as blankets.
- Traditional therapies also easily lead to overheating of the infant, which can also be significantly reduced with the compositions of the present invention and devices comprising them.
- the present invention relates to compositions used for the treatment of neonatal jaundice. Jaundice of a subject can be treated by a composition according to the present invention.
- the wavelength for the treatment and/or prophylaxis of jaundice that is to be emitted by the composition according to the present invention is in the range between 300 and 700 nm.
- the wavelength is in the range between 350 and 600nm, and particularly preferably between 370 and 580 nm.
- Further preferred wavelengths are in the range between 400 and 550 nm. Particularly preferred wavelengths are in the range between 410 and 470 nm. Two particular preferred wavelengths for this purpose are 450 and 466 nm.
- the present invention also relates to a formulation comprising the said composition and at least one further solvent.
- the formulation comprises 3 solvents, particularly preferably 2 solvents and very particularly preferably 1 solvent.
- the solvent is an organic solvent.
- the solvent is selected from selected from cyclohexanone, acetonitrile, dichloromethane, trichloromethane, monochlorobenzene, toluene, chloroform, o-dichlorobenzene,
- the present invention relates to the use of the composition according to the invention for the preparation of a device for the treatment and or/prophylaxis of therapeutic diseases and/or cosmetic conditions.
- the therapeutic diseases and conditions are the same as the ones described elsewhere in the present invention.
- the device is an electroluminescent device.
- the present invention also relates to a device for the use in the treatment and/or prophylaxis of therapeutic diseases and/or cosmetic conditions, characterized in that the device comprises a said composition. Both the composition and the therapeutic and cosmetic conditions have already been described in detail above.
- the device can have any shape, be rigid or flexible.
- the device requires energy supply in any form. The energy supply may be directly associated to the device or separated by, e.g., a cable.
- a battery, particularly a printable battery may be attached to the device in order to provide a device which is comfortable for the subject to be treated forming a totally self-contained portable unit.
- Irradiation may, thus, occur at any time and at any place without disturbing the subject to be treated in its habits or daily life.
- Home use of devices according to the present invention is particularly preferable.
- the device may be self adhesive and detachable. It may conform a planar or non-planar portion of the body or be an implantable probe.
- the device may comprise an interactive steering unit.
- the steering unit may allow a switch from continuous illumination to pulsed illumination. It also may allow the precise adaptation of irradiation intensities and/or wavelengths to be emitted.
- the steering unit may be directly associated to the device. It can also be separated via a permanent or temporary linkage.
- the device may be disposable and is suitable for uses in the hospital or outside the hospital.
- the device according to the present invention is suitable as light weight device for portable use.
- stationary devices can also be prepared.
- the device is sufficiently portable to enable ambulatory treatment i.e. treatment in which the subject can move around freely. It can be subsequently removed in the human subject's own time, so that treatment could take place almost everywhere. This results in a better convenience and lower costs (from avoiding either an out-patient or inpatient stay in hospital).
- Ambulatory devices according to the present invention can be used with lower light levels since exposure can occur for a longer period of time. This overcomes a problem of pain induced in some patients by the high irradiances from conventional sources used in hospitals. In addition lower irradiance is more effective in PDT due to reduction of the extent of photobleaching of the photopharmaceutical.
- the devices may be provided with a photochemical and/or a
- photopharmaceutical preparation present. This may be in the form of a gel, ointment or cream. Alternatively, or as well, the device may be provided with a thin film impregnated with the photopharmaceutical.
- the photopharmaceutical preparation is provided as a layer in contact with the light source.
- the photopharmaceutical preparation is transparent or sufficiently translucent for the frequency of stimulating light, the resulting device can be readily applied without a separate step of applying the photopharmaceutical to a patient. Creams which would scatter the light may nevertheless be used if they are absorbed before the light source is switched on.
- a photopharmaceutical layer may be covered by a peelable release medium, such as a silicone- backed sheet.
- the photopharmaceutical preparation may comprise an inactive compound which is metabolised in vivo to an active compound. Delivery of the photopharmaceutical can be assisted by iontophoresis.
- the output of light from the organic light-emitting semiconductor may be pulsed and an electronic control circuit or microprocessor may be provided to control this pulsing and/or other aspects of device function such as duration of exposure(s) of the area to be treated and the intensity of emitted light.
- Pulsed devices may be provided with a preparation of a photochemical and/or a photopharmaceutical substance which is photobleachable or which is metabolised in vivo to a photobleachable chemical species.
- the output of the device may take the form of a train of pulses, preferably in which the duration of the pulses is substantially the same as the interval between successive pulses.
- the period of the pulse train may, for example, be in the range of 20 ms to 2000 s, depending on the
- the attachment means comprises an adhesive surface to enable the device to be attached to a patient.
- the ambulatory device is provided with a photochemical and/or a photopharmaceutical preparation present.
- a photochemical and/or a photopharmaceutical preparation present.
- Preferred features of the preparation and its delivery are as above.
- the photochemical and/or photopharmaceutical may be photobleachable or may be metabolised in vivo to a photobleachable chemical species.
- the means for activating and deactivating the source may control other aspects of device function such as duration of exposure(s) of the area to be treated and the intensity of emitted light.
- the control means may to advantage be operable to cover the source to emit a pulse train having any one or more of the preferred features of the pulse train produced by a device in accordance with the first aspect of the invention.
- Suitable devices according to the present invention are selected from sleeves, bandages, pads, plaster, implantable probes, nasogastric tubes, chest drains, stents, clothe like devices, blankets, sleeping bags, devices fitting one or more teeth in the mouth, and patches.
- the device may be used as a stent, for example a tube of 1.25 to 2.25 cm radius of say 10 to 12 cm length for use inside the oesophagus.
- the device may be a blanket or sleeping bag in order to treat, e.g., jaundice of infants.
- jaundice of infants.
- OLEDs OLEDs.
- the problem can, however, be solved with OLECs.
- OLECs can be designed to fit into body folds in order to treat psoriasis and other diseases and/or conditions found in body folds.
- Devices can generally spoken individually tailored in any form that is required for treatment.
- the device itself may comprise a therapeutic agent which is released in a controlled way during the treatment.
- the said device comprise a plastic ionic material as described above, which has a glass transition temperature T g or melting point in the range between 25 and 45°C.
- T g or melting point in the range between 25 and 45°C.
- the device will getting softer when attached to the skin in order to get a better contact to the skin.
- the device according to the present invention comprises an organic light emitting electrochemical cell (OLEC).
- OLECs are particularly suited for the application in phototherapy and PDT. They are rather simple in terms of structure and manufacturing, which reduces production costs. More advantages of OLECs have already been discussed within the present invention.
- the OLECs preferably comprise at least two electrodes, particularly preferably two electrodes, a cathode and an anode.
- Electrodes are connected through a composition according to the present invention.
- Preferred materials for the electrodes used in OLECs are selected from metals, particularly preferably selected from Al, Cu, Au, Ag, Mg, Fe, Co, Ni, Mn, Zn, Cr, V, Pd, Pt Ga, In and their alloys, conductive oxide, for example ITO, AZO, ZnO, and conductive organic thin films comprising such as poly(ethylenedioxythiophene)-polystyrene sulfonate
- PEDOT:PSSH Polyaniline
- PANI Polyaniline
- the OLECs are prepared on a flexible substrate.
- the suitable substrate is preferably selected from films or foils based on polymers or plastics.
- the main selection criteria for polymers or plastics are 1) hygienic property and 2) glass transition temperature.
- T g temperature of the polymers
- T g temperature of the polymers
- the T g of the polymer is above 100°C, particularly preferably above 150°C, and very particularly preferably above 180°C.
- Very preferred substrates are for example, poly(ethylene terephthalate) (PET) and poly(ethylene 2,6- naphthalate) (PEN).
- an appropriate encapsulation for the said device is a prerequisite for the applications in therapeutic treatments and cosmetic conditions.
- the device of the present invention is encapsulated using a thin film encapsulation.
- a thin film encapsulation consists of a multi alternating layers of an inorganic/organic stack, wherein inorganic layers are used to achieve adequate barrier performance and organic layers to eliminate inevitable defects of the inorganic layers.
- the materials used for inorganic layers can be selected from metals, metal oxides or mixed oxides, for example Ag, SiO x , SiN x , ⁇ , ZrO x , ⁇ , HfO x , TiO x and indium tin oxide and so on.
- Some examples are alternating multilayers of vacuum-deposited acrylate polymers/ ⁇ as reported by Graff, G. L. et al. (J. Appl. Phys.
- PAPLD plasma assisted pulsed laser deposition
- PECVD plasma enhanced chemical vapor deposition
- the device of the present invention is encapsulated by using a curable resin together with a cap, wherein the cap covers at least the light emitting area, and the curable resin is applied between the substrate and the cap.
- the cap materials can be selected from metals and plastics in form of a plate or foil, and glass cap.
- the cap is flexible, which is preferably selected from metal foils, plastic foils or metallised plastic foils.
- the metal can be selected from Al, Cu, Fe, Ag, Au Ni, whereby Al is particularly preferred.
- the selection criteria for plastics are 1) hygienic aspects 2) the glass transition temperature (T g ), which is supposed to be high enough. T g of polymers can be found in a suitable handbook, for example in "Polymer Handbook", Eds. J. Brandrup, E. H. Immergut, and E. A. Grulke, John Willey & Sons, Inc., 1999, VI/193-VI/276.
- the polymer suitable for cap material has a T g above 60°C, preferably above 70°C, particularly preferably above 100°C, and very particularly preferably above 120°C.
- the cap used in the present invention is poly(ethylene 2,6-naphthalate) (PEN).
- PEN poly(ethylene 2,6-naphthalate)
- the suitable resin can be thermally cured or UV-curable.
- the resin is UV-curable, optionally supported or facilitated by heating.
- a typical resin is the epoxy-based resin, which is commercially available at for example Nagase & Co., LTD. and DELO Industrie Klebstoffe.
- the resin can be applied on full-area of the emitting area or just on the edge, where no light emitting area is underneath.
- Preferred electrode materials can selected from all metals, preferably Al, Cu, Au, Ag, Mg, Fe, Co, Ni, Mn, Zn, Cr, V, Pd, Pt and their alloys, conductive oxide, for example ITO, AZO, ZnO etc., and conductive organic thin films comprising PEDOT:PSSH, PANi etc.
- the OLECs are prepared on a flexible substrate.
- the suitable substrate is preferably selected from films or foils based on polymers or plastics.
- the selection criterion for polymers or plastics are 1) hygienic property 2) glass transition temperature.
- the glass temperature (Tg) of the polymers can be found in a suitable handbook, for example in
- the Tg of the polymer is above 100°C, very preferably above 150°C, and particularly above 180°C.
- Very preferred substrates are for example, poly(ethylene terephthalate) (PET) and poly(ethylene 2,6-naphthalate) (PEN)
- the said composition further comprises an ion conductor, which is preferably selected from polymeric materials, such as perfluorosulfonic acid-based formulations, polybenzimidazoles, sulfonated polyetherketone, sulfonated naphthalenic polyimides, and polyethylene oxide (PEO)-based formulations.
- an ion conductor which is preferably selected from polymeric materials, such as perfluorosulfonic acid-based formulations, polybenzimidazoles, sulfonated polyetherketone, sulfonated naphthalenic polyimides, and polyethylene oxide (PEO)-based formulations.
- PEO polyethylene oxide
- the device according to the present invention emits electromagnetic radiation to cause said treatment and/or prophylaxis of the area, wherein the OLEC has an extent of at least 0.5 cm 2 .
- the OLEC can be continuous or discontinuous.
- the OLEC and its illuminating area can adopt any shape that is suitable for the treatment. This can, in particular in therapeutic conditions, prevent side effects through the irradiation of parts of the subject whose treatment is not required.
- the device of the present invention has an extent between 0.5 cm 2 and 100000 cm 2 , particularly preferably between 0.5 cm 2 and 50000 cm 2 .
- the device according to the present invention is an ambulatory device.
- the present invention also relates to a device, characterized in that it comprises an attachment means for attaching the device to a patient.
- the device can be self adhesive or can be temporarily fixed at the side of action with an auxiliary material such as a glue strip.
- the said device is characterized in that it can be a plaster, bandage, blanket, sleeping bag, sleeve, implantable probe, nasogastric tube, chest drain, pad, stent, and patch.
- the form and shape of the device can be tailored according to the individual needs of the treatment and according to the constitution of the subject to be treated.
- the present invention also relates to a device according to this invention, characterized in that the device comprises a power supply unit.
- the power supply can be a directly attached to the device. This allows the design of ultra-thin devices which, e.g., can be used under the clothes without disturbing the subject to be treated.
- the power supply can also be in a more separated unit which is connected to the device in any possible way in order to supply the power.
- the device according to the present invention is intended to illuminate parts of the subject.
- a device characterized in that the device is used in the treatment and/or prophylaxis therapeutic and/or cosmetic diseases and conditions in animals and humans.
- compositions or a device according to this invention for the treatment and/or prophylaxis of therapeutic diseases.
- the therapeutic diseases are the same as outlined above.
- compositions or a device according to the present invention for the treatment and/or prophylaxis of cosmetic conditions is also subject of the present invention.
- the cosmetic conditions are the same as outlined above.
- the present invention relates to a method for the treatment and/or prophylaxis of diseases of humans and/or animals by using the compositions according to the present invention.
- the present invention also relates to a method for the treatment and/or prophylaxis of cosmetic conditions of humans and/or animals by using the compositions according to the present invention.
- the said methods can be used to treat the skin and other parts of the human or animal body as outlined above.
- the present invention relates to a method for the treatment and/or prophylaxis of diseases of humans and/or animals by using devices comprising the said compositions to irradiate parts of the body of humans and/or animals, preferably the skin.
- the present invention relates to a method for the treatment and/or prophylaxis of cosmetic conditions of humans and/or animals by using devices comprising the said compositions to irradiate parts of the body of humans and/or animals, preferably the skin.
- compositions, devices, (therapeutic) diseases, cosmetic conditions etc. are the same as defined elsewhere within the present application. It will be appreciated that variations to the foregoing embodiments of the invention can be made while still falling within the scope of the invention.
- Each feature disclosed in this specification, unless stated otherwise, may be replaced by alternative features serving the same, equivalent or similar purpose. Thus, unless stated otherwise, each feature disclosed is one example only of a generic series of equivalent or similar features.
- the following polymers IL1 , BE1 , and RE2 are synthesized by employing the Suzuki coupling.
- the reaction can be carried out according to synthetic methods well known to the person skilled in the art. The method is described, e.g., in WO 2003/048225.
- Polymer IL1 used as interlayer, is the copolymer comprising the following monomers with mol% as indicated:
- the molecular weight (MW) of the resulting polymer IL1 is distributed between 200000 to 300000 g/mol.
- BE1 is a copolymer of 50% phenanthrene and 50% spiro-bifluorene, which emits light in the deep blue region from 380 to 500 nm, with a maximum close to 420 nm.
- MW molecular weight
- YE1 Super Yellow, PDY-132, available from Merck KGaA, Germany
- PPV poly(para-phenylene vinylene)
- RE1 is an ionic transition-metal complex Ru(bpy) 3 2+ (PF 6 ⁇ )2 as shown bellow with PF 6 " as counterion.
- RE1 has a broad emission from 560 to 800 nm with a peak around 630 nm.
- the synthesis of RE1 is as follows: Ru(bpy)3CI 2 is purchased from Alfa and is used as received.
- RE1 is obtained by counterion exchange to PF 6 " via a metathesis reaction in which RE1 is precipitated from aqueous solutions of the corresponding CI salts and an excess of NH 4 PF 6 , washed with water, and dried.
- RE2 is conjugated copolymer containing Iridium metal complex on main chain having a molecular weight (MW) of about 300000 to 500000 g/mol.
- PMMA Poly(methyl methacrylate)
- PEO Poly(ethylene oxide)
- IM1 The salt KCF 3 SO 3 (IM1) and tetrabutylammonium tetracyanoborate (IM2) are two ionic materials (IMs).
- IM1 is purchased from Alfa Aesar, and is used as received.
- the synthesis of IM2 can be referred to Z. Anorg. Allg. Chem. 2000, 626, 560-568.
- Formulation 1 is then prepared by mixing solutionla and solutionlb in a desired ratio so that the mass ratio of BE1 :PEO:IM2 is 1 :1 :0.2. b) Preparation of Formulation 2
- Formulation 2 is then prepared by mixing solution2a and solution2b in a desired ratio so that the mass ratio of YE1 :PEO:IM1 is
- concentration is 10 mg/ml
- Formulation 4 is then prepared by mixing solution4a and solution4b in a desired ratio so that the mass ratio of RE2:PEO:IM1 is 1 :1:0.2.
- the Formulations can be used to prepare thin films, as required for the devices according to the present invention.
- the solid powder of the compositions can also be obtained by evaporating the solvents of the above prepared solutions.
- the flexible poly(ethylene naphthalate) (PEN) is used as substrate for OLECs
- PEN poly(ethylene naphthalate)
- 150 nm ITO is sputtered on PEN using a mask, as shown in Figure 3. It will be referred hereafter to as Sub1.
- Sub1 has a dimension of 3x3 cm, and a OLEC pixel of 2x2 cm.
- OLEC1 using BE1 in the emissive layer, in a sandwiched structure as shown in Figure 2a is prepared according to the following steps:
- PDEOT (Baytron P Al 4083) is deposited with a thickness of 80 nm onto Sub1 by spin coating and then heated for 10 min. at 120°C;
- the emissive layer is deposited by spin-coating Formulation 1
- the device is encapsulated according to the method as described in
- step 1.) see step 1.) for the preparation of OLEC1 ;
- step 2.) see step 2.) for the preparation of OLEC1 ;
- step 3.) see step 3.) for the preparation of OLEC 1 ;
- step 4. see step 4.) for the preparation of OLEC 1 ;
- OLEC1 and OLEC2 are analyzed according to methods well known to one skilled person. Electroluminescent spectrums are recorded. At a voltage of 6 V, both OLECs shows bright blue electroluminescent emission. The electroluminescent spectrum of OLEC1 after applied 6 V for 5 min. is shown in Figure 6, showing a broad blue emission between 400 and 500 nm. OLEC2 has a similar electroluminescent spectrum as compared to OLEC1 The stability is tested under constant driving voltage. OLEC1 operates for 30 min.. The interlayer in OLEC2 significantly improves operating time of the device. OLEC2 operates for at least 6 hrs.. Example 5
- OLEC3 using RE1 in the emissive layer, in a sandwiched structure as shown in Figure 2a is prepared in analogy to the preparation of OLEC1.
- step 2 of the preparation procedure of OLEC3 Formulation 3 is used instead of Formulation 1.
- OLEC4 using RE1 in the emissive layer, in a planar structure as shown in Figure 4, is prepared in the following steps: . ) Emissive layer is deposited by spin-coating Formulation 3 on
- substrate Sub2 yielding a layer with a thickness of 200 to 300 nm in glove-box;
- the device is encapsulated according to the method as described in
- OLEC3 and OLEC4 are analyzed according to methods well known to one skilled person. At 4 V, OLEC3 shows bright red electroluminescent emission. In OLEC4, light emission comes from the area near to the negative electrodes fingers after applied 10 V after 2 min.. The stability is tested under constant driving voltage. OLEC3 works for more than 7hrs at 4 V. OLEC4 still works at 12V for at least one day.
- OLEC5 using RE2 in the emissive layer, in a sandwiched structure as shown in Figure 2a is prepared in analogy to the preparation of OLEC1.
- step 2 of the preparation procedure of OLEC5 Formulation 4 is used instead of Formulation 1.
- OLEC6 using RE2 in the emissive layer, in a planar structure as shown in Figure 4 is prepared in analogy to the preparation of OLEC4. However, in step 1 of the preparation procedure of OLEC6 Formulation 4 is used instead of Formulation 3.
- the OLEC5 and OLEC6 are investigated according to methods well known to one skilled person. Electroluminescent spectrums are recorded.
- OLEC5 shows bright red electroluminescent emission.
- Figure 7 depicts the electroluminescent spectrum of OLEC5 at 4 V after 5 min..
- Figure 7 shows a broad red emission from 580 to 750 nm.
- light emission comes from the area near to the negative electrodes fingers after having applied 9 V for 2 min..
- the stability is investigated under constant driving voltage.
- OLEC5 works for more than 4 days at 4 V.
- OLEC6 works at 9 V for at least 4 days.
- OLEC7 using YE1 in the emissive layer, in a sandwiched structure as shown in Figure 2a is prepared in analogy to the preparation of OLEC1.
- step 2 of the preparation procedure of OLEC7 Formulation 2 is used instead of Formulation 1.
- OLEC8 using YE1 in the emissive layer, in a planar structure as shown in Figure 4, is prepared in analogy to the preparation of OLEC4. However, in step 1 of the preparation procedure of OLEC8 Formulation 2 is used instead of Formulation 3.
- OLEC7 and OLEC8 are investigated according to methods well known to one skilled person. Electroluminescent spectrums are recorded. At 3.5V, OLEC7 shows bright red electroluminescent emission. Figure 8 shows the electroluminescent spectrum of OLEC7 at 3.5 V after 5 min..
- Figure 8 shows a broad blue emission from 500 to 700 nm with a maximal peak close to 590 nm.
- light emission comes from the area near to the negative electrodes fingers at 8 V after 2 min..
- the stability is investigated under constant driving voltage.
- OLEC7 works for at least 5 days at 4 V.
- OLEC8 works for at least 5 days at 8 V.
- Encapsulation of OLEC1 to OLEC8 is achieved using a UV-cured resin, UV Resin T-470/UR7114 (Nagase Chemtex Corporation), and a PEN cap, which is smaller than the substrate to leave the contact pads free, as shown in step 4 of Figure 3.
- UV-resin is applied at first on the edge of the pixel, and the cap is then located on top of them. Then the device is exposed to UV light for 30 seconds. All theses are done in glove-box.
- the final devices for using in therapeutic and cosmetic applications can be realised, e.g., by attaching the OLECs devices to plasters, as shown in Figure 3.
- the external power source can be applied through the contact pads.
- a battery is a preferred power source for the devices, particularly preferred is the printed thin film battery for light weight.
- the printed thin film battery can be acquired, for example from Fraunhofer Institute, as shown in Figure 9.
- the device should be driven in pulse mode.
- OLECs can be increased when operated in a pulse voltage scheme. Therefore a controller, particularly a pocket portable one, for pulse driving, is desired. This can be realised by using a commercially available flasher unit or blinker unit. Further such flasher unit can be integrated in the power unit, according to the principle of general trigger circuit, as for example shown in suction Elektrotechnik, Verlag Europa-Lehrstoff, Nourney, Vollmer GmbH & Co., 5657 Haan-Gruiten, 227.
- OLEC7 comprising YE1 in the emissive layer can be used for the treatment and/or prophylaxis of wrinkles.
- the device is encapsulated according to the procedure in Example 8.
- a plaster is prepared according to Example 9 having a printed battery as power supply. The battery on each plaster supplies energy for a irradiation time of 30 min..
- a 20-week pilot study with 18 female human subjects in the age between 30 and 40 years is conducted according to standard methods well known to the person skilled in the art.
- One of the main selection criteria for the inclusion within the study is the occurrence of crown's feet with almost equal manifestation on both sides of the face, i.e. in proximity to the left and right eye.
- Each subject is treated on the right hand side with a plaster comprising OLEC7 for 30 min. every second day for 20 weeks.
- the first plaster comprises OLEC1 emitting blue light
- the second one comprises OLEC5 emitting red light.
- the plaster comprising the OLEC has squared shape with 9 cm 2 , but any other customized shape is possible.
- a 3-week pilot study with 26 subjects is conducted according to standard methods well known to the person skilled in the art.
- the subjects have Fitzpatrick skin types II to IV with mild to severe symmetric facial acne vulgaris.
- the right half of the forehead is treated with two different plasters in an alternating way.
- Overall 8 treatments are carried out.
- the first treatment is done by employing a first plaster emitting blue light (OLEC1) for 20 min..
- OLEC5 Three days later the same skin is treated with a second plaster emitting red light (OLEC5) for 30 min. Further three days later the same skin is again treated with a first plaster, and so on.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Materials Engineering (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Electroluminescent Light Sources (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/514,879 US20120245658A1 (en) | 2009-12-09 | 2010-11-11 | Therapeutic and Cosmetic Electroluminescent Compositions |
ES10776951.5T ES2620474T3 (es) | 2009-12-09 | 2010-11-11 | Composiciones electroluminiscentes terapéuticas y cosméticas |
KR1020127017724A KR101840481B1 (ko) | 2009-12-09 | 2010-11-11 | 치료적 및 미용적 전계발광 조성물 |
JP2012542381A JP6250283B2 (ja) | 2009-12-09 | 2010-11-11 | 治療用及び美容用エレクトロルミネセント組成物 |
EP10776951.5A EP2510072B1 (en) | 2009-12-09 | 2010-11-11 | Therapeutic and cosmetic electroluminescent compositions |
US14/146,270 US20140148877A1 (en) | 2009-12-09 | 2014-01-02 | Therapeutic and cosmetic electroluminescent compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09015222 | 2009-12-09 | ||
EP09015222.4 | 2009-12-09 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/514,879 A-371-Of-International US20120245658A1 (en) | 2009-12-09 | 2010-11-11 | Therapeutic and Cosmetic Electroluminescent Compositions |
US14/146,270 Division US20140148877A1 (en) | 2009-12-09 | 2014-01-02 | Therapeutic and cosmetic electroluminescent compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011069590A1 true WO2011069590A1 (en) | 2011-06-16 |
Family
ID=43415194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/006874 WO2011069590A1 (en) | 2009-12-09 | 2010-11-11 | Therapeutic and cosmetic electroluminescent compositions |
Country Status (7)
Country | Link |
---|---|
US (2) | US20120245658A1 (ja) |
EP (1) | EP2510072B1 (ja) |
JP (1) | JP6250283B2 (ja) |
KR (1) | KR101840481B1 (ja) |
ES (1) | ES2620474T3 (ja) |
PL (1) | PL2510072T3 (ja) |
WO (1) | WO2011069590A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013056110A1 (en) * | 2011-10-14 | 2013-04-18 | Nitto Denko Corporation | Light-emitting devices for wound healing |
WO2013113349A1 (en) | 2012-01-30 | 2013-08-08 | Merck Patent Gmbh | Nanocrystals on fibers |
EP2675524A1 (en) * | 2011-02-14 | 2013-12-25 | Merck Patent GmbH | Device and method for treatment of cells and cell tissue |
JP2014508817A (ja) * | 2010-12-23 | 2014-04-10 | メルク パテント ゲーエムベーハー | 有機エレクトロルミネッセンス素子 |
WO2014082705A1 (de) | 2012-11-30 | 2014-06-05 | Merck Patent Gmbh | Elektronische vorrichtung |
WO2014106520A1 (de) * | 2013-01-03 | 2014-07-10 | Merck Patent Gmbh | Uv-emitter mit mehrfachbindung |
JP2015520166A (ja) * | 2012-05-24 | 2015-07-16 | メルク パテント ゲーエムベーハー | 縮合複素環式芳香族環を含む金属錯体 |
TWI670098B (zh) * | 2011-10-14 | 2019-09-01 | 日商日東電工股份有限公司 | 用於創傷癒合之發光裝置、光療系統及發光裝置與光療系統之用途 |
CN113750372A (zh) * | 2021-09-02 | 2021-12-07 | 北京翌光医疗科技研究院有限公司 | 一种柔性面罩 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2606491A4 (en) | 2010-08-20 | 2015-08-26 | Rhodia Operations | FOILS WITH ELECTRICALLY CONDUCTIVE POLYMERS |
DE102011011104A1 (de) * | 2011-02-12 | 2012-08-16 | Merck Patent Gmbh | Substituierte Dibenzonaphtacene |
KR20140018548A (ko) * | 2012-08-02 | 2014-02-13 | 삼성디스플레이 주식회사 | 광효율이 향상된 유기발광 표시장치 및 그 제조방법 |
KR101970361B1 (ko) * | 2012-08-20 | 2019-04-19 | 삼성디스플레이 주식회사 | 유기 발광 표시 장치 및 이의 제조방법 |
DE102013013876A1 (de) * | 2013-08-20 | 2015-03-12 | Merck Patent Gmbh | Metallkomplexe |
KR20240005971A (ko) * | 2013-12-06 | 2024-01-12 | 메르크 파텐트 게엠베하 | 화합물 및 유기 전자 소자 |
KR102112638B1 (ko) | 2014-02-07 | 2020-05-19 | 삼성디스플레이 주식회사 | 표시 장치 |
WO2015149911A1 (en) | 2014-03-31 | 2015-10-08 | Merck Patent Gmbh | White light emission |
JP6673214B2 (ja) * | 2014-11-13 | 2020-03-25 | コニカミノルタ株式会社 | 有機エレクトロルミネッセンス治療装置 |
DE102015101688B4 (de) * | 2015-02-05 | 2022-12-15 | Pictiva Displays International Limited | Organische Leuchtdiodenvorrichtung |
WO2017120672A1 (en) | 2016-01-11 | 2017-07-20 | Klox Technologies Limited | Biophotonic compositions for the treatment of pyoderma |
WO2018198052A1 (en) | 2017-04-26 | 2018-11-01 | Oti Lumionics Inc. | Method for patterning a coating on a surface and device including a patterned coating |
US20220118276A1 (en) * | 2017-05-30 | 2022-04-21 | Tcellerate Llc | Device for photo-therapy and use thereof |
US11751415B2 (en) | 2018-02-02 | 2023-09-05 | Oti Lumionics Inc. | Materials for forming a nucleation-inhibiting coating and devices incorporating same |
JP7220964B2 (ja) * | 2018-10-26 | 2023-02-13 | 株式会社日本触媒 | 光美容又は光治療用有機電界発光シート |
JP7390739B2 (ja) | 2019-03-07 | 2023-12-04 | オーティーアイ ルミオニクス インコーポレーテッド | 核生成抑制コーティングを形成するための材料およびそれを組み込んだデバイス |
WO2020212325A1 (en) * | 2019-04-15 | 2020-10-22 | Signify Holding B.V. | Cytochrome c oxidase activating lighting system for mitochondrial activation and ocular health |
CN114072705A (zh) | 2019-05-08 | 2022-02-18 | Oti照明公司 | 用于形成成核抑制涂层的材料和结合所述成核抑制涂层的装置 |
CA3240373A1 (en) | 2020-12-07 | 2022-06-16 | Michael HELANDER | Patterning a conductive deposited layer using a nucleation inhibiting coating and an underlying metallic coating |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1782857A2 (en) * | 2001-11-17 | 2007-05-09 | The University Court of the University of St. Andrews | Therapeutic light emitting device |
US20080096028A1 (en) * | 2004-07-21 | 2008-04-24 | Koninklijke Philips Electronics, N.V. | Light-Emitting Electrochemical Cell |
US20080157662A1 (en) * | 2006-06-20 | 2008-07-03 | Lonergan Mark C | Heteroionic junction light emitting electrochemical cell |
WO2010085180A1 (en) * | 2009-01-21 | 2010-07-29 | Ludvig Edman | Light-emitting electrochemical cell and system. use thereof and method for their operation |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3798492A (en) * | 1971-05-17 | 1974-03-19 | Itt | Emissive electrode |
WO1997033323A1 (en) * | 1996-03-04 | 1997-09-12 | Uniax Corporation | Polyfluorenes as materials for photoluminescence and electroluminescence |
US6096066A (en) * | 1998-09-11 | 2000-08-01 | Light Sciences Limited Partnership | Conformal patch for administering light therapy to subcutaneous tumors |
US6821645B2 (en) * | 1999-12-27 | 2004-11-23 | Fuji Photo Film Co., Ltd. | Light-emitting material comprising orthometalated iridium complex, light-emitting device, high efficiency red light-emitting device, and novel iridium complex |
US6723828B2 (en) * | 2001-05-23 | 2004-04-20 | Sri International | Conjugated electroluminescent polymers and associated methods of preparation and use |
US7320845B2 (en) * | 2002-05-24 | 2008-01-22 | The Intertech Group, Inc. | Printed battery |
US6866678B2 (en) * | 2002-12-10 | 2005-03-15 | Interbational Technology Center | Phototherapeutic treatment methods and apparatus |
JP2004358063A (ja) * | 2003-06-06 | 2004-12-24 | Seiko Epson Corp | 治療用被着体 |
US20040262577A1 (en) * | 2003-06-26 | 2004-12-30 | Fuji Photo Film Co., Ltd. | Phosphor, producing method thereof, and electroluminescence device containing the same |
US7670506B1 (en) * | 2004-12-30 | 2010-03-02 | E. I. Du Pont De Nemours And Company | Photoactive compositions for liquid deposition |
US8029927B2 (en) * | 2005-03-22 | 2011-10-04 | Blue Spark Technologies, Inc. | Thin printable electrochemical cell utilizing a “picture frame” and methods of making the same |
US20060217787A1 (en) * | 2005-03-23 | 2006-09-28 | Eastman Kodak Company | Light therapy device |
WO2009099707A1 (en) * | 2008-02-05 | 2009-08-13 | Crain, John, M. | Printed electronics |
JP5913804B2 (ja) * | 2008-08-22 | 2016-04-27 | 日宝化学株式会社 | イオン性化合物及びその製造方法、並びに、これを用いたイオン伝導性材料 |
WO2010044879A2 (en) * | 2008-10-16 | 2010-04-22 | Carl Frederick Edman | Method and devices for self adjusting phototherapeutic intervention |
US20100179469A1 (en) * | 2009-01-05 | 2010-07-15 | Plextronics, Inc. | Organic Light Emitting Diode Phototherapy Lighting System |
US8212473B2 (en) * | 2009-04-22 | 2012-07-03 | Simon Fraser University | Flexible polymeric light emitting/charge storage device and system |
US20110057151A1 (en) * | 2009-09-10 | 2011-03-10 | Add-Vision, Inc. | Ionic salt combinations in polymer electroluminescent inks |
-
2010
- 2010-11-11 US US13/514,879 patent/US20120245658A1/en not_active Abandoned
- 2010-11-11 PL PL10776951T patent/PL2510072T3/pl unknown
- 2010-11-11 WO PCT/EP2010/006874 patent/WO2011069590A1/en active Application Filing
- 2010-11-11 JP JP2012542381A patent/JP6250283B2/ja not_active Expired - Fee Related
- 2010-11-11 KR KR1020127017724A patent/KR101840481B1/ko active IP Right Grant
- 2010-11-11 ES ES10776951.5T patent/ES2620474T3/es active Active
- 2010-11-11 EP EP10776951.5A patent/EP2510072B1/en not_active Not-in-force
-
2014
- 2014-01-02 US US14/146,270 patent/US20140148877A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1782857A2 (en) * | 2001-11-17 | 2007-05-09 | The University Court of the University of St. Andrews | Therapeutic light emitting device |
US20080096028A1 (en) * | 2004-07-21 | 2008-04-24 | Koninklijke Philips Electronics, N.V. | Light-Emitting Electrochemical Cell |
US20080157662A1 (en) * | 2006-06-20 | 2008-07-03 | Lonergan Mark C | Heteroionic junction light emitting electrochemical cell |
WO2010085180A1 (en) * | 2009-01-21 | 2010-07-29 | Ludvig Edman | Light-emitting electrochemical cell and system. use thereof and method for their operation |
Non-Patent Citations (1)
Title |
---|
D.A. BERNARDS, S. FLORES-TORRES, H. D. ABRUNA, G. G. MALLIARAS: "Observation of electroluminescence and photovoltaic response in ionic junctions", SCIENCE, vol. 313, 2006, pages 1416 - 1419, XP002616514 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014508817A (ja) * | 2010-12-23 | 2014-04-10 | メルク パテント ゲーエムベーハー | 有機エレクトロルミネッセンス素子 |
EP2675524B1 (en) * | 2011-02-14 | 2017-05-10 | Merck Patent GmbH | Device and method for treatment of cells and cell tissue |
US9492681B2 (en) | 2011-02-14 | 2016-11-15 | Merck Patent Gmbh | Device and method for treatment of cells and cell tissue |
EP2675524A1 (en) * | 2011-02-14 | 2013-12-25 | Merck Patent GmbH | Device and method for treatment of cells and cell tissue |
TWI670098B (zh) * | 2011-10-14 | 2019-09-01 | 日商日東電工股份有限公司 | 用於創傷癒合之發光裝置、光療系統及發光裝置與光療系統之用途 |
WO2013056110A1 (en) * | 2011-10-14 | 2013-04-18 | Nitto Denko Corporation | Light-emitting devices for wound healing |
US10786683B2 (en) | 2011-10-14 | 2020-09-29 | Nitto Denko Corporation | Light-emitting devices for wound healing |
WO2013113349A1 (en) | 2012-01-30 | 2013-08-08 | Merck Patent Gmbh | Nanocrystals on fibers |
JP2015520166A (ja) * | 2012-05-24 | 2015-07-16 | メルク パテント ゲーエムベーハー | 縮合複素環式芳香族環を含む金属錯体 |
US9879177B2 (en) | 2012-05-24 | 2018-01-30 | Merck Patent Gmbh | Metal complexes comprising condensed heteroaromatic rings |
WO2014082705A1 (de) | 2012-11-30 | 2014-06-05 | Merck Patent Gmbh | Elektronische vorrichtung |
WO2014106520A1 (de) * | 2013-01-03 | 2014-07-10 | Merck Patent Gmbh | Uv-emitter mit mehrfachbindung |
JP2016505216A (ja) * | 2013-01-03 | 2016-02-18 | メルク パテント ゲーエムベーハー | 多重結合を含む紫外発光体 |
CN113750372A (zh) * | 2021-09-02 | 2021-12-07 | 北京翌光医疗科技研究院有限公司 | 一种柔性面罩 |
CN113750372B (zh) * | 2021-09-02 | 2024-06-11 | 北京翌光医疗科技研究院有限公司 | 一种柔性面罩 |
Also Published As
Publication number | Publication date |
---|---|
JP2013513555A (ja) | 2013-04-22 |
KR101840481B1 (ko) | 2018-03-20 |
KR20120105024A (ko) | 2012-09-24 |
US20120245658A1 (en) | 2012-09-27 |
EP2510072A1 (en) | 2012-10-17 |
JP6250283B2 (ja) | 2017-12-20 |
EP2510072B1 (en) | 2016-12-21 |
PL2510072T3 (pl) | 2017-07-31 |
ES2620474T3 (es) | 2017-06-28 |
US20140148877A1 (en) | 2014-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2510072B1 (en) | Therapeutic and cosmetic electroluminescent compositions | |
US9373807B2 (en) | Radiative fibers | |
US20170100607A1 (en) | Fibers in therapy and cosmetics | |
JP6388900B2 (ja) | 細胞および細胞組織の処置のためのデバイスおよび方法 | |
US20130226268A1 (en) | Nanocrystals in devices | |
US9385337B2 (en) | Nanocrystals on fibers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10776951 Country of ref document: EP Kind code of ref document: A1 |
|
REEP | Request for entry into the european phase |
Ref document number: 2010776951 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010776951 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13514879 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012542381 Country of ref document: JP |
|
ENP | Entry into the national phase |
Ref document number: 20127017724 Country of ref document: KR Kind code of ref document: A |