WO2011058988A1 - Feuille support d'un agent antiviral et procédé de fabrication de celle-ci - Google Patents

Feuille support d'un agent antiviral et procédé de fabrication de celle-ci Download PDF

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Publication number
WO2011058988A1
WO2011058988A1 PCT/JP2010/069982 JP2010069982W WO2011058988A1 WO 2011058988 A1 WO2011058988 A1 WO 2011058988A1 JP 2010069982 W JP2010069982 W JP 2010069982W WO 2011058988 A1 WO2011058988 A1 WO 2011058988A1
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Prior art keywords
antiviral agent
aqueous
polyvinyl alcohol
adhesive
alcohol
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PCT/JP2010/069982
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English (en)
Japanese (ja)
Inventor
宗紀 山田
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ユニチカ株式会社
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Publication date
Priority claimed from JP2009258447A external-priority patent/JP5483548B2/ja
Priority claimed from JP2009258446A external-priority patent/JP5398483B2/ja
Application filed by ユニチカ株式会社 filed Critical ユニチカ株式会社
Publication of WO2011058988A1 publication Critical patent/WO2011058988A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
    • A62B23/00—Filters for breathing-protection purposes
    • A62B23/02—Filters for breathing-protection purposes for respirators

Definitions

  • the present invention relates to a carrier sheet carrying an antiviral agent such as an anti-influenza virus agent, and in particular, a carrier sheet carrying an anti-influenza virus agent having a function of inactivating new influenza viruses such as swine influenza virus and avian influenza virus. It is about.
  • swine flu is prevalent worldwide. Although swine flu has a lower mortality rate than bird flu, pregnant women, those under 5 years old or over 60 years old, and people with underlying diseases are more likely to become serious at the time of infection, and infection prevention is essential. ing. In particular, medical workers are constantly exposed to the risk of contact infection caused by touching sheets of towels, bedspreads, curtains and the like around the infected person.
  • a sanitary mask when going out, not only for new influenza such as swine flu but also for old influenza.
  • Sanitary masks include gauze masks and non-woven masks, but since gauze masks are sheet-like materials made of gauze with coarse eyes, influenza viruses can invade from here and are said to be less effective in preventing infection. ing.
  • Non-woven masks are said to be more effective in preventing infection than gauze masks because the mask body is a sheet of fine-grained non-woven fabric, but the effects of preventing infection are still questioned. .
  • Patent Document 1 a virus agent such as an anti-influenza virus to various sheet-like materials such as nonwoven fabrics and knitted fabrics.
  • the antiviral agent described in Patent Document 1 is a fine particle made of a hydrate of a metal oxide, generates a hydroxy radical, and inactivates a virus such as influenza virus by the hydroxy radical. In order to attach such fine particles to the sheet-like material, it is necessary to use an adhesive.
  • aqueous solution type such as an aqueous solution type, an aqueous emulsion type, a solvent type, and a hot melt type
  • the adhesive is used when attaching fine particles to a sheet-like material.
  • covered fine particles sometimes covered fine particles.
  • fine-particles did not continue for a long time by this coating. That is, the part of fine particles not covered by the adhesive film (exposed part) only shows antiviral activity at the beginning, and the part that is covered (unexposed part) uses antiviral activity. It is considered that such a drawback is caused by the fact that it is not done.
  • JP 2008-37814 A (Claims and paragraph number 0025)
  • An object of the present invention is to solve the above-mentioned drawbacks, and to provide a sheet-like material in which antiviral activity can be maintained for a long time even when a particulate anti-viral agent is attached to the sheet-like material with an adhesive. It is in.
  • the inventor of the present invention has examined the antiviral activity by attaching the fine particles described in Patent Document 1 to a sheet-like material with various adhesives.
  • the antiviral activity is long only when a specific adhesive is used. Found to last for hours.
  • the present invention has been made based on such knowledge.
  • the present invention provides an antiviral agent-supporting sheet comprising a particulate antiviral agent that generates hydroxy radicals attached to a sheet with an adhesive containing polyvinyl alcohol having a polymerization degree of 250 to 1000, and It relates to the manufacturing method.
  • Examples of the particulate antiviral agent used in the present invention include those described in Patent Document 1 and International Publication No. 2005/013695. That is, dolomite (dolomite) is fired, hydrated, and then pulverized into fine particles.
  • the composition of the fine particles is mainly composed of CaCO 3 , Ca (OH) 2 and Mg (OH) 2 .
  • the average particle diameter of the fine particles is about 0.1 to 60 ⁇ m.
  • Such antiviral agents generate hydroxy radicals. Hydroxyl radicals inactivate viruses such as old influenza viruses, herpes viruses and retroviruses as well as new influenza viruses such as swine influenza virus and avian influenza virus.
  • Such a particulate antiviral agent is adhered to a sheet by an adhesive.
  • the present invention is characterized by the adhesive used at this time. That is, by using an adhesive containing polyvinyl alcohol having a polymerization degree of 250 to 1000, generation of hydroxy radicals can be sustained for a long time.
  • an adhesive containing polyvinyl alcohol having a polymerization degree of 250 to 1000 generation of hydroxy radicals can be sustained for a long time.
  • a urethane or fluorine-acrylic adhesive is used as the adhesive, the generation of hydroxy radicals is difficult to last for a long time. The reason for this is not clear, but since polyvinyl alcohol has a hydroxy group, it is presumed that the hydroxy radical generated from the antiviral agent is difficult to bind to polyvinyl alcohol.
  • urethane adhesives and fluorine-acrylic adhesives it is presumed that hydroxy radicals generated from antiviral agents are bonded to urethane bonding groups in these adhesives and disappear.
  • the reason for setting the polymerization degree of polyvinyl alcohol to 250 to 1000 is that it is easy to handle as an aqueous solution and sufficiently exhibits an adhesive action.
  • the saponification degree of polyvinyl alcohol is preferably about 35 to 99 mol%. In particular, it is preferably 66 to 99 mol%, more preferably 90 to 99 mol%.
  • the saponification degree is extremely low, it is considered that the hydroxy group is almost lost, and the generation of hydroxy radicals from the antiviral agent is difficult to sustain for a long time. Further, when the degree of saponification becomes extremely high, it becomes difficult to handle because it becomes difficult to dissolve in water.
  • An adhesive containing polyvinyl alcohol is generally used in the form of an aqueous solution. That is, when a particulate antiviral agent is dispersed and an aqueous adhesive solution in which polyvinyl alcohol is dissolved is applied to a sheet by a coating method or a dipping method, and then dried, a sheet is obtained. An antiviral agent can be attached to.
  • the adhesive aqueous solution containing polyvinyl alcohol further contains a particulate polyolefin resin having a number average particle diameter of 1 ⁇ m or less.
  • an antiviral agent can be adhered by the adhesive action of polyvinyl alcohol, but if a larger amount of antiviral agent is to be adhered or if it is desired to adhere firmly, polyolefin resin fine particles having an adhesive action. Is preferably added.
  • the number average particle diameter of the polyolefin resin fine particles is preferably 1 ⁇ m or less.
  • the number average particle diameter of the polyolefin resin fine particles was obtained using “Microtrac particle size distribution analyzer UPA150 (MODEL No. 9340)” manufactured by Nikkiso Co., Ltd. If the number average particle diameter is too large, Tends to be difficult to disperse well.
  • a polyolefin resin that is easily dispersed in water.
  • a polyolefin resin was developed by the present applicant and is described in Japanese Patent No. 3699935, and (A1) an unsaturated carboxylic acid or an anhydride thereof and (A2) having 2 to 6 carbon atoms. It consists of a copolymer obtained by copolymerizing a monomer containing alkene.
  • A1 As the unsaturated carboxylic acid or its anhydride, acrylic acid, methacrylic acid, maleic acid, maleic anhydride, itaconic acid, itaconic anhydride, fumaric acid, crotonic acid and the like are used.
  • alkene having 2 to 6 carbon atoms ethylene, propylene, isobutylene, 1-butene, 1-pentene, 1-hexene and the like are used.
  • An acrylic ester may be copolymerized as the third component.
  • a third component such as acrylic amide, methacrylic amide, methyl vinyl ether, ethyl vinyl ether, vinyl formate, vinyl acetate, vinyl propionate, vinyl pivalate, vinyl versatate, vinyl alcohol, acrylonitrile may be copolymerized. Absent.
  • the third component is copolymerized, it is copolymerized in an amount of about 35% by mass or less.
  • the polyolefin resin fine particles having the above composition are well dispersed in water as described in Japanese Patent No. 3699935. Therefore, even if this polyolefin resin fine particle is added to an aqueous adhesive solution containing polyvinyl alcohol, it can be dispersed well in the aqueous solution and used as a uniform aqueous adhesive solution.
  • an aqueous dispersion is prepared by dispersing a particulate antiviral agent in an aqueous solvent comprising water and alcohol.
  • alcohol used in the aqueous solvent is to improve the permeability to the fiber gap when the sheet-like material has a fiber gap like a nonwoven fabric or a knitted fabric.
  • a lower alcohol such as ethanol has a lower boiling point than water and is preferable because it can be evaporated together with water.
  • an aqueous solution in which polyvinyl alcohol having a polymerization degree of 250 to 1000 is dissolved is added to this aqueous dispersion to obtain an aqueous adhesive solution containing polyvinyl alcohol and an antiviral agent.
  • this adhesive aqueous solution it is applied to a sheet-like material by a conventionally known means such as dipping, coating or spraying. And when it dries and the water in aqueous solution is evaporated, a microparticulate antiviral agent will adhere to a sheet-like material with polyvinyl alcohol which is an adhesive agent.
  • a polyolefin resin fine particle dispersion in which a fine polyolefin resin having a number average particle size of 1 ⁇ m or less is dispersed in water in an aqueous adhesive solution containing polyvinyl alcohol and an antiviral agent. What is necessary is just to add and mix a liquid.
  • This polyolefin resin fine particle dispersion may also be prepared by dispersing it in an aqueous solvent composed of water and alcohol.
  • the alcohol is used in combination for the same reason as described above and to improve the dispersibility of the particulate polyolefin resin.
  • the alcohol used is preferably a lower alcohol such as ethanol for the same reason as described above.
  • any material such as non-woven fabric, paper, knitted fabric, plastic film, metal foil or the like is used.
  • Sheet-like materials used as materials such as sanitary masks, towels, and curtains are often non-woven fabrics and knitted fabrics, and therefore these are preferably used.
  • an adhesive composed of polyolefin resin fine particles may be used for the purpose of improving the adhesiveness of the antiviral agent (adhesion amount of the antiviral agent and its adhesive force).
  • an adhesive composed of polyolefin resin fine particles may be used for the purpose of improving the adhesiveness of the antiviral agent (adhesion amount of the antiviral agent and its adhesive force).
  • an adhesive composed of polyolefin resin fine particles may be used for the purpose of improving the adhesiveness of the antiviral agent (adhesion amount of the antiviral agent and its adhesive force).
  • polyolefin fibers include polypropylene fibers and polyethylene fibers.
  • a core-sheath type composite long fiber whose core component is made of polyester having a high melting point and whose sheath component is made of polyolefin such as polyethylene or polypropylene having a low melting point.
  • the non-woven fabric can be obtained by bonding the long fibers by fusing only the sheath component, and a non-woven fabric with good form stability can be obtained without curing the texture. Because it is.
  • the antiviral agent-carrying sheet according to the present invention is used for arbitrary purposes.
  • a nonwoven fabric or a knitted fabric is used as the sheet-like material
  • various uses in which the nonwoven fabric or the knitted fabric is conventionally used such as sanitary masks, curtains, bandages, surgical gowns, bed sheets, towels, gloves, It can be used as a filter material for carpets and air conditioners.
  • paper when paper is used as the sheet-like material, it can be used for various uses in which paper has been conventionally used, such as wallpaper and paper towels.
  • a particulate antiviral agent that generates hydroxy radicals is adhered to a sheet material with an adhesive containing polyvinyl alcohol having a polymerization degree of 250 to 1000. And this polyvinyl alcohol is hard to inhibit generation
  • the present invention will be described based on examples, but the present invention is not limited to the examples.
  • the present invention should be understood as being based on the knowledge that even if the surface of the particulate antiviral agent that generates hydroxy radicals is coated with polyvinyl alcohol, the generation of hydroxy radicals is not inhibited.
  • Example 1 While stirring a dispersion in which 375 g of a particulate anti-influenza virus agent (product name “BR-p 3 ” manufactured by Mochigase Co., Ltd.) is dispersed in 2125 g of water, 542 g of ethanol is added, and an aqueous system composed of water and ethanol An aqueous dispersion in which an anti-influenza virus agent is dispersed in a solvent was prepared. On the other hand, 744 g of an aqueous polyvinyl alcohol solution having a solid content concentration of 10% by mass was prepared by dissolving polyvinyl alcohol (trade name “JF-03”, manufactured by Nihon Vinegar Bipoval Co., Ltd.) in water.
  • a particulate anti-influenza virus agent product name “BR-p 3 ” manufactured by Mochigase Co., Ltd.
  • the polyvinyl alcohol used here has a polymerization degree of 300 and a saponification degree of 98 to 99 mol%. Then, while stirring the aqueous dispersion, an aqueous polyvinyl alcohol solution was added to obtain an aqueous adhesive solution.
  • the concentration of the anti-influenza virus agent in this aqueous adhesive solution is about 10% by mass, and the concentration of the adhesive made of polyvinyl alcohol is about 2% by mass.
  • aqueous solution After this adhesive aqueous solution has been stored for 4 days, it is applied to a spunbonded nonwoven fabric (manufactured by Unitika Ltd., trade name “Elves S0503 WDO”, basis weight 50 g / m 2 ) by a gravure coating method, and then dried at 110 ° C. for 2 minutes.
  • a test piece 1 having an anti-influenza virus agent attached to a spunbonded nonwoven fabric (sheet-like material) was obtained.
  • the spunbond nonwoven fabric used here is composed of a core-sheath type composite continuous fiber having a core component made of polyester and a sheath component made of polyethylene. It is what you have.
  • the adhesion amounts of the anti-influenza virus agent and polyvinyl alcohol to the fiber substrate were about 12 to 15 g / m 2 . Therefore, the adhesion amount of the anti-influenza virus agent is about 10 to 12.5 g / m 2 .
  • Example 2 While stirring a dispersion liquid in which 375 g of a microparticulate anti-influenza virus agent (trade name “BR-p 3 ” manufactured by Mochigase Co., Ltd.) is dispersed in 2125 g of water, 140 g of ethanol is added to form an aqueous system composed of water and ethanol. An aqueous dispersion in which an anti-influenza virus agent is dispersed in a solvent was prepared.
  • a microparticulate anti-influenza virus agent trade name “BR-p 3 ” manufactured by Mochigase Co., Ltd.
  • an aqueous polyvinyl alcohol solution having a solid content concentration of 10% by mass by dissolving polyvinyl alcohol (trade name “JMR-10L”, manufactured by Nihon Vinegar Bipoval Co., Ltd.) in a mixed solvent in which 268 g of water and 402 g of ethanol are mixed. 744 g was prepared.
  • the polyvinyl alcohol used here has a polymerization degree of 250 and a saponification degree of 35 to 36 mol%. Then, while stirring the aqueous dispersion, an aqueous polyvinyl alcohol solution was added to obtain an aqueous adhesive solution.
  • the concentration of the anti-influenza virus agent in the adhesive aqueous solution is about 10% by mass, and the concentration of the adhesive made of polyvinyl alcohol is about 2% by mass. Thereafter, using this adhesive aqueous solution, an anti-influenza virus agent was adhered to the spunbonded nonwoven fabric in the same manner as in Example 1 to obtain a test piece 2.
  • Example 3 The same method as in Example 1 except that polyvinyl alcohol (trade name “JMR-10M”, manufactured by Nippon Vinegar Bipovar Co., Ltd.) is used instead of polyvinyl alcohol (trade name “JF-03”, manufactured by Nihon Vinegar Bipoval Co., Ltd.). Thus, a test piece 3 was obtained.
  • the polyvinyl alcohol used here has a polymerization degree of 250 and a saponification degree of 66 to 67 mol%.
  • Example 4 instead of polyvinyl alcohol (trade name “JF-03”, manufactured by Nihon Vinegar Bipoval), polyvinyl alcohol (trade name “VC-10”, manufactured by Nihon Vinegar Bipobar) was used, and the solid content concentration of the aqueous polyvinyl alcohol solution was used.
  • the test piece 4 was obtained by the same method as Example 1 except having made 8 mass%.
  • the polyvinyl alcohol used here has a polymerization degree of 1000 and a saponification degree of 99 mol%.
  • Example 5 While stirring a dispersion in which 375 g of a particulate anti-influenza virus agent (product name “BR-p 3 ” manufactured by Mochigase Co., Ltd.) is dispersed in 2125 g of water, 542 g of ethanol is added, and an aqueous system composed of water and ethanol An aqueous dispersion in which an anti-influenza virus agent is dispersed in a solvent was prepared. On the other hand, 248 g of an aqueous polyvinyl alcohol solution having a solid content concentration of 10% by mass was prepared by dissolving polyvinyl alcohol (trade name “JF-03”, manufactured by Nihon Vinegar Bipoval Co., Ltd.) in water.
  • a particulate anti-influenza virus agent product name “BR-p 3 ” manufactured by Mochigase Co., Ltd.
  • the resulting polyolefin resin fine particle dispersion was milky white, and the number average particle size of the fine particles was about 0.06 ⁇ m.
  • the polyolefin resin used here is a copolymer composed of 80% by mass of ethylene, 18% by mass of ethyl acrylate, and 2% by mass of maleic anhydride, and has a melting point of 81 ° C.
  • a test piece 5 in which an anti-influenza virus agent was adhered to a spunbonded nonwoven fabric (sheet-like material) was obtained in the same manner as in Example 1.
  • the adhesion amount of the anti-influenza virus agent, polyvinyl alcohol and polyolefin resin fine particles to the sheet was about 12 to 15 g / m 2 . Therefore, the adhesion amount of the anti-influenza virus agent is about 10 to 12.7 g / m 2 .
  • Example 6 instead of polyvinyl alcohol (trade name “JF-03”, manufactured by Nihon Vinegar Bipoval), polyvinyl alcohol (trade name “VC-10”, manufactured by Nihon Vinegar Bipobar) was used, and the solid content concentration of the aqueous polyvinyl alcohol solution was used.
  • a test piece 6 was obtained by the same method as in Example 5 except that the content was 8 mass%.
  • Comparative Example 1 Instead of a polyvinyl alcohol aqueous solution having a solid content concentration of 10% by mass in which polyvinyl alcohol (trade name “JF-03” manufactured by Nippon Vinegar Bipoval Co., Ltd.) is dissolved, an aqueous polyether type polyurethane resin dispersion (manufactured by Enomoto Kasei Co., Ltd., product) The name “Neolet's R-600”, polyurethane weight average molecular weight 37,000, solid content concentration 33% by mass) diluted with water to a solid content concentration of 10% by mass was used as the adhesive solution.
  • a test piece 7 was obtained by the same method as in Example 1.
  • Comparative Example 2 Instead of polyvinyl alcohol aqueous solution with a solid content concentration of 10% by mass in which polyvinyl alcohol (trade name “JF-03” manufactured by Nippon Vinegar Bipovar Co., Ltd.) is dissolved, a fluorine-acrylic resin emulsion (product name “Asahi Guard” manufactured by Asahi Glass Co., Ltd.) The test piece 8 was prepared in the same manner as in Example 1 except that AG-7000 "(solid content concentration 20% by mass) was diluted with water so that the solid content concentration was 10% by mass as the adhesive solution. Obtained.
  • the covering time was set to 15 seconds, 30 seconds, 45 seconds, 60 seconds, and 120 seconds, and then the anti-influenza virus activity after 20 minutes was evaluated. Since this evaluation is known to have a correlation between anti-influenza virus activity and pH, a thymolphthalein indicator is used, which is sprayed onto the site of the test piece covering the mouth of the mayonnaise bottle, It depends on the degree of color development. In other words, if all the sites of the test piece are colored, the anti-influenza virus activity is completely effective, so it is 10 points. If all the sites are not colored, the anti-influenza virus activity is invalid, the score is 0. Evaluation was performed by scoring 1 to 9 points according to the area of the part. The results were as shown in Table 1.
  • Test piece 1 ⁇ 15 seconds later 30 seconds later 45 seconds later 60 seconds later 120 seconds later ⁇ Test piece 1 10 10 8 8 5 Test piece 2 10 8 6 5 2 Test piece 3 10 9 8 6 5 Test piece 4 10 9 10 9 4 Test piece 5 10 9 8 8 6 Test piece 6 10 9 7 6 5 ⁇ Test piece 7 10 5 2 0 0 Test piece 8 9 3 0 0 0 ⁇
  • test pieces 1 to 6 obtained in Examples 1 to 6 show almost good anti-influenza virus activity even after contact with carbon dioxide for 45 seconds.
  • test pieces 7 and 8 obtained in Comparative Examples 1 and 2 have almost no anti-influenza virus activity even after contact with carbon dioxide for 45 seconds. Therefore, the test pieces obtained in Examples 1 to 6 have anti-influenza virus activity for a long time. Therefore, if a carrier sheet made of such a test piece is applied to the respiratory passage of the sanitary mask body or used for various other purposes, contact infection of influenza virus can be prevented, which is beneficial for prevention of influenza infection. is there.

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Abstract

L'invention concerne une feuille support d'un agent antiviral dont l'activité antivirale telle qu'une activité contre le virus de la grippe se poursuit sur une longue période. Dans cette feuille support, un agent antivirus tel qu'un agent contre le virus de la grippe sous forme de fines particules générant des radicaux hydroxyles, est appliqué à l'aide d'un agent adhésif sur un objet en forme de feuille. De fines particules pulvérisées obtenues par cuisson puis hydratation d'une dolomite, sont mises en œuvre en tant qu'agent antivirus sous forme de fines particules. L'agent adhésif contient un alcool polyvinylique dont le degré de polymérisation est de 250 à 1000. De préférence, le degré de saponification de l'alcool polyvinylique est de 35 à 99% en moles. L'agent adhésif peut également contenir une résine de polyoléfine sous forme de fine particules d'un diamètre de particule moyen en nombre inférieur ou égal à 1µm. En outre, un tissu non tissé, un objet en textile tricoté / tissé, un papier, ou similaire, peuvent être mis en œuvre en tant qu'objet en forme de feuille.
PCT/JP2010/069982 2009-11-11 2010-11-10 Feuille support d'un agent antiviral et procédé de fabrication de celle-ci WO2011058988A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009258447A JP5483548B2 (ja) 2009-11-11 2009-11-11 抗ウイルス剤担持シート及びその製造方法
JP2009-258447 2009-11-11
JP2009-258446 2009-11-11
JP2009258446A JP5398483B2 (ja) 2009-11-11 2009-11-11 衛生マスク

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011101758A (ja) * 2009-11-11 2011-05-26 Unitika Ltd 衛生マスク
JP2013087064A (ja) * 2011-10-14 2013-05-13 Nbc Meshtec Inc ウイルス不活化シート

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1123839A (ja) * 1997-07-04 1999-01-29 Nippon Synthetic Chem Ind Co Ltd:The 偏光板
JPH1161569A (ja) * 1997-08-19 1999-03-05 Unitika Ltd 抗菌性複合繊維
JP2003119328A (ja) * 2001-01-15 2003-04-23 Unitika Ltd ポリオレフィン樹脂水性分散体及びその製造方法
WO2005013695A1 (fr) * 2003-08-12 2005-02-17 Mochigase Electrical Equipment Co., Ltd. Agent antiviral ainsi que fibres et elements antiviraux pourvus dudit agent
JP2008037814A (ja) * 2006-08-08 2008-02-21 Tokyo Medical & Dental Univ 抗ウイルス材及び環境反応型抗ウイルス材

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1123839A (ja) * 1997-07-04 1999-01-29 Nippon Synthetic Chem Ind Co Ltd:The 偏光板
JPH1161569A (ja) * 1997-08-19 1999-03-05 Unitika Ltd 抗菌性複合繊維
JP2003119328A (ja) * 2001-01-15 2003-04-23 Unitika Ltd ポリオレフィン樹脂水性分散体及びその製造方法
WO2005013695A1 (fr) * 2003-08-12 2005-02-17 Mochigase Electrical Equipment Co., Ltd. Agent antiviral ainsi que fibres et elements antiviraux pourvus dudit agent
JP2008037814A (ja) * 2006-08-08 2008-02-21 Tokyo Medical & Dental Univ 抗ウイルス材及び環境反応型抗ウイルス材

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011101758A (ja) * 2009-11-11 2011-05-26 Unitika Ltd 衛生マスク
JP2013087064A (ja) * 2011-10-14 2013-05-13 Nbc Meshtec Inc ウイルス不活化シート

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