WO2011031077A3 - 동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질 - Google Patents

동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질 Download PDF

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Publication number
WO2011031077A3
WO2011031077A3 PCT/KR2010/006146 KR2010006146W WO2011031077A3 WO 2011031077 A3 WO2011031077 A3 WO 2011031077A3 KR 2010006146 W KR2010006146 W KR 2010006146W WO 2011031077 A3 WO2011031077 A3 WO 2011031077A3
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WO
WIPO (PCT)
Prior art keywords
dermal matrix
acellular dermal
cryopreserved
cryopreserved acellular
production method
Prior art date
Application number
PCT/KR2010/006146
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English (en)
French (fr)
Other versions
WO2011031077A2 (ko
Inventor
전욱
최원익
박만성
김근형
정재득
Original Assignee
한림대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 한림대학교 산학협력단 filed Critical 한림대학교 산학협력단
Priority to CN201080040509.9A priority Critical patent/CN102573945B/zh
Priority to US13/392,596 priority patent/US20120189707A1/en
Publication of WO2011031077A2 publication Critical patent/WO2011031077A2/ko
Publication of WO2011031077A3 publication Critical patent/WO2011031077A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Abstract

본 발명은 동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질에 관한 것으로서, 더욱 상세하게는 글리세롤 및 기본 용액을 기본 성분으로 하여 이에 수크로스를 첨가하여 동결 보호제를 만들고, 이 용액을 이용하여 표피 및 진피 내 세포가 제거된 피부 조직을 동결보존 처리하는 방법 및 그로부터 제조된 동결보존 무세포 진피 기질에 관한 것이다.
PCT/KR2010/006146 2009-09-11 2010-09-09 동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질 WO2011031077A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201080040509.9A CN102573945B (zh) 2009-09-11 2010-09-09 冷冻保存无细胞真皮基质的制备方法及由其制备的冷冻保存无细胞真皮基质
US13/392,596 US20120189707A1 (en) 2009-09-11 2010-09-09 Production Method For Cryopreserved Acellular Dermal Matrix, And Cryopreserved Acellular Dermal Matrix Produced Thereby

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090085666A KR101107022B1 (ko) 2009-09-11 2009-09-11 동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질
KR10-2009-0085666 2009-09-11

Publications (2)

Publication Number Publication Date
WO2011031077A2 WO2011031077A2 (ko) 2011-03-17
WO2011031077A3 true WO2011031077A3 (ko) 2011-07-14

Family

ID=43732955

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/006146 WO2011031077A2 (ko) 2009-09-11 2010-09-09 동결보존 무세포 진피 기질의 제조 방법 및 그로부터 제조된 동결보존 무세포 진피 기질

Country Status (4)

Country Link
US (1) US20120189707A1 (ko)
KR (1) KR101107022B1 (ko)
CN (1) CN102573945B (ko)
WO (1) WO2011031077A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
KR101362402B1 (ko) * 2012-03-15 2014-02-14 김준용 기저막층이 제거된 무세포 진피조직 이식체
CA2897855A1 (en) 2013-03-07 2014-09-12 Allosource Consistent calcium content bone allograft systems and methods
KR102040592B1 (ko) * 2013-03-18 2019-11-06 주식회사 엘앤씨바이오 생체 이식물 제조방법
CN103285420B (zh) * 2013-03-28 2015-03-25 北京桀亚莱福生物技术有限责任公司 一种用于覆盖烧伤创伤创面的人体生物敷料的制作方法
CN103990179B (zh) * 2014-05-24 2017-08-29 河北爱能生物科技股份有限公司 一种制备异种脱细胞基质的方法及其产品
CN106310384A (zh) * 2015-07-01 2017-01-11 江西瑞诺健医学科技有限公司 一种脱细胞异种真皮及其制取方法
WO2017075608A1 (en) 2015-10-30 2017-05-04 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Suture sleeve patch and methods of delivery within an existing arphroscopic workflow
US11523812B2 (en) 2016-02-01 2022-12-13 Medos International Sarl Soft tissue fixation repair methods using tissue augmentation constructs
US11484401B2 (en) 2016-02-01 2022-11-01 Medos International Sarl Tissue augmentation scaffolds for use in soft tissue fixation repair
CN105833353B (zh) * 2016-05-09 2018-04-20 拜欧迪赛尔（北京）生物科技有限公司 一种生物工程脱细胞真皮基质的制备及用途
CN105833356B (zh) * 2016-05-09 2018-02-16 拜欧迪赛尔（北京）生物科技有限公司 一种新型的脱细胞带瓣血管支架及其制备方法
CN105879118B (zh) * 2016-05-09 2018-03-02 拜欧迪赛尔（北京）生物科技有限公司 一种生物工程脱细胞软骨的制备方法
CN105944142B (zh) * 2016-05-09 2018-07-13 拜欧迪赛尔（北京）生物科技有限公司 一种脱细胞肌腱或韧带支架的制备方法
PL236127B1 (pl) * 2018-08-24 2020-12-14 Xenogp Spolka Z Ograniczona Odpowiedzialnoscia Sposób otrzymywania opatrunku ze skóry świńskiej oraz zastosowanie medyczne opatrunku ze skóry świńskiej
CN111982629B (zh) * 2020-08-25 2023-11-17 北京市农林科学院 一种食用菌组织细胞的超薄冷冻切片方法
WO2022131407A1 (ko) * 2020-12-18 2022-06-23 주식회사 엘앤씨바이오 기저막층을 포함하는 진피 기반 인공 피부 및 그 제조방법

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KR20060099312A (ko) * 2005-03-11 2006-09-19 경상남도 세포성 인공조직의 장기보관을 위한 무혈청성 동결보존액및 이를 이용한 세포성 인공조직의 동결보존방법

Also Published As

Publication number Publication date
US20120189707A1 (en) 2012-07-26
CN102573945B (zh) 2015-03-25
WO2011031077A2 (ko) 2011-03-17
CN102573945A (zh) 2012-07-11
KR20110027880A (ko) 2011-03-17
KR101107022B1 (ko) 2012-01-25

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