WO2011025120A2 - Composition pour effacer les abus d'alcool et composition pour restaurer la fonction hépatique avec de l'eau de source chaude - Google Patents

Composition pour effacer les abus d'alcool et composition pour restaurer la fonction hépatique avec de l'eau de source chaude Download PDF

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WO2011025120A2
WO2011025120A2 PCT/KR2010/002464 KR2010002464W WO2011025120A2 WO 2011025120 A2 WO2011025120 A2 WO 2011025120A2 KR 2010002464 W KR2010002464 W KR 2010002464W WO 2011025120 A2 WO2011025120 A2 WO 2011025120A2
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extract
composition
water
powder
stems
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PCT/KR2010/002464
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Korean (ko)
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WO2011025120A3 (fr
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남종현
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Nam Jong Hyun
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A23L2/08—Concentrating or drying of juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/154—Water
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/204—Animal extracts
    • A23V2250/2042—Marine animal, fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A23V2250/2124—Ginseng
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/502—Gums
    • A23V2250/5022—Acacia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/502—Gums
    • A23V2250/5072—Pectine, pectinate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/502—Gums
    • A23V2250/5086—Xanthan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins

Definitions

  • the present invention relates to a composition for relieving hangover using hot spring water and a composition for restoring liver function.
  • the present invention has been completed by confirming that when hot spring water is mixed with alder extract, rowan extract and acacia extract, it has a synergistic effect on hangover relieving activity.
  • the technical problem of the present invention is to provide a hangover composition.
  • Another technical problem of the present invention is to provide a composition for restoring liver function.
  • the present invention relates to a hangover composition.
  • Hangovers such as nausea and headaches after heavy drinking, are caused by aldehydes that occur during alcohol metabolism.
  • alcoholase (ADH) and aldehydease (ALDH) are present in the liver, and when alcohol enters the body, it is converted into acetate, which is harmless to the body.
  • the inventors found that the hot spring water known to have a hangover relieving effect, the Acacia extract (Korean Patent No. 0718189), rowan extract and alder tree, which the inventors have already patented for the hangover relieving activity.
  • the extract Korean Patent No. 0111168
  • ADH alcohol and enzymes
  • ALDH aldehyde degrading enzyme
  • Hangover composition of the present invention is provided based on the results of these experiments, in addition to the acacia extract, rowan extract and alder extract is characterized in that the hot spring water or its concentrate as an active ingredient.
  • active ingredient alone refers to a component that can exhibit the desired activity or exhibit itself with a carrier which is inactive.
  • acacia extract refers to acacia leaves, stems, flowers, roots or mixtures thereof, regardless of the extraction method, methanol, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform, methylene chloride, water, Or an extract obtained by extraction with a mixed solvent thereof and an extract fractionated with the solvents listed above in the extract.
  • the extraction method may be applied to any method such as cooling, refluxing, heating, and ultrasonic wave. It should be understood that it can.
  • the "acacia extract” is preferably obtained by extracting acacia leaves, stems, flowers, roots or mixtures thereof to be extracted with water, ethanol or a mixed solvent thereof, wherein the concentrated liquid extract from which the extraction solvent is removed or It is meant to include solid extracts.
  • a rowan extract may be defined the same as the “acacia extract” except that the extraction target is rowan leaves, stems, roots or mixtures thereof.
  • the "duckwood extract” may be defined in the same manner as the “acacia extract” except that the extraction target is alder leaves, stems, roots or a mixture thereof.
  • hot spring water is defined as water having a temperature higher than the temperature of water at room temperature by being heated by geothermal heat in the ground, and thus, ground water, ground water, and the like, which are not heated by geothermal heat, are used in the meaning of the hot spring water. Excluded. Preferably, it is defined as harvested at an excavation depth of 1,000m, 779-6, Guntan-ri, Galmal-eup, Cheorwon-gun, Gangwon-do, used in the following examples. In addition, more preferably considering that the hangover elimination effect of the hot spring water is due to the mineral component contained in the hot spring water, the "hot spring water” may be defined as having the mineral component as described in FIG.
  • excavation depth means an excavation depth based on the ground surface.
  • the "concentrate of hot water” means any thing obtained when dehydrating hot spring water. When fully dehydrated, the result will be obtained in powder form, the “concentrate of hot water” includes the result in powder form. The result in powder form would be the composition of the mineral components contained in the hot spring water.
  • the hangover composition of the present invention may contain any amount (effective amount) as long as the active ingredient acacia extract, rowan extract, alder extract and hot spring water (or its concentrate) can exhibit the hangover removal activity.
  • Typical effective amounts will be determined within the range of 0.001% to 99.900% by weight based on the total weight of the composition.
  • the term "effective amount" herein refers to an amount of an active ingredient that can induce prevention, amelioration, treatment of a symptom caused by a hangover, or delay in the expression of such a symptom. Such effective amounts can be determined experimentally within the range of ordinary skill in the art.
  • Hangover-relieving composition of the present invention is known to have a hangover removal activity to increase and enhance the hangover elimination activity, in addition to the acacia extract, rowan extract, alder extract and hot spring water (or its concentrates) as its active ingredient
  • acacia extract, rowan extract, alder extract and hot spring water (or its concentrates) as its active ingredient
  • Known natural products or compounds may be included.
  • Such natural products or compounds include edible powder or extract, bean sprout powder or extract, shellfish powder or extract, oyster powder or extract, hawthorn powder or extract, radish juice or extract, cucumber juice or extract, leek juice or extract, spinach juice or extract , Lotus root juice or extract, sesame juice or extract, pine needle juice or extract, ginseng juice or extract, birch powder or extract, licorice powder or extract, brownish powder or extract, reed powder or extract, sine powder or extract, gourd powder or Extract, Ginger Powder or Extract, Jujube Powder or Extract, Human Powder or Extract, Earth Powder or Extract, Hydrophobic Powder or Extract, White Extract Powder or Extract, Spirit Powder or Extract, Dermis Powder or Extract, Wolfberry Powder or extract, green tea powder or extract, Schisandra chinensis Or it can be illustrated extracts, heotgae tree extract, fig extract, nogeun Extract, Cinnamon Extract, and Decker during play.
  • the meaning of the extract in the above is as described above with respect to the a
  • the present invention relates to a liver function recovery composition
  • a liver function recovery composition comprising hot spring water or concentrates thereof as an active ingredient in addition to acacia extract, rowan extract and alder extract.
  • beverages prepared by using acacia extract, rowan extract and alder extract with hot spring water were produced by alcohol administration, compared to beverages prepared using water instead of hot spring water.
  • Acacia extract, rowan extract, and alder extract in combination with hot spring water in that they significantly lower the activity of glutamate pyruvate transaminase ("GPT") and glutamate oxaloacetate transaminase (“GOT”). It can also be useful for recovery purposes.
  • GPT glutamate pyruvate transaminase
  • GAT glutamate oxaloacetate transaminase
  • GPT and GOT are enzymes that are used as general indicators of liver dysfunction because the liver is secreted into the blood from the liver when damaged due to alcohol or the like.
  • liver function is meant to include preventing, ameliorating, treating, or delaying the onset of liver damage caused by alcohol or the like.
  • composition for restoring liver function of the present invention in relation to known natural products or compounds which can be used together with the active ingredient for the increase and reinforcement of the content of the active ingredient and the effect of restoring liver function, As described in relation to the composition is applied mutatis mutandis.
  • composition of the present invention can be regarded as a food composition, in particular a functional drink, in a specific embodiment.
  • the food composition of the present invention may include a sweetening agent, a flavoring agent, a bioactive component, a mineral component, and the like.
  • Sweeteners may be used in amounts that give the food a suitable sweet taste, and may be natural or synthetic.
  • a natural sweetener is used.
  • sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
  • Flavoring agents can be used to enhance the taste or aroma of foods, both natural and synthetic. It is the case of using a natural thing preferably.
  • the natural flavor may be obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or may be obtained from green tea leaves, round leaves, date leaves, cinnamon, chrysanthemum leaves, jasmine and the like.
  • ginseng red ginseng
  • bamboo shoots aloe vera, ginkgo and the like
  • Natural flavors can be liquid concentrates or solid extracts.
  • synthetic flavoring agents may be used, and synthetic flavoring agents may be used in the form of esters, alcohols, aldehydes, terpenes and the like.
  • catechins such as catechin, epicatechin, gallocatechin, epigallocatechin, vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine, riboflavin, and the like can be used.
  • mineral component calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium, zinc and the like can be used. .
  • the food composition of the present invention may contain a preservative, an emulsifier, an acidulant, a thickener, and the like, in addition to the sweetener.
  • Such preservatives, emulsifiers and the like are preferably added and used in very small amounts as long as the use to which they are added can be achieved.
  • trace amounts numerically means 0.0005% to about 0.5% by weight, based on the total weight of the food composition.
  • preservatives examples include sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), and the like.
  • Emulsifiers that can be used include acacia gum, carboxymethylcellulose, xanthan gum, pectin and the like.
  • acidulants examples include lead acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, and the like. Such acidulant may be added so that the food composition is at an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to the purpose of enhancing taste.
  • Thickeners that can be used include suspending implements, sedimenters, gel formers, swelling agents and the like.
  • composition of the present invention can be used as a pharmaceutical composition in a specific embodiment.
  • compositions of the present invention in addition to the active ingredient, pharmaceutically acceptable carriers, excipients, and the like, oral formulations (tablets, suspensions, granules, emulsions, capsules, syrups, etc.), parenteral formulations (sterile injectable aqueous) Or oily suspensions), topical formulations (solutions, creams, ointments, gels, lotions, patches) and the like.
  • pharmaceutically acceptable means that the subject of application (prescription) does not have more toxicity (adequately less toxic) than is applicable without inhibiting the activity of the active ingredient.
  • Examples of pharmaceutically acceptable carriers include lactose, glucose, sucrose, starch (such as corn starch, potato starch, etc.), cellulose, derivatives thereof (such as sodium carboxymethyl cellulose, ethylcellulose, etc.), malt, gelatin, talc, solids Lubricants (e.g. stearic acid, magnesium stearate, etc.), calcium sulfate, vegetable oils (e.g. peanut oil, cottonseed oil, sesame oil, olive oil, etc.), polyols (e.g. propylene glycol, glycerin, etc.), alginic acid, emulsifiers (e.g. TWEENS), wetting agents (e.g.
  • Sodium lauryl sulfate Sodium lauryl sulfate
  • colorants such as sodium lauryl sulfate
  • flavoring agents such as sodium lauryl sulfate
  • tableting agents such as sodium lauryl sulfate
  • stabilizers such as sodium lauryl sulfate
  • antioxidants such as sodium lauryl sulfate
  • preservatives water, saline, phosphate buffer solutions and the like.
  • Excipients may be selected and used according to the formulation of the pharmaceutical composition of the present invention, for example, when the pharmaceutical composition of the present invention is prepared with an aqueous suspending agent, suitable excipients are sodium carboxymethyl cellulose, methyl cellulose, hydropropylmethylcellulose And suspending agents and dispersing agents such as sodium alginate and polyvinylpyrrolidone. Suitable excipients when prepared as injections include Ringer's solution, isotonic sodium chloride, and the like.
  • the pharmaceutical composition of the present invention may be administered orally or parenterally and in some cases may be administered topically.
  • the daily dosage of the pharmaceutical composition of the present invention is usually 0.001 ⁇ 150 mg / kg body weight range, it can be administered once or divided into several times. However, since the dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as the route of administration, the age, sex, weight of the patient, and the severity of the patient, the dosage may limit the scope of the present invention in any aspect. It should not be understood as.
  • the present invention can provide a composition for relieving hangover and a composition for restoring liver function.
  • Such hangover relieving composition and liver function restorative composition may be used as a food composition, especially a functional beverage or a pharmaceutical composition.
  • the leaves, stems, flowers and roots of the Acacia tree ( Robinia pseudo-acacia ) were selected and washed with water, and each was taken in a predetermined amount. Got it.
  • the leaves, stems and roots of the alder were taken out, washed, and then drained and chopped. After leaching with 70% ethanol at 80 ° C. for 5 hours, the extract was concentrated under reduced pressure to obtain alder extract of 60 Brix or higher.
  • the leaves, stems and roots of the ashes were washed, and then drained and chopped. After leaching with 70% ethanol at 80 ° C. for 5 hours, the extract was concentrated under reduced pressure to obtain more than 60 Brix ashes.
  • Each extract prepared in the reference example was mixed with honey and 100 g of the mixture in the component ratio as shown in the following [Table 1] 1,200ml of 25 ⁇ 45 °C hot spring water taken from Cheorwon, Gangwon-do and stirred for 1 hour 10 hours The low temperature aging at a temperature of 0 ⁇ 10 °C to prepare a hangover solution.
  • the hot spring water was collected at an excavation depth of 1,000m at 779-6, Guntan-ri, Galmal-eup, Cheorwon-gun, Gangwon-do, and the water temperature was 35 °C and pH was 7.3 ⁇ 8.3.
  • FIG. 1 all the water quality standards according to the provisions of Article 5 of the Drinking Water Management Act were satisfied, and various mineral components were contained.
  • hangover quenching drinks and hot spring water itself prepared in each of the preparation examples of Tables 1 and 2 had hangover quenching activities were determined through alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities. .
  • ADH alcohol dehydrogenase
  • ADH aldehyde dehydrogenase
  • the ADH fraction and the ALDH fraction were obtained from S9 rat liver homogenate (Moltox Co., Boone, Nc, USA), and the reaction mixture for ADH activity analysis was 1.5 ml of each of the above preparations or the hot water itself, 0.75 ml of 1M.

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Abstract

La présente invention concerne une composition pour effacer les abus d'alcool et une composition pour restaurer la fonction hépatique avec de l'eau de source chaude, et, plus spécifiquement, concerne une composition pour restaurer la fonction hépatique comprenant un ingrédient actif formé d'extrait d'acacia, d'extrait de sorbier d'Europe et d'extrait d'aulne ainsi que d'eau de source chaude, ou un concentré correspondant.
PCT/KR2010/002464 2009-08-28 2010-04-20 Composition pour effacer les abus d'alcool et composition pour restaurer la fonction hépatique avec de l'eau de source chaude WO2011025120A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0080376 2009-08-28
KR1020090080376A KR20110022882A (ko) 2009-08-28 2009-08-28 온천수를 이용한 숙취 해소용 조성물 및 간 기능 회복용 조성물

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WO2011025120A2 true WO2011025120A2 (fr) 2011-03-03
WO2011025120A3 WO2011025120A3 (fr) 2011-04-21

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CN108471794A (zh) * 2016-08-09 2018-08-31 南钟铉 解酒用组成物

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KR101482719B1 (ko) * 2013-06-12 2015-01-14 재단법인 금산국제인삼약초연구소 갈용, 갈근 및 마가목 추출물을 유효성분으로 함유하는 숙취해소 및 간 기능 개선용 조성물

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WO2014097259A1 (fr) * 2012-12-20 2014-06-26 Arabian German Medical Products Co. W.L.L. Composition comprenant du raphanus, du theobroma et de la passiflora pour le traitement de l'abus d'opioïdes et d'alcool
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CN108471794B (zh) * 2016-08-09 2020-05-08 南钟铉 解酒用组成物

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