WO2010122793A1 - Procédé de production d'un dérivé de pyrazine et intermédiaire pour la production - Google Patents

Procédé de production d'un dérivé de pyrazine et intermédiaire pour la production Download PDF

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Publication number
WO2010122793A1
WO2010122793A1 PCT/JP2010/002897 JP2010002897W WO2010122793A1 WO 2010122793 A1 WO2010122793 A1 WO 2010122793A1 JP 2010002897 W JP2010002897 W JP 2010002897W WO 2010122793 A1 WO2010122793 A1 WO 2010122793A1
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WO
WIPO (PCT)
Prior art keywords
alkyl group
general formula
producing
derivative according
derivative
Prior art date
Application number
PCT/JP2010/002897
Other languages
English (en)
Japanese (ja)
Inventor
雅次 織田
Original Assignee
日本農薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日本農薬株式会社 filed Critical 日本農薬株式会社
Publication of WO2010122793A1 publication Critical patent/WO2010122793A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms

Abstract

La présente invention a pour objet un nouveau procédé de production d'un dérivé de 3-halogénoalkyl-2-halogénopyrazine utile en tant qu'intermédiaire pour la production d'agents pharmaceutiques, de produits agrochimiques et autres. L'invention a pour objet spécifique un procédé de production d'un dérivé de 3-halogénoalkyl-2-halogénopyrazine représenté par la formule générale (IV), qui est caractérisé par : la réaction d'un dérivé époxy représenté par la formule générale (II) avec de la 1,2-ethylènediamine ou l'un de ses sels d'acide pour produire un dérivé de dihydropyrazinone représenté par la formule générale (I); la conversion du dérivé de dihydropyrazinone (I) en un dérivé d'hydroxypyrazine représenté par la formule générale (III) par déshydrogénation ou oxydation; et l'halogénation du dérivé d'hydroxypyrazine (III).
PCT/JP2010/002897 2009-04-23 2010-04-22 Procédé de production d'un dérivé de pyrazine et intermédiaire pour la production WO2010122793A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009104858 2009-04-23
JP2009-104858 2009-04-23

Publications (1)

Publication Number Publication Date
WO2010122793A1 true WO2010122793A1 (fr) 2010-10-28

Family

ID=43010918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/002897 WO2010122793A1 (fr) 2009-04-23 2010-04-22 Procédé de production d'un dérivé de pyrazine et intermédiaire pour la production

Country Status (1)

Country Link
WO (1) WO2010122793A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016104755A1 (fr) * 2014-12-25 2016-06-30 旭硝子株式会社 Procédé de production d'un dérivé de dihydropyrazinone

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007072999A1 (fr) * 2005-12-22 2007-06-28 Nihon Nohyaku Co., Ltd Derives pyrazinecarboxamide et agents de lutte contre les parasites les contenant
JP2009242244A (ja) * 2008-03-28 2009-10-22 Nippon Nohyaku Co Ltd ピラジン誘導体類の製造方法及びその中間体類

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007072999A1 (fr) * 2005-12-22 2007-06-28 Nihon Nohyaku Co., Ltd Derives pyrazinecarboxamide et agents de lutte contre les parasites les contenant
JP2009242244A (ja) * 2008-03-28 2009-10-22 Nippon Nohyaku Co Ltd ピラジン誘導体類の製造方法及びその中間体類

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ISHIKAWA, N. ET AL.: "Preparation of perfluoroalkylated benzoheterocyclic compounds using hexafluoro-1,2-epoxypropane", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 50, no. 8, 1977, pages 2164 - 2167 *
MASUDA, H. ET AL.: "Synthesis of alkoxy-, (alkylthio)-, phenoxy-, and (phenylthio) pyrazines and their olfactive properties", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 34, no. 2, 1986, pages 377 - 381 *
PATEL, M. ET AL.: "Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 15, 2000, pages 1729 - 1731 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016104755A1 (fr) * 2014-12-25 2016-06-30 旭硝子株式会社 Procédé de production d'un dérivé de dihydropyrazinone
CN107108528A (zh) * 2014-12-25 2017-08-29 旭硝子株式会社 二氢吡嗪酮衍生物的制造方法

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