WO2010118711A4 - Nouveaux helquats, leurs précurseurs et procédé de préparation associé - Google Patents

Nouveaux helquats, leurs précurseurs et procédé de préparation associé Download PDF

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Publication number
WO2010118711A4
WO2010118711A4 PCT/CZ2010/000047 CZ2010000047W WO2010118711A4 WO 2010118711 A4 WO2010118711 A4 WO 2010118711A4 CZ 2010000047 W CZ2010000047 W CZ 2010000047W WO 2010118711 A4 WO2010118711 A4 WO 2010118711A4
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WO
WIPO (PCT)
Prior art keywords
group
independently
nitrogen
groups
atoms
Prior art date
Application number
PCT/CZ2010/000047
Other languages
English (en)
Other versions
WO2010118711A2 (fr
WO2010118711A3 (fr
Inventor
Filip Teply
Lukás SEVERA
Louis Adriaenssens
Jan VÁVRA
Original Assignee
Ústav organické chemie a biochemie Akademie ved Ceské republiky, v.v.i.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ústav organické chemie a biochemie Akademie ved Ceské republiky, v.v.i. filed Critical Ústav organické chemie a biochemie Akademie ved Ceské republiky, v.v.i.
Publication of WO2010118711A2 publication Critical patent/WO2010118711A2/fr
Publication of WO2010118711A3 publication Critical patent/WO2010118711A3/fr
Publication of WO2010118711A4 publication Critical patent/WO2010118711A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention a pour objet de nouveaux helquats de formule générale I, leurs précurseurs de formules générales II et III et leurs procédés de préparation à partir d'un composé de formule générale IV, les symboles S12, S1`2`, T23, T2`3`, R1, R 2, X- ayant la signification définie dans la description et les revendications. Selon cette invention, il est possible, par exemple à partir d'un composé asymétrique de formule générale IV (la liaison S1,2 est différente de la liaison S1`2`) et de 10 agents d'alkylation différents, de préparer 100 helquats différents de formule générale I et 90 helquats différents sans répétition de l'agent d'alkylation. A partir du composé symétrique de formule générale IV (la liaison S1,2 est identique à la liaison S1`2`) et de 10 agents d'alkylation différents, il est possible de préparer 55 helquats différents de formule générale I et 45 helquats différents sans répétition de l'agent d'alkylation.
PCT/CZ2010/000047 2009-04-16 2010-04-14 Nouveaux helquats, leurs précurseurs et procédé de préparation associé WO2010118711A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20090237A CZ2009237A3 (cs) 2009-04-16 2009-04-16 Nové helquaty, jejich prekurzory a zpusob jejich prípravy
CZPV2009-237 2009-04-16

Publications (3)

Publication Number Publication Date
WO2010118711A2 WO2010118711A2 (fr) 2010-10-21
WO2010118711A3 WO2010118711A3 (fr) 2011-01-06
WO2010118711A4 true WO2010118711A4 (fr) 2011-03-03

Family

ID=42752964

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2010/000047 WO2010118711A2 (fr) 2009-04-16 2010-04-14 Nouveaux helquats, leurs précurseurs et procédé de préparation associé

Country Status (2)

Country Link
CZ (1) CZ2009237A3 (fr)
WO (1) WO2010118711A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304996B6 (cs) * 2013-01-17 2015-03-18 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Deriváty helquatů, jejich příprava a použití jako léčiva
US9879004B2 (en) 2013-02-07 2018-01-30 Merck Patent Gmbh Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4
US10761053B2 (en) 2014-04-23 2020-09-01 Terumo Kabushiki Kaisha Non-enzymatic electrochemical sensor for measuring analytes
CZ307163B6 (cs) * 2014-05-29 2018-02-14 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Helquaty s heteroaromatickými substituenty, jejich příprava a použití jako stabilizátory G-kvadruplexů

Also Published As

Publication number Publication date
WO2010118711A2 (fr) 2010-10-21
CZ2009237A3 (cs) 2010-10-27
WO2010118711A3 (fr) 2011-01-06

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