WO2010107069A1 - Composition ophtalmique contenant des acides aminés - Google Patents

Composition ophtalmique contenant des acides aminés Download PDF

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Publication number
WO2010107069A1
WO2010107069A1 PCT/JP2010/054571 JP2010054571W WO2010107069A1 WO 2010107069 A1 WO2010107069 A1 WO 2010107069A1 JP 2010054571 W JP2010054571 W JP 2010054571W WO 2010107069 A1 WO2010107069 A1 WO 2010107069A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
glutamine
ophthalmic composition
asparagine
arginine
Prior art date
Application number
PCT/JP2010/054571
Other languages
English (en)
Japanese (ja)
Inventor
茂 木下
千恵 外園
淳爾 羽室
明 岡野
Original Assignee
千寿製薬株式会社
味の素株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 千寿製薬株式会社, 味の素株式会社 filed Critical 千寿製薬株式会社
Priority to JP2011504870A priority Critical patent/JPWO2010107069A1/ja
Publication of WO2010107069A1 publication Critical patent/WO2010107069A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition ophtalmique qui est utile pour la prévention ou le traitement des conditions de sécheresse oculaire, notamment pour la prévention ou le traitement de conditions de sécheresse oculaire associées à de graves troubles épithéliaux. La présente invention décrit spécifiquement une composition ophtalmique qui est caractérisée par le fait qu'elle contient au moins un acide aminé choisi dans un groupe constitué par l'alanine, l'asparagine, la glutamine et l'arginine. La composition ophtalmique contient de préférence : deux ou trois acides aminés choisis parmi l'alanine, l'asparagine et la glutamine ; trois acides aminés, précisément l'arginine, l'asparagine et la glutamine ; ou deux acides aminés, précisément l'arginine et la glutamine. La présente invention concerne en outre une composition ophtalmique destinée à la prévention ou au traitement de troubles de la surface oculaire, notamment à la prévention ou au traitement de troubles de l'épithélium cornéen et conjonctival.
PCT/JP2010/054571 2009-03-17 2010-03-17 Composition ophtalmique contenant des acides aminés WO2010107069A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011504870A JPWO2010107069A1 (ja) 2009-03-17 2010-03-17 アミノ酸含有眼科用組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009065284 2009-03-17
JP2009-065284 2009-03-17

Publications (1)

Publication Number Publication Date
WO2010107069A1 true WO2010107069A1 (fr) 2010-09-23

Family

ID=42739728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/054571 WO2010107069A1 (fr) 2009-03-17 2010-03-17 Composition ophtalmique contenant des acides aminés

Country Status (2)

Country Link
JP (1) JPWO2010107069A1 (fr)
WO (1) WO2010107069A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017094506A1 (fr) * 2015-11-30 2017-06-08 ロート製薬株式会社 Composition ophtalmique
CN112516080A (zh) * 2018-01-23 2021-03-19 盛元医药广州有限公司 一种眼用药物组合物及其制备方法和应用
CN114869873A (zh) * 2022-05-05 2022-08-09 陈小鸟 谷氨酰胺在制备治疗干眼症的药物中的应用
RU2812316C2 (ru) * 2018-01-23 2024-01-29 Сэйнда Фармасьютикал Гуанчжоу Корпорейшн Офтальмологическая фармацевтическая композиция и способы ее получения и применения

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160482A (ja) * 2001-09-17 2003-06-03 Menicon Co Ltd 眼科用液剤及びコンタクトレンズ用液剤
WO2006137469A1 (fr) * 2005-06-22 2006-12-28 Ajinomoto Co., Inc. Activateur du récepteur métabotropique du glutamate
ITRM20070202A1 (it) * 2007-04-10 2008-10-11 Finchlane Ltd Soluzione per uso esterno cicatrizzante le lesioni cutanee

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4605837B2 (ja) * 1999-06-17 2011-01-05 株式会社メニコンネクト 点眼剤
JP2001261552A (ja) * 2000-03-22 2001-09-26 Chisso Corp 点眼液用保存剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160482A (ja) * 2001-09-17 2003-06-03 Menicon Co Ltd 眼科用液剤及びコンタクトレンズ用液剤
WO2006137469A1 (fr) * 2005-06-22 2006-12-28 Ajinomoto Co., Inc. Activateur du récepteur métabotropique du glutamate
ITRM20070202A1 (it) * 2007-04-10 2008-10-11 Finchlane Ltd Soluzione per uso esterno cicatrizzante le lesioni cutanee

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE BERARDINIS, E.: "The scar-producing action of amino acids in experimental corneal lesions and their influence on the metabolism of the cornea", AMERICAN JOURNAL OF OPHTHALMOLOGY, vol. 36, 1953, pages 138 - 139 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017094506A1 (fr) * 2015-11-30 2017-06-08 ロート製薬株式会社 Composition ophtalmique
JPWO2017094506A1 (ja) * 2015-11-30 2018-08-23 ロート製薬株式会社 眼科組成物
JP2019151661A (ja) * 2015-11-30 2019-09-12 ロート製薬株式会社 眼科組成物
JP7133048B2 (ja) 2015-11-30 2022-09-07 ロート製薬株式会社 眼科組成物
JP2021063133A (ja) * 2015-11-30 2021-04-22 ロート製薬株式会社 眼科組成物
EP3744316A4 (fr) * 2018-01-23 2021-12-08 Seinda Pharmaceutical Guangzhou Corporation Composition pharmaceutique ophtalmique, son procédé de préparation et son application
JP2021512172A (ja) * 2018-01-23 2021-05-13 セインダ ファーマシューティカル グアンジョウ コーポレイション 眼科的薬学的組成物、その調製方法、およびその適用
CN112516080A (zh) * 2018-01-23 2021-03-19 盛元医药广州有限公司 一种眼用药物组合物及其制备方法和应用
CN112516080B (zh) * 2018-01-23 2023-09-19 盛元医药广州有限公司 一种眼用药物组合物及其制备方法和应用
JP7418351B2 (ja) 2018-01-23 2024-01-19 セインダ ファーマシューティカル グアンジョウ コーポレイション 眼科的薬学的組成物、その調製方法、およびその適用
RU2812316C2 (ru) * 2018-01-23 2024-01-29 Сэйнда Фармасьютикал Гуанчжоу Корпорейшн Офтальмологическая фармацевтическая композиция и способы ее получения и применения
EP4279063A3 (fr) * 2018-01-23 2024-02-14 Seinda Pharmaceutical Guangzhou Corporation Composition pharmaceutique ophtalmique, son procédé de préparation et son application
CN114869873A (zh) * 2022-05-05 2022-08-09 陈小鸟 谷氨酰胺在制备治疗干眼症的药物中的应用

Also Published As

Publication number Publication date
JPWO2010107069A1 (ja) 2012-09-20

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