WO2010091815A1 - Verfahren zur herstellung von bestrahlungsmodulen - Google Patents
Verfahren zur herstellung von bestrahlungsmodulen Download PDFInfo
- Publication number
- WO2010091815A1 WO2010091815A1 PCT/EP2010/000648 EP2010000648W WO2010091815A1 WO 2010091815 A1 WO2010091815 A1 WO 2010091815A1 EP 2010000648 W EP2010000648 W EP 2010000648W WO 2010091815 A1 WO2010091815 A1 WO 2010091815A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hollow cylinder
- profiled
- cylindrical body
- tube
- irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- NFJPEKRRHIYYES-UHFFFAOYSA-N C=C1CCCC1 Chemical compound C=C1CCCC1 NFJPEKRRHIYYES-UHFFFAOYSA-N 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L11/00—Hoses, i.e. flexible pipes
- F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics
- F16L11/11—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall
- F16L11/118—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall having arrangements for particular purposes, e.g. electrically conducting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
- B01J19/123—Ultraviolet light
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/242—Tubular reactors in series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P19/00—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes
- B23P19/02—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes for connecting objects by press fit or for detaching same
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/66—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by liberation of internal stresses, e.g. shrinking of one of the parts to be joined
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/52—Joining tubular articles, bars or profiled elements
- B29C66/522—Joining tubular articles
- B29C66/5227—Joining tubular articles for forming multi-tubular articles by longitudinally joining elementary tubular articles wall-to-wall (e.g. joining the wall of a first tubular article to the wall of a second tubular article) or for forming multilayer tubular articles
- B29C66/52271—Joining tubular articles for forming multi-tubular articles by longitudinally joining elementary tubular articles wall-to-wall (e.g. joining the wall of a first tubular article to the wall of a second tubular article) or for forming multilayer tubular articles one tubular article being placed inside the other
- B29C66/52272—Joining tubular articles for forming multi-tubular articles by longitudinally joining elementary tubular articles wall-to-wall (e.g. joining the wall of a first tubular article to the wall of a second tubular article) or for forming multilayer tubular articles one tubular article being placed inside the other concentrically, e.g. for forming multilayer tubular articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/53—Joining single elements to tubular articles, hollow articles or bars
- B29C66/532—Joining single elements to the wall of tubular articles, hollow articles or bars
- B29C66/5324—Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially annular, i.e. of finite length
- B29C66/53241—Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially annular, i.e. of finite length said articles being tubular and said substantially annular single elements being of finite length relative to the infinite length of said tubular articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/74—Joining plastics material to non-plastics material
- B29C66/746—Joining plastics material to non-plastics material to inorganic materials not provided for in groups B29C66/742 - B29C66/744
- B29C66/7465—Glass
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L11/00—Hoses, i.e. flexible pipes
- F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics
- F16L11/11—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall
- F16L11/118—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall having arrangements for particular purposes, e.g. electrically conducting
- F16L11/1185—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall having arrangements for particular purposes, e.g. electrically conducting electrically conducting
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L11/00—Hoses, i.e. flexible pipes
- F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics
- F16L11/12—Hoses, i.e. flexible pipes made of rubber or flexible plastics with arrangements for particular purposes, e.g. specially profiled, with protecting layer, heated, electrically conducting
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L11/00—Hoses, i.e. flexible pipes
- F16L11/20—Double-walled hoses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00018—Construction aspects
- B01J2219/0002—Plants assembled from modules joined together
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2023/00—Tubular articles
- B29L2023/18—Pleated or corrugated hoses
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/30—Treatment of water, waste water, or sewage by irradiation
- C02F1/32—Treatment of water, waste water, or sewage by irradiation with ultraviolet light
- C02F1/325—Irradiation devices or lamp constructions
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/002—Construction details of the apparatus
- C02F2201/004—Seals, connections
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/49867—Assembling or joining with prestressing of part of skin on frame member
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/49867—Assembling or joining with prestressing of part of skin on frame member
- Y10T29/49869—Assembling or joining with prestressing of part of skin on frame member by flexing
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/4987—Elastic joining of parts
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49945—Assembling or joining by driven force fit
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/53—Means to assemble or disassemble
- Y10T29/53987—Tube, sleeve or ferrule
Definitions
- the present invention is an apparatus and a method for applying flexible, profiled hollow cylinder on cylindrical body.
- Profiled hollow cylinders which are applied to a cylindrical body, form modules which are suitable for the irradiation of fluid media with electromagnetic radiation.
- the present invention therefore also provides a process for the production of radiation modules and irradiation modules produced by means of the process according to the invention.
- a cylinder is a body bounded by two parallel, flat surfaces (ground and top surface) and a lateral surface formed by parallel straight lines. It is created by shifting a flat surface or curve along a straight line that is not in this plane.
- Cylinder is a circular cylinder. It is created by shifting a circle parallel to a straight line through the center of the circle, the line not being in the circle plane.
- a circular cylinder is limited by two parallel circular surfaces (base and top surface) and the so-called lateral surface.
- Embodiment of a cylinder understood, which is characterized in that from the base a channel parallel to the lateral surface extends to the top surface.
- a pipe is an example of a hollow cylinder.
- a flexible hollow cylinder is understood to be a hollow cylinder which can be bent and / or stretched to a certain extent. The degree of stretching and / or bending amounts to at least 1% of the length and / or the diameter of the hollow cylinder.
- An example of a flexible hollow cylinder is a hose.
- a profiled hollow cylinder is understood to mean a hollow cylinder which has a profile along its lateral surface. This profile can eg wavy or be windy. Examples of profiled hollow cylinders are corrugated hoses and corrugated pipes as well as spiral hoses and helical pipes.
- a flexible profiled hollow cylinder is characterized in that it can be stretched to some extent (at least 1% of the length and / or diameter of the hollow cylinder, preferably 5 to 20%) along its longitudinal axis.
- corrugated hoses are used for the protection and bundling of electrical or other lines and also for flexible connection to peripheral devices.
- plastic corrugated tubes are mainly used as or instead of so-called empty conduits both in outdoor areas, but above all within building walls and ceilings.
- Corrugated tubes are used as heat exchangers (for example made of stainless steel in buffer tanks or out of
- Corrugated structure serves to enlarge the surface for the best possible heat transfer.
- Corrugated pipe pieces metal bellows are used to compensate for axial offsets or to compensate for changes in length and angle.
- irradiation module a so-called irradiation module is described, which is characterized in that a helical tube is applied in a form-fitting manner via an inner support tube. This creates between the
- Support tube and the helical tube a channel helically from one end of the Spiral hose runs around the support tube to the other end of the spiral tube.
- Such a device is very well suited for the irradiation of fluid media flowing through the channel.
- one or more radiation sources are arranged in the support tube and / or the spiral tube, which preferably the medium flowing in the channel with UV radiation, particularly preferably with
- UV-C radiation Irradiate UV-C radiation.
- the irradiation leads to the reduction of microorganisms and / or viruses or to the chemical reaction in a photochemical reactor.
- the special characteristic of the channel through which it flows is an intensive, uniform cross-mixing prevailing over the entire length perpendicular to the
- the helical tube surrounds the support tube in a form-fitting manner and thus only a single channel is formed, which extends helically around the support tube. Cross flows between adjacent channel windings are to be avoided, as these would lead to a broadening of the residence time distribution.
- the production of the channel takes place in EP-A 1464342 by pulling a coiled hose onto a cylindrical support body.
- a suitable geometry of the relative to the support body in the inner diameter slightly reduced helical tube a tight, non-positive connection between the two elements is produced.
- the axial short-circuit currents otherwise caused by gaps between the channel windings and the associated widening of the residence time distribution can be prevented.
- a profiled hollow cylinder has due to its profiling of the lateral surface a number of bottlenecks (also referred to here as turns), which must be overcome when applied to a cylindrical body.
- Hollow cylinder and / or must be exercised on the body grows with the length of the hollow cylinder.
- Channel windings lead to pressure losses. By bruising individual channels can hardly prevent gaps between adjacent channel windings. The result is a poorly defined and non-reproducible irradiation device. In addition, too much friction can lead to particle abrasion. These particles are critical for various applications, such as in the pharmaceutical environment.
- WO-A 02/38502 WO-A 02/38191, WO-A 07/096057 and EP-A 1464342 described irradiation devices can be produced inexpensively and reproducibly on an industrial scale.
- the process sought should be at least partially automated. It should be easy and inexpensive to exercise. Furthermore, the task is to provide a device with which the desired method can be exercised. The sought device should be intuitive to use and also inexpensive.
- the proposed method is intended to enable the reproducible production of irradiation devices, which have well-defined channel geometries and thus the effective and reproducible results in the
- Irradiation of fluid media by means of electromagnetic radiation for example for the purpose of inactivating microorganisms and / or viruses with UV radiation.
- Hollow cylinder along the longitudinal axis to be elongated i.e., axially stretched.
- the subject of the present invention is therefore a method for applying a flexible profiled hollow cylinder to a cylindrical body, comprising at least the following steps:
- the inventive method is applicable to flexible, profiled hollow cylinder whose profiling at least partially in the form of waves or grooves, which do not extend in the direction of the longitudinal axis. Examples of such flexible, profiled hollow cylinders are shown schematically in FIG. Further profiles are conceivable.
- the elongation of the hollow cylinder means that the hollow cylinder is stretched along its longitudinal axis, so that its length increases.
- the degree of elongation is from 1% to 30%, preferably from 5% to 20%, particularly preferably from 10 to 15%, so that the length of the hollow cylinder increases by the stated percentage.
- the smallest inner diameter of the hollow cylinder which is formed by the turns / constrictions of the profiling, increases as a result of an elongation according to the invention. If elongation exceeds a threshold, the smallest diameter may decrease again.
- the threshold value depends on the material and the profiling. The threshold can easily be determined empirically.
- the optimal duration of elongation for each case can be determined empirically. Parameters which determine the optimal duration of an elongation are eg material, thickness and length of the hollow cylinder,
- the elongation of the invention in step (a) is not longer than two minutes, when the elongated hollow cylinder made of PTFE (polytetrafluoroethylene) and at room temperature (15 ° C to 25 ° C) is processed.
- PTFE polytetrafluoroethylene
- the elongation of the hollow cylinder according to the invention can be carried out by fixing the hollow cylinder at one end and gripping and stretching it at the other end.
- the hollow cylinder can be hung at one end.
- the own weight of the hollow cylinder already takes a certain lengthening. By applying weights and / or pulling on the other end, the elongation can be increased.
- the cylindrical body can be introduced from above or below in the elongated hollow cylinder.
- the elongation takes place by grasping the hollow cylinder at at least one point, preferably at least two points. Preferred locations for grasping the
- Hollow cylinder are the two ends.
- one socket (the first) can be held while the other socket is removed from the first.
- both sockets move away from each other.
- the socket of the hollow cylinders takes place at several points along the hollow cylinder.
- the socket locations are preferably distributed uniformly over the length of the hollow cylinder.
- Preferably are located at the two ends of the hollow cylinder sockets.
- the optimum number of sockets depends on the length, shape and material of the hollow cylinder and can be determined empirically.
- the distance between two adjacent adjustment points is 300 mm to 500 mm when using a PTFE spiral hose with a diameter of 5 to 20 cm as a profiled hollow cylinder.
- Step (b) of the method according to the invention it is irrelevant whether the body is pushed into the hollow cylinder or the hollow cylinder is pulled or pushed onto the body, or whether a combination of movements and forces occurs.
- a corresponding device ensures that body and hollow cylinder reach each other in a predetermined position (example s.u.). If in the following it is said that the hollow cylinder is pulled or pushed onto the body or the body is pushed or pulled into the hollow cylinder, this always means a force and a resulting relative movement between the hollow cylinder and the body meant the hollow cylinder and body in one brings predetermined position to each other.
- step (b) is performed using a so-called centering device or introducer.
- the centering device or insertion aid is an attachment which is attached to the end of the cylindrical body with which the body is introduced into the hollow cylinder.
- the body to be introduced has sharp edges which, when the body is introduced into the hollow cylinder, can lead to shavings and / or scratches and / or cuts on the turns / constrictions of the profiling of the hollow cylinder.
- the elongated hollow cylinder can not be aligned in all cases along its entire length along its longitudinal axis. In a horizontal position of the elongated hollow cylinder of the flexible hollow cylinder between two positions, if necessary, a little down.
- the cylindrical body to be introduced could hit against turns / bottlenecks and cause damage. This is effectively prevented by the use of a centering device or insertion aid, which is preferably conical and introduces the Body leads.
- An example of a centering device or insertion aid is given in FIG.
- step (c) the force to elongate the hollow cylinder is released, so that the hollow cylinder relaxes and decreases in length.
- Hollow cylinder decreases by this relaxation again and the hollow cylinder encloses the cylindrical body.
- Step (c) takes place as evenly as possible over the entire length of the hollow cylinder, so that no stresses arise within the profiled hollow cylinder.
- the hollow cylinder should be uniformly and uniformly applied to the cylindrical body. This is done particularly effectively using so-called Matritzen, which lead the relaxation and facilitate the adjustment between the hollow cylinder and the cylindrical body.
- the matrices have a profile that corresponds to the "negative" of the hollow cylinder profile, thereby ensuring that a maximum contact surface is created and the forces for elongation and adjustment can be uniformly introduced into the profiled hollow cylinder.
- the erf ⁇ ndungshiele method in a modified form is also suitable for introducing a flexible, profiled hollow cylinder in another hollow cylinder.
- Hollow cylinder not only increases its smallest inner diameter, but surprisingly also its largest outer diameter. If a flexible, profiled hollow cylinder to be introduced into a hollow cylinder whose inner diameter is smaller than the largest outer diameter of the profiled
- An irradiation device is understood to mean a device through which a fluid medium flows, the medium being exposed to electromagnetic radiation.
- UV radiation such an irradiation device can be used, for example, for the reduction of microorganisms and / or viruses in fluid media.
- IR radiation such an irradiation device can be used eg for heating a fluid medium.
- Other uses are conceivable, such as reactors for photochemically activated and / or photochemical processes.
- a helical tube is used as the flexible, profiled hollow cylinder.
- the helical tube is preferably made of a plastic, e.g. PTFE
- a tube transparent to electromagnetic radiation is preferably used.
- a quartz glass tube is used, which is transparent to UV radiation.
- the inventive method is particularly suitable for the production of such irradiation devices - hereinafter also called irradiation modules, which are characterized in that a helical tube is mounted on a support tube so that there is an interference fit between the helical tube and the support tube. Under press fit is understood that the smallest inner diameter of the reversible tube in the force-free state is smaller than the outer diameter of the cylindrical body.
- Elongation is the smallest inner diameter of the reversible tube enlarged and reaches a value that is greater than the outer diameter of the support tube.
- Inner diameter of the hose and the turns of the hose enclose the quartz glass tube in a form-fitting and uniform manner. Due to the interference fit, the windings exert a pressure on the quartz glass, so that the hose can not slip off the quartz glass tube. Furthermore, when using the irradiation modules, there is no short-circuit flow between adjacent helical coils. The result is a reproducible channel, which has a uniform cross section over its length and extends helically around the support tube.
- the subject of the present invention is thus also a process for the production of irradiation modules.
- irradiation modules which have been produced by means of the inventive method, the subject of the present invention.
- the radiation modules according to the invention can be e.g. for the irradiation of fluid media for the purpose of sterilization and / or virus inactivation.
- Sterilization or microbial reduction in fluid media is an important step in many processes. Contamination with active, ie reproducible, biological material such as microorganisms or viruses often poses a threat to product safety, which must be effectively counteracted.
- the germ reduction by inactivation with ultraviolet radiation has long been known and is widely practiced. Examples include surface disinfection as well as the treatment of liquid media such as drinking and wastewater.
- An essential technical challenge is given if, in addition to the microorganisms to be inactivated, valuable substances are also contained which, to a certain extent, can also be damaged by the radiation.
- Such requirements are typical for sterilization in the field of food and bio-pharmaceutical liquids, such as protein solutions. Additional difficulties arise when the turbidity of the processed liquid in the range of UV-C radiation high and thus the penetration of the inactivating Radiation is low.
- Such applications call for technical systems which, despite the high turbidity, can achieve homogeneous irradiation, that is to say a narrow dose distribution.
- a certain residence time in the irradiation zone equivalent to irradiation time, is additionally to be provided here.
- the system-specific residence time distribution also leads to a broad, that is to say inhomogeneous, dose distribution in the liquid.
- the radiation module according to the invention for the irradiation of fluids with electromagnetic radiation comprises a UV-transparent tube (cylindrical body) for receiving a centrally arranged, elongate radiation source and a spiral tube (profiled hollow cylinder) applied to the tube, such that between the turning tube and tube depending on Profiling one or more helical channels arise in which a processed fluid, during the residence time in the irradiation zone, can be irradiated.
- a helical channel forces the fluid flowing through into a helical one
- the special feature of the flow-through channel is an intensive, over the entire length prevailing uniform (caused by so-called Dean vortex) cross-mixing perpendicular to the main direction of the
- Such a channel particularly preferably has a rectangular (preferably with rounded corners), trapezoidal or semicircular cross-sectional profile.
- a channel has a depth of 1 to 100 mm, preferably of 2 to 50 mm, and an average width of 1 to 200 mm, preferably of 2 to 50 mm, in the cross-sectional profile.
- Very particular preference is given to a design of the profiled hollow cylinder in which the profiling in a single inside along the lateral surface helically running channel, which has a pitch of 2 to 20 ° (pitch angle), preferably from 4 to 10 °.
- the material of the tube, through which the irradiation of the liquid takes place, should be largely radiolucent.
- Suitable materials are, depending on the wavelength range of the electromagnetic radiation, for example, glass or plastics.
- the material that forms the channel and is not irradiated should be dimensionally stable in particular.
- Suitable materials are, for example, metallic materials, plastics, ceramics, glass or composite materials. Should this
- Material to be at least largely transparent to the electromagnetic radiation used so a supplementary or alternative irradiation can also be done by this component from the outside.
- Another embodiment may be a reflective coating on the inside of the profiled hollow cylinder, so that it leads to a reflection of the radiation and thus to an intensification of the
- the irradiation module according to the invention is produced by applying a spiral tube made of PTFE onto a support tube permeable to UV rays, wherein the smallest inner diameter of the spiral tube, given by the inner turns, is slightly smaller than the outer diameter of the support tube.
- slightly smaller it is understood that the smallest inner diameter of the helical tube by 0.01% to 5%, preferably by 0.1% to 3% smaller than the outer diameter of the support tube.
- Pressure losses can easily be applied to the corrugated hose shrink tube improve the pressure stability.
- the radiation input takes place via an elongated radiation source introduced centrally into the support tube or from the outside with radiation sources arranged around the helical tube.
- irradiation takes place by means of a radiation source mounted inside the support tube.
- the support tube is preferably designed for UV-C treatment as permeable to UV-C rays quartz tube. Since it is difficult to clean the channels because of their poor accessibility, in a preferred embodiment the irradiation modules according to the invention are designed as disposable elements which are packed sterile or with low germs. Disposable systems are particularly popular in the biopharmaceutical industry, as the use of disposable systems saves complex cleaning validations. The requirements of such disposable systems are that they can be produced inexpensively and have a reproducible quality. The quality refers in particular to constant dimensioning and consistent
- the irradiation modules according to the invention fulfill these requirements because the method according to the invention for the production of the irradiation modules provides reproducible results, can be automated and thus be carried out on an industrial scale, as well as inexpensive and manages without lubricant.
- the irradiation modules according to the invention furthermore have at least two connections for introducing and exporting a fluid into the helical irradiation space. Examples of how a helical tube can be provided with connections on a support body can be found in EP 1464342 A1.
- the subject of the present invention is also an apparatus for applying flexible profiled hollow cylinders to cylindrical bodies.
- the device according to the invention has means for mounting a flexible, profiled hollow cylinder at one or more points, via means for elongation of the wooden cylinder and means for introducing the body in the profiled
- the socket of a hollow cylinder is preferably carried out in at least two places.
- the means for mounting the hollow cylinder (socket elements) hold a hollow cylinder preferably at the ends.
- further socket elements are preferably uniform over the length of the hollow cylinder
- All socket elements or all socket elements except one are designed to be movable, so that they can be moved against each other after grasping the hollow cylinder and so the hollow cylinder can be stretched (lengthened) along its longitudinal axis.
- the movement of the socket elements takes place e.g. by stepper motors or the like.
- the device according to the invention has position indicators which allow the position of each socket element to be determined so that the elongation and / or the adjustment and / or the relaxation proceed in a regulated manner.
- the means for introducing the cylindrical body in the profiled hollow cylinder for example, consist of a motor-driven push rod, which introduces the example mounted on support elements body in the hollow cylinder.
- the device according to the invention further comprises means for temperature control in order to ensure constant process conditions. Furthermore, it may be advantageous to heat the profiled hollow cylinder before elongation and / or relaxation, for example, to increase its elasticity and thus to prevent damage due to elongation.
- the device according to the invention further comprises means for adjustment between the hollow cylinder and the cylindrical body.
- means for adjustment between the hollow cylinder and the cylindrical body An example is shown in Figure 6c.
- the socket elements and / or means for adjustment at the contact point to the hollow cylinder also have a profiled contour corresponding to the negative contour of the profiled hollow cylinder.
- the width of a receptacle should be at least one, preferably two to ten, more preferably two to five profile turns.
- the device according to the invention further comprises means for increasing the internal pressure within the profiled hollow cylinder in order to widen the smallest inner diameter of the profiled hollow cylinder.
- the pressure increase can be carried out in support of the elongation.
- Further features of the device according to the invention are means for controlling the elongation and / or the adjustment of the profiled hollow cylinder and / or the introduction of the cylindrical body in the elongate hollow cylinder.
- Figure 1 shows schematically four examples of profiled hollow cylinder in the side view, which have different profiles: helical turns (a, c) and wave-shaped windings (b, d). All hollow cylinders shown have a profiling, which consists in the form of waves or grooves, which do not extend in the direction of the longitudinal axis.
- Figure 2 shows schematically a profiled hollow cylinder (1) which is applied to a cylindrical body (2).
- the profiling (3) consists of parallel annular turns along the lateral surface of the hollow cylinder.
- FIG. 3 schematically shows an irradiation module according to the invention, comprising a helical tube as a profiled hollow cylinder (1) and a cylindrical support tube (2): (a) in side elevation, (b) in cross-section from the side.
- the helical profiling (3) in combination with the interference fit, results in a channel (20) helically running around the support tube.
- Windings of the channel are prevented by the press fit.
- WO2007 / 096057 examples are described how the channel can be provided with connections for the supply and removal of fluid media.
- Figure 4 shows schematically the inventive method for applying elastic, profiled hollow cylinder (1) on a cylindrical body (2).
- the hollow cylinder is first elongated (indicated by the white horizontal arrows).
- the smallest inner diameter Di of the hollow cylinder is in the stress-free state preferably slightly smaller than or equal to the outer diameter D A of the cylindrical body. Due to the elongation, the smallest inner diameter increases to a value dj which is greater than the outer diameter D A (FIG. 4b).
- Fig. 4 (b) it is shown how the cylindrical body can be easily introduced into the elongated hollow cylinder (indicated by the thick black arrow).
- Fig. 4 (c) the hollow cylinder is relaxed (indicated by the white arrows) and closes in Fig. 4 (d) form fit around the cylindrical body.
- the process of applying should to complete the material of the profiled hollow cylinder, especially when using PTFE, be completed in a few minutes, preferably well below a minute to permanent
- Fig. 5 shows schematically an example of a centering device or insertion aid to the introduction of the cylindrical body in the elongated
- the cylindrical body (2) is a glass tube. On this glass tube is the
- a rubber ring (81) ensures that the
- the centering device is shown in Fig. 5 (a) from the side and in Fig. 5 (b) from the glass tube side facing.
- Fig. 6a shows schematically an example of an inventive device for applying a profiled hollow cylinder (1) on a cylindrical body (2) from the side.
- the cylindrical body is designed in the present example as a tube.
- the device comprises four supports (40) for holding and guiding the tube, a push rod (60) with a conical tip (65) for inserting the tube into the hollow cylinder and three holding elements (50a, 50b, 50c).
- the socket member (50c) is held while the socket members (50a) and (50b) are movable and moved away from the socket member (50c) by a drive unit while stretching the hollow cylinder.
- the socket element (50a) must move twice as fast from the element (50c) as the socket element (50b).
- the socket element (50a) must be replaced at each step that the socket element (50b) of
- Element (50c) moves two steps in the same direction. This will indicated by the different long white arrows above the socket elements. The same applies to relaxation.
- Fig. 6b shows schematically a support (40) of Fig. 6a from the front.
- Fig. 6c shows schematically and by way of example two different types of socket elements (50d, 50e) in cross section.
- Socket element (5Oe) serves the socket of a profiled hollow cylinder (1) at one of its ends. It comprises a ring (52) with a conical guide for engagement in the hollow cylinder and a further ring (53). The bead at the end of the profiled hollow cylinder is interposed between the rings (52) and (53) e.g. clamped by means of a screw connection (not shown here).
- the socket element (50d) serves to support a profiled hollow cylinder between its ends. It has a contour which corresponds to the negative profile of the hollow cylinder. The contour serves to receive and fix the
- Hollow cylinder and allows next to both the adjustment between the hollow cylinder and body introduced as well as the uniform relaxation of the elongated hollow cylinder.
- Fig. 6d shows schematically the socket element (50d) from the front. It is also referred to as a die in the above description. It consists of two semicircular elements connected by a hinge. In Fig. 6d (I) the element is open and can receive a hollow cylinder. In Fig. 6d (II) the element is closed. The open ends of the semicircular elements may e.g. be connected by screw
- Fig. 7 shows schematically how the interior of the profiled hollow cylinder can be set under an increased pressure p ⁇ , so that the insertion of the tube is additionally facilitated. This design can be sufficient alone To cause expansion of the inner diameter of the profiled hollow cylinder or in combination with an elongation of the profiled hollow cylinder.
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- General Health & Medical Sciences (AREA)
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- Toxicology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Materials For Medical Uses (AREA)
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Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK10702626.2T DK2396582T3 (en) | 2009-02-16 | 2010-02-03 | PROCEDURE FOR MANUFACTURING IRRATION MODULES |
| CN201080007937.1A CN102317667B (zh) | 2009-02-16 | 2010-02-03 | 制造辐射模块的方法 |
| JP2011549469A JP5603350B2 (ja) | 2009-02-16 | 2010-02-03 | 照射モジュールを製造する方法 |
| PL10702626T PL2396582T3 (pl) | 2009-02-16 | 2010-02-03 | Sposób wytwarzania modułów radiacyjnych |
| EP10702626.2A EP2396582B1 (de) | 2009-02-16 | 2010-02-03 | Verfahren zur herstellung von bestrahlungsmodulen |
| AU2010213199A AU2010213199B2 (en) | 2009-02-16 | 2010-02-03 | Method for producing radiation modules |
| US13/201,313 US8869371B2 (en) | 2009-02-16 | 2010-02-03 | Method for producing radiation modules |
| ES10702626.2T ES2691715T3 (es) | 2009-02-16 | 2010-02-03 | Procedimiento para la fabricación de módulos de irradiación |
| CA2752450A CA2752450C (en) | 2009-02-16 | 2010-02-03 | Method for producing radiation modules |
| US14/337,737 US9199347B2 (en) | 2009-02-16 | 2014-07-22 | Device for mounting flexible, profiled hollow cylinders unto cylindrical elements |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009009108.4 | 2009-02-16 | ||
| DE102009009108A DE102009009108B3 (de) | 2009-02-16 | 2009-02-16 | Verfahren und Vorrichtung zum Verbinden eines flexiblen profilierten Hohlzylinders mit einem zylinderförmigen Körper, sowie danach hergestellte Bestrahlungsmodule |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/201,313 A-371-Of-International US8869371B2 (en) | 2009-02-16 | 2010-02-03 | Method for producing radiation modules |
| US14/337,737 Division US9199347B2 (en) | 2009-02-16 | 2014-07-22 | Device for mounting flexible, profiled hollow cylinders unto cylindrical elements |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2010091815A1 true WO2010091815A1 (de) | 2010-08-19 |
Family
ID=42034577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2010/000648 Ceased WO2010091815A1 (de) | 2009-02-16 | 2010-02-03 | Verfahren zur herstellung von bestrahlungsmodulen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8869371B2 (enExample) |
| EP (1) | EP2396582B1 (enExample) |
| JP (1) | JP5603350B2 (enExample) |
| KR (1) | KR101643019B1 (enExample) |
| CN (1) | CN102317667B (enExample) |
| AU (1) | AU2010213199B2 (enExample) |
| CA (1) | CA2752450C (enExample) |
| DE (1) | DE102009009108B3 (enExample) |
| DK (1) | DK2396582T3 (enExample) |
| ES (1) | ES2691715T3 (enExample) |
| PL (1) | PL2396582T3 (enExample) |
| WO (1) | WO2010091815A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013158717A (ja) * | 2012-02-06 | 2013-08-19 | Chiyoda Kohan Co Ltd | 紫外線照射装置 |
| US9499415B2 (en) | 2014-08-14 | 2016-11-22 | Chiyoda Kohan Co., Ltd | Ultraviolet irradiation apparatus |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009009108B3 (de) * | 2009-02-16 | 2010-06-17 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zum Verbinden eines flexiblen profilierten Hohlzylinders mit einem zylinderförmigen Körper, sowie danach hergestellte Bestrahlungsmodule |
| CA2872103A1 (en) * | 2013-11-22 | 2015-05-22 | Schluter Systems L.P. | In-floor heating apparatuses and associated methods |
| DE102017202944A1 (de) | 2017-02-23 | 2018-08-23 | Fränkische Industrial Pipes GmbH & Co. KG | Schlauchkombination mit elektromagnetischer Abschirmung, Schlauch mit elektromagnetischer Abschirmung und Verwendung einer derartigen Schlauchkombination bzw. eines derartigen Schlauchs |
| CN107448693A (zh) * | 2017-09-30 | 2017-12-08 | 广西金盛科技发展有限公司 | Hdpe增强双壁波纹管 |
| JP7497685B2 (ja) * | 2021-01-19 | 2024-06-11 | 株式会社オンダ製作所 | 被覆付パイプの製造装置及び製造方法 |
| CA3225460A1 (en) * | 2021-06-25 | 2022-12-29 | Novolabs Limited | Liquid treatment method and apparatus |
| CN114674464B (zh) * | 2022-01-05 | 2023-09-22 | 岭澳核电有限公司 | 用于辐照松弛检测的内应力测量装置和方法 |
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- 2010-02-03 PL PL10702626T patent/PL2396582T3/pl unknown
- 2010-02-03 KR KR1020117018825A patent/KR101643019B1/ko active Active
- 2010-02-03 WO PCT/EP2010/000648 patent/WO2010091815A1/de not_active Ceased
- 2010-02-03 CA CA2752450A patent/CA2752450C/en active Active
- 2010-02-03 US US13/201,313 patent/US8869371B2/en active Active
- 2010-02-03 CN CN201080007937.1A patent/CN102317667B/zh active Active
- 2010-02-03 EP EP10702626.2A patent/EP2396582B1/de active Active
- 2010-02-03 ES ES10702626.2T patent/ES2691715T3/es active Active
- 2010-02-03 AU AU2010213199A patent/AU2010213199B2/en active Active
- 2010-02-03 DK DK10702626.2T patent/DK2396582T3/en active
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| US9499415B2 (en) | 2014-08-14 | 2016-11-22 | Chiyoda Kohan Co., Ltd | Ultraviolet irradiation apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102317667A (zh) | 2012-01-11 |
| AU2010213199A1 (en) | 2011-08-25 |
| JP2012518126A (ja) | 2012-08-09 |
| KR101643019B1 (ko) | 2016-07-26 |
| DK2396582T3 (en) | 2018-11-12 |
| US8869371B2 (en) | 2014-10-28 |
| AU2010213199B2 (en) | 2016-03-31 |
| US9199347B2 (en) | 2015-12-01 |
| DE102009009108B3 (de) | 2010-06-17 |
| CA2752450C (en) | 2017-02-28 |
| ES2691715T3 (es) | 2018-11-28 |
| CN102317667B (zh) | 2014-08-20 |
| US20110314655A1 (en) | 2011-12-29 |
| PL2396582T3 (pl) | 2018-12-31 |
| KR20110126619A (ko) | 2011-11-23 |
| EP2396582B1 (de) | 2018-07-18 |
| EP2396582A1 (de) | 2011-12-21 |
| US20140373328A1 (en) | 2014-12-25 |
| CA2752450A1 (en) | 2010-08-19 |
| JP5603350B2 (ja) | 2014-10-08 |
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