WO2010087137A1 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
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- WO2010087137A1 WO2010087137A1 PCT/JP2010/000346 JP2010000346W WO2010087137A1 WO 2010087137 A1 WO2010087137 A1 WO 2010087137A1 JP 2010000346 W JP2010000346 W JP 2010000346W WO 2010087137 A1 WO2010087137 A1 WO 2010087137A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N2035/1076—Multiple transfer devices plurality or independently movable heads
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
- G01N2035/1086—Cylindrical, e.g. variable angle
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Definitions
- the present invention relates to an automatic analyzer for performing qualitative and quantitative analysis of biological samples such as blood and urine, and more particularly to an automatic analyzer having a sample dilution mechanism.
- Automatic analyzers are widely known in the field of clinical testing.
- the sampling mechanism for samples, reagents, and pretreatment liquids used in this analysis has been divided into samples, specimens, reagents, and pretreatment liquids.
- the aspiration and dispensing positions are fixed regardless of the contents of the analysis request. It has been done.
- the pretreatment of the sample is to prepare a state where it can be analyzed by mixing with a pretreatment liquid in advance before analysis.
- the amount of reagent used for the reaction can be reduced by diluting the specimen with the pretreatment liquid and lowering the concentration.
- Patent Documents 1 to 4 describe automatic analyzers equipped with a pretreatment disk for dispensing such a pretreatment liquid.
- JP-A-8-101216 Japanese Patent Laid-Open No. 7-098320 JP-A-5-080059 Japanese Patent Laid-Open No. 3-25368
- An automatic analyzer having a conventional sample pretreatment function has been proposed in which a sample to be measured is processed by the pretreatment unit and then dispensed into the analysis unit for analysis.
- a sample to be measured is processed by the pretreatment unit and then dispensed into the analysis unit for analysis.
- all samples are transported to the analysis unit via the pre-processing unit. Therefore, when analyzing a sample without pretreatment, a unit for pretreatment is not required, and a loss occurs in terms of cost and installation space.
- pretreatment a minimum amount of sample is required to react with the pretreatment liquid, and there is a concern about the influence of the sample remaining in the pretreatment unit on the analysis result.
- the present invention comprises the following.
- the present invention constitutes a sample sampling mechanism having a function capable of accessing a plurality of dispensing positions without fixing the positions for aspirating and dispensing the specimens in an automatic analyzer having an analysis unit and a preprocessing unit.
- one or more sample sampling mechanisms 1 for aspirating a sample without pretreatment from the sample transport unit and dispensing it to the pretreatment unit and one or more samples for aspirating the sample from the pretreatment unit and dispensing it to the analysis unit
- the sample sampling mechanism 2 is provided with a function of sucking a sample without pretreatment from the sample transport unit and dispensing it to the analysis unit, thereby analyzing the sample with and without pretreatment. Dispensing into can be realized.
- the present invention it is possible to dispense a sample with or without sample pretreatment to an analysis unit according to an analysis request item in an automatic analyzer.
- samples with and without pretreatment are dispensed by one sampling mechanism, whereas when the number of samples is large, samples with and without pretreatment by two or more sampling mechanisms Can be dispensed.
- the amount of the original sample can be minimized, and the influence of the sample remaining in the preprocessing unit on the analysis result can be ignored.
- the reaction with the reagent is performed directly without changing the concentration of the specimen, the analysis result can be easily digitized, and the sensitivity of the measuring instrument need not be increased.
- Specimen sampling mechanism 1 to 4 are examples of a device configuration diagram having a dispensing function according to the present invention.
- Specimen sampling mechanism 1 Specimen sampling mechanism 2, Specimen input part 3, Specimen transport part 4, Specimen aspiration position 5, Specimen aspiration position 6, Specimen storage part 7, Pretreatment part 8, Analysis part 9, Reagent 10, Reagent 11,
- the reagent sampling mechanism 12 and the reagent sampling mechanism 13 are configured.
- the flow of analysis using the automatic analyzer according to the present invention will be described in four types.
- Type 1 ( Figure 1): First, the operator installs the specimen to be examined in the specimen insertion unit 3. At this time, the specimen enters a state of waiting for analysis.
- the sample passes through the sample transport unit 4 and stops at the sample suction position 5.
- the sample sampling mechanism 1 sucks the sample and dispenses it to the preprocessing unit 8.
- the sample sampling mechanism 1 sucks the sample from the preprocessing unit 8 and dispenses it to the analysis unit 9.
- the reagent 10 and the reagent 11 are dispensed to the analysis unit 9 by the reagent sampling mechanism 12 and the reagent sampling mechanism 13, mixed with the sample, and reacted to obtain an analysis result.
- Type 1 The advantages of Type 1 are described below.
- the sample sampling mechanism 1 moves the sample from the sample transport unit 4 through the preprocessing unit 8 to the analysis unit 9.
- a sample with pretreatment can be dispensed to the analysis unit 9 by one sampling mechanism. Therefore, since the operation of the sample sampling mechanism 2 can be omitted, simplification, cost reduction, and space saving are possible. If the number of samples is smaller than the above and analysis is performed with sample pretreatment, it is desirable to use this type.
- Type 2 Similar to Type 1, the sample installed in the sample insertion unit 3 passes through the sample transport unit 4 and stops at the sample aspiration position 5. At this position, the sample sampling mechanism 1 sucks the sample, passes through the preprocessing unit 8, and dispenses it to the analysis unit 9. By this operation, it is possible to dispense a sample without pretreatment to the analysis unit 9. Thereafter, the reagent 10 and the reagent 11 are dispensed to the analysis unit 9 by the reagent sampling mechanism 12 and the reagent sampling mechanism 13, mixed with the sample, and reacted to obtain an analysis result.
- Type 2 The advantages of Type 2 are described below.
- the sample sampling mechanism 1 moves the sample from the sample transport unit 4 through the preprocessing unit 8 to the analysis unit 9.
- a sample without pretreatment can be dispensed to the analysis unit 9 by one sampling mechanism. Therefore, since the operation of the sample sampling mechanism 2 can be omitted, simplification, cost reduction, and space saving are possible. If the number of specimens is less than the above and analysis is performed without specimen pretreatment, it is desirable to use this type.
- Type 3 Similar to types 1 and 2, the sample installed in the sample input unit 3 passes through the sample transport unit 4 and stops at the sample aspiration position 6. At this position, the sample sampling mechanism 2 sucks the sample and dispenses it to the preprocessing unit 8. After processing by the preprocessing unit 8, the sample sampling mechanism 1 sucks the sample from the preprocessing unit 8 and dispenses it to the analysis unit 9. Thereafter, the reagent 10 and the reagent 11 are dispensed to the analysis unit 9 by the reagent sampling mechanism 12 and the reagent sampling mechanism 13, mixed with the sample, and reacted to obtain an analysis result.
- Type 3 The advantages of Type 3 are described below.
- the sample sampling mechanism 2 moves the sample from the sample transport unit 4 to the preprocessing unit 8. Further, the sample sampling mechanism 1 moves the sample from the preprocessing unit 8 to the analysis unit 9.
- the sample sampling mechanism 2 analyzes the sample with preprocessing by performing the operation of transporting the sample from the sample transport unit 4 to the preprocessing unit 8 and the sample sampling mechanism 1 from the preprocessing unit 8 to the analysis unit 9. Can be dispensed into part 9. Accordingly, since the two sampling mechanisms operate in conjunction with each other, the dispensing cycle to the analysis unit 9 is shortened and the processing capability is improved as compared with Type 1.
- the mechanism for sampling the specimen with pretreatment and the mechanism for sampling the specimen without pretreatment are separately driven independently, the influence of the specimen remaining by the sampling mechanism can be ignored.
- the number of specimens is larger than the above and analysis is performed with specimen pretreatment, it is desirable to use this type.
- Type 4 ( Figure 4): The sample installed in the sample insertion unit 3 passes through the sample transport unit 4 and stops at the sample aspiration positions 5 and 6. At these positions, the sample sampling mechanisms 1 and 2 aspirate the sample and dispense it to the preprocessing unit 8. After processing by the preprocessing unit 8, the sample sampling mechanism 1 sucks the sample from the preprocessing unit 8 and dispenses it to the analysis unit 9. Thereafter, the reagent 10 and the reagent 11 are dispensed to the analysis unit 9 by the reagent sampling mechanism 12 and the reagent sampling mechanism 13, mixed with the sample, and reacted to obtain an analysis result.
- Type 4 sample movement from the sample transport unit 4 to the preprocessing unit 8 is performed by the sample sampling mechanism 1 and the sample sampling mechanism 2. Further, the sample sampling mechanism 1 moves the sample from the preprocessing unit 8 to the analysis unit 9. In this operation, the sample sampling mechanism 1 and the sample sampling mechanism 2 simultaneously carry the sample from the sample transport unit 4 to the preprocessing unit 8 and the sample sampling mechanism 1 carries the sample from the preprocessing unit 8 to the analysis unit 9. The processed sample can be dispensed to the analysis unit 9. Therefore, since two sampling mechanisms operate simultaneously, the dispensing cycle to the pre-processing unit 8 and the analysis unit 9 is shortened compared to the type 3, and the processing capability is improved. In particular, since the transport path to the preprocessing unit 8 is a two-system path, efficiency increases when the number of types of preprocessing such as dilution and mixing increases.
- the above-described four types of operation are possible.
- An operator using the automatic analyzer having this configuration can select whether or not the sample is preprocessed when requesting an analysis item.
- the apparatus determines which of the types 1 to 4 is to be operated, and is driven with the operation with the highest efficiency.
- the arrangement can be optimized and the space can be saved.
Abstract
Description
最初にオペレータは、検査する検体を検体投入部3へ設置する。この時、検体は分析待ち状態となる。分析を開始すると検体は検体搬送部4を通って検体吸引位置5に停止する。この位置で検体サンプリング機構1は検体を吸引して前処理部8へ分注する。前処理部8で処理後、検体サンプリング機構1は前処理部8から検体を吸引して分析部9へ分注する。この動作により前処理を行った検体を分析部9へ分注することが可能となる。その後、試薬10と試薬11を試薬サンプリング機構12と試薬サンプリング機構13によって分析部9へ分注して検体と混合し、反応させて分析結果を得る。
タイプ1と同様に検体投入部3へ設置された検体は、検体搬送部4を通って検体吸引位置5に停止する。この位置で検体サンプリング機構1は検体を吸引して前処理部8を通過後、分析部9へ分注する。この動作により前処理なしの検体を分析部9へ分注することが可能となる。その後、試薬10と試薬11を試薬サンプリング機構12と試薬サンプリング機構13によって分析部9へ分注して検体と混合し、反応させて分析結果を得る。
タイプ1,2と同様に検体投入部3へ設置された検体は、検体搬送部4を通って検体吸引位置6に停止する。この位置で検体サンプリング機構2は検体を吸引して前処理部8へ分注する。前処理部8で処理後、検体サンプリング機構1は前処理部8から検体を吸引し、分析部9へ分注する。その後、試薬10と試薬11を試薬サンプリング機構12と試薬サンプリング機構13によって分析部9へ分注して検体と混合し、反応させて分析結果を得る。
検体投入部3へ設置された検体は、検体搬送部4を通って検体吸引位置5および6に停止する。これらの位置で検体サンプリング機構1および2は検体を吸引して前処理部8へ分注する。前処理部8で処理を行った後、検体サンプリング機構1は前処理部8から検体を吸引し分析部9へ分注する。その後、試薬10と試薬11を試薬サンプリング機構12と試薬サンプリング機構13によって分析部9へ分注して検体と混合し、反応させて分析結果を得る。
3 検体投入部
4 検体搬送部
5,6 検体吸引位置
7 検体収納部
8 前処理部
9 分析部
10,11 試薬
12,13 試薬サンプリング機構
Claims (6)
- 試料を収容する検体容器と、該検体容器を保持する検体容器保持機構と、該検体容器から分注した試料に前処理液を加える前処理容器と、該前処理容器を保持する前処理容器保持機構と、試料と試薬を混合する反応容器と、該反応容器を保持する反応容器保持機構とを備えた自動分析装置であって、前記検体容器保持機構に保持された検体容器と、前記前処理容器保持機構に保持された前処理容器の双方から検体を前記反応容器保持機構に保持された反応容器に分注可能な第1の検体分注機構とを備えたことを特徴とする自動分析装置。
- 請求項1記載の自動分析装置において、
前記前処理容器保持機構は、前記検体容器保持機構と、前記反応容器保持機構に挟まれた位置に設けられていることを特徴とする自動分析装置。 - 請求項2記載の自動分析装置において、
前記第1の検体分注機構の他に、更に、前記検体容器保持機構に保持された検体容器から、前記前処理容器保持機構に保持された前処理容器に試料を分注可能な第2の検体分注機構を備えたことを特徴とする自動分析装置。 - 請求項3記載の自動分析装置において、
前記第1の検体分注機構と前記第2の検体分注機構が前記検体容器保持機構に保持された検体容器から試料を分注する位置が限定されないことを特徴とする自動分析装置。 - 請求項1~4のいずれかに記載の自動分析装置において、
検体容器保持機構は検体ラックであることを特徴とする自動分析装置。 - 請求項1~4のいずれかに記載の自動分析装置において、
前記前処理液は希釈液であることを特徴とする自動分析装置。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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DE112010000784T DE112010000784B4 (de) | 2009-01-29 | 2010-01-22 | Automatischer Analysator |
JP2010548405A JP5452507B2 (ja) | 2009-01-29 | 2010-01-22 | 自動分析装置 |
US13/145,801 US8278108B2 (en) | 2009-01-29 | 2010-01-22 | Automatic analyzer |
CN201080005884.XA CN102301243B (zh) | 2009-01-29 | 2010-01-22 | 自动分析装置 |
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US (1) | US8278108B2 (ja) |
JP (2) | JP5452507B2 (ja) |
CN (1) | CN102301243B (ja) |
DE (1) | DE112010000784B4 (ja) |
WO (1) | WO2010087137A1 (ja) |
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WO2013187210A1 (ja) * | 2012-06-11 | 2013-12-19 | 株式会社 日立ハイテクノロジーズ | 自動分析装置 |
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US20160238627A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Decapping and capping apparatus, systems and methods for use in diagnostic analyzers |
CN115128290A (zh) | 2015-03-20 | 2022-09-30 | 株式会社日立高新技术 | 自动分析装置以及自动分析方法 |
CN108027280B (zh) | 2015-06-26 | 2021-07-06 | 雅培实验室 | 用于使得反应容器在诊断分析仪中从处理轨道运动至旋转装置的反应容器运动部件 |
WO2016210420A1 (en) | 2015-06-26 | 2016-12-29 | Abbott Laboratories | Reaction vessel exchanger device for a diagnostic analyzer |
CN108738348B (zh) | 2016-02-17 | 2023-09-01 | 贝克顿·迪金森公司 | 用于相同的诊断测试的自动化样品制备系统 |
CN115754323A (zh) | 2016-04-22 | 2023-03-07 | 贝克顿·迪金森公司 | 自动化诊断分析仪和用于自动化诊断分析仪的操作的方法 |
CN115754322A (zh) | 2016-04-22 | 2023-03-07 | 贝克顿·迪金森公司 | 自动诊断分析仪及其操作方法 |
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- 2010-01-22 CN CN201080005884.XA patent/CN102301243B/zh active Active
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JP5452507B2 (ja) | 2014-03-26 |
US20110283779A1 (en) | 2011-11-24 |
US8278108B2 (en) | 2012-10-02 |
JP2014052391A (ja) | 2014-03-20 |
DE112010000784B4 (de) | 2013-10-31 |
DE112010000784T5 (de) | 2012-07-05 |
CN102301243A (zh) | 2011-12-28 |
JPWO2010087137A1 (ja) | 2012-08-02 |
CN102301243B (zh) | 2013-12-25 |
JP5732521B2 (ja) | 2015-06-10 |
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