WO2010062383A3 - Polypeptides de récepteur stabilisés et leurs utilisations - Google Patents

Polypeptides de récepteur stabilisés et leurs utilisations Download PDF

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Publication number
WO2010062383A3
WO2010062383A3 PCT/US2009/006252 US2009006252W WO2010062383A3 WO 2010062383 A3 WO2010062383 A3 WO 2010062383A3 US 2009006252 W US2009006252 W US 2009006252W WO 2010062383 A3 WO2010062383 A3 WO 2010062383A3
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WO
WIPO (PCT)
Prior art keywords
receptor polypeptides
variants
iib receptor
activin
activin iib
Prior art date
Application number
PCT/US2009/006252
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English (en)
Other versions
WO2010062383A2 (fr
Inventor
Jeonghoon Sun
Lei-Ting Tony Tam
Mark Leo Michaels
Thomas C. Boone
Rohini Deshpande
Yue-Sheng Li
Hq Han
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010062383(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2743850A priority Critical patent/CA2743850C/fr
Priority to KR1020177025044A priority patent/KR20170105124A/ko
Priority to LTEP09761055.4T priority patent/LT2370463T/lt
Priority to CR20160443A priority patent/CR20160443A/es
Priority to SG2011037777A priority patent/SG171813A1/en
Priority to AU2009320364A priority patent/AU2009320364B2/en
Priority to EP16179980.4A priority patent/EP3101029B1/fr
Priority to RS20160909A priority patent/RS55369B1/sr
Priority to JP2011538599A priority patent/JP5611222B2/ja
Priority to CN200980147945.3A priority patent/CN102245634B/zh
Priority to EA201100832A priority patent/EA201100832A1/ru
Priority to ES09761055.4T priority patent/ES2600491T3/es
Priority to UAA201107872A priority patent/UA107921C2/ru
Priority to MX2011005505A priority patent/MX2011005505A/es
Priority to SI200931546A priority patent/SI2370463T1/sl
Application filed by Amgen Inc. filed Critical Amgen Inc.
Priority to KR1020177007651A priority patent/KR101778134B1/ko
Priority to EP09761055.4A priority patent/EP2370463B1/fr
Priority to BRPI0920962A priority patent/BRPI0920962A2/pt
Priority to MA33960A priority patent/MA32936B1/fr
Priority to MEP-2016-243A priority patent/ME02652B/fr
Priority to KR1020117014720A priority patent/KR101720143B1/ko
Priority to DK09761055.4T priority patent/DK2370463T3/en
Publication of WO2010062383A2 publication Critical patent/WO2010062383A2/fr
Publication of WO2010062383A3 publication Critical patent/WO2010062383A3/fr
Priority to IL212773A priority patent/IL212773A/en
Priority to TN2011000238A priority patent/TN2011000238A1/fr
Priority to ZA2011/04648A priority patent/ZA201104648B/en
Priority to HK12103250.5A priority patent/HK1162545A1/zh
Priority to IL248128A priority patent/IL248128A0/en
Priority to HRP20161450TT priority patent/HRP20161450T1/hr
Priority to SM201600417T priority patent/SMT201600417B/it
Priority to CY20161101175T priority patent/CY1118754T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
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Abstract

La présente invention concerne des protéines et des polypeptides stabilisés du récepteur IIB de l'activine pouvant se lier et inhiber les activités de l'activine A, de la myostatine ou de GDF-11. La présente invention concerne également des polynucléotides, des vecteurs et des cellules hôtes pouvant produire des protéines et les polypeptides stabilisés. En outre, elle concerne aussi des compositions et des procédés permettant de traiter des amyotrophies et des troubles métaboliques.
PCT/US2009/006252 2008-11-26 2009-11-24 Polypeptides de récepteur stabilisés et leurs utilisations WO2010062383A2 (fr)

Priority Applications (30)

Application Number Priority Date Filing Date Title
DK09761055.4T DK2370463T3 (en) 2008-11-26 2009-11-24 STABILIZED VARIANT OF activin IIB RECEPTOR
EP09761055.4A EP2370463B1 (fr) 2008-11-26 2009-11-24 Une variant stabilisé d'activin iib récepteur
LTEP09761055.4T LT2370463T (lt) 2008-11-26 2009-11-24 Stabilizuotas aktivino iib receptoriaus variantas
KR1020177007651A KR101778134B1 (ko) 2008-11-26 2009-11-24 액티빈 ｉｉｂ 수용체 폴리펩타이드의 변이체 및 이의 용도
SG2011037777A SG171813A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof
AU2009320364A AU2009320364B2 (en) 2008-11-26 2009-11-24 Variants of activin IIB receptor polypeptides and uses thereof
EP16179980.4A EP3101029B1 (fr) 2008-11-26 2009-11-24 Variants de polypeptides récepteurs iib d'activine et leurs utilisations
KR1020177025044A KR20170105124A (ko) 2008-11-26 2009-11-24 액티빈 ｉｉｂ 수용체 폴리펩타이드의 변이체 및 이의 용도
JP2011538599A JP5611222B2 (ja) 2008-11-26 2009-11-24 アクチビンｉｉｂ受容体ポリペプチドの変異体及びその使用
CN200980147945.3A CN102245634B (zh) 2008-11-26 2009-11-24 激活素iib受体多肽的变异体及其用途
EA201100832A EA201100832A1 (ru) 2008-11-26 2009-11-24 Варианты полипептидов рецептора iib активина и их применение
ES09761055.4T ES2600491T3 (es) 2008-11-26 2009-11-24 Una variante estabilizada de receptor IIB de activina
UAA201107872A UA107921C2 (en) 2008-11-26 2009-11-24 Variants of polypeptide of receptor ivr activin and their use
BRPI0920962A BRPI0920962A2 (pt) 2008-11-26 2009-11-24 variantes de polipeptídeos receptores de activina iib e usos dos mesmos
SI200931546A SI2370463T1 (sl) 2008-11-26 2009-11-24 Stabilizirana varianta IIB receptorja aktivina
CA2743850A CA2743850C (fr) 2008-11-26 2009-11-24 Variantes des polypeptides du recepteur iib de l'activine et leurs utilisations
CR20160443A CR20160443A (es) 2008-11-26 2009-11-24 Variantes de polipéptidos receptores de activina iib y aplicaciones de éstos (divisional)
RS20160909A RS55369B1 (sr) 2008-11-26 2009-11-24 Stabilizovana varijanta aktivin iib receptora
MX2011005505A MX2011005505A (es) 2008-11-26 2009-11-24 Variantes de polipeptidos receptores de activina iib y aplicaciones de estos.
MA33960A MA32936B1 (fr) 2008-11-26 2009-11-24 Polypeptides de recepteur stabilises et leurs utilisations
MEP-2016-243A ME02652B (fr) 2008-11-26 2009-11-24 Une variant stabilisé d'activin iib récepteur
KR1020117014720A KR101720143B1 (ko) 2008-11-26 2009-11-24 액티빈 ｉｉｂ 수용체 폴리펩타이드의 변이체 및 이의 용도
IL212773A IL212773A (en) 2008-11-26 2011-05-08 And variants of activin iib receptor polypeptides and their uses
TN2011000238A TN2011000238A1 (en) 2008-11-26 2011-05-12 Variants of activin iib receptor polypeptides and uses thereof
ZA2011/04648A ZA201104648B (en) 2008-11-26 2011-06-23 Variants of activin iib receptor polypeptides and uses thereof
HK12103250.5A HK1162545A1 (zh) 2008-11-26 2012-04-02 種穩定的活化素 受體變體
IL248128A IL248128A0 (en) 2008-11-26 2016-09-29 Stabilized receptor polypeptides and their use
HRP20161450TT HRP20161450T1 (hr) 2008-11-26 2016-11-03 Stabilizirana varijanta aktivinskog receptora iib
SM201600417T SMT201600417B (it) 2008-11-26 2016-11-16 Una variante stabilizzata di recettore di attivina iib
CY20161101175T CY1118754T1 (el) 2008-11-26 2016-11-16 Μια σταθεροποιημενη παραλλαγη υποδοχεα ακτιβινης ιιb

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US61/200,250 2008-11-26
US25906009P 2009-11-06 2009-11-06
US61/259,060 2009-11-06

Publications (2)

Publication Number Publication Date
WO2010062383A2 WO2010062383A2 (fr) 2010-06-03
WO2010062383A3 true WO2010062383A3 (fr) 2010-08-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/006252 WO2010062383A2 (fr) 2008-11-26 2009-11-24 Polypeptides de récepteur stabilisés et leurs utilisations

Country Status (38)

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US (5) US8410043B2 (fr)
EP (2) EP3101029B1 (fr)
JP (3) JP5611222B2 (fr)
KR (3) KR101720143B1 (fr)
CN (2) CN102245634B (fr)
AR (1) AR074397A1 (fr)
AU (1) AU2009320364B2 (fr)
BR (1) BRPI0920962A2 (fr)
CA (2) CA2997971A1 (fr)
CL (1) CL2011001239A1 (fr)
CO (1) CO6382163A2 (fr)
CR (2) CR20160443A (fr)
CY (1) CY1118754T1 (fr)
DK (1) DK2370463T3 (fr)
EA (2) EA201791940A3 (fr)
ES (1) ES2600491T3 (fr)
HK (1) HK1162545A1 (fr)
HR (1) HRP20161450T1 (fr)
HU (1) HUE032090T2 (fr)
IL (2) IL212773A (fr)
LT (1) LT2370463T (fr)
MA (1) MA32936B1 (fr)
ME (1) ME02652B (fr)
MX (1) MX2011005505A (fr)
MY (1) MY159483A (fr)
NZ (2) NZ627111A (fr)
PE (2) PE20150680A1 (fr)
PL (1) PL2370463T3 (fr)
PT (1) PT2370463T (fr)
RS (1) RS55369B1 (fr)
SG (2) SG10201703067QA (fr)
SI (1) SI2370463T1 (fr)
SM (1) SMT201600417B (fr)
TN (1) TN2011000238A1 (fr)
TW (1) TWI486166B (fr)
UA (1) UA107921C2 (fr)
WO (1) WO2010062383A2 (fr)
ZA (1) ZA201104648B (fr)

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