WO2010048332A3 - Composés de traitement de maladies et troubles ophtalmiques - Google Patents

Composés de traitement de maladies et troubles ophtalmiques Download PDF

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Publication number
WO2010048332A3
WO2010048332A3 PCT/US2009/061545 US2009061545W WO2010048332A3 WO 2010048332 A3 WO2010048332 A3 WO 2010048332A3 US 2009061545 W US2009061545 W US 2009061545W WO 2010048332 A3 WO2010048332 A3 WO 2010048332A3
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WO
WIPO (PCT)
Prior art keywords
compounds
disorders
ophthalmic diseases
treating ophthalmic
treating
Prior art date
Application number
PCT/US2009/061545
Other languages
English (en)
Other versions
WO2010048332A2 (fr
Inventor
Ian L. Scott
Vladimir A. Kuksa
Feng Hong
Ryo Kubota
Jennifer Gage
Original Assignee
Acucela, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41426558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010048332(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2740952A priority Critical patent/CA2740952C/fr
Priority to AU2009308483A priority patent/AU2009308483C1/en
Priority to EP09822658A priority patent/EP2340242A4/fr
Priority to BRPI0919920A priority patent/BRPI0919920A2/pt
Priority to MX2011004315A priority patent/MX2011004315A/es
Application filed by Acucela, Inc. filed Critical Acucela, Inc.
Priority to NZ592993A priority patent/NZ592993A/xx
Priority to JP2011533310A priority patent/JP5773877B2/ja
Priority to CN200980142277.5A priority patent/CN102197023B/zh
Priority to EA201100654A priority patent/EA201100654A1/ru
Publication of WO2010048332A2 publication Critical patent/WO2010048332A2/fr
Publication of WO2010048332A3 publication Critical patent/WO2010048332A3/fr
Priority to IL212404A priority patent/IL212404A0/en
Priority to HK11112714.7A priority patent/HK1158172A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/33—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B59/001—Acyclic or carbocyclic compounds
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/48—N-alkylated amines
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
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    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
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    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
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    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
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Abstract

L'invention porte sur des composés, sur leurs compositions pharmaceutiques et sur des procédés de traitement de maladies et troubles ophtalmiques, telles que la dégénérescence maculaire liée à l'âge et la maladie de Stargardt, à l'aide desdits composés et desdites compositions.
PCT/US2009/061545 2008-10-22 2009-10-21 Composés de traitement de maladies et troubles ophtalmiques WO2010048332A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EA201100654A EA201100654A1 (ru) 2008-10-22 2009-10-21 Соединения для лечения офтальмологических заболеваний и расстройств
JP2011533310A JP5773877B2 (ja) 2008-10-22 2009-10-21 眼の疾患及び障害を治療する化合物
EP09822658A EP2340242A4 (fr) 2008-10-22 2009-10-21 Composés de traitement de maladies et troubles ophtalmiques
BRPI0919920A BRPI0919920A2 (pt) 2008-10-22 2009-10-21 compostos para tratamento de doenças e desordens oftálmicas
MX2011004315A MX2011004315A (es) 2008-10-22 2009-10-21 Compuestos para el tratamiento de enfermedades y transtornos oftalmologicos.
CA2740952A CA2740952C (fr) 2008-10-22 2009-10-21 Composes de traitement de maladies et troubles ophtalmiques
NZ592993A NZ592993A (en) 2008-10-22 2009-10-21 Compounds for treating ophthalmic diseases and disorders
AU2009308483A AU2009308483C1 (en) 2008-10-22 2009-10-21 Compounds for treating ophthalmic diseases and disorders
CN200980142277.5A CN102197023B (zh) 2008-10-22 2009-10-21 治疗眼科疾病和紊乱的化合物
IL212404A IL212404A0 (en) 2008-10-22 2011-04-17 Compounds for treating ophthalmic diseases and disorders
HK11112714.7A HK1158172A1 (en) 2008-10-22 2011-11-23 Compounds for treating ophthalmic diseases and disorders

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US19708108P 2008-10-22 2008-10-22
US19708308P 2008-10-22 2008-10-22
US19709108P 2008-10-22 2008-10-22
US19708208P 2008-10-22 2008-10-22
US61/197,083 2008-10-22
US61/197,091 2008-10-22
US61/197,081 2008-10-22
US61/197,082 2008-10-22

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TW201028370A (en) 2010-08-01
IL212404A0 (en) 2011-06-30
GB2464809A (en) 2010-05-05
NZ592993A (en) 2013-02-22
US20100113539A1 (en) 2010-05-06
CN102197023A (zh) 2011-09-21
MX2011004315A (es) 2011-08-24
WO2010048332A2 (fr) 2010-04-29
KR101546562B1 (ko) 2015-08-25
ECSP11011067A (es) 2011-06-30
CL2011000901A1 (es) 2012-03-16
TWI486326B (zh) 2015-06-01
EP2340242A4 (fr) 2012-04-04
BRPI0919920A2 (pt) 2016-02-16
JP2015145392A (ja) 2015-08-13
US20160145198A1 (en) 2016-05-26
US8674137B2 (en) 2014-03-18
KR20110074778A (ko) 2011-07-01
AU2009308483C1 (en) 2014-01-23
CA2740952A1 (fr) 2010-04-29
EA201100654A1 (ru) 2012-01-30
JP5773877B2 (ja) 2015-09-02
US9193669B2 (en) 2015-11-24
US20140228443A1 (en) 2014-08-14
CA2740952C (fr) 2015-12-29
EP2340242A2 (fr) 2011-07-06
JP2012506449A (ja) 2012-03-15
CN102197023B (zh) 2015-12-16
HK1158172A1 (en) 2012-07-13

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