WO2010047082A1 - Dispositif de mélange de substances et boîtier employé dans celui-ci - Google Patents

Dispositif de mélange de substances et boîtier employé dans celui-ci Download PDF

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Publication number
WO2010047082A1
WO2010047082A1 PCT/JP2009/005468 JP2009005468W WO2010047082A1 WO 2010047082 A1 WO2010047082 A1 WO 2010047082A1 JP 2009005468 W JP2009005468 W JP 2009005468W WO 2010047082 A1 WO2010047082 A1 WO 2010047082A1
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WO
WIPO (PCT)
Prior art keywords
casing
sealed
opening
mixture
substance
Prior art date
Application number
PCT/JP2009/005468
Other languages
English (en)
Japanese (ja)
Inventor
大山義夫
Original Assignee
Oyama Yoshio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oyama Yoshio filed Critical Oyama Yoshio
Publication of WO2010047082A1 publication Critical patent/WO2010047082A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7131—Breaking or perforating packages, containers or vials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7164—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being placed in parallel before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • the present invention relates to a substance mixing apparatus for mixing substances enclosed in an ampule and a casing used for the substance mixing apparatus.
  • a multi-chamber container has been proposed to mix two kinds of liquids.
  • the multi-chamber container has a structure in which the internal space of the resin package is divided into two, for example, and the liquid to be mixed is sealed in each of the two chambers formed by dividing the package into two. . Then, when necessary, the two partitions are separated from each other by damaging the partition that separates the two chambers, or by peeling off the weak seal portion that forms the partition, thereby mixing the two liquids.
  • Patent Document 1 Japanese Patent Laid-Open No. 2008-206686
  • the multi-chamber container as described above is made of resin, the types of liquid that can be sealed are limited. Specifically, it is not possible to enclose liquids that erode the resin and weakly sealed portions in a multi-chamber container for a long period of time.
  • the first object of the present invention is to provide a substance mixing device capable of relaxing restrictions on the types of substances that can be sealed, and a casing used for the substance mixing apparatus.
  • the second object of the present invention is to provide a reusable substance mixing apparatus and a casing used for the substance mixing apparatus.
  • the present invention basically relates to a substance mixing apparatus 10 that obtains a mixture by mixing substances.
  • the substance mixing apparatus 10 of the present invention includes a casing 1 made of a flexible material.
  • the casing 1 has an opening 1a.
  • a plurality of sealed ampules 2 are accommodated in the casing 1.
  • all of the plurality of sealed ampules 2 have breakability.
  • the mixture can be obtained quickly by simply damaging the sealed ampoule 2 in the casing 1. That is, the fluid or substance to be mixed has a long time in the state of being sealed in the sealed ampoule 2. For this reason, there are almost no restrictions on the types of substances that can be sealed in the sealed ampoule 2, and the restrictions on the types can be relaxed as compared with the conventional case. Moreover, it is not necessary for the obtained mixture to contact the casing 1 for a long time. For this reason, even if the casing 1 is made of a material that is easily eroded by the mixture, durability that can withstand at least one use is obtained.
  • the substance mixing apparatus 10 of the present invention it is not necessary to divide the space in the casing 1 into two. That is, it is not necessary to provide a partition wall or a weak seal portion on the casing 1. For this reason, as long as the casing 1 does not deteriorate, it can be reused.
  • the substance mixing apparatus 10 of the present invention includes the recovery container 3, and the filter unit 5 is disposed between the casing 1 and the recovery container 3. This prevents the damaged sealed ampoule 2 from entering the recovery container 3 from the casing 1. Thereby, the possibility that the damaged sealed ampoule 2 is mixed into the target mixture can be eliminated.
  • the closing member 7 is made of an elastic material and can pierce a hollow needle-like object. Using this, while maintaining the airtightness of the space formed by the casing 1 and the recovery container 3, at least a part of the mixture recovered in the recovery container 3 is taken out, or other substances are mixed into the mixture. It becomes possible to do.
  • the mixture collected in the collection container 3 may be stirred using the stirring bar 9.
  • the substance mixing device 10 of the present invention further includes a spray device that can be attached to the collection container 3.
  • This spraying device is attached to the collection container 3 instead of the casing 1.
  • the spray device can spray the mixture collected in the collection container 3. This makes it easier to use the mixture.
  • the casing 1 described above is a member that is long in the longitudinal direction with the opening 1a as one end, and preferably includes a plurality of storage chambers, for example, a first storage chamber and a second storage chamber.
  • the first storage chamber is arranged at one end (opening 1a side) in the longitudinal direction of the casing, and the second storage chamber connected to the first storage chamber is arranged at the other end side in the longitudinal direction.
  • the sealed ampule 2 is accommodated in the first accommodation chamber and the second accommodation chamber. Thereby, the accommodation place of the sealed ampoule 2 can be easily understood. For this reason, the mixing order of substances can be adjusted in the order of selecting the storage chambers.
  • another aspect of the present invention is a casing having a function equivalent to that of the casing 1 used in the substance mixing apparatus 10.
  • a casing suitable for use in the substance mixing apparatus 10 can be provided.
  • the substance mixing apparatus 10 that can relax the restriction on the types of substances that can be sealed. Further, according to the present invention, a reusable substance mixing apparatus 10 can be provided. Furthermore, according to the present invention, a casing 1 suitable for use in the substance mixing apparatus 10 can be provided.
  • FIG. 1 is a front view schematically showing the configuration of the substance mixing apparatus of the present invention.
  • FIG. 2 is a diagram used for explaining an example of another shape of the collection container shown in FIG.
  • FIG. 3 is a diagram used for explaining an example of a state when the substance mixing apparatus of FIG. 1 is used.
  • FIG. 4 is a view showing a substance mixing apparatus according to another embodiment of the present invention.
  • FIG. 1 is a front view schematically showing a configuration of a substance mixing apparatus 10 of the present invention.
  • the substance mixing apparatus 10 of the present invention is for obtaining a fluid mixture by mixing substances sealed in a plurality of sealed ampules 2 (for example, 2a, 2b, 2c described later).
  • a substance mixing apparatus 10 shown in FIG. 1 includes a casing 1.
  • the substance mixing apparatus 10 further includes a collection container 3, a filter unit 5, a closing member 7, and a stirrer 9.
  • the sealed ampoule 2 a damaging one can be used, for example, a glass one.
  • the sealed ampoule 2 is not limited to glass but may be made of a material having brittleness (fragility). Further, in order to enhance the breakability of the sealed ampoule 2, the sealed ampoule 2 is preferably long. Further, in order to enhance the breakability of the sealed ampoule 2, a portion having a partially different thickness may be provided by forming a cut or a groove in the sealed ampoule 2. By doing in this way, even if it is a material (for example, resin material) which is not brittle, it can be used as the constituent material of the sealing ampoule 2.
  • the casing 1 is made of a flexible material, and is made of a resin material such as PP (polypropylene) or PET (polyethylene terephthalate). In this way, the casing 1 can be stretched and deformed by being made of a flexible material. Note that the casing 1 does not need to be entirely made of a flexible material, and at least a portion for accommodating the sealed ampoule 2 only needs to be made of a flexible material. A part of the casing 1 is made of a flexible material, and the remaining part is made of a material having a relatively high rigidity, thereby making it possible to localize an easily deformable place. Bending and twisting are easy.
  • PP polypropylene
  • PET polyethylene terephthalate
  • the casing 1 has a hollow cylindrical bag shape, and the length in the longitudinal direction is, for example, 100 mm. And this casing 1 has the opening part 1a in the end. The opening 1a is used when the sealed ampoule 2 is taken in and out and the mixture is recovered.
  • the casing 1 may have a plurality of storage chambers as will be described later.
  • Examples of the length of the casing 1 are 1 cm or more and 20 cm or less, 2 cm or more and 10 cm or less, or 3 cm or more and 7 cm or less.
  • a portion of the casing 1 that is flexible by the flexible material is a flexible portion that can be bent by the human power.
  • the entire casing 1 is made of a flexible material, it is not necessary for all of the casing 1 to have flexibility. For example, only the side surface of the casing 1 may have flexibility.
  • the collection container 3 is shaped like a bottle whose lower part is wider than the upper part, and a neck part 3 a is provided at the upper part.
  • the material constituting the collection container 3 is, for example, PET (polyethylene terephthalate).
  • PET polyethylene terephthalate
  • the material which comprises the collection container 3 is not restricted to resin materials, such as PET, For example, durable materials, such as glass, may be sufficient.
  • the shape of the collection container 3 is not limited to the bottle shape.
  • the shape of the collection container 3 can be made compact by making the portion excluding the neck portion 3a the same diameter, thereby making it easier to hold.
  • the neck 3a of the collection container 3 has a circular first opening 3b that opens upward.
  • the first opening 3b of the casing 1 can be connected to the neck 3a by extending and covering the vicinity of the opening of the casing 1 with its flexibility. Thereby, the opening 1a of the casing 1 and the first opening 3b of the recovery container 3 are connected to each other. Further, the connecting portion is sealed by the flexibility of the casing 1. That is, the connection portion has a structure in which liquid leakage and liquid or gas entry are unlikely to occur.
  • the filter unit 5 is disposed between the casing 1 and the collection container 3.
  • This filter unit 5 includes at least one filter, and this filter prevents a substance larger than the mesh of the filter from passing through, and passes a substance smaller than the mesh. It is supposed to let you.
  • the filter constituting the filter unit 5 is preferably selected as appropriate according to the fluidity (viscosity) of the target mixture. For example, in the case of a highly viscous mixture, it is preferable to prevent damage to the filter by increasing the thickness of the filter or increasing the rigidity of the filter. Further, a material larger than the mesh may be collected in a relatively low portion by curving the filter and providing a concave portion or a convex portion in the central portion. As a result, clogging of the mesh can be prevented and the portion where the filter is easily damaged can be narrowed.
  • the filter unit 5 includes a filter built-in type perforated rubber stopper 5a and a seal filter 5b as shown in FIG.
  • the perforated rubber stopper 5a is a rubber stopper having a tapered surface, provided with a plurality of through holes along the axial direction of the cylinder, and a filter disposed above the through holes.
  • the stopper need not be made of rubber.
  • the perforated rubber stopper 5a is fitted into the first opening 3b.
  • the seal filter 5b is made of, for example, a fine mesh resin material (for example, TPE (thermoplastic elastomer)). As shown in FIG.
  • a circular second opening 3c is provided on the side surface of the collection container 3 separately from the first opening 3b.
  • the second opening 3c opens upward.
  • the 2nd opening part 3c may be opened toward the side.
  • This 2nd opening part 3c is used when collect
  • the second opening 3c is also used when adjusting the pressure of the space formed by the casing 1 and the recovery container 3 when the casing 1 and the recovery container 3 are connected.
  • an aspirator may be connected to the second opening 3c in order to reduce the pressure in the collection container 3.
  • the closing member 7 is a member for closing the second opening 3c. Thereby, the 2nd opening part 3c is sealed.
  • a rubber plug, a cork plug, a cap (single), a double cap, a stretchable film, or the like can be used as the closing member 7, a rubber plug, a cork plug, a cap (single), a double cap, a stretchable film, or the like.
  • the double cap is a member provided with a partition wall at a substantially central portion on the inner peripheral side of a hollow cylindrical member. One end of the double cap is fitted into the opening, and the other end is deformed so as to be folded back to the one end side, so that the partition wall is exposed to the outside.
  • a cap having a shape complementary to the second opening 3 c is used as the closing member 7.
  • a hollow needle-like object can be inserted into the cap.
  • the hollow needle-like material include a syringe (injector, injector) needle.
  • injector injector
  • the closing member 7 is preferably made of an elastic material.
  • the stirring bar 9 is used by being put in the collection container 3 when stirring the liquid mixture.
  • two spherical bodies are used as the stirring bar 9.
  • the stirrer 9 moves so as to roll on the bottom surface of the recovery container 3 only by moving the recovery container 3.
  • the mixture is also agitated as the stirrer 9 moves.
  • the size of at least one of the first opening 3b and the second opening 3c is determined in consideration of the size of the stirrer 9 and the clearance. Is preferred. More preferably, at least the size of the second opening 3c is determined in consideration of the size of the stirring bar 9 and the clearance.
  • the substance mixing apparatus 10 will be described from a state where it is not assembled as shown in FIG.
  • a sealed ampoule 2 in which a necessary amount of a substance to be mixed is enclosed is prepared for the number of types of substances to be mixed (for example, three).
  • the substances to be mixed is a fluid, and in the example shown in FIG. 1, it is enclosed in a sealed ampoule 2a.
  • the other substance to be mixed is selected from the group consisting of a solid, a liquid that is dispersed or dissolved in the fluid, and a gas that is soluble in the fluid.
  • the sealed ampules 2b and 2c are selected. Is enclosed.
  • the substances to be mixed are most preferably liquids in that a mixture is obtained quickly and does not diffuse toward the outside air.
  • the sealed ampoule 2 can be prepared, for example, by preparing a hollow glass pipe, placing a substance to be sealed in the hollow portion, and closing the open end of the glass pipe with heat or the like. If the material to be sealed is a liquid or a material that is weak against heat, a glass material having one open end may be prepared. When the substance to be sealed is strong against ultraviolet rays, a sealed cell ampule 2 may be prepared by preparing a glass cell and bonding the cell and the cell cap with an ultraviolet curable resin. Further, a commercially available sealed ampoule 2 encapsulating a substance may be prepared.
  • the prepared sealed ampules 2 are put into the casing 1 of the substance mixing apparatus 10 through the openings.
  • the substances to be mixed if there is a substance that does not need to be sealed in the sealed ampoule 2, it may be put directly into the casing 1 or the collection container 3.
  • the collection container 3 provided with the filter part 5 is prepared, and the collection container 3 and the casing 1 are connected.
  • three sealed ampoules 2a, 2b, 2c accommodated in the casing 1 are indicated by hidden lines (broken lines).
  • the stirrer 9 is introduced into the collection container 3, and after the introduction, the second opening 3 c of the collection container 3 is airtightly covered with the closing member 7.
  • the air inside the space formed by the casing 1 and the recovery container 3 may be replaced with a desired gas, or removed using an aspirator or the like. You may care.
  • a desired gas or removed using an aspirator or the like.
  • the gas used for the substitution mention may be made of argon (Ar) and nitrogen (N 2) an inert gas, such as.
  • the gas that is the mixing target may be filled as the gas used for the replacement.
  • the sealed ampoule 2 housed in the casing 1 is broken. Specifically, the sealed ampoule 2 may be grasped by hand indirectly from the outside of the casing 1 and folded.
  • a material having flexibility is used as the material of the casing 1, not only can the sealed ampoule 2 be easily broken, but there is no risk of injury even if it is grasped by hand.
  • the sealed ampoule 2 may be damaged by remote control.
  • remote operation external pressure is applied to the casing 1 so that the casing 1 bends or the casing 1 is twisted, or the pressure inside the casing 1 is lowered, or from the outside.
  • vibration (ultrasonic wave) or the like may be applied to the sealed ampoule 2.
  • the present invention is effective in that the mixture can be obtained in a place where a person such as a clean room cannot enter.
  • substances that are harmful to the human body can be prepared without human attendance.
  • the substance enclosed in the sealed ampoule 2 diffuses into the casing 1 and becomes a mixture.
  • the mixing order may become a problem.
  • the casing 1 is preferably made of a transparent material, whereby the plurality of sealed ampoules 2 can be distinguished from the outside of the casing 1.
  • the casing 1 includes at least a first storage chamber disposed at one end in the longitudinal direction and connected to the opening 1a, and a second storage chamber connected to the first storage chamber.
  • the chamber contains a sealed ampule 2b in which a solid substance is enclosed
  • the second accommodation chamber contains a sealed ampule 2a in which a liquid is enclosed.
  • the sealed ampoule 2b located in the lower part in the vertical direction is first broken, and then the sealed ampoule 2a is broken, so that the solid substance can flow down while being dissolved in the liquid. That is, it becomes difficult for the solid substance to remain in the casing 1.
  • the sealed ampoule 2 at the upper side in the vertical direction may be broken before the sealed ampoule 2 at the lower side.
  • the storage chambers may be provided on the other end side in the longitudinal direction of the casing 1 so as to be connected to the second storage chamber.
  • the mixture moves from the casing 1 through the filter unit 5 to the collection container 3 below.
  • the filter unit 5 prevents the fragments of the sealed ampules 2a, 2b, 2c from entering the collection container 3.
  • only the mixture can be recovered.
  • the casing 1 having flexibility can be crushed and moved to the collection container 3 side.
  • FIG. 3 shows a state when the needle of the syringe is inserted into the closing member 7.
  • a syringe needle can be inserted into the closure member 7 and a portion of the mixture can be removed for analysis, for example. Since an elastic material is used as the closing member 7, even if the needle of the syringe is removed, the airtightness can be made difficult to be impaired.
  • the closing member 7 may be removed from the second opening 3c and an aspirator may be connected to the second opening 3c. Thereby, the recovery rate of the mixture remaining in the casing 1 can be increased.
  • the substance mixing apparatus 10 is disassembled. Specifically, the closing member 7 is removed from the second opening 3 c, the casing 1 is removed from the collection container 3, and the filter unit 5 is removed from the collection container 3. Further, the stirring bar 9 is also taken out from the collection container 3. Thereby, only the collection container 3 can be separated from the substance mixing apparatus 10. For this reason, it becomes easy to transfer the obtained mixture from the collection container 3 to another container.
  • the collection container 3 containing the mixture may be attached to a spray pump or the like as a spray device to spray the mixture. This makes it easy to use the mixture. Since the spraying device is attached to the recovery container 3 instead of the casing 1, it is preferable that the spraying device can be attached to the neck portion 3 a of the recovery container 3. In this case, the collection container 3 preferably has a compact shape as shown in FIG. 2 in order to facilitate carrying with the spray device attached.
  • the substance mixing apparatus 10 can quickly obtain a mixture simply by damaging the sealed ampoule 2 in the casing 1. That is, the substance to be mixed has a long time in the state of being sealed in the sealed ampoule 2. For this reason, there are almost no restrictions on the types of substances that can be sealed in the sealed ampoule 2, and the restrictions on the types can be relaxed as compared with the conventional case. Moreover, it is not necessary for the obtained mixture to contact the casing 1 for a long time. For this reason, even if the casing 1 is made of a material that is easily eroded by the mixture, durability that can withstand at least one use is obtained.
  • the substance to be mixed can be sealed in the sealed ampoule 2 until just before the mixture is obtained. For this reason, it is very effective in that a substance that easily deteriorates (for example, pharmaceuticals, nutrients, and cosmetic effect ingredients) can be stored without deterioration until immediately before use (for example, injection, drinking, application). is there. Furthermore, according to the present invention, the mixture can be obtained quickly, so that it is possible to reduce the time and effort required for the stabilization process when synthesizing other substances by mixing. It is possible to eliminate the addition of antioxidants and preservatives to the mixture, and to simplify the storage container for substances.
  • a substance that easily deteriorates for example, pharmaceuticals, nutrients, and cosmetic effect ingredients
  • the space in the casing 1 may be divided into a plurality of storage chambers. However, in this case, each accommodation room is connected to other accommodation rooms. That is, also in this case, it is not necessary to provide a partition wall or a weak seal portion in the casing 1.
  • the substance mixing device 10 is provided with the filter unit 5 between the casing 1 and the recovery container 3, so that the fragments of the sealed ampoule 2 enter the recovery container 3 from the casing 1. Is prevented. Thereby, the possibility that the fragments of the sealed ampoule 2 are mixed into the target mixture can be eliminated.
  • the gas may be removed as the target mixture. preferable.
  • the second opening 3 c provided in the collection container 3 is closed by the closing member 7.
  • the closing member 7 is made of an elastic material and can pierce a hollow needle-like object. Using this, while maintaining the airtightness of the space formed by the casing 1 and the recovery container 3, at least a part of the mixture recovered in the recovery container 3 is taken out, or other substances are mixed into the mixture. It becomes possible to do.
  • the substance enclosed in the sealed ampule 2 can be mixed by using the casing 1 and damaging the sealed ampule 2 in the casing 1. Therefore, only the casing 1 constitutes the present invention. Furthermore, the mixture in the casing 1 can be easily recovered by removing the damaged sealed ampoule 2 by filtering. Moreover, in the substance mixing apparatus 10 mentioned above, you may comprise only the casing 1 by replacing
  • the one in which the collection container 3 and the casing 1 are connected can be regarded as one large casing. That is, the portion of the large casing made of the flexible material corresponds to the casing 1, and the portion made of a relatively high rigidity material corresponds to the collection container 3. In this case, it is also possible to mix the substances by arranging the substances in the collection container 3 in advance and dropping the liquid from the casing 1 into the collection container 3. In other words, the large casing also functions as a dropping device.
  • FIG. 4 is a diagram showing a substance mixing apparatus related to an embodiment different from the above of the present invention.
  • This substance mixing apparatus 10 is of a type that can be equipped with a nebulizer 11 in addition to the configuration shown in FIG. Not only this embodiment but the 2nd opening part 3c may be provided in the upper surface of the collection container 3, and may be provided in a side surface.
  • the collection container 3 can be connected to the opening 1 a of the casing 1. And it has the filter part 5 arrange
  • the collection container 3 has a first opening 3b to which the opening 1a of the casing 1 is connected and a second opening 3c to which the sprayer 11 is attached.
  • the second opening 3c and the first opening 3b are openings provided at different positions.
  • the casing 1 may further include one or a plurality of sealed ampules in addition to the first sealed ampule 2a and the second sealed ampule 2b or 2c.
  • the mixture recovered in the recovery container 3 is sprayed through the sprayer 11.
  • the sprayer 11 is attached to the second opening 3c.
  • a nozzle that can discharge liquid instead of the sprayer 11 may be attached. In either case, the liquid mixture recovered in the recovery container 3 can be easily taken out of the container.
  • the stirrer 9 is an optional element, and the substance mixing apparatus 10 may not have the stirrer 9 when it is not necessary to expand the sales of the mixed liquid.
  • a preferred embodiment of the present invention has a check valve between the collection container 3 and the discharge port for discharging the mixed liquid to the outside. Since the substance mixing apparatus 10 of this aspect can prevent the situation where air enters into the collection container 3 from the discharge port, the situation where the mixed liquid is oxidized can be effectively prevented.
  • the substance mixing device 10 and the casing 1 of the present invention can be suitably used in the field of mixing a plurality of substances.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Package Specialized In Special Use (AREA)

Abstract

L’invention concerne un dispositif de mélange de substances, qui rend possible de réduire les restrictions relatives aux types de substances pouvant être chargées dans celui-ci, ainsi qu’un boîtier employé dans celui-ci. L’invention concerne ainsi un dispositif de mélange de substances (10), qui comprend un boîtier (1) ayant une partie d’ouverture (1a). Le boîtier (1) loge une ampoule scellée (2a) et des ampoules scellées (2b, 2c), et leurs sections de logement sont fabriquées en un matériau flexible. Un fluide est chargé dans l’ampoule scellée (2a) et une substance est chargée dans les ampoules scellées (2b, 2c). En outre, l’ampoule scellée (2a) et les ampoules scellées (2b, 2c) étant logées dans le boîtier (1), l’ampoule scellée (2a) et les ampoules scellées (2b, 2c) sont brisées. En conséquence, le fluide et la substance sont mélangés.
PCT/JP2009/005468 2008-10-22 2009-10-19 Dispositif de mélange de substances et boîtier employé dans celui-ci WO2010047082A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008271473 2008-10-22
JP2008-271473 2008-10-22

Publications (1)

Publication Number Publication Date
WO2010047082A1 true WO2010047082A1 (fr) 2010-04-29

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ID=42119137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/005468 WO2010047082A1 (fr) 2008-10-22 2009-10-19 Dispositif de mélange de substances et boîtier employé dans celui-ci

Country Status (1)

Country Link
WO (1) WO2010047082A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113242768A (zh) * 2018-12-21 2021-08-10 水景有限公司 盒
CN115158889A (zh) * 2022-09-05 2022-10-11 常州远望流体科技有限公司 包装瓶

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62207468A (ja) * 1986-02-26 1987-09-11 ヘキスト・アクチエンゲゼルシヤフト 薬剤懸濁液投与用装置
JPH0510257U (ja) * 1991-07-17 1993-02-09 株式会社大阪製薬 薬剤供給蓋
JP2005530656A (ja) * 2002-06-25 2005-10-13 アメリカ合衆国 混合バイアル
JP2005289518A (ja) * 1995-06-07 2005-10-20 Sprayex Llc 再装填可能なディスペンサー
JP2006001610A (ja) * 2004-06-18 2006-01-05 Sumitomo Chemical Co Ltd 農薬容器
JP2006055549A (ja) * 2004-08-24 2006-03-02 Otsuka Pharmaceut Factory Inc 医療用複室容器
WO2006127098A2 (fr) * 2005-05-24 2006-11-30 Texaco Development Corporation Procede et trousse d'essai pour la determination de teneur en fer dans des lubrifiants en service
WO2007077941A1 (fr) * 2006-01-06 2007-07-12 Lumica Co., Ltd. Procede de detection de detergent residuel et dipositif de detection correspondant
JP2007210683A (ja) * 2007-02-06 2007-08-23 Masahiro Ishida クリーム包装体

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62207468A (ja) * 1986-02-26 1987-09-11 ヘキスト・アクチエンゲゼルシヤフト 薬剤懸濁液投与用装置
JPH0510257U (ja) * 1991-07-17 1993-02-09 株式会社大阪製薬 薬剤供給蓋
JP2005289518A (ja) * 1995-06-07 2005-10-20 Sprayex Llc 再装填可能なディスペンサー
JP2005530656A (ja) * 2002-06-25 2005-10-13 アメリカ合衆国 混合バイアル
JP2006001610A (ja) * 2004-06-18 2006-01-05 Sumitomo Chemical Co Ltd 農薬容器
JP2006055549A (ja) * 2004-08-24 2006-03-02 Otsuka Pharmaceut Factory Inc 医療用複室容器
WO2006127098A2 (fr) * 2005-05-24 2006-11-30 Texaco Development Corporation Procede et trousse d'essai pour la determination de teneur en fer dans des lubrifiants en service
WO2007077941A1 (fr) * 2006-01-06 2007-07-12 Lumica Co., Ltd. Procede de detection de detergent residuel et dipositif de detection correspondant
JP2007210683A (ja) * 2007-02-06 2007-08-23 Masahiro Ishida クリーム包装体

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113242768A (zh) * 2018-12-21 2021-08-10 水景有限公司 盒
CN115158889A (zh) * 2022-09-05 2022-10-11 常州远望流体科技有限公司 包装瓶
CN115158889B (zh) * 2022-09-05 2022-11-29 常州远望流体科技有限公司 包装瓶

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