WO2010039006A2 - 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체 - Google Patents

송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체 Download PDF

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Publication number
WO2010039006A2
WO2010039006A2 PCT/KR2009/005653 KR2009005653W WO2010039006A2 WO 2010039006 A2 WO2010039006 A2 WO 2010039006A2 KR 2009005653 W KR2009005653 W KR 2009005653W WO 2010039006 A2 WO2010039006 A2 WO 2010039006A2
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WO
WIPO (PCT)
Prior art keywords
solid microstructure
microstructure
viscous composition
solid
same
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PCT/KR2009/005653
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English (en)
French (fr)
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WO2010039006A3 (ko
Inventor
정형일
김정동
이광
Original Assignee
연세대학교 산학협력단
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Application filed by 연세대학교 산학협력단 filed Critical 연세대학교 산학협력단
Priority to US13/122,401 priority Critical patent/US20110177297A1/en
Priority to CN2009801483529A priority patent/CN102238938A/zh
Priority to JP2011530002A priority patent/JP2012504034A/ja
Publication of WO2010039006A2 publication Critical patent/WO2010039006A2/ko
Publication of WO2010039006A3 publication Critical patent/WO2010039006A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y10T428/24612—Composite web or sheet

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Moulding By Coating Moulds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

본 발명은 (a) 기판 상에 점성조성물을 준비하는 단계; (b) 리프팅 지지체 (lifting support)의 접촉돌기를 상기 점성조성물에 접촉시키는 단계; (c) 상기 점성조성물에 송풍하여 점성조성물을 응축(condensation) 및 응고(solidiification)시키는 단계; 및 (d) 상기 단계 (c)의 결과물을 절단하여 마이크로구조체를 형성시키는 단계를 포함하는 솔리드 마이크로구조체의 제조방법, 그리고 이에 의해 제조된 솔리드 마이크로구조체에 관한 것이다. 본 발명에 따르면, 마이크로 단위의 직경, 충분한 유효 길이 및 경도를 가지면서 열에 민감한 약물들을 변성 또는 비활성 없이 용이하게 내포할 수 있는 솔리드 마이크로구조체를 제조할 수 있으며 간단하고 신속하면서도 보다 저가의 생산비용으로 원하는 특성 (예컨대, 유효길이, 상단부 직경 및 경도)을 갖는 솔리드 마이크로구조체를 제조할 수 있다.
PCT/KR2009/005653 2008-10-02 2009-10-01 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체 WO2010039006A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/122,401 US20110177297A1 (en) 2008-10-02 2009-10-01 Method of manufacturing solid microstructure and solid microstructure manufactured based on same
CN2009801483529A CN102238938A (zh) 2008-10-02 2009-10-01 制备固体微结构的方法和基于该方法制备的固体微结构
JP2011530002A JP2012504034A (ja) 2008-10-02 2009-10-01 送風によるソリッドマイクロ構造体の製造方法及びこれから製造されたソリッドマイクロ構造体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0097111 2008-10-02
KR20080097111 2008-10-02

Publications (2)

Publication Number Publication Date
WO2010039006A2 true WO2010039006A2 (ko) 2010-04-08
WO2010039006A3 WO2010039006A3 (ko) 2010-07-22

Family

ID=42074033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005653 WO2010039006A2 (ko) 2008-10-02 2009-10-01 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체

Country Status (5)

Country Link
US (1) US20110177297A1 (ko)
JP (1) JP2012504034A (ko)
KR (1) KR101136738B1 (ko)
CN (1) CN102238938A (ko)
WO (1) WO2010039006A2 (ko)

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JP2010234567A (ja) * 2009-03-30 2010-10-21 Toppan Printing Co Ltd 針状体製造方法および針状体
JP2013094662A (ja) * 2012-05-02 2013-05-20 Kosumedei Seiyaku Kk マイクロニードル溶着法
JP2014505511A (ja) * 2010-12-17 2014-03-06 ラファス カンパニー リミテッド マイクロ構造体の製造方法
US20180056053A1 (en) * 2016-08-26 2018-03-01 Juvic Inc. Protruding microstructure for transdermal delivery
US11065428B2 (en) 2017-02-17 2021-07-20 Allergan, Inc. Microneedle array with active ingredient
EP3973975A4 (en) * 2019-05-20 2023-06-21 CJ Cheiljedang Corporation ANTI-INFLUENCE VIRUS COMPOSITION, RESPIRATORY DISEASE TREATMENT COMPOSITION AND ANTI-AGING COMPOSITION WITH DARK GINSENG EXTRACT

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US8545741B2 (en) 2010-04-01 2013-10-01 Nurim Wellness Co. Ltd. Method of manufacturing microstructure
WO2012095746A2 (en) 2011-01-11 2012-07-19 Capsugel Belgium Nv New hard capsules
KR101314091B1 (ko) * 2011-07-26 2013-10-04 연세대학교 산학협력단 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법
CN102755691A (zh) * 2012-06-19 2012-10-31 吉林大学 高灵敏医用微针阵列电极
WO2014129816A1 (ko) * 2013-02-22 2014-08-28 연세대학교 산학협력단 음압을 이용한 마이크로구조체의 제조방법 및 그로부터 제조된 마이크로구조체
KR101821572B1 (ko) 2013-06-17 2018-01-26 주식회사 주빅 무고통 및 무패치의 슈팅 마이크로구조체
WO2015073919A1 (en) * 2013-11-14 2015-05-21 University Medical Pharmaceuticals Corporation Microneedles for therapeutic agent delivery with improved mechanical properties
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KR101828591B1 (ko) * 2014-05-22 2018-02-14 주식회사 주빅 Ccdp 방법에 의한 마이크로구조체의 제조
KR101754309B1 (ko) * 2014-08-21 2017-07-07 주식회사 주빅 음압을 이용한 마이크로구조체의 제조방법 및 그로부터 제조된 마이크로구조체
JP6622818B2 (ja) 2014-12-16 2019-12-18 チュビック インコーポレイテッドＪｕｖｉｃ Ｉｎｃ． 微細ルームマイクロ構造体及びその製造方法
WO2017065570A1 (ko) * 2015-10-14 2017-04-20 주식회사 주빅 겔형 고분자 물질을 이용한 마이크로구조체 및 이의 제조방법
KR101719319B1 (ko) * 2016-04-05 2017-03-23 주식회사 엘지생활건강 효율적인 피부 천공을 위한 마이크로니들 구조
KR101698846B1 (ko) 2016-06-23 2017-01-23 이상혁 마이크로 니들 제조 방법 및 장치, 마이크로 니들, 및 컴퓨터 판독가능 기록 매체
KR101697556B1 (ko) * 2016-08-05 2017-01-18 이상혁 마이크로 구조체 제조장치, 제조방법 및 이로부터 제조된 마이크로 구조체
CN107184417B (zh) * 2017-03-31 2020-04-28 广州新济药业科技有限公司 可溶性微针贴片及其制备方法
CN110678170A (zh) 2017-04-14 2020-01-10 比利时胶囊公司 普鲁兰多糖胶囊
BR112019021396A2 (pt) 2017-04-14 2020-04-28 Capsugel Belgium Nv processo para fabricação de pululano
CN109420245A (zh) * 2017-08-30 2019-03-05 优微（珠海）生物科技有限公司 可溶性微针的制造方法
KR102138060B1 (ko) * 2018-08-13 2020-07-28 한국원자력연구원 마이크로니들형 하이드로겔 제조용 조성물 및 마이크로니들형 하이드로겔의 제조방법
KR102039582B1 (ko) * 2018-12-12 2019-11-01 주식회사 라파스 인장 공정으로 제조하기에 적합한 마이크로니들 재료의 적합성 시험 방법 및 이를 포함하는 마이크로니들 제조 방법
KR102103194B1 (ko) * 2019-01-07 2020-04-22 주식회사 라파스 생체 친화성 마이크로구조체를 이용한 마이크로구조체 형상 마스터 몰드의 제조방법
KR20200098894A (ko) 2019-02-13 2020-08-21 (주)현진자동화 마이크로 니들 제조 장치 및 제조 방법
KR102345734B1 (ko) 2019-06-21 2021-12-31 주식회사 라파스 최소 침습적 바이오 센싱을 위한 생체적합성이고 전기전도성인 고분자 마이크로니들 바이오 센서
TW202138021A (zh) * 2019-12-03 2021-10-16 美商傳斯德姆公司 微結構製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010234567A (ja) * 2009-03-30 2010-10-21 Toppan Printing Co Ltd 針状体製造方法および針状体
JP2014505511A (ja) * 2010-12-17 2014-03-06 ラファス カンパニー リミテッド マイクロ構造体の製造方法
CN105854172A (zh) * 2010-12-17 2016-08-17 株式会社乐派司 微结构体的制造方法
JP2013094662A (ja) * 2012-05-02 2013-05-20 Kosumedei Seiyaku Kk マイクロニードル溶着法
US20180056053A1 (en) * 2016-08-26 2018-03-01 Juvic Inc. Protruding microstructure for transdermal delivery
US11065428B2 (en) 2017-02-17 2021-07-20 Allergan, Inc. Microneedle array with active ingredient
EP3973975A4 (en) * 2019-05-20 2023-06-21 CJ Cheiljedang Corporation ANTI-INFLUENCE VIRUS COMPOSITION, RESPIRATORY DISEASE TREATMENT COMPOSITION AND ANTI-AGING COMPOSITION WITH DARK GINSENG EXTRACT

Also Published As

Publication number Publication date
CN102238938A (zh) 2011-11-09
KR20100038071A (ko) 2010-04-12
US20110177297A1 (en) 2011-07-21
WO2010039006A3 (ko) 2010-07-22
JP2012504034A (ja) 2012-02-16
KR101136738B1 (ko) 2012-04-19

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